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You searched for: Publication Year 2019 Remove constraint Publication Year: 2019 Subject cerebrospinal fluid Remove constraint Subject: cerebrospinal fluid Subject term animal injuries Remove constraint Subject term: animal injuries
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1. Single-step functionalization of poly-catecholamine nanofilms for ultra-sensitive immunosensing of ubiquitin carboxyl terminal hydrolase-L1 (UCHL-1) in spinal cord injury

Author:
Sultan Khetani; Vinayaraj Ozhukil Kollath; Erin Eastick; Chantel Debert; Arindom Sen; Kunal Karan; Amir Sanati-Nezhad
Source:
Biosensors & bioelectronics 2019 v.145 pp. 111715
ISSN:
0956-5663
Subject:
animal injuries; antibodies; aqueous solutions; biomarkers; blood serum; brain; cerebrospinal fluid; dopamine; electrodes; gamma-aminobutyric acid; glutamic acid; graphene; immunosensors; moieties; nanosheets; neurotransmitters; norepinephrine; patients; phosphates; polymers; spinal cord; ubiquitin; ubiquitinyl hydrolase 1
Abstract:
... Rapid, selective, and ultra-sensitive detection of brain and spinal cord injury markers in bodily fluids is an unmet clinical need. In this work, Polycatecholamine as a rich source of amine moieties was used for single-step fabrication of ultrasensitive immunosensors for the detection of Ubiquitin carboxyl-terminal hydrolase (UCHL-1) biomarker of brain and spinal cord injuries and address the clin ...
DOI:
10.1016/j.bios.2019.111715

2. CD8 T cell-derived perforin aggravates secondary spinal cord injury through destroying the blood-spinal cord barrier

Author:
Zhaoxiang Liu; Hua Zhang; Hong Xia; Baocheng Wang; Renwen Zhang; Qun Zeng; Lingzhi Guo; Kui Shen; BaTa Wang; Yanheng Zhong; Zhizhong Li; Guodong Sun
Source:
Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
Abstract:
... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
DOI:
10.1016/j.bbrc.2019.03.002