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You searched for: Publication Year 2019 Remove constraint Publication Year: 2019 Subject antineoplastic activity Remove constraint Subject: antineoplastic activity
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1. (−)-Oleocanthal Combined with Lapatinib Treatment Synergized against HER-2 Positive Breast Cancer In Vitro and In Vivo

Author:
Abu Bakar Siddique; Hassan Y. Ebrahim; Mohamed R. Akl; Nehad M. Ayoub; Amira A. Goda; Mohamed M. Mohyeldin; Suresh K. Nagumalli; Wael M. Hananeh; Yong-Yu Liu; Sharon A. Meyer; Khalid A. El Sayed
Source:
Nutrients 2019 v.11 no.2 pp. -
ISSN:
2072-6643
Subject:
Western blotting; antibodies; antineoplastic activity; breast neoplasms; breasts; cell lines; enzyme inhibitors; epidermal growth factor receptors; epithelium; erbB-2 receptor; extra-virgin olive oil; mice; models; neoplasm cells; non-specific protein-tyrosine kinase; non-specific serine/threonine protein kinase; therapeutics; tyrosine
Abstract:
... Dysregulation of epidermal growth factor receptor (EGFR)/human epidermal growth factor-2 (HER2) family is a hallmark of aggressive breast cancer. Small-molecule tyrosine kinase inhibitors are among the most effective cancer targeted treatments. (−)-Oleocanthal (OC) is a naturally occurring phenolic secoiridoid lead from extra-virgin olive oil with documented anti-cancer activities via target ...
DOI:
10.3390/nu11020412
PubMed:
30781364
PubMed Central:
PMC6412724

2. 16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity in vivo and in vitro

Author:
Yiren Yang; Liping Long; Xinxin Zhang; Kairu Song; Da Wang; Xin Xiong; Huiyuan Gao; Luping Sha
Source:
RSC advances 2019 v.9 no.54 pp. 31758-31772
ISSN:
2046-2069
Subject:
antineoplastic activity; apoptosis; breasts; doxorubicin; glycosides; hemolysis; human cell lines; humans; hydrolysates; lungs; metastasis; mice; neoplasm cells; neoplasm progression; toxicity; triterpenoids; uterine cervical neoplasms
Abstract:
... Barrigenol-like triterpenoids (BATs) showed promising anti-tumor, anti-inflammatory and anti-Alzheimer's activities, while, the inhibitory strength was usually affected by their states with aglycones or glycosides. In order to find more BATs as new anti-tumor agents with much more efficiency, the chemical and pharmaceutical studies were carried out on the acid hydrolysate product (AHP) of Semen Ae ...
DOI:
10.1039/c9ra06015d

3. 1‐O‐alkylglycerols from the hepatopancreas of the crab Paralithodes camtschaticus, liver of the squid Berryteuthis magister, and liver of the skate Bathyraja parmifera, and their anticancer activity on human melanoma cells

Author:
Nikolay A. Latyshev; Svetlana P. Ermakova; Ekaterina V. Ermolenko; Andrey B. Imbs; Sergey P. Kasyanov; Ruslan M. Sultanov
Source:
Journal of food biochemistry 2019 v.43 no.5 pp. e12828
ISSN:
0145-8884
Subject:
Bathyraja; Paralithodes camtschatica; antineoplastic activity; aquatic organisms; crabs; cytotoxicity; hepatopancreas; human cell lines; inhibitory concentration 50; lipids; liver; melanoma; squid; therapeutics
Abstract:
... 1‐O‐alkylglycerols (AKG) are a class of natural ether lipids derived from 1‐O‐alkyl‐2,3‐diacyl‐sn‐glycerols by deacylation. In this study, 1‐O‐alkylglycerol (AKG) composition was investigated in the hepatopancreas lipids of the crab Paralithodes camtschaticus and the liver lipids of the squid Berryteuthis magister and the skate Bathyraja parmifera. One of the principal AKG in marine organisms was ...
DOI:
10.1111/jfbc.12828

4. 2,4-Dihydroxy-3′-methoxy-4′-ethoxychalcone suppresses cell proliferation and induces apoptosis of multiple myeloma via the PI3K/akt/mTOR signaling pathway

Author:
FengChen Zhu; DianMing Jiang; MingHua Zhang; Bo Zhao
Source:
Pharmaceutical biology 2019 v.57 no.1 pp. 641-648
ISSN:
1744-5116
Subject:
Caragana; NAD ADP-ribosyltransferase; Western blotting; antineoplastic activity; apoptosis; cell proliferation; cytochrome c; flow cytometry; fluorescence microscopes; in vivo studies; inhibitory concentration 50; insulin-like growth factor I; myeloma; phosphatidylinositol 3-kinase; rapamycin; signal transduction; traditional medicine
Abstract:
... Context: Caragana pruinosa Kom. (Fabaceae), a commonly used folk medicine, has been found to possess antitumor effects. However, the antiproliferative effect of 2,4-dihydroxy-3′-methoxy-4′-ethoxychalcone (DMEC) derived from C. pruinosa against multiple myeloma (MM) has never been investigated. Objective: This study systematically evaluates the antiproliferative effect of DMEC against MM cells. Mat ...
DOI:
10.1080/13880209.2019.1662814
PubMed:
31564190
PubMed Central:
PMC6781472

5. 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells

Author:
Wuguo Li; Qing Zhang; Kaotan Chen; Zhenhua Sima; Jingli Liu; Qiang Yu; Jiawei Liu
Source:
BMC complementary and alternative medicine 2019 v.19 no.1 pp. 38
ISSN:
1472-6882
Subject:
Reynoutria japonica; Western blotting; alternative medicine; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle; cell growth; cell viability; chemical structure; dose response; drug resistance; ethyl acetate; flow cytometry; gels; hepatoma; high performance liquid chromatography; humans; inhibitory concentration 50; juglone; luciferase; metastasis; nuclear magnetic resonance spectroscopy; oncogenes; phosphorylation; physicochemical properties; relapse; reporter genes; roots; signal transduction; spectral analysis; stem cells; transactivators; transcription (genetics); tyrosine
Abstract:
... BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is an oncogene constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells (CSCs). Constitutively activated STAT3 plays a pivotal role in holding cancer stemness of HCC CSCs, which are essential for hepatoma initiation, relapse, metastasis and drug resistance. Therefore, STAT3 has been validated a ...
DOI:
10.1186/s12906-019-2440-9
PubMed:
30709346
PubMed Central:
PMC6359800

6. 2-Methylpyridine-1-ium-1-sulfonate as an Inducer of Apoptosis and Cell Cycle Arrest: A comparative in vitro and Computational Study

Author:
Hamid-Reza Mohammadi-Motlagh; Reza Yarani; Mona Sadeghalvad; Elham Adham; Hassan Rasouli; Ali Mostafaie
Source:
Nutrition and cancer 2019 v.71 no.4 pp. 643-656
ISSN:
1532-7914
Subject:
Allium; DNA fragmentation; antineoplastic activity; apoptosis; bulbs; cell cycle checkpoints; computer simulation; cyclins; dose response; gastrointestinal neoplasms; human cell lines; mechanism of action; medicinal plants; medicine; neoplasm cells; phosphotransferases (kinases)
Abstract:
... “Let food be thy medicine and thy medicine be thy food” was expressed by Hippocrates and the health benefits of medicinal plants and natural products have been considered by humans since historic times. The current study aims to investigate the anti-cancer activity of 2-Methylpyridine-1-ium-1-sulfonate (MPS) isolated from bulbs of Allium hirtifolium. The MPS compound (in a dose-dependent manner) i ...
DOI:
10.1080/01635581.2018.1506495

7. 2′-Hydroxyflavanone induced changes in the proteomic profile of breast cancer cells

Author:
Lokesh D. Nagaprashantha; Jyotsana Singhal; Shireen Chikara; Gabriel Gugiu; David Horne; Sanjay Awasthi; Ravi Salgia; Sharad S. Singhal
Source:
Journal of proteomics 2019 v.192 pp. 233-245
ISSN:
1874-3919
Subject:
antineoplastic activity; antineoplastic agents; breast neoplasms; breasts; citrus fruits; epithelial cells; flavonoids; metastasis; neoplasm cells; proteins; proteomics; therapeutics; women
Abstract:
... In spite of rapid advances in understanding of signaling networks associated with the incidence and therapeutic-sensitivity, breast cancer (BC) still remains the most commonly diagnosed and prevalent cancer in women. Emergence of resistance to hormonal interventions in estrogen-receptor (ER) positive BC coupled to loss of ER expression and activation of ER-independent growth factor, heat-shock, MY ...
DOI:
10.1016/j.jprot.2018.09.005

8. 3‐Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau

Author:
Young H. Ko; Katarzyna Niedźwiecka; Margarida Casal; Peter L. Pedersen; Stanisław Ułaszewski
Source:
Yeast 2019 v.36 no.4 pp. 211-221
ISSN:
0749-503X
Subject:
Cryptococcus neoformans; adenosine triphosphate; adverse effects; algae; animal models; antimicrobial properties; antineoplastic activity; apoptosis; bromination; cancer therapy; cell movement; fungi; glucose; glycolysis; hexokinase; lactic acid; mitochondria; neoplasm cells; neoplasms; oxygen; patients; pumps; pyruvic acid; transporters
Abstract:
... 3‐Bromopyruvate (3BP) is a small, highly reactive molecule formed by bromination of pyruvate. In the year 2000, the antitumor properties of 3BP were discovered. Studies using animal models proved its high efficacy for anticancer therapy with no apparent side effects. This was also found to be the case in a limited number of cancer patients treated with 3BP. Due to the “Warburg effect,” most tumor ...
DOI:
10.1002/yea.3367

9. 3′‐Desmethylarctigenin induces G2/M cell cycle arrest and apoptosis through reactive oxygen species generation in hepatocarcinoma cells

Author:
Enxiang Zhang; Xiuling Wang; Xiaoyi Liu; Min Liang; Hongbo Hu; Shutao Yin
Source:
Phytotherapy research 2019 v.33 no.12 pp. 3218-3227
ISSN:
0951-418X
Subject:
antineoplastic activity; apoptosis; cell cycle checkpoints; chemoprevention; hepatoma; human cell lines; mice; mitochondria; models; reactive oxygen species; therapeutics; toxicity
Abstract:
... Previous studies have shown that arctigenin is a promising chemopreventive or therapeutic agent against various cancers. However, less is known about anticancer activity of 3′‐desmethylarctigenin (3′‐DMAG), which is a biotransformed product from arctigenin or arctin. In this study, we compared the anticancer activity of 3′‐DMAG with its parent compound arctigenin and demonstrated that 3′‐DMAG exer ...
DOI:
10.1002/ptr.6496

10. 4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer

Author:
Zhicong Zhao; Dongsheng Shang; Lipeng Qiu; Chang Guo; Yanyan Li; Hanqing Liu; Guoyue Yuan; Zhigang Tu
Source:
Life sciences 2019 v.238 pp. 116973
ISSN:
0024-3205
Subject:
DNA damage; antineoplastic activity; antineoplastic agents; cell senescence; drug therapy; enzymes; fluorescent antibody technique; heterocyclic nitrogen compounds; in vitro studies; in vivo studies; mice; screening; signal transduction; staining; stomach neoplasms; survival rate
Abstract:
... Gastric cancer (GC) is a common cancer with a relatively low survival rate. Cellular senescence, a potent anti-cancer mechanism, is naturally occurred, and can be induced by chemotherapeutic agents. We sought to explore new compounds against GC cells by inducing cellular senescence.Primary screening of a library of N-heterocyclic compounds identified some with potent inhibitory effects on GC cells ...
DOI:
10.1016/j.lfs.2019.116973

11. 5-Acetamido-1-(methoxybenzyl) isatin inhibits tumor cell proliferation, migration, and angiogenesis

Author:
Qian Zhang; Ying Fu; Yufan Zhao; Shanshan Cui; Jing Wang; Fengxi Liu; Yuan Yuan; Hervé Galons; Peng Yu; Yuou Teng
Source:
RSC advances 2019 v.9 no.63 pp. 36690-36698
ISSN:
2046-2069
Subject:
angiogenesis; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cell proliferation; chemotaxis; cyclins; flow cytometry; human umbilical vein endothelial cells; humans; indoles; liver neoplasms; mitochondria; neoplasm cells
Abstract:
... Indole and its derivatives are widely distributed in both animals and plants. Among its array of biological activities, the anti-tumor activity of indole has garnered much attention. Furthermore, the synthesis and activity of indole derivatives, including isatin, constitute a flourishing research topic. Previously, many isatin derivatives were synthesized by our group, and 5-acetamido-1-(methoxybe ...
DOI:
10.1039/c9ra07002h

12. 5-Fluorouracil-loaded β-cyclodextrin-carrying polymeric poly(methylmethacrylate)-coated samarium ferrite nanoparticles and their anticancer activity

Author:
M. S. Hariharan; R. Sivaraj; S. Ponsubha; R. Jagadeesh; I. V. M. V. Enoch
Source:
Journal of materials science 2019 v.54 no.6 pp. 4942-4951
ISSN:
0022-2461
Subject:
antineoplastic activity; beta-cyclodextrin; cytotoxicity; energy-dispersive X-ray analysis; ferrimagnetic materials; fluorouracil; magnetic fields; magnetic properties; nanocarriers; nanoparticles; neoplasms; polymers; samarium; spectroscopy
Abstract:
... Drug-loading on magnetic nanoparticles coated with biocompatible polymers are intriguing nanostructures for targeted delivery of anticancer drugs with the application of a magnetic field. In this paper, we report the preparation of SmFeO₃ nanoparticles and loading of the anticancer drug 5-fluorouracil on the carrier by forming host–guest complex with β-cyclodextrin. The material and the polymer ar ...
DOI:
10.1007/s10853-018-3161-z

13. 7-O-geranylquercetin contributes to reverse P-gp-mediated adriamycin resistance in breast cancer

Author:
Enxia Zhang; Jiasi Liu; Lei Shi; Xin Guo; Ze Liang; Jiaxin Zuo; Hong Xu; Huaxin Wang; Xiaohong Shu; Shanshan Huang; Shubiao Zhang; Xiaohui Kang; Yuhong Zhen
Source:
Life sciences 2019 v.238 pp. 116938
ISSN:
0024-3205
Subject:
P-glycoproteins; Western blotting; antineoplastic activity; breast neoplasms; caudal vein; computer simulation; doxorubicin; drug resistance; drug therapy; flow cytometry; fluorescence microscopes; fluorescence microscopy; gene expression regulation; genes; mice; molecular models; quantitative polymerase chain reaction; quercetin; rhodamines; tissues; toxicity testing; viability
Abstract:
... To investigate the effect of 7-O-geranylquercetin (GQ), a derivative of quercetin (Q), on reversing drug resistance in breast cancer MCF-7/ADR cells and reveal the mechanisms related to P-glycoprotein (P-gp).Cell viability was determined by MTT assay. Accumulation of adriamycin (ADR) in cells was determined by confocal fluorescence microscope and microplate reader while that of rhodamine (Rh) was ...
DOI:
10.1016/j.lfs.2019.116938

14. Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer

Author:
Oluwaseun Adebayo Bamodu; Kuang-Tai Kuo; Chun-Hua Wang; Wen-Chien Huang; Alexander T.H. Wu; Jo-Ting Tsai; Kang-Yun Lee; Chi-Tai Yeh; Liang-Shun Wang
Source:
Nutrients 2019 v.11 no.10 pp. -
ISSN:
2072-6643
Subject:
Astragalus membranaceus; active ingredients; animal models; antineoplastic activity; carcinoma; cell proliferation; cisplatin; cytotoxic T-lymphocytes; dendritic cells; immune response; immunogenicity; in vivo studies; interleukin-10; interleukin-6; lung neoplasms; macrophages; metastasis; patients; polysaccharides; quality of life; roots; therapeutics; weight loss
Abstract:
... Background: Recently, we demonstrated that Astragalus polysaccharide (PG2), the active ingredient in dried roots of astragalus membranaceus, ameliorates cancer symptom clusters and improves quality of life (QoL) in patients with metastatic disease by modulating inflammatory cascade against the background roles of inflammatory cells, including macrophages, dendritic cells (DCs), and cytotoxic T lym ...
DOI:
10.3390/nu11102264
PubMed:
31547048
PubMed Central:
PMC6836209

15. Berberis Plants—Drifting from Farm to Food Applications, Phytotherapy, and Phytopharmacology

Author:
Bahare Salehi; Zeliha Selamoglu; Bilge Sener; Mehtap Kilic; Arun Kumar Jugran; Nunziatina de Tommasi; Chiara Sinisgalli; Luigi Milella; Jovana Rajkovic; Maria Flaviana B. Morais-Braga; Camila F. Bezerra; Janaína E. Rocha; Henrique D.M. Coutinho; Adedayo Oluwaseun Ademiluyi; Zabta Khan Shinwari; Sohail Ahmad Jan; Ebru Erol; Zulfiqar Ali; Elise Adrian Ostrander; Javad Sharifi-Rad; María de la Luz Cádiz-Gurrea; Yasaman Taheri; Miquel Martorell; Antonio Segura-Carretero; William C. Cho
Source:
Foods 2019 v.8 no.10 pp. -
ISSN:
2304-8158
Subject:
Berberis; alkaloids; antimicrobial properties; antineoplastic activity; antioxidants; bioactive compounds; chemical constituents of plants; diabetes; essential oils; farms; flavorings; food industry; food preservation; fruit juices; fruits; gas chromatography; leaves; limonene; neoplasms; ocimene; oleanolic acid; p-cymene; pharmaceutical industry; phytotherapy; tannins; toxicity; Europe; Iran; Pakistan; United States
Abstract:
... The genus Berberis includes about 500 different species and commonly grown in Europe, the United States, South Asia, and some northern areas of Iran and Pakistan. Leaves and fruits can be prepared as food flavorings, juices, and teas. Phytochemical analysis of these species has reported alkaloids, tannins, phenolic compounds and oleanolic acid, among others. Moreover, p-cymene, limonene and ocimen ...
DOI:
10.3390/foods8100522
PubMed:
31652576
PubMed Central:
PMC6836240

16. Lactobacillus acidophilus-Fermented Germinated Brown Rice Suppresses Preneoplastic Lesions of the Colon in Rats

Author:
Sing-Chung Li; Han-Pei Lin; Jung-Su Chang; Chun-Kuang Shih
Source:
Nutrients 2019 v.11 no.11 pp. -
ISSN:
2072-6643
Subject:
1,2-dimethylhydrazine; B-cell lymphoma; Lactobacillus acidophilus; antineoplastic activity; apoptosis; blood serum; brown rice; carcinogenesis; caspase-3; chemoprevention; colon; colorectal neoplasms; dextran sulfate; dietary supplements; inflammation; interleukin-1beta; interleukin-6; probiotics; protective effect; rats; tumor necrosis factor-alpha; whole grain foods
Abstract:
... Colorectal cancer (CRC) is a cancer associated with chronic inflammation. Whole grains and probiotics play a protective role against CRC. Fermented grains are receiving increased attention due to their anti-inflammatory and anti-cancer activities. Our previous study found that a combination of germinated brown rice (GBR) with probiotics suppressed colorectal carcinogenesis in rats. However, the ca ...
DOI:
10.3390/nu11112718
PubMed:
31717536
PubMed Central:
PMC6893647

17. AKT1-targeted proapoptotic activity of compound K in human breast cancer cells

Author:
Eunju Choi; Eunji Kim; Ji Hye Kim; Keejung Yoon; Sunggyu Kim; Jongsung Lee; Jae Youl Cho
Source:
Journal of Ginseng Research 2019 v.43 no.4 pp. 692-698
ISSN:
1226-8453
Subject:
Panax; antineoplastic activity; apoptosis; breast neoplasms; cancer therapy; caspase-7; caspase-8; caspase-9; cell viability; death; disease severity; flow cytometry; humans; immunoblotting; intestines; metabolites; neoplasm cells; propidium; research; saponins
Abstract:
... Breast cancer is a severe disease and the second leading cause of cancer death in women worldwide. To surmount this, various diagnosis and treatment options for breast cancer have been developed. One of the most effective strategies for cancer treatment is to induce apoptosis using naturally occurring compounds. Compound K (CK) is a ginseng saponin metabolite generated by human intestinal bacteria ...
DOI:
10.1016/j.jgr.2019.07.001

18. Acacetin‐induced cell apoptosis in head and neck squamous cell carcinoma cells: Evidence for the role of muscarinic M3 receptor

Author:
Fenglin Sun; Duo Li; Cong Wang; Caixia Peng; Hong Zheng; Xiaofeng Wang
Source:
Phytotherapy research 2019 v.33 no.5 pp. 1551-1561
ISSN:
0951-418X
Subject:
antineoplastic activity; apoptosis; calcium; calcium signaling; caspase-3; caspase-9; cell lines; cell viability; cytochrome c; electron microscopy; flavones; flow cytometry; mitochondria; neoplasm cells; small interfering RNA; squamous cell carcinoma
Abstract:
... Aacacetin, a plant flavone has shown antitumor efficacy recently. However, its associated mechanisms are poorly known. We hypothesized that the muscarinic M3 receptor (M₃R), which is highly expressed in some cancer tissue, is related to the antitumor effect of acacetin in head and neck squamous cell carcinoma (HNSCC) cells. Our results showed that 12.5‐ to 200‐μM acacetin inhibited cell viability ...
DOI:
10.1002/ptr.6343

19. Achieving traceless ablation of solid tumors without recurrence by mild photothermal-chemotherapy of triple stimuli-responsive polymer–drug conjugate nanoparticles

Author:
Chang Du; Yue Ding; Jiwen Qian; Rong Zhang; Chang-Ming Dong
Source:
Journal of materials chemistry B 2019 v.7 no.3 pp. 415-432
ISSN:
2050-7518
Subject:
animals; antineoplastic activity; blood circulation; burning; drugs; fever; fluorescence; image analysis; intravenous injection; irradiation; nanoparticles; near-infrared spectroscopy; neoplasm cells; neoplasms; pH; pharmacokinetics; photothermotherapy
Abstract:
... Although photothermal therapy (PT) and photothermal-chemotherapy (PT-CT) treatments have been used to achieve complete ablation of solid tumors, they are often implemented at more than 50 °C under high intensity and using a high dose of NIR irradiation, concomitantly inducing heavy skin burning, tissue damage, and ugly scarring. Moreover, the residual tumor cells at the treated site cannot be comp ...
DOI:
10.1039/c8tb02432d

20. Acid and light stimuli-responsive mesoporous silica nanoparticles for controlled release

Author:
Mingdong Wang; Ting Wang; Dong Wang; Wei Jiang; Jiajun Fu
Source:
Journal of materials science 2019 v.54 no.8 pp. 6199-6211
ISSN:
0022-2461
Subject:
alpha-cyclodextrin; antineoplastic activity; breast neoplasms; doxorubicin; encapsulation; humans; hydrazones; irradiation; mechanization; nanoparticles; neoplasm cells; pH; porous media; silica; ultraviolet radiation
Abstract:
... We constructed a novel stimuli-responsive system, MSNPs 1, based on mechanized silica nanoparticles, in which mesoporous silica nanoparticles (MSNs) acted as nanocontainers to load cargo, and supramolecular switches consisting of hydrazone bond, azobenzene and α-cyclodextrin (α-CD) realized the controlled release of cargo molecules from MSNPs 1. In neutral solution and without UV light irradiation ...
DOI:
10.1007/s10853-019-03325-x