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- Doerge, D.R., et al. Show all 4 Authors
- Journal of agricultural and food chemistry 2004 v.52 no.13 pp. 4344-4349
- feed meals; DNA adducts; chemical reactions; acrylamides; animal experimentation; laboratory animals; mice; mass spectrometry; feed contamination; animal models; liquid chromatography; genotoxicity; toxicity testing; autoclaves; autoclaving
- ... Acrylamide (AA) is a neurotoxic and carcinogenic contaminant that is formed during the cooking of starchy foods. Assessment of human risks from toxicants is routinely performed using laboratory rodents, and such testing requires careful control of unintended exposures, particularly through the diet. This study describes an analytical method based on liquid chromatography with electrospray tandem m ...
- Doerge, D.R., et al. Show all 6 Authors
- Journal of agricultural and food chemistry 2004 v.52 no.21 pp. 6623-6632
- metabolism; humans; medicinal properties; formononetin; cytochrome P-450; Trifolium pratense; genistein; daidzein; liver microsomes; enzyme inhibition
- ... Biochanin A and formononetin are the predominant isoflavones in red clover. In a previous study (J. Agric. Food Chem. 2002, 50, 4783-4790), it was demonstrated that human liver microsomes converted biochanin A and formononetin to genistein and daidzein. This paper now shows CYP1B1-catalyzed O-demethylation of biochanin A and formononetin to produce genistein and daidzein, respectively, which inhib ...