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1. K562 cell-derived exosomes suppress the adhesive function of bone marrow mesenchymal stem cells via delivery of miR-711

Author:
Yu-Huan Jiang; Jing Liu; Jin Lin; Shu-Qi Li; Yan-Mei Xu; Qing-Hua Min; Qiong-Hui Zhong; Fan Sun; Jing Li; Xia-Hong You; Kai-Li Liao; Ting-Yu Qin; Cui Zhao; Bo Huang; Xiao-Zhong Wang
Source:
Biochemical and biophysical research communications 2020 v.521 no.3 pp. 584-589
ISSN:
0006-291X
Subject:
adhesion; bone marrow; coculture; exosomes; leukemia; microRNA; research
Abstract:
... A failure of bone marrow mesenchymal stem cells (BM-MSCs) to adhere to hematopoietic cells is an essential cause of the progression of chronic myelogenous leukemia and is also a cause of failure of bone marrow (BM) transplantation, but the exact mechanisms of this have not been fully elucidated. Recent studies have indicated that microRNAs (miRNAs) are contained in leukemia-derived exosomes and ar ...
DOI:
10.1016/j.bbrc.2019.10.096