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- Ashrafi, K.; Sinclair, D.; Gordon, J.I.; Guarente, L.
- Proceedings of the National Academy of Sciences of the United States of America 1999 v.96 no.16 pp. 9100-9105
- longevity, etc ; Saccharomyces cerevisiae; developmental stages; nutrient deficiencies; starvation; cell cycle; ribosomal DNA; DNA conformation; cells; cell nucleolus; Show all 10 Subjects
- ... Saccharomyces cerevisiae mother cells undergo an aging program that includes morphologic changes, sterility, redistribution of the Sir transcriptional silencing complex from HM loci and telomeres to the nucleolus, alterations in nucleolar architecture, and accumulation of extrachromosomal ribosomal DNA circles (ERCs). We report here that cells starved for nutrients during prolonged periods in stat ...
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