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You searched for: Publication Year 2019 Remove constraint Publication Year: 2019 Subject Danio rerio Remove constraint Subject: Danio rerio
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1. 1,3‐1‐6 ß‐glucans enhance tissue regeneration in zebrafish (Danio rerio): Potential advantages for aquaculture applications

Author:
Baldassare Fronte; Cheol‐Hee Kim; Marco Bagliacca; Lucia Casini; Mahanama De Zoysa
Source:
Aquaculture research 2019 v.50 no.11 pp. 3163-3170
ISSN:
1355-557X
Subject:
Danio rerio; amputation; animal models; aquaculture; beta-glucans; diet; fish; gills; macrophages; oral administration; secondary infection; stocking rate; tissue repair; tissues
Abstract:
... High aquacultural rearing density and handling of fish may frequently result in skin or gills wounds, thereby facilitating the onset of secondary infections. The capacity of the zebrafish to regenerate tissues, as well as fins and other organs, makes it an ideal animal model for studying the mechanisms of tissue regeneration. Since macrophages are involved in tissue regeneration, a diet including ...
DOI:
10.1111/are.14270

2. 2,4-Dichlorophenoxyacetic acid containing herbicide impairs essential visually guided behaviors of larval fish

Author:
Gavin K. Dehnert; William H. Karasov; Marc A. Wolman
Source:
Aquatic toxicology 2019 v.209 pp. 1-12
ISSN:
0166-445X
Subject:
2,4-D; Danio rerio; Perca flavescens; active ingredients; auxins; cell death; ecosystems; fish communities; fish larvae; freshwater fish; invasive species; nervous system; neural networks; nontarget organisms; plants (botany); spawning; toxicity; vision; xenobiotics
Abstract:
... Aquatic herbicides are used worldwide to eradicate nuisance and invasive plants despite limited knowledge of their toxicity to non-target organisms. 2,4-Dichlorophenoxyacetic acid (2,4-D) is a common active ingredient in commercial herbicide formulations, which triggers plant cell death by mimicking the plant-specific hormone auxin. Application practices of 2,4-D commercial herbicides typically co ...
DOI:
10.1016/j.aquatox.2019.01.015

3. Caenorhabditis elegans Infrared-Based Motility Assay Identified New Hits for Nematicide Drug Development

Author:
Gastón Risi; Elena Aguilera; Enrique Ladós; Gonzalo Suárez; Inés Carrera; Guzmán Álvarez; Gustavo Salinas
Source:
Veterinary sciences 2019 v.6 no.1 pp. -
ISSN:
2306-7381
Subject:
Caenorhabditis elegans; Danio rerio; Haemonchus contortus; active ingredients; animal models; aromatic compounds; automation; drug development; drugs; free-living nematodes; hydrazine; ketones; livestock; nematicides; parasites; screening; vertebrates
Abstract:
... Nematode parasites have a profound impact on humankind, infecting nearly one-quarter of the world’s population, as well as livestock. There is a pressing need for discovering nematicides due to the spread of resistance to currently used drugs. The free-living nematode Caenorhabditis elegans is a formidable experimentally tractable model organism that offers key advantages in accelerating nem ...
DOI:
10.3390/vetsci6010029
PubMed:
30884899
PubMed Central:
PMC6466232

4. Accumulation of different shapes of microplastics initiates intestinal injury and gut microbiota dysbiosis in the gut of zebrafish

Author:
Ruxia Qiao; Yongfeng Deng; Shenghu Zhang; Marina Borri Wolosker; Qiande Zhu; Hongqiang Ren; Yan Zhang
Source:
Chemosphere 2019 v.236 pp. 124334
ISSN:
0045-6535
Subject:
Danio rerio; bacteria; bioaccumulation; dysbiosis; fish; health effects assessments; inflammation; intestinal microorganisms; intestines; metabolism; microplastics; permeability; toxicity
Abstract:
... Different shapes of microplastics are widely detected in the environment and organisms and most of them remain in the gut. However, the influences of shapes on the bioaccumulation and toxicity of microplastics in the gut are largely unknown. Three shapes (bead, fragment, and fiber) of microplastics of comparable size in one dimension were prepared to exposure to zebrafish. The accumulation and tox ...
DOI:
10.1016/j.chemosphere.2019.07.065

5. Acetaminophen Removal from Water by Microalgae and Effluent Toxicity Assessment by the Zebrafish Embryo Bioassay

Author:
Carla Escapa; Ricardo N. Coimbra; Teresa Neuparth; Tiago Torres; Miguel M. Santos; Marta Otero
Source:
Water 2019 v.11 no.9 pp. -
ISSN:
2073-4441
Subject:
Chlorella sorokiniana; Chlorella vulgaris; Danio rerio; Scenedesmus obliquus; acetaminophen; bioassays; biodegradation; effluents; embryo (animal); microalgae; toxicity; water treatment
Abstract:
... In this work, zebrafish embryo bioassays were performed to assess the efficiency of microalgae in the removal of acetaminophen from water. Chlorella sorokiniana (CS), Chlorella vulgaris (CV) and Scenedesmus obliquus (SO) were the strains used for water treatment. Toxic effects on zebrafish embryo caused by effluents from microalgae treatment were compared with those observed under exposure to expe ...
DOI:
10.3390/w11091929

6. Acid-stimulated bioassembly of high-performance quantum dots in Escherichia coli

Author:
Li-Jiao Tian; Wen-Wei Li; Ting-Ting Zhu; Guo-Hua Zhao; Xian-Wei Liu; Jun-Cai Dong; Peng-Fei An; Jing-Yuan Ma; Fang Shen; Chen Qian; Bing Hu; Han-Qing Yu
Source:
Journal of materials chemistry A 2019 v.7 no.31 pp. 18480-18487
ISSN:
2050-7496
Subject:
Danio rerio; Escherichia coli; biocompatibility; cadmium; fluorescence; pH; quantum dots; reactive oxygen species; thiols
Abstract:
... Biogenic quantum dots (Bio-QDs) with good luminescence properties and inherent biocompatibility are highly desirable for life science studies and hybrid solar-to-chemical production applications, but controlled bio-assembly is still challenging. Here, we report a facile and effective acid stimulation strategy that enables drastically enhanced production of CdSₓSe₁₋ₓ Bio-QDs in Escherichia coli. Lo ...
DOI:
10.1039/c9ta06136c

7. Acridone Derivate Simultaneously Featuring Multiple Functions and Its Applications

Author:
Yaokun Xia; Wenhui He; Juan Li; Lupeng Zeng; Tingting Chen; Yijuan Liao; Weiming Sun; Jianming Lan; Shuangmu Zhuo; Jing Zhang; Huanghao Yang; Jinghua Chen
Source:
Analytical chemistry 2019 v.91 no.13 pp. 8406-8414
ISSN:
1520-6882
Subject:
Danio rerio; copper; electrochemistry; enzymes; exosomes; fluorescence; image analysis; models; neoplasms; organic matter; photostability; protein content; river water
Abstract:
... Compared with plenty of single-functional molecules, multifunctional molecules are scarce and have high demand in further research. In this work, a multifunctional molecule called 10-methyl-2-amino-acridone (MAA) is presented. Interestingly, MAA simultaneously features electrochemistry, two-photon fluorescence, visible-light-induced oxidase mimic, and photoelectrochemistry (PEC) activity, and the ...
DOI:
10.1021/acs.analchem.9b01289

8. Activation of the nucleotide excision repair pathway by crude oil exposure: A translational study from model organisms to the Hebei Spirit Oil Spill Cohort

Author:
Youngho Kim; Jaeseong Jeong; Nivedita Chatterjee; Un Hyuk Yim; Jung-Hwan Kwon; Myung-Sook Park; Jinhee Choi
Source:
Environmental pollution 2019 v.254 pp. 112997
ISSN:
0269-7491
Subject:
Caenorhabditis elegans; DNA; DNA damage; DNA repair; Danio rerio; RNA interference; blood sampling; fish; genes; human health; humans; models; oil spills; oils; petroleum; polycyclic aromatic hydrocarbons; screening; toxicity; toxicity testing; China
Abstract:
... In order to gain insight into the human health implications of the Hebei Spirit Oil Spill (HSOS), the mechanism of toxicity of the Iranian heavy crude (IHC), the main oil component in the HSOS was investigated in Caenorhabditis elegans and zebrafish. The identified mechanism was translated to humans using blood samples from Taean residents, who experienced HSOS with different levels of exposure to ...
DOI:
10.1016/j.envpol.2019.112997

9. Acute exposure to environmentally relevant concentrations of Chinese PFOS alternative F-53B induces oxidative stress in early developing zebrafish

Author:
Yongming Wu; Jing Huang; Mi Deng; Yuanxiang Jin; Huilin Yang; Yu Liu; Qinyan Cao; Jan A. Mennigen; Wenqing Tu
Source:
Chemosphere 2019 v.235 pp. 945-951
ISSN:
0045-6535
Subject:
Danio rerio; acute exposure; antioxidant activity; antioxidant enzymes; aquatic environment; embryo (animal); fish; genes; glutathione; larvae; malondialdehyde; mechanism of action; messenger RNA; oxidative stress; perfluorooctane sulfonic acid; phosphatidylinositol 3-kinase; protein content; stress response
Abstract:
... 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), a Chinese PFOS alternative, has recently been identified in the aquatic environment at concentrations similar to or higher than perfluorooctane sulfonate (PFOS). Although previous studies have shown that F-53B can trigger oxidative stress in fish, the underlying molecular mechanism is still largely unknown. In this study, zebrafish embryos w ...
DOI:
10.1016/j.chemosphere.2019.07.016

10. Acute exposure to ustiloxin A affects growth and development of early life zebrafish, Danio rerio

Author:
Zheng Hu; Yao Dang; Chunsheng Liu; Ligang Zhou; Hao Liu
Source:
Chemosphere 2019 v.226 pp. 851-857
ISSN:
0045-6535
Subject:
Danio rerio; Ustilaginoidea virens; acute exposure; animals; dose response; food security; gene expression regulation; genes; hatching; heart rate; larvae; messenger RNA; models; mortality; plant pathogenic fungi; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; rice; rice false smut; spikelets; toxicity; transcriptomics; ustiloxins
Abstract:
... Ustiloxin A is a cyclopeptide mycotoxin originally isolated from rice false smut balls (FSBs) that formed in rice spikelets infected by the fungal pathogen Ustilaginoidea virens. Studies have shown that ustiloxin A was toxic to animals, but the toxicological evidence is still lacking. To reveal the negative influence of ustiloxin A on model organism, zebrafish were selected and exposed to ustiloxi ...
DOI:
10.1016/j.chemosphere.2019.04.002

11. Acute stress alters the rates of degradation of cardiac muscle proteins

Author:
Bethany Geary; Kieran Magee; Phillip Cash; Holger Husi; Iain S. Young; Phillip D. Whitfield; Mary K. Doherty
Source:
Journal of proteomics 2019 v.191 pp. 124-130
ISSN:
1874-3919
Subject:
Danio rerio; environmental factors; gluconeogenesis; glucose; human health; humans; hypoxia; models; muscle protein; myocardium; peroxisome proliferator-activated receptors; phenotype; protein content; protein degradation; protein metabolism; signal transduction; social behavior; stress response
Abstract:
... Stressful experiences can have detrimental effects on many aspects of health and wellbeing. The zebrafish (Danio rerio) is a widely used model for stress research and a stress phenotype can be induced by manipulating the environmental conditions and social interactions. In this study we have combined a zebrafish stress model with the measurement of degradation rates of soluble cardiac muscle prote ...
DOI:
10.1016/j.jprot.2018.03.015

12. Additives migrating from 3D-printed plastic induce developmental toxicity and neuro-behavioural alterations in early life zebrafish (Danio rerio)

Author:
Milanga Walpitagama; Megan Carve; Alon M. Douek; Charlene Trestrail; Yutao Bai; Jan Kaslin; Donald Wlodkowic
Source:
Aquatic toxicology 2019 v.213 pp. 105227
ISSN:
0166-445X
Subject:
Danio rerio; acetylcholinesterase; additives; apoptosis; ascorbic acid; caspases; embryogenesis; environmental assessment; environmental hazards; environmental impact; enzyme inhibitors; gas chromatography-mass spectrometry; glutathione transferase; habituation; larvae; leachates; lethal concentration 50; lipid peroxidation; locomotion; mortality; motor neurons; muscles; neurotoxicity; paralysis; phenotype; plastics; risk assessment; superoxide dismutase; teratogenicity; toxic substances; wastes
Abstract:
... The environmental impact of exposure to 3D-printed plastics as well as potential migration of toxic chemicals from 3D-printed plastics remains largely unexplored. In this work we applied leachates from plastics fabricated using a stereolithography (SLA) process to early developmental stages of zebrafish (Danio rerio) to investigate developmental toxicity and neurotoxicity. Migration of unpolymeriz ...
DOI:
10.1016/j.aquatox.2019.105227

13. Advancing the Zebrafish embryo test for endocrine disruptor screening using micro‐injection: Ethinyl estradiol as a case study

Author:
Ellen D. G. Michiels; Lucia Vergauwen; Foon Yin Lai; Raewyn M. Town; Adrian Covaci; Alexander L. N. van Nuijs; Steven J. Van Cruchten; Dries Knapen
Source:
Environmental toxicology and chemistry 2019 v.38 no.3 pp. 533-547
ISSN:
0730-7268
Subject:
Danio rerio; abnormal development; absorbed dose; aromatase; biomarkers; brain; case studies; dose response; droplet size; embryo (animal); endocrine-disrupting chemicals; estradiol; estrogen receptors; exposure pathways; fish; guidelines; hydrophobicity; models; screening; solvents; toxicity testing; vitellogenin
Abstract:
... Fish (embryo) toxicity test guidelines are mostly based on aquatic exposures. However, in some cases, other exposure routes can be more practical and relevant. Micro‐injection into the yolk of fish embryos could offer a particular advantage for administering hydrophobic compounds, such as many endocrine disruptors. Single‐dose micro‐injection was compared with continuous aquatic exposure in terms ...
DOI:
10.1002/etc.4343

14. Adverse effects induced by chronic gamma irradiation in progeny of adult fish not affecting parental reproductive performance

Author:
Noémie Guirandy; Béatrice Gagnaire; Sandrine Frelon; Thomas Munch; Nicolas Dubourg; Virginie Camilleri; Isabelle Cavalié; Magali Floriani; Caroline Arcanjo; Sophia Murat El Houdigui; Olivier Armant; Christelle Adam‐Guillermin; Patrice Gonzalez; Olivier Simon
Source:
Environmental toxicology and chemistry 2019 v.38 no.11 pp. 2556-2567
ISSN:
0730-7268
Subject:
DNA; Danio rerio; adults; adverse effects; cesium radioisotopes; ecotoxicology; eggs; environmental assessment; fecundity; fish; gamma radiation; irradiation; larvae; long term effects; mortality; progeny; reactive oxygen species; reproductive performance; reproductive success; risk assessment
Abstract:
... Multigenerational studies have become of great interest in ecotoxicology since the consequence of parental exposure to contaminants on offspring generations was established in situ or in laboratory conditions. The present study mainly examined the chronic effects of external Cs‐137 gamma irradiation exposure at 4 dose rates (control, 0.5, 5, and 50 mGy h–¹) on adult zebrafish (F0) exposed for 10 d ...
DOI:
10.1002/etc.4562

15. Adverse effects of p-TSA-doped polypyrrole particulate exposure during zebrafish (Danio rerio) development

Author:
Kesiane M. Costa; Talita C.B. Pereira; Cristhiane A. Valente; Kenia Pissinate; Jéssica C. Soares; Fernanda F. Cruz; Temis W.F. Corte; Pablo Machado; Nara R.S. Basso; Maurício R. Bogo
Source:
Colloids and surfaces 2019 v.177 pp. 58-67
ISSN:
0927-7765
Subject:
in vivo studies; heart rate; locomotion; dose response; nanomaterials; chorion; colloids; pyrroles; nanomedicine; hatching; body length; mortality; polymers; larvae; Danio rerio; embryogenesis; sulfonic acids; adverse effects
Abstract:
... Nanomaterials have been attracting attention due to the wide range of applications in nanomedicine. Polypyrrole (PPy), a conductive polymer, has been employed in the biomedical field due to its stimulus-responsive properties, although in vivo studies to assess its potential undesirable effects are limited. This study evaluated the effects of PPy doped with p-toluene sulfonic acid ((p-TSA); PPy/p-T ...
DOI:
10.1016/j.colsurfb.2019.01.041

16. Agaricus bisporus-derived β-glucan prevents obesity through PPAR γ downregulation and autophagy induction in zebrafish fed by chicken egg yolk

Author:
Xiumin Li; Yu Xue; Liang Pang; Bo Len; Zhichao Lin; Jiafu Huang; Zhaoshui ShangGuan; Yutian Pan
Source:
International journal of biological macromolecules 2019 v.125 pp. 820-828
ISSN:
0141-8130
Subject:
Agaricus bisporus; Danio rerio; adipocytes; adiposity; autophagy; beta-glucans; diet; dose response; egg yolk; larvae; lipid metabolism; lipids; obesity; peroxisome proliferator-activated receptor gamma
Abstract:
... β-(1,4)-d-Glucan with (1,2) and (1,6)-linked branches (short for β-glucan), extracted from Agaricus bisporus (Lange) Sing, had significant anti-obesity and lowering-fat effect. FITC-β-glucan was absorbed by adipocytes of zebrafish larvae when stained by Nile Red. β-Glucan decreased the adiposity mass, reduced the expression of ppar g, mtp, L-fabp, ifabp in ISH, which was coincident as the results ...
DOI:
10.1016/j.ijbiomac.2018.12.122

17. AhR Agonist Activity Confirmation of Polyhalogenated Carbazoles (PHCZs) Using an Integration of in Vitro, in Vivo, and in Silico Models

Author:
Chenyang Ji; Chao Shen; Yixi Zhou; Kongyang Zhu; Zhe Sun; Zhenghong Zuo; Meirong Zhao
Source:
Environmental science & technology 2019 v.53 no.24 pp. 14716-14723
ISSN:
1520-5851
Subject:
Danio rerio; agonists; aryl hydrocarbon receptors; bioassays; carbazoles; computer simulation; gene expression; gene expression regulation; human cell lines; in vitro studies; in vivo studies; pollutants; tetrachlorodibenzo-p-dioxin; toxicity; transgenic animals
Abstract:
... Polyhalogenated carbazoles (PHCZs) are a kind of rising environmental pollutant that has been reported to pose high risk to human beings and the natural environment. PHCZs are of a similar molecular structure with of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and exhibited some dioxin-like toxicity. Dioxin-like compounds (DLCs) are banned by the Stockholm Convention due to their potential adverse ...
DOI:
10.1021/acs.est.9b05388

18. Allelopathically inhibitory effects of eucalyptus extracts on the growth of Microcystis aeruginosa

Author:
Wei Zhao; Zheng Zheng; JunLei Zhang; Saint-Fort Roger; XingZhang Luo
Source:
Chemosphere 2019 v.225 pp. 424-433
ISSN:
0045-6535
Subject:
Danio rerio; Eucalyptus grandis; Microcystis aeruginosa; algae; allelochemicals; aquatic environment; berberine; cell membranes; ecophysiology; enzyme activity; enzyme inhibition; esterases; eutrophication; gallic acid; grasses; leaves; mechanism of action; photosynthesis; roots; species abundance; stems; surface water; synergism; toxicity; Washington (state)
Abstract:
... Microcystis aeruginosa (M. aeruginosa), as the dominant algae in eutrophic water bodies, has caused a serious harm to the local eco-environment. A biological tool, employing allelopathic inhibitory of eucalyptus to control M. aeruginosa, has been receiving tremendous attention. This work presents the results of the allelopathic inhibitory effects of eucalyptus (Eucalyptus grandis × E.urophylla ‘GL ...
DOI:
10.1016/j.chemosphere.2019.03.070

19. Alleviative Effects of C₆₀ on the Trophic Transfer of Cadmium along the Food Chain in Aquatic Environment

Author:
Zuohong Chen; Xiaoshan Zhu; Xiaohui Lv; Yuxiong Huang; Wei Qian; Pu Wang; Bing Li; Zhenyu Wang; Zhonghua Cai
Source:
Environmental science & technology 2019 v.53 no.14 pp. 8381-8388
ISSN:
1520-5851
Subject:
Danio rerio; Daphnia magna; aquatic environment; bioaccumulation; cadmium; dietary exposure; digestive physiology; food chain; technology; trophic levels
Abstract:
... C₆₀ could enhance the accumulation of pollutants in organisms, but their effects on higher trophic levels remain unknown. In the present study, the transfer of C₆₀ from Daphnia magna to zebrafish (Danio rerio) and its effects on Cd transfer were investigated. The results showed that C₆₀ could be transferred from D. magna to zebrafish through dietary exposure and accumulate mainly in the intestines ...
DOI:
10.1021/acs.est.9b01636

20. Altered Gene expression of ABC transporters, nuclear receptors and oxidative stress signaling in zebrafish embryos exposed to CdTe quantum dots

Author:
Jingjing Tian; Jia Hu; Guangxing Liu; Huancai Yin; Mingli Chen; Peng Miao; Pengli Bai; Jian Yin
Source:
Environmental pollution 2019 v.244 pp. 588-599
ISSN:
0269-7491
Subject:
Danio rerio; P-glycoproteins; adenosine; biomarkers; embryo (animal); gene expression regulation; glutathione; hatching; oxidative stress; peroxisome proliferator-activated receptors; pollutants; pregnanes; protective effect; quantum dots; superoxide dismutase; toxicity
Abstract:
... Adenosine triphosphate-binding cassette (ABC) transporters, including P-glycoprotein (Pgp) and multi-resistance associated proteins (Mrps), have been considered important participants in the self-protection of zebrafish embryos against environmental pollutants, but their possible involvement in the efflux and detoxification of quantum dots (QDs), as well as their regulation mechanism are currently ...
DOI:
10.1016/j.envpol.2018.10.092

21. Altered plant organogenesis under boron deficiency is associated with changes in high-mannose N-glycan profile that also occur in animals

Author:
María Reguera; Isidro Abreu; Carlos Sentís; Ildefonso Bonilla; Luis Bolaños
Source:
Journal of plant physiology 2019 v.243 pp. 153058
ISSN:
0176-1617
Subject:
Arabidopsis thaliana; Danio rerio; Pisum sativum; animal physiology; boron; cell differentiation; cell walls; concanavalin A; early development; fish larvae; glycoconjugates; glycosylation; mannose; organogenesis; plants (botany); root meristems
Abstract:
... Boron (B) deficiency affects the development of Pisum sativum nodules and Arabidopsis thaliana root meristems. Both organs show an alteration of cell differentiation that result in the development of tumor-like structures. The fact that B in plants is not only able to interact with components of the cell wall but also with membrane-associated glycoconjugates, led us to analyze changes in high mann ...
DOI:
10.1016/j.jplph.2019.153058

22. Analysis of the wnt1 regulatory chromosomal landscape

Author:
Arne C. Lekven; Craig J. Lilie; Holly C. Gibbs; David G. Green; Avantika Singh; Alvin T. Yeh
Source:
Development genes and evolution 2019 v.229 no.2-3 pp. 43-52
ISSN:
0949-944X
Subject:
Danio rerio; Lepisosteus oculatus; chromatin; embryogenesis; evolution; gene expression; gene regulatory networks; genomics; landscapes; loci; mesencephalon; neurogenesis; transcription (genetics); vertebrates; wnt proteins
Abstract:
... One of the earliest patterning events in the vertebrate neural plate is the specification of mes/r1, the territory comprising the prospective mesencephalon and the first hindbrain rhombomere. Within mes/r1, an interface of gene expression defines the midbrain–hindbrain boundary (MHB), a lineage restriction that separates the mesencephalon and rhombencephalon. wnt1 is critical to mes/r1 development ...
DOI:
10.1007/s00427-019-00629-5
PubMed:
30825002
PubMed Central:
PMC6500750

23. Angularly Prenylated Indole Alkaloids with Antimicrobial and Insecticidal Activities from an Endophytic Fungus Fusarium sambucinum TE-6L

Author:
Peng Zhang; Xiao-Long Yuan; Yong-Mei Du; Huai-Bao Zhang; Guo-Ming Shen; Zhong-Feng Zhang; Yu-Jun Liang; Dong-Lin Zhao; Kuo Xu
Source:
Journal of agricultural and food chemistry 2019 v.67 no.43 pp. 11994-12001
ISSN:
1520-5118
Subject:
Danio rerio; Fusarium sambucinum; Helicoverpa armigera; Nicotiana tabacum; X-ray diffraction; aquatic ecosystems; biosynthesis; circular dichroism spectroscopy; developmental toxicity; embryo (animal); endophytes; exposure assessment; hatching; humans; indole alkaloids; insect larvae; insecticidal properties; instars; larvicides; moieties; mortality; plant pathogenic bacteria; plant pathogenic fungi; toxicity testing
Abstract:
... Bioactivity-guided isolation of the endophytic fungus Fusarium sambucinum TE-6L residing in Nicotiana tabacum L. led to the discovery of two new angularly prenylated indole alkaloids (PIAs) with pyrano[2,3-g]indole moieties, amoenamide C (1) and sclerotiamide B (2), and four known biosynthetic congeners (3–6). Their structures were determined by comprehensive spectroscopic techniques, electronic c ...
DOI:
10.1021/acs.jafc.9b05827

24. Animal models of leukodystrophy: a new perspective for the development of therapies

Author:
Holly A. Rutherford; Noémie Hamilton
Source:
FEBS journal 2019 v.286 no.21 pp. 4176-4191
ISSN:
1742-464X
Subject:
Danio rerio; animal models; cognitive disorders; high-throughput nucleotide sequencing; humans; mice; pathogenesis; patients; signs and symptoms (animals and humans); therapeutics
Abstract:
... The leukodystrophies are a family of heritable disorders characterised by white matter degeneration, accompanied by variable clinical symptoms including loss of motor function and cognitive decline. Now thought to include over 50 distinct disorders, there are a vast array of mechanisms underlying the pathology of these monogenic conditions and, accordingly, a range of animal models relating to eac ...
DOI:
10.1111/febs.15060

25. Ankrd45 Is a Novel Ankyrin Repeat Protein Required for Cell Proliferation

Author:
Yunsi Kang; Haibo Xie; Chengtian Zhao
Source:
Genes 2019 v.10 no.6 pp. -
ISSN:
2073-4425
Subject:
CRISPR-Cas systems; Danio rerio; apoptosis; cell lines; cell proliferation; cilia; cytokinesis; early development; gene editing; genes; histology; human diseases; larvae; liver; mammals; mitosis; mutants; mutation; neoplasms; prokaryotic cells; proteins; small interfering RNA; tissues
Abstract:
... Ankyrin repeats, the most common protein–protein interaction motifs in nature, are widely present in proteins of both eukaryotic and prokaryotic cells. Ankyrin repeat-containing proteins play diverse biological functions. Here, we identified the gene ankrd45, which encodes a novel, two ankyrin repeat-containing protein. Zebrafish ankrd45 displayed a tissue specific expression pattern during ...
DOI:
10.3390/genes10060462
PubMed:
31208154
PubMed Central:
PMC6628321

26. Anti-Inflammatory Activity of a Peptide from Skipjack (Katsuwonus pelamis)

Author:
Zhi-gao Wang; Xiao-guo Ying; Peng Gao; Chun-li Wang; Yi-fan Wang; Xin-wei Yu; Jing Chen; Bin Wang; Hong-yu Luo
Source:
Marine drugs 2019 v.17 no.10 pp. -
ISSN:
1660-3397
Subject:
Danio rerio; Katsuwonus pelamis; adjuvants; anti-inflammatory activity; bacteria; blood serum; body weight changes; byproducts; colitis; colon; diarrhea; inflammation; interleukin-10; interleukin-6; intestinal microorganisms; mice; microscopy; models; neutrophils; probiotics; species diversity; sulfasalazine; therapeutics; tumor necrosis factor-alpha; villi; virulent strains
Abstract:
... In this paper, the effect of skipjack (Katsuwonus pelamis) enzymatic peptide (SEP), which was prepared and purified from a byproduct of skipjack, on inflammation, ulcerative colitis and the regulation of intestinal flora was studied in a mouse ulcerative colitis model and a transgenic zebrafish inflammation model. The aggregation of transgenic granulocyte neutrophils in zebrafish from a normal env ...
DOI:
10.3390/md17100582
PubMed:
31614893
PubMed Central:
PMC6835902

27. Anti-betanodavirus activity of isoprinosine and improved efficacy using carbon nanotubes based drug delivery system

Author:
Song Zhu; Jian Li; Ai-Guo Huang; Ji-Qiu Huang; Yong-Quan Huang; Gao-Xue Wang
Source:
Aquaculture 2019 v.512 pp. 734377
ISSN:
0044-8486
Subject:
Betanodavirus; Danio rerio; Fourier transform infrared spectroscopy; antiviral agents; apoptosis; aquaculture; bovine serum albumin; carbon nanotubes; central nervous system; drug delivery systems; drugs; etiological agents; fish larvae; freshwater fish; hosts; immune response; inhibitory concentration 50; interferon-gamma; interleukin-1beta; mortality; necrosis; transmission electron microscopes; tumor necrosis factor-alpha; ultraviolet-visible spectroscopy
Abstract:
... Viral nervous necrosis (VNN) disease has caused mass mortality in cultured marine and freshwater fish worldwide, resulting in enormous economic losses in the aquaculture industry. The causative agent of VNN is betanodavirus [also known as nervous necrosis virus (NNV)], which classified as a member of the Nodaviridae family. NNV mainly infects the central nervous system (CNS) of hosts, which is pro ...
DOI:
10.1016/j.aquaculture.2019.734377

28. Anti-inflammatory effects of aloe vera on soy meal-induced intestinal inflammation in zebrafish

Author:
K. Fehrmann-Cartes; M. Coronado; A.J. Hernández; M.L. Allende; C.G. Feijoo
Source:
Fish & shellfish immunology 2019 v.95 pp. 564-573
ISSN:
1050-4648
Subject:
Aloe vera; Danio rerio; anti-inflammatory activity; aquaculture industry; bacterial infections; farmed fish; fish health; fish meal; inflammation; ingestion; innate immunity; intestines; shellfish; soybean meal; soybeans
Abstract:
... Soybean meal is one of the most promising alternatives to replace fishmeal in the aquaculture industry. However, its ingestion triggers an intestinal inflammatory process that compromises fish health and nutrition. Therefore, finding strategies that reduce the deleterious effects of a soy protein-based diet are relevant. In this work we analyzed the effects of an aloe vera (Aloe barbadensis miller ...
DOI:
10.1016/j.fsi.2019.10.075

29. Anti-melanogenesis of novel kojic acid derivatives in B16F10 cells and zebrafish

Author:
Yan-Mei Chen; Wei-Chao Su; Chen Li; Yan Shi; Qing-Xi Chen; Jing Zheng; Dong-Lei Tang; Shu-Ming Chen; Qin Wang
Source:
International journal of biological macromolecules 2019 v.123 pp. 723-731
ISSN:
0141-8130
Subject:
Danio rerio; binding proteins; cAMP-dependent protein kinase; catechol oxidase; cosmetics; enzyme activity; enzyme inhibition; food science; inhibitory concentration 50; kojic acid; medicine; melanin; models; nuclear magnetic resonance spectroscopy; phosphorylation; pigmentation; transcription factors
Abstract:
... Novel kojic acid derivatives (KADs) with the potential ability to inhibit tyrosinase were synthesized and were further identified by Q-Exactive, IR and NMR. Among these compounds, KAD2 showed the best inhibitory effects on diphenolase activity and monophenolase activity, with IC₅₀ of 7.50 μM and 20.51 μM, respectively. The anti-melanogenic activity of KAD2 was further confirmed by assessing the in ...
DOI:
10.1016/j.ijbiomac.2018.11.031

30. Antiangiogenic Activity of Compounds Isolated from Anarrhinum pedatum

Author:
Khadidja Aya Beladjila; Djemaa Berrehal; Zahia Kabouche; Maria Paola Germanò; Valeria D’Angelo; Nunziatina De Tommasi; Felicia D’Andrea; Alessandra Braca; Marinella De Leo
Source:
Journal of natural products 2019 v.82 no.3 pp. 510-519
ISSN:
1520-6025
Subject:
Anarrhinum; Danio rerio; aerial parts; blood vessels; butanol; chickens; embryo (animal); iridoid glycosides; models; monoterpenoids; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Ten new iridoid glycosides (1–10) and two new monoterpenoids (11 and 12), together with nine known compounds (13–21), were isolated from the n-butanol extract of the aerial parts of Anarrhinum pedatum. The structural characterization of all compounds was performed by spectroscopic analysis, including 1D and 2D NMR and HRESIMS experiments. The isolates were assayed for their antiangiogenic activity ...
DOI:
10.1021/acs.jnatprod.8b00893

31. Antiangiogenic phenylpropanoid glycosides from Gynura cusimbua

Author:
Qinge Ma; Rongrui Wei; Bin Zhou; Zhipei Sang; Wenmin Liu; Zhongling Cao
Source:
Natural product research 2019 v.33 no.4 pp. 457-463
ISSN:
1478-6427
Subject:
Danio rerio; Gynura cusimbua; butanol; glycosides; models; spectral analysis; toxicity testing
Abstract:
... A new phenylpropanoid glycoside, named α-L-rhamnopyranosyl-(1↔2)-β-D-[4″-(8E)-7-(3,4-dihydroxyphenyl)-8-propenoate, 1″-O-(7S)-7-(3,4-dihydroxyphenyl)-7-methoxy-ethyl]-glucopyranoside (1), together with nine known compounds (2–10) were isolated from the active fraction (n-Butanol fraction) of Gynura cusimbua for the first time. The known compounds (2–10) were identified as phenylpropanoid glycoside ...
DOI:
10.1080/14786419.2017.1389931

32. Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity

Author:
Shahida Parveen; Muhammad Hanif; Euphemia Leung; Kelvin K. H. Tong; Annie Yang; Jonathan Astin; Gayan H. De Zoysa; Tasha R. Steel; David Goodman; Sanam Movassaghi; Tilo Söhnel; Vijayalekshmi Sarojini; Stephen M. F. Jamieson; Christian G. Hartinger
Source:
Chemical communications 2019 v.55 no.80 pp. 12016-12019
ISSN:
1364-548X
Subject:
DNA damage; Danio rerio; antineoplastic activity; chemical compounds; chemical reactions; cisplatin; hemolysis; mechanism of action; models; neoplasm cells; neoplasms; reactive oxygen species; toxicity
Abstract:
... Redox-modulating anticancer drugs allow the exploitation of altered redox biology observed in many cancer cells. We discovered dinuclear Rhᴵᴵᴵ(Cp*) and Irᴵᴵᴵ(Cp*) complexes that have in vitro anticancer activity superior to cisplatin and the investigational drug IT-139, while being less toxic in haemolysis and in vivo zebrafish models. The mode of action appears to be related to DNA damage and ROS ...
DOI:
10.1039/c9cc03822a

33. Antioxidant and anti-inflammatory effects of an ethanol fraction from the Schisandra chinensis baillon hot water extract fermented using Lactobacilius paracasei subsp. tolerans

Author:
Jung Yoon Yang; Geum Ran Kim; Jin Sil Chae; Hyemin Kan; Seong Soon Kim; Kyu-Seok Hwang; Byung Hoi Lee; Sangcheol Yu; Seongcheol Moon; Byounghee Park; Myung Ae Bae; Dae-Seop Shin
Source:
Food science and biotechnology 2019 v.28 no.6 pp. 1759-1767
ISSN:
1226-7708
Subject:
Danio rerio; Schisandra chinensis; antioxidants; biotechnology; byproducts; ethanol; fermentation; food industry; food science; gene expression; immune response; interleukin-6; lipopolysaccharides; neutrophils; nitric oxide; protein secretion; waste management
Abstract:
... Waste management is a major part of the food industry. The present study was designed to utilize the discarded byproduct of Schisandra chinensis Baillon. The antioxidant and anti-inflammatory effects of a 30% ethanol fraction (RPG-OM-30E) from the fermented hot water extraction of the Schisandra chinensis Baillon byproduct were investigated using RAW 264.7 cells and zebrafish larvae. RPG-OM-30E re ...
DOI:
10.1007/s10068-019-00626-4
PubMed:
31807348
PubMed Central:
PMC6859149

34. Antioxidant properties of a sulfated polysaccharide isolated from an enzymatic digest of Sargassum thunbergii

Author:
Min-Cheol Kang; HyoGeun Lee; Hee-Don Choi; You-Jin Jeon
Source:
International journal of biological macromolecules 2019 v.132 pp. 142-149
ISSN:
0141-8130
Subject:
Danio rerio; Sargassum thunbergii; antioxidant activity; cell lines; chromatography; cosmetics; free radical scavengers; functional foods; hydrogen peroxide; ion exchange; oxidative stress; polysaccharides; protective effect; proteinases
Abstract:
... The protective effect of sulfated polysaccharides (PS-4) isolated from Sargassum thunbergii against oxidative stress in cells and zebrafish was investigated. To begin, a variety of enzymatic extraction methods were used, including five carbohydrases and four proteases. Among the enzymatic extracts, the S. thunbergii Celluclast-assisted extract (STC) demonstrated the strongest scavenging activities ...
DOI:
10.1016/j.ijbiomac.2019.03.178

35. Antiviral activity of anisomycin against spring viraemia of carp virus in epithelioma papulosum cyprini cells and zebrafish

Author:
Yu-Feng Shen; Yang Hu; Bin Zhu; Gao-Xue Wang
Source:
Virus research 2019 v.268 pp. 38-44
ISSN:
0168-1702
Subject:
Carp sprivivirus; Danio rerio; Streptomyces griseolus; antiviral properties; aquaculture; carp; cytopathogenicity; gene expression; glycoproteins; inhibitory concentration 50; intraperitoneal injection; kidneys; messenger RNA; metabolites; nucleoproteins; phosphoproteins; spleen; survival rate; therapeutics; viremia
Abstract:
... Spring viraemia of carp (SVC) caused by spring viraemia of carp virus (SVCV) is an acute and highly lethal viral disease of cyprinid fish. However, effective therapy for SVC is still scarce until now. Here we evaluated the inhibition of anisomycin (Ani), a metabolite produced by Streptomyces griseolus, on the replication of SVCV in vitro and in vivo. Our results demonstrated that Ani could suppres ...
DOI:
10.1016/j.virusres.2019.05.013
PubMed:
31136824
PubMed Central:
PMC7114655

36. Antiviral activity of palmitic acid via autophagic flux inhibition in zebrafish (Danio rerio)

Author:
Marta Librán-Pérez; Patricia Pereiro; Antonio Figueras; Beatriz Novoa
Source:
Fish & shellfish immunology 2019 v.95 pp. 595-605
ISSN:
1050-4648
Subject:
Carp sprivivirus; Danio rerio; antiviral properties; autophagy; cell proliferation; fish; immune response; immunostimulants; interferons; models; morbidity; mortality; neutrophils; nutrition; palmitic acid; viral load
Abstract:
... Fatty acids (FAs) are key elements that affect not only growth but also different immune functions, and therefore, nutrition is important for growing healthy fish. Zebrafish (Danio rerio) is a good model for assessing the beneficial effects of immunostimulants, including FAs, before applying them in aquaculture. Accordingly, this study evaluated the effects of palmitic acid (PA) treatment on diffe ...
DOI:
10.1016/j.fsi.2019.10.055

37. Antiviral efficiency of a coumarin derivative on spring viremia of carp virus in vivo

Author:
Guanglu Liu; Chunjie Wang; Haifeng Wang; Lili Zhu; Hui Zhang; Yunsheng Wang; Chaoyu Pei; Lei Liu
Source:
Virus research 2019 v.268 pp. 11-17
ISSN:
0168-1702
Subject:
Carp sprivivirus; Danio rerio; antiviral agents; aquaculture; carp; coumarin; dose response; half life; models; mortality; pathogenicity; signal transduction; therapeutics; viral load; viremia
Abstract:
... Spring viraemia of carp (SVC) in aquaculture is challenging because there are few preventative measures and/or treatments. The previous study demonstrated that an antiviral coumarin derivative, 7-(4-(4-methyl-imidazole))-coumarin (C2), inhibits spring viremia of carp virus (SVCV) infection by targeting Nrf2-ARE signaling pathway in fish cells. Thus, we hypothesized whether C2 may be used as a pote ...
DOI:
10.1016/j.virusres.2019.05.007

38. Application of general toxic effects of ionic liquids to predict toxicities of ionic liquids to Spodoptera frugiperda 9, Eisenia fetida, Caenorhabditis elegans, and Danio rerio

Author:
Chul-Woong Cho; Yeoung-Sang Yun
Source:
Environmental pollution 2019 pp. -
ISSN:
0269-7491
Subject:
Caenorhabditis elegans; Danio rerio; Eisenia fetida; Gibbs free energy; Spodoptera frugiperda; cell lines; data collection; earthworms; fish; insects; ionic liquids; lethal concentration 50; models; prediction; toxicity
Abstract:
... Modeling for the toxicity of ionic liquids (ILs) is necessary to fill data gaps for untested chemicals and to understand the relevant mechanisms at the molecular level. In order for many researchers to easily predict toxicity and/or develop some prediction model, simple method(s) based on a single parameter should be proposed. Therefore, previously our group developed a comprehensive toxicity pred ...
DOI:
10.1016/j.envpol.2019.113185

39. Aryl hydrocarbon receptor mediates the cardiac developmental toxicity of EOM from PM2.5 in P19 embryonic carcinoma cells

Author:
Tao Chen; Hongmei Jin; Huimin Wang; Yugang Yao; Stanley Aniagu; Jian Tong; Yan Jiang
Source:
Chemosphere 2019 v.216 pp. 372-378
ISSN:
0045-6535
Subject:
DNA; Danio rerio; antagonists; apoptosis; beta catenin; carcinoma; cell proliferation; developmental toxicity; embryo (animal); fluorescent antibody technique; gene expression regulation; heart abnormalities; mice; myocardium; neoplasm cells; organic matter; particulates; quantitative polymerase chain reaction; stem cells
Abstract:
... Ambient fine particulate matter (PM2.5) has been found to be associated with congenital heart defects, but the molecular mechanisms remain to be elucidated. Our previous study revealed that extractable organic matter (EOM) from PM2.5 exerted cardiac developmental toxicity in zebrafish embryos. The aim of the current study is to explore the effects of EOM on cardiac differentiation of P19 mouse emb ...
DOI:
10.1016/j.chemosphere.2018.10.160

40. Assessing pH-dependent toxicity of fluoxetine in embryonic zebrafish using mass spectrometry-based metabolomics

Author:
Priti Mishra; Zhiyuan Gong; Barry C. Kelly
Source:
Science of the total environment 2019 v.650 pp. 2731-2741
ISSN:
0048-9697
Subject:
Danio rerio; amino acid metabolism; apoptosis; aquatic organisms; embryo (animal); energy; energy metabolism; excretion; gas chromatography-mass spectrometry; glucose; lipid metabolism; metabolites; metabolomics; multivariate analysis; oxidative stress; pH; toxicity; urea; wastes
Abstract:
... While it is well known that fluoxetine is more toxic to aquatic organisms at high pH, the metabolic dysregulations related to observed pH-dependent effects are still poorly understood. In the present study, we utilized a gas chromatography mass spectrometry (GC–MS) based metabolomics approach to assess metabolomic profile changes in developing zebrafish embryos following exposure (2 hpf–96 hpf) to ...
DOI:
10.1016/j.scitotenv.2018.09.364

41. Assessing the ability of zebrafish scales to contribute to the short-term homeostatic regulation of [Ca2+] in the extracellular fluid during calcemic challenges

Author:
Jacky T. Hung; Sarah E. Webb; Carla Palumbo; Agnieszka M. Lesniak; Alan M. Shipley; Alessandro Rubinacci; Joseph G. Kunkel; Andrew L. Miller
Source:
Fisheries science 2019 v.85 no.6 pp. 943-959
ISSN:
0919-9268
Subject:
Danio rerio; calcium; fish; fish culture; homeostasis; ions; mice; models; scales (integument); specific ion electrodes
Abstract:
... The elasmoid scales of fish represent a significant internal reservoir of calcium ions (Ca²⁺), but little is known about the contribution of these scales to the short-term regulation of Ca²⁺ homeostasis in the extracellular fluid (ECF). This gap in our knowledge is partly due to the technical challenges involved in measuring small Ca²⁺ fluxes around the scales of live fish in real time. Here, we d ...
DOI:
10.1007/s12562-019-01353-9

42. Assessment of impacts of diphenyl phosphate on groundwater and near-surface environments: Sorption and toxicity

Author:
Sean P. Funk; Lisa Duffin; Yuhe He; Craig McMullen; Chenxing Sun; Nicholas Utting; Jonathan W. Martin; Greg G. Goss; Daniel S. Alessi
Source:
Journal of contaminant hydrology 2019 v.221 pp. 50-57
ISSN:
0169-7722
Subject:
Danio rerio; aquatic ecosystems; chickens; cytotoxicity; embryo (animal); energy; environmental fate; flame retardants; groundwater; hepatocytes; hydraulic fracturing; industry; lubricants; messenger RNA; oxidants; phosphates; plasticizers; risk; sediments; soil; sorption; streams; wastewater; Alberta
Abstract:
... Wastewater recovered from hydraulic fracturing is referred to as flowback and produced water (FPW), and is often saline, contains numerous organic and inorganic constituents, and may pose threats to groundwater resources. Hundreds of spills of FPW have been reported to the Alberta Energy Regulator each year. Recently, samples of FPW derived from hydraulic fracturing of the Duvernay Formation, AB, ...
DOI:
10.1016/j.jconhyd.2019.01.002

43. Assessment of the effect of methyl-triclosan and its mixture with triclosan on developing zebrafish (Danio rerio) embryos using mass spectrometry-based metabolomics

Author:
Jing Fu; Zhiyuan Gong; Sungwoo Bae
Source:
Journal of hazardous materials 2019 v.368 pp. 186-196
ISSN:
0304-3894
Subject:
Danio rerio; acetonitrile; bioavailability; biodegradation; databases; embryo (animal); gas chromatography-mass spectrometry; glucose; hydrophobicity; isopropyl alcohol; mannose; metabolism; metabolites; metabolome; metabolomics; multivariate analysis; pentose phosphate cycle; starch; sucrose; toxicity; toxicity testing; triclosan; valine; watersheds
Abstract:
... Methyl-triclosan (MTCS), as a biodegradation product from antibacterial triclosan (TCS), has been detected in water catchments, and it has also been verified to accumulate in biota due to its hydrophobicity. There is a lack, however, of toxicity studies on MTCS and its effects on organisms in conjunction with TCS. In this study, exposure experiments were conducted to assess the toxicity to embryon ...
DOI:
10.1016/j.jhazmat.2019.01.019

44. Assessment of tissue-specific multifactor effects in environmental –omics studies of heterogeneous biological samples: Combining hyperspectral image information and chemometrics

Author:
Víctor Olmos; Mónica Marro; Pablo Loza-Alvarez; Demetrio Raldúa; Eva Prats; Benjamí Piña; Romà Tauler; Anna de Juan
Source:
Talanta 2019 v.194 pp. 390-398
ISSN:
0039-9140
Subject:
Danio rerio; chemometrics; exposure duration; eyes; hyperspectral imagery; larvae; least squares; melanin; models; phenotype
Abstract:
... The use of hyperspectral imaging techniques in biological studies has increased in the recent years. Hyperspectral images (HSI) provide chemical information and preserve the morphology and original structure of heterogeneous biological samples, which can be potentially useful in environmental –omics studies when effects due to several factors, e.g., contaminant exposure, phenotype,…, at a specific ...
DOI:
10.1016/j.talanta.2018.10.029

45. Attenuated Listeria monocytogenes protecting zebrafish (Danio rerio) against Vibrio species challenge

Author:
Chengchao Ding; Qing Liu; Jie Li; Junfei Ma; Shuying Wang; Qingli Dong; Dongpo Xu; Jingxuan Qiu; Xiang Wang
Source:
Microbial pathogenesis 2019 v.132 pp. 38-44
ISSN:
0882-4010
Subject:
Danio rerio; Listeria monocytogenes; Vibrio alginolyticus; Vibrio anguillarum; Vibrio parahaemolyticus; antigens; aquaculture; aquaculture industry; bacteria; cross immunity; fish; fish diseases; intraperitoneal injection; live vaccines; models; outer membrane proteins; survival rate; vector vaccines; vibriosis
Abstract:
... Live attenuated bacteria is a promising candidate vector for the delivery of vaccines in clinic trials. In the field of aquaculture industry, live vector vaccine also could provide long-term and effective protection against fish bacterial diseases. In our previous work, we demonstrated attenuated Listeria monocytogenes (Lm) had the potential to be an aquaculture vaccine vector in cellular level an ...
DOI:
10.1016/j.micpath.2019.03.040

46. Behavioral effects in adult zebrafish after developmental exposure to carbaryl

Author:
Daniela Correia; Ana Rita Almeida; Joana Santos; Ana Luísa Machado; Olga Koba Ucun; Vladimír Žlábek; Miguel Oliveira; Inês Domingues
Source:
Chemosphere 2019 v.235 pp. 1022-1029
ISSN:
0045-6535
Subject:
Danio rerio; adulthood; adults; carbaryl; embryo (animal); fish; fish behavior; locomotion; risk; social behavior; thigmotaxis
Abstract:
... Chemical exposure during the early life stages of development may have long lasting effects on organisms that are rarely studied. The present work intended to evaluate the effect of embryonic exposure to the pesticide carbaryl on adult fish behavior. Zebrafish (Danio rerio) embryos were exposed, for 4 days, to sublethal concentrations of carbaryl (0.01, 0.1 and 1.0 mg/L) plus a control and then ke ...
DOI:
10.1016/j.chemosphere.2019.07.029

47. Behavioral studies of stimulus learning in zebrafish larvae

Author:
Ruth M. Colwill
Source:
Behavioural processes 2019 v.164 pp. 150-156
ISSN:
0376-6357
Subject:
Danio rerio; larvae; learning
Abstract:
... Within a week of fertilization, a zebrafish larva has developed a robust behavioral repertoire that includes the ability to learn about noncontingent stimuli. I begin this paper with a brief review of the t1-t2 framework in which groups receive different experiences at the first time point (t1) followed by a common assessment at the second time point (t2) and the strengths of this framework for st ...
DOI:
10.1016/j.beproc.2019.04.005
PubMed:
31054948
PubMed Central:
PMC6744834

48. Behavioral toxicity of tannery effluent in zebrafish (Danio rerio) used as model system

Author:
Thales Quintão Chagas; Tenilce Gabriela da Silva Alvarez; Mateus Flores Montalvão; Carlos Mesak; Thiago Lopes Rocha; Amanda Pereira da Costa Araújo; Guilherme Malafaia
Source:
Science of the total environment 2019 v.685 pp. 923-933
ISSN:
0048-9697
Subject:
Danio rerio; Oreochromis niloticus; Poecilia; adults; animal models; animals; antipredatory behavior; behavior change; bioaccumulation; chromium; chronic exposure; ecotoxicology; fish behavior; magnesium; neurotoxicity; pollution; sodium; tannery effluents; tranquilizers
Abstract:
... The ecotoxicity of untreated tannery effluent (UTE) in several animal models has been reported; however, its effects on fish behavior, and neurotoxicity, remain unknown. Thus, the hypothesis that the chronic exposure to UTE can induce behavioral changes in adult zebrafish (Danio rerio) representatives, even when it is highly diluted in water, was tested. Animals exposed to 0.1% and 0.3% UTE for 30 ...
DOI:
10.1016/j.scitotenv.2019.06.253

49. Behavioral, molecular and physiological responses of embryo-larval zebrafish exposed to types I and II pyrethroids

Author:
Olushola M. Awoyemi; Naveen Kumar; Cassandra Schmitt; Seenivasan Subbiah; Jordan Crago
Source:
Chemosphere 2019 v.219 pp. 526-537
ISSN:
0045-6535
Subject:
Danio rerio; aquatic organisms; bifenthrin; deltamethrin; edema; embryo (animal); esfenvalerate; esterases; fenvalerate; lambda-cyhalothrin; larvae; messenger RNA; neurotoxins; nontarget organisms; pericardium; permethrin; physiological response; pyrethrins; reactive oxygen species; swimming; toxicity
Abstract:
... Pyrethroids are potent neurotoxicants that may elicit multiple pathways of toxicity in non-target organisms. Comparative studies on the mechanistic and developmental effects of types I and II pyrethroids against non-target aquatic species are limited. This study assessed the effects of the two pyrethroid types against embryo-larval zebrafish (Danio rerio) at environmentally relevant and laboratory ...
DOI:
10.1016/j.chemosphere.2018.12.026

50. Bimodal Visualization of Endogenous Nitric Oxide in Lysosomes with a Two-Photon Iridium(III) Phosphorescent Probe

Author:
Weijun Wu; Ruilin Guan; Xinxing Liao; Xu Yan; Thomas W. Rees; Liangnian Ji; Hui Chao
Source:
Analytical chemistry 2019 v.91 no.15 pp. 10266-10272
ISSN:
1520-6882
Subject:
Danio rerio; animal models; autophagy; image analysis; inflammation; iridium; lysosomes; macrophages; moieties; morpholine; nitric oxide; pH; phosphorescence; photostability
Abstract:
... Nitric oxide (NO) is a fundamental signaling molecule that shows complex effects on the catabolic autophagy process, which is closely linked with lysosomal function. In this study, a new lysosome-targeted, pH-independent, and two-photon phosphorescent iridium(III) complex, Ir-BPDA, has been investigated for endogenous NO detection and imaging. The rational design of the probe, as the addition of t ...
DOI:
10.1021/acs.analchem.9b02415

51. Binding and potential antibiofilm activities of Amaranthus proteins against Candida albicans

Author:
Rajamohamed Beema Shafreen; Siddharthan Seema; Alma Leticia Martinez-Ayala; María A Lozano-Grande; Maribel Robles-Sánchez; Arkadiusz Szterk; Michael Grishko; Ezra Hanuka; Elena Katrich; Shela Gorinstein
Source:
Colloids and surfaces 2019 v.183 pp. 110479
ISSN:
0927-7765
Subject:
Amaranthus hypochondriacus; Araneae; Candida albicans; Danio rerio; Fourier transform infrared spectroscopy; antidepressants; antifungal properties; antioxidant activity; biofilm; biopolymers; denaturation; diet; differential scanning calorimetry; edible films; embryo (animal); fluorescence; fluorescence emission spectroscopy; human serum albumin; hyphae; patients; protein isolates; therapeutics; thermal stability; urea; virulence; yeasts
Abstract:
... In the present study evaluation of structural, thermal and antifungal properties of Amaranthus hypochondriacus laboratory protein isolate (ALMA) and commercially available Amaranthus protein dietary antidepressant (APGM) was done by differential scanning calorimetry (DSC), Fourier Transform Infrared (FTIR) and fluorescence spectroscopy and antibiofilm activities against Candida albicans. The resul ...
DOI:
10.1016/j.colsurfb.2019.110479

52. Bioassay system for the detection of aryl hydrocarbon receptor agonists in waterborne pesticides using zebrafish cyp1a1 promoter-luciferase recombinant hepatic cells

Author:
Yixi Zhou; Chao Shen; Hong Du; Yuanyuan Bao; Chengyong He; Chonggang Wang; Zhenghong Zuo
Source:
Chemosphere 2019 v.220 pp. 61-68
ISSN:
0045-6535
Subject:
Danio rerio; agonists; aquatic animals; aquatic environment; bioassays; detection limit; gene expression; human cell lines; luciferase; mepanipyrim; messenger RNA; models; pencycuron; plasmids; quinoxyfen; risk assessment; surface water; tetrachlorodibenzo-p-dioxin
Abstract:
... Currently used pesticides are widely distributed in surface water. Most of them are harmful to aquatic animals. In the present study, a novel recombinant hepatic cell line was developed for detecting the activity of aryl hydrocarbon receptor (AhR) agonists, and their potential bio-toxicity to aquatic animals was evaluated. First, HepG2 cells were stably transfected with a luciferase reporter plasm ...
DOI:
10.1016/j.chemosphere.2018.12.115

53. Bioassay-guided isolation of anti-seizure principles from Semen Pharbitidis using a zebrafish pentylenetetrazol seizure model

Author:
Maoxuan Liu; Daniëlle Copmans; Jing-Guang Lu; Ming-Rong Yang; Jo Sourbron; Annelii Ny; Zhi-Hong Jiang; Peter A.M. de Witte; Walter Luyten
Source:
Journal of ethnopharmacology 2019 v.232 pp. 130-134
ISSN:
0378-8741
Subject:
Danio rerio; Ipomoea nil; active ingredients; epilepsy; ethanol; glucosides; helminthiasis; mass spectrometry; medicinal plants; models; seeds; traditional medicine
Abstract:
... Semen Pharbitidis, the seeds of Pharbitis nil (Linn.) Choisy (Convolvulaceae) is a well-known traditional Chinese medicinal plant used for treating helminthiasis and epilepsy in China.This study aims to identify the anti-seizure components from Semen Pharbitidis.A bioassay-guided isolation of anti-seizure compounds from Semen Pharbitidis was performed using a zebrafish pentylenetetrazol seizure mo ...
DOI:
10.1016/j.jep.2018.12.024

54. Bioconcentration and Metabolic Effects of Emerging PFOS Alternatives in Developing Zebrafish

Author:
Wenqing Tu; Rubén Martínez; Laia Navarro-Martin; Daniel J. Kostyniuk; Christine Hum; Jing Huang; Mi Deng; Yuanxiang Jin; Hing Man Chan; Jan Alexander Mennigen
Source:
Environmental science & technology 2019 v.53 no.22 pp. 13427-13439
ISSN:
1520-5851
Subject:
Danio rerio; energy expenditure; environmental science; feed intake; glucokinase; markets; sodium; sulfonates; transcription (genetics); wildlife
Abstract:
... The novel PFOS alternatives, 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) and sodium p-perfluorous nonenoxybenzenesulfonate (OBS), are emerging in the Chinese market, but little is known about their ecological risks. In this study, zebrafish embryos were exposed to PFOS, F-53B, and OBS to evaluate their bioconcentration and acute metabolic consequences. Per- and polyfluoroalkyl substanc ...
DOI:
10.1021/acs.est.9b03820

55. Bioconcentration and tissue distribution of shorter and longer chain perfluoroalkyl acids (PFAAs) in zebrafish (Danio rerio): Effects of perfluorinated carbon chain length and zebrafish protein content

Author:
Wu Wen; Xinghui Xia; Dong Zhou; Haotian Wang; Yawei Zhai; Hui Lin; Jian Chen; Diexuan Hu
Source:
Environmental pollution 2019 v.249 pp. 277-285
ISSN:
0269-7491
Subject:
Danio rerio; aquatic animals; bioaccumulation factor; blood; blood-brain barrier; brain; liver; muscles; perfluoroalkyl acids; perfluorocarbons; pollutants; protein content; tissue distribution; tissues
Abstract:
... Perfluoroalkyl acids (PFAAs) are a class of emerging pollutants. However, the bioconcentration and tissue distribution of shorter chain PFAAs in aquatic animals are not well understood. Here, we investigated the effects of perfluorinated carbon chain length of PFAAs and protein content of tissues on the bioconcentration and tissue distribution of both shorter chain PFAAs (linear C-F = 3–6) and lon ...
DOI:
10.1016/j.envpol.2019.03.003

56. Biological effects of the benzotriazole ultraviolet stabilizers UV-234 and UV-320 in early-staged zebrafish (Danio rerio)

Author:
Xuefang Liang; Ondrej Adamovsky; Christopher L. Souders; Christopher J. Martyniuk
Source:
Environmental pollution 2019 v.245 pp. 272-281
ISSN:
0269-7491
Subject:
Danio rerio; aquatic ecosystems; bioaccumulation; developmental toxicity; embryo (animal); embryogenesis; energy metabolism; fish; gene expression regulation; hatching; immune system; interleukin-8; larvae; locomotion; mechanism of action; messenger RNA; mitochondria; risk; stabilizers; triazoles
Abstract:
... Among the benzotriazole ultraviolet stabilizers (BUVSs), UV-234 and UV-320 are frequently detected in aquatic ecosystem. Despite the fact that these chemicals are present in low ng/L levels in surface water, they show high bio-accumulation potential and pose exposure risks to aquatic organisms. However, there are limited toxicological data available in fish. In this study, zebrafish embryos were e ...
DOI:
10.1016/j.envpol.2018.10.130

57. Biological evaluation of microbial toxin degradation by microinjected zebrafish (Danio rerio) embryos

Author:
Zsolt Csenki; Edina Garai; Anita Risa; Mátyás Cserháti; Katalin Bakos; Dalma Márton; Zoltán Bokor; Balázs Kriszt; Béla Urbányi
Source:
Chemosphere 2019 v.227 pp. 151-161
ISSN:
0045-6535
Subject:
Cupriavidus basilensis; Danio rerio; death; droplet size; eggs; embryo (animal); embryonic mortality; guidelines; metabolites; microorganisms; mortality; ochratoxin A; toxicity
Abstract:
... The use of microinjection of newly fertilized zebrafish eggs as an appropriate tool for qualifying the biodetoxification properties of toxin-degrading microbes was investigated. Ochratoxin A (OTA), bacterial degradation products of OTA and bacterial metabolites of the Cupriavidus basilensis ŐR16 strain were microinjected. Results showed that variations in the injected droplet size, and thus treatm ...
DOI:
10.1016/j.chemosphere.2019.04.014

58. Biologically safe colloidal suspensions of naked iron oxide nanoparticles for in situ antibiotic suppression

Author:
Massimiliano Magro; Davide Baratella; Simone Molinari; Andrea Venerando; Gabriella Salviulo; Giulia Chemello; Ike Olivotto; Giorgio Zoppellaro; Juri Ugolotti; Claudia Aparicio; Jiri Tucek; Anna P. Fifi; Giuseppe Radaelli; Radek Zboril; Fabio Vianello
Source:
Colloids and surfaces 2019 v.181 pp. 102-111
ISSN:
0927-7765
Subject:
Danio rerio; Escherichia coli; animal models; antibacterial properties; bacteria; colloidal properties; colloids; drugs; ferric oxide; ligands; maghemite; magnetism; nanoparticles; oxytetracycline; remediation; tanks; toxicity
Abstract:
... A category of naked maghemite nanoparticles (γ-Fe₂O₃), named surface active maghemite nanoparticles (SAMNs), is characterized by biological safety, high water colloidal stability and a surface chemistry permitting the binding of ligands. In the present study, the interaction between SAMNs and an antibiotic displaying chelating properties (oxytetracycline, OxyTC) was extensively structurally and ma ...
DOI:
10.1016/j.colsurfb.2019.05.036

59. Biomaterial substrate-derived compact cellular spheroids mimicking the behavior of pancreatic cancer and microenvironment

Author:
Chui-Wei Wong; Hao-Wei Han; Yu-Wen Tien; Shan-hui Hsu
Source:
Biomaterials 2019 v.213 pp. 119202
ISSN:
0142-9612
Subject:
Danio rerio; adenocarcinoma; biocompatible materials; cell structures; chitosan; coculture; drugs; humans; hyaluronic acid; metastasis; models; neoplasm cells; pancreatic neoplasms; patients; phenotype; prognosis; screening; stromal cells; therapeutics
Abstract:
... Pancreatic stromal cells especially pancreatic stellate cells (PSCs) play a critical role in the progression of human pancreatic ductal adenocarcinoma (PDAC). However, the exact interaction between cancer cells and PSCs remains to be elucidated in order to develop more effective therapeutic approaches to treat PDAC. The microenvironment of PDAC shows higher hyaluronan (HA) levels, which is associa ...
DOI:
10.1016/j.biomaterials.2019.05.013

60. Biomimetic Accumulation of Methamphetamine and Its Metabolite Amphetamine by Diffusive Gradients in Thin Films to Estimate Their Bioavailability in Zebrafish

Author:
Xingxing Yin; Changsheng Guo; Jiapei Lv; Song Hou; Yan Zhang; Xiaowei Jin; Yanguo Teng; Jian Xu
Source:
Environmental science & technology letters 2019 v.6 no.12 pp. 708-713
ISSN:
2328-8930
Subject:
Danio rerio; amphetamine; bioaccumulation; bioavailability; biomimetics; biotransformation; films (materials); fish; metabolites; methamphetamines
Abstract:
... In this study, we evaluated the application of the diffusive gradient in the thin films (DGT) technique to predict the bioavailability of methamphetamine (METH) and its metabolite, amphetamine (AMP), in zebrafish (Danio rerio). We simultaneously exposed zebrafish and DGT devices to water spiked with different concentrations of METH. Subsequently, METH and its major metabolite, AMP, were quantified ...
DOI:
10.1021/acs.estlett.9b00669

61. Biotechnological potential of a cysteine protease (CpCP3) from Calotropis procera latex for cheesemaking

Author:
Maria Z.R. Silva; João P.B. Oliveira; Márcio V. Ramos; Davi F. Farias; Chayenne A. de Sá; Juliana A.C. Ribeiro; Ayrles F.B. Silva; Jeanlex S. de Sousa; Rafael A. Zambelli; Ana C. da Silva; Gilvan P. Furtado; Thalles B. Grangeiro; Mirele S. Vasconcelos; Sandro R. Silveira; Cleverson D.T. Freitas
Source:
Food chemistry 2019 pp. -
ISSN:
0308-8146
Subject:
Calotropis procera; Danio rerio; Escherichia coli; allergenicity; atomic force microscopy; cattle; cheesemaking; cheeses; chymosin; cysteine proteinases; embryo (animal); kappa-casein; latex; metal ions; micelles; peptides; sensory evaluation; water content
Abstract:
... This article reports the characterization and evaluation of the biotechnological potential of a cysteine protease purified from Calotropis procera (CpCP3). This enzyme was highly stable to different metal ions and was able to hydrolyze κ-casein similarly to bovine chymosin. Atomic force microscopy showed that the process of casein micelle aggregation induced by CpCP3 was similar to that caused by ...
DOI:
10.1016/j.foodchem.2019.125574

62. Bisphenol F-Induced Neurotoxicity toward Zebrafish Embryos

Author:
Lilai Yuan; Le Qian; Yu Qian; Jia Liu; Ke Yang; Ying Huang; Chengju Wang; Yingren Li; Xiyan Mu
Source:
Environmental science & technology 2019 v.53 no.24 pp. 14638-14648
ISSN:
1520-5851
Subject:
Danio rerio; acetylcholine; acetylcholinesterase; apoptosis; astrocytes; bisphenol F; brain; chromatin immunoprecipitation; developmental stages; dopamine; environmental science; enzyme activity; fluorescent antibody technique; locomotion; motor neurons; neurotoxicity; neurotransmitters; phenotype; sequence analysis; serotonin; synaptic transmission; technology; transcription (genetics)
Abstract:
... In this study, the influence of bisphenol F (BPF) toward central nervous system (CNS) was assessed using zebrafish embryos. We found that BPF could induce significant neurotoxicity toward zebrafish embryos, including inhibited locomotion, reduced moving distance, and CNS cell apoptosis at an effective concentration of 0.0005 mg/L. Immunofluorescence assay showed that both microglia and astrocyte i ...
DOI:
10.1021/acs.est.9b04097

63. Bitter gourd (Momordica charantia) possess developmental toxicity as revealed by screening the seeds and fruit extracts in zebrafish embryos

Author:
Muhammad Farooq Khan; Nael Abutaha; Fahd A. Nasr; Ali S. Alqahtani; Omar M. Noman; Mohammad A. M. Wadaan
Source:
BMC complementary and alternative medicine 2019 v.19 no.1 pp. 184
ISSN:
1472-6882
Subject:
Danio rerio; Fourier transform infrared spectroscopy; Momordica charantia; alternative medicine; cardiotoxicity; chemical composition; death; embryo (animal); fetus; fractionation; fruit extracts; fruits; gas chromatography; heart; high performance liquid chromatography; hypertrophy; in vivo studies; lethal dose 50; mass spectrometry; myoblasts; patients; risk; screening; seed extracts; seeds; teratogenicity
Abstract:
... BACKGROUND: Bitter gourd (Momordica charantia) has attracted the focus of researchers owing to its excellent anti-diabetic action. The beneficial effect of Momordica charantia on heart has been reported by in vitro and in vivo studies. However the developmental toxicity or potential risk of M. charantia on fetus heart development is largely unknown. Hence this study was designed to find out the de ...
DOI:
10.1186/s12906-019-2599-0
PubMed:
31340810
PubMed Central:
PMC6657154

64. Black Raspberry (Rubus coreanus Miquel) Promotes Browning of Preadipocytes and Inguinal White Adipose Tissue in Cold-Induced Mice

Author:
Woo Yong Park; Seong-Kyu Choe; Jinbong Park; Jae-Young Um
Source:
Nutrients 2019 v.11 no.9 pp. -
ISSN:
2072-6643
Subject:
Danio rerio; Rubus coreanus; Rubus occidentalis; active ingredients; adipocytes; ellagic acid; heat production; humans; lipids; mesenchymal stromal cells; mice; models; obesity; oral administration; peroxisome proliferator-activated receptor gamma; temperature; white adipose tissue; zinc finger motif
Abstract:
... The alteration of white adipose tissue (WAT) “browning”, a change of white into beige fat, has been considered as a new therapeutic strategy to treat obesity. In this study, we investigated the browning effect of black raspberry (Rubus coreanus Miquel) using in vitro and in vivo models. Black raspberry water extract (BRWE) treatment inhibited lipid accumulation in human mesenchymal ste ...
DOI:
10.3390/nu11092164
PubMed:
31509935
PubMed Central:
PMC6769844

65. Blood flow-mediated gene transfer and siRNA-knockdown in the developing vasculature in a spatio-temporally controlled manner in chicken embryos

Author:
Yuta Takase; Yoshiko Takahashi
Source:
Developmental biology 2019 v.456 no.1 pp. 8-16
ISSN:
0012-1606
Subject:
DNA; Danio rerio; abnormal development; aorta; blood; blood flow; chick embryos; genes; heart; lipid content; lipids; mice; small interfering RNA; transfection; transgenesis
Abstract:
... We describe a method by which early developing vasculature can be gene-manipulated independently of the heart in a spatio-temporally controlled manner. Lipofectamine 2000 or 3000, an easy-to-use lipid reagent, has been found to yield a high efficiency of transfection when co-injected with GFP DNA within a critical range of lipid concentration. By exploiting developmentally changing patterns of vas ...
DOI:
10.1016/j.ydbio.2019.08.001

66. Butylated Hydroxyanisole Exerts Neurotoxic Effects by Promoting Cytosolic Calcium Accumulation and Endoplasmic Reticulum Stress in Astrocytes

Author:
Sunwoo Park; Jin-Young Lee; Whasun Lim; Seungkwon You; Gwonhwa Song
Source:
Journal of agricultural and food chemistry 2019 v.67 no.34 pp. 9618-9629
ISSN:
1520-5118
Subject:
Danio rerio; animal models; antioxidants; astrocytes; biomarkers; brain; butylated hydroxyanisole; calcium; caspase-3; caspase-9; cell cycle checkpoints; chelating agents; cytochrome c; cytotoxicity; embryo (animal); endoplasmic reticulum stress; genetically modified organisms; hepatotoxicity; humans; in vivo studies; inflammation; learning; mitogen-activated protein kinase; nerve tissue; neurotoxicity; non-specific serine/threonine protein kinase; nutritional support; phosphatidylinositol 3-kinase; pro-apoptotic proteins; protein synthesis; regulatory proteins; signal transduction; sleep
Abstract:
... Astrocytes provide nutritional support, regulate inflammation, and perform synaptic functions in the human brain. Although butylated hydroxyanisole (BHA) is a well-known antioxidant, several studies in animals have indicated BHA-mediated liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. However, the specific effects of BHA on human astrocytes and the un ...
DOI:
10.1021/acs.jafc.9b02899

67. CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications

Author:
Felix Schmöhl; Verena Peters; Claus Peter Schmitt; Gernot Poschet; Michael Büttner; Xiaogang Li; Tim Weigand; Tanja Poth; Nadine Volk; Jakob Morgenstern; Thomas Fleming; Peter P. Nawroth; Jens Kroll
Source:
Cellular and molecular life sciences 2019 v.76 no.22 pp. 4551-4568
ISSN:
1420-682X
Subject:
Danio rerio; amino acid composition; amino acid metabolism; amino acids; biochemical pathways; carnosine; diabetic nephropathy; enzymes; genes; kidneys; overfeeding; weight gain
Abstract:
... The gene CNDP1 was associated with the development of diabetic nephropathy. Its enzyme carnosinase 1 (CN1) primarily hydrolyzes the histidine-containing dipeptide carnosine but other organ and metabolic functions are mainly unknown. In our study we generated CNDP1 knockout zebrafish, which showed strongly decreased CN1 activity and increased intracellular carnosine levels. Vasculature and kidneys ...
DOI:
10.1007/s00018-019-03127-z

68. CO release with ratiometric fluorescence changes: a promising visible-light-triggered metal-free CO-releasing molecule

Author:
Weiyong Feng; Shumin Feng; Guoqiang Feng
Source:
Chemical communications 2019 v.55 no.61 pp. 8987-8990
ISSN:
1364-548X
Subject:
Danio rerio; aqueous solutions; chemical compounds; chemical reactions; fluorescence; mice
Abstract:
... The first visible-light-triggered metal-free and ratiometric fluorescent CORM is reported. This CORM can be used to release CO with distinct ratiometric fluorescence changes in aqueous solution, living cells, zebrafish, and mice, which provided an excellent controllable and trackable CORM for living systems. ...
DOI:
10.1039/c9cc04026a

69. Can dietary ginger (Zingiber officinale) alter biochemical and immunological parameters and gene expression related to growth, immunity and antioxidant system in zebrafish (Danio rerio)?

Author:
Ehsan Ahmadifar; Najmeh Sheikhzadeh; Kambiz Roshanaei; Narges Dargahi; Caterina Faggio
Source:
Aquaculture 2019 v.507 pp. 341-348
ISSN:
0044-8486
Subject:
Danio rerio; Zingiber officinale; amylases; animal growth; antioxidants; catalase; complement; enzyme activity; fish; gene expression; gene expression regulation; genes; ghrelin; ginger; immune system; immunity; immunoglobulins; lysozyme
Abstract:
... Effects of the dietary ginger (Zingiber officinale) on growth, some immunological and biochemical parameters and gene expression related to growth, immunity and antioxidant systems in zebrafish were studied. Immune parameters such as immunoglobulin level, alternative complement activity, and lysozyme activity were significantly higher in treatment groups fed with 2% and 3% ginger than the control ...
DOI:
10.1016/j.aquaculture.2019.04.049

70. Cancer-associated fibroblast regulate proliferation and migration of prostate cancer cells through TGF-β signaling pathway

Author:
Dai-Yu Sun; Jia-Qi Wu; Zhi-Heng He; Ming-Fang He; Hong-Bin Sun
Source:
Life sciences 2019 pp. -
ISSN:
0024-3205
Subject:
Danio rerio; animal models; cell lines; cell proliferation; culture media; fibroblasts; in vitro studies; neoplasm cells; neoplasm progression; patients; prostatic neoplasms; signal transduction; transforming growth factor beta 1; transforming growth factor beta receptors
Abstract:
... Prostate cancer (PCa) incidence rates are rising in China currently. Cancer-associated fibroblasts (CAFs), as a major component of tumor microenvironment, are crucial for tumor progression. This study was aimed to explore the promotion effect of patient-derived CAFs on the proliferation and migration of prostate cancer cells.CAFs were isolated from tumor tissues of PCa patients. The promotion effe ...
DOI:
10.1016/j.lfs.2019.116791

71. Capillary zone electrophoresis-tandem mass spectrometry with ultraviolet photodissociation (213 nm) for large-scale top–down proteomics

Author:
Elijah N. McCool; Daoyang Chen; Wenxue Li; Yansheng Liu; Liangliang Sun
Source:
Analytical methods 2019 v.11 no.22 pp. 2855-2861
ISSN:
1759-9679
Subject:
Danio rerio; acetylation; brain; calmodulin; data collection; fractionation; gases; gel chromatography; molecular weight; myristoylation; photolysis; photons; post-translational modification; proteomics; tandem mass spectrometry
Abstract:
... Capillary zone electrophoresis-tandem mass spectrometry (CZE-MS/MS) has attracted attention recently for large-scale top–down proteomics that aims to characterize proteoforms in cells at a global scale with high throughput. In this work, CZE-MS/MS with ultraviolet photodissociation (UVPD) was evaluated for large-scale top–down proteomics for the first time. Roughly, 600 proteoforms and 369 protein ...
DOI:
10.1039/c9ay00585d
PubMed:
31608127
PubMed Central:
PMC6788745

72. Cardiotoxicity of forchlorfenuron (CPPU) in zebrafish (Danio rerio) and H9c2 cardiomyocytes

Author:
Guiyi Gong; Hiotong Kam; Yuchung Tse; Simon Mingyuen Lee
Source:
Chemosphere 2019 v.235 pp. 153-162
ISSN:
0045-6535
Subject:
Danio rerio; GATA transcription factors; cardiomyocytes; cardiotoxicity; cytoskeleton; cytotoxicity; deformation; ecosystems; erythrocytes; farmers; forchlorfenuron; fruit quality; gene expression; herbicides; messenger RNA; models; plant growth substances; risk; watermelons
Abstract:
... Forchlorfenuron (CPPU), as a plant growth regulator or herbicide/pesticide, is widely used in agriculture worldwide. It is adopted by most farmers due to its high efficacy for boosting size and improving the quality of fruit. However, CPPU was implicated in, and gained notoriety due to an incident of exploding watermelon that occurred in 2011. Subsequently, the wider community became aware of the ...
DOI:
10.1016/j.chemosphere.2019.06.027

73. Caspase-Dependent Apoptosis in Prostate Cancer Cells and Zebrafish by Corchorusoside C from Streptocaulon juventas

Author:
Gerardo D. Anaya-Eugenio; Ermias Mekuria Addo; Nathan Ezzone; Joshua M. Henkin; Tran Ngoc Ninh; Yulin Ren; Djaja D. Soejarto; A. Douglas Kinghorn; Esperanza J. Carcache de Blanco
Source:
Journal of natural products 2019 v.82 no.6 pp. 1645-1655
ISSN:
1520-6025
Subject:
Danio rerio; antineoplastic agents; apoptosis; caspases; cell lines; colon; cytotoxicity; dose response; inhibitory concentration 50; intercellular adhesion molecule-1; models; neoplasm cells; population growth; prostatic neoplasms; protein content; protein synthesis; shrinkage; transcription factor NF-kappa B; Vietnam
Abstract:
... Corchorusoside C (1), isolated from Streptocaulon juventas collected in Vietnam, was found to be nontoxic in a zebrafish (Danio rerio) model and to induce cytotoxicity in several cancer cell lines with notable selective activity against prostate DU-145 cancer cells (IC₅₀ 0.08 μM). Moreover, corchorusoside C induced DU-145 cell shrinkage and cell detachment. In CCD-112CoN colon normal cells, 1 show ...
DOI:
10.1021/acs.jnatprod.9b00140
PubMed:
31120251
PubMed Central:
PMC6615048

74. Cationic cyanine chromophore-assembled upconversion nanoparticles for sensing and imaging H2S in living cells and zebrafish

Author:
Fangfang Wang; Cuiling Zhang; Xuetong Qu; Shasha Cheng; Yuezhong Xian
Source:
Biosensors & bioelectronics 2019 v.126 pp. 96-101
ISSN:
0956-5663
Subject:
Danio rerio; biosensors; cytotoxicity; hydrogen sulfide; image analysis; light intensity; monitoring; nanoparticles; polyacrylic acid
Abstract:
... Elevated hydrogen sulfide (H₂S) level is closely associated with various diseases. So the sensing of H₂S is noteworthy for divulging its role in diagnosing these diseases. Herein, we proposed poly(acrylic acid)-modified upconversion nanoparticles assembled with cationic near-infrared cyanine chromophores (Cy7-Cl) as the nanoprobe (Cy7-UCNPs) for monitoring H₂S based on thiolation reactions. The pr ...
DOI:
10.1016/j.bios.2018.10.056

75. Cell Type Purification by Single-Cell Transcriptome-Trained Sorting

Author:
Chloé S. Baron; Aditya Barve; Mauro J. Muraro; Reinier van der Linden; Gitanjali Dharmadhikari; Anna Lyubimova; Eelco J.P. de Koning; Alexander van Oudenaarden
Source:
Cell 2019 v.179 no.2 pp. 527-542.e19
ISSN:
0092-8674
Subject:
Danio rerio; antibodies; flow cytometry; fluorescence; genetic engineering; human cell lines; kidneys; labor; mitochondria; pancreas; transcriptomics; transgenes
Abstract:
... Much of current molecular and cell biology research relies on the ability to purify cell types by fluorescence-activated cell sorting (FACS). FACS typically relies on the ability to label cell types of interest with antibodies or fluorescent transgenic constructs. However, antibody availability is often limited, and genetic manipulation is labor intensive or impossible in the case of primary human ...
DOI:
10.1016/j.cell.2019.08.006
PubMed:
31585086
PubMed Central:
PMC6863042

76. Characterisation of amphioxus protein kinase C-δ/θ reveals a unique proto-V3 domain suggesting an evolutionary mechanism for PKC-θ unique V3

Author:
Zhi-long Chen; Bei-Ni Gong; Qi-long Wang; Zhi-hui Xiao; Chong Deng; Wen-qian Wang; Yingqiu Li
Source:
Fish & shellfish immunology 2019 v.84 pp. 1100-1107
ISSN:
1050-4648
Subject:
Danio rerio; Drosophila; Homo sapiens; T-lymphocytes; adaptive immunity; ancestry; fish; immunological synapse; mammals; models; phylogeny; protein kinase C; shellfish; transcription factor NF-kappa B
Abstract:
... A primitive adaptive immune system has recently been suggested to be present in a basal chordate amphioxus (Branchiostoma belcheri, Bb), making it an ideal model for studying the origin of adaptive immune. The novel protein kinase C isoform PKC-θ, but not its closest isoform PKC-δ, plays a critical role for mammalian T-cell activation via translocation to immunological synapse (IS) mediated by a u ...
DOI:
10.1016/j.fsi.2018.11.001

77. Characterization and Application of Lignin–Carbohydrate Complexes from Lignocellulosic Materials as Antioxidants for Scavenging In Vitro and In Vivo Reactive Oxygen Species

Author:
Huiling Dong; Liming Zheng; Pengjun Yu; Qing Jiang; Yan Wu; Caoxing Huang; Baishuang Yin
Source:
ACS sustainable chemistry & engineering 2019 v.8 no.1 pp. 256-266
ISSN:
2168-0485
Subject:
Danio rerio; Populus; animal models; antioxidant activity; antioxidant enzymes; bamboos; enzyme activity; free radicals; glutathione peroxidase; lignin; lignocellulose; metabolism; nuclear magnetic resonance spectroscopy; oxidative stress; oxygen; reactive oxygen species; superoxide dismutase
Abstract:
... Lignin–carbohydrate complexes (LCCs) have shown antioxidant ability to scavenge the individual free radicals in vitro, while little work has been carried out to show if the LCCs can efficiently scavenge the intracellular and endogenous reactive oxygen species (ROS), which are the multiple radicals derived from the reduction of molecular oxygen during the metabolism process. In this work, carbohydr ...
DOI:
10.1021/acssuschemeng.9b05290

78. Characterization and kinetic study of the brain and muscle acetylcholinesterase from Danio rerio

Author:
Claudiane S. Marinho; Marcos V.F. Matias; Iago G.F. Brandão; Elton L. Santos; Sonia S. Machado; Carmem L.P.S. Zanta
Source:
Comparative biochemistry and physiology 2019 v.222 pp. 11-18
ISSN:
1532-0456
Subject:
Danio rerio; acetylcholinesterase; brain; enzyme kinetics; inhibitory concentration 50; muscles; organophosphorus compounds; physostigmine; temperature
Abstract:
... Acetylcholinesterase (AChE) plays an important role in the therapy of Alzheimer's disease and in the detection of pesticides such as organophosphates which are also widely used in chemical warfare. The aim of this study is the physicochemical and kinetic characterization of brain and muscle ChE from Danio rerio (Zebrafish). Optimal activity was found for brain ChE at alkaline pH 9.0 at 30 °C, and ...
DOI:
10.1016/j.cbpc.2019.04.005

79. Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos

Author:
Jeffrey J. Kelu; Sarah E. Webb; Antony Galione; Andrew L. Miller
Source:
Developmental biology 2019 v.445 no.2 pp. 211-225
ISSN:
0012-1606
Subject:
Danio rerio; Golgi apparatus; N-glycoside hydrolases; adenine; calcium; calcium signaling; cell culture; cell differentiation; embryo (animal); messenger RNA; molecular cloning; muscle development; niacin; nicotinamide; phosphates; plasma membrane; sarcoplasmic reticulum
Abstract:
... We recently demonstrated the requirement of two-pore channel type 2 (TPC2)-mediated Ca2+ release during slow muscle cell differentiation and motor circuit maturation in intact zebrafish embryos. However, the upstream trigger(s) of TPC2/Ca2+ signaling during these developmental processes remains unclear. Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+ mobilizing messenger, wh ...
DOI:
10.1016/j.ydbio.2018.11.005
PubMed:
30447180
PubMed Central:
PMC6675606

80. Characterization of functionalized multiwalled carbon nanotubes and comparison of their cellular toxicity between HEK 293 cells and zebra fish in vivo.

Author:
Ayush Chowdhry; Jasreen Kaur; Madhu Khatri; Veena Puri; Rakesh Tuli; Sanjeev Puri
Source:
Heliyon 2019 v.5 no.10 pp. e02605
ISSN:
2405-8440
Subject:
Danio rerio; Fourier transform infrared spectroscopy; carbon nanotubes; chemical bonding; cytotoxicity; energy-dispersive X-ray analysis; oxidative stress; solubilization
Abstract:
... Carbon nanotubes (CNTs) hold tremendous potential due to their unique and modifiable properties. Their robust biological applications necessitate minimizing their cytotoxicity and increasing the solubilization. In the present manuscript, we have functionalized multiwalled carbon nanotubes (MWCNTs) using defect functionalization methodology to covalently bind carboxy and amino groups on their walls ...
DOI:
10.1016/j.heliyon.2019.e02605
PubMed:
31687491
PubMed Central:
PMC6820100

81. Characterization of paralogous uncx transcription factor encoding genes in zebrafish

Author:
Valeria Nittoli; Antonio Emidio Fortunato; Giulia Fasano; Ugo Coppola; Alessandra Gentile; Sylvie Maiella; Fernanda Langellotto; Immacolata Porreca; Raffaella De Paolo; Rita Marino; Marcella Fiengo; Aldo Donizetti; Francesco Aniello; Takashi Kondo; Filomena Ristoratore; Lorella M.T. Canzoniero; Denis Duboule; Stephen W. Wilson; Paolo Sordino
Source:
Gene 2019 v.721 pp. 100011
ISSN:
0378-1119
Subject:
Danio rerio; embryogenesis; genes; genomics; innervation; mice; nucleic acid hybridization; transcription factors
Abstract:
... The paired-type homeodomain transcription factor Uncx is involved in multiple processes of embryogenesis in vertebrates. Reasoning that zebrafish genes uncx4.1 and uncx are orthologs of mouse Uncx, we studied their genomic environment and developmental expression. Evolutionary analyses indicate the zebrafish uncx genes as being paralogs deriving from teleost-specific whole-genome duplication. Whol ...
DOI:
10.1016/j.gene.2019.100011

82. Chemical constituents of leaves of Persea americana (avocado) and their protective effects against neomycin-induced hair cell damage

Author:
SeonJu Park; Youn Hee Nam; Isabel Rodriguez; Jun Hyung Park; Hee Jae Kwak; Youngse Oh; Mira Oh; Min Seon Park; Kye Wan Lee; Jung Suk Lee; Do Hoon Kim; Yu Hwa Park; In Seok Moon; Se-Young Choung; Kwang Won Jeong; Bin Na Hong; Tong Ho Kang; Seung Hyun Kim
Source:
Revista Brasileira de Farmacognosia 2019 v.29 no.6 pp. 739-743
ISSN:
0102-695X
Subject:
Danio rerio; Persea americana; avocados; cell lines; cell viability; chemical composition; cytotoxicity; fish larvae; flavonols; glycosides; leaves; lignans; magnetism; mass spectrometry; mice; protective effect; subtropics
Abstract:
... Persea americana Mill., Lauraceae, commonly known as the avocado, is native to tropical and subtropical regions, including Brazil. From the leaves of P. americana, one previously undescribed flavonol glycoside (1) together with ten known flavonoids (2–11), four megastigmane glycosides (12–15) and two lignans (16–17) were isolated. Their structures were determined by extensive spectroscopic methods ...
DOI:
10.1016/j.bjp.2019.08.004

83. Chlorpyrifos disturbs hepatic metabolism associated with oxidative stress and gut microbiota dysbiosis in adult zebrafish

Author:
Xiaoyu Wang; Manlu Shen; Jiajie Zhou; Yuanxiang Jin
Source:
Comparative biochemistry and physiology 2019 v.216 pp. 19-28
ISSN:
1532-0456
Subject:
Danio rerio; Proteobacteria; adults; amino acid metabolism; bacteria; chlorpyrifos; dysbiosis; fish; gas chromatography; genes; glucose; glutathione; glycolysis; intestinal microorganisms; lipid metabolism; lipid metabolism disorders; liver; males; malondialdehyde; mass spectrometry; metabolites; oxidative stress; toxicity; transcription (genetics); tricarboxylic acid cycle
Abstract:
... Chlorpyrifos (CPF) is widely used in agriculture and is considered one of the most toxic pesticides to fish. In this study, adult male zebrafish were exposed to CPF at concentrations of 30, 100 and 300 μg/L for 21 days. It was observed that CPF not only induced oxidative stress but also caused gut microbiota dysbiosis in the gut. The malondialdehyde (MDA) levels increased, and the glutathione (GSH ...
DOI:
10.1016/j.cbpc.2018.11.010

84. Chronic exposure to 6:2 chlorinated polyfluorinated ether sulfonate acid (F-53B) induced hepatotoxic effects in adult zebrafish and disrupted the PPAR signaling pathway in their offspring

Author:
Guohui Shi; Qianqian Cui; Jinxing Wang; Hua Guo; Yitao Pan; Nan Sheng; Yong Guo; Jiayin Dai
Source:
Environmental pollution 2019 v.249 pp. 550-559
ISSN:
0269-7491
Subject:
Danio rerio; adults; blood; chronic exposure; females; fish; gene expression; gene ontology; genes; gonads; hepatotoxicity; industry; larvae; liver; males; parents; perfluorooctane sulfonic acid; peroxisome proliferator-activated receptors; progeny; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; sulfonates; transcription (genetics); transcriptomics; triacylglycerols; wildlife
Abstract:
... As a Chinese-specific alternative to perfluorooctane sulfonate (PFOS), 6:2 chlorinated polyfluorinated ether sulfonate (commercial name: F-53B) has been used in the metal plating industry for over 40 years. This prevalence of use has resulted in its subsequent detection within the environment, wildlife, and humans. Despite this, however, its hepatotoxic effects on aquatic organisms remain unclear. ...
DOI:
10.1016/j.envpol.2019.03.032

85. Chronic exposure to dietary selenomethionine dysregulates the genes involved in serotonergic neurotransmission and alters social and antipredator behaviours in zebrafish (Danio rerio)

Author:
Anoosha Attaran; Arash Salahinejad; Adam L. Crane; Som Niyogi; Douglas P. Chivers
Source:
Environmental pollution 2019 v.246 pp. 837-844
ISSN:
0269-7491
Subject:
Danio rerio; adults; amine oxidase (flavin-containing); antipredatory behavior; brain; chronic exposure; dietary exposure; fearfulness; fish; gene expression; gene expression regulation; genes; humans; messenger RNA; metalloids; predation; risk; selenium; selenomethionine; serotonin receptors; signal transduction; social behavior; social class; swimming; tryptophan
Abstract:
... Selenium (Se) is a metalloid of potential interest from both a toxicological and nutritional perspective, having a range of safe intake. The adverse neuro-behavioural effects of Se have been investigated in both humans and fishes, but little is known about its effects on social behaviours or the serotonergic signaling pathway in the brain. In the present study, we investigated the effects of chori ...
DOI:
10.1016/j.envpol.2018.12.090

86. Chronic exposure to environmental levels of cis-bifenthrin: Enantioselectivity and reproductive effects on zebrafish (Danio rerio)

Author:
Dandan Xiang; Linxi Zhong; Shuyuan Shen; Zhuoying Song; Guonian Zhu; Mengcen Wang; Qiangwei Wang; Bingsheng Zhou
Source:
Environmental pollution 2019 v.251 pp. 175-184
ISSN:
0269-7491
Subject:
Danio rerio; adverse effects; animal ovaries; aquatic environment; chronic exposure; enantiomers; enantioselectivity; environmental assessment; fecundity; females; fish; gametogenesis; genes; histopathology; males; nontarget organisms; pest control; pesticides; progeny; pyrethrins; risk; risk assessment; spawning; spermatozoa; testes; toxicity
Abstract:
... Synthetic pyrethroids (SPs) are broadly used to control pests and have been widely detected in aquatic environments, prompting concern over its risk to the health of non-target organisms. The present study evaluated whether long-term (60 d) exposure to low doses (0, 20, 100, and 500 ng/L) of cis-BF enantiomers (1S-cis-BF and 1R-cis-BF) could cause reproductive endocrine disturbance to zebrafish. E ...
DOI:
10.1016/j.envpol.2019.04.089

87. Circular RNAs in human and vertebrate neural retinas

Author:
Lan-Fang Sun; Bing Zhang; Xue-Jiao Chen; Xiao-Yun Wang; Bo-Wen Zhang; Yang-Yang Ji; Kun-Chao Wu; Jinyu Wu; Zi-Bing Jin
Source:
RNA biology 2019 v.16 no.6 pp. 821-829
ISSN:
1555-8584
Subject:
Danio rerio; Scandentia; brain; cell structures; chemical bonding; humans; mice; monkeys; retina; swine
Abstract:
... Circular RNAs (circRNAs) belong to an endogenous class of RNA molecules with both ends covalently linked in a circle. Although their expression pattern in the mammalian brain has been well studied, the characteristics and functions of circRNAs in retinas remain unknown. To reveal the whole expression profiles of circRNAs in the neural retina, we investigated retinal RNAs of human, monkey, mouse, p ...
DOI:
10.1080/15476286.2019.1591034
PubMed:
30874468
PubMed Central:
PMC6546369

88. Clethodim exposure induces developmental immunotoxicity and neurobehavioral dysfunction in zebrafish embryos

Author:
Guanghua Xiong; Lufang Zou; Yunyun Deng; Yunlong Meng; Xinjun Liao; Huiqiang Lu
Source:
Fish & shellfish immunology 2019 v.86 pp. 549-558
ISSN:
1050-4648
Subject:
Danio rerio; Toll-like receptor 4; acetylcholinesterase; agonists; apoptosis; aquatic ecosystems; body length; carbachol; cholinergic receptors; clethodim; dose response; edema; embryogenesis; enzyme activity; fish larvae; gene expression regulation; genes; heart rate; histones; immunotoxicity; interferon-gamma; interleukin-1beta; interleukin-8; oxidative stress; survival rate; transcription factor NF-kappa B; tumor necrosis factor-alpha; yolk sac
Abstract:
... Clethodim is one of the most widely used herbicides in agriculture, but its potential negative effects on aquatic organisms are still poorly understood. This study examined the effects of clethodim on zebrafish at aspects of early stage embryonic development, immune toxicity, cell apoptosis and locomotor behavior. Firstly, clethodim exposure markedly decreased the survival rate, body length, and h ...
DOI:
10.1016/j.fsi.2018.12.002

89. Cloning of six serpin genes and their responses to GCRV infection in grass carp (Ctenopharyngodon idella)

Author:
Liangming Chen; Rong Huang; Denghui Zhu; Yumeng Wang; Rumana Mehjabin; Yongming Li; Lanjie Liao; Libo He; Zuoyan Zhu; Yaping Wang
Source:
Fish & shellfish immunology 2019 v.86 pp. 93-100
ISSN:
1050-4648
Subject:
Ctenopharyngodon idella; Danio rerio; Reoviridae; anticoagulants; aquaculture; blood; carp; coagulation; death; gene expression; gene expression regulation; genes; homeostasis; immunology; liver; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; serine proteinase inhibitors; serpins; shellfish
Abstract:
... Grass carp, an economically important aquaculture fish, is very sensitive to Grass Carp Reovirus (GCRV). Haemorrhagic disease caused by GCRV infection can cause large-scale death of first-year grass carp, thereby severely restricting the intensive culture. Serpins (serine protease inhibitors) belong to the protease inhibitor gene family and are involved in numerous physiological and pathological p ...
DOI:
10.1016/j.fsi.2018.11.008

90. Cloning, molecular characterization, and tissue differential expression of connective tissue growth factor (ctgf) of grass carp

Author:
Wen-Qian Pan; Jun-Peng Wang; Zhi-Han Tu; Tian Gan; Jing Hu; Jing Wei; Xiang-Jun Leng; Xiao-Qin Li
Source:
Fish physiology and biochemistry 2019 v.45 no.4 pp. 1431-1443
ISSN:
0920-1742
Subject:
Astyanax mexicanus; Ctenopharyngodon idella; Cyprinus carpio; Danio rerio; Megalobrama amblycephala; adhesion; amino acids; angiogenesis; bioinformatics; blood; brain; complementary DNA; embryogenesis; extracellular matrix; fibrosis; gene expression regulation; genes; gills; heart; hydrophilicity; intestines; isoelectric point; kidneys; liver; molecular cloning; molecular weight; muscles; nucleotide sequences; polypeptides; quantitative polymerase chain reaction; rapid amplification of cDNA ends; signal peptide; skin (animal); spleen
Abstract:
... Connective tissue growth factor (ctgf) is involved in the proliferation, migration, adhesion of cell, and the constituent of extracellular matrix, which plays an important role in embryogenesis, angiogenesis, wound repair, and fibrosis diseases. In this study, the cDNA sequence of grass carp ctgf gene was cloned by rapid amplification of cDNA ends (RACE) method; then, the characteristics of this g ...
DOI:
10.1007/s10695-019-00653-2

91. Cold temperature tolerance of albino rainbow shark (Epalzeorhynchos frenatum), a tropical fish with transgenic application in the ornamental aquarium trade

Author:
R.A. Leggatt
Source:
Canadian journal of zoology 2019 v.97 no.4 pp. 376-378
ISSN:
1480-3283
Subject:
Danio rerio; Gymnocorymbus ternetzi; Puntius; albino; aquarium fish; cold; cold tolerance; color; condition factor; fluorescent proteins; genetically modified organisms; lethal dose 50; sharks; socioeconomic status; trade; transgenesis; tropical fish; water temperature; winter; Canada
Abstract:
... Application of fluorescent protein transgenesis has commercial use for the ornamental aquarium trade by creating new colour phenotypes in various species. To determine the potential for transgenic ornamental aquarium fish to overwinter in Canada, the minimum temperature tolerance of albino rainbow shark (Epalzeorhynchos frenatum (Fowler, 1934)) was estimated to complement a previous study examinin ...
DOI:
10.1139/cjz-2018-0208

92. Collaborative assembly of doxorubicin and galactosyl diblock glycopolymers for targeted drug delivery of hepatocellular carcinoma

Author:
Jianghua Li; Yang Zhang; Chao Cai; Xiaozhi Rong; Meng Shao; Jiarui Li; Chendong Yang; Guangli Yu
Source:
Biomaterials science 2019 v.8 no.1 pp. 189-200
ISSN:
2047-4849
Subject:
Danio rerio; Fourier transform infrared spectroscopy; acrylamides; adsorption; adverse effects; antineoplastic activity; doxorubicin; drug delivery systems; drug therapy; encapsulation; galactosamine; genetically modified organisms; hepatoma; human cell lines; hydrophilicity; models; moieties; nanoparticles; nuclear magnetic resonance spectroscopy; pain; patients; polymerization; tetrabutylammonium compounds; transmission electron microscopy
Abstract:
... Hepatocellular carcinoma (HCC) patients suffer from severe pain due to the serious systemic side effects and low efficiency of chemotherapeutic drugs, and it is important to develop novel drug delivery systems to circumvent these issues. In this study, a series of galactose-based glycopolymers, poly(N-(prop-2-enoyl)-β-d-galactopyranosylamine)-b-poly(N-isopropyl acrylamide) (pGal(OH)-b-pNIPAA), wer ...
DOI:
10.1039/c9bm01604j

93. Combination of [12]aneN₃ and Triphenylamine-Benzylideneimidazolone as Nonviral Gene Vectors with Two-Photon and AIE Properties

Author:
Ming-Xuan Liu; Le-Le Ma; Xu-Ying Liu; Jin-Yu Liu; Zhong-Lin Lu; Rui Liu; Lan He
Source:
ACS applied materials & interfaces 2019 v.11 no.46 pp. 42975-42987
ISSN:
1944-8252
Subject:
Danio rerio; absorption; carboxylic ester hydrolases; emissions; fluorescence; fluorescence emission spectroscopy; gel electrophoresis; genes; hydrophilicity; luciferase; moieties; pH; single-stranded DNA; spectral analysis; transfection
Abstract:
... Three nonviral gene vectors, TPA-BI-A/B/C, have been designed and synthesized by the combination of one or two hydrophilic [12]aneN₃ moieties and two-photon fluorescent triphenylamine-benzylideneimidazolone (TPA-BI) units through different ester linkage. Spectroscopic characterization demonstrated that TPA-BI-A/B/C had strong aggregation-induced emissions (AIE), large Stokes shifts (230, 284, and ...
DOI:
10.1021/acsami.9b15169

94. Combined effects of environmental xeno-estrogens within multi-component mixtures: Comparison of in vitro human- and zebrafish-based estrogenicity bioassays

Author:
Hélène Serra; Martin Scholze; Rolf Altenburger; Wibke Busch; Hélène Budzinski; François Brion; Selim Aït-Aïssa
Source:
Chemosphere 2019 v.227 pp. 334-344
ISSN:
0045-6535
Subject:
Danio rerio; additive effect; benzo(a)pyrene; bioassays; bisphenol A; estrogen receptors; estrogenic properties; fish; freshwater; genes; genistein; hepatocytes; humans; ligands; models; pollutants; propiconazole
Abstract:
... Some recent studies showed that in vitro bioassays based on fish or human estrogen receptor (ER) activation may have distinct responses to environmental samples, highlighting the need to better understand bioassay-specific ER response to environmental mixtures. For this purpose, we investigated a 12-compound mixture in two mixture ratios (M1 and M2) on zebrafish (zf) liver cells stably expressing ...
DOI:
10.1016/j.chemosphere.2019.04.060

95. Combined effects of increased temperature and levonorgestrel exposure on zebrafish female liver, using stereology and immunohistochemistry against catalase, CYP1A, HSP90 and vitellogenin

Author:
P.G. Cardoso; R. Resende-de-Oliveira; E. Rocha
Source:
Environmental pollution 2019 v.252 pp. 1059-1067
ISSN:
0269-7491
Subject:
Danio rerio; adults; aquatic ecosystems; catalase; climate change; drugs; females; fish; glycogen; hepatocytes; immunohistochemistry; liver; metabolism; progestational hormones; temperature; toxic substances; vitellogenin
Abstract:
... Climate change and pharmaceuticals contamination constitute two of the most relevant stressors on the aquatic ecosystems, however, there is a huge lack of information regarding the interactive effects of both stressors. For that, a mesocosm experiment was implemented where adult zebrafish were exposed to combined temperature and the progestin levonorgestrel (LNG) for 21 days. Considering that the ...
DOI:
10.1016/j.envpol.2019.06.058

96. Combined effects of polystyrene microplastics and natural organic matter on the accumulation and toxicity of copper in zebrafish

Author:
Ruxia Qiao; Kai Lu; Yongfeng Deng; Hongqiang Ren; Yan Zhang
Source:
Science of the total environment 2019 v.682 pp. 128-137
ISSN:
0048-9697
Subject:
Danio rerio; adsorption; bioaccumulation; copper; heavy metals; liver; malondialdehyde; metallothionein; microplastics; organic matter; oxidative stress; pH; pollutants; polystyrenes; superoxide dismutase; toxicity; transcriptomics
Abstract:
... As emerging contaminants, microplastics (MPs) are predicted to act as vectors for other contaminants and their combined effects are largely unknown. In this study, the combined effects of MPs and natural organic matter (NOM) on the accumulation and toxicity of copper (Cu) in zebrafish (Danio rerio) were investigated. As a result, small-size MPs could absorb more Cu than large-size MPs. The presenc ...
DOI:
10.1016/j.scitotenv.2019.05.163

97. Comparative Lipid Peroxidation and Apoptosis in Embryo‐Larval Zebrafish Exposed to 3 Azole Fungicides, Tebuconazole, Propiconazole, and Myclobutanil, at Environmentally Relevant Concentrations

Author:
N. Kumar; O. Awoyemi; A. Willis; C. Schmitt; L. Ramalingam; N. Moustaid‐Moussa; J. Crago
Source:
Environmental toxicology and chemistry 2019 v.38 no.7 pp. 1455-1466
ISSN:
0730-7268
Subject:
Danio rerio; acute exposure; adverse effects; apoptosis; aquatic environment; aquatic organisms; biomarkers; caspase-3; caspase-9; cytochrome P-450; embryo (animal); gene expression; glutathione transferase; lipid peroxidation; mechanism of action; messenger RNA; mitochondria; models; myclobutanil; oxidative stress; phosphoproteins; propiconazole; runoff; tebuconazole; toxicity
Abstract:
... Azole fungicides have entered the aquatic environment through agricultural and residential runoff. In the present study, we compared the off‐target toxicity of tebuconazole, propiconazole, and myclobutanil using embryo‐larval zebrafish as a model. The aim of the present study was to investigate the relative toxicity of tebuconazole, propiconazole, and myclobutanil using multiple‐level endpoints su ...
DOI:
10.1002/etc.4429

98. Comparative analysis of endocrine disrupting effects of major phthalates in employed two cell lines (MVLN and H295R) and embryonic zebrafish assay

Author:
Hyojin Lee; Jungeun Lee; Kyungho Choi; Ki-Tae Kim
Source:
Environmental research 2019 v.172 pp. 319-325
ISSN:
0013-9351
Subject:
Danio rerio; binding capacity; cell lines; chronic exposure; diethyl phthalate; dimethyl phthalate; embryo (animal); estrogen receptors; genes; larvae; steroid hormones; steroidogenesis; transcription (genetics)
Abstract:
... Endocrine disruption potentials of phthalates have been widely recognized, but relatively little is known about relative potency of major phthalates. In the present study, six phthalates were chosen, i.e., dimethyl phthalate (DMP), diethyl phthalate (DEP), di(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DnOP), diisononyl phthalate (DINP) and diisodecyl phthalate (DIDP), and their endocrin ...
DOI:
10.1016/j.envres.2019.02.033

99. Comparative in Vitro and in Vivo Evaluation of the Estrogenic Effect of Hexafluoropropylene Oxide Homologues

Author:
Yan Xin; Xiao-Min Ren; Bin Wan; Liang-Hong Guo
Source:
Environmental science & technology 2019 v.53 no.14 pp. 8371-8380
ISSN:
1520-5851
Subject:
Danio rerio; bioaccumulation; computer simulation; environmental science; estrogen receptors; estrogenic properties; fluorescence; industry; ligands; models; perfluorooctanoic acid; toxicity; transcription (genetics); vitellogenin
Abstract:
... As alternatives to perfluorooctanoic acid (PFOA), hexafluoropropylene oxide (HFPO) homologues, including hexafluoropropylene oxide dimer acid (HFPO-DA), hexafluoropropylene oxide trimer acid (HFPO-TA), and hexafluoropropylene oxide tetramer acid (HFPO-TeA), have been used in the fluoropolymer industry for a long period of time. These compounds have attracted widespread attention in recent years du ...
DOI:
10.1021/acs.est.9b01579

100. Comparative studies on duplicated tdrd7 paralogs in teleosts: Molecular evolution caused neo-functionalization

Author:
Bo Wang; Xinxin Du; Huizhen Wang; Chaofan Jin; Chen Gao; Jinxiang Liu; Quanqi Zhang
Source:
Comparative biochemistry and physiology 2019 v.30 pp. 347-357
ISSN:
1744-117X
Subject:
3' untranslated regions; Danio rerio; Lepisosteus oculatus; Paralichthys olivaceus; adults; bioinformatics; embryo (animal); flounder; genes; genomics; germ cells; gonads; mammals; phylogeny; proteins; tissues; transcriptome
Abstract:
... The third-round whole genome duplication (3R-WGD) event occurred in the stem lineage of teleost during evolution, and is considered to be responsible for the biological diversification of ray-finned fishes. TUDOR domain containing protein 7 (Tdrd7), which belongs to the Tudor family proteins has been widely discussed in mammals. However, information about this gene in teleost is still lacking. In ...
DOI:
10.1016/j.cbd.2019.04.006