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You searched for: Publication Year 2019 Remove constraint Publication Year: 2019 Subject animal ovaries Remove constraint Subject: animal ovaries Subject antineoplastic activity Remove constraint Subject: antineoplastic activity
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1. Carboplatin prodrug conjugated Fe₃O₄ nanoparticles for magnetically targeted drug delivery in ovarian cancer cells

Author:
Haiqin SongThe two authors contributed equally to this work.; Feifei Quan; Zhiqiang Yu; Minhua Zheng; Yan Ma; Haihua Xiao; Fang Ding
Source:
Journal of materials chemistry B 2019 v.7 no.3 pp. 433-442
ISSN:
2050-7518
Subject:
adverse effects; animal ovaries; antineoplastic activity; cell lines; chemistry; cisplatin; cytotoxicity; drug resistance; endocytosis; in vivo studies; iron oxides; magnetic fields; nanocarriers; nanoparticles; neoplasm cells; ovarian neoplasms; platinum; toxicity testing; zeta potential
Abstract:
... Platinum (Pt)-based drugs including cisplatin, carboplatin and oxaliplatin have been widely used as first-line anticancer regimens due to their excellent anticancer efficacy. However, the clinical application of these drugs is greatly limited due to their side effects and drug resistance. In this study, an antitumor drug delivery system based on carboplatin prodrug loading Fe₃O₄ nanoparticles (NPs ...
DOI:
10.1039/c8tb02574f

2. Comprehensive review on how platinum- and taxane-based chemotherapy of ovarian cancer affects biology of normal cells

Author:
Justyna Mikuła-Pietrasik; Anna Witucka; Martyna Pakuła; Paweł Uruski; Beata Begier-Krasińska; Arkadiusz Niklas; Andrzej Tykarski; Krzysztof Książek
Source:
Cellular and molecular life sciences 2019 v.76 no.4 pp. 681-697
ISSN:
1420-682X
Subject:
DNA damage; angiogenesis; animal ovaries; antineoplastic activity; apoptosis; cell senescence; drug therapy; drugs; endothelial cells; epithelial cells; fibroblasts; metabolism; mitophagy; neurons; ovarian neoplasms; oxidative stress; somatic cells
Abstract:
... One of the most neglected aspects of chemotherapy are changes, and possible consequences of these changes, that occur in normal somatic cells. In this review, we summarize effects of selected drugs used to treat ovarian cancer (platin derivatives—cisplatin and carboplatin; and taxanes—paclitaxel and docetaxel) on cellular metabolism, acquisition of reactive stroma features, cellular senescence, in ...
DOI:
10.1007/s00018-018-2954-1
PubMed:
30382284
PubMed Central:
PMC6514066

3. Investigation of anti-cancer and migrastatic properties of novel curcumin derivatives on breast and ovarian cancer cell lines

Author:
Jinsha Koroth; Snehal Nirgude; Shweta Tiwari; Vidya Gopalakrishnan; Raghunandan Mahadeva; Sujeet Kumar; Subhas S. Karki; Bibha Choudhary
Source:
BMC complementary and alternative medicine 2019 v.19 no.1 pp. 273
ISSN:
1472-6882
Subject:
Western blotting; adverse effects; alternative medicine; animal ovaries; antineoplastic activity; apoptosis; bioavailability; breast neoplasms; cell lines; cell movement; curcumin; cytotoxicity; flow cytometry; interstitial collagenase; liquids; metastasis; neoplasm cells; ovarian neoplasms; stem cells; toxicity testing
Abstract:
... BACKGROUND: Curcumin is known for its multitude of medicinal properties, including anti-cancer and migrastatic activity. Efforts to overcome poor bioavailability, stability, and side effects associated with the higher dose of curcumin has led to the development of newer derivatives of curcumin. Thus, the focus of this study is to screen novel curcumin derivatives, namely ST03 and ST08, which have ...
DOI:
10.1186/s12906-019-2685-3
PubMed:
31638975
PubMed Central:
PMC6802352

4. PDZ and LIM domain protein 4 suppresses the growth and invasion of ovarian cancer cells via inactivation of STAT3 signaling

Author:
Yanyan Jia; Huirong Shi; Yuan Cao; Wenlong Feng; Meijuan Li; Xueru Li
Source:
Life sciences 2019 v.233 pp. 116715
ISSN:
0024-3205
Subject:
animal ovaries; antineoplastic activity; carcinogenesis; cell growth; gene overexpression; lymph nodes; metastasis; neoplasm cells; ovarian neoplasms; patients; phosphorylation; prognosis; therapeutics; tissues; transcriptional activation
Abstract:
... PDZ and LIM domain protein 4 (PDLIM4) is frequently repressed in cancer tissues. However, the expression and role of PDLIM4 in ovarian cancer has not been addressed.In this study, we examined the expression and prognostic significance of PDLIM4 in ovarian cancer. The function of PDLIM4 in ovarian cancer cell growth, invasion, and tumorigenesis was further explored.PDLIM4 is downregulated in ovaria ...
DOI:
10.1016/j.lfs.2019.116715

5. Plumbagin from a tropical pitcher plant (Nepenthes alata Blanco) induces apoptotic cell death via a p53-dependent pathway in MCF-7 human breast cancer cells

Author:
Umasankar De; Ji Yeon Son; Yukyoung Jeon; Song-Yi Ha; Yu Jin Park; Sungpil Yoon; Ki-Tae Ha; Wahn Soo Choi; Byung Mu Lee; In Su Kim; Jong Hwan Kwak; Hyung Sik Kim
Source:
Food and chemical toxicology 2019 v.123 pp. 492-500
ISSN:
0278-6915
Subject:
Nepenthes alata; adverse effects; animal models; animal ovaries; antineoplastic activity; apoptosis; breast neoplasms; cell cycle checkpoints; cyclins; cysteine; cytochrome c; cytotoxicity; epithelium; humans; mice; neoplasm cells; ovarian neoplasms; plumbagin; reactive oxygen species; therapeutics
Abstract:
... Plumbagin (5-hydroxy-2-methyl-1,4-naphthaquinone) has displayed antitumor activity in vitro and in animal models; however, the underlying molecular mechanisms have not been fully explored. The aim of this study was to investigate the anticancer effects of plumbagin isolated from Nepenthes alata against MCF-7 breast cancer cells. We examined the cytotoxicity, cell cycle regulation, apoptotic cell d ...
DOI:
10.1016/j.fct.2018.11.040

6. Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum

Author:
Peng-Cheng LIN; Lin-Lin JI; Xiang-Jian ZHONG; Jin-Jie LI; Xin WANG; Xiao-Ya SHANG; Sheng LIN
Source:
Chinese journal of natural medicines 2019 v.17 no.1 pp. 22-26
ISSN:
1875-5364
Subject:
Cirsium arvense; Oriental traditional medicine; animal ovaries; antineoplastic activity; cell lines; chemical structure; colorectal neoplasms; cytotoxicity; food plants; humans; inhibitory concentration 50; ovarian neoplasms; secretion; spectral analysis; triterpenoids; tumor necrosis factor-alpha
Abstract:
... Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD d ...
DOI:
10.1016/S1875-5364(19)30005-6

7. Transcriptome analysis reveals that cyclophosphamide induces premature ovarian failure by blocking cholesterol biosynthesis pathway

Author:
Qi Li; Xinglan An; Xiaxia Man; Meiran Chu; Tianchuang Zhao; Hao Yu; Ziyi Li
Source:
Life sciences 2019 v.239 pp. 116999
ISSN:
0024-3205
Subject:
adverse effects; animal ovaries; antineoplastic activity; biosynthesis; blood serum; cholesterol; cyclophosphamide; enzyme-linked immunosorbent assay; eosin; estradiol; follicle-stimulating hormone; gene expression regulation; genes; intraperitoneal injection; mice; peroxisome proliferator-activated receptors; protein-protein interactions; quantitative polymerase chain reaction; sequence analysis; signal transduction; staining; toxicity; transcriptome; transcriptomics
Abstract:
... The present study aimed to investigate the effects of cyclophosphamide (Cytoxan, CTX) on premature ovarian failure (POF) in mice and its regulatory mechanisms by transcriptome analysis.Female C57BL/6 mice were treated with a single intraperitoneal injection of 70 mg/kg CTX. Serum levels of estradiol (E₂) and follicle stimulating hormone (FSH) were measured by enzyme-linked immunosorbent assay (ELI ...
DOI:
10.1016/j.lfs.2019.116999