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- Zhou, Y.T.; Grayburn, P.; Karim, A.; Shimabukuro, M.; Higa, M.; Baetens, D.; Orci, L.; Unger, R.H.
- Proceedings of the National Academy of Sciences of the United States of America 2000 v.97 no.4 pp. 1784-1789
- rats, etc ; obesity; myocardium; triacylglycerols; sphingolipids; apoptosis; heart diseases; oxygenases; transcription factors; messenger RNA; enzymes; fatty acids; oxidation; electrocardiography; cytoplasmic inclusions; drugs; nitric oxide synthase; Show all 17 Subjects
- ... To determine the mechanism of the cardiac dilatation and reduced contractility of obese Zucker Diabetic Fatty rats, myocardial triacylglycerol (TG) was assayed chemically and morphologically. TG was high because of underexpression of fatty acid oxidative enzymes and their transcription factor, peroxisome proliferator-activated receptor-alpha. Levels of ceramide, a mediator of apoptosis, were 2-3 t ...
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- Horst, R.; Prapong, S.; Reinhardt, T.; Koszewski, N.; Knutson, J.; Bishop, C.
- Biochemical pharmacology 2000 v.60 no.5 pp. 701
- rats, etc ; calcitriol; vitamin D; Ca2-transporting ATPase; cytochrome P-450; messenger RNA; gene expression regulation; receptors; animal models; blood plasma; urine; calcium; duodenum; plasma membrane; hypercalcemia; vitamin metabolism; protein binding; human health; Show all 18 Subjects
- ... The present experiments were conducted to compare the relative hypercalciuric and hypercalcemic activities of 1,24-dihydroxyvitamin D2 [1,24-(OH)2D2], 1,24-dihydroxyvitamin D3 [1,24-(OH)2D3], and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] in 7-week-old rats. The rats were dosed orally with each sterol for 7 days at a rate of 1 ng/g body weight/day. We also monitored the effect of the three compounds ...
- Bole-Feysot, Christine; Perret, Eric; Roustan, Paul; Bouchard, Brigitte; Kelly, Paul A
- Genome biology 2000 v.1 no.4 pp. 62
- rats, etc ; Northern blotting; cell growth; complementary DNA; gene expression; gene expression regulation; genes; messenger RNA; mitogenesis; models; neoplasm cells; prolactin; proteins; screening; signal transduction; suppression subtractive hybridization; transcription (genetics); Show all 17 Subjects
- ... BACKGROUND: Rat Nb2-11C lymphoma cells are dependent on prolactin for proliferation and are widely used to study prolactin signaling pathways. To investigate the role of this hormone in the transcriptional mechanisms that underlie prolactin-stimulated mitogenesis, five different techniques were used to isolate differentially expressed transcripts: mRNA differential display, representational differ ...
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