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- Author:
- Tingting Fang; Yuan Fang; Xiaojing Xu; Mingyan He; Zhiying Zhao; Peixin Huang; Feifei Yuan; Mengzhou Guo; Biwei Yang; Jinglin Xia
- Source:
- Journal of ethnopharmacology 2019 v.231 pp. 474-485
- ISSN:
- 0378-8741
- Subject:
- Actinidia chinensis; Oriental traditional medicine; animal models; antineoplastic activity; apoptosis; cell proliferation; cell viability; cytotoxicity; diuresis; gene expression; gene expression regulation; genes; hemostasis; hepatoma; herbs; messenger RNA; metastasis; patients; prognosis; quantitative polymerase chain reaction
- Abstract:
- ... Numerous studies have demonstrated the potent anticancer activity of various Chinese herbs. Actinidia chinensis Planch root (acRoots), a traditional Chinese medicine, functions as an antitumor and detoxifying agent and plays a role in diuresis and hemostasis. Treatment with acRoots confers strong inhibition of tumor growth in various forms of cancer. Here, we evaluated the anticancer activity and ...
- DOI:
- 10.1016/j.jep.2018.11.014
- https://doi.org/10.1016/j.jep.2018.11.014
- Author:
- Jin-Mu Yi; Sarah Shin; No Soo Kim; Ok-Sun Bang
- Source:
- BMC complementary and alternative medicine 2019 v.19 no.1 pp. 339
- ISSN:
- 1472-6882
- Subject:
- Forsythia suspensa; Oriental traditional medicine; adverse effects; alternative medicine; antibodies; antineoplastic activity; antineoplastic agents; colorectal neoplasms; cytotoxicity; dried fruit; drug therapy; fruits; ganglia; herbal medicines; human diseases; immunohistochemistry; liquid chromatography; males; models; neoplasm cells; nerve growth factor; neurites; neuroprotective effect; neurotoxicity; patients; peripheral nervous system diseases; quality of life; staining; viability assays
- Abstract:
- ... BACKGROUND: The dried fruits of Forsythia suspensa has generally been used to clear heat and detoxify in traditional Korean and Chinese medicine. Oxaliplatin is a first-line treatment chemotherapeutic agent for advanced colorectal cancer, but it induces peripheral neuropathy as an adverse side effect affecting the treatment regimen and the patient’s quality of life. The present study was conducted ...
- DOI:
- 10.1186/s12906-019-2761-8
- PubMed:
- 31783843
- PubMed Central:
- PMC6884752
- https://doi.org/10.1186/s12906-019-2761-8
- Author:
- Yi LV; Kwok-Fai SO; Nai-Kei WONG; Jia XIAO
- Source:
- Chinese journal of natural medicines 2019 v.17 no.1 pp. 43-49
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; antineoplastic activity; apoptosis; dietary supplements; disease control; garlic; models; neoplasms; organic sulfur compounds
- Abstract:
- ... While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract (AGE) exhibits stronger anti-cancer act ...
- DOI:
- 10.1016/S1875-5364(19)30008-1
- https://doi.org/10.1016/S1875-5364(19)30008-1
4. Botany, traditional uses, phytochemistry, pharmacology and toxicology of Ilex pubescens Hook et Arn
- Author:
- Shiqin Jiang; Hui Cui; Peng Wu; Zhongqiu Liu; Zhongxiang Zhao
- Source:
- Journal of ethnopharmacology 2019 pp. -
- ISSN:
- 0378-8741
- Subject:
- Ilex pubescens; Oriental traditional medicine; antineoplastic activity; asthma; blood circulation; cold; herbs; lignans; pain; pharmacokinetics; phytochemicals; protective effect; roots; stems; stroke; systematic review; therapeutics; toxicology; triterpenoids; China
- Abstract:
- ... Ilex pubescens (I. pubescens), which is well known in Chinese as Mao-Dong-Qing, is widely used in traditional Chinese medicine. This plant is distributed in the wild in southern China, and the roots and stems are used for clearing heat, detoxifying, activating blood circulation and dispelling stasis. Moreover, it is used for treating wind-heat cold, lung-heat asthma, swelling and pain due to phary ...
- DOI:
- 10.1016/j.jep.2019.112147
- https://doi.org/10.1016/j.jep.2019.112147
5. Changes in chemical components and antitumor activity during the heating process of Fructus Arctii
- Author:
- Jing Hu; Yun Shi; Bing Yang; Zibo Dong; Xinxin Si; Kunming Qin
- Source:
- Pharmaceutical biology 2019 v.57 no.1 pp. 363-368
- ISSN:
- 1744-5116
- Subject:
- Arctium lappa; Oriental traditional medicine; antineoplastic activity; chemical composition; chlorogenic acid; cytotoxicity; dried fruit; heat; high performance liquid chromatography
- Abstract:
- ... Context: The dried fruits of Arctium lappa L. have been used in two forms in traditional Chinese medicine; crude and stir-heating Fructus Arctii. However, its processed product possesses better activity. Objective: In this study, the chemical constituents of both crude and processed Fructus Arctii and their antiproliferative activities were evaluated. Materials and methods: The seven main active c ...
- DOI:
- 10.1080/13880209.2019.1616778
- PubMed:
- 31295042
- PubMed Central:
- PMC6691782
- https://doi.org/10.1080/13880209.2019.1616778
- Author:
- Bolin Xiang; Xiaodong Yu; Bo Li; Yan Xiong; Min Long; Qiyi He
- Source:
- Journal of food biochemistry 2019 v.43 no.7 pp. e12899
- ISSN:
- 0145-8884
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Duchesnea indica; Fourier transform infrared spectroscopy; Oriental traditional medicine; anion exchange; antineoplastic activity; antioxidant activity; antioxidants; arabinose; cellulose; dose response; ethanol; fever; food industry; free radicals; functional foods; galactose; gel chromatography; glucosamine; glucose; hemorrhage; human cell lines; immunomodulators; inflammation; inhibitory concentration 50; leprosy; mannose; molecular weight; neoplasms; pharmaceutical industry; scanning electron microscopes; therapeutics; ultraviolet-visible spectroscopy
- Abstract:
- ... A neutral polysaccharide (DIP‐1) from Duchesnea indica (Andr.) Focke was obtained by hot water extraction, ethanol precipitation and chromatographic separation (DEAE‐52 cellulose anion‐exchange column and Sephadex G‐100 gel column). The physicochemical properties of DIP‐1 were elucidated by gel permeation chromatography, monosaccharide composition, Fourier transform infrared spectrometry, UV–visib ...
- DOI:
- 10.1111/jfbc.12899
- https://doi.org/10.1111/jfbc.12899
- Author:
- Mohamad Hesam Shahrajabian; Wenli Sun; Qi Cheng
- Source:
- Acta agriculturæ Scandinavica 2019 v.69 no.6 pp. 546-556
- ISSN:
- 1651-1913
- Subject:
- Oriental traditional medicine; Zingiber officinale; analgesic effect; anti-inflammatory activity; antineoplastic activity; antioxidants; ascorbic acid; baked goods; calcium; cold; constipation; cytotoxicity; dementia; fever; flavonoids; food industry; ginger; herbal medicines; hypertension; indigestion; infectious diseases; iron; leaves; magnesium; medicinal plants; nutritive value; oils; pain; pharmaceutical industry; phenolic compounds; pickles; preservatives; rheumatoid arthritis; sauces; sesquiterpenoids; soft drinks; sweets; vomiting; China
- Abstract:
- ... Ginger (Zingiber officinale) has been used as a spice and medicine for over 200 years in Traditional Chinese Medicine. It is an important plant with several medicinal, and nutritional values used in Asian and Chinese Tradition medicine. Ginger and its general compounds such as Fe, Mg, Ca, vitamin C, flavonoids, phenolic compounds (gingerdiol, gingerol, gingerdione and shogaols), sesquiterpenes, pa ...
- DOI:
- 10.1080/09064710.2019.1606930
- https://doi.org/10.1080/09064710.2019.1606930
- Author:
- Lan Ma; Xue Zhang; Xiaoming Xu; Yuehai Ke; Jin Dai; Hongqiang Cheng; Wei Mao
- Source:
- Journal of ethnopharmacology 2019 v.231 pp. 507-515
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; antineoplastic activity; cardiovascular diseases; cytotoxicity; herbs; polymerization; tubulin
- Abstract:
- ... The concept of the prescription in Traditional Chinese Medicine (TCM) is usually characterized by the compatibility principle “monarch, minister, assistant, and guide”, which means herbs play primary, secondary, auxiliary, or harmonic roles, respectively, to achieve the optimally holistic effect. Following this compatibility principle, the Tanyu Tongzhi Formula (TTF), used for many years to treat ...
- DOI:
- 10.1016/j.jep.2018.11.043
- https://doi.org/10.1016/j.jep.2018.11.043
- Author:
- Jianjian Zhuang; Juxin Yin; Chaojian Xu; Mengmeng Jiang; Shaowu Lv
- Source:
- RSC advances 2019 v.9 no.67 pp. 39124-39132
- ISSN:
- 2046-2069
- Subject:
- Oriental traditional medicine; Western blotting; antineoplastic activity; apoptosis; autophagy; bioactive compounds; cancer therapy; genes; irradiation; membrane potential; mitochondrial membrane; myeloid leukemia; neoplasm cells; physical therapy; proteins; reactive oxygen species
- Abstract:
- ... Autophagy is an important mechanism for cell death regulation. To improve the anticancer effect during the treatment of leukemia and promote the apoptosis of leukemic cells, it is important to define the relationship between autophagy and apoptosis. A key bioactive compound in traditional Chinese medicine, 20(s)-Ginsenoside (GRh2), demonstrated an advancement in leukemia treatment. Blue LED therap ...
- DOI:
- 10.1039/c9ra08049j
- https://doi.org/10.1039/c9ra08049j
- Author:
- Jia Fu; Yanni Lv; Qianqian Jia; Yuanyuan Lin; Shengli Han
- Source:
- Talanta 2019 v.192 pp. 248-254
- ISSN:
- 0039-9140
- Subject:
- Oriental traditional medicine; antineoplastic activity; bioactive compounds; blood circulation; blood stasis; cell viability; enzyme activity; epidermal growth factor receptors; fibroblast growth factor receptor 4; herbal medicines; high performance liquid chromatography; models; salvianolic acid; screening; China
- Abstract:
- ... Radix Salviae Miltiorrhiae (also known as DanShen (DS) in China), a popular herbal drug in traditional Chinese medicine (TCM) for promoting blood circulation and treating blood stasis, has been reported to possess potential anti-tumor effects. The aim of the study was to develop an effective and practical method for screening and identifying bioactive compounds from Radix Salviae Miltiorrhiae. In ...
- DOI:
- 10.1016/j.talanta.2018.09.053
- https://doi.org/10.1016/j.talanta.2018.09.053
- Author:
- Hongqing Xie; Xiaotong Li; Yajie Chen; Mingzi Lang; Zhangfei Shen; Liangen Shi
- Source:
- Journal of ethnopharmacology 2019 v.231 pp. 230-240
- ISSN:
- 0378-8741
- Subject:
- Cordyceps; Oriental traditional medicine; Western blotting; adenine; adenosine; antineoplastic activity; antineoplastic agents; apoptosis; calcium; caspase-12; caspase-3; caspase-6; caspase-8; caspase-9; cell cycle checkpoints; cell lines; cyclin-dependent kinase; cyclins; cytochrome c; cytosol; dose response; endoplasmic reticulum; endoplasmic reticulum stress; flow cytometry; fluorescent dyes; high performance liquid chromatography; humans; interphase; membrane potential; mitochondria; mitochondrial membrane; neoplasm cells; staining; stomach neoplasms; therapeutics; toxicity; toxicity testing; uridine
- Abstract:
- ... Cordyceps cicadae (Miq.) Massee is a traditional Chinese medicine that has been used for approximately 1600 years in China. C. cicadae, a member of the Cordyceps genus, exerts a therapeutic effect on many diseases, such as cancer.This study aimed to evaluate the antineoplasmic activity of C. cicadae and to identify its molecular mechanism of cell death.The toxicity of the ethanolic extract of C. c ...
- DOI:
- 10.1016/j.jep.2018.11.028
- https://doi.org/10.1016/j.jep.2018.11.028
- Author:
- Jen‐Yang Tang; Sheng‐Yao Peng; Yuan‐Bin Cheng; Chun‐Lin Wang; Ammad Ahmad Farooqi; Tzu‐Jung Yu; Ming‐Feng Hou; Sheng‐Chieh Wang; Chia‐Hung Yen; Leong‐Perng Chan; Fu Ou‐Yang; Hsueh‐Wei Chang
- Source:
- Environmental toxicology 2019 v.34 no.8 pp. 891-901
- ISSN:
- 1520-4081
- Subject:
- DNA damage; NAD ADP-ribosyltransferase; Nepenthes; Oriental traditional medicine; Western blotting; acetylcysteine; antineoplastic activity; apoptosis; cell cycle; cell viability; ethyl acetate; flow cytometry; inhibitory concentration 50; membrane potential; mitochondria; mitochondrial membrane; mouth neoplasms; neoplasm cells; oxidative stress; reactive oxygen species
- Abstract:
- ... Nepenthes plants are regarded as a kind of Traditional Chinese Medicine for several diseases but its anticancer activity remain unclear. The subject of this study is to evaluate the antiproliferation effects on oral cancer cells by Nepenthes plants using ethyl acetate extract of Nepenthes adrianii x clipeata (EANA). Cell viability was detected using MTS assay. Its detailed mechanisms including cel ...
- DOI:
- 10.1002/tox.22748
- https://doi.org/10.1002/tox.22748
- Author:
- Chunwei Jiao; Wang Chen; Xupeng Tan; Huijia Liang; Jieyi Li; Hao Yun; Chunyan He; Jiaming Chen; Xiaowei Ma; Yizhen Xie; Burton B. Yang
- Source:
- Journal of ethnopharmacology 2019 pp. -
- ISSN:
- 0378-8741
- Subject:
- B-lymphocytes; Ganoderma lucidum; NAD ADP-ribosyltransferase; Oriental traditional medicine; Western blotting; antineoplastic activity; apoptosis; breast neoplasms; caspase-3; caspase-8; caspase-9; cell viability; enzyme inhibitors; gene expression; immunohistochemistry; lipids; messenger RNA; mice; mitochondria; mushrooms; neoplasm cells; oils; protein content; proteins; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; spores; tumor necrosis factors
- Abstract:
- ... The mushroom Ganoderma lucidum (G. lucidum) is a traditional Chinese medicine reported to have a variety of pharmacological properties, including anti-cancer activity. G. lucidum spore oil (GLSO) is a lipid substance extracted from sporoderm-broken spore of G. lucidum. However, the effect of GLSO on breast cancer and the underlying molecular mechanism remain unclear.The aim of this study was to id ...
- DOI:
- 10.1016/j.jep.2019.112256
- https://doi.org/10.1016/j.jep.2019.112256
- Author:
- Chong Li; Guangbin Huang; Fang Tan; Xianrong Zhou; Jianfei Mu; Xin Zhao
- Source:
- Journal of food quality 2019 v.2019 pp. -
- ISSN:
- 0146-9428
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Apocynum venetum; Oriental traditional medicine; antineoplastic activity; antioxidant activity; antioxidant genes; apoptosis; bioactive compounds; caspase-3; caspase-9; catalase; cell proliferation; cell viability; chlorogenic acid; cytotoxicity; dose response; free radical scavengers; free radicals; gene expression; gene expression regulation; glutathione peroxidase; hepatoma; high performance liquid chromatography; human cell lines; human diseases; hydrogen peroxide; in vitro studies; kidneys; leaves; messenger RNA; polyphenols; protective effect; quantitative polymerase chain reaction; quercetin; reverse transcriptase polymerase chain reaction; rosmarinic acid; rutin; spectroscopy; sulfonic acids; superoxide dismutase; survival rate; tea; toxicity testing
- Abstract:
- ... The dry leaf of Apocynum venetum tea extracts (AVTEs) belonging to the Apocynaceae family is a traditional Chinese medicine. The aim of this study is to identify the bioactive components of AVTE and analyse its antioxidant and anticancer activity in vitro. Method. Flavones and polyphenols in AVTE were determined by high-performance liquid chromatography (HPLC) assay. The scavenging capacity of tea ...
- DOI:
- 10.1155/2019/2465341
- https://doi.org/10.1155/2019/2465341
- Author:
- Biqiang Zhu; Lei Zhao; Yang Liu; Ye Jin; Jing Feng; Fuya Zhao; Jiayu Sun; Rui Geng; Yunwei Wei
- Source:
- international journal of biochemistry & cell biology 2019 v.108 pp. 98-110
- ISSN:
- 1357-2725
- Subject:
- Euodia; Oriental traditional medicine; alkaloids; antineoplastic activity; antineoplastic agents; apoptosis; carcinoma; cell movement; cell proliferation; enzymes; humans; in vivo studies; interleukin-6; mice; neoplasm cells; small interfering RNA; therapeutics
- Abstract:
- ... Cholangiocarcinoma (CCA) is one of the most common fatal carcinomas and is well known to be lack of effective treatment. Thus, novel therapeutic strategies are greatly needed. Evodiamine, a quinozole alkaloid isolated from evodia rutaecarpa Bentham, has been demonstrated to exhibit anti-tumor effects on many cancer cells. However, little is known in terms of the effects on cholangiocarcinoma. In t ...
- DOI:
- 10.1016/j.biocel.2019.01.012
- https://doi.org/10.1016/j.biocel.2019.01.012
- Author:
- Fei-Fei FENG; Peng CHENG; Chao SUN; Hui WANG; Wei WANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.10 pp. 768-777
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Paris polyphylla; antineoplastic activity; apoptosis; autophagy; carcinogenesis; cell growth; cell proliferation; cisplatin; enzyme inhibitors; humans; lung neoplasms; oncogene proteins; phosphoprotein phosphatase
- Abstract:
- ... Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a human oncoprotein that is overexpressed in multiple kinds of cancers including non-small cell lung cancer (NSCLC). CIP2A plays an ‘oncogenic nexus’ to participate in the tumorigenesis and chemoresistance in several cancer types. AKT and mTORC1 overactivation are detected in NSCLC and many other cancers. Previous studies found that the CIP2 ...
- DOI:
- 10.1016/S1875-5364(19)30093-7
- https://doi.org/10.1016/S1875-5364(19)30093-7
- Author:
- Yan-bo Lv; Qing Zhou; Yang Fan; Jiu-liang Zhang
- Source:
- Journal of ethnopharmacology 2019 v.241 pp. 111920
- ISSN:
- 0378-8741
- Subject:
- Cuora; Mauremys mutica; Oriental traditional medicine; Terrapene; amino acid sequences; antineoplastic activity; blood serum; body weight changes; cyclophosphamide; enzymatic hydrolysis; enzyme activity; glutathione peroxidase; high performance liquid chromatography; immunosuppression; mice; polypeptides; proteinases; spleen; superoxide dismutase; thymus gland; turtles; China
- Abstract:
- ... Mauremys mutica (Asian yellow pond turtle, YPT) and Cuora trifasciata (Chinese three-striped box turtle, TBT) are traditional Chinese medicine. They possess many biological characteristics, such as immune-enhancement, anti-inflammatory, anti-cancer effects. They have been used as folk anti-cancer drugs in central and southern China for a long time. However, there was no reports of comparing the im ...
- DOI:
- 10.1016/j.jep.2019.111920
- https://doi.org/10.1016/j.jep.2019.111920
- Author:
- Zheng LI; Qian-Qian CHEN; Christopher Wai Kei LAM; Jian-Ru GUO; Wei-Jia ZHANG; Cai-Yun WANG; Vincent Kam Wai WONG; Mei-Cun YAO; Wei ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 608-615
- ISSN:
- 1875-5364
- Subject:
- DNA replication; Oriental traditional medicine; adenocarcinoma; antineoplastic activity; cell cycle checkpoints; cell lines; cytotoxicity; epithelial cells; humans; hydroxyurea; interphase; liquid chromatography; lungs; mass spectrometry; metabolism; metabolomics; nucleosides; resveratrol
- Abstract:
- ... In an effort to understand the molecular events contributing to the cytotoxicity activity of resveratrol (RSV), we investigated its effects on human lung adenocarcinoma epithelial cell line A549 at different concentrations. Cellular nucleoside metabolic profiling was determined by an established liquid chromatography-mass spectrometry method in A549 cells. RSV resulted in significant decreases and ...
- DOI:
- 10.1016/S1875-5364(19)30063-9
- https://doi.org/10.1016/S1875-5364(19)30063-9
- Author:
- Wen-Xia GONG; Yu-Zhi ZHOU; Xue-Mei QIN; Guan-Hua DU
- Source:
- Chinese journal of natural medicines 2019 v.17 no.4 pp. 264-274
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; antineoplastic activity; apoptosis; calcium; cell viability; corticosterone; lactate dehydrogenase; mitochondria; neuroprotective effect; rats; rhizomes; sesquiterpenoids; therapeutics
- Abstract:
- ... Atractylenolide III (ATL-III), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanisms of ATL-III on corticosterone injured rat phaeochromocytoma (PC12) cells. Our re ...
- DOI:
- 10.1016/S1875-5364(19)30030-5
- https://doi.org/10.1016/S1875-5364(19)30030-5
- Author:
- Zujun Que; Zhiyi Zhou; Bin Luo; Changsheng Dong; Yi Jiang; Hegen Li; Jianhui Tian
- Source:
- BMC complementary and alternative medicine 2019 v.19 no.1 pp. 204
- ISSN:
- 1472-6882
- Subject:
- DNA damage; Oriental traditional medicine; Western blotting; alternative medicine; antineoplastic activity; apoptosis; caspase-3; cell proliferation; death; dose response; drugs; flow cytometry; humans; interphase; lung neoplasms; metastasis; neoplasm cells
- Abstract:
- ... BACKGROUND: Metastasis is the main cause of lung cancer death. As a seed of metastasis, circulating tumor cells are an important target for metastasis intervention. The traditional Chinese medicine, Jinfukang, has been clinically available for the treatment of non-small cell lung cancer (NSCLC). In this study, we investigated the action and underlying mechanisms of Jinfukang against circulating lu ...
- DOI:
- 10.1186/s12906-019-2601-x
- PubMed:
- 31391058
- PubMed Central:
- PMC6686466
- https://doi.org/10.1186/s12906-019-2601-x
- Author:
- Qing Lin; Mengke Qu; Hirak K. Patra; Shanshan He; Luyao Wang; Xun Hu; Linyu Xiao; Yu Fu; Tao Gong; Qin He; Ling Zhang; Xun Sun; Zhirong Zhang
- Source:
- Journal of ethnopharmacology 2019 pp. -
- ISSN:
- 0378-8741
- Subject:
- Fritillaria cirrhosa; Oriental traditional medicine; Western blotting; active ingredients; adverse effects; animal models; antineoplastic activity; antineoplastic agents; blood cell counts; cancer therapy; case studies; cell lines; cytotoxicity; drug delivery systems; enzyme-linked immunosorbent assay; films (materials); herbal medicines; histopathology; immunohistochemistry; in vivo studies; inflammation; lung neoplasms; mice; transcription factor NF-kappa B
- Abstract:
- ... Bulbus Fritillaria cirrhosa D. Don (BFC) is a Chinese traditional herbal medicine that has long been used as an indispensable component in herbal prescriptions for bronchopulmonary diseases due to its well-established strong anti-inflammation and pulmonary harmonizing effects. Interestingly, there are few case reports in traditional Chinese medicine available where they found it to contribute in a ...
- DOI:
- 10.1016/j.jep.2019.112283
- https://doi.org/10.1016/j.jep.2019.112283
- Author:
- Tingting Cao; Jiushi Liu; Xiaoyi Zhang; Xueping Wei; Yaodong Qi; Bengang Zhang; Haitao Liu; Peigen Xiao
- Source:
- Analytical methods 2019 v.11 no.20 pp. 2700-2711
- ISSN:
- 1759-9679
- Subject:
- Carthamus tinctorius; Oriental traditional medicine; analytical methods; antineoplastic activity; climatic factors; discriminant analysis; flowers; immunosuppression; least squares; markets; melanin; metabolites; metabolomics; neuroprotective effect; phytogeography; principal component analysis; provenance; quality control; therapeutics; vasodilation; China
- Abstract:
- ... Flos Carthami, the dried flower of Carthamus tinctorius L. (Compositae), is among the most popular traditional Chinese medicines due to its diverse biological activities such as anticoagulation, vasodilation, antihypertension, antioxidation, neuroprotection, melanin production inhibition, immunosuppression and antitumor activity. At present, Carthamus tinctorius L. is cultivated in various regions ...
- DOI:
- 10.1039/c9ay00368a
- https://doi.org/10.1039/c9ay00368a
- Author:
- Juan Sun; Han-Yu Liu; Cheng-Zhi Lv; Jie Qin; Yuan-Feng Wu
- Source:
- Journal of agricultural and food chemistry 2019 v.67 no.34 pp. 9643-9651
- ISSN:
- 1520-5118
- Subject:
- Oriental traditional medicine; active ingredients; agonists; antineoplastic activity; drug design; food industry; glycyrrhetinic acid; licorice; peroxisome proliferator-activated receptor gamma; pharmaceutical industry; piperazine; toxicity
- Abstract:
- ... Licorice is a traditional Chinese medicine, which is often used as sweetener and cosmetic ingredients in food and pharmaceutical industries. Among them, glycyrrhetic acid is one of the most important agents. Studies have shown that glycyrrhetic acid exhibited antitumor activities as PPARγ agonist. However, the limited number of PPARγ glycyrrhetinic agonists and their high toxicity greatly limit th ...
- DOI:
- 10.1021/acs.jafc.9b03442
- https://doi.org/10.1021/acs.jafc.9b03442
- Author:
- Yalan Zhang; Yuhang Xiao; Qixing Dong; Wenjuan Ouyang; Qun Qin
- Source:
- Journal of food science 2019 v.84 no.4 pp. 904-910
- ISSN:
- 0022-1147
- Subject:
- Lotus; Oriental traditional medicine; alkaloids; antineoplastic activity; anxiety; cytotoxicity; dose response; enzyme inhibitors; heat-shock protein 90; herbal medicines; inhibitory concentration 50; messenger RNA; myeloid leukemia; neoplasm cells; patients; plumule; protein content; protein kinases; prototypes; relapse; sleep disorders; synergism; tea; therapeutics; thirst; tyrosine; China
- Abstract:
- ... Imatinib, the prototype BCR‐ABL tyrosine kinase inhibitor (TKI), is the first‐line treatment for Philadelphia chromosome‐positive chronic myeloid leukemia (CML) in the chronic phase. However, a subgroup of patients exhibit poor response or experience relapse. This issue may be overcome by combination therapy using natural compounds. Neferine, a major bisbenzylisoquinoline alkaloid extracted from “ ...
- DOI:
- 10.1111/1750-3841.14484
- https://doi.org/10.1111/1750-3841.14484
- Author:
- Xiang-rong Zhu; Hui Wang; Jian Sun; Bao Yang; Xue-wu Duan; Yue-ming Jiang
- Source:
- Journal of Zhejiang University 2019 v.20 no.6 pp. 503-512
- ISSN:
- 1673-1581
- Subject:
- longans; herbs; seed extracts; Dimocarpus longan; pain; pericarp; cardiovascular diseases; antineoplastic activity; Litchi chinensis; byproducts; enzyme inhibition; human health; aril; antioxidants; Oriental traditional medicine
- Abstract:
- ... Litchi (Litchi chinensis Sonn.) and longan (Dimocarpus longan Lour.) fruits have a succulent and white aril with a brown seed and are becoming popular worldwide. The two fruits have been used in traditional Chinese medicine as popular herbs in the treatment of neural pain, swelling, and cardiovascular disease. The pericarp and seed portions as the by-products of litchi and longan fruits are estima ...
- DOI:
- 10.1631/jzus.B1900161
- PubMed:
- 31090276
- PubMed Central:
- PMC6568221
- https://doi.org/10.1631/jzus.B1900161
- Author:
- Jianhua Li; Chenfei Tian; Yuhui Xia; Ishmael Mutanda; Kaibo Wang; Yong Wang
- Source:
- Metabolic engineering 2019 v.52 pp. 124-133
- ISSN:
- 1096-7176
- Subject:
- Arabidopsis thaliana; Escherichia coli; Medicago sativa; Oriental traditional medicine; Petroselinum crispum; Petunia hybrida; Rhodotorula; Scutellaria baicalensis; antineoplastic activity; apigenin; biochemical pathways; chalcone isomerase; chrysin; fermentation; genes; hosts; malonyl coenzyme A; medicinal plants; naringenin-chalcone synthase; phenylalanine; phenylalanine ammonia-lyase; tyrosine
- Abstract:
- ... Baicalein and scutellarein are bioactive flavones found in the medicinal plant Scutellaria baicalensis Georgi, used in traditional Chinese medicine. Extensive previous work has demonstrated the broad biological activity of these flavonoids, such as antifibrotic, antiviral and anticancer properties. However, their supply from plant material is insufficient to meet demand. Here, to provide an altern ...
- DOI:
- 10.1016/j.ymben.2018.11.008
- https://doi.org/10.1016/j.ymben.2018.11.008
- Author:
- Kei Kumakura; Chiaki Hori; Hiroki Matsuoka; Kiyohiko Igarashi; Masahiro Samejima
- Source:
- Journal of the science of food and agriculture 2019 v.99 no.2 pp. 529-535
- ISSN:
- 0022-5142
- Subject:
- Ganoderma lucidum; Oriental traditional medicine; antineoplastic activity; beta-N-acetylhexosaminidase; beta-glucanase; enzyme activity; fruiting bodies; glutamic acid; health foods; mushrooms; peptidyl-dipeptidase A; polysaccharides; proteinases; proteomics; surveys
- Abstract:
- ... BACKGROUND: Mushrooms have been widely considered as health foods as their extracts have anti‐hypertensive and anti‐tumor activities. After a thorough literature survey, we hypothesized that enzymes in mushroom extracts play an important role in synthesizing functional molecules. Therefore, in this study, proteins extracted from reishi mushroom (Ganoderma lucidum), which is used in oriental medici ...
- DOI:
- 10.1002/jsfa.9211
- https://doi.org/10.1002/jsfa.9211
- Author:
- Chenjuan Zeng; Qi Liao; Ye Hu; Yongmei Shen; Funeng Geng; Lijuan Chen
- Source:
- Journal of medical entomology 2019 v.56 no.6 pp. 1522-1526
- ISSN:
- 0022-2585
- Subject:
- Oriental traditional medicine; Periplaneta americana; antineoplastic activity; drug development; gastrointestinal system; heart failure; immune response; insects; medical entomology
- Abstract:
- ... The purpose of this review is to elaborate the role of Periplaneta (P.) americana L. in modern and traditional Chinese medicine (TCM) and compare the use of the species in these two forms of medical treatments. From searches on Google Scholar, PubMed, and Web of Science databases, studies were identified involving TCMs with P. americana, which have a history of use over several thousand years, and ...
- DOI:
- 10.1093/jme/tjz081
- https://doi.org/10.1093/jme/tjz081
- Author:
- Lei XIONG; Chang-Fa CHEN; Tao-Ling MIN; Hai-Feng HU
- Source:
- Chinese journal of natural medicines 2019 v.17 no.2 pp. 155-160
- ISSN:
- 1875-5364
- Subject:
- Chromobacterium violaceum; Oriental traditional medicine; antineoplastic activity; culture media; cytotoxicity; dipeptides; human cell lines; humans; inhibitory concentration 50; neoplasm cells; nuclear magnetic resonance spectroscopy
- Abstract:
- ... Romipeptides A and B (1 and 2), two new romidepsin derivatives, and three known compounds, chromopeptide A (3), romidepsin (4) and valine-leucine dipeptide (5) were isolated from the fermentation broth of Chromobacterium violaceum No. 968. Their structures were elucidated by interpretation of their UV, HR-ESI-MS and NMR spectra. The absolute configuration of compound 1 and 2 were established by si ...
- DOI:
- 10.1016/S1875-5364(19)30018-4
- https://doi.org/10.1016/S1875-5364(19)30018-4
- Author:
- Yonggui Song; Baixi Shan; Hanyun Li; Bingwei Feng; Hong Peng; Chen Jin; Pengfei Xu; Qiang Zeng; Zhou Liao; Pengqian Mu; Dan Su
- Source:
- Journal of ethnopharmacology 2019 v.235 pp. 435-445
- ISSN:
- 0378-8741
- Subject:
- Anemone chinensis; Oriental traditional medicine; acetaminophen; alanine transaminase; alkaline phosphatase; antineoplastic activity; aspartate transaminase; bacterial infections; biochemical pathways; biomarkers; blood chemistry; blood serum; chenodeoxycholic acid; human health; ionization; liver; liver function; mass spectrometry; metabolomics; oral administration; principal component analysis; rats; saponins; schistosomiasis; sphingomyelins; toxicity; ultra-performance liquid chromatography
- Abstract:
- ... Pulsatilla chinensis (Bunge) Regel is a valuable traditional Chinese medicine (TCM) which is widely used for the treatment of schistosomiasis, inflammatory, bacterial infections. In recent years, P chinensis has been reported to exhibit antitumor activities. However, the mechanisms underlying its toxic effects remain largely unresolved. This paper is designed to investigate the damage of long-term ...
- DOI:
- 10.1016/j.jep.2019.01.035
- https://doi.org/10.1016/j.jep.2019.01.035
- Author:
- Wen‐dan Zhang; Miao‐miao Jin; Hong‐hong Jiang; Jian‐xi Yang; Qiao Wang; Ying‐feng Du; Liang Cao; Hui‐jun Xu
- Source:
- Journal of separation science 2019 v.42 no.2 pp. 628-635
- ISSN:
- 1615-9306
- Subject:
- Oriental traditional medicine; antineoplastic activity; betulinic acid; biochemical pathways; biotransformation; condiments; fruits; intestinal microorganisms; mass spectrometry; metabolism; metabolites; methylation; oxidation; rats; solid phase extraction; ultra-performance liquid chromatography
- Abstract:
- ... Betulinic acid is a triterpenoid organic acid with remarkable antitumor properties and is naturally present in many fruits, condiments and traditional Chinese medicines. Currently, a strategy was developed for the identification of metabolites following the in vivo and in vitro biotransformation of Betulinic acid with rat intestinal bacteria utilizing ultra high performance liquid chromatography w ...
- DOI:
- 10.1002/jssc.201800960
- https://doi.org/10.1002/jssc.201800960
- Author:
- Kok-Tong Tan; Shiming Li; Yi Rong Li; Shih-Lung Cheng; Sheng-Hao Lin; Yu-Tang Tung
- Source:
- Applied biochemistry and biotechnology 2019 v.187 no.4 pp. 1328-1343
- ISSN:
- 0273-2289
- Subject:
- Oriental traditional medicine; active ingredients; adverse effects; antineoplastic activity; antineoplastic agents; apoptosis; caspase-3; caspase-8; caspase-9; cell lines; cell viability; drug synergism; drug therapy; flavones; herbs; lung neoplasms; mice; models; neoplasm cells; orange peels; paclitaxel; propidium
- Abstract:
- ... Lung cancer remains a highly prevalent disease and a leading cause of cancer-related deaths worldwide. Currently, exploring antitumor drugs derived from herbs used in traditional Chinese medicine is increasingly becoming an attractive area of research. Paclitaxel (PTX), a highly effective chemotherapeutic drug, is widely used for treating different cancers; however, the clinical use of PTX is dose ...
- DOI:
- 10.1007/s12010-018-2869-1
- https://doi.org/10.1007/s12010-018-2869-1
- Author:
- Peng-Cheng LIN; Lin-Lin JI; Xiang-Jian ZHONG; Jin-Jie LI; Xin WANG; Xiao-Ya SHANG; Sheng LIN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.1 pp. 22-26
- ISSN:
- 1875-5364
- Subject:
- Cirsium arvense; Oriental traditional medicine; animal ovaries; antineoplastic activity; cell lines; chemical structure; colorectal neoplasms; cytotoxicity; food plants; humans; inhibitory concentration 50; ovarian neoplasms; secretion; spectral analysis; triterpenoids; tumor necrosis factor-alpha
- Abstract:
- ... Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD d ...
- DOI:
- 10.1016/S1875-5364(19)30005-6
- https://doi.org/10.1016/S1875-5364(19)30005-6
- Author:
- Wei Peng; Yujie Liu; Meibian Hu; Mengmeng Zhang; Jing Yang; Fang Liang; Qinwan Huang; Chunjie Wu
- Source:
- Revista Brasileira de Farmacognosia 2019 v.29 no.1 pp. 111-124
- ISSN:
- 0102-695X
- Subject:
- Oriental traditional medicine; Toona sinensis; anti-inflammatory activity; antineoplastic activity; antioxidant activity; diabetes; drugs; flavonoids; glycemic effect; neoplasms; phenylpropanoids; terpenoids; therapeutics; toxicity; toxicology; Asia
- Abstract:
- ... Toona sinensis (Juss.) M.Roem, Meliaceae, a deciduous plant native to eastern and southeastern Asia, is widely used in Traditional Chinese Medicine. This paper was aimed to summarize the current advances in traditional usage, phytochemistry, pharmacology and toxicology of T. sinensis. In this review, various types of data of T. sinensis are discussed in the corresponding parts of this paper, and p ...
- DOI:
- 10.1016/j.bjp.2018.07.009
- PubMed:
- 32287507
- PubMed Central:
- PMC7103134
- https://doi.org/10.1016/j.bjp.2018.07.009
- Author:
- Min Zhao; Qiufang Chen; Wanfeng Xu; Hong Wang; Yuan Che; Mengqiu Wu; Lin Wang; Cao Lijuan; Haiping Hao
- Source:
- Journal of ethnopharmacology 2019 v.243 pp. 112093
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Panax ginseng; Western blotting; adjuvants; antineoplastic activity; autophagy; cell proliferation; cell structures; endoplasmic reticulum stress; fluorescent antibody technique; gene targeting; ginsenosides; humans; lung neoplasms; patients; quantitative polymerase chain reaction; transmission electron microscopes
- Abstract:
- ... Ginseng (Panax ginseng C. A. Mey) has been widely used in Asian countries for thousands of years. It has auxiliary anticancer efficacy and its derived preparations (e.g. Shenmai injection) are prescribed for cancer patients as Traditional Chinese Medicines clinically in China.Aim of the study: The involved adjuvant anticancer mechanisms of ginseng are still unknown. The present study evaluated the ...
- DOI:
- 10.1016/j.jep.2019.112093
- https://doi.org/10.1016/j.jep.2019.112093
- Author:
- Zihang Xu; Fei Zhang; Yangzhuangzhuang Zhu; Fei Liu; Xiao Chen; Luyao Wei; Ning Zhang; Qin Zhou; Hairong Zhong; Chao Yao; Xiaowen Zhu; Chenyuan Gong; Shiguo Zhu; Chunpu Zou
- Source:
- Journal of ethnopharmacology 2019 v.234 pp. 180-188
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Western blotting; antineoplastic activity; apoptosis; asthma; body weight; cell cycle checkpoints; cell proliferation; cough; cyclin-dependent kinase; cyclins; flow cytometry; heart; histology; kidneys; liver; lung neoplasms; lungs; mice; mitochondria; models; neoplasm cells; propidium; staining; therapeutics
- Abstract:
- ... Ze-Qi-Tang (ZQT), a classic Chinese herbal formula, has been for over thousand years used for the treatment of several respiratory ailments like cough, asthma, hydrothorax and lung cancer.Cumulative literature on ZQT herbal formula reveals that its several constituent components are potent inducer of apoptosis in different cancer cells. However, the activity of ZQT against non-small-cell-lung canc ...
- DOI:
- 10.1016/j.jep.2019.01.007
- https://doi.org/10.1016/j.jep.2019.01.007
- Author:
- Wen-Long Wei; Jin-Jun Hou; Xia Wang; Yang Yu; Hao-Jv Li; Zhen-Wei Li; Zi-Jin Feng; Hua Qu; Wan-Ying Wu; De-An Guo
- Source:
- Journal of ethnopharmacology 2019 v.237 pp. 215-235
- ISSN:
- 0378-8741
- Subject:
- Bufo; Oriental traditional medicine; adverse effects; anesthetics; animals; antimicrobial properties; antineoplastic activity; bioavailability; biochemical pathways; bufadienolides; cardiotoxicity; cell lines; clinical trials; databases; diarrhea; heat stroke; hydroxylation; indole alkaloids; metabolites; neoplasm cells; neoplasms; new drugs; pain; pharmacodynamics; pharmacokinetics; secretion; toxicology; vomiting
- Abstract:
- ... The animal medicine of Venenum Bufonis (VB), a product of the secretions of Bufo gargarizans Cantor or B. melanostictus Schneider, has long been used as a traditional Chinese medicine (TCM) for the treatment of sunstroke and faint, acute filthy disease - abdominal pain or vomiting and diarrhea, etc.This review is aimed at providing the comprehensive and up-to-date information of VB as regards its ...
- DOI:
- 10.1016/j.jep.2019.03.042
- https://doi.org/10.1016/j.jep.2019.03.042
- Author:
- Yingna Chen; Lei Bi; Huijuan Luo; Yucui Jiang; Feiyan Chen; Yunshan Wang; Guangwei Wei; Weiping Chen
- Source:
- Journal of ethnopharmacology 2019 v.232 pp. 11-20
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Panax ginseng; antineoplastic activity; body weight; cell proliferation; cisplatin; coculture; cytokines; drug therapy; gene expression; immunosuppression; intraperitoneal injection; macrophages; messenger RNA; mice; neoplasm cells; neoplasms; platinum; spleen; thymus gland; weight loss
- Abstract:
- ... In traditional Chinese medicine, supplementing Qi and strengthening body resistance are an important principle of anticancer treatment. Panax ginseng C.A.Mey. (ginseng) and Astragalus membranaceus Bunge (astragalus) are the representative herbs for this therapeutic principle.This study aims to explore the effect of the water extract of ginseng and astragalus (WEGA) on regulating macrophage polariz ...
- DOI:
- 10.1016/j.jep.2018.12.003
- https://doi.org/10.1016/j.jep.2018.12.003
- Author:
- Jian Wu; Xing-Xing Zhang; Xi Zou; Min Wang; Hong-xing Wang; Yao-hui Wang; Chang-yin Li; Lin-gang Zhao; Min Chen; Li-xia Pei; Shen-Lin Liu; Qing-Min Sun
- Source:
- Journal of ethnopharmacology 2019 v.235 pp. 56-64
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Western blotting; adhesion; antineoplastic activity; enzyme-linked immunosorbent assay; flow cytometry; genes; immunohistochemistry; macrophages; messenger RNA; mice; models; monocytes; patients; phenotypic plasticity; protein synthesis; quality of life; quantitative polymerase chain reaction; stomach neoplasms
- Abstract:
- ... Jianpi Yangzheng Xiaozheng Decoction (JPYZXZ) is an empirical compound prescription based on the theory of traditional Chinese medicine. JPYZXZ, which is “Qi-invigorating, spleen-strengthening and stasis-removing,” can improve the quality of life of gastric cancer patients and prolong their survival; however, the exact mechanism underlying the antitumor effects of this compound is still not clear. ...
- DOI:
- 10.1016/j.jep.2019.02.003
- https://doi.org/10.1016/j.jep.2019.02.003
- Author:
- Tao Liu; Jing Zhou; Hanjin Cui; Pengfei Li; Jiekun Luo; Teng Li; Feng He; Yang Wang; Tao Tang
- Source:
- Journal of ethnopharmacology 2019 v.232 pp. 244-254
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Western blotting; antineoplastic activity; bioinformatics; brain; calcium-binding proteins; drugs; energy metabolism; gene ontology; genes; hemorrhage; liquid chromatography; neurodevelopment; neurons; neuroprotective effect; oxidative stress; protein content; protein synthesis; proteomics; rats; rhubarb; synapse; tandem mass spectrometry; therapeutics
- Abstract:
- ... Rhubarb is a traditional Chinese medicine(TCM), that possesses neuroprotective, anti-inflammatory, antibacterial, antioxidative, purgative and anticancer properties, and has been used to treat intracerebral hemorrhage (ICH) and many other diseases.This study aimed to investigate the changes of brain protein in ICH rats treated with rhubarb and to explore the multi-target mechanism of rhubarb in th ...
- DOI:
- 10.1016/j.jep.2018.11.032
- https://doi.org/10.1016/j.jep.2018.11.032
- Author:
- Lan-Ying PAN; Kui ZENG; Li LI; Yan LOU; Su ZENG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.9 pp. 682-689
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Stellera chamaejasme; antineoplastic activity; antiviral agents; bioavailability; dogs; drugs; excretion; flavones; genes; humans; inhibitory concentration 50; kidneys; lamivudine; pharmacokinetics; physiological transport; plant extracts; rats; roots; transporters
- Abstract:
- ... Stellera chamaejasme L. is a traditional Chinese medicine with a long history to treat stubborn skin ulcer, and it also has antiviral and antitumor effects. Neochamaejasmine B (NCB), Neochamaejasmine A (NCA) and Chamaechromone (CMC) are the major components in dried roots of Stellera chamaejasme L.. Our studies suggested that NCB, NCA and CMC are inhibitors of Organic anion transporter 1 (OAT1). O ...
- DOI:
- 10.1016/S1875-5364(19)30082-2
- https://doi.org/10.1016/S1875-5364(19)30082-2
- Author:
- Quang‐Ung Le; Horng‐Liang Lay; Ming‐Chang Wu
- Source:
- Journal of food biochemistry 2019 v.43 no.2 pp. e12718
- ISSN:
- 0145-8884
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Cymbopogon flexuosus; Oriental traditional medicine; aerial parts; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; candy; caspase-3; caspase-9; chemical structure; cough; cytotoxicity; diet; ethanol; flavonoids; food industry; inhibitory concentration 50; liver; lung neoplasms; nuclear magnetic resonance spectroscopy; pharyngitis; secondary metabolites; skin diseases; spectral analysis; spices; Vietnam
- Abstract:
- ... This study investigated bioactive secondary metabolites from the aerial parts of Cymbopogon flexuosus (CF). Total phenolic and total flavonoid contents, the antioxidant activities including 2, 2′‐azino‐bis (3‐ethylbenzthiazoline‐6‐sulfonic acid) (ABTS⁺) and 2, 2′‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging systems, and cytotoxic effects were determined. 1, 3‐O‐di‐E‐caffeoylglycerol (SA3) a ...
- DOI:
- 10.1111/jfbc.12718
- https://doi.org/10.1111/jfbc.12718
- Author:
- Chaopan Zheng; Ling Han; Shihai Wu
- Source:
- Molecular biology reports 2019 v.46 no.4 pp. 3857-3864
- ISSN:
- 0301-4851
- Subject:
- Glycyrrhiza glabra; Oriental traditional medicine; alanine; antineoplastic activity; apoptosis; aspartic acid; biomarkers; biosynthesis; carcinoma; cell lines; cysteine; drugs; gas chromatography-mass spectrometry; glutamic acid; glutamine; glutathione; lipid metabolism; metabolites; metabolome; metabolomics; methionine; neoplasm cells; patients; serine; stearic acid; therapeutics; threonine
- Abstract:
- ... Although a majority of nasopharyngeal carcinoma (NPC) are undifferentiated and strongly radiosensitive, many NPC patients still have troubles in recurrence. Traditional Chinese medicine (TCM) is considered as potential therapeutic drugs in NPC. However, the effect of Glycyrrhiza glabra on NPC is limited. The present study shows the decreased proliferation and high apoptosis in G. glabra root extra ...
- DOI:
- 10.1007/s11033-019-04828-1
- https://doi.org/10.1007/s11033-019-04828-1
- Author:
- Zhaoyu Fu; Kexin Ma; Bing Dong; Chongyu Zhao; Chi Che; Chengyong Dong; Rixin Zhang; Haibo Wang; Xiang Wang; Rui Liang
- Source:
- BMC complementary and alternative medicine 2019 v.19 no.1 pp. 203
- ISSN:
- 1472-6882
- Subject:
- Oriental traditional medicine; Western blotting; alternative medicine; antagonism; antineoplastic activity; apoptosis; cell cycle checkpoints; cell movement; cell proliferation; cyclins; drug therapy; flow cytometry; fluorouracil; genes; humans; metastasis; migratory behavior; patients; phenotype; tissue repair
- Abstract:
- ... BACKGROUND: 5-Florouracil (5-FU) is a commonly used chemotherapeutic drug for cholangiocarcinoma, whereas it has unsatisfactory effect, and patients often have chemo-resistance to it. The combination of chemotherapeutic agents and traditional Chinese medicine has already exhibited a promising application in oncotherapy. Huaier extract (Huaier) has been used in clinical practice widely, exhibiting ...
- DOI:
- 10.1186/s12906-019-2614-5
- PubMed:
- 31391034
- PubMed Central:
- PMC6686517
- https://doi.org/10.1186/s12906-019-2614-5