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- Author:
- Fu-Zhen Lin; Shih-Chung Wang; Yi-Ting Hsi; Yu-Sheng Lo; Chia-Chieh Lin; Yi-Ching Chuang; Shu-Hui Lin; Ming-Ju Hsieh; Mu-Kuan Chen
- Source:
- Phytomedicine 2019 v.54 pp. 1-8
- ISSN:
- 0944-7113
- Subject:
- Oriental traditional medicine; apoptosis; caspase-3; caspase-8; caspase-9; cell cycle checkpoints; cell lines; drug therapy; herbal medicines; mortality; mouth neoplasms; multiple drug resistance; neoplasm cells; patients; proteins; signal transduction; surgery; triterpenoids; vincristine; Asia
- Abstract:
- ... Oral cancers are one of the most aggressive malignancies, with high mortality rates globally. Patients with these cancers are treated using combination therapies including surgery, chemotherapy, and radiotherapy.Traditional Chinese medicines and other herbal medicines have been used to treat various diseases in Asia. Celastrol is a pentacyclic triterpenoid isolated from the Chinese herbal medicine ...
- DOI:
- 10.1016/j.phymed.2018.09.181
- https://doi.org/10.1016/j.phymed.2018.09.181
- Author:
- Qing Zhao; Xia Ren; Min Chen; Shi-Jun Yue; Meng-Qi Zhang; Kai-Xian Chen; Yue-Wei Guo; Chang-Lun Shao; Chang-Yun Wang
- Source:
- Journal of ethnopharmacology 2019 v.244 pp. 112132
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; alanine transaminase; aspartate transaminase; biomarkers; cell lines; ducks; hepatitis B; hepatitis B antigens; histology; histopathology; in vitro studies; liver; models; poultry diseases; secretion; China
- Abstract:
- ... Formula Le-Cao-Shi (LCS) is a traditional Chinese medicine (TCM), which has long been used as a folk remedy against hepatitis B in China. The present study was conducted to evaluate the anti-hepatitis B effects of aqueous extract of LCS in vivo and in vitro.we investigated the anti-HBV effects of LCS in vivo and in vitro with duck hepatitis B model and HepG2.2.15 cell line model, respectively. The ...
- DOI:
- 10.1016/j.jep.2019.112132
- https://doi.org/10.1016/j.jep.2019.112132
- Author:
- Cheng-Yao MA; Jia-Hui LU; Xiang LI; Xiao LIU; Jian-Wei CHEN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.4 pp. 291-297
- ISSN:
- 1875-5364
- Subject:
- Annona squamosa; Oriental traditional medicine; acetogenins; cell lines; cytotoxicity; multiple drug resistance; seeds; spectral analysis
- Abstract:
- ... Eight new annonaceous acetogenins, squamotin A-D (1–4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compoun ...
- DOI:
- 10.1016/S1875-5364(19)30032-9
- https://doi.org/10.1016/S1875-5364(19)30032-9
- Author:
- Hongqing Xie; Xiaotong Li; Yajie Chen; Mingzi Lang; Zhangfei Shen; Liangen Shi
- Source:
- Journal of ethnopharmacology 2019 v.231 pp. 230-240
- ISSN:
- 0378-8741
- Subject:
- Cordyceps; Oriental traditional medicine; Western blotting; adenine; adenosine; antineoplastic activity; antineoplastic agents; apoptosis; calcium; caspase-12; caspase-3; caspase-6; caspase-8; caspase-9; cell cycle checkpoints; cell lines; cyclin-dependent kinase; cyclins; cytochrome c; cytosol; dose response; endoplasmic reticulum; endoplasmic reticulum stress; flow cytometry; fluorescent dyes; high performance liquid chromatography; humans; interphase; membrane potential; mitochondria; mitochondrial membrane; neoplasm cells; staining; stomach neoplasms; therapeutics; toxicity; toxicity testing; uridine
- Abstract:
- ... Cordyceps cicadae (Miq.) Massee is a traditional Chinese medicine that has been used for approximately 1600 years in China. C. cicadae, a member of the Cordyceps genus, exerts a therapeutic effect on many diseases, such as cancer.This study aimed to evaluate the antineoplasmic activity of C. cicadae and to identify its molecular mechanism of cell death.The toxicity of the ethanolic extract of C. c ...
- DOI:
- 10.1016/j.jep.2018.11.028
- https://doi.org/10.1016/j.jep.2018.11.028
- Author:
- Zheng LI; Qian-Qian CHEN; Christopher Wai Kei LAM; Jian-Ru GUO; Wei-Jia ZHANG; Cai-Yun WANG; Vincent Kam Wai WONG; Mei-Cun YAO; Wei ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 608-615
- ISSN:
- 1875-5364
- Subject:
- DNA replication; Oriental traditional medicine; adenocarcinoma; antineoplastic activity; cell cycle checkpoints; cell lines; cytotoxicity; epithelial cells; humans; hydroxyurea; interphase; liquid chromatography; lungs; mass spectrometry; metabolism; metabolomics; nucleosides; resveratrol
- Abstract:
- ... In an effort to understand the molecular events contributing to the cytotoxicity activity of resveratrol (RSV), we investigated its effects on human lung adenocarcinoma epithelial cell line A549 at different concentrations. Cellular nucleoside metabolic profiling was determined by an established liquid chromatography-mass spectrometry method in A549 cells. RSV resulted in significant decreases and ...
- DOI:
- 10.1016/S1875-5364(19)30063-9
- https://doi.org/10.1016/S1875-5364(19)30063-9
- Author:
- Qi Hu; Yusi Bu; Ruiqi Cao; Gao Zhang; Xiaoyu Xie; Sicen Wang
- Source:
- Analytical chemistry 2019 v.91 no.20 pp. 13062-13070
- ISSN:
- 1520-6882
- Subject:
- Aconitum carmichaelii; Oriental traditional medicine; binding capacity; biomimetics; carbon nanotubes; cell growth; cell lines; cell membranes; longevity; magnetism; neoplasm cells; neoplasms; receptors; screening
- Abstract:
- ... Convenient strategies to provide natural cell membranes (CMs)-camouflaged nanomaterials with enhanced stability would prompt the advancement of CMs-coated biomimetic technology and expand the application of these emerging nanomaterials. Herein, we have developed stability-enhanced CMs-camouflaged magnetic carbon nanotubes (MCNTs) to screen drug leads from traditional Chinese medicine (TCMs) that t ...
- DOI:
- 10.1021/acs.analchem.9b03268
- https://doi.org/10.1021/acs.analchem.9b03268
- Author:
- Peng-Cheng LIN; Lin-Lin JI; Xiang-Jian ZHONG; Jin-Jie LI; Xin WANG; Xiao-Ya SHANG; Sheng LIN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.1 pp. 22-26
- ISSN:
- 1875-5364
- Subject:
- Cirsium arvense; Oriental traditional medicine; animal ovaries; antineoplastic activity; cell lines; chemical structure; colorectal neoplasms; cytotoxicity; food plants; humans; inhibitory concentration 50; ovarian neoplasms; secretion; spectral analysis; triterpenoids; tumor necrosis factor-alpha
- Abstract:
- ... Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD d ...
- DOI:
- 10.1016/S1875-5364(19)30005-6
- https://doi.org/10.1016/S1875-5364(19)30005-6
- Author:
- Yi Jing; Hai-Jiang Zhang; Kui-Wu Wang; Xiao-Xin Wang; Ming-Long Chen; Hong Wang; Bin Wu
- Source:
- Phytochemistry letters 2019 v.29 pp. 134-137
- ISSN:
- 1874-3900
- Subject:
- Hedyotis; Oriental traditional medicine; anthraquinones; cell lines; chemotaxonomy; cytotoxicity; inhibitory concentration 50; neoplasm cells; nuclear magnetic resonance spectroscopy; physicochemical properties
- Abstract:
- ... Seven anthraquinones, including two new natural products, hedyanthraquinones A and B (1, 2), were isolated from Hedyotis caudatifolia. The structures were elucidated based on NMR, MS data and physico-chemical properties. Compounds 1 and 2 displayed moderate cytotoxic activities against a panel of cultured tumor cell lines (HL-60, Bcap37, SMMC7721) with IC50 values of 13.71 ∼ 26.29 μM. The result s ...
- DOI:
- 10.1016/j.phytol.2018.11.026
- https://doi.org/10.1016/j.phytol.2018.11.026
- Author:
- Wen-Long Wei; Jin-Jun Hou; Xia Wang; Yang Yu; Hao-Jv Li; Zhen-Wei Li; Zi-Jin Feng; Hua Qu; Wan-Ying Wu; De-An Guo
- Source:
- Journal of ethnopharmacology 2019 v.237 pp. 215-235
- ISSN:
- 0378-8741
- Subject:
- Bufo; Oriental traditional medicine; adverse effects; anesthetics; animals; antimicrobial properties; antineoplastic activity; bioavailability; biochemical pathways; bufadienolides; cardiotoxicity; cell lines; clinical trials; databases; diarrhea; heat stroke; hydroxylation; indole alkaloids; metabolites; neoplasm cells; neoplasms; new drugs; pain; pharmacodynamics; pharmacokinetics; secretion; toxicology; vomiting
- Abstract:
- ... The animal medicine of Venenum Bufonis (VB), a product of the secretions of Bufo gargarizans Cantor or B. melanostictus Schneider, has long been used as a traditional Chinese medicine (TCM) for the treatment of sunstroke and faint, acute filthy disease - abdominal pain or vomiting and diarrhea, etc.This review is aimed at providing the comprehensive and up-to-date information of VB as regards its ...
- DOI:
- 10.1016/j.jep.2019.03.042
- https://doi.org/10.1016/j.jep.2019.03.042
- Author:
- Yun Huang; Kenneth Kin Leung Kwan; Ka Wing Leung; Ping Yao; Huaiyou Wang; Tina Tingxia Dong; Karl Wah Keung Tsim
- Source:
- Journal of Ginseng Research 2019 v.43 no.4 pp. 517-526
- ISSN:
- 1226-8453
- Subject:
- Oriental traditional medicine; Panax ginseng; cardiomyocytes; cell lines; energy metabolism; ethanol; functional foods; herbal medicines; mitochondria; oxidative stress; oxygen consumption; rats; research; Asia
- Abstract:
- ... The root of Panax ginseng, a member of Araliaceae family, has been used as herbal medicine and functional food in Asia for thousands of years. According to Traditional Chinese medicine, ginseng is the most widely used “Qi-invigorating” herbs, which provides tonic and preventive effects by resisting oxidative stress, influencing energy metabolism, and improving mitochondrial function. Very few repo ...
- DOI:
- 10.1016/j.jgr.2018.02.002
- https://doi.org/10.1016/j.jgr.2018.02.002
- Author:
- Qing Lin; Mengke Qu; Hirak K. Patra; Shanshan He; Luyao Wang; Xun Hu; Linyu Xiao; Yu Fu; Tao Gong; Qin He; Ling Zhang; Xun Sun; Zhirong Zhang
- Source:
- Journal of ethnopharmacology 2019 pp. -
- ISSN:
- 0378-8741
- Subject:
- Fritillaria cirrhosa; Oriental traditional medicine; Western blotting; active ingredients; adverse effects; animal models; antineoplastic activity; antineoplastic agents; blood cell counts; cancer therapy; case studies; cell lines; cytotoxicity; drug delivery systems; enzyme-linked immunosorbent assay; films (materials); herbal medicines; histopathology; immunohistochemistry; in vivo studies; inflammation; lung neoplasms; mice; transcription factor NF-kappa B
- Abstract:
- ... Bulbus Fritillaria cirrhosa D. Don (BFC) is a Chinese traditional herbal medicine that has long been used as an indispensable component in herbal prescriptions for bronchopulmonary diseases due to its well-established strong anti-inflammation and pulmonary harmonizing effects. Interestingly, there are few case reports in traditional Chinese medicine available where they found it to contribute in a ...
- DOI:
- 10.1016/j.jep.2019.112283
- https://doi.org/10.1016/j.jep.2019.112283
- Author:
- Ping Song; Hao Chen; Yun Huang; Yanzhang Wen; Ji Hao; Yibing Lv; Shihao Deng; Xinzhou Yang
- Source:
- Chemistry of natural compounds 2019 v.55 no.5 pp. 835-838
- ISSN:
- 0009-3130
- Subject:
- Oriental traditional medicine; Sophora alopecuroides; anticarcinogenic activity; cell lines; cytotoxicity; ethyl acetate; hepatoma; nuclear magnetic resonance spectroscopy; phenolic acids; seeds; spectral analysis
- Abstract:
- ... Chemical profiling of the EtOAc extract from a traditional Chinese medicine Sophora alopecuroides yielded a new phenolic acid, (3S,2R)-methyl 2-(4-hydroxybenzyl)tartrate (1), along with four known compounds, eucomic acid (2), methyl eucomate (3), piscidic acid (4), and ethyl 2-(4-hydroxybenzyl)tartrate (5). The structure of 1 was determined by extensive spectral analyses including 1D and 2D NMR an ...
- DOI:
- 10.1007/s10600-019-02826-0
- https://doi.org/10.1007/s10600-019-02826-0
- Author:
- Kok-Tong Tan; Shiming Li; Yi Rong Li; Shih-Lung Cheng; Sheng-Hao Lin; Yu-Tang Tung
- Source:
- Applied biochemistry and biotechnology 2019 v.187 no.4 pp. 1328-1343
- ISSN:
- 0273-2289
- Subject:
- Oriental traditional medicine; active ingredients; adverse effects; antineoplastic activity; antineoplastic agents; apoptosis; caspase-3; caspase-8; caspase-9; cell lines; cell viability; drug synergism; drug therapy; flavones; herbs; lung neoplasms; mice; models; neoplasm cells; orange peels; paclitaxel; propidium
- Abstract:
- ... Lung cancer remains a highly prevalent disease and a leading cause of cancer-related deaths worldwide. Currently, exploring antitumor drugs derived from herbs used in traditional Chinese medicine is increasingly becoming an attractive area of research. Paclitaxel (PTX), a highly effective chemotherapeutic drug, is widely used for treating different cancers; however, the clinical use of PTX is dose ...
- DOI:
- 10.1007/s12010-018-2869-1
- https://doi.org/10.1007/s12010-018-2869-1
- Author:
- Meng-Yao SUN; Dan-Dan WANG; Jian SUN; Xiao-Hua ZHAO; Si CAI; Qiu-Xue WU; Tao JIE; Zhen-Hua NI; Jian-Yue SUN; Qing-Feng TANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.3 pp. 198-208
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Western blotting; apoptosis; cell lines; cell proliferation; cisplatin; drug therapy; flow cytometry; humans; mitochondria; models; neoplasm cells; patients; protein synthesis; staining; stomach neoplasms
- Abstract:
- ... Resistance to cisplatin (DDP)-based chemotherapy is a major cause of treatment failure in human gastric cancer (GC). It is necessary to identify the drugs to re-sensitize GC cells to DDP. In our previous research, Zuo Jin Wan Formula (ZJW) has been proved could increase the mitochondrial apoptosis via cofilin-1 in a immortalized cell line, SGC-7901/DDP. Due to the immortalized cells may still diff ...
- DOI:
- 10.1016/S1875-5364(19)30022-6
- https://doi.org/10.1016/S1875-5364(19)30022-6
- Author:
- Chaopan Zheng; Ling Han; Shihai Wu
- Source:
- Molecular biology reports 2019 v.46 no.4 pp. 3857-3864
- ISSN:
- 0301-4851
- Subject:
- Glycyrrhiza glabra; Oriental traditional medicine; alanine; antineoplastic activity; apoptosis; aspartic acid; biomarkers; biosynthesis; carcinoma; cell lines; cysteine; drugs; gas chromatography-mass spectrometry; glutamic acid; glutamine; glutathione; lipid metabolism; metabolites; metabolome; metabolomics; methionine; neoplasm cells; patients; serine; stearic acid; therapeutics; threonine
- Abstract:
- ... Although a majority of nasopharyngeal carcinoma (NPC) are undifferentiated and strongly radiosensitive, many NPC patients still have troubles in recurrence. Traditional Chinese medicine (TCM) is considered as potential therapeutic drugs in NPC. However, the effect of Glycyrrhiza glabra on NPC is limited. The present study shows the decreased proliferation and high apoptosis in G. glabra root extra ...
- DOI:
- 10.1007/s11033-019-04828-1
- https://doi.org/10.1007/s11033-019-04828-1