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- Author:
- Yahya Asemani; Nasrindokht Zamani; Maryam Bayat; Zahra Amirghofran
- Source:
- Phytotherapy research 2019 v.33 no.12 pp. 3019-3039
- ISSN:
- 0951-418X
- Subject:
- Allium; adverse effects; ajoene; antineoplastic activity; antineoplastic agents; antioxidant activity; apoptosis; cell cycle; chives; garlic; health effects assessments; ingredients; leeks; medicinal plants; metastasis; neoplasm cells; neoplasms; quercetin; shallots; signal transduction; sulfur; therapeutics; traditional medicine
- Abstract:
- ... Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, onions, leeks, chives, and shallots. These plants have been exploited in folk medicine because of their beneficial health effects in improving numerou ...
- DOI:
- 10.1002/ptr.6490
- https://doi.org/10.1002/ptr.6490
- Author:
- Jessica CeramellaThese authors have contributed equally to the manuscript.; Monica Rosa Loizzo; Domenico Iacopetta; Marco Bonesi; Vincenzo Sicari; Teresa Maria Pellicanò; Carmela Saturnino; Aurélie Malzert-Fréon; Rosa TundisJoint senior authors.; Maria Stefania Sinicropi
- Source:
- Food & function 2019 v.10 no.7 pp. 4280-4290
- ISSN:
- 2042-650X
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Anchusa azurea; aerial parts; antineoplastic activity; antioxidant activity; beta-carotene; bleaching; caffeic acid; caspase-3; catechin; cell death; cell lines; chemical composition; chlorogenic acid; cytoskeleton; death; high performance liquid chromatography; inhibitory concentration 50; menadione; methanol; mice; neoplasm cells; neoplasms; oxidative stress; toxicity
- Abstract:
- ... The present study aimed to determine the chemical composition, antioxidant effects and antitumor properties of a methanol extract of Anchusa azurea Mill. (Boraginaceae) aerial parts against four tumour cell lines (MCF-7, MDA-MB-231, RKO, and R₂C). The antioxidant effects were assessed by using β-carotene bleaching, 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picryl ...
- DOI:
- 10.1039/c9fo00582j
- https://doi.org/10.1039/c9fo00582j
- Author:
- Luan He; Yong Zhang; Naixin Kang; Yaner Wang; Ziyu Zhang; Zhengxia Zha; Shilin Yang; Qiongming Xu; Yanli Liu
- Source:
- Phytomedicine 2019 v.56 pp. 136-146
- ISSN:
- 0944-7113
- Subject:
- Anemone chinensis; Western blotting; adverse effects; anti-inflammatory activity; antineoplastic activity; antioxidant activity; apoptosis; blood; body weight; catalase; cell viability; cisplatin; creatinine; drug therapy; flow cytometry; glutathione; histopathology; in vivo studies; kidneys; mice; models; neoplasms; nephrotoxicity; protective effect; reactive oxygen species; renal failure; saponins; superoxide dismutase; urea nitrogen
- Abstract:
- ... Cisplatin is a highly effective chemotherapeutic agent commonly used in the treatment of a wide variety of malignancies. However, its clinical usage is severely limited by its serious side effects, especially nephrotoxicity. Anemoside B4, is a major saponins, rich in root of Pulsatilla chinensis (Bunge), has anti-inflammation in vitro. However, the antioxidant or anti-inflammatory effects of anemo ...
- DOI:
- 10.1016/j.phymed.2018.10.035
- https://doi.org/10.1016/j.phymed.2018.10.035
- Author:
- Chao Ma; Kun Yang; Yifan Wang; Xianjun Dai
- Source:
- Marine drugs 2019 v.17 no.11 pp. -
- ISSN:
- 1660-3397
- Subject:
- Drosophila melanogaster; agar; anti-aging properties; antineoplastic activity; antioxidant activity; catalase; gene expression regulation; genes; immunity; immunomodulators; insect reproduction; intestinal microorganisms; intestines; longevity; male fertility; males; malondialdehyde; microbial communities; midgut; oligosaccharides; prebiotics; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; ribosomal DNA; sequence analysis; vigor
- Abstract:
- ... Agar oligosaccharide (AOS) is a marine prebiotic with apparent anti-inflammatory, antioxidant and anti-tumor effects. During this study, different doses of AOS are added to a basal diet to evaluate its effects on the lifespan, motor vigor and reproduction of male Drosophila melanogaster. Additionally, the activities of Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and catalase (CAT) and the malondialdehy ...
- DOI:
- 10.3390/md17110632
- PubMed:
- 31698828
- PubMed Central:
- PMC6891751
- https://doi.org/10.3390/md17110632
- Author:
- Ha Na Kim; Jueng Kyu Baek; Su Bin Park; Jeong Dong Kim; Ho-Jun Son; Gwang Hun Park; Hyun Ji Eo; Jae Ho Park; Hyuk-Sang Jung; Jin Boo Jeong
- Source:
- BMC complementary and alternative medicine 2019 v.19 no.1 pp. 291
- ISSN:
- 1472-6882
- Subject:
- Vaccinium; Western blotting; acetylcholinesterase; alpha-amylase; alternative medicine; anti-inflammatory activity; antineoplastic activity; antioxidant activity; cathepsin K; cell viability; chemoprevention; enzyme activity; enzyme-linked immunosorbent assay; genes; inducible nitric oxide synthase; interleukin-1beta; interleukin-6; messenger RNA; mitogen-activated protein kinase; nitric oxide; phosphorylation; prostaglandins; protein content; reverse transcriptase polymerase chain reaction; stem extracts; stems; toxicity testing; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... BACKGROUND: Vaccinium oldhamii (V. oldhamii) has been reported to exert a variety of the pharmacological properties such as anti-oxidant activity, anti-cancer activity, and inhibitory activity of α-amylase and acetylcholinesterase. However, the anti-inflammatory activity of V. oldhamii has not been studied. In this study, we aimed to investigate anti-inflammatory activity of the stem extracts from ...
- DOI:
- 10.1186/s12906-019-2720-4
- PubMed:
- 31684931
- PubMed Central:
- PMC6827179
- https://doi.org/10.1186/s12906-019-2720-4
- Author:
- Adriana Nowak; Anna Paliwoda; Janusz Błasiak
- Source:
- Critical reviews in food science and nutrition 2019 v.59 no.21 pp. 3456-3467
- ISSN:
- 1549-7852
- Subject:
- Bifidobacterium; Lactobacillus; antineoplastic activity; antioxidant activity; antioxidant enzymes; apoptosis; bacteria; carcinogens; cell cycle; cell proliferation; molecular weight; neoplasm cells; neoplasms; proteins; reactive oxygen species; therapeutics; transition elements
- Abstract:
- ... Lactobacillus and Bifidobacterium strains, their isolated constituents and substances that they secrete exert various anti-cancer actions, resulting from their anti-proliferative, pro-apoptotic and anti-oxidant properties. They can express and secrete anti-oxidant enzymes, bind reactive oxygen species, release small molecular weight anti-oxidants and chelate transition metals, preventing detriment ...
- DOI:
- 10.1080/10408398.2018.1494539
- https://doi.org/10.1080/10408398.2018.1494539
- Author:
- Muhammad Shahid Riaz Rajoka; Haobin Zhao; Hafiza Mahreen Mehwish; Na Li; Yao Lu; Ziyang Lian; Dongyan Shao; Mingliang Jin; Qi Li; Liqing Zhao; Junling Shi
- Source:
- Food research international 2019 v.123 pp. 286-297
- ISSN:
- 0963-9969
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Lactobacillus rhamnosus; Western blotting; antineoplastic activity; antioxidant activity; apoptosis; breast milk; cell free system; cytotoxicity; free radicals; gene expression regulation; genes; human cell lines; human health; hydroxyl radicals; immune system; liquids; neoplasm cells; nutrients; pathogens; probiotics; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; superoxide anion; uterine cervical neoplasms
- Abstract:
- ... Lactobacilli rhamnosus has been characterized as a probiotic and plays an important role in human health by stimulating the supplement of nutrients, preventing the colonization of pathogens, and influencing the immune system. This study investigated the anticancer activity of the three Lactobacillus rhamnosus strains SHA111, SHA112, and SHA113 isolated from human breast milk. The cell-free superna ...
- DOI:
- 10.1016/j.foodres.2019.05.002
- https://doi.org/10.1016/j.foodres.2019.05.002
- Author:
- Remya Vijayan; Siby Joseph; Beena Mathew
- Source:
- Bioprocess and biosystems engineering 2019 v.42 no.2 pp. 305-319
- ISSN:
- 1615-7591
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Bauhinia purpurea; Fourier transform infrared spectroscopy; X-ray diffraction; agar; antineoplastic activity; antioxidant activity; antioxidants; catalysts; catalytic activity; cell lines; dose response; dyes; energy-dispersive X-ray analysis; gold; inhibitory concentration 50; leaf extracts; lung neoplasms; medicinal plants; nanogold; nanoparticles; nanosilver; neoplasm cells; silver; stabilizers; surface plasmon resonance; transmission electron microscopy
- Abstract:
- ... The synthesis of metal nanoparticles by green methods attained enormous attention in recent years due to its easiness, non-toxicity, and eco-friendly nature. In the present study, noble metal nanoparticles such as silver and gold were prepared using an aqueous leaf extract of a medicinal plant, Bauhinia purpurea. The leaf extract performed as both reducing and stabilizing agents for the developmen ...
- DOI:
- 10.1007/s00449-018-2035-8
- https://doi.org/10.1007/s00449-018-2035-8
- Author:
- Marwa M. Mohammed; Gamal Ramadan; Mona K. Zoheiry; Nadia M. El‐Beih
- Source:
- Environmental toxicology 2019 v.34 no.9 pp. 1025-1033
- ISSN:
- 1520-4081
- Subject:
- DNA fragmentation; animal models; antineoplastic activity; antioxidant activity; apoptosis; blood serum; body weight; carcinoma; caspases; catalase; cattle; cytotoxicity; diethylnitrosamine; dose response; drug therapy; glutathione; glutathione peroxidase; hepatoma; histology; inflammation; lactoferrin; liver; males; mice; superoxide dismutase; whey protein concentrate
- Abstract:
- ... Hepatocellular carcinoma is considered one of the most prevalent and lethal malignancies worldwide. Chemotherapy with cytotoxic agents showed a low response rate with possible toxic effects. Recently, some emphases have been placed on the anticancer properties of bovine whey protein and its components, especially lactoferrin. The present study aimed to evaluate and compare the antihepatocarcinogen ...
- DOI:
- 10.1002/tox.22773
- https://doi.org/10.1002/tox.22773
- Author:
- Claudia Lizet Meneses-Gutiérrez; Jacqueline Hernández-Damián; José Pedraza-Chaverri; Isabel Guerrero-Legarreta; Dario Iker Téllez; María Eugenia Jaramillo-Flores
- Source:
- Antioxidants 2019 v.8 no.7 pp. -
- ISSN:
- 2076-3921
- Subject:
- antineoplastic activity; antioxidant activity; catechin; cisplatin; copper; cytotoxicity; epicatechin; human cell lines; humans; iron; metal ions; neoplasm cells; oxidation; peroxidase; polymerization; reactive oxygen species; resveratrol; therapeutics; urinary bladder neoplasms
- Abstract:
- ... In this work the polymerization of catechin, epicatechin, and resveratrol was carried out through a peroxidase oxidation process in order to improve the biological activity of these phenolic compounds. The antioxidant activity of the oligomers was evaluated by their ability to scavenge reactive oxygen species (ROS) and their capacity to chelate metal ions Fe2+ and Cu2+. The antitumor effect of the ...
- DOI:
- 10.3390/antiox8070214
- PubMed:
- 31295839
- PubMed Central:
- PMC6680426
- https://doi.org/10.3390/antiox8070214
- Author:
- Monira M. Rageh; Reem H. El-Gebaly
- Source:
- Molecular biology reports 2019 v.46 no.3 pp. 3141-3148
- ISSN:
- 0301-4851
- Subject:
- DNA damage; antineoplastic activity; antioxidant activity; carcinoma; comet assay; enzyme activity; histopathology; lipoic acid; malondialdehyde; mice; oxidative stress; superoxide dismutase; tissues; transmission electron microscopy
- Abstract:
- ... To evaluate the relationship between oxidative stress, DNA damage, and suppression of tumor growth induced by lipoic acid free and nano-capsule. Lipoic acid nano-capsule was assessed by transmission electron microscopy (TEM). The antitumor activity of lipoic acid free and nano-capsule was investigated in Ehrlich solid tumor bearing mice. The endpoints measured were superoxide dismutase (SOD) enzym ...
- DOI:
- 10.1007/s11033-019-04769-9
- https://doi.org/10.1007/s11033-019-04769-9
- Author:
- Shiwei Xu; Yanting Shen; Jingwen Xu; Guangyan Qi; Gengjun Chen; Weiqun Wang; Xiuzhi Sun; Yonghui Li
- Source:
- Journal of functional foods 2019 v.58 pp. 374-382
- ISSN:
- 1756-4646
- Subject:
- antineoplastic activity; antioxidant activity; antioxidants; cell growth; emulsions; food industry; fractionation; ground meat; hepatoma; human cell lines; hydrolysates; hydrolysis; kafirins; lipid peroxidation; oxidation; peptides; reversed-phase high performance liquid chromatography; turbidity; ultrafiltration
- Abstract:
- ... Peptide antioxidants are becoming increasingly popular in the food industry. This study reported antioxidant and anticancer properties of papain-hydrolyzed sorghum kafirin. The optimum hydrolysis conditions were determined to be 360 kU/g enzyme-to-substrate ratio, and 4 h of reaction time. After ultrafiltration, the 1–3 kDa hydrolysate fraction demonstrating promising antioxidative activities as w ...
- DOI:
- 10.1016/j.jff.2019.05.016
- https://doi.org/10.1016/j.jff.2019.05.016
- Author:
- Sael Casas-Grajales; Erika Ramos-Tovar; Esmeralda Chávez-Estrada; Diana Alvarez-Suarez; Erika Hernández-Aquino; Karina Reyes-Gordillo; Carlos M. Cerda-García-Rojas; Javier Camacho; Víctor Tsutsumi; M. Raj Lakshman; Pablo Muriel
- Source:
- Life sciences 2019 v.224 pp. 187-196
- ISSN:
- 0024-3205
- Subject:
- Stevia rebaudiana; Toll-like receptors; antineoplastic activity; antioxidant activity; antioxidants; coculture; cytokines; ethanol; gene expression regulation; genes; immune response; immunomodulators; inflammation; laboratory animals; leaves; lipopolysaccharides; liver; males; protein synthesis; rats; stevioside; transcription factor NF-kappa B; tumor necrosis factor receptors
- Abstract:
- ... Stevioside is a diterpenoid obtained from the leaves of Stevia rebaudiana (Bertoni) that exhibits antioxidant, antifibrotic, antiglycemic and anticancer properties. Therefore, we aimed to study whether stevioside has beneficial effects in liver injury induced by long-term thioacetamide (TAA) administration and investigated the possible underlying molecular mechanism using in vivo, in vitro and in ...
- DOI:
- 10.1016/j.lfs.2019.03.035
- PubMed:
- 30890404
- PubMed Central:
- PMC6556435
- https://doi.org/10.1016/j.lfs.2019.03.035
- Author:
- Peng Liu; Wei Wang; Jonathan Tang; Richard P. Bowater; Yongping Bao
- Source:
- Food and chemical toxicology 2019 v.128 pp. 129-136
- ISSN:
- 0278-6915
- Subject:
- DNA damage; antineoplastic activity; antioxidant activity; cell death; cell viability; clinical trials; enzymes; glutathione; hepatocytes; hepatoma; human cell lines; humans; hydrogen peroxide; neoplasm cells; protective effect; risk; sulforaphane; toxicity; toxicology
- Abstract:
- ... Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocytes (HHL5) and hepatoma (HepG2) cells. Results showed that SFN inhibited cell viability and induced DNA strand breaks at high doses (≥20 μM). It also activated the nuclear factor (erythroid-derived 2)-l ...
- DOI:
- 10.1016/j.fct.2019.03.050
- https://doi.org/10.1016/j.fct.2019.03.050
- Author:
- Abeer Y. Ibrahim; Samah A. El-Newary; Gamil E. Ibrahim
- Source:
- Annals of agricultural science 2019 v.64 no.1 pp. 29-37
- ISSN:
- 0570-1783
- Subject:
- Cordia dichotoma; alkaloids; alpha-phellandrene; alpha-terpineol; antineoplastic activity; antineoplastic agents; antioxidant activity; ascites; body weight; bornyl acetate; butyrates; carcinoma; catechin; chemical composition; cytotoxicity; dose response; fructose; fruit pulp; fruits; gallic acid; gas chromatography-mass spectrometry; glucose; hematologic tests; high performance liquid chromatography; ions; lethal dose 50; longevity; metals; mice; phenols; quercetin; sucrose; superoxide anion; tannins; volatile compounds
- Abstract:
- ... The aim of the present research was to investigate the chemical composition, antioxidant and anti-tumor effects of Cordia dichotoma fruit pulp extract “CDFP-extract”. Day after intraperitoneal inoculation of Ehrlich ascites carcinoma (EAC) cells in mice, CDFP-extract was administered orally at 500 mg/kg body weight (equal to 0.10 of determined LD50) for ten consecutive days. CDFP-extract contains ...
- DOI:
- 10.1016/j.aoas.2019.05.008
- https://doi.org/10.1016/j.aoas.2019.05.008
- Author:
- Chan-Su Rha; Hyun Woo Jeong; Saitbyul Park; Siyoung Lee; Young Sung Jung; Dae-Ok Kim
- Source:
- Antioxidants 2019 v.8 no.8 pp. -
- ISSN:
- 2076-3921
- Subject:
- adenoma; antineoplastic activity; antioxidant activity; apigenin; breast neoplasms; cell lines; colon; dose response; endo-1,4-beta-glucanase; flavanols; gene expression; genes; glycosides; green tea; kaempferol; macrophages; mass spectrometry; messenger RNA; mice; models; myricetin; neoplasm cells; oxidative stress; paclitaxel; quercetin; tannase; viability
- Abstract:
- ... (1) Background: Extensive research has focused on flavan-3-ols, but information about the bioactivities of green tea flavonols is limited. (2) Methods: In this study, we investigated the antioxidative, anti-inflammatory, and anticancer effects of flavonol glycosides and aglycones from green tea using in vitro cell models. The fractions rich in flavonol glycoside (FLG) and flavonol aglycone (FLA) w ...
- DOI:
- 10.3390/antiox8080278
- PubMed:
- 31387266
- PubMed Central:
- PMC6719943
- https://doi.org/10.3390/antiox8080278
- Author:
- Sherien K. Hassan; Amria M. Mousa; Nermin M. El-Sammad; Abeer H. Abdel-Halim; Wagdy K.B. Khalil; Elsayed A. Elsayed; Nayera Anwar; Michael W. Linscheid; Eman S. Moustafa; Amani N. Hashim; Mahmoud Nawwar
- Source:
- Toxicology reports 2019 v.6 pp. 1071-1085
- ISSN:
- 2214-7500
- Subject:
- Cuphea ignea; albino; antineoplastic activity; antioxidant activity; blood serum; body weight; carcinogenesis; caspase-3; chemoprevention; cytotoxicity; histopathology; humans; lipid peroxidation; lung neoplasms; lungs; metalloproteinases; mice; mortality; neoplasm cells; oral administration; toxicology
- Abstract:
- ... Lung cancer has one of the highest mortality rates among various types of cancer and is the most frequent cancer in the world. The incidence of lung cancer is increasing rapidly, in parallel with an increased incidence of smoking. Effective chemoprevention may be an alternative strategy to control the incidence of lung cancer. Thus, the objective of current work was to ascertain the possible preve ...
- DOI:
- 10.1016/j.toxrep.2019.10.004
- https://doi.org/10.1016/j.toxrep.2019.10.004
- Author:
- Nik Mohd Afizan Nik Abd Rahman; M. Y. Nurliyana; M. N. F. Natasha Nur Afiqah; Mohd Azuraidi Osman; Muhajir Hamid; Mohd Azmi Mohd Lila
- Source:
- BMC complementary and alternative medicine 2019 v.19 no.1 pp. 340
- ISSN:
- 1472-6882
- Subject:
- Clinacanthus nutans; adverse effects; alternative medicine; animal disease models; antineoplastic activity; antioxidant activity; apoptosis; blood serum; bone marrow; breast neoplasms; chemical constituents of plants; cytokines; enzyme-linked immunosorbent assay; eosin; grasses; inflammation; liver; lungs; malondialdehyde; methanol; mitosis; nitric oxide; plant extracts; snakes; splenocytes; Borneo; Malaysia
- Abstract:
- ... BACKGROUND: Clinacanthus nutans Lindau (C. nutans) is a species of in Acanthaceae family and primarily used in South East Asian countries. C. nutans is well known as Sabah snake grass in Malaysia, and its leaves have diverse medicinal potential in conventional applications, including cancer treatments. On the basis of literature search, there is less conclusive evidence of the involvement of phyto ...
- DOI:
- 10.1186/s12906-019-2757-4
- PubMed:
- 31783838
- PubMed Central:
- PMC6884788
- https://doi.org/10.1186/s12906-019-2757-4
- Author:
- Ebru Demirel Sezer; Latife Merve Oktay; Elif Karadadaş; Hikmet Memmedov; Nur Selvi Gunel; Eser Sözmen
- Source:
- Journal of medicinal food 2019 v.22 no.11 pp. 1118-1126
- ISSN:
- 1557-7600
- Subject:
- 2,5-dihydroxybenzoic acid; Vaccinium myrtillus; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; blueberries; cytotoxicity; diet; flow cytometry; fruit extracts; kaempferol; liquid chromatography; neoplasms; oxidants; oxidative stress; polyphenols; protein composition; protein microarrays; proteins; quercetin; tandem mass spectrometry; therapeutics
- Abstract:
- ... In recent years, natural products gained popularity with their anti-inflammatory and antioxidant effects mediated by chemical compounds within their composition. Study results offering them as palliative therapy options in cancer or as anticancer agents with high levels of cytotoxicity brought a new approach to combine cancer treatment protocols with these products. From a different perspective, e ...
- DOI:
- 10.1089/jmf.2019.0098
- https://doi.org/10.1089/jmf.2019.0098
- Author:
- Tsvetelina Batsalova; Diyana Basheva; Krum Bardarov; Ventzislav Bardarov; Balik Dzhambazov; Ivanka Teneva
- Source:
- Chemosphere 2019 v.218 pp. 93-103
- ISSN:
- 0045-6535
- Subject:
- Fischerella; active ingredients; antibiotics; antifungal properties; antineoplastic activity; antioxidant activity; antioxidants; cell culture; cell lines; cytotoxicity; environmental assessment; environmental impact; exposure duration; hormones; human health; immunosuppressive agents; in vitro studies; insecticides; microcystins; photosynthesis; repellents; risk assessment; saxitoxins; vitamins
- Abstract:
- ... Cyanoprokaryotes (Cyanobacteria/Cyanophyta) are ancient photosynthetic prokaryotic organisms with cosmopolitan distribution. They are producers of a number of biologically active substances with antitumor and antifungal activity, vitamins, antibiotics, algaecides, insecticides, repellents, hormones, immunosuppressants and toxins. So far, the cyanobacterium Fischerella major Gomont has not been stu ...
- DOI:
- 10.1016/j.chemosphere.2018.11.097
- https://doi.org/10.1016/j.chemosphere.2018.11.097