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You searched for: Publication Year 2019 Remove constraint Publication Year: 2019 Subject term Danio rerio Remove constraint Subject term: Danio rerio
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1. 1,3‐1‐6 ß‐glucans enhance tissue regeneration in zebrafish (Danio rerio): Potential advantages for aquaculture applications

Author:
Baldassare Fronte; Cheol‐Hee Kim; Marco Bagliacca; Lucia Casini; Mahanama De Zoysa
Source:
Aquaculture research 2019 v.50 no.11 pp. 3163-3170
ISSN:
1355-557X
Subject:
Danio rerio; amputation; animal models; aquaculture; beta-glucans; diet; fish; gills; macrophages; oral administration; secondary infection; stocking rate; tissue repair; tissues
Abstract:
... High aquacultural rearing density and handling of fish may frequently result in skin or gills wounds, thereby facilitating the onset of secondary infections. The capacity of the zebrafish to regenerate tissues, as well as fins and other organs, makes it an ideal animal model for studying the mechanisms of tissue regeneration. Since macrophages are involved in tissue regeneration, a diet including ...
DOI:
10.1111/are.14270

2. 2,4-Dichlorophenoxyacetic acid containing herbicide impairs essential visually guided behaviors of larval fish

Author:
Gavin K. Dehnert; William H. Karasov; Marc A. Wolman
Source:
Aquatic toxicology 2019 v.209 pp. 1-12
ISSN:
0166-445X
Subject:
2,4-D; Danio rerio; Perca flavescens; active ingredients; auxins; cell death; ecosystems; fish communities; fish larvae; freshwater fish; invasive species; nervous system; neural networks; nontarget organisms; plants (botany); spawning; toxicity; vision; xenobiotics
Abstract:
... Aquatic herbicides are used worldwide to eradicate nuisance and invasive plants despite limited knowledge of their toxicity to non-target organisms. 2,4-Dichlorophenoxyacetic acid (2,4-D) is a common active ingredient in commercial herbicide formulations, which triggers plant cell death by mimicking the plant-specific hormone auxin. Application practices of 2,4-D commercial herbicides typically co ...
DOI:
10.1016/j.aquatox.2019.01.015

3. A PET and ESIPT based fluorescent probe for the imaging of hydrogen sulfide (H₂S) in live cells and zebrafish

Author:
Yaru Lu; Baoli Dong; Wenhui Song; Xiuqi Kong; Abdul Hadi Mehmood; Weiying Lin
Source:
Analytical methods 2019 v.11 no.26 pp. 3301-3306
ISSN:
1759-9679
Subject:
Danio rerio; analytical methods; fluorescence; fluorescent dyes; hydrogen sulfide; image analysis; rapid methods; thiolysis
Abstract:
... H₂S is an important signaling molecule in living systems and participates in a series of physiological and pathological processes. In situ and rapid detection of H₂S levels in living systems is of great importance to the in-depth study of its physiological and pathological roles. Herein, we present a new fluorescent probe (DFAN) for the detection of H₂S in live cells and zebrafish. The probe DFAN ...
DOI:
10.1039/c9ay00927b

4. A chromenoquinoline-based two-photon fluorescent probe for the highly specific and fast visualization of sulfur dioxide derivatives in living cells and zebrafish

Author:
Fangyuan Cai; Bo Hou; Shuping Zhang; Hua Chen; Shichen Ji; Xing-can Shen; Hong Liang
Source:
Journal of materials chemistry B 2019 v.7 no.15 pp. 2493-2498
ISSN:
2050-7518
Subject:
Danio rerio; bisulfites; fluorescent dyes; image analysis; moieties; monitoring; sulfites; sulfur dioxide
Abstract:
... Sulfur dioxide (SO₂) derivatives play critical roles in various biological processes. Therefore, effective methods for monitoring SO₂ are of vital importance in bisulfite/sulfite biology. In this study, a two-photon (TP) imaging probe (CQ-SO₂) for detecting SO₂ derivatives was designed and constructed, based on the chromenoquinoline (CQ) fluorophore and a β-chlorovinyl aldehyde sensing moiety. The ...
DOI:
10.1039/c9tb00179d

5. A new evolutionary model for the vertebrate actin family including two novel groups

Author:
Laura Witjes; Marleen Van Troys; Joël Vandekerckhove; Klaas Vandepoele; Christophe Ampe
Source:
Molecular phylogenetics and evolution 2019 pp. -
ISSN:
1055-7903
Subject:
Anolis carolinensis; Danio rerio; Gallus gallus; Mus musculus; Xenopus tropicalis; actin; chickens; databases; disease models; genes; lizards; mice; muscles; smooth muscle; surveys
Abstract:
... Database surveys in the vertebrate model organisms: chicken (Gallus gallus), western clawed frog (Xenopus tropicalis), anole lizard (Anolis carolinensis) and zebrafish (Danio rerio) indicate that in some of these species the number of actin paralogues differs from the well-established six paralogues in mouse (Mus musculus). To investigate differential functions of actins and for establishing disea ...
DOI:
10.1016/j.ympev.2019.106632

6. A novel CC chemokine ligand 2 like gene from ayu Plecoglossus altivelis is involved in the innate immune response against to Vibrio anguillarum

Author:
Li Yu; Chang-Hong Li; Jiong Chen
Source:
Fish & shellfish immunology 2019 v.87 pp. 886-896
ISSN:
1050-4648
Subject:
Astyanax mexicanus; Danio rerio; Plecoglossus altivelis; Vibrio anguillarum; antibodies; chemokine CCL2; chemotaxis; complementary DNA; fish; gene expression; genes; immune response; intraperitoneal injection; kidneys; ligands; liver; macrophages; messenger RNA; microbial load; monocytes; neutrophils; nucleotide sequences; phagocytosis; respiratory burst; sequence analysis; spleen; tissues
Abstract:
... Chemokine (CC motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein 1 (MCP-1), is one of the key chemokines that regulate migration and infiltration of monocytes/macrophages (MO/MФ) in mammals. However, the functional repertoire of fish CCL2 remains unclear. Here, we identified a cDNA sequence encoding a novel CCL2-like protein (PaCCL2L) in ayu, Plecoglossus altivelis. Sequence an ...
DOI:
10.1016/j.fsi.2019.02.019

7. A novel highly selective fluorescent probe for imaging of cysteine both in living cells and zebrafish

Author:
Li Wang; Mingguang Ren; Zihong Li; Lixuan Dai; Weiying Lin
Source:
Analytical methods 2019 v.11 no.34 pp. 4323-4327
ISSN:
1759-9679
Subject:
Danio rerio; analytical methods; bioimaging; cysteine; fluorescence; fluorescent dyes
Abstract:
... A novel fluorescent probe (PI-Cys) was developed for imaging cysteine both in living cells and zebrafish. The probe has a high selectivity, high fluorescence quantum yield and large turn-on signal. In addition, bioimaging results suggest that it can be used as an endogenous Cys probe and can even detect cysteine in zebrafish. ...
DOI:
10.1039/c9ay01167f

8. A pilot study to elucidate effects of artificial selection by size on the zebrafish (Danio rerio) fast skeletal muscle transcriptome

Author:
P. Harish; E.A. Mareco; D. Garcia de la serrana
Source:
Comparative biochemistry and physiology 2019 v.233 pp. 65-73
ISSN:
1095-6433
Subject:
Danio rerio; animal growth; artificial selection; body length; fish; gene expression; genes; genetic factors; homeostasis; models; muscle development; muscle fibers; muscles; proteasome endopeptidase complex; sarcomeres; single nucleotide polymorphism; skeletal muscle; stress response; transcriptome
Abstract:
... Fish size is a complex trait determined by the interaction of environmental and genetic factors. While evidence exists that fish final length and size are partially determined by muscle fibre structure. However, the molecular basis behind final body size and muscle fibre composition remains yet to be fully understood. Here we use the fish model zebrafish (Danio rerio) to explore the molecular mech ...
DOI:
10.1016/j.cbpa.2019.03.021

9. A potential probiotic Chromobacterium aquaticum with bacteriocin-like activity enhances the expression of indicator genes associated with nutrient metabolism, growth performance and innate immunity against pathogen infections in zebrafish (Danio rerio)

Author:
Che-Chun Yi; Chun-Hung Liu; Kuo-Pin Chuang; Yi-Ting Chang; Shao-Yang Hu
Source:
Fish & shellfish immunology 2019 v.93 pp. 124-134
ISSN:
1050-4648
Subject:
Aeromonas hydrophila; Chromobacterium; Danio rerio; Streptococcus iniae; antibacterial properties; bacterial infections; carbohydrates; complement; disease control; extracellular enzymes; feed supplements; fish; fish diseases; gene expression; genes; glucokinase; glucose-6-phosphatase; growth performance; hexokinase; innate immunity; insulin-like growth factor I; interleukin-10; interleukin-1beta; interleukin-21; interleukin-6; lakes; lysozyme; messenger RNA; metabolism; models; nucleotide sequences; pH; plant pathogens; probiotics; proteinases; pyruvate kinase; ribosomal DNA; sequence analysis; somatotropin receptors; survival rate; transcription factor NF-kappa B; tumor necrosis factor-alpha; xylanases
Abstract:
... The use of probiotics as alternatives to antibiotics for disease control is a relatively eco-friendly approach in aquaculture; hence, studies isolating and assessing the benefit of potential probiotics to fish farming are common. The zebrafish is an excellent model system for validating beneficial functions of potential probiotics before their practical application in aquaculture. Here, a potentia ...
DOI:
10.1016/j.fsi.2019.07.042

10. A ratiometric fluorescent probe for sensitive determination of the important glycopeptide antibiotic vancomycin

Author:
Tao Deng; Shiyou Hu; Liang Zhao; Shengjun Wu; Wei Liu; Tongkai Chen; Tingdan Fu; He Wang; Huifang Shi; Xin-an Huang; Fang Liu
Source:
Analytical and bioanalytical chemistry 2019 v.411 no.30 pp. 8103-8111
ISSN:
1618-2642
Subject:
Danio rerio; blood serum; coumarin; detection limit; fluorescein; fluorescence; glycopeptides; humans; image analysis; urine; vancomycin
Abstract:
... A novel sensitive and selective probe for the important antibiotic vancomycin (Van) has been synthesized by integrating a coumarin and a fluorescein as dual fluorescence reporters and a Van binding peptide D-Ala-D-Ala. Only weak green fluorescence was initially observed, which was mostly attributed to fluorescence self-quenching induced by fluorophore stacking. Upon the binding of Van with the D-A ...
DOI:
10.1007/s00216-019-02190-6

11. A ratiometric two-photon fluorescent probe for the rapid detection of HClO in living systems

Author:
Li Wang; Mingguang Ren; Zihong Li; Lixuan Dai; Weiying Lin
Source:
Analytical methods 2019 v.11 no.12 pp. 1580-1584
ISSN:
1759-9679
Subject:
Danio rerio; analytical methods; fluorescence; fluorescent dyes; image analysis; rapid methods
Abstract:
... We have developed a ratiometric two-photon fluorescent probe: CR-HA. The CR-HA probe could be used for the determination of hypochlorous acid (HClO) in living systems. The result of fluorescence imaging showed that it could be used as a probe to image exogenous/endogenous HClO in living cells, and to detect HClO in living tissue and zebrafish. ...
DOI:
10.1039/c9ay00205g

12. A state-of-the-art review of surrogate propagation in fish

Author:
Rie Goto; Taiju Saito
Source:
Theriogenology 2019 v.133 pp. 216-227
ISSN:
0093-691X
Subject:
Danio rerio; Oryzias latipes; aquaculture; cell transplantation; chimerism; endangered species; fish; gametogenesis; germ cells; hosts; models; seedling production
Abstract:
... Surrogate propagation is a systematic approach to producing donor-derived gametes using germline chimeras. In fish, the use of germline chimeras to study the development of germ cells was first conducted in the 1990s in the model fish species medaka (Oryzias latipes) and zebrafish (Danio rerio). More recently, surrogate propagation has been actively investigated as a means of efficient gamete prod ...
DOI:
10.1016/j.theriogenology.2019.03.032

13. Accumulation of different shapes of microplastics initiates intestinal injury and gut microbiota dysbiosis in the gut of zebrafish

Author:
Ruxia Qiao; Yongfeng Deng; Shenghu Zhang; Marina Borri Wolosker; Qiande Zhu; Hongqiang Ren; Yan Zhang
Source:
Chemosphere 2019 v.236 pp. 124334
ISSN:
0045-6535
Subject:
Danio rerio; bacteria; bioaccumulation; dysbiosis; fish; health effects assessments; inflammation; intestinal microorganisms; intestines; metabolism; microplastics; permeability; toxicity
Abstract:
... Different shapes of microplastics are widely detected in the environment and organisms and most of them remain in the gut. However, the influences of shapes on the bioaccumulation and toxicity of microplastics in the gut are largely unknown. Three shapes (bead, fragment, and fiber) of microplastics of comparable size in one dimension were prepared to exposure to zebrafish. The accumulation and tox ...
DOI:
10.1016/j.chemosphere.2019.07.065

14. Acetaminophen Removal from Water by Microalgae and Effluent Toxicity Assessment by the Zebrafish Embryo Bioassay

Author:
Carla Escapa; Ricardo N. Coimbra; Teresa Neuparth; Tiago Torres; Miguel M. Santos; Marta Otero
Source:
Water 2019 v.11 no.9 pp. -
ISSN:
2073-4441
Subject:
Chlorella sorokiniana; Chlorella vulgaris; Danio rerio; Scenedesmus obliquus; acetaminophen; bioassays; biodegradation; effluents; embryo (animal); microalgae; toxicity; water treatment
Abstract:
... In this work, zebrafish embryo bioassays were performed to assess the efficiency of microalgae in the removal of acetaminophen from water. Chlorella sorokiniana (CS), Chlorella vulgaris (CV) and Scenedesmus obliquus (SO) were the strains used for water treatment. Toxic effects on zebrafish embryo caused by effluents from microalgae treatment were compared with those observed under exposure to expe ...
DOI:
10.3390/w11091929

15. Acridone Derivate Simultaneously Featuring Multiple Functions and Its Applications

Author:
Yaokun Xia; Wenhui He; Juan Li; Lupeng Zeng; Tingting Chen; Yijuan Liao; Weiming Sun; Jianming Lan; Shuangmu Zhuo; Jing Zhang; Huanghao Yang; Jinghua Chen
Source:
Analytical chemistry 2019 v.91 no.13 pp. 8406-8414
ISSN:
1520-6882
Subject:
Danio rerio; copper; electrochemistry; enzymes; exosomes; fluorescence; image analysis; models; neoplasms; organic matter; photostability; protein content; river water
Abstract:
... Compared with plenty of single-functional molecules, multifunctional molecules are scarce and have high demand in further research. In this work, a multifunctional molecule called 10-methyl-2-amino-acridone (MAA) is presented. Interestingly, MAA simultaneously features electrochemistry, two-photon fluorescence, visible-light-induced oxidase mimic, and photoelectrochemistry (PEC) activity, and the ...
DOI:
10.1021/acs.analchem.9b01289

16. Additives migrating from 3D-printed plastic induce developmental toxicity and neuro-behavioural alterations in early life zebrafish (Danio rerio)

Author:
Milanga Walpitagama; Megan Carve; Alon M. Douek; Charlene Trestrail; Yutao Bai; Jan Kaslin; Donald Wlodkowic
Source:
Aquatic toxicology 2019 v.213 pp. 105227
ISSN:
0166-445X
Subject:
Danio rerio; acetylcholinesterase; additives; apoptosis; ascorbic acid; caspases; embryogenesis; environmental assessment; environmental hazards; environmental impact; enzyme inhibitors; gas chromatography-mass spectrometry; glutathione transferase; habituation; larvae; leachates; lethal concentration 50; lipid peroxidation; locomotion; mortality; motor neurons; muscles; neurotoxicity; paralysis; phenotype; plastics; risk assessment; superoxide dismutase; teratogenicity; toxic substances; wastes
Abstract:
... The environmental impact of exposure to 3D-printed plastics as well as potential migration of toxic chemicals from 3D-printed plastics remains largely unexplored. In this work we applied leachates from plastics fabricated using a stereolithography (SLA) process to early developmental stages of zebrafish (Danio rerio) to investigate developmental toxicity and neurotoxicity. Migration of unpolymeriz ...
DOI:
10.1016/j.aquatox.2019.105227

17. Advancing the Zebrafish embryo test for endocrine disruptor screening using micro‐injection: Ethinyl estradiol as a case study

Author:
Ellen D. G. Michiels; Lucia Vergauwen; Foon Yin Lai; Raewyn M. Town; Adrian Covaci; Alexander L. N. van Nuijs; Steven J. Van Cruchten; Dries Knapen
Source:
Environmental toxicology and chemistry 2019 v.38 no.3 pp. 533-547
ISSN:
0730-7268
Subject:
Danio rerio; abnormal development; absorbed dose; aromatase; biomarkers; brain; case studies; dose response; droplet size; embryo (animal); endocrine-disrupting chemicals; estradiol; estrogen receptors; exposure pathways; fish; guidelines; hydrophobicity; models; screening; solvents; toxicity testing; vitellogenin
Abstract:
... Fish (embryo) toxicity test guidelines are mostly based on aquatic exposures. However, in some cases, other exposure routes can be more practical and relevant. Micro‐injection into the yolk of fish embryos could offer a particular advantage for administering hydrophobic compounds, such as many endocrine disruptors. Single‐dose micro‐injection was compared with continuous aquatic exposure in terms ...
DOI:
10.1002/etc.4343

18. Agaricus bisporus-derived β-glucan prevents obesity through PPAR γ downregulation and autophagy induction in zebrafish fed by chicken egg yolk

Author:
Xiumin Li; Yu Xue; Liang Pang; Bo Len; Zhichao Lin; Jiafu Huang; Zhaoshui ShangGuan; Yutian Pan
Source:
International journal of biological macromolecules 2019 v.125 pp. 820-828
ISSN:
0141-8130
Subject:
Agaricus bisporus; Danio rerio; adipocytes; adiposity; autophagy; beta-glucans; diet; dose response; egg yolk; larvae; lipid metabolism; lipids; obesity; peroxisome proliferator-activated receptor gamma
Abstract:
... β-(1,4)-d-Glucan with (1,2) and (1,6)-linked branches (short for β-glucan), extracted from Agaricus bisporus (Lange) Sing, had significant anti-obesity and lowering-fat effect. FITC-β-glucan was absorbed by adipocytes of zebrafish larvae when stained by Nile Red. β-Glucan decreased the adiposity mass, reduced the expression of ppar g, mtp, L-fabp, ifabp in ISH, which was coincident as the results ...
DOI:
10.1016/j.ijbiomac.2018.12.122

19. Allelopathically inhibitory effects of eucalyptus extracts on the growth of Microcystis aeruginosa

Author:
Wei Zhao; Zheng Zheng; JunLei Zhang; Saint-Fort Roger; XingZhang Luo
Source:
Chemosphere 2019 v.225 pp. 424-433
ISSN:
0045-6535
Subject:
Danio rerio; Eucalyptus grandis; Microcystis aeruginosa; algae; allelochemicals; aquatic environment; berberine; cell membranes; ecophysiology; enzyme activity; enzyme inhibition; esterases; eutrophication; gallic acid; grasses; leaves; mechanism of action; photosynthesis; roots; species abundance; stems; surface water; synergism; toxicity; Washington (state)
Abstract:
... Microcystis aeruginosa (M. aeruginosa), as the dominant algae in eutrophic water bodies, has caused a serious harm to the local eco-environment. A biological tool, employing allelopathic inhibitory of eucalyptus to control M. aeruginosa, has been receiving tremendous attention. This work presents the results of the allelopathic inhibitory effects of eucalyptus (Eucalyptus grandis × E.urophylla ‘GL ...
DOI:
10.1016/j.chemosphere.2019.03.070

20. Altered Gene expression of ABC transporters, nuclear receptors and oxidative stress signaling in zebrafish embryos exposed to CdTe quantum dots

Author:
Jingjing Tian; Jia Hu; Guangxing Liu; Huancai Yin; Mingli Chen; Peng Miao; Pengli Bai; Jian Yin
Source:
Environmental pollution 2019 v.244 pp. 588-599
ISSN:
0269-7491
Subject:
Danio rerio; P-glycoproteins; adenosine; biomarkers; embryo (animal); gene expression regulation; glutathione; hatching; oxidative stress; peroxisome proliferator-activated receptors; pollutants; pregnanes; protective effect; quantum dots; superoxide dismutase; toxicity
Abstract:
... Adenosine triphosphate-binding cassette (ABC) transporters, including P-glycoprotein (Pgp) and multi-resistance associated proteins (Mrps), have been considered important participants in the self-protection of zebrafish embryos against environmental pollutants, but their possible involvement in the efflux and detoxification of quantum dots (QDs), as well as their regulation mechanism are currently ...
DOI:
10.1016/j.envpol.2018.10.092

21. An Eco- and User-Friendly Herbicide

Author:
Xiangjun Zhang; Qiaoxian Huang; Zhe-Ze Zhao; Xiaoqiu Xu; Shengke Li; Hang Yin; Lanlan Li; Jianxiang Zhang; Ruibing Wang
Source:
Journal of agricultural and food chemistry 2019 v.67 no.28 pp. 7783-7792
ISSN:
1520-5118
Subject:
Danio rerio; animal models; apoptosis; ecosystems; fish; gardening; hematologic tests; hepatotoxicity; herbicidal properties; macrocyclic compounds; mixing; paraquat; reactive oxygen species; survival rate; viability; wildlife
Abstract:
... The increasing use of pesticides in agriculture and gardening has caused severe deterioration to both the ecosystem and the health of users (human beings), so there is an urgent need for eco- and user-friendly pesticides. Among a variety of herbicides, paraquat (PQ), frequently used as an effective herbicidal agent worldwide, is well-known for its serious toxicity that has killed, and harmed, thou ...
DOI:
10.1021/acs.jafc.9b00764

22. An innovative photoreactor, FluHelik, to promote UVC/H2O2 photochemical reactions: Tertiary treatment of an urban wastewater

Author:
Jonathan C. Espíndola; Raquel O. Cristóvão; Sara R.F. Araújo; Teresa Neuparth; Miguel M. Santos; Rosa Montes; José B. Quintana; Rosario Rodil; Rui A.R. Boaventura; Vítor J.P. Vilar
Source:
Science of the total environment 2019 v.667 pp. 197-207
ISSN:
0048-9697
Subject:
Danio rerio; bioassays; drugs; embryo (animal); embryotoxicity; hydrogen peroxide; laws and regulations; mineralization; models; oxidation; oxytetracycline; photochemical reactions; wastewater
Abstract:
... An innovative photoreactor, FluHelik, was used to promote the degradation of contaminants of emerging concern (CECs) by a photochemical UVC/H2O2 process. First, the system was optimized for the oxidation of a model antibiotic, oxytetracycline (OTC), using both ultrapure water (UPW) and a real urban wastewater (UWW) (collected after secondary treatment) as solution matrices. Following, the process ...
DOI:
10.1016/j.scitotenv.2019.02.335

23. Animal models of leukodystrophy: a new perspective for the development of therapies

Author:
Holly A. Rutherford; Noémie Hamilton
Source:
FEBS journal 2019 v.286 no.21 pp. 4176-4191
ISSN:
1742-464X
Subject:
Danio rerio; animal models; cognitive disorders; high-throughput nucleotide sequencing; humans; mice; pathogenesis; patients; signs and symptoms (animals and humans); therapeutics
Abstract:
... The leukodystrophies are a family of heritable disorders characterised by white matter degeneration, accompanied by variable clinical symptoms including loss of motor function and cognitive decline. Now thought to include over 50 distinct disorders, there are a vast array of mechanisms underlying the pathology of these monogenic conditions and, accordingly, a range of animal models relating to eac ...
DOI:
10.1111/febs.15060

24. Ankrd45 Is a Novel Ankyrin Repeat Protein Required for Cell Proliferation

Author:
Yunsi Kang; Haibo Xie; Chengtian Zhao
Source:
Genes 2019 v.10 no.6 pp. -
ISSN:
2073-4425
Subject:
CRISPR-Cas systems; Danio rerio; apoptosis; cell lines; cell proliferation; cilia; cytokinesis; early development; gene editing; genes; histology; human diseases; larvae; liver; mammals; mitosis; mutants; mutation; neoplasms; prokaryotic cells; proteins; small interfering RNA; tissues
Abstract:
... Ankyrin repeats, the most common protein–protein interaction motifs in nature, are widely present in proteins of both eukaryotic and prokaryotic cells. Ankyrin repeat-containing proteins play diverse biological functions. Here, we identified the gene ankrd45, which encodes a novel, two ankyrin repeat-containing protein. Zebrafish ankrd45 displayed a tissue specific expression pattern during ...
DOI:
10.3390/genes10060462
PubMed:
31208154
PubMed Central:
PMC6628321

25. Anti-Inflammatory Activity of a Peptide from Skipjack (Katsuwonus pelamis)

Author:
Zhi-gao Wang; Xiao-guo Ying; Peng Gao; Chun-li Wang; Yi-fan Wang; Xin-wei Yu; Jing Chen; Bin Wang; Hong-yu Luo
Source:
Marine drugs 2019 v.17 no.10 pp. -
ISSN:
1660-3397
Subject:
Danio rerio; Katsuwonus pelamis; adjuvants; anti-inflammatory activity; bacteria; blood serum; body weight changes; byproducts; colitis; colon; diarrhea; inflammation; interleukin-10; interleukin-6; intestinal microorganisms; mice; microscopy; models; neutrophils; probiotics; species diversity; sulfasalazine; therapeutics; tumor necrosis factor-alpha; villi; virulent strains
Abstract:
... In this paper, the effect of skipjack (Katsuwonus pelamis) enzymatic peptide (SEP), which was prepared and purified from a byproduct of skipjack, on inflammation, ulcerative colitis and the regulation of intestinal flora was studied in a mouse ulcerative colitis model and a transgenic zebrafish inflammation model. The aggregation of transgenic granulocyte neutrophils in zebrafish from a normal env ...
DOI:
10.3390/md17100582
PubMed:
31614893
PubMed Central:
PMC6835902

26. Anti-betanodavirus activity of isoprinosine and improved efficacy using carbon nanotubes based drug delivery system

Author:
Song Zhu; Jian Li; Ai-Guo Huang; Ji-Qiu Huang; Yong-Quan Huang; Gao-Xue Wang
Source:
Aquaculture 2019 v.512 pp. 734377
ISSN:
0044-8486
Subject:
Betanodavirus; Danio rerio; Fourier transform infrared spectroscopy; antiviral agents; apoptosis; aquaculture; bovine serum albumin; carbon nanotubes; central nervous system; drug delivery systems; drugs; etiological agents; fish larvae; freshwater fish; hosts; immune response; inhibitory concentration 50; interferon-gamma; interleukin-1beta; mortality; necrosis; transmission electron microscopes; tumor necrosis factor-alpha; ultraviolet-visible spectroscopy
Abstract:
... Viral nervous necrosis (VNN) disease has caused mass mortality in cultured marine and freshwater fish worldwide, resulting in enormous economic losses in the aquaculture industry. The causative agent of VNN is betanodavirus [also known as nervous necrosis virus (NNV)], which classified as a member of the Nodaviridae family. NNV mainly infects the central nervous system (CNS) of hosts, which is pro ...
DOI:
10.1016/j.aquaculture.2019.734377

27. Anti-melanogenesis of novel kojic acid derivatives in B16F10 cells and zebrafish

Author:
Yan-Mei Chen; Wei-Chao Su; Chen Li; Yan Shi; Qing-Xi Chen; Jing Zheng; Dong-Lei Tang; Shu-Ming Chen; Qin Wang
Source:
International journal of biological macromolecules 2019 v.123 pp. 723-731
ISSN:
0141-8130
Subject:
Danio rerio; binding proteins; cAMP-dependent protein kinase; catechol oxidase; cosmetics; enzyme activity; enzyme inhibition; food science; inhibitory concentration 50; kojic acid; medicine; melanin; models; nuclear magnetic resonance spectroscopy; phosphorylation; pigmentation; transcription factors
Abstract:
... Novel kojic acid derivatives (KADs) with the potential ability to inhibit tyrosinase were synthesized and were further identified by Q-Exactive, IR and NMR. Among these compounds, KAD2 showed the best inhibitory effects on diphenolase activity and monophenolase activity, with IC₅₀ of 7.50 μM and 20.51 μM, respectively. The anti-melanogenic activity of KAD2 was further confirmed by assessing the in ...
DOI:
10.1016/j.ijbiomac.2018.11.031

28. Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity

Author:
Shahida Parveen; Muhammad Hanif; Euphemia Leung; Kelvin K. H. Tong; Annie Yang; Jonathan Astin; Gayan H. De Zoysa; Tasha R. Steel; David Goodman; Sanam Movassaghi; Tilo Söhnel; Vijayalekshmi Sarojini; Stephen M. F. Jamieson; Christian G. Hartinger
Source:
Chemical communications 2019 v.55 no.80 pp. 12016-12019
ISSN:
1364-548X
Subject:
DNA damage; Danio rerio; antineoplastic activity; chemical compounds; chemical reactions; cisplatin; hemolysis; mechanism of action; models; neoplasm cells; neoplasms; reactive oxygen species; toxicity
Abstract:
... Redox-modulating anticancer drugs allow the exploitation of altered redox biology observed in many cancer cells. We discovered dinuclear Rhᴵᴵᴵ(Cp*) and Irᴵᴵᴵ(Cp*) complexes that have in vitro anticancer activity superior to cisplatin and the investigational drug IT-139, while being less toxic in haemolysis and in vivo zebrafish models. The mode of action appears to be related to DNA damage and ROS ...
DOI:
10.1039/c9cc03822a

29. Antioxidant and anti-inflammatory effects of an ethanol fraction from the Schisandra chinensis baillon hot water extract fermented using Lactobacilius paracasei subsp. tolerans

Author:
Jung Yoon Yang; Geum Ran Kim; Jin Sil Chae; Hyemin Kan; Seong Soon Kim; Kyu-Seok Hwang; Byung Hoi Lee; Sangcheol Yu; Seongcheol Moon; Byounghee Park; Myung Ae Bae; Dae-Seop Shin
Source:
Food science and biotechnology 2019 v.28 no.6 pp. 1759-1767
ISSN:
1226-7708
Subject:
Danio rerio; Schisandra chinensis; antioxidants; biotechnology; byproducts; ethanol; fermentation; food industry; food science; gene expression; immune response; interleukin-6; lipopolysaccharides; neutrophils; nitric oxide; protein secretion; waste management
Abstract:
... Waste management is a major part of the food industry. The present study was designed to utilize the discarded byproduct of Schisandra chinensis Baillon. The antioxidant and anti-inflammatory effects of a 30% ethanol fraction (RPG-OM-30E) from the fermented hot water extraction of the Schisandra chinensis Baillon byproduct were investigated using RAW 264.7 cells and zebrafish larvae. RPG-OM-30E re ...
DOI:
10.1007/s10068-019-00626-4
PubMed:
31807348
PubMed Central:
PMC6859149

30. Antiviral activity of anisomycin against spring viraemia of carp virus in epithelioma papulosum cyprini cells and zebrafish

Author:
Yu-Feng Shen; Yang Hu; Bin Zhu; Gao-Xue Wang
Source:
Virus research 2019 v.268 pp. 38-44
ISSN:
0168-1702
Subject:
Carp sprivivirus; Danio rerio; Streptomyces griseolus; antiviral properties; aquaculture; carp; cytopathogenicity; gene expression; glycoproteins; inhibitory concentration 50; intraperitoneal injection; kidneys; messenger RNA; metabolites; nucleoproteins; phosphoproteins; spleen; survival rate; therapeutics; viremia
Abstract:
... Spring viraemia of carp (SVC) caused by spring viraemia of carp virus (SVCV) is an acute and highly lethal viral disease of cyprinid fish. However, effective therapy for SVC is still scarce until now. Here we evaluated the inhibition of anisomycin (Ani), a metabolite produced by Streptomyces griseolus, on the replication of SVCV in vitro and in vivo. Our results demonstrated that Ani could suppres ...
DOI:
10.1016/j.virusres.2019.05.013
PubMed:
31136824
PubMed Central:
PMC7114655

31. Antiviral activity of palmitic acid via autophagic flux inhibition in zebrafish (Danio rerio)

Author:
Marta Librán-Pérez; Patricia Pereiro; Antonio Figueras; Beatriz Novoa
Source:
Fish & shellfish immunology 2019 v.95 pp. 595-605
ISSN:
1050-4648
Subject:
Carp sprivivirus; Danio rerio; antiviral properties; autophagy; cell proliferation; fish; immune response; immunostimulants; interferons; models; morbidity; mortality; neutrophils; nutrition; palmitic acid; viral load
Abstract:
... Fatty acids (FAs) are key elements that affect not only growth but also different immune functions, and therefore, nutrition is important for growing healthy fish. Zebrafish (Danio rerio) is a good model for assessing the beneficial effects of immunostimulants, including FAs, before applying them in aquaculture. Accordingly, this study evaluated the effects of palmitic acid (PA) treatment on diffe ...
DOI:
10.1016/j.fsi.2019.10.055

32. Assessing pH-dependent toxicity of fluoxetine in embryonic zebrafish using mass spectrometry-based metabolomics

Author:
Priti Mishra; Zhiyuan Gong; Barry C. Kelly
Source:
Science of the total environment 2019 v.650 pp. 2731-2741
ISSN:
0048-9697
Subject:
Danio rerio; amino acid metabolism; apoptosis; aquatic organisms; embryo (animal); energy; energy metabolism; excretion; gas chromatography-mass spectrometry; glucose; lipid metabolism; metabolites; metabolomics; multivariate analysis; oxidative stress; pH; toxicity; urea; wastes
Abstract:
... While it is well known that fluoxetine is more toxic to aquatic organisms at high pH, the metabolic dysregulations related to observed pH-dependent effects are still poorly understood. In the present study, we utilized a gas chromatography mass spectrometry (GC–MS) based metabolomics approach to assess metabolomic profile changes in developing zebrafish embryos following exposure (2 hpf–96 hpf) to ...
DOI:
10.1016/j.scitotenv.2018.09.364

33. Assessing the ability of zebrafish scales to contribute to the short-term homeostatic regulation of [Ca2+] in the extracellular fluid during calcemic challenges

Author:
Jacky T. Hung; Sarah E. Webb; Carla Palumbo; Agnieszka M. Lesniak; Alan M. Shipley; Alessandro Rubinacci; Joseph G. Kunkel; Andrew L. Miller
Source:
Fisheries science 2019 v.85 no.6 pp. 943-959
ISSN:
0919-9268
Subject:
Danio rerio; calcium; fish; fish culture; homeostasis; ions; mice; models; scales (integument); specific ion electrodes
Abstract:
... The elasmoid scales of fish represent a significant internal reservoir of calcium ions (Ca²⁺), but little is known about the contribution of these scales to the short-term regulation of Ca²⁺ homeostasis in the extracellular fluid (ECF). This gap in our knowledge is partly due to the technical challenges involved in measuring small Ca²⁺ fluxes around the scales of live fish in real time. Here, we d ...
DOI:
10.1007/s12562-019-01353-9

34. Assessment of the effect of methyl-triclosan and its mixture with triclosan on developing zebrafish (Danio rerio) embryos using mass spectrometry-based metabolomics

Author:
Jing Fu; Zhiyuan Gong; Sungwoo Bae
Source:
Journal of hazardous materials 2019 v.368 pp. 186-196
ISSN:
0304-3894
Subject:
Danio rerio; acetonitrile; bioavailability; biodegradation; databases; embryo (animal); gas chromatography-mass spectrometry; glucose; hydrophobicity; isopropyl alcohol; mannose; metabolism; metabolites; metabolome; metabolomics; multivariate analysis; pentose phosphate cycle; starch; sucrose; toxicity; toxicity testing; triclosan; valine; watersheds
Abstract:
... Methyl-triclosan (MTCS), as a biodegradation product from antibacterial triclosan (TCS), has been detected in water catchments, and it has also been verified to accumulate in biota due to its hydrophobicity. There is a lack, however, of toxicity studies on MTCS and its effects on organisms in conjunction with TCS. In this study, exposure experiments were conducted to assess the toxicity to embryon ...
DOI:
10.1016/j.jhazmat.2019.01.019

35. Attenuated Listeria monocytogenes protecting zebrafish (Danio rerio) against Vibrio species challenge

Author:
Chengchao Ding; Qing Liu; Jie Li; Junfei Ma; Shuying Wang; Qingli Dong; Dongpo Xu; Jingxuan Qiu; Xiang Wang
Source:
Microbial pathogenesis 2019 v.132 pp. 38-44
ISSN:
0882-4010
Subject:
Danio rerio; Listeria monocytogenes; Vibrio alginolyticus; Vibrio anguillarum; Vibrio parahaemolyticus; antigens; aquaculture; aquaculture industry; bacteria; cross immunity; fish; fish diseases; intraperitoneal injection; live vaccines; models; outer membrane proteins; survival rate; vector vaccines; vibriosis
Abstract:
... Live attenuated bacteria is a promising candidate vector for the delivery of vaccines in clinic trials. In the field of aquaculture industry, live vector vaccine also could provide long-term and effective protection against fish bacterial diseases. In our previous work, we demonstrated attenuated Listeria monocytogenes (Lm) had the potential to be an aquaculture vaccine vector in cellular level an ...
DOI:
10.1016/j.micpath.2019.03.040

36. Behavioral studies of stimulus learning in zebrafish larvae

Author:
Ruth M. Colwill
Source:
Behavioural processes 2019 v.164 pp. 150-156
ISSN:
0376-6357
Subject:
Danio rerio; larvae; learning
Abstract:
... Within a week of fertilization, a zebrafish larva has developed a robust behavioral repertoire that includes the ability to learn about noncontingent stimuli. I begin this paper with a brief review of the t1-t2 framework in which groups receive different experiences at the first time point (t1) followed by a common assessment at the second time point (t2) and the strengths of this framework for st ...
DOI:
10.1016/j.beproc.2019.04.005
PubMed:
31054948
PubMed Central:
PMC6744834

37. Behavioral toxicity of tannery effluent in zebrafish (Danio rerio) used as model system

Author:
Thales Quintão Chagas; Tenilce Gabriela da Silva Alvarez; Mateus Flores Montalvão; Carlos Mesak; Thiago Lopes Rocha; Amanda Pereira da Costa Araújo; Guilherme Malafaia
Source:
Science of the total environment 2019 v.685 pp. 923-933
ISSN:
0048-9697
Subject:
Danio rerio; Oreochromis niloticus; Poecilia; adults; animal models; animals; antipredatory behavior; behavior change; bioaccumulation; chromium; chronic exposure; ecotoxicology; fish behavior; magnesium; neurotoxicity; pollution; sodium; tannery effluents; tranquilizers
Abstract:
... The ecotoxicity of untreated tannery effluent (UTE) in several animal models has been reported; however, its effects on fish behavior, and neurotoxicity, remain unknown. Thus, the hypothesis that the chronic exposure to UTE can induce behavioral changes in adult zebrafish (Danio rerio) representatives, even when it is highly diluted in water, was tested. Animals exposed to 0.1% and 0.3% UTE for 30 ...
DOI:
10.1016/j.scitotenv.2019.06.253

38. Behavioral, molecular and physiological responses of embryo-larval zebrafish exposed to types I and II pyrethroids

Author:
Olushola M. Awoyemi; Naveen Kumar; Cassandra Schmitt; Seenivasan Subbiah; Jordan Crago
Source:
Chemosphere 2019 v.219 pp. 526-537
ISSN:
0045-6535
Subject:
Danio rerio; aquatic organisms; bifenthrin; deltamethrin; edema; embryo (animal); esfenvalerate; esterases; fenvalerate; lambda-cyhalothrin; larvae; messenger RNA; neurotoxins; nontarget organisms; pericardium; permethrin; physiological response; pyrethrins; reactive oxygen species; swimming; toxicity
Abstract:
... Pyrethroids are potent neurotoxicants that may elicit multiple pathways of toxicity in non-target organisms. Comparative studies on the mechanistic and developmental effects of types I and II pyrethroids against non-target aquatic species are limited. This study assessed the effects of the two pyrethroid types against embryo-larval zebrafish (Danio rerio) at environmentally relevant and laboratory ...
DOI:
10.1016/j.chemosphere.2018.12.026

39. Bimodal Visualization of Endogenous Nitric Oxide in Lysosomes with a Two-Photon Iridium(III) Phosphorescent Probe

Author:
Weijun Wu; Ruilin Guan; Xinxing Liao; Xu Yan; Thomas W. Rees; Liangnian Ji; Hui Chao
Source:
Analytical chemistry 2019 v.91 no.15 pp. 10266-10272
ISSN:
1520-6882
Subject:
Danio rerio; animal models; autophagy; image analysis; inflammation; iridium; lysosomes; macrophages; moieties; morpholine; nitric oxide; pH; phosphorescence; photostability
Abstract:
... Nitric oxide (NO) is a fundamental signaling molecule that shows complex effects on the catabolic autophagy process, which is closely linked with lysosomal function. In this study, a new lysosome-targeted, pH-independent, and two-photon phosphorescent iridium(III) complex, Ir-BPDA, has been investigated for endogenous NO detection and imaging. The rational design of the probe, as the addition of t ...
DOI:
10.1021/acs.analchem.9b02415

40. Binding and potential antibiofilm activities of Amaranthus proteins against Candida albicans

Author:
Rajamohamed Beema Shafreen; Siddharthan Seema; Alma Leticia Martinez-Ayala; María A Lozano-Grande; Maribel Robles-Sánchez; Arkadiusz Szterk; Michael Grishko; Ezra Hanuka; Elena Katrich; Shela Gorinstein
Source:
Colloids and surfaces 2019 v.183 pp. 110479
ISSN:
0927-7765
Subject:
Amaranthus hypochondriacus; Araneae; Candida albicans; Danio rerio; Fourier transform infrared spectroscopy; antidepressants; antifungal properties; antioxidant activity; biofilm; biopolymers; denaturation; diet; differential scanning calorimetry; edible films; embryo (animal); fluorescence; fluorescence emission spectroscopy; human serum albumin; hyphae; patients; protein isolates; therapeutics; thermal stability; urea; virulence; yeasts
Abstract:
... In the present study evaluation of structural, thermal and antifungal properties of Amaranthus hypochondriacus laboratory protein isolate (ALMA) and commercially available Amaranthus protein dietary antidepressant (APGM) was done by differential scanning calorimetry (DSC), Fourier Transform Infrared (FTIR) and fluorescence spectroscopy and antibiofilm activities against Candida albicans. The resul ...
DOI:
10.1016/j.colsurfb.2019.110479

41. Bioassay system for the detection of aryl hydrocarbon receptor agonists in waterborne pesticides using zebrafish cyp1a1 promoter-luciferase recombinant hepatic cells

Author:
Yixi Zhou; Chao Shen; Hong Du; Yuanyuan Bao; Chengyong He; Chonggang Wang; Zhenghong Zuo
Source:
Chemosphere 2019 v.220 pp. 61-68
ISSN:
0045-6535
Subject:
Danio rerio; agonists; aquatic animals; aquatic environment; bioassays; detection limit; gene expression; human cell lines; luciferase; mepanipyrim; messenger RNA; models; pencycuron; plasmids; quinoxyfen; risk assessment; surface water; tetrachlorodibenzo-p-dioxin
Abstract:
... Currently used pesticides are widely distributed in surface water. Most of them are harmful to aquatic animals. In the present study, a novel recombinant hepatic cell line was developed for detecting the activity of aryl hydrocarbon receptor (AhR) agonists, and their potential bio-toxicity to aquatic animals was evaluated. First, HepG2 cells were stably transfected with a luciferase reporter plasm ...
DOI:
10.1016/j.chemosphere.2018.12.115

42. Bioconcentration and Metabolic Effects of Emerging PFOS Alternatives in Developing Zebrafish

Author:
Wenqing Tu; Rubén Martínez; Laia Navarro-Martin; Daniel J. Kostyniuk; Christine Hum; Jing Huang; Mi Deng; Yuanxiang Jin; Hing Man Chan; Jan Alexander Mennigen
Source:
Environmental science & technology 2019 v.53 no.22 pp. 13427-13439
ISSN:
1520-5851
Subject:
Danio rerio; energy expenditure; environmental science; feed intake; glucokinase; markets; sodium; sulfonates; transcription (genetics); wildlife
Abstract:
... The novel PFOS alternatives, 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) and sodium p-perfluorous nonenoxybenzenesulfonate (OBS), are emerging in the Chinese market, but little is known about their ecological risks. In this study, zebrafish embryos were exposed to PFOS, F-53B, and OBS to evaluate their bioconcentration and acute metabolic consequences. Per- and polyfluoroalkyl substanc ...
DOI:
10.1021/acs.est.9b03820

43. Bioconcentration and tissue distribution of shorter and longer chain perfluoroalkyl acids (PFAAs) in zebrafish (Danio rerio): Effects of perfluorinated carbon chain length and zebrafish protein content

Author:
Wu Wen; Xinghui Xia; Dong Zhou; Haotian Wang; Yawei Zhai; Hui Lin; Jian Chen; Diexuan Hu
Source:
Environmental pollution 2019 v.249 pp. 277-285
ISSN:
0269-7491
Subject:
Danio rerio; aquatic animals; bioaccumulation factor; blood; blood-brain barrier; brain; liver; muscles; perfluoroalkyl acids; perfluorocarbons; pollutants; protein content; tissue distribution; tissues
Abstract:
... Perfluoroalkyl acids (PFAAs) are a class of emerging pollutants. However, the bioconcentration and tissue distribution of shorter chain PFAAs in aquatic animals are not well understood. Here, we investigated the effects of perfluorinated carbon chain length of PFAAs and protein content of tissues on the bioconcentration and tissue distribution of both shorter chain PFAAs (linear C-F = 3–6) and lon ...
DOI:
10.1016/j.envpol.2019.03.003

44. Biological effects of the benzotriazole ultraviolet stabilizers UV-234 and UV-320 in early-staged zebrafish (Danio rerio)

Author:
Xuefang Liang; Ondrej Adamovsky; Christopher L. Souders; Christopher J. Martyniuk
Source:
Environmental pollution 2019 v.245 pp. 272-281
ISSN:
0269-7491
Subject:
Danio rerio; aquatic ecosystems; bioaccumulation; developmental toxicity; embryo (animal); embryogenesis; energy metabolism; fish; gene expression regulation; hatching; immune system; interleukin-8; larvae; locomotion; mechanism of action; messenger RNA; mitochondria; risk; stabilizers; triazoles
Abstract:
... Among the benzotriazole ultraviolet stabilizers (BUVSs), UV-234 and UV-320 are frequently detected in aquatic ecosystem. Despite the fact that these chemicals are present in low ng/L levels in surface water, they show high bio-accumulation potential and pose exposure risks to aquatic organisms. However, there are limited toxicological data available in fish. In this study, zebrafish embryos were e ...
DOI:
10.1016/j.envpol.2018.10.130

45. Biologically safe colloidal suspensions of naked iron oxide nanoparticles for in situ antibiotic suppression

Author:
Massimiliano Magro; Davide Baratella; Simone Molinari; Andrea Venerando; Gabriella Salviulo; Giulia Chemello; Ike Olivotto; Giorgio Zoppellaro; Juri Ugolotti; Claudia Aparicio; Jiri Tucek; Anna P. Fifi; Giuseppe Radaelli; Radek Zboril; Fabio Vianello
Source:
Colloids and surfaces 2019 v.181 pp. 102-111
ISSN:
0927-7765
Subject:
Danio rerio; Escherichia coli; animal models; antibacterial properties; bacteria; colloidal properties; colloids; drugs; ferric oxide; ligands; maghemite; magnetism; nanoparticles; oxytetracycline; remediation; tanks; toxicity
Abstract:
... A category of naked maghemite nanoparticles (γ-Fe₂O₃), named surface active maghemite nanoparticles (SAMNs), is characterized by biological safety, high water colloidal stability and a surface chemistry permitting the binding of ligands. In the present study, the interaction between SAMNs and an antibiotic displaying chelating properties (oxytetracycline, OxyTC) was extensively structurally and ma ...
DOI:
10.1016/j.colsurfb.2019.05.036

46. Biomaterial substrate-derived compact cellular spheroids mimicking the behavior of pancreatic cancer and microenvironment

Author:
Chui-Wei Wong; Hao-Wei Han; Yu-Wen Tien; Shan-hui Hsu
Source:
Biomaterials 2019 v.213 pp. 119202
ISSN:
0142-9612
Subject:
Danio rerio; adenocarcinoma; biocompatible materials; cell structures; chitosan; coculture; drugs; humans; hyaluronic acid; metastasis; models; neoplasm cells; pancreatic neoplasms; patients; phenotype; prognosis; screening; stromal cells; therapeutics
Abstract:
... Pancreatic stromal cells especially pancreatic stellate cells (PSCs) play a critical role in the progression of human pancreatic ductal adenocarcinoma (PDAC). However, the exact interaction between cancer cells and PSCs remains to be elucidated in order to develop more effective therapeutic approaches to treat PDAC. The microenvironment of PDAC shows higher hyaluronan (HA) levels, which is associa ...
DOI:
10.1016/j.biomaterials.2019.05.013

47. Biomimetic Accumulation of Methamphetamine and Its Metabolite Amphetamine by Diffusive Gradients in Thin Films to Estimate Their Bioavailability in Zebrafish

Author:
Xingxing Yin; Changsheng Guo; Jiapei Lv; Song Hou; Yan Zhang; Xiaowei Jin; Yanguo Teng; Jian Xu
Source:
Environmental science & technology letters 2019 v.6 no.12 pp. 708-713
ISSN:
2328-8930
Subject:
Danio rerio; amphetamine; bioaccumulation; bioavailability; biomimetics; biotransformation; films (materials); fish; metabolites; methamphetamines
Abstract:
... In this study, we evaluated the application of the diffusive gradient in the thin films (DGT) technique to predict the bioavailability of methamphetamine (METH) and its metabolite, amphetamine (AMP), in zebrafish (Danio rerio). We simultaneously exposed zebrafish and DGT devices to water spiked with different concentrations of METH. Subsequently, METH and its major metabolite, AMP, were quantified ...
DOI:
10.1021/acs.estlett.9b00669

48. Biotechnological potential of a cysteine protease (CpCP3) from Calotropis procera latex for cheesemaking

Author:
Maria Z.R. Silva; João P.B. Oliveira; Márcio V. Ramos; Davi F. Farias; Chayenne A. de Sá; Juliana A.C. Ribeiro; Ayrles F.B. Silva; Jeanlex S. de Sousa; Rafael A. Zambelli; Ana C. da Silva; Gilvan P. Furtado; Thalles B. Grangeiro; Mirele S. Vasconcelos; Sandro R. Silveira; Cleverson D.T. Freitas
Source:
Food chemistry 2019 pp. -
ISSN:
0308-8146
Subject:
Calotropis procera; Danio rerio; Escherichia coli; allergenicity; atomic force microscopy; cattle; cheesemaking; cheeses; chymosin; cysteine proteinases; embryo (animal); kappa-casein; latex; metal ions; micelles; peptides; sensory evaluation; water content
Abstract:
... This article reports the characterization and evaluation of the biotechnological potential of a cysteine protease purified from Calotropis procera (CpCP3). This enzyme was highly stable to different metal ions and was able to hydrolyze κ-casein similarly to bovine chymosin. Atomic force microscopy showed that the process of casein micelle aggregation induced by CpCP3 was similar to that caused by ...
DOI:
10.1016/j.foodchem.2019.125574

49. Black Raspberry (Rubus coreanus Miquel) Promotes Browning of Preadipocytes and Inguinal White Adipose Tissue in Cold-Induced Mice

Author:
Woo Yong Park; Seong-Kyu Choe; Jinbong Park; Jae-Young Um
Source:
Nutrients 2019 v.11 no.9 pp. -
ISSN:
2072-6643
Subject:
Danio rerio; Rubus coreanus; Rubus occidentalis; active ingredients; adipocytes; ellagic acid; heat production; humans; lipids; mesenchymal stromal cells; mice; models; obesity; oral administration; peroxisome proliferator-activated receptor gamma; temperature; white adipose tissue; zinc finger motif
Abstract:
... The alteration of white adipose tissue (WAT) “browning”, a change of white into beige fat, has been considered as a new therapeutic strategy to treat obesity. In this study, we investigated the browning effect of black raspberry (Rubus coreanus Miquel) using in vitro and in vivo models. Black raspberry water extract (BRWE) treatment inhibited lipid accumulation in human mesenchymal ste ...
DOI:
10.3390/nu11092164
PubMed:
31509935
PubMed Central:
PMC6769844

50. Butylated Hydroxyanisole Exerts Neurotoxic Effects by Promoting Cytosolic Calcium Accumulation and Endoplasmic Reticulum Stress in Astrocytes

Author:
Sunwoo Park; Jin-Young Lee; Whasun Lim; Seungkwon You; Gwonhwa Song
Source:
Journal of agricultural and food chemistry 2019 v.67 no.34 pp. 9618-9629
ISSN:
1520-5118
Subject:
Danio rerio; animal models; antioxidants; astrocytes; biomarkers; brain; butylated hydroxyanisole; calcium; caspase-3; caspase-9; cell cycle checkpoints; chelating agents; cytochrome c; cytotoxicity; embryo (animal); endoplasmic reticulum stress; genetically modified organisms; hepatotoxicity; humans; in vivo studies; inflammation; learning; mitogen-activated protein kinase; nerve tissue; neurotoxicity; non-specific serine/threonine protein kinase; nutritional support; phosphatidylinositol 3-kinase; pro-apoptotic proteins; protein synthesis; regulatory proteins; signal transduction; sleep
Abstract:
... Astrocytes provide nutritional support, regulate inflammation, and perform synaptic functions in the human brain. Although butylated hydroxyanisole (BHA) is a well-known antioxidant, several studies in animals have indicated BHA-mediated liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. However, the specific effects of BHA on human astrocytes and the un ...
DOI:
10.1021/acs.jafc.9b02899

51. CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications

Author:
Felix Schmöhl; Verena Peters; Claus Peter Schmitt; Gernot Poschet; Michael Büttner; Xiaogang Li; Tim Weigand; Tanja Poth; Nadine Volk; Jakob Morgenstern; Thomas Fleming; Peter P. Nawroth; Jens Kroll
Source:
Cellular and molecular life sciences 2019 v.76 no.22 pp. 4551-4568
ISSN:
1420-682X
Subject:
Danio rerio; amino acid composition; amino acid metabolism; amino acids; biochemical pathways; carnosine; diabetic nephropathy; enzymes; genes; kidneys; overfeeding; weight gain
Abstract:
... The gene CNDP1 was associated with the development of diabetic nephropathy. Its enzyme carnosinase 1 (CN1) primarily hydrolyzes the histidine-containing dipeptide carnosine but other organ and metabolic functions are mainly unknown. In our study we generated CNDP1 knockout zebrafish, which showed strongly decreased CN1 activity and increased intracellular carnosine levels. Vasculature and kidneys ...
DOI:
10.1007/s00018-019-03127-z

52. Cancer-associated fibroblast regulate proliferation and migration of prostate cancer cells through TGF-β signaling pathway

Author:
Dai-Yu Sun; Jia-Qi Wu; Zhi-Heng He; Ming-Fang He; Hong-Bin Sun
Source:
Life sciences 2019 pp. -
ISSN:
0024-3205
Subject:
Danio rerio; animal models; cell lines; cell proliferation; culture media; fibroblasts; in vitro studies; neoplasm cells; neoplasm progression; patients; prostatic neoplasms; signal transduction; transforming growth factor beta 1; transforming growth factor beta receptors
Abstract:
... Prostate cancer (PCa) incidence rates are rising in China currently. Cancer-associated fibroblasts (CAFs), as a major component of tumor microenvironment, are crucial for tumor progression. This study was aimed to explore the promotion effect of patient-derived CAFs on the proliferation and migration of prostate cancer cells.CAFs were isolated from tumor tissues of PCa patients. The promotion effe ...
DOI:
10.1016/j.lfs.2019.116791

53. Capillary zone electrophoresis-tandem mass spectrometry with ultraviolet photodissociation (213 nm) for large-scale top–down proteomics

Author:
Elijah N. McCool; Daoyang Chen; Wenxue Li; Yansheng Liu; Liangliang Sun
Source:
Analytical methods 2019 v.11 no.22 pp. 2855-2861
ISSN:
1759-9679
Subject:
Danio rerio; acetylation; brain; calmodulin; data collection; fractionation; gases; gel chromatography; molecular weight; myristoylation; photolysis; photons; post-translational modification; proteomics; tandem mass spectrometry
Abstract:
... Capillary zone electrophoresis-tandem mass spectrometry (CZE-MS/MS) has attracted attention recently for large-scale top–down proteomics that aims to characterize proteoforms in cells at a global scale with high throughput. In this work, CZE-MS/MS with ultraviolet photodissociation (UVPD) was evaluated for large-scale top–down proteomics for the first time. Roughly, 600 proteoforms and 369 protein ...
DOI:
10.1039/c9ay00585d
PubMed:
31608127
PubMed Central:
PMC6788745

54. Cationic cyanine chromophore-assembled upconversion nanoparticles for sensing and imaging H2S in living cells and zebrafish

Author:
Fangfang Wang; Cuiling Zhang; Xuetong Qu; Shasha Cheng; Yuezhong Xian
Source:
Biosensors & bioelectronics 2019 v.126 pp. 96-101
ISSN:
0956-5663
Subject:
Danio rerio; biosensors; cytotoxicity; hydrogen sulfide; image analysis; light intensity; monitoring; nanoparticles; polyacrylic acid
Abstract:
... Elevated hydrogen sulfide (H₂S) level is closely associated with various diseases. So the sensing of H₂S is noteworthy for divulging its role in diagnosing these diseases. Herein, we proposed poly(acrylic acid)-modified upconversion nanoparticles assembled with cationic near-infrared cyanine chromophores (Cy7-Cl) as the nanoprobe (Cy7-UCNPs) for monitoring H₂S based on thiolation reactions. The pr ...
DOI:
10.1016/j.bios.2018.10.056

55. Characterisation of amphioxus protein kinase C-δ/θ reveals a unique proto-V3 domain suggesting an evolutionary mechanism for PKC-θ unique V3

Author:
Zhi-long Chen; Bei-Ni Gong; Qi-long Wang; Zhi-hui Xiao; Chong Deng; Wen-qian Wang; Yingqiu Li
Source:
Fish & shellfish immunology 2019 v.84 pp. 1100-1107
ISSN:
1050-4648
Subject:
Danio rerio; Drosophila; Homo sapiens; T-lymphocytes; adaptive immunity; ancestry; fish; immunological synapse; mammals; models; phylogeny; protein kinase C; shellfish; transcription factor NF-kappa B
Abstract:
... A primitive adaptive immune system has recently been suggested to be present in a basal chordate amphioxus (Branchiostoma belcheri, Bb), making it an ideal model for studying the origin of adaptive immune. The novel protein kinase C isoform PKC-θ, but not its closest isoform PKC-δ, plays a critical role for mammalian T-cell activation via translocation to immunological synapse (IS) mediated by a u ...
DOI:
10.1016/j.fsi.2018.11.001

56. Characterization and Application of Lignin–Carbohydrate Complexes from Lignocellulosic Materials as Antioxidants for Scavenging In Vitro and In Vivo Reactive Oxygen Species

Author:
Huiling Dong; Liming Zheng; Pengjun Yu; Qing Jiang; Yan Wu; Caoxing Huang; Baishuang Yin
Source:
ACS sustainable chemistry & engineering 2019 v.8 no.1 pp. 256-266
ISSN:
2168-0485
Subject:
Danio rerio; Populus; animal models; antioxidant activity; antioxidant enzymes; bamboos; enzyme activity; free radicals; glutathione peroxidase; lignin; lignocellulose; metabolism; nuclear magnetic resonance spectroscopy; oxidative stress; oxygen; reactive oxygen species; superoxide dismutase
Abstract:
... Lignin–carbohydrate complexes (LCCs) have shown antioxidant ability to scavenge the individual free radicals in vitro, while little work has been carried out to show if the LCCs can efficiently scavenge the intracellular and endogenous reactive oxygen species (ROS), which are the multiple radicals derived from the reduction of molecular oxygen during the metabolism process. In this work, carbohydr ...
DOI:
10.1021/acssuschemeng.9b05290

57. Characterization and kinetic study of the brain and muscle acetylcholinesterase from Danio rerio

Author:
Claudiane S. Marinho; Marcos V.F. Matias; Iago G.F. Brandão; Elton L. Santos; Sonia S. Machado; Carmem L.P.S. Zanta
Source:
Comparative biochemistry and physiology 2019 v.222 pp. 11-18
ISSN:
1532-0456
Subject:
Danio rerio; acetylcholinesterase; brain; enzyme kinetics; inhibitory concentration 50; muscles; organophosphorus compounds; physostigmine; temperature
Abstract:
... Acetylcholinesterase (AChE) plays an important role in the therapy of Alzheimer's disease and in the detection of pesticides such as organophosphates which are also widely used in chemical warfare. The aim of this study is the physicochemical and kinetic characterization of brain and muscle ChE from Danio rerio (Zebrafish). Optimal activity was found for brain ChE at alkaline pH 9.0 at 30 °C, and ...
DOI:
10.1016/j.cbpc.2019.04.005

58. Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos

Author:
Jeffrey J. Kelu; Sarah E. Webb; Antony Galione; Andrew L. Miller
Source:
Developmental biology 2019 v.445 no.2 pp. 211-225
ISSN:
0012-1606
Subject:
Danio rerio; Golgi apparatus; N-glycoside hydrolases; adenine; calcium; calcium signaling; cell culture; cell differentiation; embryo (animal); messenger RNA; molecular cloning; muscle development; niacin; nicotinamide; phosphates; plasma membrane; sarcoplasmic reticulum
Abstract:
... We recently demonstrated the requirement of two-pore channel type 2 (TPC2)-mediated Ca2+ release during slow muscle cell differentiation and motor circuit maturation in intact zebrafish embryos. However, the upstream trigger(s) of TPC2/Ca2+ signaling during these developmental processes remains unclear. Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+ mobilizing messenger, wh ...
DOI:
10.1016/j.ydbio.2018.11.005
PubMed:
30447180
PubMed Central:
PMC6675606

59. Characterization of paralogous uncx transcription factor encoding genes in zebrafish

Author:
Valeria Nittoli; Antonio Emidio Fortunato; Giulia Fasano; Ugo Coppola; Alessandra Gentile; Sylvie Maiella; Fernanda Langellotto; Immacolata Porreca; Raffaella De Paolo; Rita Marino; Marcella Fiengo; Aldo Donizetti; Francesco Aniello; Takashi Kondo; Filomena Ristoratore; Lorella M.T. Canzoniero; Denis Duboule; Stephen W. Wilson; Paolo Sordino
Source:
Gene 2019 v.721 pp. 100011
ISSN:
0378-1119
Subject:
Danio rerio; embryogenesis; genes; genomics; innervation; mice; nucleic acid hybridization; transcription factors
Abstract:
... The paired-type homeodomain transcription factor Uncx is involved in multiple processes of embryogenesis in vertebrates. Reasoning that zebrafish genes uncx4.1 and uncx are orthologs of mouse Uncx, we studied their genomic environment and developmental expression. Evolutionary analyses indicate the zebrafish uncx genes as being paralogs deriving from teleost-specific whole-genome duplication. Whol ...
DOI:
10.1016/j.gene.2019.100011

60. Chemical constituents of leaves of Persea americana (avocado) and their protective effects against neomycin-induced hair cell damage

Author:
SeonJu Park; Youn Hee Nam; Isabel Rodriguez; Jun Hyung Park; Hee Jae Kwak; Youngse Oh; Mira Oh; Min Seon Park; Kye Wan Lee; Jung Suk Lee; Do Hoon Kim; Yu Hwa Park; In Seok Moon; Se-Young Choung; Kwang Won Jeong; Bin Na Hong; Tong Ho Kang; Seung Hyun Kim
Source:
Revista Brasileira de Farmacognosia 2019 v.29 no.6 pp. 739-743
ISSN:
0102-695X
Subject:
Danio rerio; Persea americana; avocados; cell lines; cell viability; chemical composition; cytotoxicity; fish larvae; flavonols; glycosides; leaves; lignans; magnetism; mass spectrometry; mice; protective effect; subtropics
Abstract:
... Persea americana Mill., Lauraceae, commonly known as the avocado, is native to tropical and subtropical regions, including Brazil. From the leaves of P. americana, one previously undescribed flavonol glycoside (1) together with ten known flavonoids (2–11), four megastigmane glycosides (12–15) and two lignans (16–17) were isolated. Their structures were determined by extensive spectroscopic methods ...
DOI:
10.1016/j.bjp.2019.08.004

61. Chronic exposure to 6:2 chlorinated polyfluorinated ether sulfonate acid (F-53B) induced hepatotoxic effects in adult zebrafish and disrupted the PPAR signaling pathway in their offspring

Author:
Guohui Shi; Qianqian Cui; Jinxing Wang; Hua Guo; Yitao Pan; Nan Sheng; Yong Guo; Jiayin Dai
Source:
Environmental pollution 2019 v.249 pp. 550-559
ISSN:
0269-7491
Subject:
Danio rerio; adults; blood; chronic exposure; females; fish; gene expression; gene ontology; genes; gonads; hepatotoxicity; industry; larvae; liver; males; parents; perfluorooctane sulfonic acid; peroxisome proliferator-activated receptors; progeny; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; sulfonates; transcription (genetics); transcriptomics; triacylglycerols; wildlife
Abstract:
... As a Chinese-specific alternative to perfluorooctane sulfonate (PFOS), 6:2 chlorinated polyfluorinated ether sulfonate (commercial name: F-53B) has been used in the metal plating industry for over 40 years. This prevalence of use has resulted in its subsequent detection within the environment, wildlife, and humans. Despite this, however, its hepatotoxic effects on aquatic organisms remain unclear. ...
DOI:
10.1016/j.envpol.2019.03.032

62. Chronic exposure to dietary selenomethionine dysregulates the genes involved in serotonergic neurotransmission and alters social and antipredator behaviours in zebrafish (Danio rerio)

Author:
Anoosha Attaran; Arash Salahinejad; Adam L. Crane; Som Niyogi; Douglas P. Chivers
Source:
Environmental pollution 2019 v.246 pp. 837-844
ISSN:
0269-7491
Subject:
Danio rerio; adults; amine oxidase (flavin-containing); antipredatory behavior; brain; chronic exposure; dietary exposure; fearfulness; fish; gene expression; gene expression regulation; genes; humans; messenger RNA; metalloids; predation; risk; selenium; selenomethionine; serotonin receptors; signal transduction; social behavior; social class; swimming; tryptophan
Abstract:
... Selenium (Se) is a metalloid of potential interest from both a toxicological and nutritional perspective, having a range of safe intake. The adverse neuro-behavioural effects of Se have been investigated in both humans and fishes, but little is known about its effects on social behaviours or the serotonergic signaling pathway in the brain. In the present study, we investigated the effects of chori ...
DOI:
10.1016/j.envpol.2018.12.090

63. Circular RNAs in human and vertebrate neural retinas

Author:
Lan-Fang Sun; Bing Zhang; Xue-Jiao Chen; Xiao-Yun Wang; Bo-Wen Zhang; Yang-Yang Ji; Kun-Chao Wu; Jinyu Wu; Zi-Bing Jin
Source:
RNA biology 2019 v.16 no.6 pp. 821-829
ISSN:
1555-8584
Subject:
Danio rerio; Scandentia; brain; cell structures; chemical bonding; humans; mice; monkeys; retina; swine
Abstract:
... Circular RNAs (circRNAs) belong to an endogenous class of RNA molecules with both ends covalently linked in a circle. Although their expression pattern in the mammalian brain has been well studied, the characteristics and functions of circRNAs in retinas remain unknown. To reveal the whole expression profiles of circRNAs in the neural retina, we investigated retinal RNAs of human, monkey, mouse, p ...
DOI:
10.1080/15476286.2019.1591034
PubMed:
30874468
PubMed Central:
PMC6546369

64. Collaborative assembly of doxorubicin and galactosyl diblock glycopolymers for targeted drug delivery of hepatocellular carcinoma

Author:
Jianghua Li; Yang Zhang; Chao Cai; Xiaozhi Rong; Meng Shao; Jiarui Li; Chendong Yang; Guangli Yu
Source:
Biomaterials science 2019 v.8 no.1 pp. 189-200
ISSN:
2047-4849
Subject:
Danio rerio; Fourier transform infrared spectroscopy; acrylamides; adsorption; adverse effects; antineoplastic activity; doxorubicin; drug delivery systems; drug therapy; encapsulation; galactosamine; genetically modified organisms; hepatoma; human cell lines; hydrophilicity; models; moieties; nanoparticles; nuclear magnetic resonance spectroscopy; pain; patients; polymerization; tetrabutylammonium compounds; transmission electron microscopy
Abstract:
... Hepatocellular carcinoma (HCC) patients suffer from severe pain due to the serious systemic side effects and low efficiency of chemotherapeutic drugs, and it is important to develop novel drug delivery systems to circumvent these issues. In this study, a series of galactose-based glycopolymers, poly(N-(prop-2-enoyl)-β-d-galactopyranosylamine)-b-poly(N-isopropyl acrylamide) (pGal(OH)-b-pNIPAA), wer ...
DOI:
10.1039/c9bm01604j

65. Combination of [12]aneN₃ and Triphenylamine-Benzylideneimidazolone as Nonviral Gene Vectors with Two-Photon and AIE Properties

Author:
Ming-Xuan Liu; Le-Le Ma; Xu-Ying Liu; Jin-Yu Liu; Zhong-Lin Lu; Rui Liu; Lan He
Source:
ACS applied materials & interfaces 2019 v.11 no.46 pp. 42975-42987
ISSN:
1944-8252
Subject:
Danio rerio; absorption; carboxylic ester hydrolases; emissions; fluorescence; fluorescence emission spectroscopy; gel electrophoresis; genes; hydrophilicity; luciferase; moieties; pH; single-stranded DNA; spectral analysis; transfection
Abstract:
... Three nonviral gene vectors, TPA-BI-A/B/C, have been designed and synthesized by the combination of one or two hydrophilic [12]aneN₃ moieties and two-photon fluorescent triphenylamine-benzylideneimidazolone (TPA-BI) units through different ester linkage. Spectroscopic characterization demonstrated that TPA-BI-A/B/C had strong aggregation-induced emissions (AIE), large Stokes shifts (230, 284, and ...
DOI:
10.1021/acsami.9b15169

66. Combined effects of increased temperature and levonorgestrel exposure on zebrafish female liver, using stereology and immunohistochemistry against catalase, CYP1A, HSP90 and vitellogenin

Author:
P.G. Cardoso; R. Resende-de-Oliveira; E. Rocha
Source:
Environmental pollution 2019 v.252 pp. 1059-1067
ISSN:
0269-7491
Subject:
Danio rerio; adults; aquatic ecosystems; catalase; climate change; drugs; females; fish; glycogen; hepatocytes; immunohistochemistry; liver; metabolism; progestational hormones; temperature; toxic substances; vitellogenin
Abstract:
... Climate change and pharmaceuticals contamination constitute two of the most relevant stressors on the aquatic ecosystems, however, there is a huge lack of information regarding the interactive effects of both stressors. For that, a mesocosm experiment was implemented where adult zebrafish were exposed to combined temperature and the progestin levonorgestrel (LNG) for 21 days. Considering that the ...
DOI:
10.1016/j.envpol.2019.06.058

67. Combined effects of polystyrene microplastics and natural organic matter on the accumulation and toxicity of copper in zebrafish

Author:
Ruxia Qiao; Kai Lu; Yongfeng Deng; Hongqiang Ren; Yan Zhang
Source:
Science of the total environment 2019 v.682 pp. 128-137
ISSN:
0048-9697
Subject:
Danio rerio; adsorption; bioaccumulation; copper; heavy metals; liver; malondialdehyde; metallothionein; microplastics; organic matter; oxidative stress; pH; pollutants; polystyrenes; superoxide dismutase; toxicity; transcriptomics
Abstract:
... As emerging contaminants, microplastics (MPs) are predicted to act as vectors for other contaminants and their combined effects are largely unknown. In this study, the combined effects of MPs and natural organic matter (NOM) on the accumulation and toxicity of copper (Cu) in zebrafish (Danio rerio) were investigated. As a result, small-size MPs could absorb more Cu than large-size MPs. The presenc ...
DOI:
10.1016/j.scitotenv.2019.05.163

68. Comparative Lipid Peroxidation and Apoptosis in Embryo‐Larval Zebrafish Exposed to 3 Azole Fungicides, Tebuconazole, Propiconazole, and Myclobutanil, at Environmentally Relevant Concentrations

Author:
N. Kumar; O. Awoyemi; A. Willis; C. Schmitt; L. Ramalingam; N. Moustaid‐Moussa; J. Crago
Source:
Environmental toxicology and chemistry 2019 v.38 no.7 pp. 1455-1466
ISSN:
0730-7268
Subject:
Danio rerio; acute exposure; adverse effects; apoptosis; aquatic environment; aquatic organisms; biomarkers; caspase-3; caspase-9; cytochrome P-450; embryo (animal); gene expression; glutathione transferase; lipid peroxidation; mechanism of action; messenger RNA; mitochondria; models; myclobutanil; oxidative stress; phosphoproteins; propiconazole; runoff; tebuconazole; toxicity
Abstract:
... Azole fungicides have entered the aquatic environment through agricultural and residential runoff. In the present study, we compared the off‐target toxicity of tebuconazole, propiconazole, and myclobutanil using embryo‐larval zebrafish as a model. The aim of the present study was to investigate the relative toxicity of tebuconazole, propiconazole, and myclobutanil using multiple‐level endpoints su ...
DOI:
10.1002/etc.4429

69. Comparative studies on duplicated tdrd7 paralogs in teleosts: Molecular evolution caused neo-functionalization

Author:
Bo Wang; Xinxin Du; Huizhen Wang; Chaofan Jin; Chen Gao; Jinxiang Liu; Quanqi Zhang
Source:
Comparative biochemistry and physiology 2019 v.30 pp. 347-357
ISSN:
1744-117X
Subject:
3' untranslated regions; Danio rerio; Lepisosteus oculatus; Paralichthys olivaceus; adults; bioinformatics; embryo (animal); flounder; genes; genomics; germ cells; gonads; mammals; phylogeny; proteins; tissues; transcriptome
Abstract:
... The third-round whole genome duplication (3R-WGD) event occurred in the stem lineage of teleost during evolution, and is considered to be responsible for the biological diversification of ray-finned fishes. TUDOR domain containing protein 7 (Tdrd7), which belongs to the Tudor family proteins has been widely discussed in mammals. However, information about this gene in teleost is still lacking. In ...
DOI:
10.1016/j.cbd.2019.04.006

70. Comparative transcriptome analysis reveals the role of p53 signalling pathway during red‐spotted grouper nervous necrosis virus infection in Lateolabrax japonicus brain cells

Author:
Yangxi Xiang; Peng Jia; Wei Liu; Meisheng Yi; Kuntong Jia
Source:
Journal of fish diseases 2019 v.42 no.4 pp. 585-595
ISSN:
0140-7775
Subject:
Danio rerio; Lateolabrax japonicus; Redspotted grouper nervous necrosis virus; apoptosis; brain; freshwater fish; gene expression regulation; gene overexpression; genes; immune response; interferons; luciferase; mortality; pathogens; perch; sequence analysis; signal transduction; transcriptomics; virus replication
Abstract:
... Nervous necrosis virus (NNV) is one of the fish pathogens that have caused mass mortalities of many marine and freshwater fishes in the world. To better comprehend the molecular immune mechanism of sea perch (Lateolabrax japonicus) against NNV infection, the comparative transcriptome analysis of red‐spotted grouper nervous necrosis virus (RGNNV)‐infected or mock‐infected L. japonicus brain (LJB) c ...
DOI:
10.1111/jfd.12960
PubMed:
30659619
PubMed Central:
PMC7166548

71. Comparison of thyroid hormone disruption potentials by bisphenols A, S, F, and Z in embryo-larval zebrafish

Author:
Sangwoo Lee; Cheolmin Kim; Hyesoo Shin; Younglim Kho; Kyungho Choi
Source:
Chemosphere 2019 v.221 pp. 115-123
ISSN:
0045-6535
Subject:
Danio rerio; bisphenol A; bisphenol F; bisphenol S; blood serum; chronic exposure; epidemiological studies; fish communities; fish larvae; genes; hatching; humans; metabolism; thyroid function; thyroid hormones; transcription (genetics); urine
Abstract:
... Several structural analogues of bisphenol A (BPA), e.g., bisphenol F (BPF), bisphenol S (BPS), and bisphenol Z (BPZ), have been used as its substitutes in many applications and consequently detected in the environment, and human specimen such as urine and serum. While BPA has been frequently reported for thyroid hormone disruption in both experimental and epidemiological studies, less is known for ...
DOI:
10.1016/j.chemosphere.2019.01.019

72. Comprehensive Toxicity Assessment of PEGylated Magnetic Nanoparticles for in vivo applications

Author:
Carlos Caro; David Egea-Benavente; Rocio Polvillo; Jose Luis Royo; Manuel Pernia Leal; María Luisa García-Martín
Source:
Colloids and surfaces 2019 v.177 pp. 253-259
ISSN:
0927-7765
Subject:
Danio rerio; bioavailability; cell culture; cell viability; colloids; embryo (animal); ferrimagnetic materials; hatching; magnetic properties; magnetic resonance imaging; magnetism; manganese; mice; nanoparticles; pharmacokinetics; protocols; screening; survival rate; toxicity
Abstract:
... Magnetic nanoparticles (MNPs) represent one of the greatest promises for the development of a new generation of diagnostic agents for magnetic resonance imaging, with improved specificity and safety. Indeed, during the last decade the number of studies published in this field has grown exponentially. However, the clinical translation achieved so far has been very limited. This situation is likely ...
DOI:
10.1016/j.colsurfb.2019.01.051

73. Comprehensive chemical profiling of monascus-fermented rice product and screening of lipid-lowering compounds other than monacolins

Author:
Jin-Xiu Liang; Qun-Qun Zhang; Yan-Fei Huang; Han-Qing Pang; Xin-Guang Liu; Wen Gao; Ping Li; Hua Yang
Source:
Journal of ethnopharmacology 2019 v.238 pp. 111879
ISSN:
0378-8741
Subject:
Danio rerio; acids; amino acids; body weight changes; ergosterol; gas chromatography-mass spectrometry; glycerol; heart; hyperlipidemia; isoflavones; larvae; liquid chromatography; liver; low density lipoprotein cholesterol; mice; monacolins; nucleosides; phytosterols; red yeast rice; reference standards; screening; spectral analysis; therapeutics; traditional medicine; triacylglycerols; China
Abstract:
... Monascus-fermented rice product (MFRP) has been regarded as a dietary supplement and traditional medicine with circulation-promoting effects in China and other countries for centuries.This study was carried out to profile the chemical components in MFRP, and provide available information for elucidating the potential lipid-lowering compounds other than monacolins.High-performance liquid chromatogr ...
DOI:
10.1016/j.jep.2019.111879

74. Conditional Overexpression of rtn4al in Muscle of Adult Zebrafish Displays Defects Similar to Human Amyotrophic Lateral Sclerosis

Author:
Cheng-Yung Lin; Po-Hsiang Zhang; You-Jei Chen; Chia-Lun Wu; Huai-Jen Tsai
Source:
Marine biotechnology 2019 v.21 no.1 pp. 52-64
ISSN:
1436-2228
Subject:
Danio rerio; adults; amyotrophic lateral sclerosis; animal models; death; doxycycline; embryo (animal); gene overexpression; genetically modified organisms; humans; messenger RNA; mice; motor neurons; muscle tissues; muscles; myocytes; neurites; patients; phenotype; protein content; synapse; weight loss
Abstract:
... The protein level of muscle-specific human NogoA is abnormally upregulated in amyotrophic lateral sclerosis (ALS) mice and patients. On the other hand, while the presence of miR-206 in muscle cells delays onset and death in ALS, the relationship between these two phenomena remains unclear. Mammalian NogoA protein, also known as Reticulon 4a (Rtn4a), plays an important role in inhibiting the outgro ...
DOI:
10.1007/s10126-018-9857-x

75. Congo red dye diversely affects organisms of different trophic levels: a comparative study with microalgae, cladocerans, and zebrafish embryos

Author:
Miriam Hernández-Zamora; Fernando Martínez-Jerónimo
Source:
Environmental science and pollution research international 2019 v.26 no.12 pp. 11743-11755
ISSN:
0944-1344
Subject:
Ceriodaphnia; Congo red; Danio rerio; Daphnia magna; Selenastrum capricornutum; acute effects; aquatic ecosystems; aquatic environment; artificial colors; bioassays; color; edema; effluents; environmental law; fish communities; fish larvae; hatching; inhibitory concentration 50; lethal concentration 50; microalgae; oxygen; photosynthesis; pigments; population growth; textile industry; toxicity; trophic levels; wastewater; yolk sac
Abstract:
... Global consumption of synthetic dyes is roughly 7 × 10⁵ tons per year, of which the textile industry expends about two-thirds. Consumption of synthetic dyes produces large volumes of wastewater discharged into aquatic ecosystems. Colored effluents produce toxic effects in the hydrobionts, reduce light penetration, and alter the photosynthetic activity, causing oxygen depletion, among other effects ...
DOI:
10.1007/s11356-019-04589-1

76. Copper caused reproductive endocrine disruption in zebrafish (Danio rerio)

Author:
Jinling Cao; Guodong Wang; Tianyu Wang; Jianjie Chen; Guo Wenjing; Panhong Wu; Xinjin He; Lingtian Xie
Source:
Aquatic toxicology 2019 v.211 pp. 124-136
ISSN:
0166-445X
Subject:
Danio rerio; body weight; brain; copper; fish; fish communities; genes; gonads; histopathology; steroid hormones; surface water; transcription (genetics)
Abstract:
... Cu in surface waters has been demonstrated to affect aquatic animals at ecologically relevant concentrations. However, its effects on reproductive endocrine system and the underlying toxicological mechanisms are largely unknown. In this study, zebrafish (Danio rerio) were exposed to 0, 10, 20, 40 μg/L of Cu for 30 days. Growth, gonad histopathology, the hormone levels and the transcriptional profi ...
DOI:
10.1016/j.aquatox.2019.04.003

77. Cryoprotectants synergy improve zebrafish sperm cryopreservation and offspring skeletogenesis

Author:
Patrícia Diogo; Gil Martins; Rita Nogueira; Ana Marreiros; Paulo J. Gavaia; Elsa Cabrita
Source:
Cryobiology 2019 v.91 pp. 115-127
ISSN:
0011-2240
Subject:
DNA damage; Danio rerio; bovine serum albumin; cold stress; cryobiology; cryopreservation; cryoprotectants; egg yolk; progeny; skeletal development; sperm motility; sperm quality; viability
Abstract:
... The synergy obtained by the combination of cryoprotectants is a successful strategy that can be beneficial on the optimization of zebrafish sperm cryopreservation. Recently, a protocol was established for this species using an electric ultrafreezer (−150 °C) performing cooling rate (−66 °C/min) and storage within one step. The ultimate objective of sperm cryopreservation is to generate healthy off ...
DOI:
10.1016/j.cryobiol.2019.10.001

78. Deacetyl Ganoderic Acid F Inhibits LPS-Induced Neural Inflammation via NF-κB Pathway Both In Vitro and In Vivo

Author:
Feiya Sheng; Lele Zhang; Songsong Wang; Lele Yang; Peng Li
Source:
Nutrients 2019 v.12 no.1 pp. -
ISSN:
2072-6643
Subject:
Danio rerio; Ganoderma lucidum; anti-inflammatory activity; astrocytes; blood serum; brain; cell lines; ganoderic acid; inflammation; interleukin-6; lipopolysaccharides; medicinal fungi; mice; neurodegenerative diseases; neurons; nutrients; phosphorylation; secretion; sleep disorders; therapeutics; traditional medicine
Abstract:
... Microglia mediated neuronal inflammation has been widely reported to be responsible for neurodegenerative disease. Deacetyl ganoderic acid F (DeGA F) is a triterpenoid isolated from Ganoderma lucidum, which is a famous edible and medicinal mushroom used for treatment of dizziness and insomnia in traditional medicine for a long time. In this study the inhibitory effects and mechanisms of DeGA F aga ...
DOI:
10.3390/nu12010085

79. Degradation of endogenous proteins and generation of a null-like phenotype in zebrafish using Trim-Away technology

Author:
Xiao Chen; Mi Liu; Hongyan Lou; Yiyi Lu; Meng-Tao Zhou; Rongying Ou; Yunsheng Xu; Kai-Fu Tang
Source:
Genome biology 2019 v.20 no.1 pp. 19
ISSN:
1474-760X
Subject:
Danio rerio; antibodies; embryo (animal); embryogenesis; models; phenotype; proteins
Abstract:
... Trim-Away is a recent technique to rapidly deplete a protein from any cell type. Guided by antibodies, TRIM21 selects proteins for destruction. However, the applicability of this method in model organisms has not been investigated. Here, we show that Trim-Away can degrade proteins in zebrafish embryos. Trim-Away depletes proteins faster than morpholinos, which enables analysis of protein function ...
DOI:
10.1186/s13059-019-1624-4
PubMed:
30674345
PubMed Central:
PMC6343325

80. Degradation products and pathway of ethiprole in water and soil

Author:
Kaiying Chen; Fajun Tian; Chi Wu; Xiaohu Wu; Jun Xu; Fengshou Dong; Xingang Liu; Yongquan Zheng
Source:
Water research 2019 v.161 pp. 531-539
ISSN:
0043-1354
Subject:
Danio rerio; Daphnia magna; Selenastrum capricornutum; acute toxicity; computer software; environmental factors; hydrolysis; nuclear magnetic resonance spectroscopy; oxygen; pH; photolysis; risk; soil; soil degradation; tandem mass spectrometry
Abstract:
... Ethiprole and its degradation products were identified and quantified using UHPLC-Q-TOF/MS. Indoor culture experiments and UHPLC-Q-TOF/MS are used to study the hydrolysis, photolysis, and soil degradation behavior of ethiprole in water and soil. The differences in ethiprole degradation products across a range of environmental conditions such as pH, light, and oxygen availability were compared in o ...
DOI:
10.1016/j.watres.2019.06.004

81. Designing a Green Fluorogenic Protease Reporter by Flipping a Beta Strand of GFP for Imaging Apoptosis in Animals

Author:
Qiang Zhang; Antonino Schepis; Hai Huang; Junjiao Yang; Wen Ma; Joaquim Torra; Shao-Qing Zhang; Lina Yang; Haifan Wu; Santi Nonell; Zhiqiang Dong; Thomas B. Kornberg; Shaun R. Coughlin; Xiaokun Shu
Source:
Journal of the American Chemical Society 2019 v.141 no.11 pp. 4526-4530
ISSN:
1520-5126
Subject:
Danio rerio; Drosophila; animal development; animals; apoptosis; caspases; embryo (animal); engineering; fluorescence; image analysis; midgut; monitoring; red fluorescent protein; reporter genes
Abstract:
... A family of proteases called caspases mediate apoptosis signaling in animals. We report a GFP-based fluorogenic protease reporter, dubbed “FlipGFP”, by flipping a beta strand of the GFP. Upon protease activation and cleavage, the beta strand is restored, leading to reconstitution of the GFP and fluorescence. FlipGFP-based TEV protease reporter achieves 100-fold fluorescence change. A FlipGFP-based ...
DOI:
10.1021/jacs.8b13042
PubMed:
30821975
PubMed Central:
PMC6486793

82. Deubiquitinating Enzymes in Model Systems and Therapy: Redundancy and Compensation Have Implications

Author:
Sarah Zachariah; Douglas A. Gray
Source:
BioEssays 2019 v.41 no.11 pp. e1900112
ISSN:
0265-9247
Subject:
Danio rerio; RNA; RNA interference; gene duplication; models; mutation; phenotype; pseudogenes; surveys; therapeutics; ubiquitinyl hydrolase 1; vertebrates
Abstract:
... The multiplicity of deubiquitinating enzymes (DUBs) encoded by vertebrate genomes is partly attributable to whole genome duplication events that occurred early in chordate evolution. By surveying the literature for the largest family of DUBs (the ubiquitin‐specific proteases), extensive functional redundancy for duplicated genes has been confirmed as opposed to singletons. Dramatically conflicting ...
DOI:
10.1002/bies.201900112

83. Development of triflumizole ionic liquids containing anions of natural origin for improving the utilization and minimizing the adverse impacts on aquatic ecosystems

Author:
Gang Tang; Wenbing Zhang; Jingyue Tang; Junfan Niu; Jiale Yang; Rong Tang; Hongqiang Dong; You Liang; Laixin Luo; Yongsong Cao
Source:
Science of the total environment 2019 v.670 pp. 606-612
ISSN:
0048-9697
Subject:
Botrytis cinerea; Danio rerio; active pharmaceutical ingredients; adults; anions; aquatic ecosystems; aquatic environment; cations; fish; fungal diseases of plants; imidazole fungicides; ionic liquids; lipophilicity; photolysis; risk; salicylic acid; surface tension; toxicity; triflumizole; ultraviolet radiation
Abstract:
... Triflumizole, a broad-spectrum systemic fungicide, has been widely used for the management of fungal diseases in plants. However, rapid photolysis and high risk to the aquatic environment limit its application. Ionic liquid (IL) forms of active pharmaceutical ingredients are innovative and promising agents that can optimize the application of the starting chemicals through the selection, or functi ...
DOI:
10.1016/j.scitotenv.2019.03.249

84. Developmental exposure to BDE-99 hinders cerebrovascular growth and disturbs vascular barrier formation in zebrafish larvae

Author:
Xiali Zhong; Jianmeng Kang; Jiahuang Qiu; Wenhan Yang; Jingwei Wu; Di Ji; Yuejin Yu; Weijian Ke; Xiongjie Shi; Yanhong Wei
Source:
Aquatic toxicology 2019 v.214 pp. 105224
ISSN:
0166-445X
Subject:
Danio rerio; adverse effects; blood vessels; brain; environmental health; genes; intercellular adhesion molecule-1; interleukin-1beta; larvae; messenger RNA; models; permeability; polybrominated diphenyl ethers; risk; tight junctions; toxicity; tumor necrosis factor-alpha; vascular endothelial growth factor receptor-2
Abstract:
... Polybrominated diphenyl ethers (PBDEs) are distributed throughout the environment. Despite a moratorium on their use, concentrations of PBDEs in the atmosphere and in residential environments remain high due to their persistence. The environmental health risks remain concerning and one of the major adverse effects is neurodevelopmental toxicity. However, the early response and effects of PBDEs exp ...
DOI:
10.1016/j.aquatox.2019.105224

85. Developmental pliability in zebrafish: An experimental enquiry of acute salinity stress on the early life of zebrafish

Author:
Tania Farhana; Farhana Haque; Fahima Binte Amin; Md. Mahiuddin Zahangir; M. Sadiqul Islam
Source:
Aquaculture reports 2019 v.14 pp. 100189
ISSN:
2352-5134
Subject:
Danio rerio; acute exposure; developmental stages; eggs; embryo (animal); embryogenesis; freshwater; hatching; salinity; salt stress; salt tolerance
Abstract:
... This experiment was conducted to know the effects of salinity stress on the early life stages of zebrafish (Danio rerio). The objectives were evaluated by varying all combinations of developmental stages of zebrafish embryos exposing to a salinity gradient. The results demonstrated that zebrafish embryos (2 to 4-cell stage) could survive to hatching at 2 ppt (hatching rate 54.5%) but lowered at 4 ...
DOI:
10.1016/j.aqrep.2019.100189

86. Developmental toxicity by thifluzamide in zebrafish (Danio rerio): Involvement of leptin

Author:
Yang Yang; Fengshou Dong; Xingang Liu; Jun Xu; Xiaohu Wu; Donghui Wang; Yongquan Zheng
Source:
Chemosphere 2019 v.221 pp. 863-869
ISSN:
0045-6535
Subject:
Danio rerio; cAMP-dependent protein kinase; cyclic AMP; developmental toxicity; genes; glucagon; growth and development; leptin; phosphorylation; signal transduction; somatotropin
Abstract:
... Although previous trials have indicated that thifluzamide induces developmental inhibition in zebrafish, understanding the distinct mechanism of thifluzamide in this process remains challenging. This study investigated the effect of thifluzamide on zebrafish development and the underlying related signaling pathway. Thifluzamide repressed glucagon (GC) levels but increased growth hormone (GH) level ...
DOI:
10.1016/j.chemosphere.2019.01.043

87. Developmental toxicity of kresoxim-methyl during zebrafish (Danio rerio) larval development

Author:
Jinhua Jiang; Lu Lv; Shenggan Wu; Xuehua An; Feidi Wang; Xinju Liu; Xueping Zhao
Source:
Chemosphere 2019 v.219 pp. 517-525
ISSN:
0045-6535
Subject:
Danio rerio; adenosine triphosphate; adults; apoptosis; aromatase; biomarkers; caspase-3; caspase-9; catalase; crops; developmental toxicity; embryo (animal); enzyme activity; estradiol; gene editing; genes; glutathione peroxidase; juveniles; kresoxim-methyl; larvae; larval development; lethal concentration 50; oxidative stress; reactive oxygen species; superoxide dismutase; thyroid hormones; transcription (genetics); vitellogenin
Abstract:
... Kresoxim-methyl (KM) is a broad spectrum strobilurin fungicide that has been used widely on crops around the world. In the present study, we aimed to investigate the toxic effects of KM using various sublethal endpoints during zebrafish (Danio rerio) larval development. Results showed that the LC₅₀ values of KM to zebrafish at multiple life stages (embryo, larvae, juvenile and adult) were 0.340, 0 ...
DOI:
10.1016/j.chemosphere.2018.12.061

88. Developmental toxicity of the fungicide ziram in zebrafish (Danio rerio)

Author:
Fangjie Cao; Christopher L. Souders; Pengfei Li; Ondrej Adamovsky; Sen Pang; Lihong Qiu; Christopher J. Martyniuk
Source:
Chemosphere 2019 v.214 pp. 303-313
ISSN:
0045-6535
Subject:
Danio rerio; death; developmental toxicity; dimethyl sulfoxide; dopamine; dopamine receptors; dose response; embryo (animal); embryogenesis; fungicides; gene expression; hatching; heart rate; larvae; lethal concentration 50; locomotion; mortality; oxidative phosphorylation; oxidative stress; oxygen consumption; solvents; stress response; ziram
Abstract:
... Ziram is a broad spectrum pesticide that belongs to the class of dimethyl-dithiocarbamate (DTC) fungicides. The objectives of this study were to assess the effects of ziram in developing zebrafish. Ziram was highly toxic to zebrafish embryos, with a 96-h LC₅₀ value of 1082.54 nM (∼0.33 mg/L). Zebrafish embryos at 6 h post-fertilization (hpf) were exposed to solvent control (0.1% DMSO), or one dose ...
DOI:
10.1016/j.chemosphere.2018.09.105

89. Dicyanoisophorone-Derived Near-Infrared Fluorescent Probe for Ultrasensitive Detection of Peroxynitrite in Living Cells and Zebrafish

Author:
Pan Jia; Dongmei Liu; Zihan Zhuang; Caiyun Liu; Zilu Li; Chen Yu; Yanan Chen; Hanchuang Zhu; Xue Zhang; Yamin Yu; Baocun Zhu; Wenlong Sheng
Source:
Industrial & engineering chemistry process design and development 2019 v.58 no.43 pp. 19778-19784
ISSN:
1520-5045
Subject:
Danio rerio; fluorescent dyes; immunomodulation; near-infrared spectroscopy; process design
Abstract:
... A growing body of evidence shows that peroxynitrite (ONOO–) is involved in a large number of diseases, signal conduction, and immunoregulation in living systems. The determination of intracellular ONOO– attracts increasing attention. In this paper, a novel dicyanoisophorone-derived borate-containing near-infrared (NIR) fluorescent probe NIR-PN for sensitive detection of ONOO– was designed. Probe N ...
DOI:
10.1021/acs.iecr.9b03854

90. Dietary chitosan-selenium nanoparticle (CTS-SeNP) enhance immunity and disease resistance in zebrafish

Author:
Ivan Fan Xia; Jacky ST. Cheung; Manhui Wu; Kwong-Sen Wong; Hang-Kin Kong; Xiao-Ting Zheng; Ka-Hing Wong; Kevin WH. Kwok
Source:
Fish & shellfish immunology 2019 v.87 pp. 449-459
ISSN:
1050-4648
Subject:
Aeromonas hydrophila; Danio rerio; aquaculture; bacteria; chitosan; concanavalin A; dietary supplements; disease resistance; fish; humans; immunomodulation; immunostimulants; intraperitoneal injection; lysozyme; nanoparticles; respiratory burst; selenium; shellfish; splenocytes; survival rate
Abstract:
... Selenium (Se) is an essential micronutrient for human and animals. It plays an important role in antioxidative stress, selenoenzymes regulation and immunomodulation. In this study, two common immunostimulants chitosan (CTS) and Se were used to synthesize nanoparticles (CTS-SeNP). Immunomodulation of CTS-SeNP were explored in wild-type zebrafish (Danio rerio). Dietary supplementation of CTS-SeNP en ...
DOI:
10.1016/j.fsi.2019.01.042

91. Dietary nucleotides can directly stimulate the immunity of zebrafish independent of the intestinal microbiota

Author:
Xiaoze Guo; Jie Li; Chao Ran; Anran Wang; Mingxu Xie; Yadong Xie; Qianwen Ding; Zhen Zhang; Yalin Yang; Ming Duan; Zhigang Zhou
Source:
Fish & shellfish immunology 2019 v.86 pp. 1064-1071
ISSN:
1050-4648
Subject:
Aeromonas hydrophila; Danio rerio; amyloid; blood serum; diet; disease resistance; fish; hepcidin; immunostimulants; innate immunity; intestinal microorganisms; intestines; kidneys; models; mucins; mucosal immunity; myeloperoxidase; nucleotides
Abstract:
... In this study, we firstly tested the effects of dietary nucleotides on the disease resistance and innate immunity of zebrafish. Further, we investigated the role of intestinal microbiota in the nucleotides-induced immunostimulatory effect by using a germ-free zebrafish model and microbiota transfer technique. Fish were fed control or nucleotides (NT)-supplemented diets (at 0.05%,0.1%, 0.15% or 0.2 ...
DOI:
10.1016/j.fsi.2018.12.058

92. Differential lethal and sublethal effects in embryonic zebrafish exposed to different sizes of silver nanoparticles

Author:
Xiaobo Liu; Eduard Dumitrescu; Ajeet Kumar; Daniel Austin; Dan Goia; Kenneth N. Wallace; Silvana Andreescu
Source:
Environmental pollution 2019 v.248 pp. 627-634
ISSN:
0269-7491
Subject:
Danio rerio; cations; death; intestines; mortality; nanosilver; nitric oxide; salts; silver; skeletal muscle; sublethal effects
Abstract:
... Various parameters can influence the toxic response to silver nanoparticles (Ag NPs), including the size and surface properties, as well as the exposure environment and the biological site of action. Herein, we assess the intestinal toxicity of three different sizes (10, 40, and 100 nm) of Ag NPs in embryonic zebrafish, and describe the relationship between the properties and behavior of Ag NPs in ...
DOI:
10.1016/j.envpol.2019.02.085

93. Distinct functions of TMC channels: a comparative overview

Author:
Xiaomin Yue; Yi Sheng; Lijun Kang; Rui Xiao
Source:
Cellular and molecular life sciences 2019 v.76 no.21 pp. 4221-4232
ISSN:
1420-682X
Subject:
Danio rerio; Drosophila; chlorides; deafness; hearing; ion channels; mammals; models; mutation; oviposition; texture; topology
Abstract:
... In the past two decades, transmembrane channel-like (TMC) proteins have attracted a significant amount of research interest, because mutations of Tmc1 lead to hereditary deafness. As evolutionarily conserved membrane proteins, TMC proteins are widely involved in diverse sensorimotor functions of many species, such as hearing, chemosensation, egg laying, and food texture detection. Interestingly, r ...
DOI:
10.1007/s00018-019-03214-1

94. Diverse effects of nitric oxide reductase NorV on Aeromonas hydrophila virulence-associated traits under aerobic and anaerobic conditions

Author:
Jin Liu; Yuhao Dong; Nannan Wang; Shuiyan Ma; Chengping Lu; Yongjie Liu
Source:
Veterinary research 2019 v.50 no.1 pp. 67
ISSN:
1297-9716
Subject:
Aeromonas hydrophila; Danio rerio; Tetrahymena thermophila; aerobic conditions; anaerobic conditions; coculture; cytotoxicity; dose response; enzyme activity; enzymes; gene deletion; gene expression regulation; genes; growth retardation; hemolysins; macrophages; mutants; nitric oxide; pathogenesis; predation; protists; secretion; virulence
Abstract:
... NorV has been known to be an anaerobic nitric oxide reductase associated with nitric oxide (NO) detoxification. Recently, we showed that the norV gene of Aeromonas hydrophila was highly upregulated after co-culturing with Tetrahymena thermophila. Here, we demonstrated that the transcription and expression levels of norV were upregulated in a dose-dependent manner after exposure to NO under aerobic ...
DOI:
10.1186/s13567-019-0683-6
PubMed:
31547881
PubMed Central:
PMC6755692

95. Dnd shRNA constructs cause altered PGC migration but fail to sterilize

Author:
Sandra Noble; Susan Boratynska; Vishal Saxena; Robert H. Devlin; Marc Ekker
Source:
Aquaculture 2019 v.512 pp. 734305
ISSN:
0044-8486
Subject:
Danio rerio; Drosophila melanogaster; RNA interference; adults; aquaculture; biocontainment; ecosystems; embryo (animal); gene expression; genes; germ cells; microRNA; reproduction; risk; small interfering RNA; sterilizing; transgenic animals; viability; wild fish
Abstract:
... The release or escape of genetically modified fish from confined aquaculture facilities presents a potential risk to wild fish stocks and surrounding ecosystems. Thus, reliable biocontainment methods for aquaculture-relevant species are needed. Since physical barriers are not 100% effective, it is critical to develop reliable genetic-based methods for biocontainment. RNA interference (RNAi) could ...
DOI:
10.1016/j.aquaculture.2019.734305

96. Dydrogesterone affects the transcription of genes in GnRH and steroidogenesis pathways and increases the frequency of atretic follicles in zebrafish (Danio rerio)

Author:
Wen-Jun Shi; Li-Xin Hu; Guo-Yong Huang; You-Sheng Liu; Jin-Na Zhang; Lingtian Xie; Guang-Guo Ying
Source:
Chemosphere 2019 v.216 pp. 725-732
ISSN:
0045-6535
Subject:
Danio rerio; adults; animal ovaries; aquatic environment; aquatic organisms; brain; females; follicular atresia; gene expression regulation; genes; gonadotropin-releasing hormone; histology; histopathology; humans; males; messenger RNA; quantitative polymerase chain reaction; steroidogenesis; testes; transcription (genetics); veterinary medicine
Abstract:
... Dydrogesterone (DDG) is a synthetic progestin broadly used in human and veterinary medicine and has been widely detected in aquatic environments. However, its potential effects on aquatic organisms are little documented. Here we investigate the short-term effects of DDG on the transcriptional and histological responses in adult zebrafish (Danio rerio). Adult zebrafish were exposed to 32.0, 305 and ...
DOI:
10.1016/j.chemosphere.2018.10.202

97. Dydrogesterone exposure induces zebrafish ovulation but leads to oocytes over-ripening: An integrated histological and metabolomics study

Author:
Yu-Xia Jiang; Wen-Jun Shi; Dong-Dong Ma; Jin-Na Zhang; Guang-Guo Ying; Hui Zhang; Choon-Nam Ong
Source:
Environment international 2019 v.128 pp. 390-398
ISSN:
0160-4120
Subject:
Danio rerio; animal ovaries; arachidonic acid; biochemical pathways; biodegradation; embryo (animal); female genital diseases; females; fish; follicular atresia; free amino acids; free fatty acids; histology; males; metabolome; metabolomics; oocytes; ovulation; phospholipids; prostaglandin synthase; prostaglandins; proteins; putrescine; sex ratio; sexual maturity; spawning; spermatids; spermatogenesis; spermatozoa; testes; urea
Abstract:
... Dydrogesterone (DDG) is a synthetic progestin widely used in numerous gynecological diseases. DDG has been shown to disturb fish reproduction, however, the mechanism is still unclear. Here we studied the histological changes and differences of metabolome between exposed and control fish gonads after exposure of zebrafish (Danio rerio) embryos to 2.8, 27.6, and 289.8 ng/L DDG until sexual maturity ...
DOI:
10.1016/j.envint.2019.04.059

98. Early development of primordial germ cells in Pacific bluefin tuna Thunnus orientalis

Author:
Kentaro Higuchi; Rie Goto; Junpei Konishi; Yoshiaki Ina; Yukinori Kazeto; Koichiro Gen
Source:
Theriogenology 2019 v.131 pp. 106-112
ISSN:
0093-691X
Subject:
3' untranslated regions; Danio rerio; Thunnus orientalis; aquaculture; biotechnology; early development; eggs; embryogenesis; fluorescent proteins; genes; germ cells; gonads; hatching; histology; larvae; migratory behavior; somatic cells; transcription (genetics)
Abstract:
... Bluefin tuna is one of the most important aquaculture species in several countries; however, information regarding the primordial germ cell (PGC) development and migration in this species is scarce. This information is vital for application in reproductive biotechnology, for example, induced sterility through targeted cell ablation or PGC manipulation. Teleost PGC can be visualized by injecting an ...
DOI:
10.1016/j.theriogenology.2019.03.031

99. Ecofriendly one pot fabrication of methyl gallate@ZIF-L nanoscale hybrid as pH responsive drug delivery system for lung cancer therapy

Author:
Prabhu R.; Mohamed Asik R.; Anjali R.; Archunan G.; Prabhu N.M.; Pugazhendhi A.; Suganthy N.
Source:
Process biochemistry 2019 v.84 pp. 39-52
ISSN:
1359-5113
Subject:
Danio rerio; Gracilaria; apoptosis; biocompatibility; cell lines; cytochrome c; cytotoxicity; drug delivery systems; drugs; embryo (animal); encapsulation; fluorescence; imidazole; lung neoplasms; methyl gallate; mitochondria; models; mononuclear leukocytes; nanocomposites; nanomaterials; neoplasm cells; pH; porosity; reactive oxygen species; spectroscopy; toxicity testing
Abstract:
... Zeolitic imidazole frame work, a special class of porous crystalline material with tunable pore size has emerged as a promising candidate for biomedical applications. The present work enlightens the fabrication of methyl gallate encapsulated ZIF-L (MG@ZIF-L) by utilizing red seaweed Gracilaria debilis and evaluating its anticancer potential against lung cancer cell lines A549. The material structu ...
DOI:
10.1016/j.procbio.2019.06.015

100. Effect of Propiconazole on the Lipid Metabolism of Zebrafish Embryos (Danio rerio)

Author:
Miaomiao Teng; Feng Zhao; Yimeng Zhou; Sen Yan; Sinuo Tian; Jin Yan; Zhiyuan Meng; Sheng Bi; Chengju Wang
Source:
Journal of agricultural and food chemistry 2019 v.67 no.16 pp. 4623-4631
ISSN:
1520-5118
Subject:
Danio rerio; aquatic ecosystems; aquatic environment; cholesterol; embryo (animal); enzyme activity; fatty acids; fatty-acid synthase; fish; gas chromatography-mass spectrometry; gene expression regulation; genes; larvae; laws and regulations; lipid metabolism; lipoprotein lipase; locomotion; propiconazole; tandem mass spectrometry; triazoles
Abstract:
... Propiconazole is a triazole fungicide that has been widely used in agriculture and has been detected in the aquatic environment. This study aimed to investigate the effects of propiconazole exposure on lipid metabolism in the early life stages of zebrafish for 120 h postfertilization (hpf). Using the early life stages of zebrafish to address scientific questions is lower in cost, more efficient, a ...
DOI:
10.1021/acs.jafc.9b00449