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1. Heat preconditioning and aspirin treatment attenuate hepatic carbohydrate-related disturbances in diabetic rats

Author:
Mirsada Dervisevic; Maja Dimitrovska; Natasa Cipanovska; Suzana Dinevska- Kjovkarovska; Biljana Miova
Source:
Journal of thermal biology 2019 v.79 pp. 190-198
ISSN:
0306-4565
Subject:
animal disease models; aspirin; blood; diabetes; enzyme activity; enzymes; glucose; glycemic effect; glycogen; heat; liver; metabolism; rats
Abstract:
... Heat preconditioning (HP) is a powerful adaptive and protective phenomenon and induces moderation of diabetic alterations in glycogen metabolism of rats. Aspirin (acetylsalicylic acid, ASA), as a multifunctional drug has also been reported to exert hypoglycemic effects in the treatment of diabetes. We estimated the effect of HP (45 min/41 ± 0.5 °C/24 h recovery) and single dose aspirin (100 mg/kg ...
DOI:
10.1016/j.jtherbio.2018.12.005

2. A high glucose level is associated with decreased aspirin-mediated acetylation of platelet cyclooxygenase (COX)-1 at serine 529: A pilot study

Author:
Francesco Finamore; Jean-Luc Reny; Sarah Malacarne; Pierre Fontana; Jean-Charles Sanchez
Source:
Journal of proteomics 2019 v.192 pp. 258-266
ISSN:
1874-3919
Subject:
acetylation; aspirin; blood platelets; cardiovascular diseases; diabetes; glucose; glycation; hyperglycemia; mass spectrometry; patients; prostaglandin synthase; proteins; risk factors; serine
Abstract:
... Diabetes is a major risk factor for cardiovascular diseases. Although aspirin is considered a cornerstone of the prevention and treatment of atherothrombotic-related ischemic events, this antiplatelet drug appears to be less effective in patients with poorly controlled diabetes. It has been suggested that the glycation of platelet proteins plays a pivotal role in poor responsiveness to aspirin. Ho ...
DOI:
10.1016/j.jprot.2018.09.007