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You searched for: Publication Year 2019 Remove constraint Publication Year: 2019 Subject antineoplastic activity Remove constraint Subject: antineoplastic activity Subject antineoplastic agents Remove constraint Subject: antineoplastic agents Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. 2′-Hydroxyflavanone induced changes in the proteomic profile of breast cancer cells

Author:
Lokesh D. Nagaprashantha; Jyotsana Singhal; Shireen Chikara; Gabriel Gugiu; David Horne; Sanjay Awasthi; Ravi Salgia; Sharad S. Singhal
Source:
Journal of proteomics 2019 v.192 pp. 233-245
ISSN:
1874-3919
Subject:
antineoplastic activity; antineoplastic agents; breast neoplasms; breasts; citrus fruits; epithelial cells; flavonoids; metastasis; neoplasm cells; proteins; proteomics; therapeutics; women
Abstract:
... In spite of rapid advances in understanding of signaling networks associated with the incidence and therapeutic-sensitivity, breast cancer (BC) still remains the most commonly diagnosed and prevalent cancer in women. Emergence of resistance to hormonal interventions in estrogen-receptor (ER) positive BC coupled to loss of ER expression and activation of ER-independent growth factor, heat-shock, MY ...
DOI:
10.1016/j.jprot.2018.09.005

2. 4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer

Author:
Zhicong Zhao; Dongsheng Shang; Lipeng Qiu; Chang Guo; Yanyan Li; Hanqing Liu; Guoyue Yuan; Zhigang Tu
Source:
Life sciences 2019 v.238 pp. 116973
ISSN:
0024-3205
Subject:
DNA damage; antineoplastic activity; antineoplastic agents; cell senescence; drug therapy; enzymes; fluorescent antibody technique; heterocyclic nitrogen compounds; in vitro studies; in vivo studies; mice; screening; signal transduction; staining; stomach neoplasms; survival rate
Abstract:
... Gastric cancer (GC) is a common cancer with a relatively low survival rate. Cellular senescence, a potent anti-cancer mechanism, is naturally occurred, and can be induced by chemotherapeutic agents. We sought to explore new compounds against GC cells by inducing cellular senescence.Primary screening of a library of N-heterocyclic compounds identified some with potent inhibitory effects on GC cells ...
DOI:
10.1016/j.lfs.2019.116973

3. 5-Acetamido-1-(methoxybenzyl) isatin inhibits tumor cell proliferation, migration, and angiogenesis

Author:
Qian Zhang; Ying Fu; Yufan Zhao; Shanshan Cui; Jing Wang; Fengxi Liu; Yuan Yuan; Hervé Galons; Peng Yu; Yuou Teng
Source:
RSC advances 2019 v.9 no.63 pp. 36690-36698
ISSN:
2046-2069
Subject:
angiogenesis; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cell proliferation; chemotaxis; cyclins; flow cytometry; human umbilical vein endothelial cells; humans; indoles; liver neoplasms; mitochondria; neoplasm cells
Abstract:
... Indole and its derivatives are widely distributed in both animals and plants. Among its array of biological activities, the anti-tumor activity of indole has garnered much attention. Furthermore, the synthesis and activity of indole derivatives, including isatin, constitute a flourishing research topic. Previously, many isatin derivatives were synthesized by our group, and 5-acetamido-1-(methoxybe ...
DOI:
10.1039/c9ra07002h

4. Allium vegetables for possible future of cancer treatment

Author:
Yahya Asemani; Nasrindokht Zamani; Maryam Bayat; Zahra Amirghofran
Source:
Phytotherapy research 2019 v.33 no.12 pp. 3019-3039
ISSN:
0951-418X
Subject:
Allium; adverse effects; ajoene; antineoplastic activity; antineoplastic agents; antioxidant activity; apoptosis; cell cycle; chives; garlic; health effects assessments; ingredients; leeks; medicinal plants; metastasis; neoplasm cells; neoplasms; quercetin; shallots; signal transduction; sulfur; therapeutics; traditional medicine
Abstract:
... Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, onions, leeks, chives, and shallots. These plants have been exploited in folk medicine because of their beneficial health effects in improving numerou ...
DOI:
10.1002/ptr.6490

5. Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from Foeniculum vulgare from Hamedan, Iran

Author:
Maryam Akhbari; Reza Kord; Saeedeh Jafari Nodooshan; Sepideh Hamedi
Source:
Natural product research 2019 v.33 no.11 pp. 1629-1632
ISSN:
1478-6427
Subject:
Artemia; Escherichia coli; Foeniculum vulgare; Pseudomonas aeruginosa; Shigella dysenteriae; antibacterial properties; antineoplastic activity; antineoplastic agents; breast neoplasms; carcinoma; cell lines; death; essential oils; gas chromatography-mass spectrometry; humans; inhibitory concentration 50; lethal concentration 50; limonene; methyl chavicol; seed oils; seeds; toxicity; Iran
Abstract:
... In this study, biological properties of the essential oil isolated from seeds of Foeniculum vulgare (F. vulgare) were evaluated. GC-MS analysis revealed Trans-Anethole (80.63%), L-Fenchone (11.57%), Estragole (3.67%) and Limonene (2.68%) were the major compounds of the essential oil. Antibacterial activity of the essential oil against nine Gram-positive and Gram-negative strains was studied using ...
DOI:
10.1080/14786419.2017.1423310

6. Anti-cancer activities of cytokinin ribosides

Author:
Jiří Voller; Tibor Béres; Marek Zatloukal; Petr Džubák; Marián Hajdúch; Karel Doležal; Thomas Schmülling; Strnad Miroslav
Source:
Phytochemistry reviews 2019 v.18 no.4 pp. 1101-1113
ISSN:
1568-7767
Subject:
antineoplastic activity; antineoplastic agents; apoptosis; cell lines; cytokinins; genes; growth and development; immune response; in vivo studies; mutants; neoplasms; patients; plant development; plant growth; plant hormones; stem cells
Abstract:
... Cytokinins are plant hormones and play essential roles in regulating plant growth and development. They also have diverse pharmacological effects in animals and humans. Whereas cytokinin bases have been studied mainly for their cytoprotective activities, cytokinin ribosides have been explored as anti-cancer agents. Cytokinin ribosides inhibit growth or cause apoptosis in various cell lines derived ...
DOI:
10.1007/s11101-019-09620-4

7. Anti-cancer effect of Indanone-based thiazolyl hydrazone derivative on colon cancer cell lines

Author:
Silpa Narayanan; Pranav Gupta; Urooj Nazim; Mohsin Ali; Nishant Karadkhelkar; Mansoor Ahmad; Zhe-Sheng Chen
Source:
international journal of biochemistry & cell biology 2019 v.110 pp. 21-28
ISSN:
1357-2725
Subject:
DNA topoisomerase; antineoplastic activity; antineoplastic agents; apoptosis; biphenyl; cell lines; colorectal neoplasms; hydrazine; hydrazones; indans; inhibitory concentration 50; mitosis; neoplasm cells; patients; polymerization; toxicity; tubulin; United States
Abstract:
... Colorectal cancer is the third leading cause of cancer related deaths in the United States. Currently, Irinotecan, a topoisomerase I inhibitor, is an approved anti-cancer drug for the treatment of patients with advanced or recurrent colorectal cancer. Considering low response rate and events of high toxicity caused by irinotecan, we evaluated a series of thirteen thiazolyl hydrazone derivatives of ...
DOI:
10.1016/j.biocel.2019.02.004

8. Anti-lung cancer activity and inhibitory mechanisms of a novel Calothrixin A derivative

Author:
Xiaohong Yang; Jiangsheng Gao; Jian Guo; Zimeng Zhao; Shao-Lin Zhang; Yun He
Source:
Life sciences 2019 v.219 pp. 20-30
ISSN:
0024-3205
Subject:
DNA topoisomerase; antineoplastic activity; antineoplastic agents; apoptosis; autophagy; caspases; cell cycle checkpoints; cell movement; cytochrome c; cytotoxicity; humans; inhibitory concentration 50; interphase; mitochondria; mitogen-activated protein kinase; models; neoplasm cells; neoplasms; plasmids
Abstract:
... CAA45 is a calothrixin A (CAA) analogue with anti-cancer activity at nanomolar concentration. This study aimed to investigate the anti-lung cancer activity of CAA45 and explore its mechanisms of actions.CAA and CAA45 were synthesized and their inhibition on DNA topoisomerase I (Topo I) performed by evaluating the relaxation of supercoiled pBR322 plasmid DNA and their anti-lung cancer capacity dete ...
DOI:
10.1016/j.lfs.2018.12.052

9. Anti-tumor properties of methoxylated analogues of resveratrol in malignant MCF-7 but not in non-tumorigenic MCF-10A mammary epithelial cell lines

Author:
Annick D. van den Brand; Judith Villevoye; Sandra M. Nijmeijer; Martin van den Berg; Majorie B.M. van Duursen
Source:
Toxicology 2019 v.422 pp. 35-43
ISSN:
0300-483X
Subject:
antineoplastic activity; antineoplastic agents; breast neoplasms; breasts; cell cycle checkpoints; cell lines; cell viability; cytochrome P-450; epithelial cells; gene expression; humans; hydroxylation; interleukin-8; mammary glands; median effective concentration; models; neoplasm cells; polyphenols; pterostilbene; reporter genes; resveratrol
Abstract:
... Resveratrol is a plant-derived polyphenol that is known for its anti-inflammatory and anti-tumorigenic properties in in vitro and in vivo models. Recent studies show that some resveratrol analogues might be more potent anti-tumor agents, which may partly be attributed to their ability to activate the aryl hydrocarbon receptor (AHR). Here, the anti-tumorigenic properties of resveratrol and structur ...
DOI:
10.1016/j.tox.2019.04.009

10. Anticancer activity of a novel glycoprotein from Camellia oleifera Abel seeds against hepatic carcinoma in vitro and in vivo

Author:
Tingting Li; Xiangyong Meng; Caie Wu; Gongjian Fan; Jing Yang; Wenting Pan
Source:
International journal of biological macromolecules 2019 v.136 pp. 284-295
ISSN:
0141-8130
Subject:
Camellia oleifera; T-lymphocytes; Western blotting; antineoplastic activity; antineoplastic agents; apoptosis; carcinoma; caspase-3; cell cycle checkpoints; chromatography; electron microscopy; flow cytometry; fluorescence microscopy; glycoproteins; human cell lines; interferon-gamma; membrane potential; mice; mitochondrial membrane; molecular weight; pancreas; pro-apoptotic proteins; seeds; thymus gland; toxicity testing
Abstract:
... Glycoproteins are naturally occurring biological macromolecule that possess known pharmacological properties. This study investigated the anticancer potential of a new glycoprotein, COG2a with the weight-average molecular weight of 25.9 kDa, isolated from Camellia oleifera Abel seeds by multiple column chromatography and the mechanism of anticancer action. MTT assay showed that the maximum inhibit ...
DOI:
10.1016/j.ijbiomac.2019.06.054

11. Anticancer activity of polymeric nanoparticles containing linoleic acid-SN38 (LA-SN38) conjugate in a murine model of colorectal cancer

Author:
Guilin Cheng; Xiaomin Zhang; Yidan Chen; Robert J. Lee; Jiangfeng Wang; Ju Yao; Yingxin Zhang; Cheng Zhang; Kaifeng Wang; Bo Yu
Source:
Colloids and surfaces 2019 v.181 pp. 822-829
ISSN:
0927-7765
Subject:
animal models; antineoplastic activity; antineoplastic agents; apoptosis; biodegradability; blood circulation; colorectal neoplasms; composite polymers; cytotoxicity; humans; in vitro studies; linoleic acid; macrophages; nanocarriers; nanoparticles; neoplasm cells; phagocytosis; polyethylene glycol; single nucleotide polymorphism; solvents; tetrahydrofuran; titration; transmission electron microscopes; transmission electron microscopy
Abstract:
... Biodegradable polymeric nanoparticles (NPs) have been used frequently as nanocarriers for anticancer drugs. Linoleic acid conjugated SN38 (LA-SN38)-loaded NPs (EBNPs) were developed using biodegradable poly (ethylene oxide)-poly (butylene oxide) (PEO-PBO) diblock copolymer by titration hydration method without using a toxic organic solvent. The EBNPs had high drug loading efficiency and entrapment ...
DOI:
10.1016/j.colsurfb.2019.06.020

12. Anticancer properties of erucin, an H2S‐releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC‐1)

Author:
Valentina Citi; Eugenia Piragine; Eleonora Pagnotta; Luisa Ugolini; Lorenzo Di Cesare Mannelli; Lara Testai; Carla Ghelardini; Luca Lazzeri; Vincenzo Calderone; Alma Martelli
Source:
Phytotherapy research 2019 v.33 no.3 pp. 845-855
ISSN:
0951-418X
Subject:
Eruca vesicaria subsp. sativa; antineoplastic activity; antineoplastic agents; apoptosis; arugula; cell cycle; cell movement; cell viability; chemoprevention; glucosinolates; humans; hydrogen sulfide; hydrolysis; isothiocyanates; mutation; neoplasm cells; pancreatic neoplasms; phosphorylation; thioglucosidase
Abstract:
... Plants of the Brassicaceae family are well‐known for containing the glucosinolate myrosinase system, which is able to release isothiocyanates after plant biotic and abiotic lesions. Erucin (ERU; 1‐isothiocyanato‐4‐(methylthio)‐butane), an isothiocyanate particularly abundant in arugula (Eruca sativa Mill., Eruca vesicaria L., etc.), derives from the hydrolysis of the glucosinolate glucoerucin by t ...
DOI:
10.1002/ptr.6278

13. Antioxidant, cytotoxicity and anti-tumor activity of Cordia dichotoma fruits accompanied with its volatile and sugar composition

Author:
Abeer Y. Ibrahim; Samah A. El-Newary; Gamil E. Ibrahim
Source:
Annals of agricultural science 2019 v.64 no.1 pp. 29-37
ISSN:
0570-1783
Subject:
Cordia dichotoma; alkaloids; alpha-phellandrene; alpha-terpineol; antineoplastic activity; antineoplastic agents; antioxidant activity; ascites; body weight; bornyl acetate; butyrates; carcinoma; catechin; chemical composition; cytotoxicity; dose response; fructose; fruit pulp; fruits; gallic acid; gas chromatography-mass spectrometry; glucose; hematologic tests; high performance liquid chromatography; ions; lethal dose 50; longevity; metals; mice; phenols; quercetin; sucrose; superoxide anion; tannins; volatile compounds
Abstract:
... The aim of the present research was to investigate the chemical composition, antioxidant and anti-tumor effects of Cordia dichotoma fruit pulp extract “CDFP-extract”. Day after intraperitoneal inoculation of Ehrlich ascites carcinoma (EAC) cells in mice, CDFP-extract was administered orally at 500 mg/kg body weight (equal to 0.10 of determined LD50) for ten consecutive days. CDFP-extract contains ...
DOI:
10.1016/j.aoas.2019.05.008

14. Antiproliferative steroidal glycosides from rhizomes of Polygonatum sibiricum

Author:
Di Zhou; Xuezheng Li; Wenhui Chang; Yueqing Han; Bo Liu; Gang Chen; Ning Li
Source:
Phytochemistry 2019 v.164 pp. 172-183
ISSN:
0031-9422
Subject:
Polygonatum sibiricum; Western blotting; antineoplastic activity; antineoplastic agents; computer simulation; cytotoxicity; glycosides; human cell lines; hydrogen bonding; inhibitory concentration 50; mass spectrometry; neoplasm cells; nuclear magnetic resonance spectroscopy; rhizomes; screening; spectral analysis
Abstract:
... Screening assays showed that total glycoside-rich fraction (TG) of rhizomes of Polygonatum sibiricum unveiled remarkable anti-proliferative activities against three cancer cell lines (A549, HepG2, and Caco2). Activity-guided isolation of TG afforded seven undescribed steroidal glycosides (polygonosides 1–7), along with 24 known glycosides. Their structures were established by 1D and 2D NMR spectro ...
DOI:
10.1016/j.phytochem.2019.05.013

15. Antitumor Effect of Lonidamine-Polypeptide-Peptide Nanoparticles in Breast Cancer Models

Author:
Ifat Cohen-Erez; Carol Issacson; Yael Lavi; Ruthy Shaco-Levy; Jammi Milam; Brenda Laster; Levi A. Gheber; Hanna Rapaport
Source:
ACS applied materials & interfaces 2019 v.11 no.36 pp. 32670-32678
ISSN:
1944-8252
Subject:
adverse effects; animal models; antineoplastic activity; antineoplastic agents; biocompatible materials; breast neoplasms; cancer therapy; cell culture; clinical trials; cytotoxicity; drug delivery systems; freeze drying; glutamic acid; glycolysis; hepatotoxicity; intravenous injection; mitochondria; nanoparticles; neoplasm cells; pharmacokinetics; polyglutamic acid; polypeptides; solubility
Abstract:
... Biomaterials folded into nanoparticles (NPs) can be utilized as targeted drug delivery systems for cancer therapy. NPs may provide a vehicle for the anticancer drug lonidamine (LND), which inhibits glycolysis but was suspended from use at the clinical trial stage because of its hepatotoxicity due to poor solubility and pharmacokinetic properties. The NPs prepared by coassembly of the anionic polyp ...
DOI:
10.1021/acsami.9b09886

16. Antitumor Potential of Marine and Freshwater Lectins

Author:
Elena Catanzaro; Cinzia Calcabrini; Anupam Bishayee; Carmela Fimognari
Source:
Marine drugs 2019 v.18 no.1 pp. -
ISSN:
1660-3397
Subject:
algae; antineoplastic activity; antineoplastic agents; biodiversity; cell death; cell proliferation; clinical trials; freshwater; glycoproteins; lectins; marine environment; neoplasm cells; neoplasms; sugars; toxicity; toxicology; vertebrates
Abstract:
... Often, even the most effective antineoplastic drugs currently used in clinic do not efficiently allow complete healing due to the related toxicity. The reason for the toxicity lies in the lack of selectivity for cancer cells of the vast majority of anticancer agents. Thus, the need for new potent anticancer compounds characterized by a better toxicological profile is compelling. Lectins belong to ...
DOI:
10.3390/md18010011

17. Antrodia salmonea suppresses invasion and metastasis in triple-negative breast cancer cells by reversing EMT through the NF-κB and Wnt/β-catenin signaling pathway

Author:
You-Cheng Hseu; Yi-Chun Lin; Peramaiyan Rajendran; Varadharajan Thigarajan; Dony Chacko Mathew; Kai-Yuan Lin; Tzong-Der Way; Jiunn-Wang Liao; Hsin-Ling Yang
Source:
Food and chemical toxicology 2019 v.124 pp. 219-230
ISSN:
0278-6915
Subject:
Antrodia; Western blotting; antineoplastic activity; antineoplastic agents; beta catenin; bioluminescence; breast neoplasms; cadherins; enzyme activity; fluorescent antibody technique; fungi; image analysis; immunohistochemistry; luciferase; lungs; metastasis; mice; neoplasm cells; reverse transcriptase polymerase chain reaction; signal transduction; staining; tau-protein kinase; toxicology; transcription factor NF-kappa B; vascular endothelial growth factors; vimentin; Taiwan
Abstract:
... Antrodia salonea (AS), a fungus that is indigenous to Taiwan has been well known for its anti-cancer properties. We investigated the anti-metastatic and anti-epithelial-mesenchymal transition (EMT) properties of AS in TNBC cells. To determine their EMT and metastasis levels, in vitro wound healing, wound invasion, Western blotting, RT-PCR, luciferase activity and immunofluorescence assays were per ...
DOI:
10.1016/j.fct.2018.12.009

18. Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells

Author:
José C. Quilles Junior; Fernanda dos Reis Rocho Carlos; A. Montanari; Andrei Leitão; Viviane W. Mignone; Maria Augusta Arruda; Lyudmila Turyanska; Tracey D. Bradshaw
Source:
RSC advances 2019 v.9 no.63 pp. 36699-36706
ISSN:
2046-2069
Subject:
antineoplastic activity; antineoplastic agents; carcinogenesis; cathepsin L; cell cycle checkpoints; cysteine proteinase inhibitors; encapsulation; enzyme inhibition; ferritin; fibroblasts; humans; in vivo studies; neoplasm cells; neoplasms; protein degradation; transferrin receptors
Abstract:
... Cysteine proteases play a key role in tumorigenesis causing protein degradation and promoting invasive tumour growth. Cathepsin L is overexpressed in cancer cells and could provide a specific target for delivery of anticancer agents. We encapsulated novel dipeptidyl nitrile based cysteine protease inhibitors (Neq0551, Neq0554 and Neq0568) into biocompatible apoferritin (AFt) protein nanocages to a ...
DOI:
10.1039/c9ra07161j

19. Apoptosis and G2/M cell cycle arrest induced by a timosaponin A3 from Anemarrhena asphodeloides Bunge on AsPC-1 pancreatic cancer cells

Author:
Yumi Kim; Kang-Hoon Kim; In-Seung Lee; Ji Young Park; Yun-Cheol Na; Won-Seok Chung; Hyeung-Jin Jang
Source:
Phytomedicine 2019 v.56 pp. 48-56
ISSN:
0944-7113
Subject:
Anemarrhena asphodeloides; active ingredients; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cell growth; cell lines; cell proliferation; chemical constituents of plants; cyclins; cytotoxicity; drug therapy; ethyl acetate; genes; humans; immunoblotting; liquid chromatography; mass spectrometry; mechanism of action; metastasis; mitogen-activated protein kinase; neoplasm cells; pancreatic neoplasms; protein content; reverse transcription; saponins; solvents; viability
Abstract:
... Timosaponin A3 (TA3), one of the active components of spirostanol saponin isolated from A. asphodeloides, is widely used as an anticancer agent in a variety of cancer cell lines. However, the research on the anticancer efficacy is very limited in human pancreatic cancer models.In this study, we investigated the molecular targets in the active components of A. asphodeloides, which showed anti-cance ...
DOI:
10.1016/j.phymed.2018.08.006

20. Apoptosis effect of Aegiceras corniculatum on human colorectal cancer via activation of FoxO signaling pathway

Author:
Hua Luo; Erwei Hao; Dechao Tan; Wei Wei; Jinling Xie; Xiaohui Feng; Zhengcai Du; Chunying Huang; Gang Bai; Yuanyuan Hou; Chuanjing Cheng; Xiangxi Yi; Yitao Wang; Xiaotao Hou; Jiagang Deng
Source:
Food and chemical toxicology 2019 pp. -
ISSN:
0278-6915
Subject:
Aegiceras corniculatum; Western blotting; antineoplastic activity; antineoplastic agents; apoptosis; butanol; cell cycle checkpoints; cell lines; cell proliferation; colorectal neoplasms; dose response; flow cytometry; human diseases; leaf extracts; leaves; mechanism of action; mice; mitochondria; neoplasm cells; patients; proteins; signal transduction; viability
Abstract:
... Aegiceras corniculatum (L.) Blanco is known to exhibit anticancer effects against different types of cancer; however, to the best of our knowledge, the anticancer activity and underlying mechanisms of action of A. corniculatum leaf extract on colorectal cancer have not been elucidated. In the present study, colony-forming assay, western blot analysis, flow cytometry, and a xenograft model were use ...
DOI:
10.1016/j.fct.2019.110861

21. Ascochlorin induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages

Author:
Junyoung Park; Hee-Do Kim; Sook-Hyun Lee; Choong-Hwan Kwak; Young-Chae Chang; Young-Choon Lee; Tae-Wook Chung; Junji Magae; Cheorl-Ho Kim
Source:
Journal of ethnopharmacology 2019 v.239 pp. 111898
ISSN:
0378-8741
Subject:
Ascochyta; Pisum sativum; antibiotics; antineoplastic activity; antineoplastic agents; apoptosis; blight; caspase-3; caspase-8; cell viability; colorectal neoplasms; enzyme inhibitors; flow cytometry; fungi; macrophages; necroptosis; neoplasm cells; peas; staining; traditional medicine; trypanosomiasis
Abstract:
... Plant-specific fungus of natural compound of Ascochyta viciae has traditionally been used in the treatment of sleeping sickness and tumors. The anti-tumor activities of the compounds obtained from Pisum sativum L were evaluated in this study.In this study, during the prolonged incubation, treatment of the LPS-stimulated tumor-like macrophage RAW 264.7 cells with ASC exhibited the shift of anti-inf ...
DOI:
10.1016/j.jep.2019.111898

22. Assessing Anticancer Potential of Blueberry Flavonoids, Quercetin, Kaempferol, and Gentisic Acid, Through Oxidative Stress and Apoptosis Parameters on HCT-116 Cells

Author:
Ebru Demirel Sezer; Latife Merve Oktay; Elif Karadadaş; Hikmet Memmedov; Nur Selvi Gunel; Eser Sözmen
Source:
Journal of medicinal food 2019 v.22 no.11 pp. 1118-1126
ISSN:
1557-7600
Subject:
2,5-dihydroxybenzoic acid; Vaccinium myrtillus; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; blueberries; cytotoxicity; diet; flow cytometry; fruit extracts; kaempferol; liquid chromatography; neoplasms; oxidants; oxidative stress; polyphenols; protein composition; protein microarrays; proteins; quercetin; tandem mass spectrometry; therapeutics
Abstract:
... In recent years, natural products gained popularity with their anti-inflammatory and antioxidant effects mediated by chemical compounds within their composition. Study results offering them as palliative therapy options in cancer or as anticancer agents with high levels of cytotoxicity brought a new approach to combine cancer treatment protocols with these products. From a different perspective, e ...
DOI:
10.1089/jmf.2019.0098

23. Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential

Author:
Anna Hordyjewska; Aleksandra Ostapiuk; Anna Horecka; Jacek Kurzepa
Source:
Phytochemistry reviews 2019 v.18 no.3 pp. 929-951
ISSN:
1568-7767
Subject:
Betula; antineoplastic activity; antineoplastic agents; apoptosis; bark; betulin; betulinic acid; mechanism of action; metabolites; neoplasm cells; neoplasms; oxidation; therapeutics
Abstract:
... Betulin, a pentacyclic triterpene and a plant pentacyclic triterpene metabolite, can be found in large quantities in the outer bark of the birches (Betula, Betulaceae). Betulinic acid, obtained by betulin oxidation, is also abundantly present in nature. Both compounds show a wide spectrum of biological and pharmacological properties, such as anti-HIV, anti-inflammatory, and, considered the most im ...
DOI:
10.1007/s11101-019-09623-1

24. C-prenylated flavonoids with potential cytotoxic activity against solid tumor cell lines

Author:
Lenka Molčanová; Dominika Janošíková; Stefano Dall´Acqua; Karel Šmejkal
Source:
Phytochemistry reviews 2019 v.18 no.4 pp. 1051-1100
ISSN:
1568-7767
Subject:
antineoplastic activity; antineoplastic agents; bioassays; cell culture; cell lines; chemoprevention; cytotoxicity; drug therapy; flavanones; flavonols; in vitro studies; isoflavonoids; neoplasm cells; neoplasms; oxygen; secondary metabolites
Abstract:
... Natural products of plant origin or their semisynthetic derivatives acting as chemopreventive or chemotherapeutic agents for various types of cancer are under study as potential new anticancer drugs. Within the huge class of plant phenolic secondary metabolites, the subclass of prenylated flavonoids is quite rich in structural variety and pharmacological activity. One of their most prominent chara ...
DOI:
10.1007/s11101-019-09641-z

25. C30 and C31 Triterpenoids and Triterpene Sugar Esters with Cytotoxic Activities from Edible Mushroom Fomitopsis pinicola (Sw. Ex Fr.) Krast

Author:
Xing-Rong Peng; Hai-Guo Su; Jun-Hong Liu; Yan-Jie Huang; Xin-Zhi Yang; Zhong-Rong Li; Lin Zhou; Ming-Hua Qiu
Source:
Journal of agricultural and food chemistry 2019 v.67 no.37 pp. 10330-10341
ISSN:
1520-5118
Subject:
Fomitopsis pinicola; antineoplastic activity; antineoplastic agents; apoptosis; chemical composition; cytotoxicity; esters; flow cytometry; glycosides; health foods; human cell lines; humans; inhibitory concentration 50; methanol; mushrooms; neoplasm cells; nuclear magnetic resonance spectroscopy; structure-activity relationships; sugars; triterpenoids
Abstract:
... Fomitopsis pinicola (Sw. Ex Fr.) Krast has been commonly used as a health food source and antitumor agent. To uncover bioactive key composition of F. pinicola, in our study, we investigated the chemical constituents of a methanol extract of F. pinicola and thirty-five lanostane-type tritetpenoids; 13 new compounds (1–13) and twenty-two known analogues (14–35) were isolated. Among them, compounds 1 ...
DOI:
10.1021/acs.jafc.9b04530

26. CD44 targeted redox-triggered self-assembly with magnetic enhanced EPR effects for effective amplification of gambogic acid to treat triple-negative breast cancer

Author:
Mangmang Sang; Lingfei Han; Renjie Luo; Wei Qu; Feng Zheng; Kaigang Zhang; Fulei Liu; Jingwei Xue; Wenyuan Liu; Feng Feng
Source:
Biomaterials science 2019 v.8 no.1 pp. 212-223
ISSN:
2047-4849
Subject:
antineoplastic activity; antineoplastic agents; bioavailability; biocompatibility; breast neoplasms; chitosan; cytotoxicity; disulfides; drug therapy; hyaluronic acid; iron oxides; magnetism; nanoparticles; neoplasm cells; oligosaccharides; pharmacokinetics; polyethylene glycol; solubility
Abstract:
... Gambogic acid (GA) is a natural anti-tumor drug whose application is restricted by its poor aqueous solubility and inefficient bioavailability. Developing nanomaterials with excellent biocompatibility can amplify the therapeutic effects of GA. In this study, a tumor-targeted redox controllable self-assembled nano-system with magnetic enhanced EPR effects (mPEG-HA/CSO-SS-Hex/SPION/GA) was developed ...
DOI:
10.1039/c9bm01171d

27. Candelariella vitellina extract triggers in vitro and in vivo cell death through induction of apoptosis: A novel anticancer agent

Author:
Islam M. El-Garawani; Waill A. Elkhateeb; Gihan M. Zaghlol; Rafa S. Almeer; Eman F. Ahmed; Mostafa E. Rateb; Ahmed E. Abdel Moneim
Source:
Food and chemical toxicology 2019 v.127 pp. 110-119
ISSN:
0278-6915
Subject:
Candelariella vitellina; antineoplastic activity; antineoplastic agents; apoptosis; cytotoxicity; electrospray ionization mass spectrometry; forests; gene expression; gene expression regulation; high performance liquid chromatography; human cell lines; humans; inhibitory concentration 50; lichens; lymphocytes; mechanism of action; messenger RNA; mitochondria; neoplasm cells; polyketides; rocks; terpenoids; wood
Abstract:
... Candelariella vitellina is common green-yellow lichen found on barks, wood, and rocks in Japanese forests. To investigate the mechanism of its anticancer potential, C. vitellina (80% MeOH/H2O) extract was prepared. High-performance liquid chromatography–high-resolution electrospray ionization mass spectrometry analysis revealed seven new compounds and 11 natural compounds of terpenes and polyketid ...
DOI:
10.1016/j.fct.2019.03.003

28. Carbon monoxide (CO)-Strengthened cooperative bioreductive anti-tumor therapy via mitochondrial exhaustion and hypoxia induction

Author:
Yongjuan Li; Juanjuan Dang; Qiujun Liang; Lichen Yin
Source:
Biomaterials 2019 v.209 pp. 138-151
ISSN:
0142-9612
Subject:
anaerobic conditions; antineoplastic activity; antineoplastic agents; apoptosis; blood circulation; carbon monoxide; drug therapy; hypoxia; iron; irradiation; mitochondria; nanoparticles; neoplasm cells; neoplasms; oxygen consumption; porous media
Abstract:
... Bioreductive chemodrugs require hypoxic conditions to activate their anti-cancer efficacy. The insufficient and heterogeneous hypoxic condition in tumor tissues hurdles the therapeutic potency of bioreductive chemodrugs. We herein report a NIR light-triggered CO release system based on mesoporous Prussian blue nanoparticles (PB NPs) to enable cancer-selective hypoxia aggravation and hypoxia-respon ...
DOI:
10.1016/j.biomaterials.2019.04.004

29. Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF‐1α Axis of Breast Cancer Cells

Author:
Xin‐Xin Chai; Yi‐Fei Le; Jun‐Cheng Wang; Chen‐Xuan Mei; Jia‐Fan Feng; Hong Zhao; Cui Wang; De‐Zhao Lu
Source:
Journal of food science 2019 v.84 no.12 pp. 3825-3832
ISSN:
0022-1147
Subject:
Carpesium abrotanoides; antineoplastic activity; antineoplastic agents; breast neoplasms; functional foods; genes; glucose; glucose transporters; hexokinase; hypoxia-inducible factor 1; lactate dehydrogenase; mass spectrometry; medicinal plants; metabolism; neoplasm cells; pyruvate kinase; root extracts; roots; Asia
Abstract:
... Carpesium abrotanoides L. (CA) is widely used as a medicinal plant in Asia. The biological activities of the extract from the roots of Carpesium abrotanoides L. (PCA) and its major components were analyzed in this study. PCA was separated and identified with mass spectrometry. Furthermore, we sought to elucidate the anticancer activity of PCA and its mechanisms. PCA exerted its anti–breast cancer ...
DOI:
10.1111/1750-3841.14953

30. Carrier-Free Supramolecular Hydrogel Composed of Dual Drugs for Conquering Drug Resistance

Author:
Chunhua Ren; Yang Gao; Yong Guan; Zhongyan Wang; Lijun Yang; Jie Gao; Huirong Fan; Jianfeng Liu
Source:
ACS applied materials & interfaces 2019 v.11 no.37 pp. 33706-33715
ISSN:
1944-8252
Subject:
P-glycoproteins; antineoplastic activity; antineoplastic agents; biocompatibility; cancer therapy; caudal vein; drug delivery systems; drug resistance; drug therapy; histone deacetylase; hydrogels; hydrophilicity; hydrophobicity; nanofibers; neoplasm cells; neoplasms; paclitaxel
Abstract:
... The resistance of tumor cells to anticancer drugs has become one of the principal causes of the failure in clinical chemotherapy. To overcome this issue, developing feasible drug delivery systems for effective cancer therapy is urgently needed. In this work, we construct an amphiphilic drug self-delivery system consisting of Taxol and tyroservatide (YSV) to overcome drug resistance. The carrier-fr ...
DOI:
10.1021/acsami.9b12530

31. Changes Over the Fermentation Period in Phenolic Compounds and Antioxidant and Anticancer Activities of Blueberries Fermented by Lactobacillus plantarum

Author:
Ji‐Yeon Ryu; Hye Rim Kang; Somi Kim Cho
Source:
Journal of food science 2019 v.84 no.8 pp. 2347-2356
ISSN:
0022-1147
Subject:
2,2-diphenyl-1-picrylhydrazyl; Lactobacillus plantarum; additives; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; blueberries; catechol; chlorogenic acid; epigallocatechin; ethanol; fermentation; free radicals; gallic acid; high performance liquid chromatography; human cell lines; lactic acid bacteria; malvidin; metabolites; phenol; polyphenols; protocatechuic acid; syringic acid; uterine cervical neoplasms
Abstract:
... This study determined the effects of blueberry fermentation by Lactobacillus plantarum on antioxidant and anticancer activities. The fermented blueberries extracted with 80% ethanol (FBE) showed increased superoxide dismutase‐like activity, increased scavenging of DPPH and alkyl radicals, and increased antiproliferative activity against human cervical carcinoma HeLa cells by inducing apoptosis. Se ...
DOI:
10.1111/1750-3841.14731

32. Characterization of exopolysaccharides produced by microalgae with antitumor activity on human colon cancer cells

Author:
Jianzhi Zhang; Lu Liu; Yuanyuan Ren; Feng Chen
Source:
International journal of biological macromolecules 2019 v.128 pp. 761-767
ISSN:
0141-8130
Subject:
2,2-diphenyl-1-picrylhydrazyl; Chlorella pyrenoidosa; Chlorococcum; Scenedesmus; antineoplastic activity; antineoplastic agents; cell viability; colorectal neoplasms; exopolysaccharides; human cell lines; humans; hydroxyl radicals; microalgae; molecular weight; neoplasm cells; sugars
Abstract:
... The physicochemical characteristics, antioxidant and antitumor activities of partial purified exopolysaccharides from microalgae Chlorella pyrenoidosa FACHB-9, Scenedesmus sp. and Chlorococcum sp. were investigated. The molecular weights were 1.94 × 10⁵, 7.39 × 10³ and 3.24 × 10⁴ g/mol, respectively. Monosaccharide analysis indicating that these exopolysaccharides consisted of ten different kinds ...
DOI:
10.1016/j.ijbiomac.2019.02.009

33. Combination of 3-methyladenine therapy and Asn-Gly-Arg (NGR)-modified mesoporous silica nanoparticles loaded with temozolomide for glioma therapy in vitro

Author:
Peng Zhang; Menghuan Tang; Qin Huang; Guanjian Zhao; Ning Huang; Xiang Zhang; Ying Tan; Yuan Cheng
Source:
Biochemical and biophysical research communications 2019 v.509 no.2 pp. 549-556
ISSN:
0006-291X
Subject:
antineoplastic activity; antineoplastic agents; autophagy; glioma; nanoparticles; neoplasm cells; porous media; silica; therapeutics
Abstract:
... Mesoporous silica nanoparticles (MSNPs) of a small diameter were loaded with the anticancer drug temozolomide (TMZ), coated with polydopamine (PDA), and conjugated with Asn-Gly-Arg (NGR) for use in the treatment of glioma. The accumulation of NGR-MSNPs in C6 cells was shown to be higher than that of unmodified MSNPs. Anticancer drugs can cause autophagy in tumor cells, whereas autophagy inhibitors ...
DOI:
10.1016/j.bbrc.2018.12.158

34. Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents

Author:
Haosha Tang; Yunyan Kuang; Julan Zeng; Xiaofang Li; Wei Zhou; Yuan Lu
Source:
RSC advances 2019 v.9 no.54 pp. 31474-31482
ISSN:
2046-2069
Subject:
alkynes; ambient temperature; antineoplastic activity; antineoplastic agents; dimethyl sulfoxide; neoplasm cells
Abstract:
... Combinatorial synthesis of (E)-β-trifluoromethyl vinylsulfones is accomplished through a reaction of alkynes, Togni reagent, and sodium benzenesulfinates in DMSO under metal-free conditions at room temperature. These compounds are evaluated in several assays against different tumor cells. Some hits are identified against ES-2, HO-8910, and K562. ...
DOI:
10.1039/c9ra06368d

35. Combretastatin A4-camptothecin micelles as combination therapy for effective anticancer activity

Author:
Mohyeddin Assali; Naim Kittana; Sahar Alhaj Qasem; Raghad Adas; Doaa Saleh; Asala Arar; Osayd Zohud
Source:
RSC advances 2019 v.9 no.2 pp. 1055-1061
ISSN:
2046-2069
Subject:
antineoplastic activity; antineoplastic agents; atomic force microscopy; cytotoxicity; drug therapy; drug toxicity; esterases; fibroblasts; human cell lines; hydrolysis; hydrophilicity; image analysis; light scattering; micelles; neoplasm cells; neoplasms; pH; synergism; water solubility
Abstract:
... Cancer is a major worldwide health problem, for which chemotherapy is a common treatment option. However drug toxicity and the development of resistance to chemotherapy are two main challenges associated with the traditional anticancer drugs. Combined pharmacological therapy based on different mechanisms might be an effective strategy in cancer treatment, and could exhibit a synergistic therapeuti ...
DOI:
10.1039/c8ra08794f

36. Comparative study of antidiabetic, bactericidal, and antitumor activities of MEL@AgNPs, MEL@ZnONPs, and Ag–ZnO/MEL/GA nanocomposites prepared by using MEL and gum arabic

Author:
Abdelmoneim Bakur; Tarig Elshaarani; Yongwu Niu; Qihe Chen
Source:
RSC advances 2019 v.9 no.17 pp. 9745-9754
ISSN:
2046-2069
Subject:
Fourier transform infrared spectroscopy; X-ray diffraction; alpha-amylase; alpha-glucosidase; antibacterial properties; antibiotics; antineoplastic activity; antineoplastic agents; glycemic effect; gum arabic; human cell lines; inhibitory concentration 50; nanocomposites; physicochemical properties; scanning electron microscopy; transmission electron microscopy
Abstract:
... In this study, a variety of nanocomposites, namely, MEL@AgNPs, MEL@ZnONPs, and Ag–ZnO/MEL/GA were biosynthesized using MEL and gum arabic to serve in biomedical applications. The synthesized nanocomposites were examined using X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and FTIR spectroscopy. The physicochemical properties and biomedical acti ...
DOI:
10.1039/c9ra00344d

37. Complete genome sequence of Streptomyces spongiicola HNM0071T, a marine sponge-associated actinomycete producing staurosporine and echinomycin

Author:
Shuangqing Zhou; Ke Xiao; Dongyi Huang; Wenqiang Wu; Yun Xu; Wei Xia; Xiaolong Huang
Source:
Marine genomics 2019 v.43 pp. 61-64
ISSN:
1874-7787
Subject:
Streptomyces; antibiotics; antineoplastic activity; antineoplastic agents; biosynthesis; chromosomes; multigene family; nucleotide sequences; ribosomal RNA; secondary metabolites; staurosporine; transfer RNA
Abstract:
... Streptomyes spongiicola HNM0071T is a novel marine sponge-associated actinomycete with potential to produce antitumor agents including staurosporine and echinomycin. Here, we present the complete genome sequence of S. spongiicola HNM0071, which consists of a linear chromosome of 7,180,417 bp, 5669 protein coding genes, 18 rRNA genes, and 66 tRNA genes. Twenty-seven putative secondary metabolite bi ...
DOI:
10.1016/j.margen.2018.08.002

38. Conjugated Linolenic Acids: Implication in Cancer

Author:
Kaushik K. Dhar Dubey; Girish Sharma; Aruna Kumar
Source:
Journal of agricultural and food chemistry 2019 v.67 no.22 pp. 6091-6101
ISSN:
1520-5118
Subject:
anticarcinogenic activity; antineoplastic activity; antineoplastic agents; antioxidants; chemoprevention; clinical trials; conjugated linoleic acid; conjugated linolenic acid; health promotion; in vivo studies; neoplasms; seeds
Abstract:
... Conjugated fatty acids (CFAs) including both conjugated linoleic acids (CLAs) and conjugated linolenic acids (CLNAs) have various health promoting effects. These beneficial effects are comprised by their antioxidant, antiatherogenecity, anticarcinogenic activities, etc. Several reports indicate that CLNAs such as eleostearic acid, punicic acid, jacaric acid, and calendic acid possess anticancer pr ...
DOI:
10.1021/acs.jafc.9b01379

39. Correction to: Identification of N-arylsulfonylpyrimidones as anticancer agents

Author:
Santhosh Subramanian; Pulla Reddy Boggu; Jieun Yun; Sang-Hun Jung
Source:
Archives of pharmacal research 2019 v.42 no.4 pp. 371
ISSN:
0253-6269
Subject:
antineoplastic activity; antineoplastic agents; human cell lines; neoplasm cells
Abstract:
... The author would like to include conflict of interest statement of the online published article. The correct conflict of interest statement should read as: The authors declare no conflict of interest. ...
DOI:
10.1007/s12272-019-01121-4

40. Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells and modulate Wnt/β-catenin signaling and apoptotic pathways in A375 cells

Author:
Nishtha S Srivastava; Rai Ajit K Srivastava
Source:
Phytomedicine 2019 v.52 pp. 117-128
ISSN:
0944-7113
Subject:
anti-inflammatory activity; antineoplastic activity; antineoplastic agents; apoptosis; berberine; beta catenin; caspases; cell lines; cell proliferation; curcumin; cyclins; epigallocatechin; inhibitory concentration 50; mechanism of action; melanoma; mitogen-activated protein kinase; neoplasm cells; phosphatidylinositol 3-kinase; quercetin; signal transduction; synergism; therapeutics; transcription factor NF-kappa B
Abstract:
... Traditional therapy using natural products, especially flavonoids and alkaloids have been in practice for a long time. Among flavonoids, curcumin, quercetin, berberine, and epigallocatechin have been studied in greater detail in terms of their anticancer and anti-inflammatory activities. Although many studies focused on the PI3K, MAP kinase and NF-κB pathways, a thorough investigation of modulatio ...
DOI:
10.1016/j.phymed.2018.09.224

41. Cyanidin inhibits EMT induced by oxaliplatin via targeting the PDK1–PI3K/Akt signaling pathway

Author:
Xiang Li; Ze-sheng Zhang; Xiao-han Zhang; Sheng-nan Yang; Dong Liu; Cui-ru Diao; Hao Wang; Fu-ping Zheng
Source:
Food & function 2019 v.10 no.2 pp. 592-601
ISSN:
2042-650X
Subject:
Crataegus; anthocyanins; antineoplastic activity; antineoplastic agents; biomarkers; black beans; black rice; cyanidin; drug resistance; foods; metastasis; neoplasms; patients; protein kinases; relapse; signal transduction
Abstract:
... Anthocyanins have been shown to exhibit antitumor activity in several cancers in vitro and in vivo. Oxaliplatin is widely used as an anti-cancer drug. However, a large proportion of patients receiving platinum-based anti-cancer drug treatments will relapse because of metastasis and drug resistance. The aim of this study is to discover an effective anthocyanin that possesses the combinational anti- ...
DOI:
10.1039/c8fo01611a

42. Cytotoxic, genotoxic, and oxidative stress-inducing effect of an l-amino acid oxidase isolated from Bothrops jararacussu venom in a co-culture model of HepG2 and HUVEC cells

Author:
A.R.T. Machado; A.F. Aissa; D.L. Ribeiro; T.R. Costa; R.S. Ferreira Jr.; S.V. Sampaio; L.M.G. Antunes
Source:
International journal of biological macromolecules 2019 v.127 pp. 425-432
ISSN:
0141-8130
Subject:
Bothrops; DNA; DNA damage; L-amino-acid oxidase; antineoplastic activity; antineoplastic agents; cell death; coculture; comet assay; cytotoxicity; drug therapy; fluorescence; genotoxicity; hepatoma; human cell lines; human umbilical vein endothelial cells; humans; micronucleus tests; models; mutagens; neoplasm cells; oxidative stress; snake venoms
Abstract:
... Hepatocellular carcinoma incidence rates have increased worldwide, which encouraged the development of new chemotherapeutic drugs. l-Amino acid oxidases from snake venoms are cytotoxic towards human tumor cells in in vitro monoculture systems, which do not simulate the tumor microenvironment. We examined the antitumor potential of BjussuLAAO-II, an l-amino acid oxidase from Bothrops jararacussu ve ...
DOI:
10.1016/j.ijbiomac.2019.01.059

43. DT-13 inhibited the proliferation of colorectal cancer via glycolytic metabolism and AMPK/mTOR signaling pathway

Author:
Xiaohui Wei; Tingting Mao; Sijing Li; Jinyong He; Xiaoying Hou; Hongyang Li; Meixiao Zhan; Xiangyu Yang; Ruiming Li; Jing Xiao; Shengtao Yuan; Li Sun
Source:
Phytomedicine 2019 v.54 pp. 120-131
ISSN:
0944-7113
Subject:
Western blotting; adenosine triphosphate; animal models; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cell proliferation; chemoprevention; colorectal neoplasms; dose response; enzymes; glucose; glycolysis; humans; immunohistochemistry; intestines; lactic acid; messenger RNA; neoplasm cells; protein content; quantitative polymerase chain reaction; signal transduction; staining; steroid saponins; toxicity; tubers
Abstract:
... Emerging hallmark of cancer is reprogrammed cellular metabolism, increased glycolytic metabolism is physiological characteristic of human malignant neoplasms. Saponin monomer 13 of the dwarf lilyturf tuber (DT-13) is the main steroidal saponin from Liriopes Radix, which has been reported to exert anti-inflammation and anti-tumor activities but low toxicity to normal tissue. However, the effect of ...
DOI:
10.1016/j.phymed.2018.09.003

44. Development of curcumin-loaded gemini surfactant nanoparticles: Synthesis, characterization and evaluation of anticancer activity against human breast cancer cell lines

Author:
Mina Karimpour; Mohammad Ali Hosseinpour Feizi; Majid Mahdavi; Barbara Krammer; Thomas Verwanger; Farhood Najafi; Esmaeil Babaei
Source:
Phytomedicine 2019 v.57 pp. 183-190
ISSN:
0944-7113
Subject:
X-ray diffraction; antineoplastic activity; antineoplastic agents; apoptosis; bioavailability; breast neoplasms; cell proliferation; curcumin; cytotoxicity; genes; high performance liquid chromatography; human cell lines; humans; light scattering; micelles; nanocarriers; nanoparticles; neoplasm cells; particle size; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; surfactants; turmeric; viability; zeta potential
Abstract:
... Curcumin, the polyphenolic constituent of turmeric, has been recognized as an effective anticancer agent in the treatment of breast cancer. However, the poor bioavailability of curcumin triggers finding of new approaches for elevating its therapeutic efficiency.We aimed to use gemini surfactant nanocarriers for curcumin in order to overcome its limitations.We investigated the in vitro characteriza ...
DOI:
10.1016/j.phymed.2018.11.017

45. Devil’s Club Falcarinol-Type Polyacetylenes Inhibit Pancreatic Cancer Cell Proliferation

Author:
Susan S. C. Cheung; David Hasman; Djamel Khelifi; Joseph Tai; Richard W. Smith; Garth L. Warnock
Source:
Nutrition and cancer 2019 v.71 no.2 pp. 301-311
ISSN:
1532-7914
Subject:
Oplopanax horridus; antibodies; antineoplastic activity; antineoplastic agents; apoptosis; bark; cell cycle; cell proliferation; chemical bonding; death domain receptors; ethanol; genes; human cell lines; inhibitory concentration 50; labor; liquid chromatography; mass spectrometry; mechanism of action; microscopy; neoplasm cells; pancreatic neoplasms; polyacetylenes; synthesis
Abstract:
... Natural falcarinol-type (FC-type) polyacetylenes are known to show anticancer activities. We studied the bioactivity of synthetic FC, 1,2-dihydrofalcarinol (FCH) and 3-acetoxyfalcarinol (FCA) and compared them with the natural bioactive polyacetylene [9,17-octadecadiene-12,14-diyne-1,11,16-triol,1-acetate] (DCA) isolated from Devil’s club (DC) Oplopanax horridus. Antiproliferation activity of thes ...
DOI:
10.1080/01635581.2018.1559931

46. Diosgenyl Saponin Inducing Endoplasmic Reticulum Stress and Mitochondria-Mediated Apoptotic Pathways in Liver Cancer Cells

Author:
Xin Meng; Honghong Dong; Yiwu Pan; Long Ma; Changxiao Liu; Shuli Man; Wenyuan Gao
Source:
Journal of agricultural and food chemistry 2019 v.67 no.41 pp. 11428-11435
ISSN:
1520-5118
Subject:
NAD ADP-ribosyltransferase; antineoplastic activity; antineoplastic agents; apoptosis; autophagy; bioactive compounds; caspase-8; chloroquine; diosgenin; endoplasmic reticulum; endoplasmic reticulum stress; fenugreek; glucosamine; liver neoplasms; lysosomes; mitochondria; neoplasm cells; plasma membrane; polypeptides; roots; seeds; transmission electron microscopy; yams
Abstract:
... Diosgenin and diosgenyl saponins as the major bioactive compounds isolated from dietary fenugreek seeds, yam roots, etc. possessed strong antitumor effects. To understand their detailed antitumor mechanisms, a fluorophore-appended derivative of diosgenin [Glc/CNHphth-diosgenin (GND)] was synthesized, starting from diosgenin and glucosamine hydrochloride in overall yields of 7–12% over 7–10 steps. ...
DOI:
10.1021/acs.jafc.9b05131

47. Diselenium-containing ultrathin polymer nanocapsules for highly efficient targeted drug delivery and combined anticancer effect

Author:
Shuang Fu; Fei Li; Mingsong Zang; Zherui Zhang; Yuancheng Ji; Xiaoxuan Yu; Quan Luo; Shuwen Guan; Jiayun Xu; Junqiu Liu
Source:
Journal of materials chemistry B 2019 v.7 no.32 pp. 4927-4932
ISSN:
2050-7518
Subject:
antineoplastic activity; antineoplastic agents; biocompatible materials; crosslinking; medicine; nanocapsules; nanocarriers; neoplasm progression; peptides; polymers; selenium
Abstract:
... The combination of selenium and pillararenes to prepare selenium-containing pillararene-based biomaterials is of great significance for the development of biomedicine. Herein, using a covalent self-assembly strategy, we successfully developed new diselenium-containing ultrathin polymer nanocapsules based on lateral cross-linked pillararenes. The new system exhibited a very potent anticancer effect ...
DOI:
10.1039/c9tb01200a

48. Drug-Initiated Synthesis of Heterotelechelic Polymer Prodrug Nanoparticles for in Vivo Imaging and Cancer Cell Targeting

Author:
Daniele Vinciguerra; Anna Degrassi; Laura Mancini; Simona Mura; Julie Mougin; Patrick Couvreur; Julien Nicolas
Source:
Biomacromolecules 2019 v.20 no.7 pp. 2464-2476
ISSN:
1526-4602
Subject:
antineoplastic activity; antineoplastic agents; biotin; body weight changes; cytotoxicity; dyes; humans; hydrophilicity; image analysis; liver; lung neoplasms; mice; nanoparticles; near-infrared spectroscopy; neoplasm cells; particle size distribution; polymers
Abstract:
... “Drug-initiated” nitroxide-mediated synthesis of two well-defined, heterotelechelic polymer prodrugs (Mₙ = 1960–5260 g·mol–¹, Đ = 1.31–1.37) was performed by using the newly developed nitroxide exchange reaction. These polymers comprised, at the chain end, gemcitabine (Gem) as anticancer drug and either cyanine 7.5 (Cy7.5) as a near-infrared (NIR) dye suitable for in vivo imaging or biotin (Biot) ...
DOI:
10.1021/acs.biomac.9b00148

49. Dual-Responsive Size-Shrinking Nanocluster with Hierarchical Disassembly Capability for Improved Tumor Penetration and Therapeutic Efficacy

Author:
Xiaoyan Sun; Jiulong Zhang; Chunrong Yang; Ziyuan Huang; Menghao Shi; Shuang Pan; Haiyang Hu; Mingxi Qiao; Dawei Chen; Xiuli Zhao
Source:
ACS applied materials & interfaces 2019 v.11 no.12 pp. 11865-11875
ISSN:
1944-8252
Subject:
animal models; antineoplastic activity; antineoplastic agents; cytotoxicity; extracellular matrix; gelatinase A; micelles; nanoparticles; neoplasms; paclitaxel; particle size; therapeutics
Abstract:
... It is generally known that, for nanoparticles in cancer therapy, sufficient tumor penetration needs a minor particle size, while long in vivo circulation time needs a larger particle size. It is hard to balance them because they are standing on either side of a seesaw. To address these two different requirements, a dual-responsive size-shrinking nanocluster can self-adaptively respond to a complic ...
DOI:
10.1021/acsami.8b21580

50. Dual-targeting nanotherapeutics antagonize hyperinsulinemia-promoted tumor growth via activating cell autophagy

Author:
Jiarun Huang; Yuedan Liu; Ting Liu; Yanzhou Chang; Tianfeng Chen; Xiaoling Li
Source:
Journal of materials chemistry B 2019 v.7 no.43 pp. 6751-6758
ISSN:
2050-7518
Subject:
antineoplastic activity; antineoplastic agents; apoptosis; autophagy; chitosan; drug therapy; hyperinsulinemia; insulin; mitochondria; nanomedicine; nanoparticles; neoplasm cells; neoplasms; noninsulin-dependent diabetes mellitus; peptides; selenium; synergism
Abstract:
... Hyperinsulinemia, a concomitant symptom in type 2 diabetes mellitus (T2DM) promotes the migration, invasion and proliferation of tumors by inhibiting autophagy. Therefore, it is necessary to search for antitumor drugs that can effectively antagonize hyperinsulinemia by promoting autophagy. In this study, dual-targeting modified selenium nanoparticles (u/A-SeNPs) were proposed as a biocompatible tu ...
DOI:
10.1039/c9tb01197h