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You searched for: Publication Year 2019 Remove constraint Publication Year: 2019 Subject antineoplastic activity Remove constraint Subject: antineoplastic activity
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1. (−)-Oleocanthal Combined with Lapatinib Treatment Synergized against HER-2 Positive Breast Cancer In Vitro and In Vivo

Author:
Abu Bakar Siddique; Hassan Y. Ebrahim; Mohamed R. Akl; Nehad M. Ayoub; Amira A. Goda; Mohamed M. Mohyeldin; Suresh K. Nagumalli; Wael M. Hananeh; Yong-Yu Liu; Sharon A. Meyer; Khalid A. El Sayed
Source:
Nutrients 2019 v.11 no.2 pp. -
ISSN:
2072-6643
Subject:
Western blotting; antibodies; antineoplastic activity; breast neoplasms; breasts; cell lines; enzyme inhibitors; epidermal growth factor receptors; epithelium; erbB-2 receptor; extra-virgin olive oil; mice; models; neoplasm cells; non-specific protein-tyrosine kinase; non-specific serine/threonine protein kinase; therapeutics; tyrosine
Abstract:
... Dysregulation of epidermal growth factor receptor (EGFR)/human epidermal growth factor-2 (HER2) family is a hallmark of aggressive breast cancer. Small-molecule tyrosine kinase inhibitors are among the most effective cancer targeted treatments. (−)-Oleocanthal (OC) is a naturally occurring phenolic secoiridoid lead from extra-virgin olive oil with documented anti-cancer activities via target ...
DOI:
10.3390/nu11020412
PubMed:
30781364
PubMed Central:
PMC6412724

2. 16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity in vivo and in vitro

Author:
Yiren Yang; Liping Long; Xinxin Zhang; Kairu Song; Da Wang; Xin Xiong; Huiyuan Gao; Luping Sha
Source:
RSC advances 2019 v.9 no.54 pp. 31758-31772
ISSN:
2046-2069
Subject:
antineoplastic activity; apoptosis; breasts; doxorubicin; glycosides; hemolysis; human cell lines; humans; hydrolysates; lungs; metastasis; mice; neoplasm cells; neoplasm progression; toxicity; triterpenoids; uterine cervical neoplasms
Abstract:
... Barrigenol-like triterpenoids (BATs) showed promising anti-tumor, anti-inflammatory and anti-Alzheimer's activities, while, the inhibitory strength was usually affected by their states with aglycones or glycosides. In order to find more BATs as new anti-tumor agents with much more efficiency, the chemical and pharmaceutical studies were carried out on the acid hydrolysate product (AHP) of Semen Ae ...
DOI:
10.1039/c9ra06015d

3. 1‐O‐alkylglycerols from the hepatopancreas of the crab Paralithodes camtschaticus, liver of the squid Berryteuthis magister, and liver of the skate Bathyraja parmifera, and their anticancer activity on human melanoma cells

Author:
Nikolay A. Latyshev; Svetlana P. Ermakova; Ekaterina V. Ermolenko; Andrey B. Imbs; Sergey P. Kasyanov; Ruslan M. Sultanov
Source:
Journal of food biochemistry 2019 v.43 no.5 pp. e12828
ISSN:
0145-8884
Subject:
Bathyraja; Paralithodes camtschatica; antineoplastic activity; aquatic organisms; crabs; cytotoxicity; hepatopancreas; human cell lines; inhibitory concentration 50; lipids; liver; melanoma; squid; therapeutics
Abstract:
... 1‐O‐alkylglycerols (AKG) are a class of natural ether lipids derived from 1‐O‐alkyl‐2,3‐diacyl‐sn‐glycerols by deacylation. In this study, 1‐O‐alkylglycerol (AKG) composition was investigated in the hepatopancreas lipids of the crab Paralithodes camtschaticus and the liver lipids of the squid Berryteuthis magister and the skate Bathyraja parmifera. One of the principal AKG in marine organisms was ...
DOI:
10.1111/jfbc.12828

4. 2,4-Dihydroxy-3′-methoxy-4′-ethoxychalcone suppresses cell proliferation and induces apoptosis of multiple myeloma via the PI3K/akt/mTOR signaling pathway

Author:
FengChen Zhu; DianMing Jiang; MingHua Zhang; Bo Zhao
Source:
Pharmaceutical biology 2019 v.57 no.1 pp. 641-648
ISSN:
1744-5116
Subject:
Caragana; NAD ADP-ribosyltransferase; Western blotting; antineoplastic activity; apoptosis; cell proliferation; cytochrome c; flow cytometry; fluorescence microscopes; in vivo studies; inhibitory concentration 50; insulin-like growth factor I; myeloma; phosphatidylinositol 3-kinase; rapamycin; signal transduction; traditional medicine
Abstract:
... Context: Caragana pruinosa Kom. (Fabaceae), a commonly used folk medicine, has been found to possess antitumor effects. However, the antiproliferative effect of 2,4-dihydroxy-3′-methoxy-4′-ethoxychalcone (DMEC) derived from C. pruinosa against multiple myeloma (MM) has never been investigated. Objective: This study systematically evaluates the antiproliferative effect of DMEC against MM cells. Mat ...
DOI:
10.1080/13880209.2019.1662814
PubMed:
31564190
PubMed Central:
PMC6781472

5. 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells

Author:
Wuguo Li; Qing Zhang; Kaotan Chen; Zhenhua Sima; Jingli Liu; Qiang Yu; Jiawei Liu
Source:
BMC complementary and alternative medicine 2019 v.19 no.1 pp. 38
ISSN:
1472-6882
Subject:
Reynoutria japonica; Western blotting; alternative medicine; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle; cell growth; cell viability; chemical structure; dose response; drug resistance; ethyl acetate; flow cytometry; gels; hepatoma; high performance liquid chromatography; humans; inhibitory concentration 50; juglone; luciferase; metastasis; nuclear magnetic resonance spectroscopy; oncogenes; phosphorylation; physicochemical properties; relapse; reporter genes; roots; signal transduction; spectral analysis; stem cells; transactivators; transcription (genetics); tyrosine
Abstract:
... BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is an oncogene constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells (CSCs). Constitutively activated STAT3 plays a pivotal role in holding cancer stemness of HCC CSCs, which are essential for hepatoma initiation, relapse, metastasis and drug resistance. Therefore, STAT3 has been validated a ...
DOI:
10.1186/s12906-019-2440-9
PubMed:
30709346
PubMed Central:
PMC6359800

6. 2-Methylpyridine-1-ium-1-sulfonate as an Inducer of Apoptosis and Cell Cycle Arrest: A comparative in vitro and Computational Study

Author:
Hamid-Reza Mohammadi-Motlagh; Reza Yarani; Mona Sadeghalvad; Elham Adham; Hassan Rasouli; Ali Mostafaie
Source:
Nutrition and cancer 2019 v.71 no.4 pp. 643-656
ISSN:
1532-7914
Subject:
Allium; DNA fragmentation; antineoplastic activity; apoptosis; bulbs; cell cycle checkpoints; computer simulation; cyclins; dose response; gastrointestinal neoplasms; human cell lines; mechanism of action; medicinal plants; medicine; neoplasm cells; phosphotransferases (kinases)
Abstract:
... “Let food be thy medicine and thy medicine be thy food” was expressed by Hippocrates and the health benefits of medicinal plants and natural products have been considered by humans since historic times. The current study aims to investigate the anti-cancer activity of 2-Methylpyridine-1-ium-1-sulfonate (MPS) isolated from bulbs of Allium hirtifolium. The MPS compound (in a dose-dependent manner) i ...
DOI:
10.1080/01635581.2018.1506495

7. 2′-Hydroxyflavanone induced changes in the proteomic profile of breast cancer cells

Author:
Lokesh D. Nagaprashantha; Jyotsana Singhal; Shireen Chikara; Gabriel Gugiu; David Horne; Sanjay Awasthi; Ravi Salgia; Sharad S. Singhal
Source:
Journal of proteomics 2019 v.192 pp. 233-245
ISSN:
1874-3919
Subject:
antineoplastic activity; antineoplastic agents; breast neoplasms; breasts; citrus fruits; epithelial cells; flavonoids; metastasis; neoplasm cells; proteins; proteomics; therapeutics; women
Abstract:
... In spite of rapid advances in understanding of signaling networks associated with the incidence and therapeutic-sensitivity, breast cancer (BC) still remains the most commonly diagnosed and prevalent cancer in women. Emergence of resistance to hormonal interventions in estrogen-receptor (ER) positive BC coupled to loss of ER expression and activation of ER-independent growth factor, heat-shock, MY ...
DOI:
10.1016/j.jprot.2018.09.005

8. 3‐Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau

Author:
Young H. Ko; Katarzyna Niedźwiecka; Margarida Casal; Peter L. Pedersen; Stanisław Ułaszewski
Source:
Yeast 2019 v.36 no.4 pp. 211-221
ISSN:
0749-503X
Subject:
Cryptococcus neoformans; adenosine triphosphate; adverse effects; algae; animal models; antimicrobial properties; antineoplastic activity; apoptosis; bromination; cancer therapy; cell movement; fungi; glucose; glycolysis; hexokinase; lactic acid; mitochondria; neoplasm cells; neoplasms; oxygen; patients; pumps; pyruvic acid; transporters
Abstract:
... 3‐Bromopyruvate (3BP) is a small, highly reactive molecule formed by bromination of pyruvate. In the year 2000, the antitumor properties of 3BP were discovered. Studies using animal models proved its high efficacy for anticancer therapy with no apparent side effects. This was also found to be the case in a limited number of cancer patients treated with 3BP. Due to the “Warburg effect,” most tumor ...
DOI:
10.1002/yea.3367

9. 3′‐Desmethylarctigenin induces G2/M cell cycle arrest and apoptosis through reactive oxygen species generation in hepatocarcinoma cells

Author:
Enxiang Zhang; Xiuling Wang; Xiaoyi Liu; Min Liang; Hongbo Hu; Shutao Yin
Source:
Phytotherapy research 2019 v.33 no.12 pp. 3218-3227
ISSN:
0951-418X
Subject:
antineoplastic activity; apoptosis; cell cycle checkpoints; chemoprevention; hepatoma; human cell lines; mice; mitochondria; models; reactive oxygen species; therapeutics; toxicity
Abstract:
... Previous studies have shown that arctigenin is a promising chemopreventive or therapeutic agent against various cancers. However, less is known about anticancer activity of 3′‐desmethylarctigenin (3′‐DMAG), which is a biotransformed product from arctigenin or arctin. In this study, we compared the anticancer activity of 3′‐DMAG with its parent compound arctigenin and demonstrated that 3′‐DMAG exer ...
DOI:
10.1002/ptr.6496

10. 4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer

Author:
Zhicong Zhao; Dongsheng Shang; Lipeng Qiu; Chang Guo; Yanyan Li; Hanqing Liu; Guoyue Yuan; Zhigang Tu
Source:
Life sciences 2019 v.238 pp. 116973
ISSN:
0024-3205
Subject:
DNA damage; antineoplastic activity; antineoplastic agents; cell senescence; drug therapy; enzymes; fluorescent antibody technique; heterocyclic nitrogen compounds; in vitro studies; in vivo studies; mice; screening; signal transduction; staining; stomach neoplasms; survival rate
Abstract:
... Gastric cancer (GC) is a common cancer with a relatively low survival rate. Cellular senescence, a potent anti-cancer mechanism, is naturally occurred, and can be induced by chemotherapeutic agents. We sought to explore new compounds against GC cells by inducing cellular senescence.Primary screening of a library of N-heterocyclic compounds identified some with potent inhibitory effects on GC cells ...
DOI:
10.1016/j.lfs.2019.116973

11. 5-Acetamido-1-(methoxybenzyl) isatin inhibits tumor cell proliferation, migration, and angiogenesis

Author:
Qian Zhang; Ying Fu; Yufan Zhao; Shanshan Cui; Jing Wang; Fengxi Liu; Yuan Yuan; Hervé Galons; Peng Yu; Yuou Teng
Source:
RSC advances 2019 v.9 no.63 pp. 36690-36698
ISSN:
2046-2069
Subject:
angiogenesis; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cell proliferation; chemotaxis; cyclins; flow cytometry; human umbilical vein endothelial cells; humans; indoles; liver neoplasms; mitochondria; neoplasm cells
Abstract:
... Indole and its derivatives are widely distributed in both animals and plants. Among its array of biological activities, the anti-tumor activity of indole has garnered much attention. Furthermore, the synthesis and activity of indole derivatives, including isatin, constitute a flourishing research topic. Previously, many isatin derivatives were synthesized by our group, and 5-acetamido-1-(methoxybe ...
DOI:
10.1039/c9ra07002h

12. 5-Fluorouracil-loaded β-cyclodextrin-carrying polymeric poly(methylmethacrylate)-coated samarium ferrite nanoparticles and their anticancer activity

Author:
M. S. Hariharan; R. Sivaraj; S. Ponsubha; R. Jagadeesh; I. V. M. V. Enoch
Source:
Journal of materials science 2019 v.54 no.6 pp. 4942-4951
ISSN:
0022-2461
Subject:
antineoplastic activity; beta-cyclodextrin; cytotoxicity; energy-dispersive X-ray analysis; ferrimagnetic materials; fluorouracil; magnetic fields; magnetic properties; nanocarriers; nanoparticles; neoplasms; polymers; samarium; spectroscopy
Abstract:
... Drug-loading on magnetic nanoparticles coated with biocompatible polymers are intriguing nanostructures for targeted delivery of anticancer drugs with the application of a magnetic field. In this paper, we report the preparation of SmFeO₃ nanoparticles and loading of the anticancer drug 5-fluorouracil on the carrier by forming host–guest complex with β-cyclodextrin. The material and the polymer ar ...
DOI:
10.1007/s10853-018-3161-z

13. 7-O-geranylquercetin contributes to reverse P-gp-mediated adriamycin resistance in breast cancer

Author:
Enxia Zhang; Jiasi Liu; Lei Shi; Xin Guo; Ze Liang; Jiaxin Zuo; Hong Xu; Huaxin Wang; Xiaohong Shu; Shanshan Huang; Shubiao Zhang; Xiaohui Kang; Yuhong Zhen
Source:
Life sciences 2019 v.238 pp. 116938
ISSN:
0024-3205
Subject:
P-glycoproteins; Western blotting; antineoplastic activity; breast neoplasms; caudal vein; computer simulation; doxorubicin; drug resistance; drug therapy; flow cytometry; fluorescence microscopes; fluorescence microscopy; gene expression regulation; genes; mice; molecular models; quantitative polymerase chain reaction; quercetin; rhodamines; tissues; toxicity testing; viability
Abstract:
... To investigate the effect of 7-O-geranylquercetin (GQ), a derivative of quercetin (Q), on reversing drug resistance in breast cancer MCF-7/ADR cells and reveal the mechanisms related to P-glycoprotein (P-gp).Cell viability was determined by MTT assay. Accumulation of adriamycin (ADR) in cells was determined by confocal fluorescence microscope and microplate reader while that of rhodamine (Rh) was ...
DOI:
10.1016/j.lfs.2019.116938

14. Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer

Author:
Oluwaseun Adebayo Bamodu; Kuang-Tai Kuo; Chun-Hua Wang; Wen-Chien Huang; Alexander T.H. Wu; Jo-Ting Tsai; Kang-Yun Lee; Chi-Tai Yeh; Liang-Shun Wang
Source:
Nutrients 2019 v.11 no.10 pp. -
ISSN:
2072-6643
Subject:
Astragalus membranaceus; active ingredients; animal models; antineoplastic activity; carcinoma; cell proliferation; cisplatin; cytotoxic T-lymphocytes; dendritic cells; immune response; immunogenicity; in vivo studies; interleukin-10; interleukin-6; lung neoplasms; macrophages; metastasis; patients; polysaccharides; quality of life; roots; therapeutics; weight loss
Abstract:
... Background: Recently, we demonstrated that Astragalus polysaccharide (PG2), the active ingredient in dried roots of astragalus membranaceus, ameliorates cancer symptom clusters and improves quality of life (QoL) in patients with metastatic disease by modulating inflammatory cascade against the background roles of inflammatory cells, including macrophages, dendritic cells (DCs), and cytotoxic T lym ...
DOI:
10.3390/nu11102264
PubMed:
31547048
PubMed Central:
PMC6836209

15. Berberis Plants—Drifting from Farm to Food Applications, Phytotherapy, and Phytopharmacology

Author:
Bahare Salehi; Zeliha Selamoglu; Bilge Sener; Mehtap Kilic; Arun Kumar Jugran; Nunziatina de Tommasi; Chiara Sinisgalli; Luigi Milella; Jovana Rajkovic; Maria Flaviana B. Morais-Braga; Camila F. Bezerra; Janaína E. Rocha; Henrique D.M. Coutinho; Adedayo Oluwaseun Ademiluyi; Zabta Khan Shinwari; Sohail Ahmad Jan; Ebru Erol; Zulfiqar Ali; Elise Adrian Ostrander; Javad Sharifi-Rad; María de la Luz Cádiz-Gurrea; Yasaman Taheri; Miquel Martorell; Antonio Segura-Carretero; William C. Cho
Source:
Foods 2019 v.8 no.10 pp. -
ISSN:
2304-8158
Subject:
Berberis; alkaloids; antimicrobial properties; antineoplastic activity; antioxidants; bioactive compounds; chemical constituents of plants; diabetes; essential oils; farms; flavorings; food industry; food preservation; fruit juices; fruits; gas chromatography; leaves; limonene; neoplasms; ocimene; oleanolic acid; p-cymene; pharmaceutical industry; phytotherapy; tannins; toxicity; Europe; Iran; Pakistan; United States
Abstract:
... The genus Berberis includes about 500 different species and commonly grown in Europe, the United States, South Asia, and some northern areas of Iran and Pakistan. Leaves and fruits can be prepared as food flavorings, juices, and teas. Phytochemical analysis of these species has reported alkaloids, tannins, phenolic compounds and oleanolic acid, among others. Moreover, p-cymene, limonene and ocimen ...
DOI:
10.3390/foods8100522
PubMed:
31652576
PubMed Central:
PMC6836240

16. Lactobacillus acidophilus-Fermented Germinated Brown Rice Suppresses Preneoplastic Lesions of the Colon in Rats

Author:
Sing-Chung Li; Han-Pei Lin; Jung-Su Chang; Chun-Kuang Shih
Source:
Nutrients 2019 v.11 no.11 pp. -
ISSN:
2072-6643
Subject:
1,2-dimethylhydrazine; B-cell lymphoma; Lactobacillus acidophilus; antineoplastic activity; apoptosis; blood serum; brown rice; carcinogenesis; caspase-3; chemoprevention; colon; colorectal neoplasms; dextran sulfate; dietary supplements; inflammation; interleukin-1beta; interleukin-6; probiotics; protective effect; rats; tumor necrosis factor-alpha; whole grain foods
Abstract:
... Colorectal cancer (CRC) is a cancer associated with chronic inflammation. Whole grains and probiotics play a protective role against CRC. Fermented grains are receiving increased attention due to their anti-inflammatory and anti-cancer activities. Our previous study found that a combination of germinated brown rice (GBR) with probiotics suppressed colorectal carcinogenesis in rats. However, the ca ...
DOI:
10.3390/nu11112718
PubMed:
31717536
PubMed Central:
PMC6893647

17. AKT1-targeted proapoptotic activity of compound K in human breast cancer cells

Author:
Eunju Choi; Eunji Kim; Ji Hye Kim; Keejung Yoon; Sunggyu Kim; Jongsung Lee; Jae Youl Cho
Source:
Journal of Ginseng Research 2019 v.43 no.4 pp. 692-698
ISSN:
1226-8453
Subject:
Panax; antineoplastic activity; apoptosis; breast neoplasms; cancer therapy; caspase-7; caspase-8; caspase-9; cell viability; death; disease severity; flow cytometry; humans; immunoblotting; intestines; metabolites; neoplasm cells; propidium; research; saponins
Abstract:
... Breast cancer is a severe disease and the second leading cause of cancer death in women worldwide. To surmount this, various diagnosis and treatment options for breast cancer have been developed. One of the most effective strategies for cancer treatment is to induce apoptosis using naturally occurring compounds. Compound K (CK) is a ginseng saponin metabolite generated by human intestinal bacteria ...
DOI:
10.1016/j.jgr.2019.07.001

18. Acacetin‐induced cell apoptosis in head and neck squamous cell carcinoma cells: Evidence for the role of muscarinic M3 receptor

Author:
Fenglin Sun; Duo Li; Cong Wang; Caixia Peng; Hong Zheng; Xiaofeng Wang
Source:
Phytotherapy research 2019 v.33 no.5 pp. 1551-1561
ISSN:
0951-418X
Subject:
antineoplastic activity; apoptosis; calcium; calcium signaling; caspase-3; caspase-9; cell lines; cell viability; cytochrome c; electron microscopy; flavones; flow cytometry; mitochondria; neoplasm cells; small interfering RNA; squamous cell carcinoma
Abstract:
... Aacacetin, a plant flavone has shown antitumor efficacy recently. However, its associated mechanisms are poorly known. We hypothesized that the muscarinic M3 receptor (M₃R), which is highly expressed in some cancer tissue, is related to the antitumor effect of acacetin in head and neck squamous cell carcinoma (HNSCC) cells. Our results showed that 12.5‐ to 200‐μM acacetin inhibited cell viability ...
DOI:
10.1002/ptr.6343

19. Achieving traceless ablation of solid tumors without recurrence by mild photothermal-chemotherapy of triple stimuli-responsive polymer–drug conjugate nanoparticles

Author:
Chang Du; Yue Ding; Jiwen Qian; Rong Zhang; Chang-Ming Dong
Source:
Journal of materials chemistry B 2019 v.7 no.3 pp. 415-432
ISSN:
2050-7518
Subject:
animals; antineoplastic activity; blood circulation; burning; drugs; fever; fluorescence; image analysis; intravenous injection; irradiation; nanoparticles; near-infrared spectroscopy; neoplasm cells; neoplasms; pH; pharmacokinetics; photothermotherapy
Abstract:
... Although photothermal therapy (PT) and photothermal-chemotherapy (PT-CT) treatments have been used to achieve complete ablation of solid tumors, they are often implemented at more than 50 °C under high intensity and using a high dose of NIR irradiation, concomitantly inducing heavy skin burning, tissue damage, and ugly scarring. Moreover, the residual tumor cells at the treated site cannot be comp ...
DOI:
10.1039/c8tb02432d

20. Acid and light stimuli-responsive mesoporous silica nanoparticles for controlled release

Author:
Mingdong Wang; Ting Wang; Dong Wang; Wei Jiang; Jiajun Fu
Source:
Journal of materials science 2019 v.54 no.8 pp. 6199-6211
ISSN:
0022-2461
Subject:
alpha-cyclodextrin; antineoplastic activity; breast neoplasms; doxorubicin; encapsulation; humans; hydrazones; irradiation; mechanization; nanoparticles; neoplasm cells; pH; porous media; silica; ultraviolet radiation
Abstract:
... We constructed a novel stimuli-responsive system, MSNPs 1, based on mechanized silica nanoparticles, in which mesoporous silica nanoparticles (MSNs) acted as nanocontainers to load cargo, and supramolecular switches consisting of hydrazone bond, azobenzene and α-cyclodextrin (α-CD) realized the controlled release of cargo molecules from MSNPs 1. In neutral solution and without UV light irradiation ...
DOI:
10.1007/s10853-019-03325-x

21. Actinidia arguta (Hardy Kiwi) Root Extract Exerts Anti-cancer Effects via Mcl-1-Mediated Apoptosis in Cholangiocarcinoma

Author:
Xiangxuan Zhao; Feng Wen; Wei Wang; Zaiming Lu; Qiyong Guo
Source:
Nutrition and cancer 2019 v.71 no.2 pp. 246-256
ISSN:
1532-7914
Subject:
Actinidia arguta; NAD ADP-ribosyltransferase; Western blotting; antineoplastic activity; apoptosis; caspase-3; caspase-8; cell lines; cell viability; ethanol; growth retardation; liver; mice; neoplasms; patients; tissues
Abstract:
... Cholangiocarcinoma (CCA) is a highly aggressive and chemoresistant liver malignancy. Thus, identification of strategies to overcome insensitivity to apoptosis and growth inhibition is a growing focus of research in this malignancy. This study evaluated the potential anti-cancer effects of an ethanol extract from the Actinidia arguta (Hardy Kiwi) root (RAE) on CCA. Our data demonstrated that RAE de ...
DOI:
10.1080/01635581.2018.1557218

22. Actinidia chinensis Planch root extract attenuates proliferation and metastasis of hepatocellular carcinoma by inhibiting epithelial-mesenchymal transition

Author:
Tingting Fang; Yuan Fang; Xiaojing Xu; Mingyan He; Zhiying Zhao; Peixin Huang; Feifei Yuan; Mengzhou Guo; Biwei Yang; Jinglin Xia
Source:
Journal of ethnopharmacology 2019 v.231 pp. 474-485
ISSN:
0378-8741
Subject:
Actinidia chinensis; Oriental traditional medicine; animal models; antineoplastic activity; apoptosis; cell proliferation; cell viability; cytotoxicity; diuresis; gene expression; gene expression regulation; genes; hemostasis; hepatoma; herbs; messenger RNA; metastasis; patients; prognosis; quantitative polymerase chain reaction
Abstract:
... Numerous studies have demonstrated the potent anticancer activity of various Chinese herbs. Actinidia chinensis Planch root (acRoots), a traditional Chinese medicine, functions as an antitumor and detoxifying agent and plays a role in diuresis and hemostasis. Treatment with acRoots confers strong inhibition of tumor growth in various forms of cancer. Here, we evaluated the anticancer activity and ...
DOI:
10.1016/j.jep.2018.11.014

23. Activated TNF-α/RIPK3 signaling is involved in prolonged high fat diet-stimulated hepatic inflammation and lipid accumulation: inhibition by dietary fisetin intervention

Author:
Minxuan XuThese authors contributed equally to this work.; Chenxu Ge; Yuting Qin; Tingting Gu; Jinxiao Lv; Sujun Wang; Yongjie Ma; Deshuai Lou; Qiang Li; Linfeng Hu; Xuyuan Nie; Mingxing Wang; Ping Huang; Jun Tan
Source:
Food & function 2019 v.10 no.3 pp. 1302-1316
ISSN:
2042-650X
Subject:
antineoplastic activity; blood serum; fatty liver; flavonoids; gene expression; gene expression regulation; high fat diet; inflammation; lipids; liver; liver function; metabolic diseases; metabolic syndrome; mice; neoplasms; polyphenols; protective effect; protein kinases; tumor necrosis factor-alpha
Abstract:
... Increasing evidence indicates that high-fat diet (HFD) is a predisposing factor for metabolic syndrome-associated systemic inflammation and nonalcoholic fatty liver disease (NAFLD). Tumor necrosis factor-α/receptor-interacting protein kinase 3 (TNF-α/RIPK3) axis has recently become regarded as an important regulator and contributor in many inflammation-related diseases. Fisetin (Fn) is a bioactive ...
DOI:
10.1039/c8fo01615a

24. Activity of antibacterial compounds from Bacillus subtilis against cellular oncoproteins by in silico approach

Author:
Annadurai Vinothkanna; Premkumar Palanisamy; Soundarapandian Sekar
Source:
Biocatalysis and agricultural biotechnology 2019 v.18 pp. 101059
ISSN:
1878-8181
Subject:
Bacillus subtilis; antibiotics; antineoplastic activity; bacteria; caspase-3; caspase-8; databases; drugs; hydrogen bonding; neoplasms; oncogene proteins; transcription factor NF-kappa B
Abstract:
... The cellular oncoproteins Caspase-3, Caspase-8 and Nuclear Factor-kappa B (NF-κB) are the factors implicated in several cancers. Synthetic and natural compounds were demonstrated to interact with these oncoproteins. Though bacteria are the source of novel compounds including antimicrobial compounds, their anticancer activity remains elusive. Hence in this study, 10 antibacterial compounds of Bacil ...
DOI:
10.1016/j.bcab.2019.101059

25. Ad5-EMC6 mediates antitumor activity in gastric cancer cells through the mitochondrial apoptosis pathway

Author:
Riyong Li; Xiaokun Wang; Xuan Zhang; Jiahong Yu; Jinqiu Feng; Ping Lv; Yaxin Lou; Yingyu Chen
Source:
Biochemical and biophysical research communications 2019 v.513 no.3 pp. 663-668
ISSN:
0006-291X
Subject:
antineoplastic activity; apoptosis; carcinogenesis; cell growth; drug therapy; endoplasmic reticulum; etoposide; membrane potential; mice; mitochondria; mitochondrial membrane; models; neoplasm cells; stomach neoplasms; transmembrane proteins
Abstract:
... Endoplasmic reticulum membrane protein complex subunit 6 (EMC6), also known as transmembrane protein 93 (transmembrane protein 93, TMEM93), is an autophagy-related protein. EMC6 overexpression inhibits cancer cell growth and induces apoptosis, but the interaction partners of EMC6 and its cellular responsibilities remain incompletely understood. In this study, we report that adenovirus-mediated ect ...
DOI:
10.1016/j.bbrc.2019.04.023

26. Advances in phytochemical delivery systems for improved anticancer activity

Author:
Ricardo Lagoa; João Silva; Joaquim Rui Rodrigues; Anupam Bishayee
Source:
Biotechnology advances 2019 pp. -
ISSN:
0734-9750
Subject:
antineoplastic activity; berberine; bioavailability; chemical constituents of plants; colon; curcumin; drug delivery systems; flavonoids; nanoemulsions; nanoparticles; neoplasms; nose; pharmacokinetics; resveratrol
Abstract:
... Natural compounds have significant anticancer pharmacological activities, but often suffer from low bioavailability and selectivity that limit therapeutic use. The present work critically analyzes the latest advances on drug delivery systems designed to enhance pharmacokinetics, targeting, cellular uptake and efficacy of anticancer phytoconstituents. Various phytochemicals, including flavonoids, r ...
DOI:
10.1016/j.biotechadv.2019.04.004

27. AgBiS₂-TPP nanocomposite for mitochondrial targeting photodynamic therapy, photothermal therapy and bio-imaging under 808 nm NIR laser irradiation

Author:
Mingdi Sun; Dan Yang; Chen Wang; Huiting Bi; Yuan Zhou; Xiangxi Wang; Jiating Xu; Fei He; Shili Gai; Piaoping Yang
Source:
Biomaterials science 2019 v.7 no.11 pp. 4769-4781
ISSN:
2047-4849
Subject:
antineoplastic activity; bioimaging; computed tomography; energy; irradiation; mitochondria; nanocomposites; nanoparticles; near infrared radiation; near-infrared spectroscopy; neoplasm cells; neoplasms; patients; photochemotherapy; photothermotherapy; population growth; precision medicine; reactive oxygen species; sulfides
Abstract:
... 808 nm near-infrared (NIR) light-induced biological theranostics is gradually becoming a popular method for cancer treatment. Meanwhile, mild synthetic methods to prepare medicines and gentle treatment conditions for cancer patients are becoming increasingly important to oncotherapy. Herein, tiny AgBiS₂ nanodots were synthesized via a simple method, and for the first time, discovered to produce a ...
DOI:
10.1039/c9bm01077g

28. Ailanthone inhibits cell growth and migration of cisplatin resistant bladder cancer cells through down-regulation of Nrf2, YAP, and c-Myc expression.

Author:
Martina Daga; Stefania Pizzimenti; Chiara Dianzani; Marie Angele Cucci; Roberta Cavalli; Margherita Grattarola; Benedetta Ferrara; Valentina Scariot; Francesco Trotta; Giuseppina Barrera
Source:
Phytomedicine 2019 v.56 pp. 156-164
ISSN:
0944-7113
Subject:
Ailanthus altissima; Western blotting; active ingredients; antibodies; antineoplastic activity; apoptosis; bladder; cell growth; cell lines; cell movement; cisplatin; cortex; essential genes; flow cytometry; gene expression; humans; interphase; neoplasm cells; protein synthesis; staining; therapeutics; tissue repair; toxicity; urinary bladder neoplasms
Abstract:
... Ailanthone (Aila) is a natural active compound isolated from the Ailanthus altissima, which has been shown to possess an “in vitro” growth-inhibitory effect against several cancer cell lines. Advanced bladder cancer is a common disease characterized by a frequent onset of resistance to cisplatin-based therapy. The cisplatin (CDDP) resistance is accompanied by an increase in Nrf2 protein expression ...
DOI:
10.1016/j.phymed.2018.10.034

29. An Alcohol-Soluble Polysaccharide from Atractylodes macrocephala Koidz Induces Apoptosis of Eca-109 cells

Author:
Ying-ying Feng; Hai-yu Ji; Xiao-dan Dong; An-jun Liu
Source:
Carbohydrate polymers 2019 pp. -
ISSN:
0144-8617
Subject:
Atractylodes macrocephala; Fourier transform infrared spectroscopy; Western blotting; antineoplastic activity; apoptosis; arabinose; dyes; esophageal neoplasms; gas chromatography; gel chromatography; glucose; glycosidic linkages; interphase; mitochondria; polysaccharides; rhodamines; staining; therapeutics
Abstract:
... In this study, polysaccharides from Atractylodes macrocephala Koidz (APA) which were soluble in alcohol were prepared, purified, analyzed the structure and investigated the antitumor activity in vitro cell experiment. Results of high-performance gel permeation chromatography (HPGPC), fourier-transform infrared spectroscopy (FT-IR), and gas chromatography (GC) showed that APA was a 2.1KDa neutral h ...
DOI:
10.1016/j.carbpol.2019.115136

30. Alcohol-soluble polysaccharide from Castanea mollissima blume: Preparation, characteristics and antitumor activity

Author:
Xiao-dan Dong; Juan Yu; Ying-ying Feng; Hai-yu Ji; Sha-Sha Yu; An-jun Liu
Source:
Journal of functional foods 2019 v.63 pp. 103563
ISSN:
1756-4646
Subject:
Castanea mollissima; Fourier transform infrared spectroscopy; antineoplastic activity; apoptosis; blood serum; cell cycle; galactose; glucose; glycosidic linkages; immune response; interferon-gamma; interleukin-2; macrophages; mice; natural killer cells; neoplasm cells; polysaccharides; staining; tumor necrosis factor-alpha; uronic acids
Abstract:
... CMBP was an alcohol-soluble polysaccharide extracted from Castanea mollissima blume. Our study aimed to investigate the preliminary structural characteristics and in vivo antitumor activity of CMBP. The contents of total sugar, protein and uronic acid in CMBP was 93.68%, 0.89% and 1.78%, respectively. GC and FTIR results suggested galactose and glucose were detected for CMBP (2.86 × 103 Da), while ...
DOI:
10.1016/j.jff.2019.103563

31. Algae metabolites: from in vitro growth inhibitory effects to promising anticancer activity

Author:
Florence Lefranc; Aikaterini Koutsaviti; Efstathia Ioannou; Alexander Kornienko; Vassilios Roussis; Robert Kiss; David Newman
Source:
Natural product reports 2019 v.36 no.5 pp. 810-841
ISSN:
1460-4752
Subject:
algae; antineoplastic activity; autotrophs; drug therapy; marine environment; metabolites; metastasis; models; neoplasm cells; neoplasms; signal transduction; transporters
Abstract:
... Covering: 1957 to 2017 Algae constitute a heterogeneous group of eukaryotic photosynthetic organisms, mainly found in the marine environment. Algae produce numerous metabolites that help them cope with the harsh conditions of the marine environment. Because of their structural diversity and uniqueness, these molecules have recently gained a lot of interest for the identification of medicinally use ...
DOI:
10.1039/c8np00057c

32. Alkaloids isolated from Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae: Anticancer activity of coccinine and montanine

Author:
M. Masi; S. Van slambrouck; S. Gunawardana; M.J. van Rensburg; P.C. James; J.G. Mochel; P.S. Heliso; A.S. Albalawi; A. Cimmino; W.A.L. van Otterlo; A. Kornienko; I.R. Green; A. Evidente
Source:
South African journal of botany 2019 v.126 pp. 277-281
ISSN:
0254-6299
Subject:
Haemanthus; antineoplastic activity; bulbs; human cell lines; humans; lycorine; metabolites; neoplasm cells
Abstract:
... Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae, was studied for the first time for its alkaloid content. From the acid extract of its bulbs, albomaculine, incartine, coccinine and montanine, belonging to the lycorine-, homolycorine- and isoquinoline-type alkaloids respectively, were isolated. Coccinine was the main metabolite (1.49 g/kg) and to the best of our knowledge H. hu ...
DOI:
10.1016/j.sajb.2019.01.036

33. Allium vegetables for possible future of cancer treatment

Author:
Yahya Asemani; Nasrindokht Zamani; Maryam Bayat; Zahra Amirghofran
Source:
Phytotherapy research 2019 v.33 no.12 pp. 3019-3039
ISSN:
0951-418X
Subject:
Allium; adverse effects; ajoene; antineoplastic activity; antineoplastic agents; antioxidant activity; apoptosis; cell cycle; chives; garlic; health effects assessments; ingredients; leeks; medicinal plants; metastasis; neoplasm cells; neoplasms; quercetin; shallots; signal transduction; sulfur; therapeutics; traditional medicine
Abstract:
... Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, onions, leeks, chives, and shallots. These plants have been exploited in folk medicine because of their beneficial health effects in improving numerou ...
DOI:
10.1002/ptr.6490

34. Ameliorative effects of aqueous extract of Forsythiae suspensa fruits on oxaliplatin-induced neurotoxicity in vitro and in vivo

Author:
Jin-Mu Yi; Sarah Shin; No Soo Kim; Ok-Sun Bang
Source:
BMC complementary and alternative medicine 2019 v.19 no.1 pp. 339
ISSN:
1472-6882
Subject:
Forsythia suspensa; Oriental traditional medicine; adverse effects; alternative medicine; antibodies; antineoplastic activity; antineoplastic agents; colorectal neoplasms; cytotoxicity; dried fruit; drug therapy; fruits; ganglia; herbal medicines; human diseases; immunohistochemistry; liquid chromatography; males; models; neoplasm cells; nerve growth factor; neurites; neuroprotective effect; neurotoxicity; patients; peripheral nervous system diseases; quality of life; staining; viability assays
Abstract:
... BACKGROUND: The dried fruits of Forsythia suspensa has generally been used to clear heat and detoxify in traditional Korean and Chinese medicine. Oxaliplatin is a first-line treatment chemotherapeutic agent for advanced colorectal cancer, but it induces peripheral neuropathy as an adverse side effect affecting the treatment regimen and the patient’s quality of life. The present study was conducted ...
DOI:
10.1186/s12906-019-2761-8
PubMed:
31783843
PubMed Central:
PMC6884752

35. American Ginseng (Panax quinquefolium L.) as a Source of Bioactive Phytochemicals with Pro-Health Properties

Author:
Daria Szczuka; Adriana Nowak; Małgorzata Zakłos-Szyda; Ewa Kochan; Grażyna Szymańska; Ilona Motyl; Janusz Blasiak
Source:
Nutrients 2019 v.11 no.5 pp. -
ISSN:
2072-6643
Subject:
Panax quinquefolius; active ingredients; adipose tissue; animal models; antimicrobial properties; antineoplastic activity; apoptosis; bacteria; cognition; dietary recommendations; fruits; ginsenosides; health effects assessments; heart failure; herbs; hypertrophy; inflammation; insulin resistance; leaves; mice; neoplasm cells; neoplasms; neurons; neuroprotective effect; phytochemicals; rats; reactive oxygen species; roots; stroke; therapeutics; tranquilizers; virulent strains; Asia; North America
Abstract:
... Panax quinquefolium L. (American Ginseng, AG) is an herb characteristic for regions of North America and Asia. Due to its beneficial properties it has been extensively investigated for decades. Nowadays, it is one of the most commonly applied medical herbs worldwide. Active compounds of AG are ginsenosides, saponins of the glycosides group that are abundant in roots, leaves, stem, and fruits of th ...
DOI:
10.3390/nu11051041
PubMed:
31075951
PubMed Central:
PMC6567205

36. Amino modified metal-organic frameworks as pH-responsive nanoplatforms for safe delivery of camptothecin

Author:
Alejandro Cabrera-García; Elisa Checa-Chavarria; Eva Rivero-Buceta; Victoria Moreno; Eduardo Fernández; Pablo Botella
Source:
Journal of colloid and interface science 2019 v.541 pp. 163-174
ISSN:
0021-9797
Subject:
antineoplastic activity; biocompatibility; chemical bonding; coordination polymers; cytotoxicity; drug carriers; drugs; in vitro studies; iron; pH; porous media
Abstract:
... MIL-100(Fe) and MIL-101(Fe) metal-organic frameworks (MOFs) are excellent vehicles for drug delivery systems (DDSs) due to their high biocompatibility and stability in physiological fluids, as well as their pore diameter in the mesoporous range. Although they are appropriate for the internal diffusion of 20-(S)-camptothecin (CPT), a strongly cytotoxic molecule with excellent antitumor activity, no ...
DOI:
10.1016/j.jcis.2019.01.042

37. Amphidinol 22, a New Cytotoxic and Antifungal Amphidinol from the Dinoflagellate Amphidinium carterae

Author:
Kevin A. Martínez; Chiara Lauritano; Dana Druka; Giovanna Romano; Teresa Grohmann; Marcel Jaspars; Jesús Martín; Caridad Díaz; Bastien Cautain; Mercedes de la Cruz; Adrianna Ianora; Fernando Reyes
Source:
Marine drugs 2019 v.17 no.7 pp. -
ISSN:
1660-3397
Subject:
Amphidinium; Aspergillus fumigatus; Escherichia coli; Gram-negative bacteria; Gram-positive bacteria; Klebsiella pneumoniae; Mycobacterium tuberculosis; adenocarcinoma; antifungal properties; antineoplastic activity; bioactive compounds; biodiversity; breast neoplasms; breasts; cell lines; cytotoxicity; fractionation; fungi; habitats; hepatoma; humans; lungs; mass spectrometry; melanoma; methicillin-resistant Staphylococcus aureus; neoplasm cells; nuclear magnetic resonance spectroscopy; pancreas; physicochemical properties; skin (animal)
Abstract:
... Due to the unique biodiversity and the physical-chemical properties of their environment, marine microorganisms have evolved defense and signaling compounds that often have no equivalent in terrestrial habitats. The aim of this study was to screen extracts of the dinoflagellate Amphidinium carterae for possible bioactivities (i.e., anticancer, anti-inflammatory, anti-diabetes, antibacterial and an ...
DOI:
10.3390/md17070385
PubMed:
31252576
PubMed Central:
PMC6669446

38. Amphiphilic Gemini Iridium(III) Complex as a Mitochondria-Targeted Theranostic Agent for Tumor Imaging and Photodynamic Therapy

Author:
Sili Yi; Zhen Lu; Jin Zhang; Jun Wang; Zenghong Xie; Linxi Hou
Source:
ACS applied materials & interfaces 2019 v.11 no.17 pp. 15276-15289
ISSN:
1944-8252
Subject:
antineoplastic activity; diagnostic techniques; emissions factor; human cell lines; image analysis; in vivo studies; iridium; ligands; mitochondria; neoplasm cells; neoplasms; photochemotherapy; photostability; phototoxicity; quaternary ammonium compounds; singlet oxygen; spectroscopy; water solubility
Abstract:
... Clinical diagnostics and therapeutics of tumors are significantly benefitted by the development of multifunctional theranostic agents, which integrate tumor targeting, imaging, and therapeutics. However, the integration of imaging and therapy functionalities to a unimolecular framework remains a great challenge. Herein, a family of amphiphilic gemini iridium(III) complexes (GIC), Ir1–Ir6, are synt ...
DOI:
10.1021/acsami.9b01205

39. Analyses of the possible anti-tumor effect of yokukansan

Author:
Cheolsun Han; Miho Kawata; Yusuke Hamada; Takashige Kondo; Junna Wada; Katsunori Asano; Hitoshi Makabe; Katsuhide Igarashi; Naoko Kuzumaki; Michiko Narita; Hiroyuki Kobayashi; Minoru Narita
Source:
Natural medicines 2019 v.73 no.3 pp. 468-479
ISSN:
1340-3443
Subject:
analgesic effect; antineoplastic activity; blood serum; epidermal growth factor receptors; hypothalamus; in vitro studies; intestinal microorganisms; lung neoplasms; medicine; mice; microRNA; microarray technology; neoplasm progression; pellets; signal transduction; tranquilizers
Abstract:
... The Kampo medicine yokukansan (YKS) has a wide variety of properties such as anxiolytic, anti-inflammatory and analgesic effects, and is also thought to regulate tumor suppression. In this study, we investigated the anti-tumor effect of YKS. We used Lewis lung carcinoma (LLC)-bearing mice that were fed food pellets containing YKS and then performed a fecal microbiota analysis, a microarray analysi ...
DOI:
10.1007/s11418-019-01283-x

40. Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from Foeniculum vulgare from Hamedan, Iran

Author:
Maryam Akhbari; Reza Kord; Saeedeh Jafari Nodooshan; Sepideh Hamedi
Source:
Natural product research 2019 v.33 no.11 pp. 1629-1632
ISSN:
1478-6427
Subject:
Artemia; Escherichia coli; Foeniculum vulgare; Pseudomonas aeruginosa; Shigella dysenteriae; antibacterial properties; antineoplastic activity; antineoplastic agents; breast neoplasms; carcinoma; cell lines; death; essential oils; gas chromatography-mass spectrometry; humans; inhibitory concentration 50; lethal concentration 50; limonene; methyl chavicol; seed oils; seeds; toxicity; Iran
Abstract:
... In this study, biological properties of the essential oil isolated from seeds of Foeniculum vulgare (F. vulgare) were evaluated. GC-MS analysis revealed Trans-Anethole (80.63%), L-Fenchone (11.57%), Estragole (3.67%) and Limonene (2.68%) were the major compounds of the essential oil. Antibacterial activity of the essential oil against nine Gram-positive and Gram-negative strains was studied using ...
DOI:
10.1080/14786419.2017.1423310

41. Analytical methods to access the chemical composition of an Euphorbia tirucalli anticancer latex from traditional Brazilian medicine

Author:
Larissa Silva de Souza; Letícia C. Puziol; Cristina Luz Tosta; Milena L.F. Bittencourt; Juliana Santa Ardisson; Rodrigo Rezende Kitagawa; Paulo Roberto Filgueiras; Ricardo Machado Kuster
Source:
Journal of ethnopharmacology 2019 v.237 pp. 255-265
ISSN:
0378-8741
Subject:
Euphorbia tirucalli; adenocarcinoma; antineoplastic activity; atmospheric pressure; chemical composition; chemical constituents of plants; commercialization; cytotoxicity; diterpenoids; esters; gas chromatography-mass spectrometry; hexane; immunomodulators; inhibitory concentration 50; interleukin-6; ionization; latex; linoleic acid; macrophages; methanol; methylene chloride; monitoring; myristic acid; neoplasm cells; nitric oxide; nuclear magnetic resonance spectroscopy; oleic acid; palmitic acid; stearic acid; steroids; tandem mass spectrometry; traditional medicine; triterpenoids; tumor necrosis factor-alpha
Abstract:
... Euphorbia tirucalli L. is widely used by Brazilian folk medicine, mainly for its anticancer activity. However, its commercialization was banned by The Brazilian National Sanitary Surveillance Agency (ANVISA) due to the presence of some compounds considered toxic, such as the diterpene esters.Aim of the study: Chemical and biological analyses were performed with the Brazilian Euphorbia tirucalli la ...
DOI:
10.1016/j.jep.2019.03.041

42. Anchusa azurea Mill. (Boraginaceae) aerial parts methanol extract interfering with cytoskeleton organization induces programmed cancer cells death

Author:
Jessica CeramellaThese authors have contributed equally to the manuscript.; Monica Rosa Loizzo; Domenico Iacopetta; Marco Bonesi; Vincenzo Sicari; Teresa Maria Pellicanò; Carmela Saturnino; Aurélie Malzert-Fréon; Rosa TundisJoint senior authors.; Maria Stefania Sinicropi
Source:
Food & function 2019 v.10 no.7 pp. 4280-4290
ISSN:
2042-650X
Subject:
2,2-diphenyl-1-picrylhydrazyl; Anchusa azurea; aerial parts; antineoplastic activity; antioxidant activity; beta-carotene; bleaching; caffeic acid; caspase-3; catechin; cell death; cell lines; chemical composition; chlorogenic acid; cytoskeleton; death; high performance liquid chromatography; inhibitory concentration 50; menadione; methanol; mice; neoplasm cells; neoplasms; oxidative stress; toxicity
Abstract:
... The present study aimed to determine the chemical composition, antioxidant effects and antitumor properties of a methanol extract of Anchusa azurea Mill. (Boraginaceae) aerial parts against four tumour cell lines (MCF-7, MDA-MB-231, RKO, and R₂C). The antioxidant effects were assessed by using β-carotene bleaching, 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picryl ...
DOI:
10.1039/c9fo00582j

43. Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin

Author:
Luan He; Yong Zhang; Naixin Kang; Yaner Wang; Ziyu Zhang; Zhengxia Zha; Shilin Yang; Qiongming Xu; Yanli Liu
Source:
Phytomedicine 2019 v.56 pp. 136-146
ISSN:
0944-7113
Subject:
Anemone chinensis; Western blotting; adverse effects; anti-inflammatory activity; antineoplastic activity; antioxidant activity; apoptosis; blood; body weight; catalase; cell viability; cisplatin; creatinine; drug therapy; flow cytometry; glutathione; histopathology; in vivo studies; kidneys; mice; models; neoplasms; nephrotoxicity; protective effect; reactive oxygen species; renal failure; saponins; superoxide dismutase; urea nitrogen
Abstract:
... Cisplatin is a highly effective chemotherapeutic agent commonly used in the treatment of a wide variety of malignancies. However, its clinical usage is severely limited by its serious side effects, especially nephrotoxicity. Anemoside B4, is a major saponins, rich in root of Pulsatilla chinensis (Bunge), has anti-inflammation in vitro. However, the antioxidant or anti-inflammatory effects of anemo ...
DOI:
10.1016/j.phymed.2018.10.035

44. Angelica sinensis polysaccharide nanoparticles as a targeted drug delivery system for enhanced therapy of liver cancer

Author:
Yu Zhang; Zheng Cui; Hao Mei; Jingya Xu; Tao Zhou; Fang Cheng; Kaiping Wang
Source:
Carbohydrate polymers 2019 v.219 pp. 143-154
ISSN:
0144-8617
Subject:
Angelica sinensis; antineoplastic activity; biocompatibility; deoxycholic acid; dextran; doxorubicin; drug carriers; endocytosis; hydrophobicity; image analysis; liver neoplasms; nanoparticles; pH; particle size; solubility
Abstract:
... In recent years, the utilization of polysaccharides as targeted drug carriers has attracted considerable attention. Herein, Angelica sinensis polysaccharide (ASP), a plant polysaccharide with good biocompatibility, excellent aqueous solubility and intrinsic liver-targeted capability, was modified with hydrophobic group (deoxycholic acid) to fabricate amphiphilic conjugate (ASP-DOCA). Self-assemble ...
DOI:
10.1016/j.carbpol.2019.04.041

45. Anion Transporters Based on Noncovalent Balance including Anion−π, Hydrogen, and Halogen Bonding

Author:
Wen-Long Huang; Xu-Dong Wang; Sen Li; Rui Zhang; Yu-Fei Ao; Jun Tang; Qi-Qiang Wang; De-Xian Wang
Source:
Journal of organic chemistry 2019 v.84 no.14 pp. 8859-8869
ISSN:
1520-6904
Subject:
antineoplastic activity; aromatic hydrocarbons; bromides; cell viability; chemical reactions; chemical structure; density functional theory; fluorescence; gallic acid; halogens; hydrogen; inhibitory concentration 50; median effective concentration; nuclear magnetic resonance spectroscopy; organic chemistry; potassium chloride; transporters; triazines
Abstract:
... Anion transmembrane transport mediated by novel noncovalent interactions is of central interest in supramolecular chemistry. In this work, a series of oxacalix[2]arene[2]triazine-derived transporters 1 and 2 bearing anion−π-, hydrogen-, and halogen-bonding sites in rational proximity were designed and synthesized by a one-pot strategy starting from gallic acid ester derivatives and mono- or di-hal ...
DOI:
10.1021/acs.joc.9b00561

46. Antarctic Krill (Euphausia superba) Oil: A Comprehensive Review of Chemical Composition, Extraction Technologies, Health Benefits, and Current Applications

Author:
Dan Xie; Mengyue Gong; Wei Wei; Jun Jin; Xiaosan Wang; Xingguo Wang; Qingzhe Jin
Source:
Comprehensive reviews in food science and food safety 2019 v.18 no.2 pp. 514-534
ISSN:
1541-4337
Subject:
Euphausia superba; anti-inflammatory activity; antineoplastic activity; astaxanthin; cardiovascular diseases; dietary supplements; docosahexaenoic acid; eicosapentaenoic acid; flavonoids; ingredients; krill; minerals; neuroprotective effect; novel foods; oils; phospholipids; solvents; sterols; tocopherols; vitamin A; women's health
Abstract:
... Antarctic krill (Euphausia superba) oil has been receiving increasing attention due to its nutritional and functional potentials. However, its application as a novel food ingredient has not yet been fully explored. This review summarizes the chemical composition, extraction technologies, potential health benefits, and current applications of krill oil, with the aim of providing suggestions for its ...
DOI:
10.1111/1541-4337.12427

47. Anthocyanins/anthocyanidins and colorectal cancer: What is behind the scenes?

Author:
Luís Fernando de Sousa Moraes; Xiaofei Sun; Maria do Carmo Gouveia Peluzio; Mei-Jun Zhu
Source:
Critical reviews in food science and nutrition 2019 v.59 no.1 pp. 59-71
ISSN:
1549-7852
Subject:
AMP-activated protein kinase; anthocyanidins; anthocyanins; anticarcinogenic activity; antineoplastic activity; antioxidants; apoptosis; carcinogenesis; cell proliferation; chemoprevention; colorectal neoplasms; death; epithelial cells; intestines; mammals; metalloproteinases; metastasis; rapamycin; transcription factor NF-kappa B
Abstract:
... Colorectal cancer (CRC) is one of the most common cause of cancer death. Phytochemicals, especially anthocyanins/anthocyanidins (A/A), have gathered attention of the scientific community owing to their anti-inflammatory, antioxidant, and cancer-inhibitory properties. In this review, we discussed the possible mechanisms whereby A/A exhibit intestinal anticarcinogenic characteristics. Anthocyanins/a ...
DOI:
10.1080/10408398.2017.1357533

48. Anti-Aging Effect of Agar Oligosaccharide on Male Drosophila melanogaster and Its Preliminary Mechanism

Author:
Chao Ma; Kun Yang; Yifan Wang; Xianjun Dai
Source:
Marine drugs 2019 v.17 no.11 pp. -
ISSN:
1660-3397
Subject:
Drosophila melanogaster; agar; anti-aging properties; antineoplastic activity; antioxidant activity; catalase; gene expression regulation; genes; immunity; immunomodulators; insect reproduction; intestinal microorganisms; intestines; longevity; male fertility; males; malondialdehyde; microbial communities; midgut; oligosaccharides; prebiotics; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; ribosomal DNA; sequence analysis; vigor
Abstract:
... Agar oligosaccharide (AOS) is a marine prebiotic with apparent anti-inflammatory, antioxidant and anti-tumor effects. During this study, different doses of AOS are added to a basal diet to evaluate its effects on the lifespan, motor vigor and reproduction of male Drosophila melanogaster. Additionally, the activities of Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and catalase (CAT) and the malondialdehy ...
DOI:
10.3390/md17110632
PubMed:
31698828
PubMed Central:
PMC6891751

49. The Anti-Cancer Effect of Mangifera indica L. Peel Extract is Associated to γH2AX-mediated Apoptosis in Colon Cancer Cells

Author:
Marianna Lauricella; Valentina Lo Galbo; Cesare Cernigliaro; Antonella Maggio; Antonio Palumbo Piccionello; Giuseppe Calvaruso; Daniela Carlisi; Sonia Emanuele; Michela Giuliano; Antonella D’Anneo
Source:
Antioxidants 2019 v.8 no.10 pp. -
ISSN:
2076-3921
Subject:
DNA damage; Mangifera indica; antineoplastic activity; apoptosis; cell lines; cell viability; colorectal neoplasms; fibroblasts; fruit pulp; gene expression regulation; high performance liquid chromatography; histones; humans; mango peels; mangoes; mass spectrometry; mitogen-activated protein kinase; models; mutagens; neoplasm cells; phenolic compounds; phosphorylation; reactive oxygen species; signal transduction; superoxide dismutase
Abstract:
... Ethanolic extracts from Mangifera indica L. have been proved to possess anti-tumor properties in many cancer systems. However, although most effects have been demonstrated with fruit pulp extract, the underlying molecular mechanisms of mango peel are still unclear. This study was designed to explore the effects of mango peel extract (MPE) on colon cancer cell lines. MPE affected cell viability and ...
DOI:
10.3390/antiox8100422
PubMed:
31546694
PubMed Central:
PMC6826946

50. Anti-Colorectal Cancer Effects of Probiotic-Derived p8 Protein

Author:
Byung Chull An; Sunwoong Hong; Ho Jin Park; Bong-Kyu Kim; Jun Young Ahn; Yongku Ryu; Jae Hyung An; Myung Jun Chung
Source:
Genes 2019 v.10 no.8 pp. -
ISSN:
2073-4425
Subject:
antineoplastic activity; cell cycle checkpoints; cell lines; colorectal neoplasms; cytosol; endocytosis; gene therapy; in vitro studies; neoplasm cells; signal transduction; toxicity
Abstract:
... Recently, we reported a novel therapeutic probiotic-derived protein, p8, which has anti-colorectal cancer (anti-CRC) properties. In vitro experiments using a CRC cell line (DLD-1), anti-proliferation activity (about 20%) did not improve after increasing the dose of recombinant-p8 (r-p8) to >10 μM. Here, we show that this was due to the low penetrative efficiency of r-p8 exogenous treatment. Fur ...
DOI:
10.3390/genes10080624
PubMed:
31430963
PubMed Central:
PMC6723380