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You searched for: Publication Year 2019 Remove constraint Publication Year: 2019 Subject aspirin Remove constraint Subject: aspirin Subject cardiovascular diseases Remove constraint Subject: cardiovascular diseases Subject term cardiovascular diseases Remove constraint Subject term: cardiovascular diseases
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1. Activation of catalase via co-administration of aspirin and pioglitazone: Experimental and MLSD simulation approaches

Author:
Yunes Panahi; Reza Yekta; Gholamreza Dehghan; Samaneh Rashtbari; Nematollah Jonaidi Jafari; Ali A. Moosavi-Movahedi
Source:
Biochimie 2019 v.156 pp. 100-108
ISSN:
0300-9084
Subject:
aspirin; binding capacity; blood glucose; cardiovascular diseases; catalase; circular dichroism spectroscopy; dialysis; enzyme activity; ligands; liver; patients
Abstract:
... Aspirin (ASP) and pioglitazone (PGL) are the most common drugs that are widely used by diabetic patients to control the blood sugar and hinder cardiovascular diseases. The interaction between PGL and ASP is one of the important medical issues to clarify the safety of co-administration of these drugs. In the present study, the effect of co-administered ASP with PGL was investigated on the structure ...
DOI:
10.1016/j.biochi.2018.10.007

2. A high glucose level is associated with decreased aspirin-mediated acetylation of platelet cyclooxygenase (COX)-1 at serine 529: A pilot study

Author:
Francesco Finamore; Jean-Luc Reny; Sarah Malacarne; Pierre Fontana; Jean-Charles Sanchez
Source:
Journal of proteomics 2019 v.192 pp. 258-266
ISSN:
1874-3919
Subject:
acetylation; aspirin; blood platelets; cardiovascular diseases; diabetes; glucose; glycation; hyperglycemia; mass spectrometry; patients; prostaglandin synthase; proteins; risk factors; serine
Abstract:
... Diabetes is a major risk factor for cardiovascular diseases. Although aspirin is considered a cornerstone of the prevention and treatment of atherothrombotic-related ischemic events, this antiplatelet drug appears to be less effective in patients with poorly controlled diabetes. It has been suggested that the glycation of platelet proteins plays a pivotal role in poor responsiveness to aspirin. Ho ...
DOI:
10.1016/j.jprot.2018.09.007