U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Publication Year 2019 Remove constraint Publication Year: 2019 Subject term acylation Remove constraint Subject term: acylation
Start Over

Search

131  Search Results

« Previous | 1 - 20 of 131 |
Number of results to display per page

Search Results

1. The 3′ Untranslated Region of a Plant Viral RNA Directs Efficient Cap-Independent Translation in Plant and Mammalian Systems

Author:
Jelena J. Kraft; Mariko S. Peterson; Sung Ki Cho; Zhaohui Wang; Alice Hui; Aurélie M. Rakotondrafara; Krzysztof Treder; Cathy L. Miller; W. Allen Miller
Source:
Pathogens 2019 v.8 no.1 pp. -
ISSN:
2076-0817
Subject:
Panicum; Paspalum; acylation; genome; guanosine; human cell lines; humans; messenger RNA; oats; plant viruses; plants (botany); rabbits; translation (genetics); viruses; wheat; wheat germ
Abstract:
... Many plant viral RNA genomes lack a 5′ cap, and instead are translated via a cap-independent translation element (CITE) in the 3′ untranslated region (UTR). The panicum mosaic virus-like CITE (PTE), found in many plant viral RNAs, binds and requires the cap-binding translation initiation factor eIF4E to facilitate translation. eIF4E is structurally conserved between plants and animals, ...
DOI:
10.3390/pathogens8010028
PubMed:
30823456
PubMed Central:
PMC6471432

2. Acylation of Alkenes with the Aid of AlCl₃ and 2,6-Dibromopyridine

Author:
Shinya Tanaka; Tsukasa Kunisawa; Yuji Yoshii; Tetsutaro Hattori
Source:
Organic letters 2019 v.21 no.21 pp. 8509-8513
ISSN:
1523-7052
Subject:
acylation; alkenes; aluminum chloride; chemical structure; hydrogen; organochlorine compounds; pyridines
Abstract:
... Friedel–Crafts-type acylation of alkenes with acyl chlorides has been successfully conducted with a wide substrate scope by the combined use of AlCl₃ and 2,6-dibromopyridine. Trisubstituted alkenes afford allylketones or vinylketones depending on the presence or absence of hydrogen atom(s) at the β-position to the acylation site, while monosubstituted alkenes exclusively afford vinylketones. ...
DOI:
10.1021/acs.orglett.9b02688

3. Acylsugar diversity in the resin glycosides from Ipomoea tricolor seeds as chemosensitizers in breast cancer cells

Author:
Jhon Castañeda-Gómez; Pedro Lavias-Hernández; Mabel Fragoso-Serrano; Argelia Lorence; Rogelio Pereda-Miranda
Source:
Phytochemistry letters 2019 v.32 pp. 77-82
ISSN:
1874-3900
Subject:
Ipomoea tricolor; acylation; breast neoplasms; esterification; glycosides; high performance liquid chromatography; humans; ions; mass spectrometry; moieties; multiple drug resistance; neoplasm cells; nuclear magnetic resonance spectroscopy; ornamental plants; seeds; sodium; sugars; vinblastine
Abstract:
... Mexican morning glory, Ipomoea tricolor Cav., is native to America and widely cultivated as an ornamental plant. High performance liquid chromatography profiling coupled with off-line electrospray mass spectrometry detection was applied to identify novel acylsugar from the CHCl3-soluble resin glycoside from seeds. Dereplication of known tricolorins A-J included the recording of mass values for ion ...
DOI:
10.1016/j.phytol.2019.05.004

4. An Aliphatic Bischler–Napieralski Reaction: Dihydropyridones by Cyclocarbonylation of 3-Allylimidazolidin-4-ones

Author:
Mostafa M. Amer; Olatz Olaizola; Jennifer Carter; Hossay Abas; Jonathan Clayden
Source:
Organic letters 2019 v.22 no.1 pp. 253-256
ISSN:
1523-7052
Subject:
acylation; alanine; enantiomers; hydrolysis; moieties; organochlorine compounds; pipecolic acid; potassium iodide
Abstract:
... The N-chloroformylimidazolidinone derivative of enantiopure l-alanine was deprotonated to form an enolate and functionalized with a series of allylic halides. Treatment of the resulting carbamoyl chlorides with potassium iodide led to cyclization of the allylic substituent onto the carbonyl group in an intramolecular aliphatic Friedel–Crafts-type acylation that corresponds to an aliphatic Bischler ...
DOI:
10.1021/acs.orglett.9b04250

5. Antioxidant capacity and hepatoprotective activity of myristic acid acylated derivative of phloridzin

Author:
Chunli Liu; Chunlong Yuan; Hosahalli S. Ramaswamy; Yamei Ren; Xiaolin Ren
Source:
Heliyon 2019 v.5 no.5 pp. e01761
ISSN:
2405-8440
Subject:
2,2-diphenyl-1-picrylhydrazyl; acylation; antioxidant activity; antioxidants; blood serum; carbon tetrachloride; glutathione; hepatoprotective effect; hepatotoxicity; interleukin-6; liver; liver diseases; liver regeneration; malondialdehyde; moieties; myristic acid; phloridzin
Abstract:
... The antioxidant activities in vitro and hepatoprotective effects against carbon tetrachloride (CCl₄) induced acute liver injury in vivo of myristic acid acylated derivative of phloridzin (PZM) were investigated. The PZM was obtained by enzymatic acylation of myristic acid and phloridzin (PZ). The antioxidant capability of PZM in vitro was evaluated by the ferric reducing antioxidant power assay (F ...
DOI:
10.1016/j.heliyon.2019.e01761
PubMed:
31193831
PubMed Central:
PMC6543077

6. Atropselective Synthesis of N,C-Bis(diphenylphosphanes) from Bridged 2-Arylindoles Based on Effective Point-to-Axial Asymmetric Inductions after an Unusual Dilithiation⊥

Author:
Felix Bäuerle; Reinhard Brückner
Source:
Organic letters 2019 v.21 no.24 pp. 9970-9975
ISSN:
1523-7052
Subject:
acylation; anhydrides; carboxylic acids; diastereomers; indoles; lactones; methanolysis; stereospecificity
Abstract:
... An asymmetric methanolysis of glutaric anhydride and 6 ensuing steps gave veratrol-annulated dimethylcyclo-heptenone diastereomers with 99% ee; ring closures occurred by Friedel–Crafts acylations of carboxylic acids obtained by stereospecific hydrogenolyses of a pair of diastereomeric δ-lactones. The mentioned cycloheptenones and Ph−NH−NH₂ underwent Fischer indole syntheses providing the tetracycl ...
DOI:
10.1021/acs.orglett.9b03896

7. Avermectin loaded nanosphere prepared from acylated alkali lignin showed anti-photolysis property and controlled release performance

Author:
Mingsong Zhou; Dongping Wang; Dongjie Yang; Xueqing Qiu; Yingxin Li
Source:
Industrial crops and products 2019 v.137 pp. 453-459
ISSN:
0926-6690
Subject:
acylation; avermectins; encapsulation; hydrophobicity; lignin; nanospheres; organochlorine compounds; pesticides; photosensitivity; ultraviolet radiation
Abstract:
... Acetylated lignin (ACAL) and benzoylated lignin (BZAL) were obtained from the chemical modification of alkali lignin with acetyl chloride and benzoyl chloride, respectively. The results showed that the introduction of alkyl chain can increase the hydrophobicity of AL evidently. The ACAL and BZAL were used as shell materials for the preparation of nanospheres to encapsulate photosensitive pesticide ...
DOI:
10.1016/j.indcrop.2019.04.037

8. Base-Mediated One-pot Synthesis of Oxygen-Based Heterocycles from 2-Hydroxyphenyl-Substituted para-Quinone Methides

Author:
Gurdeep Singh; Suresh Kumar; Arjun Chowdhury; Ramasamy Vijaya Anand
Source:
Journal of organic chemistry 2019 v.84 no.24 pp. 15978-15989
ISSN:
1520-6904
Subject:
acylation; alkylation; chemical structure; coumarin; furans; organic chemistry; oxidation; quinones; synthesis
Abstract:
... One-pot synthesis of oxygen-containing heterocycles has been achieved through alkylation/acylation of 2-hydroxyphenyl-substituted para-quinone methides followed by an intramolecular 1,6-conjugate addition/cyclization and oxidation sequence. This protocol provides access to a wide range of oxygen-based heterocycles, such as 2,3-disubstituted benzo[b]furans, 2,3-dihydrobenzofurans and diaryl-substit ...
DOI:
10.1021/acs.joc.9b02455

9. Binary mixtures of ionic liquids-DMSO as solvents for the dissolution and derivatization of cellulose: Effects of alkyl and alkoxy side chains

Author:
Daniela C. Ferreira; Mayara L. Oliveira; Thais A. Bioni; Haq Nawaz; Alistair W.T. King; Ilkka Kilpeläinen; Michael Hummel; Herbert Sixta; Omar A. El Seoud
Source:
Carbohydrate polymers 2019 v.212 pp. 206-214
ISSN:
0144-8617
Subject:
acetates; acylation; biopolymers; cellobiose; cellulose; derivatization; dimethyl sulfoxide; hydrogen bonding; imidazoles; ionic liquids; nuclear magnetic resonance spectroscopy; oxygen; rheology
Abstract:
... The efficiency of mixtures of ionic liquids (ILs) and molecular solvents in cellulose dissolution and derivatization depends on the structures of both components. We investigated the ILs 1-(1-butyl)-3-methylimidazolium acetate (C4MeImAc) and 1-(2-methoxyethyl)-3-methylimidazolium acetate (C3OMeImAc) and their solutions in dimethyl sulfoxide, DMSO, to assess the effect of presence of an ether linka ...
DOI:
10.1016/j.carbpol.2019.02.024

10. Bioactive compounds from the seeds of Amomum tsaoko Crevost et Lemaire, a Chinese spice as inhibitors of sphingosine kinases, SPHK1/2

Author:
Seulah Lee; Joo Chan Lee; Lalita Subedi; Kyo Hee Cho; Sun Yeou Kim; Hyun-Ju Park; Ki Hyun Kim
Source:
RSC advances 2019 v.9 no.58 pp. 33957-33968
ISSN:
2046-2069
Subject:
Amomum tsao-ko; Oriental traditional medicine; acylation; bioactive compounds; bioactive properties; enantioselectivity; enzyme activity; ethanol; fatty acids; models; nuclear magnetic resonance spectroscopy; phenolic compounds; phosphotransferases (kinases); seeds; spectral analysis; sphingosine; spices; terpenoids
Abstract:
... Amomum tsaoko Crevost et Lemaire (Zingiberaceae), a traditional Chinese spice also known as “Caoguo” or “tsao-ko,” has been considered to have many health benefits. As part of our continuous efforts to screen natural resources exhibiting potential bioactivity, we examined the seeds of A. tsaoko and found that its EtOH extract inhibited sphingosine kinases 1 and 2 (SPHK1/2). Bioactivity-based analy ...
DOI:
10.1039/c9ra07988b

11. Biocatalytic Synthesis of Lipophilic Baicalin Derivatives as Antimicrobial Agents

Author:
Xuan Xin; Mengmeng Zhang; Xiao-Feng Li; Guanglei Zhao
Source:
Journal of agricultural and food chemistry 2019 v.67 no.42 pp. 11684-11693
ISSN:
1520-5118
Subject:
acylation; anti-infective agents; antimicrobial properties; baicalin; catalytic activity; esterification; fatty acids; fatty alcohols; glycosides; lipophilicity; moieties
Abstract:
... Enzymatic acylation is commonly used to increase the lipophilicity of flavonoids. However, the absence of primary hydroxyl groups makes it challenging to acylate baicalin using traditional acylation methods. In this study, an enzymatic esterification strategy was developed to introduce fatty-acid chains into baicalin at its carboxyl group, hence successfully synthesizing a new series of baicalin e ...
DOI:
10.1021/acs.jafc.9b04667

12. Biodegradation mechanism of polyesters by hydrolase from Rhodopseudomonas palustris: An in silico approach

Author:
Xiaodan Wang; Jinfeng Chen; Xiaowen Tang; Junjie Wang; Ledong Zhu; Weixin Zhang; Hui Wang; Yanwei Li; Qingzhu Zhang
Source:
Chemosphere 2019 v.231 pp. 126-133
ISSN:
0045-6535
Subject:
Rhodopseudomonas palustris; acetates; active sites; acylation; amino acids; biodegradation; catalytic activity; formates; hydrolases; hydrolysis; molecular dynamics; mutation; physicochemical properties; plastics; polyesters; polylactic acid; quantum mechanics; simulation models; surface area
Abstract:
... Massively used plastics have caused worldwide environmental concerns. Polyesters like polylactic acid (PLA) are one of the mostly used plastics due to its excellent physical and chemical properties and low-cost advantages. It is critical to develop the elimination and recycle techniques for polyesters. Experimental studies have shown that a hydrolase RPA1511 isolated from Rhodopseudomonas palustri ...
DOI:
10.1016/j.chemosphere.2019.05.112

13. Boron trifluoride etherate promoted microwave-assisted synthesis of antimalarial acridones

Author:
Papireddy Kancharla; Rozalia A. Dodean; Yuexin Li; Jane X. Kelly
Source:
RSC advances 2019 v.9 no.72 pp. 42284-42293
ISSN:
2046-2069
Subject:
acylation; antimalarials; boron; microwave treatment; multiple drug resistance; parasites
Abstract:
... A microwave-assisted, rapid and efficient method using boron trifluoride etherate (BF₃.Et₂O) for the synthesis of acridones, via an intramolecular acylation of N-phenylanthranilic acid derivatives, has been developed. The reaction proceeds under solvent-free conditions, tolerates a wide range of functional groups, and provides rapid access to a range of acridones in good to excellent yields. Sever ...
DOI:
10.1039/c9ra09478d

14. Both the mono- and di-anions of ellagic acid are effective inhibitors of the serine β-lactamase CTX-M-15

Author:
Nathan Talbot; Nicholas T. Powles; Michael I. Page
Source:
RSC advances 2019 v.9 no.53 pp. 30637-30640
ISSN:
2046-2069
Subject:
active sites; acylation; anions; beta-lactamase; ellagic acid; enzyme inhibitors; lactones; serine
Abstract:
... Ellagic acid, a δ-lactone with ionisable phenolic residues, is an efficient time-dependent inhibitor of the serine β-lactamase enzyme CTX-M-15. The pH-dependence of the rate of inhibition shows that both the mono- and di-anionic species of ellagic acid are effective inhibitors, both with second order rate constants of ∼1.5 × 10⁴ M⁻¹ s⁻¹. The structurally similar δ-lactone urolithin A, which lacks ...
DOI:
10.1039/c9ra05835d

15. Carrot anthocyanins: nutrition, diversity and genetics

Author:
P. F. Cavagnaro; F. Bannoud; M. lorizzo; D. Senalik; S. L. Ellison; P. W. Simon
Source:
Acta horticulturae 2019 v. no.1264 pp. 101-106
ISSN:
0567-7572
Subject:
acylation; anthocyanins; anti-inflammatory activity; antioxidants; biosynthesis; breeding programs; carrots; chemical structure; dietary supplements; food colorants; germplasm; glycosylation; health promotion; new variety; phytonutrients; pigmentation; plant breeding; tissues; water solubility
Abstract:
... Purple carrots represent an excellent dietary source of anthocyanins. The consumption of these water-soluble flavonoid pigments is associated with various health benefits, attributed mainly to their antioxidant and anti-inflammatory properties. Anthocyanin pigmentation varies broadly among organs and tissues of the carrot plant and among carrot genetic stocks. The chemical structure of anthocyanin ...
DOI:
10.17660/ActaHortic.2019.1264.11

16. Catalytic Activation of Cis-Vicinal Diols by Boronic Acids: Site-Selective Acylation of Carbohydrates

Author:
Naoyuki Shimada; Yuki Nakamura; Takayuki Ochiai; Kazuishi Makino
Source:
Organic letters 2019 v.21 no.10 pp. 3789-3794
ISSN:
1523-7052
Subject:
Lewis bases; acylation; boronic acids; carbohydrates; catalysts; catalytic activity; glycols; moieties
Abstract:
... Site-selective acylation of unprotected carbohydrates by using stable, storable, and easily handled imidazole-containing organoboronic acid catalysts is described. This catalytic process with low catalyst loading enables the introduction of a wide variety of acyl functional groups into the equatorial position of cis-vicinal diols in unprotected hexapyranosides with excellent site selectivity. This ...
DOI:
10.1021/acs.orglett.9b01231

17. Chemoenzymatic Synthesis of a Chiral Ozanimod Key Intermediate Starting from Naphthalene as Cheap Petrochemical Feedstock

Author:
Florian Uthoff; Jana Löwe; Christina Harms; Kai Donsbach; Harald Gröger
Source:
Journal of organic chemistry 2019 v.84 no.8 pp. 4856-4866
ISSN:
1520-6904
Subject:
active pharmaceutical ingredients; acylation; amination; carboxylic ester hydrolases; chemical bonding; chemical reduction; chemical structure; drugs; feedstocks; manufacturing; naphthalene; optical isomerism; organic chemistry; sclerosis
Abstract:
... Ozanimod represents a recently developed, promising active pharmaceutical ingredient (API) molecule in combating multiple sclerosis. Addressing the goal of a scalable, economically attractive, and technically feasible process for the manufacture of this drug, a novel alternative synthetic approach toward (S)-4-cyano-1-aminoindane as a chiral key intermediate for ozanimod has been developed. The to ...
DOI:
10.1021/acs.joc.8b03290

18. Chemoenzymatic synthesis of hydroxytyrosol monoesters and their suppression effect on nitric oxide production stimulated by lipopolysaccharides

Author:
Ayaka Sakakura; Martin Pauze; Atsuhiro Namiki; Megumi Funakoshi-Tago; Hiroomi Tamura; Kengo Hanaya; Shuhei Higashibayashi; Takeshi Sugai
Source:
Bioscience, biotechnology, and biochemistry 2019 v.83 no.2 pp. 185-191
ISSN:
1347-6947
Subject:
Pseudozyma antarctica; acylation; biotechnology; butyrates; carboxylic ester hydrolases; chemoselectivity; fatty acids; hydroxylation; lipopolysaccharides; nitric oxide
Abstract:
... Fatty acid monoesters of hydroxytyrosol [2-(3,4-dihydroxyphenyl)ethanol] were synthesized in two steps from tyrosol (4-hydroxyphenylethanol) by successive Candida antarctica lipase B-catalyzed chemoselective acylation on the primary aliphatic hydroxy group over phenolic hydroxy group in tyrosol, and 2-iodoxybenzoic acid (IBX)-mediated hydroxylation adjacent to the remaining free phenolic hydroxy g ...
DOI:
10.1080/09168451.2018.1530970

19. Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6

Author:
Eric S. Okerberg; Kevin B. Dagbay; Jennifer L. Green; Ishankumar Soni; Arwin Aban; Tyzoon K. Nomanbhoy; Sergey N. Savinov; Jeanne A. Hardy; John W. Kozarich
Source:
Biochemistry 2019 v.58 no.52 pp. 5320-5328
ISSN:
1520-4995
Subject:
acylation; adenine; binding sites; caspase-6; in vitro studies; ligands; moieties; mutation; nucleotides; phosphates; proteins; proteolysis
Abstract:
... Acyl phosphates of ATP (ATPAc) and related nucleotides have proven to be useful for the interrogation of known nucleotide binding sites via specific acylation of conserved lysines (K). In addition, occasional K acylations are identified in proteins without such known sites. Here we present a robust and specific acylation of procaspase-6 by ATPAc at K133 in Jurkat cell lysates. The K133 acylation i ...
DOI:
10.1021/acs.biochem.9b00290
PubMed:
31095371
PubMed Central:
PMC6874883

20. Continuous Flow Synthesis of Isoxazoles via Vinyl Azides from Friedel–Crafts Acylation of Alkynes: A Modulated Troubleshooting Optimization Approach

Author:
Hyungmo Koo; Hun Young Kim; Kyungsoo Oh
Source:
Organic letters 2019 v.21 no.24 pp. 10063-10068
ISSN:
1523-7052
Subject:
acylation; alkynes; azides; chemical structure; ketones
Abstract:
... The synthesis of isoxazoles has been achieved in a continuous flow system composed of two reaction units: the Friedel–Crafts acylation of alkynes and the azide conjugate addition to the resulting β-chlorovinyl ketones followed by a photochemical–thermal reaction sequence. The salient feature of the current flow system includes the safe handling of potentially explosive organic azide species as wel ...
DOI:
10.1021/acs.orglett.9b04010