Publication Year: 2019 / Subject: antineoplastic activity

1. 16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity in vivo and in vitro

Author:: Yiren Yang; Liping Long; Xinxin Zhang; Kairu Song; Da Wang; Xin Xiong; Huiyuan Gao; Luping Sha
Source:: RSC advances 2019 v.9 no.54 pp. 31758-31772
ISSN:: 2046-2069
Subject:: antineoplastic activity; apoptosis; breasts; doxorubicin; glycosides; hemolysis; human cell lines; humans; hydrolysates; lungs; metastasis; mice; neoplasm cells; neoplasm progression; toxicity; triterpenoids; uterine cervical neoplasms
Abstract:: ... Barrigenol-like triterpenoids (BATs) showed promising anti-tumor, anti-inflammatory and anti-Alzheimer's activities, while, the inhibitory strength was usually affected by their states with aglycones or glycosides. In order to find more BATs as new anti-tumor agents with much more efficiency, the chemical and pharmaceutical studies were carried out on the acid hydrolysate product (AHP) of Semen Ae ...
DOI:: 10.1039/c9ra06015d
: https://doi.org/10.1039/c9ra06015d

2. 1‐O‐alkylglycerols from the hepatopancreas of the crab Paralithodes camtschaticus, liver of the squid Berryteuthis magister, and liver of the skate Bathyraja parmifera, and their anticancer activity on human melanoma cells

Author:: Nikolay A. Latyshev; Svetlana P. Ermakova; Ekaterina V. Ermolenko; Andrey B. Imbs; Sergey P. Kasyanov; Ruslan M. Sultanov
Source:: Journal of food biochemistry 2019 v.43 no.5 pp. e12828
ISSN:: 0145-8884
Subject:: Bathyraja; Paralithodes camtschatica; antineoplastic activity; aquatic organisms; crabs; cytotoxicity; hepatopancreas; human cell lines; inhibitory concentration 50; lipids; liver; melanoma; squid; therapeutics
Abstract:: ... 1‐O‐alkylglycerols (AKG) are a class of natural ether lipids derived from 1‐O‐alkyl‐2,3‐diacyl‐sn‐glycerols by deacylation. In this study, 1‐O‐alkylglycerol (AKG) composition was investigated in the hepatopancreas lipids of the crab Paralithodes camtschaticus and the liver lipids of the squid Berryteuthis magister and the skate Bathyraja parmifera. One of the principal AKG in marine organisms was ...
DOI:: 10.1111/jfbc.12828
: https://doi.org/10.1111/jfbc.12828

3. 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells

Author:: Wuguo Li; Qing Zhang; Kaotan Chen; Zhenhua Sima; Jingli Liu; Qiang Yu; Jiawei Liu
Source:: BMC complementary and alternative medicine 2019 v.19 no.1 pp. 38
ISSN:: 1472-6882
Subject:: Reynoutria japonica; Western blotting; alternative medicine; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle; cell growth; cell viability; chemical structure; dose response; drug resistance; ethyl acetate; flow cytometry; gels; hepatoma; high performance liquid chromatography; humans; inhibitory concentration 50; juglone; luciferase; metastasis; nuclear magnetic resonance spectroscopy; oncogenes; phosphorylation; physicochemical properties; relapse; reporter genes; roots; signal transduction; spectral analysis; stem cells; transactivators; transcription (genetics); tyrosine
Abstract:: ... BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is an oncogene constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells (CSCs). Constitutively activated STAT3 plays a pivotal role in holding cancer stemness of HCC CSCs, which are essential for hepatoma initiation, relapse, metastasis and drug resistance. Therefore, STAT3 has been validated a ...
DOI:: 10.1186/s12906-019-2440-9
PubMed:: 30709346
PubMed Central:: PMC6359800
: https://doi.org/10.1186/s12906-019-2440-9

4. 3‐Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau

Author:: Young H. Ko; Katarzyna Niedźwiecka; Margarida Casal; Peter L. Pedersen; Stanisław Ułaszewski
Source:: Yeast 2019 v.36 no.4 pp. 211-221
ISSN:: 0749-503X
Subject:: Cryptococcus neoformans; adenosine triphosphate; adverse effects; algae; animal models; antimicrobial properties; antineoplastic activity; apoptosis; bromination; cancer therapy; cell movement; fungi; glucose; glycolysis; hexokinase; lactic acid; mitochondria; neoplasm cells; neoplasms; oxygen; patients; pumps; pyruvic acid; transporters
Abstract:: ... 3‐Bromopyruvate (3BP) is a small, highly reactive molecule formed by bromination of pyruvate. In the year 2000, the antitumor properties of 3BP were discovered. Studies using animal models proved its high efficacy for anticancer therapy with no apparent side effects. This was also found to be the case in a limited number of cancer patients treated with 3BP. Due to the “Warburg effect,” most tumor ...
DOI:: 10.1002/yea.3367
: https://doi.org/10.1002/yea.3367

5. 4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer

Author:: Zhicong Zhao; Dongsheng Shang; Lipeng Qiu; Chang Guo; Yanyan Li; Hanqing Liu; Guoyue Yuan; Zhigang Tu
Source:: Life sciences 2019 v.238 pp. 116973
ISSN:: 0024-3205
Subject:: DNA damage; antineoplastic activity; antineoplastic agents; cell senescence; drug therapy; enzymes; fluorescent antibody technique; heterocyclic nitrogen compounds; in vitro studies; in vivo studies; mice; screening; signal transduction; staining; stomach neoplasms; survival rate
Abstract:: ... Gastric cancer (GC) is a common cancer with a relatively low survival rate. Cellular senescence, a potent anti-cancer mechanism, is naturally occurred, and can be induced by chemotherapeutic agents. We sought to explore new compounds against GC cells by inducing cellular senescence.Primary screening of a library of N-heterocyclic compounds identified some with potent inhibitory effects on GC cells ...
DOI:: 10.1016/j.lfs.2019.116973
: https://doi.org/10.1016/j.lfs.2019.116973

6. 7-O-geranylquercetin contributes to reverse P-gp-mediated adriamycin resistance in breast cancer

Author:: Enxia Zhang; Jiasi Liu; Lei Shi; Xin Guo; Ze Liang; Jiaxin Zuo; Hong Xu; Huaxin Wang; Xiaohong Shu; Shanshan Huang; Shubiao Zhang; Xiaohui Kang; Yuhong Zhen
Source:: Life sciences 2019 v.238 pp. 116938
ISSN:: 0024-3205
Subject:: P-glycoproteins; Western blotting; antineoplastic activity; breast neoplasms; caudal vein; computer simulation; doxorubicin; drug resistance; drug therapy; flow cytometry; fluorescence microscopes; fluorescence microscopy; gene expression regulation; genes; mice; molecular models; quantitative polymerase chain reaction; quercetin; rhodamines; tissues; toxicity testing; viability
Abstract:: ... To investigate the effect of 7-O-geranylquercetin (GQ), a derivative of quercetin (Q), on reversing drug resistance in breast cancer MCF-7/ADR cells and reveal the mechanisms related to P-glycoprotein (P-gp).Cell viability was determined by MTT assay. Accumulation of adriamycin (ADR) in cells was determined by confocal fluorescence microscope and microplate reader while that of rhodamine (Rh) was ...
DOI:: 10.1016/j.lfs.2019.116938
: https://doi.org/10.1016/j.lfs.2019.116938

7. Berberis Plants—Drifting from Farm to Food Applications, Phytotherapy, and Phytopharmacology

Author:: Bahare Salehi; Zeliha Selamoglu; Bilge Sener; Mehtap Kilic; Arun Kumar Jugran; Nunziatina de Tommasi; Chiara Sinisgalli; Luigi Milella; Jovana Rajkovic; Maria Flaviana B. Morais-Braga; Camila F. Bezerra; Janaína E. Rocha; Henrique D.M. Coutinho; Adedayo Oluwaseun Ademiluyi; Zabta Khan Shinwari; Sohail Ahmad Jan; Ebru Erol; Zulfiqar Ali; Elise Adrian Ostrander; Javad Sharifi-Rad; María de la Luz Cádiz-Gurrea; Yasaman Taheri; Miquel Martorell; Antonio Segura-Carretero; William C. Cho
Source:: Foods 2019 v.8 no.10 pp. -
ISSN:: 2304-8158
Subject:: Berberis; alkaloids; antimicrobial properties; antineoplastic activity; antioxidants; bioactive compounds; chemical constituents of plants; diabetes; essential oils; farms; flavorings; food industry; food preservation; fruit juices; fruits; gas chromatography; leaves; limonene; neoplasms; ocimene; oleanolic acid; p-cymene; pharmaceutical industry; phytotherapy; tannins; toxicity; Europe; Iran; Pakistan; United States
Abstract:: ... The genus Berberis includes about 500 different species and commonly grown in Europe, the United States, South Asia, and some northern areas of Iran and Pakistan. Leaves and fruits can be prepared as food flavorings, juices, and teas. Phytochemical analysis of these species has reported alkaloids, tannins, phenolic compounds and oleanolic acid, among others. Moreover, p-cymene, limonene and ocimen ...
DOI:: 10.3390/foods8100522
PubMed:: 31652576
PubMed Central:: PMC6836240
: https://doi.org/10.3390/foods8100522

8. Lactobacillus acidophilus-Fermented Germinated Brown Rice Suppresses Preneoplastic Lesions of the Colon in Rats

Author:: Sing-Chung Li; Han-Pei Lin; Jung-Su Chang; Chun-Kuang Shih
Source:: Nutrients 2019 v.11 no.11 pp. -
ISSN:: 2072-6643
Subject:: 1,2-dimethylhydrazine; B-cell lymphoma; Lactobacillus acidophilus; antineoplastic activity; apoptosis; blood serum; brown rice; carcinogenesis; caspase-3; chemoprevention; colon; colorectal neoplasms; dextran sulfate; dietary supplements; inflammation; interleukin-1beta; interleukin-6; probiotics; protective effect; rats; tumor necrosis factor-alpha; whole grain foods
Abstract:: ... Colorectal cancer (CRC) is a cancer associated with chronic inflammation. Whole grains and probiotics play a protective role against CRC. Fermented grains are receiving increased attention due to their anti-inflammatory and anti-cancer activities. Our previous study found that a combination of germinated brown rice (GBR) with probiotics suppressed colorectal carcinogenesis in rats. However, the ca ...
DOI:: 10.3390/nu11112718
PubMed:: 31717536
PubMed Central:: PMC6893647
: https://doi.org/10.3390/nu11112718

9. AKT1-targeted proapoptotic activity of compound K in human breast cancer cells

Author:: Eunju Choi; Eunji Kim; Ji Hye Kim; Keejung Yoon; Sunggyu Kim; Jongsung Lee; Jae Youl Cho
Source:: Journal of Ginseng Research 2019 v.43 no.4 pp. 692-698
ISSN:: 1226-8453
Subject:: Panax; antineoplastic activity; apoptosis; breast neoplasms; cancer therapy; caspase-7; caspase-8; caspase-9; cell viability; death; disease severity; flow cytometry; humans; immunoblotting; intestines; metabolites; neoplasm cells; propidium; research; saponins
Abstract:: ... Breast cancer is a severe disease and the second leading cause of cancer death in women worldwide. To surmount this, various diagnosis and treatment options for breast cancer have been developed. One of the most effective strategies for cancer treatment is to induce apoptosis using naturally occurring compounds. Compound K (CK) is a ginseng saponin metabolite generated by human intestinal bacteria ...
DOI:: 10.1016/j.jgr.2019.07.001
: https://doi.org/10.1016/j.jgr.2019.07.001

10. Acacetin‐induced cell apoptosis in head and neck squamous cell carcinoma cells: Evidence for the role of muscarinic M3 receptor

Author:: Fenglin Sun; Duo Li; Cong Wang; Caixia Peng; Hong Zheng; Xiaofeng Wang
Source:: Phytotherapy research 2019 v.33 no.5 pp. 1551-1561
ISSN:: 0951-418X
Subject:: antineoplastic activity; apoptosis; calcium; calcium signaling; caspase-3; caspase-9; cell lines; cell viability; cytochrome c; electron microscopy; flavones; flow cytometry; mitochondria; neoplasm cells; small interfering RNA; squamous cell carcinoma
Abstract:: ... Aacacetin, a plant flavone has shown antitumor efficacy recently. However, its associated mechanisms are poorly known. We hypothesized that the muscarinic M3 receptor (M₃R), which is highly expressed in some cancer tissue, is related to the antitumor effect of acacetin in head and neck squamous cell carcinoma (HNSCC) cells. Our results showed that 12.5‐ to 200‐μM acacetin inhibited cell viability ...
DOI:: 10.1002/ptr.6343
: https://doi.org/10.1002/ptr.6343

11. Acid and light stimuli-responsive mesoporous silica nanoparticles for controlled release

Author:: Mingdong Wang; Ting Wang; Dong Wang; Wei Jiang; Jiajun Fu
Source:: Journal of materials science 2019 v.54 no.8 pp. 6199-6211
ISSN:: 0022-2461
Subject:: alpha-cyclodextrin; antineoplastic activity; breast neoplasms; doxorubicin; encapsulation; humans; hydrazones; irradiation; mechanization; nanoparticles; neoplasm cells; pH; porous media; silica; ultraviolet radiation
Abstract:: ... We constructed a novel stimuli-responsive system, MSNPs 1, based on mechanized silica nanoparticles, in which mesoporous silica nanoparticles (MSNs) acted as nanocontainers to load cargo, and supramolecular switches consisting of hydrazone bond, azobenzene and α-cyclodextrin (α-CD) realized the controlled release of cargo molecules from MSNPs 1. In neutral solution and without UV light irradiation ...
DOI:: 10.1007/s10853-019-03325-x
: https://doi.org/10.1007/s10853-019-03325-x

12. Actinidia chinensis Planch root extract attenuates proliferation and metastasis of hepatocellular carcinoma by inhibiting epithelial-mesenchymal transition

Author:: Tingting Fang; Yuan Fang; Xiaojing Xu; Mingyan He; Zhiying Zhao; Peixin Huang; Feifei Yuan; Mengzhou Guo; Biwei Yang; Jinglin Xia
Source:: Journal of ethnopharmacology 2019 v.231 pp. 474-485
ISSN:: 0378-8741
Subject:: Actinidia chinensis; Oriental traditional medicine; animal models; antineoplastic activity; apoptosis; cell proliferation; cell viability; cytotoxicity; diuresis; gene expression; gene expression regulation; genes; hemostasis; hepatoma; herbs; messenger RNA; metastasis; patients; prognosis; quantitative polymerase chain reaction
Abstract:: ... Numerous studies have demonstrated the potent anticancer activity of various Chinese herbs. Actinidia chinensis Planch root (acRoots), a traditional Chinese medicine, functions as an antitumor and detoxifying agent and plays a role in diuresis and hemostasis. Treatment with acRoots confers strong inhibition of tumor growth in various forms of cancer. Here, we evaluated the anticancer activity and ...
DOI:: 10.1016/j.jep.2018.11.014
: https://doi.org/10.1016/j.jep.2018.11.014

13. Activated TNF-α/RIPK3 signaling is involved in prolonged high fat diet-stimulated hepatic inflammation and lipid accumulation: inhibition by dietary fisetin intervention

Author:: Minxuan XuThese authors contributed equally to this work.; Chenxu Ge; Yuting Qin; Tingting Gu; Jinxiao Lv; Sujun Wang; Yongjie Ma; Deshuai Lou; Qiang Li; Linfeng Hu; Xuyuan Nie; Mingxing Wang; Ping Huang; Jun Tan
Source:: Food & function 2019 v.10 no.3 pp. 1302-1316
ISSN:: 2042-650X
Subject:: antineoplastic activity; blood serum; fatty liver; flavonoids; gene expression; gene expression regulation; high fat diet; inflammation; lipids; liver; liver function; metabolic diseases; metabolic syndrome; mice; neoplasms; polyphenols; protective effect; protein kinases; tumor necrosis factor-alpha
Abstract:: ... Increasing evidence indicates that high-fat diet (HFD) is a predisposing factor for metabolic syndrome-associated systemic inflammation and nonalcoholic fatty liver disease (NAFLD). Tumor necrosis factor-α/receptor-interacting protein kinase 3 (TNF-α/RIPK3) axis has recently become regarded as an important regulator and contributor in many inflammation-related diseases. Fisetin (Fn) is a bioactive ...
DOI:: 10.1039/c8fo01615a
: https://doi.org/10.1039/c8fo01615a

14. Ad5-EMC6 mediates antitumor activity in gastric cancer cells through the mitochondrial apoptosis pathway

Author:: Riyong Li; Xiaokun Wang; Xuan Zhang; Jiahong Yu; Jinqiu Feng; Ping Lv; Yaxin Lou; Yingyu Chen
Source:: Biochemical and biophysical research communications 2019 v.513 no.3 pp. 663-668
ISSN:: 0006-291X
Subject:: antineoplastic activity; apoptosis; carcinogenesis; cell growth; drug therapy; endoplasmic reticulum; etoposide; membrane potential; mice; mitochondria; mitochondrial membrane; models; neoplasm cells; stomach neoplasms; transmembrane proteins
Abstract:: ... Endoplasmic reticulum membrane protein complex subunit 6 (EMC6), also known as transmembrane protein 93 (transmembrane protein 93, TMEM93), is an autophagy-related protein. EMC6 overexpression inhibits cancer cell growth and induces apoptosis, but the interaction partners of EMC6 and its cellular responsibilities remain incompletely understood. In this study, we report that adenovirus-mediated ect ...
DOI:: 10.1016/j.bbrc.2019.04.023
: https://doi.org/10.1016/j.bbrc.2019.04.023

15. Advances in phytochemical delivery systems for improved anticancer activity

Author:: Ricardo Lagoa; João Silva; Joaquim Rui Rodrigues; Anupam Bishayee
Source:: Biotechnology advances 2019 pp. -
ISSN:: 0734-9750
Subject:: antineoplastic activity; berberine; bioavailability; chemical constituents of plants; colon; curcumin; drug delivery systems; flavonoids; nanoemulsions; nanoparticles; neoplasms; nose; pharmacokinetics; resveratrol
Abstract:: ... Natural compounds have significant anticancer pharmacological activities, but often suffer from low bioavailability and selectivity that limit therapeutic use. The present work critically analyzes the latest advances on drug delivery systems designed to enhance pharmacokinetics, targeting, cellular uptake and efficacy of anticancer phytoconstituents. Various phytochemicals, including flavonoids, r ...
DOI:: 10.1016/j.biotechadv.2019.04.004
: https://doi.org/10.1016/j.biotechadv.2019.04.004

16. AgBiS₂-TPP nanocomposite for mitochondrial targeting photodynamic therapy, photothermal therapy and bio-imaging under 808 nm NIR laser irradiation

Author:: Mingdi Sun; Dan Yang; Chen Wang; Huiting Bi; Yuan Zhou; Xiangxi Wang; Jiating Xu; Fei He; Shili Gai; Piaoping Yang
Source:: Biomaterials science 2019 v.7 no.11 pp. 4769-4781
ISSN:: 2047-4849
Subject:: antineoplastic activity; bioimaging; computed tomography; energy; irradiation; mitochondria; nanocomposites; nanoparticles; near infrared radiation; near-infrared spectroscopy; neoplasm cells; neoplasms; patients; photochemotherapy; photothermotherapy; population growth; precision medicine; reactive oxygen species; sulfides
Abstract:: ... 808 nm near-infrared (NIR) light-induced biological theranostics is gradually becoming a popular method for cancer treatment. Meanwhile, mild synthetic methods to prepare medicines and gentle treatment conditions for cancer patients are becoming increasingly important to oncotherapy. Herein, tiny AgBiS₂ nanodots were synthesized via a simple method, and for the first time, discovered to produce a ...
DOI:: 10.1039/c9bm01077g
: https://doi.org/10.1039/c9bm01077g

17. Ailanthone inhibits cell growth and migration of cisplatin resistant bladder cancer cells through down-regulation of Nrf2, YAP, and c-Myc expression.

Author:: Martina Daga; Stefania Pizzimenti; Chiara Dianzani; Marie Angele Cucci; Roberta Cavalli; Margherita Grattarola; Benedetta Ferrara; Valentina Scariot; Francesco Trotta; Giuseppina Barrera
Source:: Phytomedicine 2019 v.56 pp. 156-164
ISSN:: 0944-7113
Subject:: Ailanthus altissima; Western blotting; active ingredients; antibodies; antineoplastic activity; apoptosis; bladder; cell growth; cell lines; cell movement; cisplatin; cortex; essential genes; flow cytometry; gene expression; humans; interphase; neoplasm cells; protein synthesis; staining; therapeutics; tissue repair; toxicity; urinary bladder neoplasms
Abstract:: ... Ailanthone (Aila) is a natural active compound isolated from the Ailanthus altissima, which has been shown to possess an “in vitro” growth-inhibitory effect against several cancer cell lines. Advanced bladder cancer is a common disease characterized by a frequent onset of resistance to cisplatin-based therapy. The cisplatin (CDDP) resistance is accompanied by an increase in Nrf2 protein expression ...
DOI:: 10.1016/j.phymed.2018.10.034
: https://doi.org/10.1016/j.phymed.2018.10.034

18. An Alcohol-Soluble Polysaccharide from Atractylodes macrocephala Koidz Induces Apoptosis of Eca-109 cells

Author:: Ying-ying Feng; Hai-yu Ji; Xiao-dan Dong; An-jun Liu
Source:: Carbohydrate polymers 2019 pp. -
ISSN:: 0144-8617
Subject:: Atractylodes macrocephala; Fourier transform infrared spectroscopy; Western blotting; antineoplastic activity; apoptosis; arabinose; dyes; esophageal neoplasms; gas chromatography; gel chromatography; glucose; glycosidic linkages; interphase; mitochondria; polysaccharides; rhodamines; staining; therapeutics
Abstract:: ... In this study, polysaccharides from Atractylodes macrocephala Koidz (APA) which were soluble in alcohol were prepared, purified, analyzed the structure and investigated the antitumor activity in vitro cell experiment. Results of high-performance gel permeation chromatography (HPGPC), fourier-transform infrared spectroscopy (FT-IR), and gas chromatography (GC) showed that APA was a 2.1KDa neutral h ...
DOI:: 10.1016/j.carbpol.2019.115136
: https://doi.org/10.1016/j.carbpol.2019.115136

19. Algae metabolites: from in vitro growth inhibitory effects to promising anticancer activity

Author:: Florence Lefranc; Aikaterini Koutsaviti; Efstathia Ioannou; Alexander Kornienko; Vassilios Roussis; Robert Kiss; David Newman
Source:: Natural product reports 2019 v.36 no.5 pp. 810-841
ISSN:: 1460-4752
Subject:: algae; antineoplastic activity; autotrophs; drug therapy; marine environment; metabolites; metastasis; models; neoplasm cells; neoplasms; signal transduction; transporters
Abstract:: ... Covering: 1957 to 2017 Algae constitute a heterogeneous group of eukaryotic photosynthetic organisms, mainly found in the marine environment. Algae produce numerous metabolites that help them cope with the harsh conditions of the marine environment. Because of their structural diversity and uniqueness, these molecules have recently gained a lot of interest for the identification of medicinally use ...
DOI:: 10.1039/c8np00057c
: https://doi.org/10.1039/c8np00057c

20. Alkaloids isolated from Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae: Anticancer activity of coccinine and montanine

Author:: M. Masi; S. Van slambrouck; S. Gunawardana; M.J. van Rensburg; P.C. James; J.G. Mochel; P.S. Heliso; A.S. Albalawi; A. Cimmino; W.A.L. van Otterlo; A. Kornienko; I.R. Green; A. Evidente
Source:: South African journal of botany 2019 v.126 pp. 277-281
ISSN:: 0254-6299
Subject:: Haemanthus; antineoplastic activity; bulbs; human cell lines; humans; lycorine; metabolites; neoplasm cells
Abstract:: ... Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae, was studied for the first time for its alkaloid content. From the acid extract of its bulbs, albomaculine, incartine, coccinine and montanine, belonging to the lycorine-, homolycorine- and isoquinoline-type alkaloids respectively, were isolated. Coccinine was the main metabolite (1.49 g/kg) and to the best of our knowledge H. hu ...
DOI:: 10.1016/j.sajb.2019.01.036
: https://doi.org/10.1016/j.sajb.2019.01.036

21. Ameliorative effects of aqueous extract of Forsythiae suspensa fruits on oxaliplatin-induced neurotoxicity in vitro and in vivo

Author:: Jin-Mu Yi; Sarah Shin; No Soo Kim; Ok-Sun Bang
Source:: BMC complementary and alternative medicine 2019 v.19 no.1 pp. 339
ISSN:: 1472-6882
Subject:: Forsythia suspensa; Oriental traditional medicine; adverse effects; alternative medicine; antibodies; antineoplastic activity; antineoplastic agents; colorectal neoplasms; cytotoxicity; dried fruit; drug therapy; fruits; ganglia; herbal medicines; human diseases; immunohistochemistry; liquid chromatography; males; models; neoplasm cells; nerve growth factor; neurites; neuroprotective effect; neurotoxicity; patients; peripheral nervous system diseases; quality of life; staining; viability assays
Abstract:: ... BACKGROUND: The dried fruits of Forsythia suspensa has generally been used to clear heat and detoxify in traditional Korean and Chinese medicine. Oxaliplatin is a first-line treatment chemotherapeutic agent for advanced colorectal cancer, but it induces peripheral neuropathy as an adverse side effect affecting the treatment regimen and the patient’s quality of life. The present study was conducted ...
DOI:: 10.1186/s12906-019-2761-8
PubMed:: 31783843
PubMed Central:: PMC6884752
: https://doi.org/10.1186/s12906-019-2761-8

22. Amino modified metal-organic frameworks as pH-responsive nanoplatforms for safe delivery of camptothecin

Author:: Alejandro Cabrera-García; Elisa Checa-Chavarria; Eva Rivero-Buceta; Victoria Moreno; Eduardo Fernández; Pablo Botella
Source:: Journal of colloid and interface science 2019 v.541 pp. 163-174
ISSN:: 0021-9797
Subject:: antineoplastic activity; biocompatibility; chemical bonding; coordination polymers; cytotoxicity; drug carriers; drugs; in vitro studies; iron; pH; porous media
Abstract:: ... MIL-100(Fe) and MIL-101(Fe) metal-organic frameworks (MOFs) are excellent vehicles for drug delivery systems (DDSs) due to their high biocompatibility and stability in physiological fluids, as well as their pore diameter in the mesoporous range. Although they are appropriate for the internal diffusion of 20-(S)-camptothecin (CPT), a strongly cytotoxic molecule with excellent antitumor activity, no ...
DOI:: 10.1016/j.jcis.2019.01.042
: https://doi.org/10.1016/j.jcis.2019.01.042

23. Amphidinol 22, a New Cytotoxic and Antifungal Amphidinol from the Dinoflagellate Amphidinium carterae

Author:: Kevin A. Martínez; Chiara Lauritano; Dana Druka; Giovanna Romano; Teresa Grohmann; Marcel Jaspars; Jesús Martín; Caridad Díaz; Bastien Cautain; Mercedes de la Cruz; Adrianna Ianora; Fernando Reyes
Source:: Marine drugs 2019 v.17 no.7 pp. -
ISSN:: 1660-3397
Subject:: Amphidinium; Aspergillus fumigatus; Escherichia coli; Gram-negative bacteria; Gram-positive bacteria; Klebsiella pneumoniae; Mycobacterium tuberculosis; adenocarcinoma; antifungal properties; antineoplastic activity; bioactive compounds; biodiversity; breast neoplasms; breasts; cell lines; cytotoxicity; fractionation; fungi; habitats; hepatoma; humans; lungs; mass spectrometry; melanoma; methicillin-resistant Staphylococcus aureus; neoplasm cells; nuclear magnetic resonance spectroscopy; pancreas; physicochemical properties; skin (animal)
Abstract:: ... Due to the unique biodiversity and the physical-chemical properties of their environment, marine microorganisms have evolved defense and signaling compounds that often have no equivalent in terrestrial habitats. The aim of this study was to screen extracts of the dinoflagellate Amphidinium carterae for possible bioactivities (i.e., anticancer, anti-inflammatory, anti-diabetes, antibacterial and an ...
DOI:: 10.3390/md17070385
PubMed:: 31252576
PubMed Central:: PMC6669446
: https://doi.org/10.3390/md17070385

24. Amphiphilic Gemini Iridium(III) Complex as a Mitochondria-Targeted Theranostic Agent for Tumor Imaging and Photodynamic Therapy

Author:: Sili Yi; Zhen Lu; Jin Zhang; Jun Wang; Zenghong Xie; Linxi Hou
Source:: ACS applied materials & interfaces 2019 v.11 no.17 pp. 15276-15289
ISSN:: 1944-8252
Subject:: antineoplastic activity; diagnostic techniques; emissions factor; human cell lines; image analysis; in vivo studies; iridium; ligands; mitochondria; neoplasm cells; neoplasms; photochemotherapy; photostability; phototoxicity; quaternary ammonium compounds; singlet oxygen; spectroscopy; water solubility
Abstract:: ... Clinical diagnostics and therapeutics of tumors are significantly benefitted by the development of multifunctional theranostic agents, which integrate tumor targeting, imaging, and therapeutics. However, the integration of imaging and therapy functionalities to a unimolecular framework remains a great challenge. Herein, a family of amphiphilic gemini iridium(III) complexes (GIC), Ir1–Ir6, are synt ...
DOI:: 10.1021/acsami.9b01205
: https://doi.org/10.1021/acsami.9b01205

25. Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from Foeniculum vulgare from Hamedan, Iran

Author:: Maryam Akhbari; Reza Kord; Saeedeh Jafari Nodooshan; Sepideh Hamedi
Source:: Natural product research 2019 v.33 no.11 pp. 1629-1632
ISSN:: 1478-6427
Subject:: Artemia; Escherichia coli; Foeniculum vulgare; Pseudomonas aeruginosa; Shigella dysenteriae; antibacterial properties; antineoplastic activity; antineoplastic agents; breast neoplasms; carcinoma; cell lines; death; essential oils; gas chromatography-mass spectrometry; humans; inhibitory concentration 50; lethal concentration 50; limonene; methyl chavicol; seed oils; seeds; toxicity; Iran
Abstract:: ... In this study, biological properties of the essential oil isolated from seeds of Foeniculum vulgare (F. vulgare) were evaluated. GC-MS analysis revealed Trans-Anethole (80.63%), L-Fenchone (11.57%), Estragole (3.67%) and Limonene (2.68%) were the major compounds of the essential oil. Antibacterial activity of the essential oil against nine Gram-positive and Gram-negative strains was studied using ...
DOI:: 10.1080/14786419.2017.1423310
: https://doi.org/10.1080/14786419.2017.1423310

26. Analytical methods to access the chemical composition of an Euphorbia tirucalli anticancer latex from traditional Brazilian medicine

Author:: Larissa Silva de Souza; Letícia C. Puziol; Cristina Luz Tosta; Milena L.F. Bittencourt; Juliana Santa Ardisson; Rodrigo Rezende Kitagawa; Paulo Roberto Filgueiras; Ricardo Machado Kuster
Source:: Journal of ethnopharmacology 2019 v.237 pp. 255-265
ISSN:: 0378-8741
Subject:: Euphorbia tirucalli; adenocarcinoma; antineoplastic activity; atmospheric pressure; chemical composition; chemical constituents of plants; commercialization; cytotoxicity; diterpenoids; esters; gas chromatography-mass spectrometry; hexane; immunomodulators; inhibitory concentration 50; interleukin-6; ionization; latex; linoleic acid; macrophages; methanol; methylene chloride; monitoring; myristic acid; neoplasm cells; nitric oxide; nuclear magnetic resonance spectroscopy; oleic acid; palmitic acid; stearic acid; steroids; tandem mass spectrometry; traditional medicine; triterpenoids; tumor necrosis factor-alpha
Abstract:: ... Euphorbia tirucalli L. is widely used by Brazilian folk medicine, mainly for its anticancer activity. However, its commercialization was banned by The Brazilian National Sanitary Surveillance Agency (ANVISA) due to the presence of some compounds considered toxic, such as the diterpene esters.Aim of the study: Chemical and biological analyses were performed with the Brazilian Euphorbia tirucalli la ...
DOI:: 10.1016/j.jep.2019.03.041
: https://doi.org/10.1016/j.jep.2019.03.041

27. Anchusa azurea Mill. (Boraginaceae) aerial parts methanol extract interfering with cytoskeleton organization induces programmed cancer cells death

Author:: Jessica CeramellaThese authors have contributed equally to the manuscript.; Monica Rosa Loizzo; Domenico Iacopetta; Marco Bonesi; Vincenzo Sicari; Teresa Maria Pellicanò; Carmela Saturnino; Aurélie Malzert-Fréon; Rosa TundisJoint senior authors.; Maria Stefania Sinicropi
Source:: Food & function 2019 v.10 no.7 pp. 4280-4290
ISSN:: 2042-650X
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Anchusa azurea; aerial parts; antineoplastic activity; antioxidant activity; beta-carotene; bleaching; caffeic acid; caspase-3; catechin; cell death; cell lines; chemical composition; chlorogenic acid; cytoskeleton; death; high performance liquid chromatography; inhibitory concentration 50; menadione; methanol; mice; neoplasm cells; neoplasms; oxidative stress; toxicity
Abstract:: ... The present study aimed to determine the chemical composition, antioxidant effects and antitumor properties of a methanol extract of Anchusa azurea Mill. (Boraginaceae) aerial parts against four tumour cell lines (MCF-7, MDA-MB-231, RKO, and R₂C). The antioxidant effects were assessed by using β-carotene bleaching, 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picryl ...
DOI:: 10.1039/c9fo00582j
: https://doi.org/10.1039/c9fo00582j

28. Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin

Author:: Luan He; Yong Zhang; Naixin Kang; Yaner Wang; Ziyu Zhang; Zhengxia Zha; Shilin Yang; Qiongming Xu; Yanli Liu
Source:: Phytomedicine 2019 v.56 pp. 136-146
ISSN:: 0944-7113
Subject:: Anemone chinensis; Western blotting; adverse effects; anti-inflammatory activity; antineoplastic activity; antioxidant activity; apoptosis; blood; body weight; catalase; cell viability; cisplatin; creatinine; drug therapy; flow cytometry; glutathione; histopathology; in vivo studies; kidneys; mice; models; neoplasms; nephrotoxicity; protective effect; reactive oxygen species; renal failure; saponins; superoxide dismutase; urea nitrogen
Abstract:: ... Cisplatin is a highly effective chemotherapeutic agent commonly used in the treatment of a wide variety of malignancies. However, its clinical usage is severely limited by its serious side effects, especially nephrotoxicity. Anemoside B4, is a major saponins, rich in root of Pulsatilla chinensis (Bunge), has anti-inflammation in vitro. However, the antioxidant or anti-inflammatory effects of anemo ...
DOI:: 10.1016/j.phymed.2018.10.035
: https://doi.org/10.1016/j.phymed.2018.10.035

29. Angelica sinensis polysaccharide nanoparticles as a targeted drug delivery system for enhanced therapy of liver cancer

Author:: Yu Zhang; Zheng Cui; Hao Mei; Jingya Xu; Tao Zhou; Fang Cheng; Kaiping Wang
Source:: Carbohydrate polymers 2019 v.219 pp. 143-154
ISSN:: 0144-8617
Subject:: Angelica sinensis; antineoplastic activity; biocompatibility; deoxycholic acid; dextran; doxorubicin; drug carriers; endocytosis; hydrophobicity; image analysis; liver neoplasms; nanoparticles; pH; particle size; solubility
Abstract:: ... In recent years, the utilization of polysaccharides as targeted drug carriers has attracted considerable attention. Herein, Angelica sinensis polysaccharide (ASP), a plant polysaccharide with good biocompatibility, excellent aqueous solubility and intrinsic liver-targeted capability, was modified with hydrophobic group (deoxycholic acid) to fabricate amphiphilic conjugate (ASP-DOCA). Self-assemble ...
DOI:: 10.1016/j.carbpol.2019.04.041
: https://doi.org/10.1016/j.carbpol.2019.04.041

30. Anion Transporters Based on Noncovalent Balance including Anion−π, Hydrogen, and Halogen Bonding

Author:: Wen-Long Huang; Xu-Dong Wang; Sen Li; Rui Zhang; Yu-Fei Ao; Jun Tang; Qi-Qiang Wang; De-Xian Wang
Source:: Journal of organic chemistry 2019 v.84 no.14 pp. 8859-8869
ISSN:: 1520-6904
Subject:: antineoplastic activity; aromatic hydrocarbons; bromides; cell viability; chemical reactions; chemical structure; density functional theory; fluorescence; gallic acid; halogens; hydrogen; inhibitory concentration 50; median effective concentration; nuclear magnetic resonance spectroscopy; organic chemistry; potassium chloride; transporters; triazines
Abstract:: ... Anion transmembrane transport mediated by novel noncovalent interactions is of central interest in supramolecular chemistry. In this work, a series of oxacalix[2]arene[2]triazine-derived transporters 1 and 2 bearing anion−π-, hydrogen-, and halogen-bonding sites in rational proximity were designed and synthesized by a one-pot strategy starting from gallic acid ester derivatives and mono- or di-hal ...
DOI:: 10.1021/acs.joc.9b00561
: https://doi.org/10.1021/acs.joc.9b00561

31. Antarctic Krill (Euphausia superba) Oil: A Comprehensive Review of Chemical Composition, Extraction Technologies, Health Benefits, and Current Applications

Author:: Dan Xie; Mengyue Gong; Wei Wei; Jun Jin; Xiaosan Wang; Xingguo Wang; Qingzhe Jin
Source:: Comprehensive reviews in food science and food safety 2019 v.18 no.2 pp. 514-534
ISSN:: 1541-4337
Subject:: Euphausia superba; anti-inflammatory activity; antineoplastic activity; astaxanthin; cardiovascular diseases; dietary supplements; docosahexaenoic acid; eicosapentaenoic acid; flavonoids; ingredients; krill; minerals; neuroprotective effect; novel foods; oils; phospholipids; solvents; sterols; tocopherols; vitamin A; women's health
Abstract:: ... Antarctic krill (Euphausia superba) oil has been receiving increasing attention due to its nutritional and functional potentials. However, its application as a novel food ingredient has not yet been fully explored. This review summarizes the chemical composition, extraction technologies, potential health benefits, and current applications of krill oil, with the aim of providing suggestions for its ...
DOI:: 10.1111/1541-4337.12427
: https://doi.org/10.1111/1541-4337.12427

32. Anthocyanins/anthocyanidins and colorectal cancer: What is behind the scenes?

Author:: Luís Fernando de Sousa Moraes; Xiaofei Sun; Maria do Carmo Gouveia Peluzio; Mei-Jun Zhu
Source:: Critical reviews in food science and nutrition 2019 v.59 no.1 pp. 59-71
ISSN:: 1549-7852
Subject:: AMP-activated protein kinase; anthocyanidins; anthocyanins; anticarcinogenic activity; antineoplastic activity; antioxidants; apoptosis; carcinogenesis; cell proliferation; chemoprevention; colorectal neoplasms; death; epithelial cells; intestines; mammals; metalloproteinases; metastasis; rapamycin; transcription factor NF-kappa B
Abstract:: ... Colorectal cancer (CRC) is one of the most common cause of cancer death. Phytochemicals, especially anthocyanins/anthocyanidins (A/A), have gathered attention of the scientific community owing to their anti-inflammatory, antioxidant, and cancer-inhibitory properties. In this review, we discussed the possible mechanisms whereby A/A exhibit intestinal anticarcinogenic characteristics. Anthocyanins/a ...
DOI:: 10.1080/10408398.2017.1357533
: https://doi.org/10.1080/10408398.2017.1357533

33. Anti-Aging Effect of Agar Oligosaccharide on Male Drosophila melanogaster and Its Preliminary Mechanism

Author:: Chao Ma; Kun Yang; Yifan Wang; Xianjun Dai
Source:: Marine drugs 2019 v.17 no.11 pp. -
ISSN:: 1660-3397
Subject:: Drosophila melanogaster; agar; anti-aging properties; antineoplastic activity; antioxidant activity; catalase; gene expression regulation; genes; immunity; immunomodulators; insect reproduction; intestinal microorganisms; intestines; longevity; male fertility; males; malondialdehyde; microbial communities; midgut; oligosaccharides; prebiotics; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; ribosomal DNA; sequence analysis; vigor
Abstract:: ... Agar oligosaccharide (AOS) is a marine prebiotic with apparent anti-inflammatory, antioxidant and anti-tumor effects. During this study, different doses of AOS are added to a basal diet to evaluate its effects on the lifespan, motor vigor and reproduction of male Drosophila melanogaster. Additionally, the activities of Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and catalase (CAT) and the malondialdehy ...
DOI:: 10.3390/md17110632
PubMed:: 31698828
PubMed Central:: PMC6891751
: https://doi.org/10.3390/md17110632

34. The Anti-Cancer Effect of Mangifera indica L. Peel Extract is Associated to γH2AX-mediated Apoptosis in Colon Cancer Cells

Author:: Marianna Lauricella; Valentina Lo Galbo; Cesare Cernigliaro; Antonella Maggio; Antonio Palumbo Piccionello; Giuseppe Calvaruso; Daniela Carlisi; Sonia Emanuele; Michela Giuliano; Antonella D’Anneo
Source:: Antioxidants 2019 v.8 no.10 pp. -
ISSN:: 2076-3921
Subject:: DNA damage; Mangifera indica; antineoplastic activity; apoptosis; cell lines; cell viability; colorectal neoplasms; fibroblasts; fruit pulp; gene expression regulation; high performance liquid chromatography; histones; humans; mango peels; mangoes; mass spectrometry; mitogen-activated protein kinase; models; mutagens; neoplasm cells; phenolic compounds; phosphorylation; reactive oxygen species; signal transduction; superoxide dismutase
Abstract:: ... Ethanolic extracts from Mangifera indica L. have been proved to possess anti-tumor properties in many cancer systems. However, although most effects have been demonstrated with fruit pulp extract, the underlying molecular mechanisms of mango peel are still unclear. This study was designed to explore the effects of mango peel extract (MPE) on colon cancer cell lines. MPE affected cell viability and ...
DOI:: 10.3390/antiox8100422
PubMed:: 31546694
PubMed Central:: PMC6826946
: https://doi.org/10.3390/antiox8100422

35. Anti-Colorectal Cancer Effects of Probiotic-Derived p8 Protein

Author:: Byung Chull An; Sunwoong Hong; Ho Jin Park; Bong-Kyu Kim; Jun Young Ahn; Yongku Ryu; Jae Hyung An; Myung Jun Chung
Source:: Genes 2019 v.10 no.8 pp. -
ISSN:: 2073-4425
Subject:: antineoplastic activity; cell cycle checkpoints; cell lines; colorectal neoplasms; cytosol; endocytosis; gene therapy; in vitro studies; neoplasm cells; signal transduction; toxicity
Abstract:: ... Recently, we reported a novel therapeutic probiotic-derived protein, p8, which has anti-colorectal cancer (anti-CRC) properties. In vitro experiments using a CRC cell line (DLD-1), anti-proliferation activity (about 20%) did not improve after increasing the dose of recombinant-p8 (r-p8) to >10 μM. Here, we show that this was due to the low penetrative efficiency of r-p8 exogenous treatment. Fur ...
DOI:: 10.3390/genes10080624
PubMed:: 31430963
PubMed Central:: PMC6723380
: https://doi.org/10.3390/genes10080624

36. Anti-Neuroinflammatory Effects of Vanillin Through the Regulation of Inflammatory Factors and NF-κB Signaling in LPS-Stimulated Microglia

Author:: Mi Eun Kim; Ju Yong Na; Yong-Duk Park; Jun Sik Lee
Source:: Applied biochemistry and biotechnology 2019 v.187 no.3 pp. 884-893
ISSN:: 0273-2289
Subject:: Alzheimer disease; Parkinson disease; antineoplastic activity; central nervous system; gene expression; homeostasis; immune response; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; macrophages; messenger RNA; mitogen-activated protein kinase; necrosis; neoplasms; neuroglia; nitric oxide; phosphorylation; prostaglandin synthase; protein content; therapeutics; transcription factor NF-kappa B; tumor necrosis factor-alpha; vanilla beans; vanillin
Abstract:: ... Microglia, resident macrophages of the central nervous system (CNS), is responsible for immune responses and homeostasis of the CNS. Microglia plays a complex role in neuroinflammation, which has been implicated in neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Therefore, therapeutic agents that suppress the microglia-mediated inflammatory response could potentiall ...
DOI:: 10.1007/s12010-018-2857-5
: https://doi.org/10.1007/s12010-018-2857-5

37. Anti-Remodeling Effects of Xanthohumol-Fortified Beer in Pulmonary Arterial Hypertension Mediated by ERK and AKT Inhibition

Author:: Ana Filipa Silva; Gabriel Faria-Costa; Fábio Sousa-Nunes; Manuel Filipe Santos; Manuel João Ferreira-Pinto; Delfim Duarte; Ilda Rodrigues; João Tiago Guimarães; Adelino Leite-Moreira; Daniel Moreira-Gonçalves; Tiago Henriques-Coelho; Rita Negrão
Source:: Nutrients 2019 v.11 no.3 pp. -
ISSN:: 2072-6643
Subject:: antineoplastic activity; apoptosis; beers; cell viability; ethanol; exercise test; hemodynamics; hypertension; laboratory animals; males; mitogen-activated protein kinase; monocrotaline; pathophysiology; phenotype; polyphenols; proteins; pulmonary artery; rats; vascular endothelial growth factor receptor-2
Abstract:: ... Polyphenols present in some alcoholic beverages have been linked to beneficial effects in preventing cardiovascular diseases. Polyphenols found in beer with anti-proliferative and anti-cancer properties are appealing in the context of the quasi-malignant phenotype of pulmonary arterial hypertension (PAH). Our purpose was to evaluate if the chronic ingestion of a xanthohumol-fortified beer (FB) wou ...
DOI:: 10.3390/nu11030583
PubMed:: 30857304
PubMed Central:: PMC6472147
: https://doi.org/10.3390/nu11030583

38. Anti-biofilm properties and immunological response of an immune molecule lectin isolated from shrimp Metapenaeus monoceros

Author:: Elumalai Preetham; Abdul Salam Rubeena; Baskaralingam Vaseeharan; Mukesh Kumar Chaurasia; Jesu Arockiaraj; Rolf Erik Olsen
Source:: Fish & shellfish immunology 2019 v.94 pp. 896-906
ISSN:: 1050-4648
Subject:: Aeromonas hydrophila; Enterococcus faecalis; Metapenaeus monoceros; Saccharomyces cerevisiae; Staphylococcus aureus; Vibrio parahaemolyticus; affinity chromatography; agarose; antibacterial properties; antineoplastic activity; bacteria; binding capacity; carbohydrate binding; confocal laser scanning microscopy; disease control; encapsulation; enzyme activity; erythrocytes; hemagglutination; hemolymph; humans; lectins; light microscopy; mannose; molecular weight; monophenol monooxygenase; pH; polyacrylamide gel electrophoresis; shrimp; temperature; therapeutics; toxicity testing; yeasts
Abstract:: ... The study is carried out to understand the antimicrobial and immunological response of a potential immune molecule lectin, MmLec isolated from haemolymph of Speckled shrimp, Metapenaeus monoceros. MmLec was purified using mannose coupled Sepharose CL-4B affinity chromatography, which was further subjected on SDS-PAGE to ascertain the distribution of their molecular weight. Sugar binding specificit ...
DOI:: 10.1016/j.fsi.2019.09.032
: https://doi.org/10.1016/j.fsi.2019.09.032

39. Anti-cancer activities of S-allylmercaptocysteine from aged garlic

Author:: Yi LV; Kwok-Fai SO; Nai-Kei WONG; Jia XIAO
Source:: Chinese journal of natural medicines 2019 v.17 no.1 pp. 43-49
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; antineoplastic activity; apoptosis; dietary supplements; disease control; garlic; models; neoplasms; organic sulfur compounds
Abstract:: ... While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract (AGE) exhibits stronger anti-cancer act ...
DOI:: 10.1016/S1875-5364(19)30008-1
: https://doi.org/10.1016/S1875-5364(19)30008-1

40. Anti-cancer activity of grape seed semi-polar extracts in human mesothelioma cell lines

Author:: Francesco DI Meo; Riccardo Aversano; Gianfranco Diretto; Olivia Costantina Demurtas; Clizia Villano; Salvatore Cozzolino; Stefania Filosa; Domenico Carputo; Stefania Crispi
Source:: Journal of functional foods 2019 pp. -
ISSN:: 1756-4646
Subject:: antineoplastic activity; apoptosis; bioactive compounds; drug therapy; gene expression; grape seeds; grapes; human cell lines; mesothelioma; new drugs; proanthocyanidins; prognosis; seed extracts
Abstract:: ... Malignant mesothelioma is a tumor that affects pleural surface and has very poor prognosis. The standard therapeutic modalities for this cancer have yielded unsatisfactory outcomes, therefore the development of alternative and effective therapies is currently an urgent requirement.Grapevine is a plant rich of bioactive compounds, known for its therapeutic effects. Here, we describe the anti-cancer ...
DOI:: 10.1016/j.jff.2019.103515
: https://doi.org/10.1016/j.jff.2019.103515

41. Anti-cancer effect of Indanone-based thiazolyl hydrazone derivative on colon cancer cell lines

Author:: Silpa Narayanan; Pranav Gupta; Urooj Nazim; Mohsin Ali; Nishant Karadkhelkar; Mansoor Ahmad; Zhe-Sheng Chen
Source:: international journal of biochemistry & cell biology 2019 v.110 pp. 21-28
ISSN:: 1357-2725
Subject:: DNA topoisomerase; antineoplastic activity; antineoplastic agents; apoptosis; biphenyl; cell lines; colorectal neoplasms; hydrazine; hydrazones; indans; inhibitory concentration 50; mitosis; neoplasm cells; patients; polymerization; toxicity; tubulin; United States
Abstract:: ... Colorectal cancer is the third leading cause of cancer related deaths in the United States. Currently, Irinotecan, a topoisomerase I inhibitor, is an approved anti-cancer drug for the treatment of patients with advanced or recurrent colorectal cancer. Considering low response rate and events of high toxicity caused by irinotecan, we evaluated a series of thirteen thiazolyl hydrazone derivatives of ...
DOI:: 10.1016/j.biocel.2019.02.004
: https://doi.org/10.1016/j.biocel.2019.02.004

42. Anti-cancer effect of toosendanin and its underlying mechanisms

Author:: Sha Zhang; Liang Cao; Zong-Ren Wang; Zhe Li; Jing Ma
Source:: Journal of Asian natural products research 2019 v.21 no.3 pp. 270-283
ISSN:: 1477-2213
Subject:: Melia azedarach; antineoplastic activity; cell viability; estrogen receptors; glioblastoma; insecticides; medicinal plants; models; neoplasm cells; triterpenoids
Abstract:: ... Toosendanin (TSN) is a triterpenoid purified from the medicinal herb Melia toosendan Sieb. et Zucc and has been used as an insecticide for decades. Recent studies have attracted increasing interest of TSN due to its novel anti-cancer effect in diverse cancer models. The broad spectrum anti-cancer activity suggests that TSN inhibits multiple pathways/targets that are critical for cancer cell surviv ...
DOI:: 10.1080/10286020.2018.1451516
: https://doi.org/10.1080/10286020.2018.1451516

43. Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions

Author:: Haroon Khan; Marcella Reale; Hammad Ullah; Antoni Sureda; Silvia Tejada; Ying Wang; Zhang-Jin Zhang; Jianbo Xiao
Source:: Biotechnology advances 2019 pp. -
ISSN:: 0734-9750
Subject:: antineoplastic activity; cell lines; chemoprevention; dietary nutrient sources; mechanism of action; monitoring; neoplasm cells; neoplasms; polyphenols; signal transduction; tumor suppressor genes
Abstract:: ... The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. The aim of this review is to ...
DOI:: 10.1016/j.biotechadv.2019.04.007
: https://doi.org/10.1016/j.biotechadv.2019.04.007

44. Anti-cervical carcinoma effect of Portulaca oleracea L. polysaccharides by oral administration on intestinal dendritic cells

Author:: Rui Zhao; Xingyue Shao; Guiyan Jia; Yulan Huang; Zhe Liu; Bocui Song; Jinzuo Hou
Source:: BMC complementary and alternative medicine 2019 v.19 no.1 pp. 161
ISSN:: 1472-6882
Subject:: Portulaca oleracea; Toll-like receptor 4; Western blotting; alternative medicine; antineoplastic activity; apoptosis; calcium; carcinoma; dendritic cells; flow cytometry; homeostasis; intestines; medicinal plants; mice; mitochondria; oral administration; signal transduction; staining; toxicity testing; uterine cervical neoplasms
Abstract:: ... BACKGROUND: Cervical cancer is the second most prevalent cancer worldwide. Portulaca oleracea L. polysaccharide (POL-P3b) has been found to have enhancing immune and anti-cervical cancer activity by oral administration. Dendritic cells (DC) play a key roles in regulating intestinal immune homeostasis. In this study, we analyzed the inhibition apoptosis effects of POL-P3b on intestinal DC and relev ...
DOI:: 10.1186/s12906-019-2582-9
PubMed:: 31277622
PubMed Central:: PMC6612141
: https://doi.org/10.1186/s12906-019-2582-9

45. Anti-inflammatory activity of the sesquiterpene lactone diacethylpiptocarphol in dextransulfate sodium-induced colitis in mice

Author:: R. Sabel; A.S. Fronza; L.Z.B. Carrenho; A. Maes; M.L. Barros; L.A.E. Pollo; M.W. Biavatti; K. D'Herde; P. Vandenabeele; M.R.O. Kreuger
Source:: Journal of ethnopharmacology 2019 pp. -
ISSN:: 0378-8741
Subject:: Vernonia; anti-inflammatory activity; antineoplastic activity; body weight; colitis; interleukin-1; mechanism of action; mice; models; sesquiterpenoid lactones; traditional medicine; transcription factor NF-kappa B; transforming growth factor beta; tumor necrosis factor-alpha
Abstract:: ... Sesquiterpene lactones are organic compounds derived mainly from plants that exhibit anti-inflammatory and antitumor activities being one of the key mechanism of action of NF-kB pathway and synthesis of cytokines such as IL-1 and TNF- α.The overall objective of the present study was to evaluate the anti-inflammatory action of a sesquiterpene lactone diacethylpiptocarphol (DPC) from Vernonia scorpi ...
DOI:: 10.1016/j.jep.2019.112186
: https://doi.org/10.1016/j.jep.2019.112186

46. Anti-leukemic effects of simvastatin on NRASG12D mutant acute myeloid leukemia cells

Author:: Jiryeon Jang; Jeeyun Lee; Jun Ho Jang; Chul Won Jung; Silvia Park
Source:: Molecular biology reports 2019 v.46 no.6 pp. 5859-5866
ISSN:: 0301-4851
Subject:: Western blotting; antineoplastic activity; apoptosis; cell cycle checkpoints; cell lines; cell proliferation; cell viability; cholesterol; cytotoxicity; flow cytometry; humans; molecular biology; mutants; myeloid leukemia; simvastatin; therapeutics
Abstract:: ... The statins are a group of therapeutic drugs widely used for lowering plasma cholesterol level, while it has also been reported to induce cell death in human acute myeloid leukemia (AML) cells. To determine antitumor activity triggered by simvastatin, four AML cell lines—U937, KG1, THP1 (NRASᴳ¹²ᴰ mutant) and HL60 (NRASQ⁶¹ᴸ mutant)—were cultured with simvastatin and cell viability was assessed usin ...
DOI:: 10.1007/s11033-019-05019-8
: https://doi.org/10.1007/s11033-019-05019-8

47. Anti-pancreatic-cancer effect of a newly bred cabbage line, Amtak-ssamchae, is mediated by a reduction in regulatory-T-cell recruitment

Author:: Sunggun Kim; Soo Jeong Kim; Eun-Sang Jo; Kicheol Gil; Na-Yeon Kim; Ji Sung Park; Dongbok Park; So-Young Park; Kwang Woo Hwang
Source:: Journal of functional foods 2019 v.58 pp. 301-310
ISSN:: 1756-4646
Subject:: antineoplastic activity; beta-carotene; cabbage; functional foods; immunity; in vitro studies; mechanism of action; mice; models; pancreatic neoplasms; spleen; viability
Abstract:: ... We aimed to investigate possible anticancer effects of Amtak-ssamchae (a newly bred cabbage line containing more carotenoids) in an in vitro pancreatic-tumor cell model and an in vivo model (Panc02 cells). In an in vitro assay, Amtak-ssamchae significantly reduced the viability of Panc02 cells relative to normal ssamchae. Furthermore, an Amtak-ssamchae extract significantly reduced the tumor size ...
DOI:: 10.1016/j.jff.2019.05.006
: https://doi.org/10.1016/j.jff.2019.05.006

48. Anti-proliferative effect of 8α-tigloyloxyhirsutinolide-13-O-acetate (8αTGH) isolated from Vernonia cinerea on oral squamous cell carcinoma through inhibition of STAT3 and STAT2 phosphorylation

Author:: Phisit Pouyfung; Sirinthip Choonate; Ariyaphong Wongnoppavich; Pornpimol Rongnoparut; Kongthawat Chairatvit
Source:: Phytomedicine 2019 v.52 pp. 238-246
ISSN:: 0944-7113
Subject:: Cyanthillium cinereum; Western blotting; antineoplastic activity; cell cycle checkpoints; cell growth; colorimetry; cyclins; enzyme inhibitors; flow cytometry; herbal medicines; lung neoplasms; mortality; mouth neoplasms; neoplasm cells; phosphorylation; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; sesquiterpenoids; skin diseases; squamous cell carcinoma; traditional medicine
Abstract:: ... The high mortality rate of oral cancers has stimulated the search for effective herbal medicines and their pharmacological targets. Vernonia cinerea, a perennial tropical herb, is wildly used as a traditional folk medicine for treatment of intestinal diseases and various skin diseases in addition to possessing anti-cancer activity. However, the effect of 8α-tigloyloxyhirsutinolide-13-O-acetate (8α ...
DOI:: 10.1016/j.phymed.2018.09.211
: https://doi.org/10.1016/j.phymed.2018.09.211

49. Anti-proliferative, pro-apoptotic and anti-oxidative activity of Lactobacillus and Bifidobacterium strains: A review of mechanisms and therapeutic perspectives

Author:: Adriana Nowak; Anna Paliwoda; Janusz Błasiak
Source:: Critical reviews in food science and nutrition 2019 v.59 no.21 pp. 3456-3467
ISSN:: 1549-7852
Subject:: Bifidobacterium; Lactobacillus; antineoplastic activity; antioxidant activity; antioxidant enzymes; apoptosis; bacteria; carcinogens; cell cycle; cell proliferation; molecular weight; neoplasm cells; neoplasms; proteins; reactive oxygen species; therapeutics; transition elements
Abstract:: ... Lactobacillus and Bifidobacterium strains, their isolated constituents and substances that they secrete exert various anti-cancer actions, resulting from their anti-proliferative, pro-apoptotic and anti-oxidant properties. They can express and secrete anti-oxidant enzymes, bind reactive oxygen species, release small molecular weight anti-oxidants and chelate transition metals, preventing detriment ...
DOI:: 10.1080/10408398.2018.1494539
: https://doi.org/10.1080/10408398.2018.1494539

50. Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk

Author:: Muhammad Shahid Riaz Rajoka; Haobin Zhao; Hafiza Mahreen Mehwish; Na Li; Yao Lu; Ziyang Lian; Dongyan Shao; Mingliang Jin; Qi Li; Liqing Zhao; Junling Shi
Source:: Food research international 2019 v.123 pp. 286-297
ISSN:: 0963-9969
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Lactobacillus rhamnosus; Western blotting; antineoplastic activity; antioxidant activity; apoptosis; breast milk; cell free system; cytotoxicity; free radicals; gene expression regulation; genes; human cell lines; human health; hydroxyl radicals; immune system; liquids; neoplasm cells; nutrients; pathogens; probiotics; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; superoxide anion; uterine cervical neoplasms
Abstract:: ... Lactobacilli rhamnosus has been characterized as a probiotic and plays an important role in human health by stimulating the supplement of nutrients, preventing the colonization of pathogens, and influencing the immune system. This study investigated the anticancer activity of the three Lactobacillus rhamnosus strains SHA111, SHA112, and SHA113 isolated from human breast milk. The cell-free superna ...
DOI:: 10.1016/j.foodres.2019.05.002
: https://doi.org/10.1016/j.foodres.2019.05.002

51. Anti-tumor properties of methoxylated analogues of resveratrol in malignant MCF-7 but not in non-tumorigenic MCF-10A mammary epithelial cell lines

Author:: Annick D. van den Brand; Judith Villevoye; Sandra M. Nijmeijer; Martin van den Berg; Majorie B.M. van Duursen
Source:: Toxicology 2019 v.422 pp. 35-43
ISSN:: 0300-483X
Subject:: antineoplastic activity; antineoplastic agents; breast neoplasms; breasts; cell cycle checkpoints; cell lines; cell viability; cytochrome P-450; epithelial cells; gene expression; humans; hydroxylation; interleukin-8; mammary glands; median effective concentration; models; neoplasm cells; polyphenols; pterostilbene; reporter genes; resveratrol
Abstract:: ... Resveratrol is a plant-derived polyphenol that is known for its anti-inflammatory and anti-tumorigenic properties in in vitro and in vivo models. Recent studies show that some resveratrol analogues might be more potent anti-tumor agents, which may partly be attributed to their ability to activate the aryl hydrocarbon receptor (AHR). Here, the anti-tumorigenic properties of resveratrol and structur ...
DOI:: 10.1016/j.tox.2019.04.009
: https://doi.org/10.1016/j.tox.2019.04.009

52. Anti-tumour activity of low molecular weight heparin doxorubicin nanoparticles for histone H1 high-expressive prostate cancer PC-3M cells

Author:: Shuang Zhang; Zhan-Tao Li; Man Liu; Jing-Ru Wang; Mei-Qi Xu; Zhuo-Yue Li; Xiao-Chuan Duan; Yan-Li Hao; Xiu-Chai Zheng; Hui Li; Zhen-Han Feng; Xuan Zhang
Source:: Journal of controlled release 2019 v.295 pp. 102-117
ISSN:: 0168-3659
Subject:: anticoagulant activity; antineoplastic activity; apoptosis; blood; cell lines; cell membranes; chromatin; doxorubicin; drug delivery systems; drug therapy; heparin; histones; humans; ligands; lysosomes; models; nanoparticles; neoplasm cells; prostatic neoplasms; rats
Abstract:: ... Nucleus-targeting drug delivery systems (NTDDs) deliver chemotherapeutic agents to nuclei in order to improve the efficacy of anti-tumour therapy. Histone H1 (H1) plays a key role in establishing and maintaining higher order chromatin structures and could bind to cell membranes. In the present study, we selected H1 as a target to prepare a novel H1-mediated NTDD. Low molecular weight heparin (LMHP ...
DOI:: 10.1016/j.jconrel.2018.12.034
: https://doi.org/10.1016/j.jconrel.2018.12.034

53. Anticancer Activities of Tumor-killing Nanorobots

Author:: Suping Li; Qiao Jiang; Baoquan Ding; Guangjun Nie
Source:: Trends in biotechnology 2019 v.37 no.6 pp. 573-577
ISSN:: 0167-7799
Subject:: blood coagulation; intravenous injection; equipment; neoplasms; DNA; antineoplastic activity; thrombin
Abstract:: ... Pharmaceutical uses of cancer therapeutics, such as intravenous thrombin to elicit blood coagulation, have been hampered by lack of tumor specificity. Based on rapid progress in DNA origami-based machines capable of transporting molecular payloads, DNA nanorobots have been constructed to specifically deliver therapeutic agents into tumor vessels. ...
DOI:: 10.1016/j.tibtech.2019.01.010
: https://doi.org/10.1016/j.tibtech.2019.01.010

54. Anticancer Activity of Dendriplexes against Advanced Prostate Cancer from Protumoral Peptides and Cationic Carbosilane Dendrimers

Author:: María Sánchez-Milla; Laura Muñoz-Moreno; Javier Sánchez-Nieves; Marek Malý; Rafael Gómez; María J. Carmena; F. Javier de la Mata
Source:: Biomacromolecules 2019 v.20 no.3 pp. 1224-1234
ISSN:: 1526-4602
Subject:: amino acids; antineoplastic activity; cell adhesion; cell movement; cyclic AMP; cytotoxicity; dendrimers; fibroblasts; fluorescein; hydrophobicity; metastasis; molecular models; neoplasm cells; prostatic neoplasms; rhodamines; somatoliberin; vascular endothelial growth factors; vasoactive intestinal peptide
Abstract:: ... The interaction of neuropeptides, vasoactive intestinal peptide (VIP), or growth hormone-releasing hormone (GHRH), with a cationic carbosilane dendrimer forms dendriplexes with antitumoral behavior in advanced prostate cancer cells PC3. At the concentrations used for dendriplexes formation, the free peptides were protumoral and prometastatic in advanced prostate cancer, while dendrimer only showed ...
DOI:: 10.1021/acs.biomac.8b01632
: https://doi.org/10.1021/acs.biomac.8b01632

55. Anticancer Potential of Syzygium Species: a Review

Author:: Lee Kee Chua; Chooi Ling Lim; Anna Pick Kiong Ling; Soi Moi Chye; Rhun Yian Koh
Source:: Plant foods for human nutrition 2019 v.74 no.1 pp. 18-27
ISSN:: 0921-9668
Subject:: Syzygium; adverse effects; affordability; antineoplastic activity; apoptosis; cell proliferation; chemical constituents of plants; drug therapy; nausea; neoplasms; phenolic compounds; radiotherapy; surgery; vomiting
Abstract:: ... Cancer is a preventable and treatable disease, however, the incidence rates are on the rise. Classical treatment modalities for cancer include surgery, radiotherapy and chemotherapy. However, these are associated with detrimental side effects such as nausea and emesis. Therefore, researchers currently vest interest in complementary and alternative medicines for cancer treatment and prevention. Pla ...
DOI:: 10.1007/s11130-018-0704-z
: https://doi.org/10.1007/s11130-018-0704-z

56. Anticancer activities of Zanthoxylum bungeanum seed oil on malignant melanoma

Author:: Wenwen Pang; Shan Liu; Fangting He; Xinyang Li; Baloch Saira; Tianli Zheng; Jiayi Chen; Ke Dong; Xiao-fang Pei
Source:: Journal of ethnopharmacology 2019 v.229 pp. 180-189
ISSN:: 0378-8741
Subject:: Zanthoxylum bungeanum; antineoplastic activity; apoptosis; cell cycle checkpoints; chemical composition; fatty acids; food additives; herbal medicines; interphase; melanoma; mitogen-activated protein kinase; seed oils; signal transduction; traditional medicine; transcriptomics; ultra-performance liquid chromatography
Abstract:: ... Zanthoxylum bungeanum Maxim. (ZBM), a Chinese herb medicine and food additive, has been shown to have broad-spectrum beneficial effects. However, the anticancer activities of its seed have not been reported.for the first time investigated the anti-proliferation activity of seed oil of ZBM (ZBSO) on melanoma A375 cells as well as the underlying mechanisms.The chemical composition of ZBSO was analyz ...
DOI:: 10.1016/j.jep.2018.10.012
: https://doi.org/10.1016/j.jep.2018.10.012

57. Anticancer activity of a novel glycoprotein from Camellia oleifera Abel seeds against hepatic carcinoma in vitro and in vivo

Author:: Tingting Li; Xiangyong Meng; Caie Wu; Gongjian Fan; Jing Yang; Wenting Pan
Source:: International journal of biological macromolecules 2019 v.136 pp. 284-295
ISSN:: 0141-8130
Subject:: Camellia oleifera; T-lymphocytes; Western blotting; antineoplastic activity; antineoplastic agents; apoptosis; carcinoma; caspase-3; cell cycle checkpoints; chromatography; electron microscopy; flow cytometry; fluorescence microscopy; glycoproteins; human cell lines; interferon-gamma; membrane potential; mice; mitochondrial membrane; molecular weight; pancreas; pro-apoptotic proteins; seeds; thymus gland; toxicity testing
Abstract:: ... Glycoproteins are naturally occurring biological macromolecule that possess known pharmacological properties. This study investigated the anticancer potential of a new glycoprotein, COG2a with the weight-average molecular weight of 25.9 kDa, isolated from Camellia oleifera Abel seeds by multiple column chromatography and the mechanism of anticancer action. MTT assay showed that the maximum inhibit ...
DOI:: 10.1016/j.ijbiomac.2019.06.054
: https://doi.org/10.1016/j.ijbiomac.2019.06.054

58. Anticancer activity of polymeric nanoparticles containing linoleic acid-SN38 (LA-SN38) conjugate in a murine model of colorectal cancer

Author:: Guilin Cheng; Xiaomin Zhang; Yidan Chen; Robert J. Lee; Jiangfeng Wang; Ju Yao; Yingxin Zhang; Cheng Zhang; Kaifeng Wang; Bo Yu
Source:: Colloids and surfaces 2019 v.181 pp. 822-829
ISSN:: 0927-7765
Subject:: animal models; antineoplastic activity; antineoplastic agents; apoptosis; biodegradability; blood circulation; colorectal neoplasms; composite polymers; cytotoxicity; humans; in vitro studies; linoleic acid; macrophages; nanocarriers; nanoparticles; neoplasm cells; phagocytosis; polyethylene glycol; single nucleotide polymorphism; solvents; tetrahydrofuran; titration; transmission electron microscopes; transmission electron microscopy
Abstract:: ... Biodegradable polymeric nanoparticles (NPs) have been used frequently as nanocarriers for anticancer drugs. Linoleic acid conjugated SN38 (LA-SN38)-loaded NPs (EBNPs) were developed using biodegradable poly (ethylene oxide)-poly (butylene oxide) (PEO-PBO) diblock copolymer by titration hydration method without using a toxic organic solvent. The EBNPs had high drug loading efficiency and entrapment ...
DOI:: 10.1016/j.colsurfb.2019.06.020
: https://doi.org/10.1016/j.colsurfb.2019.06.020

59. Anticancer activity of saponin isolated from Albizia lebbeck using various in vitro models

Author:: Tanvi H. Desai; Shrikant V. Joshi
Source:: Journal of ethnopharmacology 2019 v.231 pp. 494-502
ISSN:: 0378-8741
Subject:: Albizia lebbeck; absorbance; antineoplastic activity; bark; breast neoplasms; caspase-8; cell cycle; chick embryos; chickens; chromosome aberrations; chromosomes; computer software; cytotoxicity; enzyme-linked immunosorbent assay; humans; inhibitory concentration 50; leaves; lymphocytes; models; neoplasm cells; pods; prediction; saponins; seeds; staurosporine; traditional medicine; triterpenoids
Abstract:: ... Albizia lebbeck (L.) Benth. (Family: Mimosaceae) is commonly known as Sirisha in Sanskrit. The leaves and pods of A. lebbeck were claimed to be used against cancer in traditional medicine. Previous studies using bark, leaves, seeds and pods of A. lebbeck showed cytotoxic activity against hepatic, colon, larynx, cervical and breast cancer cell lines.To evaluate the anticancer activity of saponin ri ...
DOI:: 10.1016/j.jep.2018.11.004
: https://doi.org/10.1016/j.jep.2018.11.004

60. Anticancer and apoptotic activity of biologically synthesized zinc oxide nanoparticles against human colon cancer HCT-116 cell line- in vitro study

Author:: Shahnaz Majeed; Mohammed Danish; Muhammad Hisyamuddin Bin Ismail; Mohmmed Tahir Ansari; Mohamad Nasir Mohamad Ibrahim
Source:: Sustainable chemistry and pharmacy 2019 v.14 pp. 100179
ISSN:: 2352-5541
Subject:: Artocarpus heterophyllus; Fourier transform infrared spectroscopy; acridine orange; amides; amines; antineoplastic activity; apoptosis; cell lines; chromatin; color; colorectal neoplasms; energy; energy-dispersive X-ray analysis; ethidium; humans; in vitro studies; inhibitory concentration 50; leaf extracts; leaves; nanoparticles; neoplasm cells; nitrates; particle size; spectral analysis; staining; transmission electron microscopy; ultraviolet-visible spectroscopy; zinc; zinc oxide
Abstract:: ... Aim of this study was to synthesize the safe and stable zinc oxide nanoparticles (ZnONPs) from the leaves of Artocarpus heterophyllus. The alter in the color of the leaf extract dark brown upon addition of zinc nitrate Zn(NO₃) confirms the formation of Zinc Oxide nanoparticles (ZnONPs). UV-VIS spectrophotometric analysis showed lambda max at 235 nm while Fourier transform infra-red (FTIR) spectros ...
DOI:: 10.1016/j.scp.2019.100179
: https://doi.org/10.1016/j.scp.2019.100179

61. Anticancer effect of fucoidan on cell proliferation, cell cycle progression, genetic damage and apoptotic cell death in HepG2 cancer cells

Author:: Arumugam P.; Arunkumar K.; Sivakumar L.; Murugan M.; Murugan K.
Source:: Toxicology reports 2019 v.6 pp. 556-563
ISSN:: 2214-7500
Subject:: DNA damage; Turbinaria conoides; antineoplastic activity; apoptosis; cell cycle checkpoints; cell movement; cell proliferation; cell viability; comet assay; drug therapy; dyes; fluorescence microscopy; fucoidan; fucose; galactose; glucuronic acid; human cell lines; iodides; membrane potential; mitochondrial membrane; propidium; quercetin; toxicity; xylose
Abstract:: ... The centre of the attraction of this article is inevitably associated with fucoidan polymers in terms of brown seaweed such as Turbinaria conoides. Fucoidan is a sulphated polysaccharide constitutes fucose as a major principle sugar along with other monosugars such as glucuronic acid, xylose and galactose. The core value of fucoidan in terms of various cancer types were substantially exhibited thr ...
DOI:: 10.1016/j.toxrep.2019.06.005
: https://doi.org/10.1016/j.toxrep.2019.06.005

62. Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity

Author:: Shahida Parveen; Muhammad Hanif; Euphemia Leung; Kelvin K. H. Tong; Annie Yang; Jonathan Astin; Gayan H. De Zoysa; Tasha R. Steel; David Goodman; Sanam Movassaghi; Tilo Söhnel; Vijayalekshmi Sarojini; Stephen M. F. Jamieson; Christian G. Hartinger
Source:: Chemical communications 2019 v.55 no.80 pp. 12016-12019
ISSN:: 1364-548X
Subject:: DNA damage; Danio rerio; antineoplastic activity; chemical compounds; chemical reactions; cisplatin; hemolysis; mechanism of action; models; neoplasm cells; neoplasms; reactive oxygen species; toxicity
Abstract:: ... Redox-modulating anticancer drugs allow the exploitation of altered redox biology observed in many cancer cells. We discovered dinuclear Rhᴵᴵᴵ(Cp*) and Irᴵᴵᴵ(Cp*) complexes that have in vitro anticancer activity superior to cisplatin and the investigational drug IT-139, while being less toxic in haemolysis and in vivo zebrafish models. The mode of action appears to be related to DNA damage and ROS ...
DOI:: 10.1039/c9cc03822a
: https://doi.org/10.1039/c9cc03822a

63. Antimicrobial activity, mechanism of action, and methods for stabilisation of defensins as new therapeutic agents

Author:: Meri Amerikova; Ivanka Pencheva El-Tibi; Vania Maslarska; Stanislav Bozhanov; Konstantin Tachkov
Source:: Biotechnology, biotechnological equipment 2019 v.33 no.1 pp. 671-682
ISSN:: 1314-3530
Subject:: antimicrobial peptides; antimicrobial properties; antineoplastic activity; biotechnology; drug therapy; equipment; half life; immune system; mechanism of action; multiple drug resistance; nanocarriers; pH; tissue distribution
Abstract:: ... Bioactive compounds, such as antimicrobial peptides (AMPs), have increasingly been used recently to counteract the rapidly increasing incidence of bacterial resistance to usual antibiotics and chemotherapeutics. In humans, endogenous AMPs are part of the immune system and act against pathogens. Defensins compose a class of AMPs that have activity against gram-positive and -negative bacteria, virus ...
DOI:: 10.1080/13102818.2019.1611385
: https://doi.org/10.1080/13102818.2019.1611385

64. Antimicrobial and anticancer activities of Scenedesmus obliquus metabolites

Author:: Diaa A. Marrez; Mohamed M. Naguib; Yousef Y. Sultan; Aziz M. Higazy
Source:: Heliyon 2019 v.5 no.3 pp. e01404
ISSN:: 2405-8440
Subject:: Scenedesmus obliquus; antimicrobial properties; antineoplastic activity; breast neoplasms; butylated hydroxytoluene; colorectal neoplasms; cytotoxicity; ethyl ether; hepatoma; human cell lines; humans; metabolites; neoplasm cells; quercetin
Abstract:: ... This study was conducted to evaluate the antimicrobial activities and cytotoxicity of both crude extracts of Scenedesmus obliquus and their fractions. In vitro cytotoxicity assay against human hepatocellular carcinoma (HepG2), colon cancer (HCT116) and breast cancer (MCF7) cell line was monitored. The highest inhibition was observed using diethyl ether crude extract (DEE) recording between 12.5 an ...
DOI:: 10.1016/j.heliyon.2019.e01404
PubMed:: 30976685
PubMed Central:: PMC6441795
: https://doi.org/10.1016/j.heliyon.2019.e01404

65. Antimicrobial and biochemical characterization of a C-type lectin isolated from pearl spot (Etroplus suratensis)

Author:: Abdul Salam Rubeena; Mani Divya; Baskaralingam Vaseeharan; Sivashanmugam Karthikeyan; Einar Ringø; Elumalai Preetham
Source:: Fish & shellfish immunology 2019 v.87 pp. 202-211
ISSN:: 1050-4648
Subject:: Aeromonas hydrophila; Etroplus suratensis; Gram-negative bacteria; Saccharomyces cerevisiae; Vibrio parahaemolyticus; X-ray diffraction; affinity chromatography; agarose; antibacterial properties; antineoplastic activity; biofilm; blood serum; erythrocytes; fish; hemagglutination; high performance liquid chromatography; humans; lectins; light microscopy; mannose; matrix-assisted laser desorption-ionization mass spectrometry; molecular weight; polyacrylamide gel electrophoresis; shellfish; yeasts
Abstract:: ... The present study reveals purification and characterization of a C-type lectin from the serum of pearl spot, Etroplus suratensis (Es-Lec). The Es-Lec was purified by affinity chromatography with mannose coupled sepharose CL-4B column and it exhibits single band with a molecular weight of 75 kDa in SDS-PAGE. The surface morphology of purified Es-Lec displays the homogeneous nature of protein. A dis ...
DOI:: 10.1016/j.fsi.2018.12.070
: https://doi.org/10.1016/j.fsi.2018.12.070

66. Antioxidant Capacity and Cytotoxic Effects of Catechins and Resveratrol Oligomers Produced by Enzymatic Oxidation against T24 Human Urinary Bladder Cancer Cells

Author:: Claudia Lizet Meneses-Gutiérrez; Jacqueline Hernández-Damián; José Pedraza-Chaverri; Isabel Guerrero-Legarreta; Dario Iker Téllez; María Eugenia Jaramillo-Flores
Source:: Antioxidants 2019 v.8 no.7 pp. -
ISSN:: 2076-3921
Subject:: antineoplastic activity; antioxidant activity; catechin; cisplatin; copper; cytotoxicity; epicatechin; human cell lines; humans; iron; metal ions; neoplasm cells; oxidation; peroxidase; polymerization; reactive oxygen species; resveratrol; therapeutics; urinary bladder neoplasms
Abstract:: ... In this work the polymerization of catechin, epicatechin, and resveratrol was carried out through a peroxidase oxidation process in order to improve the biological activity of these phenolic compounds. The antioxidant activity of the oligomers was evaluated by their ability to scavenge reactive oxygen species (ROS) and their capacity to chelate metal ions Fe2+ and Cu2+. The antitumor effect of the ...
DOI:: 10.3390/antiox8070214
PubMed:: 31295839
PubMed Central:: PMC6680426
: https://doi.org/10.3390/antiox8070214

67. Antioxidant and anticancer effects in human hepatocarcinoma (HepG2) cells of papain-hydrolyzed sorghum kafirin hydrolysates

Author:: Shiwei Xu; Yanting Shen; Jingwen Xu; Guangyan Qi; Gengjun Chen; Weiqun Wang; Xiuzhi Sun; Yonghui Li
Source:: Journal of functional foods 2019 v.58 pp. 374-382
ISSN:: 1756-4646
Subject:: antineoplastic activity; antioxidant activity; antioxidants; cell growth; emulsions; food industry; fractionation; ground meat; hepatoma; human cell lines; hydrolysates; hydrolysis; kafirins; lipid peroxidation; oxidation; peptides; reversed-phase high performance liquid chromatography; turbidity; ultrafiltration
Abstract:: ... Peptide antioxidants are becoming increasingly popular in the food industry. This study reported antioxidant and anticancer properties of papain-hydrolyzed sorghum kafirin. The optimum hydrolysis conditions were determined to be 360 kU/g enzyme-to-substrate ratio, and 4 h of reaction time. After ultrafiltration, the 1–3 kDa hydrolysate fraction demonstrating promising antioxidative activities as w ...
DOI:: 10.1016/j.jff.2019.05.016
: https://doi.org/10.1016/j.jff.2019.05.016

68. Antioxidant and immunomodulatory activity induced by stevioside in liver damage: In vivo, in vitro and in silico assays

Author:: Sael Casas-Grajales; Erika Ramos-Tovar; Esmeralda Chávez-Estrada; Diana Alvarez-Suarez; Erika Hernández-Aquino; Karina Reyes-Gordillo; Carlos M. Cerda-García-Rojas; Javier Camacho; Víctor Tsutsumi; M. Raj Lakshman; Pablo Muriel
Source:: Life sciences 2019 v.224 pp. 187-196
ISSN:: 0024-3205
Subject:: Stevia rebaudiana; Toll-like receptors; antineoplastic activity; antioxidant activity; antioxidants; coculture; cytokines; ethanol; gene expression regulation; genes; immune response; immunomodulators; inflammation; laboratory animals; leaves; lipopolysaccharides; liver; males; protein synthesis; rats; stevioside; transcription factor NF-kappa B; tumor necrosis factor receptors
Abstract:: ... Stevioside is a diterpenoid obtained from the leaves of Stevia rebaudiana (Bertoni) that exhibits antioxidant, antifibrotic, antiglycemic and anticancer properties. Therefore, we aimed to study whether stevioside has beneficial effects in liver injury induced by long-term thioacetamide (TAA) administration and investigated the possible underlying molecular mechanism using in vivo, in vitro and in ...
DOI:: 10.1016/j.lfs.2019.03.035
PubMed:: 30890404
PubMed Central:: PMC6556435
: https://doi.org/10.1016/j.lfs.2019.03.035

69. Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes

Author:: Peng Liu; Wei Wang; Jonathan Tang; Richard P. Bowater; Yongping Bao
Source:: Food and chemical toxicology 2019 v.128 pp. 129-136
ISSN:: 0278-6915
Subject:: DNA damage; antineoplastic activity; antioxidant activity; cell death; cell viability; clinical trials; enzymes; glutathione; hepatocytes; hepatoma; human cell lines; humans; hydrogen peroxide; neoplasm cells; protective effect; risk; sulforaphane; toxicity; toxicology
Abstract:: ... Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocytes (HHL5) and hepatoma (HepG2) cells. Results showed that SFN inhibited cell viability and induced DNA strand breaks at high doses (≥20 μM). It also activated the nuclear factor (erythroid-derived 2)-l ...
DOI:: 10.1016/j.fct.2019.03.050
: https://doi.org/10.1016/j.fct.2019.03.050

70. Antioxidant, cytotoxicity and anti-tumor activity of Cordia dichotoma fruits accompanied with its volatile and sugar composition

Author:: Abeer Y. Ibrahim; Samah A. El-Newary; Gamil E. Ibrahim
Source:: Annals of agricultural science 2019 v.64 no.1 pp. 29-37
ISSN:: 0570-1783
Subject:: Cordia dichotoma; alkaloids; alpha-phellandrene; alpha-terpineol; antineoplastic activity; antineoplastic agents; antioxidant activity; ascites; body weight; bornyl acetate; butyrates; carcinoma; catechin; chemical composition; cytotoxicity; dose response; fructose; fruit pulp; fruits; gallic acid; gas chromatography-mass spectrometry; glucose; hematologic tests; high performance liquid chromatography; ions; lethal dose 50; longevity; metals; mice; phenols; quercetin; sucrose; superoxide anion; tannins; volatile compounds
Abstract:: ... The aim of the present research was to investigate the chemical composition, antioxidant and anti-tumor effects of Cordia dichotoma fruit pulp extract “CDFP-extract”. Day after intraperitoneal inoculation of Ehrlich ascites carcinoma (EAC) cells in mice, CDFP-extract was administered orally at 500 mg/kg body weight (equal to 0.10 of determined LD50) for ten consecutive days. CDFP-extract contains ...
DOI:: 10.1016/j.aoas.2019.05.008
: https://doi.org/10.1016/j.aoas.2019.05.008

71. Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, Nemania sp. UM10M, isolated from a Diseased Torreya taxifolia Leaf

Author:: Mallika Kumarihamy; Daneel Ferreira; Edward Croom Jr.; Rajnish Sahu; Babu Tekwani; Stephen Duke; Shabana Khan; Natascha Techen; N. P. Nanayakkara
Source:: Molecules 2019 v.24 no.4 pp. 777
ISSN:: 1420-3049
Subject:: Torreya; Xylariaceae; antimalarials; antineoplastic activity; antiplasmodial properties; cytochalasins; cytotoxicity; endophytes; fungi; leaves; phytotoxicity
Abstract:: ... Bioassay-guided fractionation of an EtOAc extract of the broth of the endophytic fungus Nemania sp. UM10M (Xylariaceae) isolated from a diseased Torreya taxifolia leaf afforded three known cytochalasins, 19,20-epoxycytochalasins C (1) and D (2), and 18-deoxy-19,20-epoxycytochalasin C (3). All three compounds showed potent in vitro antiplasmodial activity and phytotoxicity with no cytotoxicity to V ...
Handle:: 10113/6471075
DOI:: 10.3390/molecules24040777
PubMed:: 30795572
PubMed Central:: PMC6413121
: https://doi.org/10.3390/molecules24040777

72. Antitumor Activity of 1,18-Octadecanedioic Acid-Paclitaxel Complexed with Human Serum Albumin

Author:: Cassandra E. Callmann; Clare L. M. LeGuyader; Spencer T. Burton; Matthew P. Thompson; Robert Hennis; Christopher Barback; Niel M. Henriksen; Warren C. Chan; Matt J. Jaremko; Jin Yang; Arnold Garcia; Michael D. Burkart; Michael K. Gilson; Jeremiah D. Momper; Paul A. Bertin; Nathan C. Gianneschi
Source:: Journal of the American Chemical Society 2019 v.141 no.30 pp. 11765-11769
ISSN:: 1520-5126
Subject:: amino acids; antineoplastic activity; dicarboxylic acids; drugs; human serum albumin; humans; hydrophobicity; long chain fatty acids; maximum tolerated dose; mice; models; moieties; nanoparticles; neoplasms; paclitaxel; pharmacokinetics
Abstract:: ... We describe the design, synthesis, and antitumor activity of an 18 carbon α,ω-dicarboxylic acid monoconjugated via an ester linkage to paclitaxel (PTX). This 1,18-octadecanedioic acid-PTX (ODDA-PTX) prodrug readily forms a noncovalent complex with human serum albumin (HSA). Preservation of the terminal carboxylic acid moiety on ODDA-PTX enables binding to HSA in the same manner as native long-chai ...
DOI:: 10.1021/jacs.9b04272
PubMed:: 31317744
PubMed Central:: PMC6676409
: https://doi.org/10.1021/jacs.9b04272

73. Antitumor Effect of Lonidamine-Polypeptide-Peptide Nanoparticles in Breast Cancer Models

Author:: Ifat Cohen-Erez; Carol Issacson; Yael Lavi; Ruthy Shaco-Levy; Jammi Milam; Brenda Laster; Levi A. Gheber; Hanna Rapaport
Source:: ACS applied materials & interfaces 2019 v.11 no.36 pp. 32670-32678
ISSN:: 1944-8252
Subject:: adverse effects; animal models; antineoplastic activity; antineoplastic agents; biocompatible materials; breast neoplasms; cancer therapy; cell culture; clinical trials; cytotoxicity; drug delivery systems; freeze drying; glutamic acid; glycolysis; hepatotoxicity; intravenous injection; mitochondria; nanoparticles; neoplasm cells; pharmacokinetics; polyglutamic acid; polypeptides; solubility
Abstract:: ... Biomaterials folded into nanoparticles (NPs) can be utilized as targeted drug delivery systems for cancer therapy. NPs may provide a vehicle for the anticancer drug lonidamine (LND), which inhibits glycolysis but was suspended from use at the clinical trial stage because of its hepatotoxicity due to poor solubility and pharmacokinetic properties. The NPs prepared by coassembly of the anionic polyp ...
DOI:: 10.1021/acsami.9b09886
: https://doi.org/10.1021/acsami.9b09886

74. Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers

Author:: Hye-Ji Shin; Kyung-A Hwang; Kyung-Chul Choi
Source:: Nutrients 2019 v.11 no.1 pp. -
ISSN:: 2072-6643
Subject:: adverse effects; animal models; antineoplastic activity; apoptosis; cell proliferation; chemoprevention; curcumin; drug resistance; drug therapy; genistein; metastasis; neoplasm cells; prognosis; radiotherapy; resveratrol; surgery; thyroid gland; thyroid neoplasms; tissues
Abstract:: ... Thyroid cancers developed from the tissues of the thyroid gland are classified into papillary (PTC), follicular (FTC), medullary (MTC), and anaplastic thyroid cancer (ATC). Although thyroid cancers have been generally known as mild forms of cancer, undifferentiated MTC and ATC have a more unfavorable prognosis than differentiated PTC and FTC because they are more aggressive and early metastatic. A ...
DOI:: 10.3390/nu11010125
PubMed:: 30634497
PubMed Central:: PMC6356543
: https://doi.org/10.3390/nu11010125

75. Antitumor Potential and Phytochemical Profile of Plants from Sardinia (Italy), a Hotspot for Biodiversity in the Mediterranean Basin

Author:: Concettina Cappadone; Manuela Mandrone; Ilaria Chiocchio; Cinzia Sanna; Emil Malucelli; Vincenza Bassi; Giovanna Picone; Ferruccio Poli
Source:: Plants 2019 v.9 no.1 pp. -
ISSN:: 2223-7747
Subject:: Arbutus unedo; Centaurea calcitrapa; Cynara cardunculus; Smilax aspera; Tanacetum; antineoplastic activity; apoptosis; biodiversity; caspases; cell cycle checkpoints; chemical constituents of plants; drugs; human diseases; human umbilical vein endothelial cells; metabolites; mitosis; neoplasm cells; nuclear magnetic resonance spectroscopy; osteosarcoma; phenolic compounds; sesquiterpenoid lactones; Corsica; Italy; Mediterranean region; Sardinia
Abstract:: ... Sardinia (Italy), with its wide range of habitats and high degree of endemism, is an important area for plant-based drug discovery studies. In this work, the antitumor activity of 35 samples from Sardinian plants was evaluated on human osteosarcoma cells U2OS. The results showed that five plants were strongly antiproliferative: Arbutus unedo (AuL), Cynara cardunculus (CyaA), Centaurea calcitrapa ( ...
DOI:: 10.3390/plants9010026
: https://doi.org/10.3390/plants9010026

76. Antitumor Potential of Marine and Freshwater Lectins

Author:: Elena Catanzaro; Cinzia Calcabrini; Anupam Bishayee; Carmela Fimognari
Source:: Marine drugs 2019 v.18 no.1 pp. -
ISSN:: 1660-3397
Subject:: algae; antineoplastic activity; antineoplastic agents; biodiversity; cell death; cell proliferation; clinical trials; freshwater; glycoproteins; lectins; marine environment; neoplasm cells; neoplasms; sugars; toxicity; toxicology; vertebrates
Abstract:: ... Often, even the most effective antineoplastic drugs currently used in clinic do not efficiently allow complete healing due to the related toxicity. The reason for the toxicity lies in the lack of selectivity for cancer cells of the vast majority of anticancer agents. Thus, the need for new potent anticancer compounds characterized by a better toxicological profile is compelling. Lectins belong to ...
DOI:: 10.3390/md18010011
: https://doi.org/10.3390/md18010011

77. Antitumor activity of alantolactone in lung cancer cell lines NCI‐H1299 and Anip973

Author:: Jianli Liu; Zhijun Yang; Yuchi Kong; Yin He; Yongliang Xu; Xiangyu Cao
Source:: Journal of food biochemistry 2019 v.43 no.9 pp. e12972
ISSN:: 0145-8884
Subject:: Inula helenium; antineoplastic activity; apoptosis; carcinogenesis; cell lines; cell viability; chemoprevention; death; drug therapy; lung neoplasms; medicine; mitogen-activated protein kinase; neoplasm cells; sesquiterpenoid lactones; transcription factor NF-kappa B
Abstract:: ... Alantolactone is a sesquiterpene lactone extracted from Inula helenium L. plants possessing many biological activities, including anti‐inflammatory, antiproliferation, and antimicrobial. The inhibitory effects and the underlying mechanisms of alantolactone on lung cancer cells NCI‐H1299 and Anip973 were investigated in this study. The results showed that alantolactone could decrease cell viability ...
DOI:: 10.1111/jfbc.12972
: https://doi.org/10.1111/jfbc.12972

78. Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients

Author:: Sophia J. Lang; Michael Schmiech; Susanne Hafner; Christian Paetz; Carmen Steinborn; Roman Huber; Menna El Gaafary; Katharina Werner; Christoph Q. Schmidt; Tatiana Syrovets; Thomas Simmet
Source:: Phytomedicine 2019 v.62 pp. 152962
ISSN:: 0944-7113
Subject:: Artemisia annua; acetonitrile; active ingredients; antineoplastic activity; apoptosis; artemisinin; breast neoplasms; breasts; carbon; caspase-3; cell cycle; cell lines; cell proliferation; cell viability; chicks; chorioallantoic membrane; detection limit; epithelial cells; flow cytometry; high performance liquid chromatography; humans; lung neoplasms; lymphocytes; maceration; mammary glands; membrane potential; metastasis; mitochondrial membrane; models; neoplasm cells; nuclear magnetic resonance spectroscopy; pancreas; stable isotopes; tandem mass spectrometry
Abstract:: ... Artemisia annua L. has gained increasing attention for its anticancer activity. However, beside artemisinin, less is known about the possible bioactive ingredients of Artemisia annua and respective herbal preparations. We hypothesized that, in addition to artemisinin, Artemisia annua preparations might contain multiple ingredients with potential anticancer activity.MDA-MB-231 triple negative human ...
DOI:: 10.1016/j.phymed.2019.152962
: https://doi.org/10.1016/j.phymed.2019.152962

79. Antitumor activity of selenium modification of the bovine milk component β-Lg (Se-β-Lg) on H22 cells

Author:: Yana Zhao; Naxin Sun; Jiayue Gao; Di Wu; Anjun Liu
Source:: Food & function 2019 v.10 no.6 pp. 3626-3636
ISSN:: 2042-650X
Subject:: Western blotting; animal models; antineoplastic activity; apoptosis; caspases; cell cycle checkpoints; cytotoxicity; death domain receptors; dose response; in vitro studies; in vivo studies; interphase; liver; milk; milk composition; neoplasm cells; neoplasms; selenium; staining; tissues; toxicity testing
Abstract:: ... In this study, the apoptosis induction and antitumor activity of a novel complex, seleno-β-lactoglobulin (Se-β-Lg), on H22 cells were explored. In in vitro experiments, the MTT assay showed that Se-β-Lg was cytotoxic to H22 cells in a concentration- and time-dependent manner and displayed few proliferation inhibition effects on normal liver L02 cells. Annexin V-FITC/PI and PI staining assays showe ...
DOI:: 10.1039/c8fo02520g
: https://doi.org/10.1039/c8fo02520g

80. Antitumor effect of depsidones from lichens on tumor cell lines and experimental murine melanoma

Author:: Caroline Almeida Farias Alexandrino; Neli Kika Honda; Maria de Fatima Cepa Matos; Luciane Candeloro Portugal; Pedro Rafael Berquó de Souza; Renata Trentin Perdomo; Rita de Cássia Avellaneda Guimarães; Monica Cristina Toffoli Kadri; Magalli Costa Barbosa Lima Silva; Danielle Bogo
Source:: Revista Brasileira de Farmacognosia 2019 v.29 no.4 pp. 449-456
ISSN:: 0102-695X
Subject:: acids; antineoplastic activity; caspase-3; cell lines; flow cytometry; growth retardation; lichens; melanoma; mice; models; neoplasm cells
Abstract:: ... Lichens have exhibited numerous biological activities, including growth inhibition of tumor cells. This study evaluated the antiproliferative activity of hypostictic and salazinic acids against tumor cell lines (B16-F10, PC-03, MCF7, HT-29, HEP-G2, K562 and 786-0) by the SRB assay in vitro and antitumor activity in experimental murine melanoma in vivo. Activation of caspase-3 was quantified by flo ...
DOI:: 10.1016/j.bjp.2019.04.005
: https://doi.org/10.1016/j.bjp.2019.04.005

81. Antitumor potential of Pllans–II, an acidic Asp49–PLA2 from Porthidium lansbergii lansbergii snake venom on human cervical carcinoma HeLa cells

Author:: Eliécer Jiménez–Charris; Daiana Silva Lopes; Sarah Natalie Cirilo Gimenes; Samuel Cota Teixeira; Leonel Montealegre–Sánchez; Luis Solano–Redondo; Leonardo Fierro–Pérez; Veridiana de Melo Rodrigues Ávila
Source:: International journal of biological macromolecules 2019 v.122 pp. 1053-1061
ISSN:: 0141-8130
Subject:: angiogenesis; antineoplastic activity; apoptosis; breast neoplasms; breasts; cell cycle checkpoints; cell movement; cytotoxicity; dose response; epithelial cells; flow cytometry; genes; human cell lines; human umbilical vein endothelial cells; humans; integrins; interphase; pro-apoptotic proteins; prototypes; snake venoms; uterine cervical neoplasms
Abstract:: ... This work shows for the first time the antitumoral and angiostatic potential effects of Pllans–II, an acidic monomeric Asp49–PLA2 from Porthidium lansbergii lansbergii snake venom on HeLa cells. Pllans–II exhibited a predominant dose–dependent cytotoxicity on cervical carcinoma HeLa cells more than human breast cancer MCF7 and MDA–MB–231 cells. Interestingly, Pllans–II showed negligible effect in ...
DOI:: 10.1016/j.ijbiomac.2018.09.053
: https://doi.org/10.1016/j.ijbiomac.2018.09.053

82. Anti‐tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells

Author:: Masaya Igase; Kazuha Shousu; Noriyuki Fujiki; Masashi Sakurai; Makoto Bonkobara; Chung C. Hwang; Matt Coffey; Shunsuke Noguchi; Yuki Nemoto; Takuya Mizuno
Source:: Veterinary and comparative oncology 2019 v.17 no.2 pp. 184-193
ISSN:: 1476-5810
Subject:: Reoviridae; antineoplastic activity; apoptosis; cell lines; clinical trials; dogs; interferons; mice; neoplasm cells; prognosis; sarcoma; severe combined immunodeficiency; therapeutics
Abstract:: ... Canine histiocytic sarcoma is an aggressive, fatal neoplastic disease with a poor prognosis. Lomustine is generally accepted as the first‐line systemic therapy, although this compound does not provide complete regression. Therefore, research into a novel approach against canine histiocytic sarcoma is needed. However, anti‐tumour effects of oncolytic therapy using reovirus against histiocytic sarco ...
DOI:: 10.1111/vco.12468
: https://doi.org/10.1111/vco.12468

83. Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of β-catenin/Notch1/Akt signaling

Author:: Jia-Hong Chen; Alexander T.H Wu; David T.W Tzeng; Chi-Cheng Huang; Yew-Min Tzeng; Tsu-Yi Chao
Source:: Phytomedicine 2019 v.52 pp. 70-78
ISSN:: 0944-7113
Subject:: Taiwanofungus camphoratus; antineoplastic activity; beta catenin; bioactive compounds; breast neoplasms; breasts; carcinogenesis; clinical trials; databases; drug resistance; drugs; in vitro studies; mice; models; neoplasm cells; paclitaxel; patients; prognosis; viability
Abstract:: ... We identified increased β-catenin and Atk expression was associated with drug resistance and poor prognosis in breast cancer patients using public databases. Antrocin treatment suppressed breast tumorigenesis and stemness properties.We aimed to provide preclinical evidence for antrocin, an active component of Antrodia cinnamomea, as a potential small-molecule drug for treating drug-resistant breas ...
DOI:: 10.1016/j.phymed.2018.09.213
: https://doi.org/10.1016/j.phymed.2018.09.213

84. Apoptosis and G2/M cell cycle arrest induced by a timosaponin A3 from Anemarrhena asphodeloides Bunge on AsPC-1 pancreatic cancer cells

Author:: Yumi Kim; Kang-Hoon Kim; In-Seung Lee; Ji Young Park; Yun-Cheol Na; Won-Seok Chung; Hyeung-Jin Jang
Source:: Phytomedicine 2019 v.56 pp. 48-56
ISSN:: 0944-7113
Subject:: Anemarrhena asphodeloides; active ingredients; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cell growth; cell lines; cell proliferation; chemical constituents of plants; cyclins; cytotoxicity; drug therapy; ethyl acetate; genes; humans; immunoblotting; liquid chromatography; mass spectrometry; mechanism of action; metastasis; mitogen-activated protein kinase; neoplasm cells; pancreatic neoplasms; protein content; reverse transcription; saponins; solvents; viability
Abstract:: ... Timosaponin A3 (TA3), one of the active components of spirostanol saponin isolated from A. asphodeloides, is widely used as an anticancer agent in a variety of cancer cell lines. However, the research on the anticancer efficacy is very limited in human pancreatic cancer models.In this study, we investigated the molecular targets in the active components of A. asphodeloides, which showed anti-cance ...
DOI:: 10.1016/j.phymed.2018.08.006
: https://doi.org/10.1016/j.phymed.2018.08.006

85. Arginyl-glycyl-aspartic acid (RGD) containing nanostructured lipid carrier co-loaded with doxorubicin and sildenafil citrate enhanced anti-cancer effects and overcomes drug resistance

Author:: Hamed Hajipour; Marjan Ghorbani; Houman Kahroba; Farideh Mahmoodzadeh; Reza Zolfaghari Emameh; Ramezan Ali Taheri
Source:: Process biochemistry 2019 v.84 pp. 172-179
ISSN:: 1359-5113
Subject:: ABC transporters; antineoplastic activity; apoptosis; citrates; cytotoxicity; doxorubicin; drug therapy; encapsulation; endocytosis; gene expression; genes; homogenization; integrins; lipids; multiple drug resistance; neoplasms
Abstract:: ... Resistance to anticancer agents is considered as the main cause of chemotherapy failure. This study is aimed to prepare and optimize [Doxorubicin (Dox) + Sildenafil citrate (SC)]-coloaded Arginyl-glycyl-aspartic acid (RGD)-containing nanostructured lipid carriers (NLC-RGD) to overcome multidrug resistance limitation and improve cancer treatments. Consequently, [DOX + SC]-coloaded NLC-RGD were fabr ...
DOI:: 10.1016/j.procbio.2019.06.013
: https://doi.org/10.1016/j.procbio.2019.06.013

86. Artemisinin-resistant Leishmania parasite modulates host cell defense mechanism and exhibits altered expression of unfolded protein response genes

Author:: Aditya Verma; Sushmita Ghosh; Poonam Salotra; Ruchi Singh
Source:: Parasitology research 2019 v.118 no.9 pp. 2705-2713
ISSN:: 0932-0113
Subject:: Artemisia annua; Leishmania donovani; Plasmodium falciparum; antineoplastic activity; artemisinin; complement; cutaneous leishmaniasis; falciparum malaria; gene expression; gene expression regulation; genes; interleukin-10; interleukin-2; macrophages; medicinal plants; methyltransferases; models; nitric oxide; parasites; unfolded protein response
Abstract:: ... Artemisinin, extracted from a medicinal herb Artemisia annua, is widely used to treat malaria and has shown potent anticancer activity. Artemisinin has been found to be effective against experimental visceral and cutaneous leishmaniasis. Despite extensive research to understand the complex mechanism of resistance to artemisinin, several questions remain unanswered. The artesunate (ART)-resistant l ...
DOI:: 10.1007/s00436-019-06404-9
: https://doi.org/10.1007/s00436-019-06404-9

87. Ascochlorin induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages

Author:: Junyoung Park; Hee-Do Kim; Sook-Hyun Lee; Choong-Hwan Kwak; Young-Chae Chang; Young-Choon Lee; Tae-Wook Chung; Junji Magae; Cheorl-Ho Kim
Source:: Journal of ethnopharmacology 2019 v.239 pp. 111898
ISSN:: 0378-8741
Subject:: Ascochyta; Pisum sativum; antibiotics; antineoplastic activity; antineoplastic agents; apoptosis; blight; caspase-3; caspase-8; cell viability; colorectal neoplasms; enzyme inhibitors; flow cytometry; fungi; macrophages; necroptosis; neoplasm cells; peas; staining; traditional medicine; trypanosomiasis
Abstract:: ... Plant-specific fungus of natural compound of Ascochyta viciae has traditionally been used in the treatment of sleeping sickness and tumors. The anti-tumor activities of the compounds obtained from Pisum sativum L were evaluated in this study.In this study, during the prolonged incubation, treatment of the LPS-stimulated tumor-like macrophage RAW 264.7 cells with ASC exhibited the shift of anti-inf ...
DOI:: 10.1016/j.jep.2019.111898
: https://doi.org/10.1016/j.jep.2019.111898

88. Asparanin A from Asparagus officinalis L. Induces G0/G1 Cell Cycle Arrest and Apoptosis in Human Endometrial Carcinoma Ishikawa Cells via Mitochondrial and PI3K/AKT Signaling Pathways

Author:: Fan Zhang; Yuan-Yuan Zhang; Ya-Sai Sun; Run-Hui Ma; Kiran Thakur; Jian-Guo Zhang; Zhao-Jun Wei
Source:: Journal of agricultural and food chemistry 2019 v.68 no.1 pp. 213-224
ISSN:: 1520-5118
Subject:: Asparagus officinalis; antineoplastic activity; apoptosis; carcinoma; caspases; cell cycle checkpoints; cell lines; cell proliferation; clinical trials; cytochrome c; endometrium; enzyme inhibition; functional foods; human diseases; ingredients; interphase; mitochondria; phosphatidylinositol 3-kinase; signal transduction; steroid saponins; uterine neoplasms
Abstract:: ... Asparanin A (AA), a steroidal saponin from Asparagus officinalis L., has anticancer activity: however, its detailed molecular mechanisms in endometrial cancer (EC) have not been studied so far. We evaluated the anticancer activity and underlying mechanism of AA on EC cell line Ishikawa in vitro and in vivo. AA inhibited the Ishikawa cell proliferation and caused cell morphology alteration and cell ...
DOI:: 10.1021/acs.jafc.9b07103
: https://doi.org/10.1021/acs.jafc.9b07103

89. Aspergillus nidulans thermostable Arginine deiminase-Dextran conjugates with enhanced molecular stability, proteolytic resistance, pharmacokinetic properties and anticancer activity

Author:: Ashraf S.A. El-Sayed; Ahmed A. Shindia; Azza A. Abou Zeid; Amany M. Yassin; Mahmoud Z. Sitohy; Basel Sitohy
Source:: Enzyme and microbial technology 2019 pp. -
ISSN:: 0141-0229
Subject:: Aspergillus nidulans; Mycobacterium; active sites; antineoplastic activity; arginine; arginine deiminase; blood serum; breasts; catalytic activity; citrulline; colon; dextran; half life; liver; lysine; molecular weight; neoplasm cells; pH stability; peptidase K; peptides; pharmacokinetics; proteolysis; suicide; technology; temperature; thermal stability; thiols; toxicity; trypsin
Abstract:: ... The potential anticancer activity of arginine deiminase (ADI) via deimination of L-arginine into citrulline has been extensively verified against various arginine-auxotrophic tumors, however, the higher antigenicity, structural instability and in vivo proteolysis are the major challenges that limit this enzyme from further clinical implementation. Since, this clinically applied enzyme was derived ...
DOI:: 10.1016/j.enzmictec.2019.109432
: https://doi.org/10.1016/j.enzmictec.2019.109432

90. Aspidosperma species: A review of their chemistry and biological activities

Author:: Vera Lúcia de Almeida; Cláudia Gontijo Silva; Andréia Fonseca Silva; Priscilla Rodrigues Valadares Campana; Kenn Foubert; Júlio César Dias Lopes; Luc Pieters
Source:: Journal of ethnopharmacology 2019 v.231 pp. 125-140
ISSN:: 0378-8741
Subject:: Aspidosperma; diabetes mellitus; medicinal plants; plant extracts; indole alkaloids; genes; flavonoids; mass spectrometry; hypercholesterolemia; digital libraries; aril; patents; languages; antiplasmodial properties; secondary metabolites; databases; leaves; traditional medicine; antineoplastic activity; bioactive compounds; branches; nuclear magnetic resonance spectroscopy; biosynthesis; monoterpenoids; meta-analysis; biochemical pathways; new drugs; bark; antimalarials
Abstract:: ... Species of Aspidosperma are known popularly as “peroba, guatambu, carapanaúba, pau-pereiro” and “quina”. The genus can be found in the Americas, mainly between Mexico and Argentina. Many species of Aspidosperma are used by the population in treating cardiovascular diseases, malaria, fever, diabetes and rheumatism. The phytochemical aspects of the species of the genus Aspidosperma have been studied ...
DOI:: 10.1016/j.jep.2018.10.039
: https://doi.org/10.1016/j.jep.2018.10.039

91. Association of p38MAPK‐p53‐Fas aggregation in S‐allyl cysteine mediated regulation of hepatocarcinoma

Author:: Sujan Chatterjee; Debajyoti Patra; Udipta Chakraborti; Dipanwita Sengupta; Pujita Ghosh; Anupam Basu; Gobinda Chandra Sadhukhan; Kaustav Dutta Chowdhury
Source:: Environmental toxicology 2019 v.34 no.8 pp. 928-940
ISSN:: 1520-4081
Subject:: antineoplastic activity; apoptosis; bioactive compounds; carcinoma; caspases; cell growth; cysteine; death; dietary supplements; diethylnitrosamine; enzyme activity; hepatoma; liver; mitogen-activated protein kinase; oligomerization; phosphorylation; phytochemicals
Abstract:: ... Bioactive components of dietary phytochemicals have been reported to possess antitumor activities. Evidences suggested key role of stress responsive p38MAPK in the induction of nutraceuticals mediated apoptosis in hepatocellular carcinoma (HCC). Current study demonstrated detailed molecular bagatelle associated with p38 MAPK mediated effective suppression of cell growth both in HepG2 and chemicall ...
DOI:: 10.1002/tox.22764
: https://doi.org/10.1002/tox.22764

92. Autophagy inhibitor enhance ZnPc/BSA nanoparticle induced photodynamic therapy by suppressing PD-L1 expression in osteosarcoma immunotherapy

Author:: Wei Yu; Yitian Wang; Jian Zhu; Libin Jin; Bing Liu; Kaishun Xia; Junjie Wang; Jianqing Gao; Chengzhen Liang; Huimin Tao
Source:: Biomaterials 2019 v.192 pp. 128-139
ISSN:: 0142-9612
Subject:: antineoplastic activity; autophagy; blood serum; cattle; death; immune response; immunotherapy; metastasis; models; nanoparticles; neoplasm cells; osteosarcoma; photochemotherapy; resection
Abstract:: ... Elevated expression of programmed death ligand-1 (PD-L1) on the surface of tumor cells can exhaust cytotoxic T lymphocyte cells and lead to the failure of anti-tumor immunity during the course of tumor treatment. Here, we implemented a combined regimen of tumor resection and bovine serum albumin-Zinc phthalocyanine-induced photodynamic therapy (PDT). To overcome the long-distance metastasis of ost ...
DOI:: 10.1016/j.biomaterials.2018.11.019
: https://doi.org/10.1016/j.biomaterials.2018.11.019

93. Basil polysaccharide inhibits hypoxia-induced hepatocellular carcinoma metastasis and progression through suppression of HIF-1α-mediated epithelial-mesenchymal transition

Author:: Bing Feng; Ying Zhu; Chaoyue Sun; Zuqing Su; Lipeng Tang; Caiyun Li; Guangjuan Zheng
Source:: International journal of biological macromolecules 2019 v.137 pp. 32-44
ISSN:: 0141-8130
Subject:: Fourier transform infrared spectroscopy; Ocimum basilicum; active ingredients; anaerobic conditions; antineoplastic activity; basil; beta catenin; cadherins; cytoskeleton; epithelium; ethanol; hepatoma; hypoxia; metastasis; models; neoplasm cells; polysaccharides; prognosis; ultraviolet-visible spectroscopy; vimentin
Abstract:: ... Invasion and metastasis of cancerous cells affects the treatment and prognosis of hepatocellular carcinoma (HCC). HIF-1α-induced epithelial-mesenchymal transition (EMT) is a critical process associated with cancer metastasis. Basil polysaccharide (BPS), one of the major active ingredients isolated from Basil (Ocimum basilicum L.), has been identified to possess an antitumor activity for HCC. In ou ...
DOI:: 10.1016/j.ijbiomac.2019.06.189
: https://doi.org/10.1016/j.ijbiomac.2019.06.189

94. Beneficial effects and potential risks of tomato consumption for human health: An overview

Author:: Bahare Salehi; Razieh Sharifi-Rad; Farukh Sharopov; Jacek Namiesnik; Amir Roointan; Madhu Kamle; Pradeep Kumar; Natália Martins; Javad Sharifi-Rad
Source:: Nutrition 2019 v.62 pp. 201-208
ISSN:: 0899-9007
Subject:: anti-inflammatory activity; antineoplastic activity; antioxidants; arthritis; bioactive compounds; cardiovascular diseases; environmental factors; gastroesophageal reflux; human health; hypersensitivity; irritable bowel syndrome; kidneys; nutritive value; pain; prostatic neoplasms; tomatoes; vegetable consumption
Abstract:: ... Tomato and its derived products have a very interesting nutritional value in addition to prominent antioxidant, anti-inflammatory, and anticancer activities. Tomatoes are generally quite safe to eat. However, overall consumption varies from individual to individual. Indeed, either beneficial or harmful effects of plants or their derived products are closely related to quality, including the presen ...
DOI:: 10.1016/j.nut.2019.01.012
: https://doi.org/10.1016/j.nut.2019.01.012

95. Benzyl Isothiocyanate Reduces High-Fat/High-Cholesterol/Cholic Acid Diet-Induced Non-Alcoholic Steatohepatitis by Inhibiting the Activation of NLRP3 Inflammasome (P06-084-19)

Author:: Li-Li Ko; Haw-wen Chen; Chong-Kuei Lii
Source:: Current developments in nutrition 2019 v.3 no.Supplement_1 pp. -
ISSN:: 2475-2991
Subject:: Brassicaceae; antineoplastic activity; antioxidants; benzyl isothiocyanate; blood sampling; blood serum; caspase-1; cholesterol; cholic acid; diet; fatty liver; fibrosis; histology; inflammasomes; interleukin-1beta; liver; macrophages; males; messenger RNA; mice; obesity; tissues; triacylglycerols; vegetables; Taiwan
Abstract:: ... Non-alcoholic steatohepatitis (NASH) is one kind of fatty liver disease, which is associated with obesity. Benzyl isothiocyanate (BITC), an organosulfur compound enriched in cruciferous vegetables, shows anti-inflammatory, antioxidant, and anti-tumor activities. This study examined whether BITC protects against high-fat/high-cholesterol/cholic acid diet-induced NASH and the underlying mechanisms i ...
DOI:: 10.1093/cdn/nzz031.P06-084-19
: https://doi.org/10.1093/cdn/nzz031.P06-084-19

96. Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell

Author:: Mingjiang Yao; Xiaodi Fan; Bo Yuan; Norio Takagi; Sai Liu; Xiao Han; Junguo Ren; Jianxun Liu
Source:: BMC complementary and alternative medicine 2019 v.19 no.1 pp. 216
ISSN:: 1472-6882
Subject:: Western blotting; alternative medicine; antineoplastic activity; berberine; breast neoplasms; caspase-1; cell lines; cell proliferation; cytotoxicity; dose response; females; gene expression regulation; genes; humans; inflammasomes; interleukin-18; interleukin-1alpha; interleukin-1beta; interleukin-6; lactate dehydrogenase; messenger RNA; metastasis; necrosis; purinergic receptors; quantitative polymerase chain reaction; secretion; tissue repair; tumor necrosis factor-alpha; viability
Abstract:: ... BACKGROUND: Breast cancer is still the most common malignant tumor that threatens the female’s life in the world, especially triple-negative breast cancer (TNBC), one of the most difficult subtypes. Lack of targeted therapies brings about urgent demand for novel treatments. In this study we aim to investigate the anti-tumor activity of Berberine (BBR), a Chinese plant-derived alkaloid, against the ...
DOI:: 10.1186/s12906-019-2615-4
PubMed:: 31412862
PubMed Central:: PMC6694465
: https://doi.org/10.1186/s12906-019-2615-4

97. Berberis hispanica alkaloids extract induced cell death and apoptosis in human laryngeal cancer cells Hep-2

Author:: A. Boudjlida; S. Kaci; S. Karaki; T. Benayad; P. Rocchi; D. Smati; S. Bouguerra Aouichat
Source:: South African journal of botany 2019 v.125 pp. 134-141
ISSN:: 0254-6299
Subject:: Berberis; Western blotting; antineoplastic activity; apoptosis; bark; berberine; cell cycle; color; colorimetry; cytochrome c; high performance liquid chromatography; human cell lines; humans; inhibitory concentration 50; laryngeal neoplasms; malondialdehyde; mechanism of action; neoplasm cells; roots; traditional medicine; transcription factor NF-kappa B; viability
Abstract:: ... Berberis (Barberry) species contain an important amount of alkaloids and are commonly used in traditional medicine. Alkaloids are preponderantly characterized by their numerous properties including anticancer activity. The aims of the present study were to investigate the effect and the mechanism of action of the Algerian Berberis hispanica alkaloids extract (BHAE) on Hep-2 laryngeal cancer cells. ...
DOI:: 10.1016/j.sajb.2019.04.006
: https://doi.org/10.1016/j.sajb.2019.04.006

98. Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential

Author:: Anna Hordyjewska; Aleksandra Ostapiuk; Anna Horecka; Jacek Kurzepa
Source:: Phytochemistry reviews 2019 v.18 no.3 pp. 929-951
ISSN:: 1568-7767
Subject:: Betula; antineoplastic activity; antineoplastic agents; apoptosis; bark; betulin; betulinic acid; mechanism of action; metabolites; neoplasm cells; neoplasms; oxidation; therapeutics
Abstract:: ... Betulin, a pentacyclic triterpene and a plant pentacyclic triterpene metabolite, can be found in large quantities in the outer bark of the birches (Betula, Betulaceae). Betulinic acid, obtained by betulin oxidation, is also abundantly present in nature. Both compounds show a wide spectrum of biological and pharmacological properties, such as anti-HIV, anti-inflammatory, and, considered the most im ...
DOI:: 10.1007/s11101-019-09623-1
: https://doi.org/10.1007/s11101-019-09623-1

99. Betulin and its derivatives as novel compounds with different pharmacological effects

Author:: Shayan Amiri; Sanaz Dastghaib; Mazaher Ahmadi; Parvaneh Mehrbod; Forough Khadem; Hamid Behrouj; Mohamad-Reza Aghanoori; Filip Machaj; Mahdi Ghamsari; Jakub Rosik; Andrzej Hudecki; Abbas Afkhami; Mohammad Hashemi; Marek J. Los; Pooneh Mokarram; Tayyebeh Madrakian; Saeid Ghavami
Source:: Biotechnology advances 2019 pp. -
ISSN:: 0734-9750
Subject:: antineoplastic activity; betulin; betulinic acid; cardiovascular diseases; infectious diseases; metabolic diseases; nervous system diseases
Abstract:: ... Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids which possess a wide range of pharmacological activities. Recent evidence indicates that B and BA have several properties useful for the treatment of metabolic disorders, infectious diseases, cardiovascular disorders, and neurological disorders. In the current review, we discuss B and BA structures and deriv ...
DOI:: 10.1016/j.biotechadv.2019.06.008
: https://doi.org/10.1016/j.biotechadv.2019.06.008

100. Betulinic Acid, the first lupane-type triterpenoid isolated via bioactivity-guided fractionation, and identified by spectroscopic analysis from leaves of Nyctanthes arbor-tristis: its potential biological activities in vitro assays

Author:: Birendra Nath Karan; Tapan Kumar Maity; Bikash Chandra Pal; Tanushree Singha; Snehasis Jana
Source:: Natural product research 2019 v.33 no.22 pp. 3287-3292
ISSN:: 1478-6427
Subject:: Fourier transform infrared spectroscopy; Nyctanthes arbor-tristis; anti-inflammatory activity; antineoplastic activity; antioxidant activity; betulinic acid; carbon; cytotoxicity; ethyl acetate; fractionation; human cell lines; humans; in vitro studies; inhibitory concentration 50; leaves; mass spectrometry; neoplasm cells; neoplasms; nitrites; nuclear magnetic resonance spectroscopy; spectral analysis; stable isotopes; tumor necrosis factor-alpha
Abstract:: ... Betulinic acid was first time isolated via bioactivity-guided fractionation from ethyl acetate extract of Nyctanthes arbor-tristis leaves. Its structure was established by FTIR, ¹H and ¹³C- nuclear magnetic resonance and high-resolution mass spectrometry. It had shown excellent inhibition of anti-inflammatory properties with IC₅₀ of 10.34 μg/mL (COX-1), 12.92 μg/mL (COX-2), 15.53 μg/mL (5-LOX), 15 ...
DOI:: 10.1080/14786419.2018.1470171
: https://doi.org/10.1080/14786419.2018.1470171

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1. 16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity in vivo and in vitro

2. 1‐O‐alkylglycerols from the hepatopancreas of the crab Paralithodes camtschaticus, liver of the squid Berryteuthis magister, and liver of the skate Bathyraja parmifera, and their anticancer activity on human melanoma cells

3. 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells

4. 3‐Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau

5. 4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer

6. 7-O-geranylquercetin contributes to reverse P-gp-mediated adriamycin resistance in breast cancer

7. Berberis Plants—Drifting from Farm to Food Applications, Phytotherapy, and Phytopharmacology

8. Lactobacillus acidophilus-Fermented Germinated Brown Rice Suppresses Preneoplastic Lesions of the Colon in Rats

9. AKT1-targeted proapoptotic activity of compound K in human breast cancer cells

10. Acacetin‐induced cell apoptosis in head and neck squamous cell carcinoma cells: Evidence for the role of muscarinic M3 receptor

11. Acid and light stimuli-responsive mesoporous silica nanoparticles for controlled release

12. Actinidia chinensis Planch root extract attenuates proliferation and metastasis of hepatocellular carcinoma by inhibiting epithelial-mesenchymal transition

13. Activated TNF-α/RIPK3 signaling is involved in prolonged high fat diet-stimulated hepatic inflammation and lipid accumulation: inhibition by dietary fisetin intervention

14. Ad5-EMC6 mediates antitumor activity in gastric cancer cells through the mitochondrial apoptosis pathway

15. Advances in phytochemical delivery systems for improved anticancer activity

16. AgBiS₂-TPP nanocomposite for mitochondrial targeting photodynamic therapy, photothermal therapy and bio-imaging under 808 nm NIR laser irradiation

17. Ailanthone inhibits cell growth and migration of cisplatin resistant bladder cancer cells through down-regulation of Nrf2, YAP, and c-Myc expression.

18. An Alcohol-Soluble Polysaccharide from Atractylodes macrocephala Koidz Induces Apoptosis of Eca-109 cells

19. Algae metabolites: from in vitro growth inhibitory effects to promising anticancer activity

20. Alkaloids isolated from Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae: Anticancer activity of coccinine and montanine

21. Ameliorative effects of aqueous extract of Forsythiae suspensa fruits on oxaliplatin-induced neurotoxicity in vitro and in vivo

22. Amino modified metal-organic frameworks as pH-responsive nanoplatforms for safe delivery of camptothecin

23. Amphidinol 22, a New Cytotoxic and Antifungal Amphidinol from the Dinoflagellate Amphidinium carterae

24. Amphiphilic Gemini Iridium(III) Complex as a Mitochondria-Targeted Theranostic Agent for Tumor Imaging and Photodynamic Therapy

25. Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from Foeniculum vulgare from Hamedan, Iran

26. Analytical methods to access the chemical composition of an Euphorbia tirucalli anticancer latex from traditional Brazilian medicine

27. Anchusa azurea Mill. (Boraginaceae) aerial parts methanol extract interfering with cytoskeleton organization induces programmed cancer cells death

28. Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin

29. Angelica sinensis polysaccharide nanoparticles as a targeted drug delivery system for enhanced therapy of liver cancer

30. Anion Transporters Based on Noncovalent Balance including Anion−π, Hydrogen, and Halogen Bonding

31. Antarctic Krill (Euphausia superba) Oil: A Comprehensive Review of Chemical Composition, Extraction Technologies, Health Benefits, and Current Applications

32. Anthocyanins/anthocyanidins and colorectal cancer: What is behind the scenes?

33. Anti-Aging Effect of Agar Oligosaccharide on Male Drosophila melanogaster and Its Preliminary Mechanism

34. The Anti-Cancer Effect of Mangifera indica L. Peel Extract is Associated to γH2AX-mediated Apoptosis in Colon Cancer Cells

35. Anti-Colorectal Cancer Effects of Probiotic-Derived p8 Protein

36. Anti-Neuroinflammatory Effects of Vanillin Through the Regulation of Inflammatory Factors and NF-κB Signaling in LPS-Stimulated Microglia

37. Anti-Remodeling Effects of Xanthohumol-Fortified Beer in Pulmonary Arterial Hypertension Mediated by ERK and AKT Inhibition

38. Anti-biofilm properties and immunological response of an immune molecule lectin isolated from shrimp Metapenaeus monoceros

39. Anti-cancer activities of S-allylmercaptocysteine from aged garlic

40. Anti-cancer activity of grape seed semi-polar extracts in human mesothelioma cell lines

41. Anti-cancer effect of Indanone-based thiazolyl hydrazone derivative on colon cancer cell lines

42. Anti-cancer effect of toosendanin and its underlying mechanisms

43. Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions

44. Anti-cervical carcinoma effect of Portulaca oleracea L. polysaccharides by oral administration on intestinal dendritic cells

45. Anti-inflammatory activity of the sesquiterpene lactone diacethylpiptocarphol in dextransulfate sodium-induced colitis in mice

46. Anti-leukemic effects of simvastatin on NRASG12D mutant acute myeloid leukemia cells

47. Anti-pancreatic-cancer effect of a newly bred cabbage line, Amtak-ssamchae, is mediated by a reduction in regulatory-T-cell recruitment

48. Anti-proliferative effect of 8α-tigloyloxyhirsutinolide-13-O-acetate (8αTGH) isolated from Vernonia cinerea on oral squamous cell carcinoma through inhibition of STAT3 and STAT2 phosphorylation

49. Anti-proliferative, pro-apoptotic and anti-oxidative activity of Lactobacillus and Bifidobacterium strains: A review of mechanisms and therapeutic perspectives

50. Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk

51. Anti-tumor properties of methoxylated analogues of resveratrol in malignant MCF-7 but not in non-tumorigenic MCF-10A mammary epithelial cell lines

52. Anti-tumour activity of low molecular weight heparin doxorubicin nanoparticles for histone H1 high-expressive prostate cancer PC-3M cells

53. Anticancer Activities of Tumor-killing Nanorobots

54. Anticancer Activity of Dendriplexes against Advanced Prostate Cancer from Protumoral Peptides and Cationic Carbosilane Dendrimers

55. Anticancer Potential of Syzygium Species: a Review

56. Anticancer activities of Zanthoxylum bungeanum seed oil on malignant melanoma

57. Anticancer activity of a novel glycoprotein from Camellia oleifera Abel seeds against hepatic carcinoma in vitro and in vivo

58. Anticancer activity of polymeric nanoparticles containing linoleic acid-SN38 (LA-SN38) conjugate in a murine model of colorectal cancer

59. Anticancer activity of saponin isolated from Albizia lebbeck using various in vitro models

60. Anticancer and apoptotic activity of biologically synthesized zinc oxide nanoparticles against human colon cancer HCT-116 cell line- in vitro study

61. Anticancer effect of fucoidan on cell proliferation, cell cycle progression, genetic damage and apoptotic cell death in HepG2 cancer cells

62. Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity

63. Antimicrobial activity, mechanism of action, and methods for stabilisation of defensins as new therapeutic agents

64. Antimicrobial and anticancer activities of Scenedesmus obliquus metabolites

65. Antimicrobial and biochemical characterization of a C-type lectin isolated from pearl spot (Etroplus suratensis)

66. Antioxidant Capacity and Cytotoxic Effects of Catechins and Resveratrol Oligomers Produced by Enzymatic Oxidation against T24 Human Urinary Bladder Cancer Cells

67. Antioxidant and anticancer effects in human hepatocarcinoma (HepG2) cells of papain-hydrolyzed sorghum kafirin hydrolysates

68. Antioxidant and immunomodulatory activity induced by stevioside in liver damage: In vivo, in vitro and in silico assays

69. Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes

70. Antioxidant, cytotoxicity and anti-tumor activity of Cordia dichotoma fruits accompanied with its volatile and sugar composition

60. Anticancer and apoptotic activity of biologically synthesized zinc oxide nanoparticles against human colon cancer HCT-116 cell line- in vitro study