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- Eckstein-Ludwig, U.; Webb, R.J.; Van Goethem, I.D.A.; East, J.M.; Lee, A.G.; Kimura, M.; O'Neill, P.M.; Bray, P.G.; Ward, S.A.; Krishna, S.
- Nature 2003 v.424 no.6951 pp. 957-961
- quinine, etc ; Plasmodium falciparum; Ca2-transporting ATPase; enzyme activity; enzyme inhibitors; enzyme inhibition; artemisinin; chloroquine; medicinal properties; Show all 9 Subjects
- ... Artemisinins are extracted from sweet wormwood (Artemisia annua) and are the most potent antimalarials available, rapidly killing all asexual stages of Plasmodium falciparum. Artemisinins are sesquiterpene lactones widely used to treat multidrug-resistant malaria, a disease that annually claims 1 million lives. Despite extensive clinical and laboratory experience their molecular target is not yet ...
- Andrade-Neto, V.F.; Brandão, M.G.L.; Stehmann, J.R.; Oliveira, L.A.; Krettli, A.U.
- Journal of ethnopharmacology 2003 v.87 no.2-3 pp. 253-256
- quinine, etc ; Cinchona calisaya; Cinchona pubescens; Plasmodium berghei; Strychnos; bark; ethanol; fever; leaves; malaria; mice; mortality; plant extracts; roots; Brazil; Show all 15 Subjects
- ... For centuries, malaria was treated with the bark of Cinchona calisaya and Cinchona succirubra plants named “quinas” in Brazil, from which the quinine molecule was isolated. Other plant species known also as “quinas” are used to treat fever and malaria, like Deianira erubescens (roots and leaves), Strychnos pseudoquina (bark), and Remijia ferruginea (bark). Based on this popular knowledge, we evalu ...