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You searched for: Publication Year 2019 Remove constraint Publication Year: 2019 Subject antineoplastic activity Remove constraint Subject: antineoplastic activity Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. 16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity in vivo and in vitro

Author:
Yiren Yang; Liping Long; Xinxin Zhang; Kairu Song; Da Wang; Xin Xiong; Huiyuan Gao; Luping Sha
Source:
RSC advances 2019 v.9 no.54 pp. 31758-31772
ISSN:
2046-2069
Subject:
antineoplastic activity; apoptosis; breasts; doxorubicin; glycosides; hemolysis; human cell lines; humans; hydrolysates; lungs; metastasis; mice; neoplasm cells; neoplasm progression; toxicity; triterpenoids; uterine cervical neoplasms
Abstract:
... Barrigenol-like triterpenoids (BATs) showed promising anti-tumor, anti-inflammatory and anti-Alzheimer's activities, while, the inhibitory strength was usually affected by their states with aglycones or glycosides. In order to find more BATs as new anti-tumor agents with much more efficiency, the chemical and pharmaceutical studies were carried out on the acid hydrolysate product (AHP) of Semen Ae ...
DOI:
10.1039/c9ra06015d

2. 1‐O‐alkylglycerols from the hepatopancreas of the crab Paralithodes camtschaticus, liver of the squid Berryteuthis magister, and liver of the skate Bathyraja parmifera, and their anticancer activity on human melanoma cells

Author:
Nikolay A. Latyshev; Svetlana P. Ermakova; Ekaterina V. Ermolenko; Andrey B. Imbs; Sergey P. Kasyanov; Ruslan M. Sultanov
Source:
Journal of food biochemistry 2019 v.43 no.5 pp. e12828
ISSN:
0145-8884
Subject:
Bathyraja; Paralithodes camtschatica; antineoplastic activity; aquatic organisms; crabs; cytotoxicity; hepatopancreas; human cell lines; inhibitory concentration 50; lipids; liver; melanoma; squid; therapeutics
Abstract:
... 1‐O‐alkylglycerols (AKG) are a class of natural ether lipids derived from 1‐O‐alkyl‐2,3‐diacyl‐sn‐glycerols by deacylation. In this study, 1‐O‐alkylglycerol (AKG) composition was investigated in the hepatopancreas lipids of the crab Paralithodes camtschaticus and the liver lipids of the squid Berryteuthis magister and the skate Bathyraja parmifera. One of the principal AKG in marine organisms was ...
DOI:
10.1111/jfbc.12828

3. 2-Methylpyridine-1-ium-1-sulfonate as an Inducer of Apoptosis and Cell Cycle Arrest: A comparative in vitro and Computational Study

Author:
Hamid-Reza Mohammadi-Motlagh; Reza Yarani; Mona Sadeghalvad; Elham Adham; Hassan Rasouli; Ali Mostafaie
Source:
Nutrition and cancer 2019 v.71 no.4 pp. 643-656
ISSN:
1532-7914
Subject:
Allium; DNA fragmentation; antineoplastic activity; apoptosis; bulbs; cell cycle checkpoints; computer simulation; cyclins; dose response; gastrointestinal neoplasms; human cell lines; mechanism of action; medicinal plants; medicine; neoplasm cells; phosphotransferases (kinases)
Abstract:
... “Let food be thy medicine and thy medicine be thy food” was expressed by Hippocrates and the health benefits of medicinal plants and natural products have been considered by humans since historic times. The current study aims to investigate the anti-cancer activity of 2-Methylpyridine-1-ium-1-sulfonate (MPS) isolated from bulbs of Allium hirtifolium. The MPS compound (in a dose-dependent manner) i ...
DOI:
10.1080/01635581.2018.1506495

4. 2′-Hydroxyflavanone induced changes in the proteomic profile of breast cancer cells

Author:
Lokesh D. Nagaprashantha; Jyotsana Singhal; Shireen Chikara; Gabriel Gugiu; David Horne; Sanjay Awasthi; Ravi Salgia; Sharad S. Singhal
Source:
Journal of proteomics 2019 v.192 pp. 233-245
ISSN:
1874-3919
Subject:
antineoplastic activity; antineoplastic agents; breast neoplasms; breasts; citrus fruits; epithelial cells; flavonoids; metastasis; neoplasm cells; proteins; proteomics; therapeutics; women
Abstract:
... In spite of rapid advances in understanding of signaling networks associated with the incidence and therapeutic-sensitivity, breast cancer (BC) still remains the most commonly diagnosed and prevalent cancer in women. Emergence of resistance to hormonal interventions in estrogen-receptor (ER) positive BC coupled to loss of ER expression and activation of ER-independent growth factor, heat-shock, MY ...
DOI:
10.1016/j.jprot.2018.09.005

5. 3‐Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau

Author:
Young H. Ko; Katarzyna Niedźwiecka; Margarida Casal; Peter L. Pedersen; Stanisław Ułaszewski
Source:
Yeast 2019 v.36 no.4 pp. 211-221
ISSN:
0749-503X
Subject:
Cryptococcus neoformans; adenosine triphosphate; adverse effects; algae; animal models; antimicrobial properties; antineoplastic activity; apoptosis; bromination; cancer therapy; cell movement; fungi; glucose; glycolysis; hexokinase; lactic acid; mitochondria; neoplasm cells; neoplasms; oxygen; patients; pumps; pyruvic acid; transporters
Abstract:
... 3‐Bromopyruvate (3BP) is a small, highly reactive molecule formed by bromination of pyruvate. In the year 2000, the antitumor properties of 3BP were discovered. Studies using animal models proved its high efficacy for anticancer therapy with no apparent side effects. This was also found to be the case in a limited number of cancer patients treated with 3BP. Due to the “Warburg effect,” most tumor ...
DOI:
10.1002/yea.3367

6. 3′‐Desmethylarctigenin induces G2/M cell cycle arrest and apoptosis through reactive oxygen species generation in hepatocarcinoma cells

Author:
Enxiang Zhang; Xiuling Wang; Xiaoyi Liu; Min Liang; Hongbo Hu; Shutao Yin
Source:
Phytotherapy research 2019 v.33 no.12 pp. 3218-3227
ISSN:
0951-418X
Subject:
antineoplastic activity; apoptosis; cell cycle checkpoints; chemoprevention; hepatoma; human cell lines; mice; mitochondria; models; reactive oxygen species; therapeutics; toxicity
Abstract:
... Previous studies have shown that arctigenin is a promising chemopreventive or therapeutic agent against various cancers. However, less is known about anticancer activity of 3′‐desmethylarctigenin (3′‐DMAG), which is a biotransformed product from arctigenin or arctin. In this study, we compared the anticancer activity of 3′‐DMAG with its parent compound arctigenin and demonstrated that 3′‐DMAG exer ...
DOI:
10.1002/ptr.6496

7. 4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer

Author:
Zhicong Zhao; Dongsheng Shang; Lipeng Qiu; Chang Guo; Yanyan Li; Hanqing Liu; Guoyue Yuan; Zhigang Tu
Source:
Life sciences 2019 v.238 pp. 116973
ISSN:
0024-3205
Subject:
DNA damage; antineoplastic activity; antineoplastic agents; cell senescence; drug therapy; enzymes; fluorescent antibody technique; heterocyclic nitrogen compounds; in vitro studies; in vivo studies; mice; screening; signal transduction; staining; stomach neoplasms; survival rate
Abstract:
... Gastric cancer (GC) is a common cancer with a relatively low survival rate. Cellular senescence, a potent anti-cancer mechanism, is naturally occurred, and can be induced by chemotherapeutic agents. We sought to explore new compounds against GC cells by inducing cellular senescence.Primary screening of a library of N-heterocyclic compounds identified some with potent inhibitory effects on GC cells ...
DOI:
10.1016/j.lfs.2019.116973

8. 5-Acetamido-1-(methoxybenzyl) isatin inhibits tumor cell proliferation, migration, and angiogenesis

Author:
Qian Zhang; Ying Fu; Yufan Zhao; Shanshan Cui; Jing Wang; Fengxi Liu; Yuan Yuan; Hervé Galons; Peng Yu; Yuou Teng
Source:
RSC advances 2019 v.9 no.63 pp. 36690-36698
ISSN:
2046-2069
Subject:
angiogenesis; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cell proliferation; chemotaxis; cyclins; flow cytometry; human umbilical vein endothelial cells; humans; indoles; liver neoplasms; mitochondria; neoplasm cells
Abstract:
... Indole and its derivatives are widely distributed in both animals and plants. Among its array of biological activities, the anti-tumor activity of indole has garnered much attention. Furthermore, the synthesis and activity of indole derivatives, including isatin, constitute a flourishing research topic. Previously, many isatin derivatives were synthesized by our group, and 5-acetamido-1-(methoxybe ...
DOI:
10.1039/c9ra07002h

9. 5-Fluorouracil-loaded β-cyclodextrin-carrying polymeric poly(methylmethacrylate)-coated samarium ferrite nanoparticles and their anticancer activity

Author:
M. S. Hariharan; R. Sivaraj; S. Ponsubha; R. Jagadeesh; I. V. M. V. Enoch
Source:
Journal of materials science 2019 v.54 no.6 pp. 4942-4951
ISSN:
0022-2461
Subject:
antineoplastic activity; beta-cyclodextrin; cytotoxicity; energy-dispersive X-ray analysis; ferrimagnetic materials; fluorouracil; magnetic fields; magnetic properties; nanocarriers; nanoparticles; neoplasms; polymers; samarium; spectroscopy
Abstract:
... Drug-loading on magnetic nanoparticles coated with biocompatible polymers are intriguing nanostructures for targeted delivery of anticancer drugs with the application of a magnetic field. In this paper, we report the preparation of SmFeO₃ nanoparticles and loading of the anticancer drug 5-fluorouracil on the carrier by forming host–guest complex with β-cyclodextrin. The material and the polymer ar ...
DOI:
10.1007/s10853-018-3161-z

10. 7-O-geranylquercetin contributes to reverse P-gp-mediated adriamycin resistance in breast cancer

Author:
Enxia Zhang; Jiasi Liu; Lei Shi; Xin Guo; Ze Liang; Jiaxin Zuo; Hong Xu; Huaxin Wang; Xiaohong Shu; Shanshan Huang; Shubiao Zhang; Xiaohui Kang; Yuhong Zhen
Source:
Life sciences 2019 v.238 pp. 116938
ISSN:
0024-3205
Subject:
P-glycoproteins; Western blotting; antineoplastic activity; breast neoplasms; caudal vein; computer simulation; doxorubicin; drug resistance; drug therapy; flow cytometry; fluorescence microscopes; fluorescence microscopy; gene expression regulation; genes; mice; molecular models; quantitative polymerase chain reaction; quercetin; rhodamines; tissues; toxicity testing; viability
Abstract:
... To investigate the effect of 7-O-geranylquercetin (GQ), a derivative of quercetin (Q), on reversing drug resistance in breast cancer MCF-7/ADR cells and reveal the mechanisms related to P-glycoprotein (P-gp).Cell viability was determined by MTT assay. Accumulation of adriamycin (ADR) in cells was determined by confocal fluorescence microscope and microplate reader while that of rhodamine (Rh) was ...
DOI:
10.1016/j.lfs.2019.116938

11. AKT1-targeted proapoptotic activity of compound K in human breast cancer cells

Author:
Eunju Choi; Eunji Kim; Ji Hye Kim; Keejung Yoon; Sunggyu Kim; Jongsung Lee; Jae Youl Cho
Source:
Journal of Ginseng Research 2019 v.43 no.4 pp. 692-698
ISSN:
1226-8453
Subject:
Panax; antineoplastic activity; apoptosis; breast neoplasms; cancer therapy; caspase-7; caspase-8; caspase-9; cell viability; death; disease severity; flow cytometry; humans; immunoblotting; intestines; metabolites; neoplasm cells; propidium; research; saponins
Abstract:
... Breast cancer is a severe disease and the second leading cause of cancer death in women worldwide. To surmount this, various diagnosis and treatment options for breast cancer have been developed. One of the most effective strategies for cancer treatment is to induce apoptosis using naturally occurring compounds. Compound K (CK) is a ginseng saponin metabolite generated by human intestinal bacteria ...
DOI:
10.1016/j.jgr.2019.07.001

12. Acacetin‐induced cell apoptosis in head and neck squamous cell carcinoma cells: Evidence for the role of muscarinic M3 receptor

Author:
Fenglin Sun; Duo Li; Cong Wang; Caixia Peng; Hong Zheng; Xiaofeng Wang
Source:
Phytotherapy research 2019 v.33 no.5 pp. 1551-1561
ISSN:
0951-418X
Subject:
antineoplastic activity; apoptosis; calcium; calcium signaling; caspase-3; caspase-9; cell lines; cell viability; cytochrome c; electron microscopy; flavones; flow cytometry; mitochondria; neoplasm cells; small interfering RNA; squamous cell carcinoma
Abstract:
... Aacacetin, a plant flavone has shown antitumor efficacy recently. However, its associated mechanisms are poorly known. We hypothesized that the muscarinic M3 receptor (M₃R), which is highly expressed in some cancer tissue, is related to the antitumor effect of acacetin in head and neck squamous cell carcinoma (HNSCC) cells. Our results showed that 12.5‐ to 200‐μM acacetin inhibited cell viability ...
DOI:
10.1002/ptr.6343

13. Achieving traceless ablation of solid tumors without recurrence by mild photothermal-chemotherapy of triple stimuli-responsive polymer–drug conjugate nanoparticles

Author:
Chang Du; Yue Ding; Jiwen Qian; Rong Zhang; Chang-Ming Dong
Source:
Journal of materials chemistry B 2019 v.7 no.3 pp. 415-432
ISSN:
2050-7518
Subject:
animals; antineoplastic activity; blood circulation; burning; drugs; fever; fluorescence; image analysis; intravenous injection; irradiation; nanoparticles; near-infrared spectroscopy; neoplasm cells; neoplasms; pH; pharmacokinetics; photothermotherapy
Abstract:
... Although photothermal therapy (PT) and photothermal-chemotherapy (PT-CT) treatments have been used to achieve complete ablation of solid tumors, they are often implemented at more than 50 °C under high intensity and using a high dose of NIR irradiation, concomitantly inducing heavy skin burning, tissue damage, and ugly scarring. Moreover, the residual tumor cells at the treated site cannot be comp ...
DOI:
10.1039/c8tb02432d

14. Acid and light stimuli-responsive mesoporous silica nanoparticles for controlled release

Author:
Mingdong Wang; Ting Wang; Dong Wang; Wei Jiang; Jiajun Fu
Source:
Journal of materials science 2019 v.54 no.8 pp. 6199-6211
ISSN:
0022-2461
Subject:
alpha-cyclodextrin; antineoplastic activity; breast neoplasms; doxorubicin; encapsulation; humans; hydrazones; irradiation; mechanization; nanoparticles; neoplasm cells; pH; porous media; silica; ultraviolet radiation
Abstract:
... We constructed a novel stimuli-responsive system, MSNPs 1, based on mechanized silica nanoparticles, in which mesoporous silica nanoparticles (MSNs) acted as nanocontainers to load cargo, and supramolecular switches consisting of hydrazone bond, azobenzene and α-cyclodextrin (α-CD) realized the controlled release of cargo molecules from MSNPs 1. In neutral solution and without UV light irradiation ...
DOI:
10.1007/s10853-019-03325-x

15. Actinidia arguta (Hardy Kiwi) Root Extract Exerts Anti-cancer Effects via Mcl-1-Mediated Apoptosis in Cholangiocarcinoma

Author:
Xiangxuan Zhao; Feng Wen; Wei Wang; Zaiming Lu; Qiyong Guo
Source:
Nutrition and cancer 2019 v.71 no.2 pp. 246-256
ISSN:
1532-7914
Subject:
Actinidia arguta; NAD ADP-ribosyltransferase; Western blotting; antineoplastic activity; apoptosis; caspase-3; caspase-8; cell lines; cell viability; ethanol; growth retardation; liver; mice; neoplasms; patients; tissues
Abstract:
... Cholangiocarcinoma (CCA) is a highly aggressive and chemoresistant liver malignancy. Thus, identification of strategies to overcome insensitivity to apoptosis and growth inhibition is a growing focus of research in this malignancy. This study evaluated the potential anti-cancer effects of an ethanol extract from the Actinidia arguta (Hardy Kiwi) root (RAE) on CCA. Our data demonstrated that RAE de ...
DOI:
10.1080/01635581.2018.1557218

16. Actinidia chinensis Planch root extract attenuates proliferation and metastasis of hepatocellular carcinoma by inhibiting epithelial-mesenchymal transition

Author:
Tingting Fang; Yuan Fang; Xiaojing Xu; Mingyan He; Zhiying Zhao; Peixin Huang; Feifei Yuan; Mengzhou Guo; Biwei Yang; Jinglin Xia
Source:
Journal of ethnopharmacology 2019 v.231 pp. 474-485
ISSN:
0378-8741
Subject:
Actinidia chinensis; Oriental traditional medicine; animal models; antineoplastic activity; apoptosis; cell proliferation; cell viability; cytotoxicity; diuresis; gene expression; gene expression regulation; genes; hemostasis; hepatoma; herbs; messenger RNA; metastasis; patients; prognosis; quantitative polymerase chain reaction
Abstract:
... Numerous studies have demonstrated the potent anticancer activity of various Chinese herbs. Actinidia chinensis Planch root (acRoots), a traditional Chinese medicine, functions as an antitumor and detoxifying agent and plays a role in diuresis and hemostasis. Treatment with acRoots confers strong inhibition of tumor growth in various forms of cancer. Here, we evaluated the anticancer activity and ...
DOI:
10.1016/j.jep.2018.11.014

17. Activated TNF-α/RIPK3 signaling is involved in prolonged high fat diet-stimulated hepatic inflammation and lipid accumulation: inhibition by dietary fisetin intervention

Author:
Minxuan XuThese authors contributed equally to this work.; Chenxu Ge; Yuting Qin; Tingting Gu; Jinxiao Lv; Sujun Wang; Yongjie Ma; Deshuai Lou; Qiang Li; Linfeng Hu; Xuyuan Nie; Mingxing Wang; Ping Huang; Jun Tan
Source:
Food & function 2019 v.10 no.3 pp. 1302-1316
ISSN:
2042-650X
Subject:
antineoplastic activity; blood serum; fatty liver; flavonoids; gene expression; gene expression regulation; high fat diet; inflammation; lipids; liver; liver function; metabolic diseases; metabolic syndrome; mice; neoplasms; polyphenols; protective effect; protein kinases; tumor necrosis factor-alpha
Abstract:
... Increasing evidence indicates that high-fat diet (HFD) is a predisposing factor for metabolic syndrome-associated systemic inflammation and nonalcoholic fatty liver disease (NAFLD). Tumor necrosis factor-α/receptor-interacting protein kinase 3 (TNF-α/RIPK3) axis has recently become regarded as an important regulator and contributor in many inflammation-related diseases. Fisetin (Fn) is a bioactive ...
DOI:
10.1039/c8fo01615a

18. Activity of antibacterial compounds from Bacillus subtilis against cellular oncoproteins by in silico approach

Author:
Annadurai Vinothkanna; Premkumar Palanisamy; Soundarapandian Sekar
Source:
Biocatalysis and agricultural biotechnology 2019 v.18 pp. 101059
ISSN:
1878-8181
Subject:
Bacillus subtilis; antibiotics; antineoplastic activity; bacteria; caspase-3; caspase-8; databases; drugs; hydrogen bonding; neoplasms; oncogene proteins; transcription factor NF-kappa B
Abstract:
... The cellular oncoproteins Caspase-3, Caspase-8 and Nuclear Factor-kappa B (NF-κB) are the factors implicated in several cancers. Synthetic and natural compounds were demonstrated to interact with these oncoproteins. Though bacteria are the source of novel compounds including antimicrobial compounds, their anticancer activity remains elusive. Hence in this study, 10 antibacterial compounds of Bacil ...
DOI:
10.1016/j.bcab.2019.101059

19. Ad5-EMC6 mediates antitumor activity in gastric cancer cells through the mitochondrial apoptosis pathway

Author:
Riyong Li; Xiaokun Wang; Xuan Zhang; Jiahong Yu; Jinqiu Feng; Ping Lv; Yaxin Lou; Yingyu Chen
Source:
Biochemical and biophysical research communications 2019 v.513 no.3 pp. 663-668
ISSN:
0006-291X
Subject:
antineoplastic activity; apoptosis; carcinogenesis; cell growth; drug therapy; endoplasmic reticulum; etoposide; membrane potential; mice; mitochondria; mitochondrial membrane; models; neoplasm cells; stomach neoplasms; transmembrane proteins
Abstract:
... Endoplasmic reticulum membrane protein complex subunit 6 (EMC6), also known as transmembrane protein 93 (transmembrane protein 93, TMEM93), is an autophagy-related protein. EMC6 overexpression inhibits cancer cell growth and induces apoptosis, but the interaction partners of EMC6 and its cellular responsibilities remain incompletely understood. In this study, we report that adenovirus-mediated ect ...
DOI:
10.1016/j.bbrc.2019.04.023

20. Advances in phytochemical delivery systems for improved anticancer activity

Author:
Ricardo Lagoa; João Silva; Joaquim Rui Rodrigues; Anupam Bishayee
Source:
Biotechnology advances 2019 pp. -
ISSN:
0734-9750
Subject:
antineoplastic activity; berberine; bioavailability; chemical constituents of plants; colon; curcumin; drug delivery systems; flavonoids; nanoemulsions; nanoparticles; neoplasms; nose; pharmacokinetics; resveratrol
Abstract:
... Natural compounds have significant anticancer pharmacological activities, but often suffer from low bioavailability and selectivity that limit therapeutic use. The present work critically analyzes the latest advances on drug delivery systems designed to enhance pharmacokinetics, targeting, cellular uptake and efficacy of anticancer phytoconstituents. Various phytochemicals, including flavonoids, r ...
DOI:
10.1016/j.biotechadv.2019.04.004

21. AgBiS₂-TPP nanocomposite for mitochondrial targeting photodynamic therapy, photothermal therapy and bio-imaging under 808 nm NIR laser irradiation

Author:
Mingdi Sun; Dan Yang; Chen Wang; Huiting Bi; Yuan Zhou; Xiangxi Wang; Jiating Xu; Fei He; Shili Gai; Piaoping Yang
Source:
Biomaterials science 2019 v.7 no.11 pp. 4769-4781
ISSN:
2047-4849
Subject:
antineoplastic activity; bioimaging; computed tomography; energy; irradiation; mitochondria; nanocomposites; nanoparticles; near infrared radiation; near-infrared spectroscopy; neoplasm cells; neoplasms; patients; photochemotherapy; photothermotherapy; population growth; precision medicine; reactive oxygen species; sulfides
Abstract:
... 808 nm near-infrared (NIR) light-induced biological theranostics is gradually becoming a popular method for cancer treatment. Meanwhile, mild synthetic methods to prepare medicines and gentle treatment conditions for cancer patients are becoming increasingly important to oncotherapy. Herein, tiny AgBiS₂ nanodots were synthesized via a simple method, and for the first time, discovered to produce a ...
DOI:
10.1039/c9bm01077g

22. Ailanthone inhibits cell growth and migration of cisplatin resistant bladder cancer cells through down-regulation of Nrf2, YAP, and c-Myc expression.

Author:
Martina Daga; Stefania Pizzimenti; Chiara Dianzani; Marie Angele Cucci; Roberta Cavalli; Margherita Grattarola; Benedetta Ferrara; Valentina Scariot; Francesco Trotta; Giuseppina Barrera
Source:
Phytomedicine 2019 v.56 pp. 156-164
ISSN:
0944-7113
Subject:
Ailanthus altissima; Western blotting; active ingredients; antibodies; antineoplastic activity; apoptosis; bladder; cell growth; cell lines; cell movement; cisplatin; cortex; essential genes; flow cytometry; gene expression; humans; interphase; neoplasm cells; protein synthesis; staining; therapeutics; tissue repair; toxicity; urinary bladder neoplasms
Abstract:
... Ailanthone (Aila) is a natural active compound isolated from the Ailanthus altissima, which has been shown to possess an “in vitro” growth-inhibitory effect against several cancer cell lines. Advanced bladder cancer is a common disease characterized by a frequent onset of resistance to cisplatin-based therapy. The cisplatin (CDDP) resistance is accompanied by an increase in Nrf2 protein expression ...
DOI:
10.1016/j.phymed.2018.10.034

23. An Alcohol-Soluble Polysaccharide from Atractylodes macrocephala Koidz Induces Apoptosis of Eca-109 cells

Author:
Ying-ying Feng; Hai-yu Ji; Xiao-dan Dong; An-jun Liu
Source:
Carbohydrate polymers 2019 pp. -
ISSN:
0144-8617
Subject:
Atractylodes macrocephala; Fourier transform infrared spectroscopy; Western blotting; antineoplastic activity; apoptosis; arabinose; dyes; esophageal neoplasms; gas chromatography; gel chromatography; glucose; glycosidic linkages; interphase; mitochondria; polysaccharides; rhodamines; staining; therapeutics
Abstract:
... In this study, polysaccharides from Atractylodes macrocephala Koidz (APA) which were soluble in alcohol were prepared, purified, analyzed the structure and investigated the antitumor activity in vitro cell experiment. Results of high-performance gel permeation chromatography (HPGPC), fourier-transform infrared spectroscopy (FT-IR), and gas chromatography (GC) showed that APA was a 2.1KDa neutral h ...
DOI:
10.1016/j.carbpol.2019.115136

24. Alcohol-soluble polysaccharide from Castanea mollissima blume: Preparation, characteristics and antitumor activity

Author:
Xiao-dan Dong; Juan Yu; Ying-ying Feng; Hai-yu Ji; Sha-Sha Yu; An-jun Liu
Source:
Journal of functional foods 2019 v.63 pp. 103563
ISSN:
1756-4646
Subject:
Castanea mollissima; Fourier transform infrared spectroscopy; antineoplastic activity; apoptosis; blood serum; cell cycle; galactose; glucose; glycosidic linkages; immune response; interferon-gamma; interleukin-2; macrophages; mice; natural killer cells; neoplasm cells; polysaccharides; staining; tumor necrosis factor-alpha; uronic acids
Abstract:
... CMBP was an alcohol-soluble polysaccharide extracted from Castanea mollissima blume. Our study aimed to investigate the preliminary structural characteristics and in vivo antitumor activity of CMBP. The contents of total sugar, protein and uronic acid in CMBP was 93.68%, 0.89% and 1.78%, respectively. GC and FTIR results suggested galactose and glucose were detected for CMBP (2.86 × 103 Da), while ...
DOI:
10.1016/j.jff.2019.103563

25. Algae metabolites: from in vitro growth inhibitory effects to promising anticancer activity

Author:
Florence Lefranc; Aikaterini Koutsaviti; Efstathia Ioannou; Alexander Kornienko; Vassilios Roussis; Robert Kiss; David Newman
Source:
Natural product reports 2019 v.36 no.5 pp. 810-841
ISSN:
1460-4752
Subject:
algae; antineoplastic activity; autotrophs; drug therapy; marine environment; metabolites; metastasis; models; neoplasm cells; neoplasms; signal transduction; transporters
Abstract:
... Covering: 1957 to 2017 Algae constitute a heterogeneous group of eukaryotic photosynthetic organisms, mainly found in the marine environment. Algae produce numerous metabolites that help them cope with the harsh conditions of the marine environment. Because of their structural diversity and uniqueness, these molecules have recently gained a lot of interest for the identification of medicinally use ...
DOI:
10.1039/c8np00057c

26. Alkaloids isolated from Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae: Anticancer activity of coccinine and montanine

Author:
M. Masi; S. Van slambrouck; S. Gunawardana; M.J. van Rensburg; P.C. James; J.G. Mochel; P.S. Heliso; A.S. Albalawi; A. Cimmino; W.A.L. van Otterlo; A. Kornienko; I.R. Green; A. Evidente
Source:
South African journal of botany 2019 v.126 pp. 277-281
ISSN:
0254-6299
Subject:
Haemanthus; antineoplastic activity; bulbs; human cell lines; humans; lycorine; metabolites; neoplasm cells
Abstract:
... Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae, was studied for the first time for its alkaloid content. From the acid extract of its bulbs, albomaculine, incartine, coccinine and montanine, belonging to the lycorine-, homolycorine- and isoquinoline-type alkaloids respectively, were isolated. Coccinine was the main metabolite (1.49 g/kg) and to the best of our knowledge H. hu ...
DOI:
10.1016/j.sajb.2019.01.036

27. Allium vegetables for possible future of cancer treatment

Author:
Yahya Asemani; Nasrindokht Zamani; Maryam Bayat; Zahra Amirghofran
Source:
Phytotherapy research 2019 v.33 no.12 pp. 3019-3039
ISSN:
0951-418X
Subject:
Allium; adverse effects; ajoene; antineoplastic activity; antineoplastic agents; antioxidant activity; apoptosis; cell cycle; chives; garlic; health effects assessments; ingredients; leeks; medicinal plants; metastasis; neoplasm cells; neoplasms; quercetin; shallots; signal transduction; sulfur; therapeutics; traditional medicine
Abstract:
... Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, onions, leeks, chives, and shallots. These plants have been exploited in folk medicine because of their beneficial health effects in improving numerou ...
DOI:
10.1002/ptr.6490

28. Amino modified metal-organic frameworks as pH-responsive nanoplatforms for safe delivery of camptothecin

Author:
Alejandro Cabrera-García; Elisa Checa-Chavarria; Eva Rivero-Buceta; Victoria Moreno; Eduardo Fernández; Pablo Botella
Source:
Journal of colloid and interface science 2019 v.541 pp. 163-174
ISSN:
0021-9797
Subject:
antineoplastic activity; biocompatibility; chemical bonding; coordination polymers; cytotoxicity; drug carriers; drugs; in vitro studies; iron; pH; porous media
Abstract:
... MIL-100(Fe) and MIL-101(Fe) metal-organic frameworks (MOFs) are excellent vehicles for drug delivery systems (DDSs) due to their high biocompatibility and stability in physiological fluids, as well as their pore diameter in the mesoporous range. Although they are appropriate for the internal diffusion of 20-(S)-camptothecin (CPT), a strongly cytotoxic molecule with excellent antitumor activity, no ...
DOI:
10.1016/j.jcis.2019.01.042

29. Amphiphilic Gemini Iridium(III) Complex as a Mitochondria-Targeted Theranostic Agent for Tumor Imaging and Photodynamic Therapy

Author:
Sili Yi; Zhen Lu; Jin Zhang; Jun Wang; Zenghong Xie; Linxi Hou
Source:
ACS applied materials & interfaces 2019 v.11 no.17 pp. 15276-15289
ISSN:
1944-8252
Subject:
antineoplastic activity; diagnostic techniques; emissions factor; human cell lines; image analysis; in vivo studies; iridium; ligands; mitochondria; neoplasm cells; neoplasms; photochemotherapy; photostability; phototoxicity; quaternary ammonium compounds; singlet oxygen; spectroscopy; water solubility
Abstract:
... Clinical diagnostics and therapeutics of tumors are significantly benefitted by the development of multifunctional theranostic agents, which integrate tumor targeting, imaging, and therapeutics. However, the integration of imaging and therapy functionalities to a unimolecular framework remains a great challenge. Herein, a family of amphiphilic gemini iridium(III) complexes (GIC), Ir1–Ir6, are synt ...
DOI:
10.1021/acsami.9b01205

30. Analyses of the possible anti-tumor effect of yokukansan

Author:
Cheolsun Han; Miho Kawata; Yusuke Hamada; Takashige Kondo; Junna Wada; Katsunori Asano; Hitoshi Makabe; Katsuhide Igarashi; Naoko Kuzumaki; Michiko Narita; Hiroyuki Kobayashi; Minoru Narita
Source:
Natural medicines 2019 v.73 no.3 pp. 468-479
ISSN:
1340-3443
Subject:
analgesic effect; antineoplastic activity; blood serum; epidermal growth factor receptors; hypothalamus; in vitro studies; intestinal microorganisms; lung neoplasms; medicine; mice; microRNA; microarray technology; neoplasm progression; pellets; signal transduction; tranquilizers
Abstract:
... The Kampo medicine yokukansan (YKS) has a wide variety of properties such as anxiolytic, anti-inflammatory and analgesic effects, and is also thought to regulate tumor suppression. In this study, we investigated the anti-tumor effect of YKS. We used Lewis lung carcinoma (LLC)-bearing mice that were fed food pellets containing YKS and then performed a fecal microbiota analysis, a microarray analysi ...
DOI:
10.1007/s11418-019-01283-x

31. Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from Foeniculum vulgare from Hamedan, Iran

Author:
Maryam Akhbari; Reza Kord; Saeedeh Jafari Nodooshan; Sepideh Hamedi
Source:
Natural product research 2019 v.33 no.11 pp. 1629-1632
ISSN:
1478-6427
Subject:
Artemia; Escherichia coli; Foeniculum vulgare; Pseudomonas aeruginosa; Shigella dysenteriae; antibacterial properties; antineoplastic activity; antineoplastic agents; breast neoplasms; carcinoma; cell lines; death; essential oils; gas chromatography-mass spectrometry; humans; inhibitory concentration 50; lethal concentration 50; limonene; methyl chavicol; seed oils; seeds; toxicity; Iran
Abstract:
... In this study, biological properties of the essential oil isolated from seeds of Foeniculum vulgare (F. vulgare) were evaluated. GC-MS analysis revealed Trans-Anethole (80.63%), L-Fenchone (11.57%), Estragole (3.67%) and Limonene (2.68%) were the major compounds of the essential oil. Antibacterial activity of the essential oil against nine Gram-positive and Gram-negative strains was studied using ...
DOI:
10.1080/14786419.2017.1423310

32. Analytical methods to access the chemical composition of an Euphorbia tirucalli anticancer latex from traditional Brazilian medicine

Author:
Larissa Silva de Souza; Letícia C. Puziol; Cristina Luz Tosta; Milena L.F. Bittencourt; Juliana Santa Ardisson; Rodrigo Rezende Kitagawa; Paulo Roberto Filgueiras; Ricardo Machado Kuster
Source:
Journal of ethnopharmacology 2019 v.237 pp. 255-265
ISSN:
0378-8741
Subject:
Euphorbia tirucalli; adenocarcinoma; antineoplastic activity; atmospheric pressure; chemical composition; chemical constituents of plants; commercialization; cytotoxicity; diterpenoids; esters; gas chromatography-mass spectrometry; hexane; immunomodulators; inhibitory concentration 50; interleukin-6; ionization; latex; linoleic acid; macrophages; methanol; methylene chloride; monitoring; myristic acid; neoplasm cells; nitric oxide; nuclear magnetic resonance spectroscopy; oleic acid; palmitic acid; stearic acid; steroids; tandem mass spectrometry; traditional medicine; triterpenoids; tumor necrosis factor-alpha
Abstract:
... Euphorbia tirucalli L. is widely used by Brazilian folk medicine, mainly for its anticancer activity. However, its commercialization was banned by The Brazilian National Sanitary Surveillance Agency (ANVISA) due to the presence of some compounds considered toxic, such as the diterpene esters.Aim of the study: Chemical and biological analyses were performed with the Brazilian Euphorbia tirucalli la ...
DOI:
10.1016/j.jep.2019.03.041

33. Anchusa azurea Mill. (Boraginaceae) aerial parts methanol extract interfering with cytoskeleton organization induces programmed cancer cells death

Author:
Jessica CeramellaThese authors have contributed equally to the manuscript.; Monica Rosa Loizzo; Domenico Iacopetta; Marco Bonesi; Vincenzo Sicari; Teresa Maria Pellicanò; Carmela Saturnino; Aurélie Malzert-Fréon; Rosa TundisJoint senior authors.; Maria Stefania Sinicropi
Source:
Food & function 2019 v.10 no.7 pp. 4280-4290
ISSN:
2042-650X
Subject:
2,2-diphenyl-1-picrylhydrazyl; Anchusa azurea; aerial parts; antineoplastic activity; antioxidant activity; beta-carotene; bleaching; caffeic acid; caspase-3; catechin; cell death; cell lines; chemical composition; chlorogenic acid; cytoskeleton; death; high performance liquid chromatography; inhibitory concentration 50; menadione; methanol; mice; neoplasm cells; neoplasms; oxidative stress; toxicity
Abstract:
... The present study aimed to determine the chemical composition, antioxidant effects and antitumor properties of a methanol extract of Anchusa azurea Mill. (Boraginaceae) aerial parts against four tumour cell lines (MCF-7, MDA-MB-231, RKO, and R₂C). The antioxidant effects were assessed by using β-carotene bleaching, 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picryl ...
DOI:
10.1039/c9fo00582j

34. Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin

Author:
Luan He; Yong Zhang; Naixin Kang; Yaner Wang; Ziyu Zhang; Zhengxia Zha; Shilin Yang; Qiongming Xu; Yanli Liu
Source:
Phytomedicine 2019 v.56 pp. 136-146
ISSN:
0944-7113
Subject:
Anemone chinensis; Western blotting; adverse effects; anti-inflammatory activity; antineoplastic activity; antioxidant activity; apoptosis; blood; body weight; catalase; cell viability; cisplatin; creatinine; drug therapy; flow cytometry; glutathione; histopathology; in vivo studies; kidneys; mice; models; neoplasms; nephrotoxicity; protective effect; reactive oxygen species; renal failure; saponins; superoxide dismutase; urea nitrogen
Abstract:
... Cisplatin is a highly effective chemotherapeutic agent commonly used in the treatment of a wide variety of malignancies. However, its clinical usage is severely limited by its serious side effects, especially nephrotoxicity. Anemoside B4, is a major saponins, rich in root of Pulsatilla chinensis (Bunge), has anti-inflammation in vitro. However, the antioxidant or anti-inflammatory effects of anemo ...
DOI:
10.1016/j.phymed.2018.10.035

35. Angelica sinensis polysaccharide nanoparticles as a targeted drug delivery system for enhanced therapy of liver cancer

Author:
Yu Zhang; Zheng Cui; Hao Mei; Jingya Xu; Tao Zhou; Fang Cheng; Kaiping Wang
Source:
Carbohydrate polymers 2019 v.219 pp. 143-154
ISSN:
0144-8617
Subject:
Angelica sinensis; antineoplastic activity; biocompatibility; deoxycholic acid; dextran; doxorubicin; drug carriers; endocytosis; hydrophobicity; image analysis; liver neoplasms; nanoparticles; pH; particle size; solubility
Abstract:
... In recent years, the utilization of polysaccharides as targeted drug carriers has attracted considerable attention. Herein, Angelica sinensis polysaccharide (ASP), a plant polysaccharide with good biocompatibility, excellent aqueous solubility and intrinsic liver-targeted capability, was modified with hydrophobic group (deoxycholic acid) to fabricate amphiphilic conjugate (ASP-DOCA). Self-assemble ...
DOI:
10.1016/j.carbpol.2019.04.041

36. Anion Transporters Based on Noncovalent Balance including Anion−π, Hydrogen, and Halogen Bonding

Author:
Wen-Long Huang; Xu-Dong Wang; Sen Li; Rui Zhang; Yu-Fei Ao; Jun Tang; Qi-Qiang Wang; De-Xian Wang
Source:
Journal of organic chemistry 2019 v.84 no.14 pp. 8859-8869
ISSN:
1520-6904
Subject:
antineoplastic activity; aromatic hydrocarbons; bromides; cell viability; chemical reactions; chemical structure; density functional theory; fluorescence; gallic acid; halogens; hydrogen; inhibitory concentration 50; median effective concentration; nuclear magnetic resonance spectroscopy; organic chemistry; potassium chloride; transporters; triazines
Abstract:
... Anion transmembrane transport mediated by novel noncovalent interactions is of central interest in supramolecular chemistry. In this work, a series of oxacalix[2]arene[2]triazine-derived transporters 1 and 2 bearing anion−π-, hydrogen-, and halogen-bonding sites in rational proximity were designed and synthesized by a one-pot strategy starting from gallic acid ester derivatives and mono- or di-hal ...
DOI:
10.1021/acs.joc.9b00561

37. Antarctic Krill (Euphausia superba) Oil: A Comprehensive Review of Chemical Composition, Extraction Technologies, Health Benefits, and Current Applications

Author:
Dan Xie; Mengyue Gong; Wei Wei; Jun Jin; Xiaosan Wang; Xingguo Wang; Qingzhe Jin
Source:
Comprehensive reviews in food science and food safety 2019 v.18 no.2 pp. 514-534
ISSN:
1541-4337
Subject:
Euphausia superba; anti-inflammatory activity; antineoplastic activity; astaxanthin; cardiovascular diseases; dietary supplements; docosahexaenoic acid; eicosapentaenoic acid; flavonoids; ingredients; krill; minerals; neuroprotective effect; novel foods; oils; phospholipids; solvents; sterols; tocopherols; vitamin A; women's health
Abstract:
... Antarctic krill (Euphausia superba) oil has been receiving increasing attention due to its nutritional and functional potentials. However, its application as a novel food ingredient has not yet been fully explored. This review summarizes the chemical composition, extraction technologies, potential health benefits, and current applications of krill oil, with the aim of providing suggestions for its ...
DOI:
10.1111/1541-4337.12427

38. Anthocyanins/anthocyanidins and colorectal cancer: What is behind the scenes?

Author:
Luís Fernando de Sousa Moraes; Xiaofei Sun; Maria do Carmo Gouveia Peluzio; Mei-Jun Zhu
Source:
Critical reviews in food science and nutrition 2019 v.59 no.1 pp. 59-71
ISSN:
1549-7852
Subject:
AMP-activated protein kinase; anthocyanidins; anthocyanins; anticarcinogenic activity; antineoplastic activity; antioxidants; apoptosis; carcinogenesis; cell proliferation; chemoprevention; colorectal neoplasms; death; epithelial cells; intestines; mammals; metalloproteinases; metastasis; rapamycin; transcription factor NF-kappa B
Abstract:
... Colorectal cancer (CRC) is one of the most common cause of cancer death. Phytochemicals, especially anthocyanins/anthocyanidins (A/A), have gathered attention of the scientific community owing to their anti-inflammatory, antioxidant, and cancer-inhibitory properties. In this review, we discussed the possible mechanisms whereby A/A exhibit intestinal anticarcinogenic characteristics. Anthocyanins/a ...
DOI:
10.1080/10408398.2017.1357533

39. Anti-Neuroinflammatory Effects of Vanillin Through the Regulation of Inflammatory Factors and NF-κB Signaling in LPS-Stimulated Microglia

Author:
Mi Eun Kim; Ju Yong Na; Yong-Duk Park; Jun Sik Lee
Source:
Applied biochemistry and biotechnology 2019 v.187 no.3 pp. 884-893
ISSN:
0273-2289
Subject:
Alzheimer disease; Parkinson disease; antineoplastic activity; central nervous system; gene expression; homeostasis; immune response; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; macrophages; messenger RNA; mitogen-activated protein kinase; necrosis; neoplasms; neuroglia; nitric oxide; phosphorylation; prostaglandin synthase; protein content; therapeutics; transcription factor NF-kappa B; tumor necrosis factor-alpha; vanilla beans; vanillin
Abstract:
... Microglia, resident macrophages of the central nervous system (CNS), is responsible for immune responses and homeostasis of the CNS. Microglia plays a complex role in neuroinflammation, which has been implicated in neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Therefore, therapeutic agents that suppress the microglia-mediated inflammatory response could potentiall ...
DOI:
10.1007/s12010-018-2857-5

40. Anti-biofilm properties and immunological response of an immune molecule lectin isolated from shrimp Metapenaeus monoceros

Author:
Elumalai Preetham; Abdul Salam Rubeena; Baskaralingam Vaseeharan; Mukesh Kumar Chaurasia; Jesu Arockiaraj; Rolf Erik Olsen
Source:
Fish & shellfish immunology 2019 v.94 pp. 896-906
ISSN:
1050-4648
Subject:
Aeromonas hydrophila; Enterococcus faecalis; Metapenaeus monoceros; Saccharomyces cerevisiae; Staphylococcus aureus; Vibrio parahaemolyticus; affinity chromatography; agarose; antibacterial properties; antineoplastic activity; bacteria; binding capacity; carbohydrate binding; confocal laser scanning microscopy; disease control; encapsulation; enzyme activity; erythrocytes; hemagglutination; hemolymph; humans; lectins; light microscopy; mannose; molecular weight; monophenol monooxygenase; pH; polyacrylamide gel electrophoresis; shrimp; temperature; therapeutics; toxicity testing; yeasts
Abstract:
... The study is carried out to understand the antimicrobial and immunological response of a potential immune molecule lectin, MmLec isolated from haemolymph of Speckled shrimp, Metapenaeus monoceros. MmLec was purified using mannose coupled Sepharose CL-4B affinity chromatography, which was further subjected on SDS-PAGE to ascertain the distribution of their molecular weight. Sugar binding specificit ...
DOI:
10.1016/j.fsi.2019.09.032

41. Anti-cancer activities of S-allylmercaptocysteine from aged garlic

Author:
Yi LV; Kwok-Fai SO; Nai-Kei WONG; Jia XIAO
Source:
Chinese journal of natural medicines 2019 v.17 no.1 pp. 43-49
ISSN:
1875-5364
Subject:
Oriental traditional medicine; antineoplastic activity; apoptosis; dietary supplements; disease control; garlic; models; neoplasms; organic sulfur compounds
Abstract:
... While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract (AGE) exhibits stronger anti-cancer act ...
DOI:
10.1016/S1875-5364(19)30008-1

42. Anti-cancer activities of cytokinin ribosides

Author:
Jiří Voller; Tibor Béres; Marek Zatloukal; Petr Džubák; Marián Hajdúch; Karel Doležal; Thomas Schmülling; Strnad Miroslav
Source:
Phytochemistry reviews 2019 v.18 no.4 pp. 1101-1113
ISSN:
1568-7767
Subject:
antineoplastic activity; antineoplastic agents; apoptosis; cell lines; cytokinins; genes; growth and development; immune response; in vivo studies; mutants; neoplasms; patients; plant development; plant growth; plant hormones; stem cells
Abstract:
... Cytokinins are plant hormones and play essential roles in regulating plant growth and development. They also have diverse pharmacological effects in animals and humans. Whereas cytokinin bases have been studied mainly for their cytoprotective activities, cytokinin ribosides have been explored as anti-cancer agents. Cytokinin ribosides inhibit growth or cause apoptosis in various cell lines derived ...
DOI:
10.1007/s11101-019-09620-4

43. Anti-cancer activity of grape seed semi-polar extracts in human mesothelioma cell lines

Author:
Francesco DI Meo; Riccardo Aversano; Gianfranco Diretto; Olivia Costantina Demurtas; Clizia Villano; Salvatore Cozzolino; Stefania Filosa; Domenico Carputo; Stefania Crispi
Source:
Journal of functional foods 2019 pp. -
ISSN:
1756-4646
Subject:
antineoplastic activity; apoptosis; bioactive compounds; drug therapy; gene expression; grape seeds; grapes; human cell lines; mesothelioma; new drugs; proanthocyanidins; prognosis; seed extracts
Abstract:
... Malignant mesothelioma is a tumor that affects pleural surface and has very poor prognosis. The standard therapeutic modalities for this cancer have yielded unsatisfactory outcomes, therefore the development of alternative and effective therapies is currently an urgent requirement.Grapevine is a plant rich of bioactive compounds, known for its therapeutic effects. Here, we describe the anti-cancer ...
DOI:
10.1016/j.jff.2019.103515

44. Anti-cancer effect of Indanone-based thiazolyl hydrazone derivative on colon cancer cell lines

Author:
Silpa Narayanan; Pranav Gupta; Urooj Nazim; Mohsin Ali; Nishant Karadkhelkar; Mansoor Ahmad; Zhe-Sheng Chen
Source:
international journal of biochemistry & cell biology 2019 v.110 pp. 21-28
ISSN:
1357-2725
Subject:
DNA topoisomerase; antineoplastic activity; antineoplastic agents; apoptosis; biphenyl; cell lines; colorectal neoplasms; hydrazine; hydrazones; indans; inhibitory concentration 50; mitosis; neoplasm cells; patients; polymerization; toxicity; tubulin; United States
Abstract:
... Colorectal cancer is the third leading cause of cancer related deaths in the United States. Currently, Irinotecan, a topoisomerase I inhibitor, is an approved anti-cancer drug for the treatment of patients with advanced or recurrent colorectal cancer. Considering low response rate and events of high toxicity caused by irinotecan, we evaluated a series of thirteen thiazolyl hydrazone derivatives of ...
DOI:
10.1016/j.biocel.2019.02.004

45. Anti-cancer effect of marchantin C via inducing lung cancer cellular senescence associated with less secretory phenotype

Author:
Xiu-Lei Zhang; Xiao-Tian Ji; Bin Sun; Li-Lin Qian; Xue-Lei Hu; Hong-Xiang Lou; Hui-Qing Yuan
Source:
Biochimica et biophysica acta 2019 v.1863 no.10 pp. 1443-1457
ISSN:
0304-4165
Subject:
DNA damage; adverse effects; allografting; antineoplastic activity; cell senescence; cytotoxicity; doxorubicin; drug therapy; fluorescent antibody technique; immunoblotting; lung neoplasms; mice; models; neoplasm cells; phenotype; small interfering RNA; staining; toxicity testing
Abstract:
... Lung cancer is the leading cause of global cancer deaths. Current chemotherapeutic agents for lung cancer treatment are generally accompanied with severe side effects. Here, we report that marchantin C (Mar-C), a potential natural compound with little chemotherapeutic toxicity, exerts a well anti-tumor effect against lung cancer via inducing cellular senescence.The antitumor activity of Mar-C was ...
DOI:
10.1016/j.bbagen.2019.05.006

46. Anti-cancer effect of toosendanin and its underlying mechanisms

Author:
Sha Zhang; Liang Cao; Zong-Ren Wang; Zhe Li; Jing Ma
Source:
Journal of Asian natural products research 2019 v.21 no.3 pp. 270-283
ISSN:
1477-2213
Subject:
Melia azedarach; antineoplastic activity; cell viability; estrogen receptors; glioblastoma; insecticides; medicinal plants; models; neoplasm cells; triterpenoids
Abstract:
... Toosendanin (TSN) is a triterpenoid purified from the medicinal herb Melia toosendan Sieb. et Zucc and has been used as an insecticide for decades. Recent studies have attracted increasing interest of TSN due to its novel anti-cancer effect in diverse cancer models. The broad spectrum anti-cancer activity suggests that TSN inhibits multiple pathways/targets that are critical for cancer cell surviv ...
DOI:
10.1080/10286020.2018.1451516

47. Anti-cancer effects of ethanol extract of Reynoutria japonica Houtt. radix in human hepatocellular carcinoma cells via inhibition of MAPK and PI3K/Akt signaling pathways

Author:
Ba Reum Kim; Jain Ha; Sewoong Lee; Jiyoung Park; Sayeon Cho
Source:
Journal of ethnopharmacology 2019 pp. -
ISSN:
0378-8741
Subject:
Reynoutria japonica; antineoplastic activity; cadherins; cell viability; cytotoxicity; dose response; enzyme activity; enzyme inhibition; ethanol; gelatinase A; hepatoma; human diseases; humans; metastasis; mitogen-activated protein kinase; neoplasm cells; non-specific serine/threonine protein kinase; phosphatidylinositol 3-kinase; phosphorylation; protein content; signal transduction; therapeutics; tissue repair; traditional medicine; viability assays; vimentin; East Asia
Abstract:
... Reynoutria japonica Houtt. has been used as a traditional medicine of cancer in East Asia for thousands of years. However, the mechanism of the anti-cancer effect of R. japonica has not been investigated at the molecular level. The regulation of intracellular signaling pathways by the extract of R. japonica radix needs to be evaluated for a deeper understanding and application of the anti-cancer e ...
DOI:
10.1016/j.jep.2019.112179

48. Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions

Author:
Haroon Khan; Marcella Reale; Hammad Ullah; Antoni Sureda; Silvia Tejada; Ying Wang; Zhang-Jin Zhang; Jianbo Xiao
Source:
Biotechnology advances 2019 pp. -
ISSN:
0734-9750
Subject:
antineoplastic activity; cell lines; chemoprevention; dietary nutrient sources; mechanism of action; monitoring; neoplasm cells; neoplasms; polyphenols; signal transduction; tumor suppressor genes
Abstract:
... The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. The aim of this review is to ...
DOI:
10.1016/j.biotechadv.2019.04.007

49. Anti-inflammatory activity of the sesquiterpene lactone diacethylpiptocarphol in dextransulfate sodium-induced colitis in mice

Author:
R. Sabel; A.S. Fronza; L.Z.B. Carrenho; A. Maes; M.L. Barros; L.A.E. Pollo; M.W. Biavatti; K. D'Herde; P. Vandenabeele; M.R.O. Kreuger
Source:
Journal of ethnopharmacology 2019 pp. -
ISSN:
0378-8741
Subject:
Vernonia; anti-inflammatory activity; antineoplastic activity; body weight; colitis; interleukin-1; mechanism of action; mice; models; sesquiterpenoid lactones; traditional medicine; transcription factor NF-kappa B; transforming growth factor beta; tumor necrosis factor-alpha
Abstract:
... Sesquiterpene lactones are organic compounds derived mainly from plants that exhibit anti-inflammatory and antitumor activities being one of the key mechanism of action of NF-kB pathway and synthesis of cytokines such as IL-1 and TNF- α.The overall objective of the present study was to evaluate the anti-inflammatory action of a sesquiterpene lactone diacethylpiptocarphol (DPC) from Vernonia scorpi ...
DOI:
10.1016/j.jep.2019.112186

50. Anti-leukemic effects of simvastatin on NRASG12D mutant acute myeloid leukemia cells

Author:
Jiryeon Jang; Jeeyun Lee; Jun Ho Jang; Chul Won Jung; Silvia Park
Source:
Molecular biology reports 2019 v.46 no.6 pp. 5859-5866
ISSN:
0301-4851
Subject:
Western blotting; antineoplastic activity; apoptosis; cell cycle checkpoints; cell lines; cell proliferation; cell viability; cholesterol; cytotoxicity; flow cytometry; humans; molecular biology; mutants; myeloid leukemia; simvastatin; therapeutics
Abstract:
... The statins are a group of therapeutic drugs widely used for lowering plasma cholesterol level, while it has also been reported to induce cell death in human acute myeloid leukemia (AML) cells. To determine antitumor activity triggered by simvastatin, four AML cell lines—U937, KG1, THP1 (NRASᴳ¹²ᴰ mutant) and HL60 (NRASQ⁶¹ᴸ mutant)—were cultured with simvastatin and cell viability was assessed usin ...
DOI:
10.1007/s11033-019-05019-8