U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Publication Year 2019 Remove constraint Publication Year: 2019 Subject term antineoplastic activity Remove constraint Subject term: antineoplastic activity
Start Over

Search

1,397  Search Results

« Previous | 1 - 20 of 1,397 |
Number of results to display per page

Search Results

1. 16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity in vivo and in vitro

Author:
Yiren Yang; Liping Long; Xinxin Zhang; Kairu Song; Da Wang; Xin Xiong; Huiyuan Gao; Luping Sha
Source:
RSC advances 2019 v.9 no.54 pp. 31758-31772
ISSN:
2046-2069
Subject:
antineoplastic activity; apoptosis; breasts; doxorubicin; glycosides; hemolysis; human cell lines; humans; hydrolysates; lungs; metastasis; mice; neoplasm cells; neoplasm progression; toxicity; triterpenoids; uterine cervical neoplasms
Abstract:
... Barrigenol-like triterpenoids (BATs) showed promising anti-tumor, anti-inflammatory and anti-Alzheimer's activities, while, the inhibitory strength was usually affected by their states with aglycones or glycosides. In order to find more BATs as new anti-tumor agents with much more efficiency, the chemical and pharmaceutical studies were carried out on the acid hydrolysate product (AHP) of Semen Ae ...
DOI:
10.1039/c9ra06015d

2. 1‐O‐alkylglycerols from the hepatopancreas of the crab Paralithodes camtschaticus, liver of the squid Berryteuthis magister, and liver of the skate Bathyraja parmifera, and their anticancer activity on human melanoma cells

Author:
Nikolay A. Latyshev; Svetlana P. Ermakova; Ekaterina V. Ermolenko; Andrey B. Imbs; Sergey P. Kasyanov; Ruslan M. Sultanov
Source:
Journal of food biochemistry 2019 v.43 no.5 pp. e12828
ISSN:
0145-8884
Subject:
Bathyraja; Paralithodes camtschatica; antineoplastic activity; aquatic organisms; crabs; cytotoxicity; hepatopancreas; human cell lines; inhibitory concentration 50; lipids; liver; melanoma; squid; therapeutics
Abstract:
... 1‐O‐alkylglycerols (AKG) are a class of natural ether lipids derived from 1‐O‐alkyl‐2,3‐diacyl‐sn‐glycerols by deacylation. In this study, 1‐O‐alkylglycerol (AKG) composition was investigated in the hepatopancreas lipids of the crab Paralithodes camtschaticus and the liver lipids of the squid Berryteuthis magister and the skate Bathyraja parmifera. One of the principal AKG in marine organisms was ...
DOI:
10.1111/jfbc.12828

3. 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells

Author:
Wuguo Li; Qing Zhang; Kaotan Chen; Zhenhua Sima; Jingli Liu; Qiang Yu; Jiawei Liu
Source:
BMC complementary and alternative medicine 2019 v.19 no.1 pp. 38
ISSN:
1472-6882
Subject:
Reynoutria japonica; Western blotting; alternative medicine; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle; cell growth; cell viability; chemical structure; dose response; drug resistance; ethyl acetate; flow cytometry; gels; hepatoma; high performance liquid chromatography; humans; inhibitory concentration 50; juglone; luciferase; metastasis; nuclear magnetic resonance spectroscopy; oncogenes; phosphorylation; physicochemical properties; relapse; reporter genes; roots; signal transduction; spectral analysis; stem cells; transactivators; transcription (genetics); tyrosine
Abstract:
... BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is an oncogene constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells (CSCs). Constitutively activated STAT3 plays a pivotal role in holding cancer stemness of HCC CSCs, which are essential for hepatoma initiation, relapse, metastasis and drug resistance. Therefore, STAT3 has been validated a ...
DOI:
10.1186/s12906-019-2440-9
PubMed:
30709346
PubMed Central:
PMC6359800

4. 3‐Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau

Author:
Young H. Ko; Katarzyna Niedźwiecka; Margarida Casal; Peter L. Pedersen; Stanisław Ułaszewski
Source:
Yeast 2019 v.36 no.4 pp. 211-221
ISSN:
0749-503X
Subject:
Cryptococcus neoformans; adenosine triphosphate; adverse effects; algae; animal models; antimicrobial properties; antineoplastic activity; apoptosis; bromination; cancer therapy; cell movement; fungi; glucose; glycolysis; hexokinase; lactic acid; mitochondria; neoplasm cells; neoplasms; oxygen; patients; pumps; pyruvic acid; transporters
Abstract:
... 3‐Bromopyruvate (3BP) is a small, highly reactive molecule formed by bromination of pyruvate. In the year 2000, the antitumor properties of 3BP were discovered. Studies using animal models proved its high efficacy for anticancer therapy with no apparent side effects. This was also found to be the case in a limited number of cancer patients treated with 3BP. Due to the “Warburg effect,” most tumor ...
DOI:
10.1002/yea.3367

5. 4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer

Author:
Zhicong Zhao; Dongsheng Shang; Lipeng Qiu; Chang Guo; Yanyan Li; Hanqing Liu; Guoyue Yuan; Zhigang Tu
Source:
Life sciences 2019 v.238 pp. 116973
ISSN:
0024-3205
Subject:
DNA damage; antineoplastic activity; antineoplastic agents; cell senescence; drug therapy; enzymes; fluorescent antibody technique; heterocyclic nitrogen compounds; in vitro studies; in vivo studies; mice; screening; signal transduction; staining; stomach neoplasms; survival rate
Abstract:
... Gastric cancer (GC) is a common cancer with a relatively low survival rate. Cellular senescence, a potent anti-cancer mechanism, is naturally occurred, and can be induced by chemotherapeutic agents. We sought to explore new compounds against GC cells by inducing cellular senescence.Primary screening of a library of N-heterocyclic compounds identified some with potent inhibitory effects on GC cells ...
DOI:
10.1016/j.lfs.2019.116973

6. 7-O-geranylquercetin contributes to reverse P-gp-mediated adriamycin resistance in breast cancer

Author:
Enxia Zhang; Jiasi Liu; Lei Shi; Xin Guo; Ze Liang; Jiaxin Zuo; Hong Xu; Huaxin Wang; Xiaohong Shu; Shanshan Huang; Shubiao Zhang; Xiaohui Kang; Yuhong Zhen
Source:
Life sciences 2019 v.238 pp. 116938
ISSN:
0024-3205
Subject:
P-glycoproteins; Western blotting; antineoplastic activity; breast neoplasms; caudal vein; computer simulation; doxorubicin; drug resistance; drug therapy; flow cytometry; fluorescence microscopes; fluorescence microscopy; gene expression regulation; genes; mice; molecular models; quantitative polymerase chain reaction; quercetin; rhodamines; tissues; toxicity testing; viability
Abstract:
... To investigate the effect of 7-O-geranylquercetin (GQ), a derivative of quercetin (Q), on reversing drug resistance in breast cancer MCF-7/ADR cells and reveal the mechanisms related to P-glycoprotein (P-gp).Cell viability was determined by MTT assay. Accumulation of adriamycin (ADR) in cells was determined by confocal fluorescence microscope and microplate reader while that of rhodamine (Rh) was ...
DOI:
10.1016/j.lfs.2019.116938

7. Berberis Plants—Drifting from Farm to Food Applications, Phytotherapy, and Phytopharmacology

Author:
Bahare Salehi; Zeliha Selamoglu; Bilge Sener; Mehtap Kilic; Arun Kumar Jugran; Nunziatina de Tommasi; Chiara Sinisgalli; Luigi Milella; Jovana Rajkovic; Maria Flaviana B. Morais-Braga; Camila F. Bezerra; Janaína E. Rocha; Henrique D.M. Coutinho; Adedayo Oluwaseun Ademiluyi; Zabta Khan Shinwari; Sohail Ahmad Jan; Ebru Erol; Zulfiqar Ali; Elise Adrian Ostrander; Javad Sharifi-Rad; María de la Luz Cádiz-Gurrea; Yasaman Taheri; Miquel Martorell; Antonio Segura-Carretero; William C. Cho
Source:
Foods 2019 v.8 no.10 pp. -
ISSN:
2304-8158
Subject:
Berberis; alkaloids; antimicrobial properties; antineoplastic activity; antioxidants; bioactive compounds; chemical constituents of plants; diabetes; essential oils; farms; flavorings; food industry; food preservation; fruit juices; fruits; gas chromatography; leaves; limonene; neoplasms; ocimene; oleanolic acid; p-cymene; pharmaceutical industry; phytotherapy; tannins; toxicity; Europe; Iran; Pakistan; United States
Abstract:
... The genus Berberis includes about 500 different species and commonly grown in Europe, the United States, South Asia, and some northern areas of Iran and Pakistan. Leaves and fruits can be prepared as food flavorings, juices, and teas. Phytochemical analysis of these species has reported alkaloids, tannins, phenolic compounds and oleanolic acid, among others. Moreover, p-cymene, limonene and ocimen ...
DOI:
10.3390/foods8100522
PubMed:
31652576
PubMed Central:
PMC6836240

8. Lactobacillus acidophilus-Fermented Germinated Brown Rice Suppresses Preneoplastic Lesions of the Colon in Rats

Author:
Sing-Chung Li; Han-Pei Lin; Jung-Su Chang; Chun-Kuang Shih
Source:
Nutrients 2019 v.11 no.11 pp. -
ISSN:
2072-6643
Subject:
1,2-dimethylhydrazine; B-cell lymphoma; Lactobacillus acidophilus; antineoplastic activity; apoptosis; blood serum; brown rice; carcinogenesis; caspase-3; chemoprevention; colon; colorectal neoplasms; dextran sulfate; dietary supplements; inflammation; interleukin-1beta; interleukin-6; probiotics; protective effect; rats; tumor necrosis factor-alpha; whole grain foods
Abstract:
... Colorectal cancer (CRC) is a cancer associated with chronic inflammation. Whole grains and probiotics play a protective role against CRC. Fermented grains are receiving increased attention due to their anti-inflammatory and anti-cancer activities. Our previous study found that a combination of germinated brown rice (GBR) with probiotics suppressed colorectal carcinogenesis in rats. However, the ca ...
DOI:
10.3390/nu11112718
PubMed:
31717536
PubMed Central:
PMC6893647

9. AKT1-targeted proapoptotic activity of compound K in human breast cancer cells

Author:
Eunju Choi; Eunji Kim; Ji Hye Kim; Keejung Yoon; Sunggyu Kim; Jongsung Lee; Jae Youl Cho
Source:
Journal of Ginseng Research 2019 v.43 no.4 pp. 692-698
ISSN:
1226-8453
Subject:
Panax; antineoplastic activity; apoptosis; breast neoplasms; cancer therapy; caspase-7; caspase-8; caspase-9; cell viability; death; disease severity; flow cytometry; humans; immunoblotting; intestines; metabolites; neoplasm cells; propidium; research; saponins
Abstract:
... Breast cancer is a severe disease and the second leading cause of cancer death in women worldwide. To surmount this, various diagnosis and treatment options for breast cancer have been developed. One of the most effective strategies for cancer treatment is to induce apoptosis using naturally occurring compounds. Compound K (CK) is a ginseng saponin metabolite generated by human intestinal bacteria ...
DOI:
10.1016/j.jgr.2019.07.001

10. Acacetin‐induced cell apoptosis in head and neck squamous cell carcinoma cells: Evidence for the role of muscarinic M3 receptor

Author:
Fenglin Sun; Duo Li; Cong Wang; Caixia Peng; Hong Zheng; Xiaofeng Wang
Source:
Phytotherapy research 2019 v.33 no.5 pp. 1551-1561
ISSN:
0951-418X
Subject:
antineoplastic activity; apoptosis; calcium; calcium signaling; caspase-3; caspase-9; cell lines; cell viability; cytochrome c; electron microscopy; flavones; flow cytometry; mitochondria; neoplasm cells; small interfering RNA; squamous cell carcinoma
Abstract:
... Aacacetin, a plant flavone has shown antitumor efficacy recently. However, its associated mechanisms are poorly known. We hypothesized that the muscarinic M3 receptor (M₃R), which is highly expressed in some cancer tissue, is related to the antitumor effect of acacetin in head and neck squamous cell carcinoma (HNSCC) cells. Our results showed that 12.5‐ to 200‐μM acacetin inhibited cell viability ...
DOI:
10.1002/ptr.6343

11. Acid and light stimuli-responsive mesoporous silica nanoparticles for controlled release

Author:
Mingdong Wang; Ting Wang; Dong Wang; Wei Jiang; Jiajun Fu
Source:
Journal of materials science 2019 v.54 no.8 pp. 6199-6211
ISSN:
0022-2461
Subject:
alpha-cyclodextrin; antineoplastic activity; breast neoplasms; doxorubicin; encapsulation; humans; hydrazones; irradiation; mechanization; nanoparticles; neoplasm cells; pH; porous media; silica; ultraviolet radiation
Abstract:
... We constructed a novel stimuli-responsive system, MSNPs 1, based on mechanized silica nanoparticles, in which mesoporous silica nanoparticles (MSNs) acted as nanocontainers to load cargo, and supramolecular switches consisting of hydrazone bond, azobenzene and α-cyclodextrin (α-CD) realized the controlled release of cargo molecules from MSNPs 1. In neutral solution and without UV light irradiation ...
DOI:
10.1007/s10853-019-03325-x

12. Actinidia chinensis Planch root extract attenuates proliferation and metastasis of hepatocellular carcinoma by inhibiting epithelial-mesenchymal transition

Author:
Tingting Fang; Yuan Fang; Xiaojing Xu; Mingyan He; Zhiying Zhao; Peixin Huang; Feifei Yuan; Mengzhou Guo; Biwei Yang; Jinglin Xia
Source:
Journal of ethnopharmacology 2019 v.231 pp. 474-485
ISSN:
0378-8741
Subject:
Actinidia chinensis; Oriental traditional medicine; animal models; antineoplastic activity; apoptosis; cell proliferation; cell viability; cytotoxicity; diuresis; gene expression; gene expression regulation; genes; hemostasis; hepatoma; herbs; messenger RNA; metastasis; patients; prognosis; quantitative polymerase chain reaction
Abstract:
... Numerous studies have demonstrated the potent anticancer activity of various Chinese herbs. Actinidia chinensis Planch root (acRoots), a traditional Chinese medicine, functions as an antitumor and detoxifying agent and plays a role in diuresis and hemostasis. Treatment with acRoots confers strong inhibition of tumor growth in various forms of cancer. Here, we evaluated the anticancer activity and ...
DOI:
10.1016/j.jep.2018.11.014

13. Activated TNF-α/RIPK3 signaling is involved in prolonged high fat diet-stimulated hepatic inflammation and lipid accumulation: inhibition by dietary fisetin intervention

Author:
Minxuan XuThese authors contributed equally to this work.; Chenxu Ge; Yuting Qin; Tingting Gu; Jinxiao Lv; Sujun Wang; Yongjie Ma; Deshuai Lou; Qiang Li; Linfeng Hu; Xuyuan Nie; Mingxing Wang; Ping Huang; Jun Tan
Source:
Food & function 2019 v.10 no.3 pp. 1302-1316
ISSN:
2042-650X
Subject:
antineoplastic activity; blood serum; fatty liver; flavonoids; gene expression; gene expression regulation; high fat diet; inflammation; lipids; liver; liver function; metabolic diseases; metabolic syndrome; mice; neoplasms; polyphenols; protective effect; protein kinases; tumor necrosis factor-alpha
Abstract:
... Increasing evidence indicates that high-fat diet (HFD) is a predisposing factor for metabolic syndrome-associated systemic inflammation and nonalcoholic fatty liver disease (NAFLD). Tumor necrosis factor-α/receptor-interacting protein kinase 3 (TNF-α/RIPK3) axis has recently become regarded as an important regulator and contributor in many inflammation-related diseases. Fisetin (Fn) is a bioactive ...
DOI:
10.1039/c8fo01615a

14. Ad5-EMC6 mediates antitumor activity in gastric cancer cells through the mitochondrial apoptosis pathway

Author:
Riyong Li; Xiaokun Wang; Xuan Zhang; Jiahong Yu; Jinqiu Feng; Ping Lv; Yaxin Lou; Yingyu Chen
Source:
Biochemical and biophysical research communications 2019 v.513 no.3 pp. 663-668
ISSN:
0006-291X
Subject:
antineoplastic activity; apoptosis; carcinogenesis; cell growth; drug therapy; endoplasmic reticulum; etoposide; membrane potential; mice; mitochondria; mitochondrial membrane; models; neoplasm cells; stomach neoplasms; transmembrane proteins
Abstract:
... Endoplasmic reticulum membrane protein complex subunit 6 (EMC6), also known as transmembrane protein 93 (transmembrane protein 93, TMEM93), is an autophagy-related protein. EMC6 overexpression inhibits cancer cell growth and induces apoptosis, but the interaction partners of EMC6 and its cellular responsibilities remain incompletely understood. In this study, we report that adenovirus-mediated ect ...
DOI:
10.1016/j.bbrc.2019.04.023

15. Advances in phytochemical delivery systems for improved anticancer activity

Author:
Ricardo Lagoa; João Silva; Joaquim Rui Rodrigues; Anupam Bishayee
Source:
Biotechnology advances 2019 pp. -
ISSN:
0734-9750
Subject:
antineoplastic activity; berberine; bioavailability; chemical constituents of plants; colon; curcumin; drug delivery systems; flavonoids; nanoemulsions; nanoparticles; neoplasms; nose; pharmacokinetics; resveratrol
Abstract:
... Natural compounds have significant anticancer pharmacological activities, but often suffer from low bioavailability and selectivity that limit therapeutic use. The present work critically analyzes the latest advances on drug delivery systems designed to enhance pharmacokinetics, targeting, cellular uptake and efficacy of anticancer phytoconstituents. Various phytochemicals, including flavonoids, r ...
DOI:
10.1016/j.biotechadv.2019.04.004

16. AgBiS₂-TPP nanocomposite for mitochondrial targeting photodynamic therapy, photothermal therapy and bio-imaging under 808 nm NIR laser irradiation

Author:
Mingdi Sun; Dan Yang; Chen Wang; Huiting Bi; Yuan Zhou; Xiangxi Wang; Jiating Xu; Fei He; Shili Gai; Piaoping Yang
Source:
Biomaterials science 2019 v.7 no.11 pp. 4769-4781
ISSN:
2047-4849
Subject:
antineoplastic activity; bioimaging; computed tomography; energy; irradiation; mitochondria; nanocomposites; nanoparticles; near infrared radiation; near-infrared spectroscopy; neoplasm cells; neoplasms; patients; photochemotherapy; photothermotherapy; population growth; precision medicine; reactive oxygen species; sulfides
Abstract:
... 808 nm near-infrared (NIR) light-induced biological theranostics is gradually becoming a popular method for cancer treatment. Meanwhile, mild synthetic methods to prepare medicines and gentle treatment conditions for cancer patients are becoming increasingly important to oncotherapy. Herein, tiny AgBiS₂ nanodots were synthesized via a simple method, and for the first time, discovered to produce a ...
DOI:
10.1039/c9bm01077g

17. Ailanthone inhibits cell growth and migration of cisplatin resistant bladder cancer cells through down-regulation of Nrf2, YAP, and c-Myc expression.

Author:
Martina Daga; Stefania Pizzimenti; Chiara Dianzani; Marie Angele Cucci; Roberta Cavalli; Margherita Grattarola; Benedetta Ferrara; Valentina Scariot; Francesco Trotta; Giuseppina Barrera
Source:
Phytomedicine 2019 v.56 pp. 156-164
ISSN:
0944-7113
Subject:
Ailanthus altissima; Western blotting; active ingredients; antibodies; antineoplastic activity; apoptosis; bladder; cell growth; cell lines; cell movement; cisplatin; cortex; essential genes; flow cytometry; gene expression; humans; interphase; neoplasm cells; protein synthesis; staining; therapeutics; tissue repair; toxicity; urinary bladder neoplasms
Abstract:
... Ailanthone (Aila) is a natural active compound isolated from the Ailanthus altissima, which has been shown to possess an “in vitro” growth-inhibitory effect against several cancer cell lines. Advanced bladder cancer is a common disease characterized by a frequent onset of resistance to cisplatin-based therapy. The cisplatin (CDDP) resistance is accompanied by an increase in Nrf2 protein expression ...
DOI:
10.1016/j.phymed.2018.10.034

18. An Alcohol-Soluble Polysaccharide from Atractylodes macrocephala Koidz Induces Apoptosis of Eca-109 cells

Author:
Ying-ying Feng; Hai-yu Ji; Xiao-dan Dong; An-jun Liu
Source:
Carbohydrate polymers 2019 pp. -
ISSN:
0144-8617
Subject:
Atractylodes macrocephala; Fourier transform infrared spectroscopy; Western blotting; antineoplastic activity; apoptosis; arabinose; dyes; esophageal neoplasms; gas chromatography; gel chromatography; glucose; glycosidic linkages; interphase; mitochondria; polysaccharides; rhodamines; staining; therapeutics
Abstract:
... In this study, polysaccharides from Atractylodes macrocephala Koidz (APA) which were soluble in alcohol were prepared, purified, analyzed the structure and investigated the antitumor activity in vitro cell experiment. Results of high-performance gel permeation chromatography (HPGPC), fourier-transform infrared spectroscopy (FT-IR), and gas chromatography (GC) showed that APA was a 2.1KDa neutral h ...
DOI:
10.1016/j.carbpol.2019.115136

19. Algae metabolites: from in vitro growth inhibitory effects to promising anticancer activity

Author:
Florence Lefranc; Aikaterini Koutsaviti; Efstathia Ioannou; Alexander Kornienko; Vassilios Roussis; Robert Kiss; David Newman
Source:
Natural product reports 2019 v.36 no.5 pp. 810-841
ISSN:
1460-4752
Subject:
algae; antineoplastic activity; autotrophs; drug therapy; marine environment; metabolites; metastasis; models; neoplasm cells; neoplasms; signal transduction; transporters
Abstract:
... Covering: 1957 to 2017 Algae constitute a heterogeneous group of eukaryotic photosynthetic organisms, mainly found in the marine environment. Algae produce numerous metabolites that help them cope with the harsh conditions of the marine environment. Because of their structural diversity and uniqueness, these molecules have recently gained a lot of interest for the identification of medicinally use ...
DOI:
10.1039/c8np00057c

20. Alkaloids isolated from Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae: Anticancer activity of coccinine and montanine

Author:
M. Masi; S. Van slambrouck; S. Gunawardana; M.J. van Rensburg; P.C. James; J.G. Mochel; P.S. Heliso; A.S. Albalawi; A. Cimmino; W.A.L. van Otterlo; A. Kornienko; I.R. Green; A. Evidente
Source:
South African journal of botany 2019 v.126 pp. 277-281
ISSN:
0254-6299
Subject:
Haemanthus; antineoplastic activity; bulbs; human cell lines; humans; lycorine; metabolites; neoplasm cells
Abstract:
... Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae, was studied for the first time for its alkaloid content. From the acid extract of its bulbs, albomaculine, incartine, coccinine and montanine, belonging to the lycorine-, homolycorine- and isoquinoline-type alkaloids respectively, were isolated. Coccinine was the main metabolite (1.49 g/kg) and to the best of our knowledge H. hu ...
DOI:
10.1016/j.sajb.2019.01.036