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You searched for: Publication Year 2019 Remove constraint Publication Year: 2019 Subject term antineoplastic activity Remove constraint Subject term: antineoplastic activity
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1. (−)-Oleocanthal Combined with Lapatinib Treatment Synergized against HER-2 Positive Breast Cancer In Vitro and In Vivo

Author:
Abu Bakar Siddique; Hassan Y. Ebrahim; Mohamed R. Akl; Nehad M. Ayoub; Amira A. Goda; Mohamed M. Mohyeldin; Suresh K. Nagumalli; Wael M. Hananeh; Yong-Yu Liu; Sharon A. Meyer; Khalid A. El Sayed
Source:
Nutrients 2019 v.11 no.2 pp. -
ISSN:
2072-6643
Subject:
Western blotting; antibodies; antineoplastic activity; breast neoplasms; breasts; cell lines; enzyme inhibitors; epidermal growth factor receptors; epithelium; erbB-2 receptor; extra-virgin olive oil; mice; models; neoplasm cells; non-specific protein-tyrosine kinase; non-specific serine/threonine protein kinase; therapeutics; tyrosine
Abstract:
... Dysregulation of epidermal growth factor receptor (EGFR)/human epidermal growth factor-2 (HER2) family is a hallmark of aggressive breast cancer. Small-molecule tyrosine kinase inhibitors are among the most effective cancer targeted treatments. (−)-Oleocanthal (OC) is a naturally occurring phenolic secoiridoid lead from extra-virgin olive oil with documented anti-cancer activities via target ...
DOI:
10.3390/nu11020412
PubMed:
30781364
PubMed Central:
PMC6412724

2. 16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity in vivo and in vitro

Author:
Yiren Yang; Liping Long; Xinxin Zhang; Kairu Song; Da Wang; Xin Xiong; Huiyuan Gao; Luping Sha
Source:
RSC advances 2019 v.9 no.54 pp. 31758-31772
ISSN:
2046-2069
Subject:
antineoplastic activity; apoptosis; breasts; doxorubicin; glycosides; hemolysis; human cell lines; humans; hydrolysates; lungs; metastasis; mice; neoplasm cells; neoplasm progression; toxicity; triterpenoids; uterine cervical neoplasms
Abstract:
... Barrigenol-like triterpenoids (BATs) showed promising anti-tumor, anti-inflammatory and anti-Alzheimer's activities, while, the inhibitory strength was usually affected by their states with aglycones or glycosides. In order to find more BATs as new anti-tumor agents with much more efficiency, the chemical and pharmaceutical studies were carried out on the acid hydrolysate product (AHP) of Semen Ae ...
DOI:
10.1039/c9ra06015d

3. 1‐O‐alkylglycerols from the hepatopancreas of the crab Paralithodes camtschaticus, liver of the squid Berryteuthis magister, and liver of the skate Bathyraja parmifera, and their anticancer activity on human melanoma cells

Author:
Nikolay A. Latyshev; Svetlana P. Ermakova; Ekaterina V. Ermolenko; Andrey B. Imbs; Sergey P. Kasyanov; Ruslan M. Sultanov
Source:
Journal of food biochemistry 2019 v.43 no.5 pp. e12828
ISSN:
0145-8884
Subject:
Bathyraja; Paralithodes camtschatica; antineoplastic activity; aquatic organisms; crabs; cytotoxicity; hepatopancreas; human cell lines; inhibitory concentration 50; lipids; liver; melanoma; squid; therapeutics
Abstract:
... 1‐O‐alkylglycerols (AKG) are a class of natural ether lipids derived from 1‐O‐alkyl‐2,3‐diacyl‐sn‐glycerols by deacylation. In this study, 1‐O‐alkylglycerol (AKG) composition was investigated in the hepatopancreas lipids of the crab Paralithodes camtschaticus and the liver lipids of the squid Berryteuthis magister and the skate Bathyraja parmifera. One of the principal AKG in marine organisms was ...
DOI:
10.1111/jfbc.12828

4. 2,4-Dihydroxy-3′-methoxy-4′-ethoxychalcone suppresses cell proliferation and induces apoptosis of multiple myeloma via the PI3K/akt/mTOR signaling pathway

Author:
FengChen Zhu; DianMing Jiang; MingHua Zhang; Bo Zhao
Source:
Pharmaceutical biology 2019 v.57 no.1 pp. 641-648
ISSN:
1744-5116
Subject:
Caragana; NAD ADP-ribosyltransferase; Western blotting; antineoplastic activity; apoptosis; cell proliferation; cytochrome c; flow cytometry; fluorescence microscopes; in vivo studies; inhibitory concentration 50; insulin-like growth factor I; myeloma; phosphatidylinositol 3-kinase; rapamycin; signal transduction; traditional medicine
Abstract:
... Context: Caragana pruinosa Kom. (Fabaceae), a commonly used folk medicine, has been found to possess antitumor effects. However, the antiproliferative effect of 2,4-dihydroxy-3′-methoxy-4′-ethoxychalcone (DMEC) derived from C. pruinosa against multiple myeloma (MM) has never been investigated. Objective: This study systematically evaluates the antiproliferative effect of DMEC against MM cells. Mat ...
DOI:
10.1080/13880209.2019.1662814
PubMed:
31564190
PubMed Central:
PMC6781472

5. 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells

Author:
Wuguo Li; Qing Zhang; Kaotan Chen; Zhenhua Sima; Jingli Liu; Qiang Yu; Jiawei Liu
Source:
BMC complementary and alternative medicine 2019 v.19 no.1 pp. 38
ISSN:
1472-6882
Subject:
Reynoutria japonica; Western blotting; alternative medicine; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle; cell growth; cell viability; chemical structure; dose response; drug resistance; ethyl acetate; flow cytometry; gels; hepatoma; high performance liquid chromatography; humans; inhibitory concentration 50; juglone; luciferase; metastasis; nuclear magnetic resonance spectroscopy; oncogenes; phosphorylation; physicochemical properties; relapse; reporter genes; roots; signal transduction; spectral analysis; stem cells; transactivators; transcription (genetics); tyrosine
Abstract:
... BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is an oncogene constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells (CSCs). Constitutively activated STAT3 plays a pivotal role in holding cancer stemness of HCC CSCs, which are essential for hepatoma initiation, relapse, metastasis and drug resistance. Therefore, STAT3 has been validated a ...
DOI:
10.1186/s12906-019-2440-9
PubMed:
30709346
PubMed Central:
PMC6359800

6. 2-Methylpyridine-1-ium-1-sulfonate as an Inducer of Apoptosis and Cell Cycle Arrest: A comparative in vitro and Computational Study

Author:
Hamid-Reza Mohammadi-Motlagh; Reza Yarani; Mona Sadeghalvad; Elham Adham; Hassan Rasouli; Ali Mostafaie
Source:
Nutrition and cancer 2019 v.71 no.4 pp. 643-656
ISSN:
1532-7914
Subject:
Allium; DNA fragmentation; antineoplastic activity; apoptosis; bulbs; cell cycle checkpoints; computer simulation; cyclins; dose response; gastrointestinal neoplasms; human cell lines; mechanism of action; medicinal plants; medicine; neoplasm cells; phosphotransferases (kinases)
Abstract:
... “Let food be thy medicine and thy medicine be thy food” was expressed by Hippocrates and the health benefits of medicinal plants and natural products have been considered by humans since historic times. The current study aims to investigate the anti-cancer activity of 2-Methylpyridine-1-ium-1-sulfonate (MPS) isolated from bulbs of Allium hirtifolium. The MPS compound (in a dose-dependent manner) i ...
DOI:
10.1080/01635581.2018.1506495

7. 2′-Hydroxyflavanone induced changes in the proteomic profile of breast cancer cells

Author:
Lokesh D. Nagaprashantha; Jyotsana Singhal; Shireen Chikara; Gabriel Gugiu; David Horne; Sanjay Awasthi; Ravi Salgia; Sharad S. Singhal
Source:
Journal of proteomics 2019 v.192 pp. 233-245
ISSN:
1874-3919
Subject:
antineoplastic activity; antineoplastic agents; breast neoplasms; breasts; citrus fruits; epithelial cells; flavonoids; metastasis; neoplasm cells; proteins; proteomics; therapeutics; women
Abstract:
... In spite of rapid advances in understanding of signaling networks associated with the incidence and therapeutic-sensitivity, breast cancer (BC) still remains the most commonly diagnosed and prevalent cancer in women. Emergence of resistance to hormonal interventions in estrogen-receptor (ER) positive BC coupled to loss of ER expression and activation of ER-independent growth factor, heat-shock, MY ...
DOI:
10.1016/j.jprot.2018.09.005

8. 3‐Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau

Author:
Young H. Ko; Katarzyna Niedźwiecka; Margarida Casal; Peter L. Pedersen; Stanisław Ułaszewski
Source:
Yeast 2019 v.36 no.4 pp. 211-221
ISSN:
0749-503X
Subject:
Cryptococcus neoformans; adenosine triphosphate; adverse effects; algae; animal models; antimicrobial properties; antineoplastic activity; apoptosis; bromination; cancer therapy; cell movement; fungi; glucose; glycolysis; hexokinase; lactic acid; mitochondria; neoplasm cells; neoplasms; oxygen; patients; pumps; pyruvic acid; transporters
Abstract:
... 3‐Bromopyruvate (3BP) is a small, highly reactive molecule formed by bromination of pyruvate. In the year 2000, the antitumor properties of 3BP were discovered. Studies using animal models proved its high efficacy for anticancer therapy with no apparent side effects. This was also found to be the case in a limited number of cancer patients treated with 3BP. Due to the “Warburg effect,” most tumor ...
DOI:
10.1002/yea.3367

9. 3′‐Desmethylarctigenin induces G2/M cell cycle arrest and apoptosis through reactive oxygen species generation in hepatocarcinoma cells

Author:
Enxiang Zhang; Xiuling Wang; Xiaoyi Liu; Min Liang; Hongbo Hu; Shutao Yin
Source:
Phytotherapy research 2019 v.33 no.12 pp. 3218-3227
ISSN:
0951-418X
Subject:
antineoplastic activity; apoptosis; cell cycle checkpoints; chemoprevention; hepatoma; human cell lines; mice; mitochondria; models; reactive oxygen species; therapeutics; toxicity
Abstract:
... Previous studies have shown that arctigenin is a promising chemopreventive or therapeutic agent against various cancers. However, less is known about anticancer activity of 3′‐desmethylarctigenin (3′‐DMAG), which is a biotransformed product from arctigenin or arctin. In this study, we compared the anticancer activity of 3′‐DMAG with its parent compound arctigenin and demonstrated that 3′‐DMAG exer ...
DOI:
10.1002/ptr.6496

10. 4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer

Author:
Zhicong Zhao; Dongsheng Shang; Lipeng Qiu; Chang Guo; Yanyan Li; Hanqing Liu; Guoyue Yuan; Zhigang Tu
Source:
Life sciences 2019 v.238 pp. 116973
ISSN:
0024-3205
Subject:
DNA damage; antineoplastic activity; antineoplastic agents; cell senescence; drug therapy; enzymes; fluorescent antibody technique; heterocyclic nitrogen compounds; in vitro studies; in vivo studies; mice; screening; signal transduction; staining; stomach neoplasms; survival rate
Abstract:
... Gastric cancer (GC) is a common cancer with a relatively low survival rate. Cellular senescence, a potent anti-cancer mechanism, is naturally occurred, and can be induced by chemotherapeutic agents. We sought to explore new compounds against GC cells by inducing cellular senescence.Primary screening of a library of N-heterocyclic compounds identified some with potent inhibitory effects on GC cells ...
DOI:
10.1016/j.lfs.2019.116973

11. 5-Acetamido-1-(methoxybenzyl) isatin inhibits tumor cell proliferation, migration, and angiogenesis

Author:
Qian Zhang; Ying Fu; Yufan Zhao; Shanshan Cui; Jing Wang; Fengxi Liu; Yuan Yuan; Hervé Galons; Peng Yu; Yuou Teng
Source:
RSC advances 2019 v.9 no.63 pp. 36690-36698
ISSN:
2046-2069
Subject:
angiogenesis; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cell proliferation; chemotaxis; cyclins; flow cytometry; human umbilical vein endothelial cells; humans; indoles; liver neoplasms; mitochondria; neoplasm cells
Abstract:
... Indole and its derivatives are widely distributed in both animals and plants. Among its array of biological activities, the anti-tumor activity of indole has garnered much attention. Furthermore, the synthesis and activity of indole derivatives, including isatin, constitute a flourishing research topic. Previously, many isatin derivatives were synthesized by our group, and 5-acetamido-1-(methoxybe ...
DOI:
10.1039/c9ra07002h

12. 5-Fluorouracil-loaded β-cyclodextrin-carrying polymeric poly(methylmethacrylate)-coated samarium ferrite nanoparticles and their anticancer activity

Author:
M. S. Hariharan; R. Sivaraj; S. Ponsubha; R. Jagadeesh; I. V. M. V. Enoch
Source:
Journal of materials science 2019 v.54 no.6 pp. 4942-4951
ISSN:
0022-2461
Subject:
antineoplastic activity; beta-cyclodextrin; cytotoxicity; energy-dispersive X-ray analysis; ferrimagnetic materials; fluorouracil; magnetic fields; magnetic properties; nanocarriers; nanoparticles; neoplasms; polymers; samarium; spectroscopy
Abstract:
... Drug-loading on magnetic nanoparticles coated with biocompatible polymers are intriguing nanostructures for targeted delivery of anticancer drugs with the application of a magnetic field. In this paper, we report the preparation of SmFeO₃ nanoparticles and loading of the anticancer drug 5-fluorouracil on the carrier by forming host–guest complex with β-cyclodextrin. The material and the polymer ar ...
DOI:
10.1007/s10853-018-3161-z

13. 7-O-geranylquercetin contributes to reverse P-gp-mediated adriamycin resistance in breast cancer

Author:
Enxia Zhang; Jiasi Liu; Lei Shi; Xin Guo; Ze Liang; Jiaxin Zuo; Hong Xu; Huaxin Wang; Xiaohong Shu; Shanshan Huang; Shubiao Zhang; Xiaohui Kang; Yuhong Zhen
Source:
Life sciences 2019 v.238 pp. 116938
ISSN:
0024-3205
Subject:
P-glycoproteins; Western blotting; antineoplastic activity; breast neoplasms; caudal vein; computer simulation; doxorubicin; drug resistance; drug therapy; flow cytometry; fluorescence microscopes; fluorescence microscopy; gene expression regulation; genes; mice; molecular models; quantitative polymerase chain reaction; quercetin; rhodamines; tissues; toxicity testing; viability
Abstract:
... To investigate the effect of 7-O-geranylquercetin (GQ), a derivative of quercetin (Q), on reversing drug resistance in breast cancer MCF-7/ADR cells and reveal the mechanisms related to P-glycoprotein (P-gp).Cell viability was determined by MTT assay. Accumulation of adriamycin (ADR) in cells was determined by confocal fluorescence microscope and microplate reader while that of rhodamine (Rh) was ...
DOI:
10.1016/j.lfs.2019.116938

14. Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer

Author:
Oluwaseun Adebayo Bamodu; Kuang-Tai Kuo; Chun-Hua Wang; Wen-Chien Huang; Alexander T.H. Wu; Jo-Ting Tsai; Kang-Yun Lee; Chi-Tai Yeh; Liang-Shun Wang
Source:
Nutrients 2019 v.11 no.10 pp. -
ISSN:
2072-6643
Subject:
Astragalus membranaceus; active ingredients; animal models; antineoplastic activity; carcinoma; cell proliferation; cisplatin; cytotoxic T-lymphocytes; dendritic cells; immune response; immunogenicity; in vivo studies; interleukin-10; interleukin-6; lung neoplasms; macrophages; metastasis; patients; polysaccharides; quality of life; roots; therapeutics; weight loss
Abstract:
... Background: Recently, we demonstrated that Astragalus polysaccharide (PG2), the active ingredient in dried roots of astragalus membranaceus, ameliorates cancer symptom clusters and improves quality of life (QoL) in patients with metastatic disease by modulating inflammatory cascade against the background roles of inflammatory cells, including macrophages, dendritic cells (DCs), and cytotoxic T lym ...
DOI:
10.3390/nu11102264
PubMed:
31547048
PubMed Central:
PMC6836209

15. Berberis Plants—Drifting from Farm to Food Applications, Phytotherapy, and Phytopharmacology

Author:
Bahare Salehi; Zeliha Selamoglu; Bilge Sener; Mehtap Kilic; Arun Kumar Jugran; Nunziatina de Tommasi; Chiara Sinisgalli; Luigi Milella; Jovana Rajkovic; Maria Flaviana B. Morais-Braga; Camila F. Bezerra; Janaína E. Rocha; Henrique D.M. Coutinho; Adedayo Oluwaseun Ademiluyi; Zabta Khan Shinwari; Sohail Ahmad Jan; Ebru Erol; Zulfiqar Ali; Elise Adrian Ostrander; Javad Sharifi-Rad; María de la Luz Cádiz-Gurrea; Yasaman Taheri; Miquel Martorell; Antonio Segura-Carretero; William C. Cho
Source:
Foods 2019 v.8 no.10 pp. -
ISSN:
2304-8158
Subject:
Berberis; alkaloids; antimicrobial properties; antineoplastic activity; antioxidants; bioactive compounds; chemical constituents of plants; diabetes; essential oils; farms; flavorings; food industry; food preservation; fruit juices; fruits; gas chromatography; leaves; limonene; neoplasms; ocimene; oleanolic acid; p-cymene; pharmaceutical industry; phytotherapy; tannins; toxicity; Europe; Iran; Pakistan; United States
Abstract:
... The genus Berberis includes about 500 different species and commonly grown in Europe, the United States, South Asia, and some northern areas of Iran and Pakistan. Leaves and fruits can be prepared as food flavorings, juices, and teas. Phytochemical analysis of these species has reported alkaloids, tannins, phenolic compounds and oleanolic acid, among others. Moreover, p-cymene, limonene and ocimen ...
DOI:
10.3390/foods8100522
PubMed:
31652576
PubMed Central:
PMC6836240

16. Lactobacillus acidophilus-Fermented Germinated Brown Rice Suppresses Preneoplastic Lesions of the Colon in Rats

Author:
Sing-Chung Li; Han-Pei Lin; Jung-Su Chang; Chun-Kuang Shih
Source:
Nutrients 2019 v.11 no.11 pp. -
ISSN:
2072-6643
Subject:
1,2-dimethylhydrazine; B-cell lymphoma; Lactobacillus acidophilus; antineoplastic activity; apoptosis; blood serum; brown rice; carcinogenesis; caspase-3; chemoprevention; colon; colorectal neoplasms; dextran sulfate; dietary supplements; inflammation; interleukin-1beta; interleukin-6; probiotics; protective effect; rats; tumor necrosis factor-alpha; whole grain foods
Abstract:
... Colorectal cancer (CRC) is a cancer associated with chronic inflammation. Whole grains and probiotics play a protective role against CRC. Fermented grains are receiving increased attention due to their anti-inflammatory and anti-cancer activities. Our previous study found that a combination of germinated brown rice (GBR) with probiotics suppressed colorectal carcinogenesis in rats. However, the ca ...
DOI:
10.3390/nu11112718
PubMed:
31717536
PubMed Central:
PMC6893647

17. A C-type lectin from Bothrops leucurus snake venom forms amyloid-like aggregates in RPMI medium and are efficiently phagocytosed by peritoneal macrophages

Author:
Mary Ângela Aranda-Souza; Vírginia Maria Barros de Lorena; Maria Tereza dos Santos Correia; Antonio Pereira-Neves; Regina Celia Bressan Queiroz de Figueiredo
Source:
Toxicon 2019 v.157 pp. 93-100
ISSN:
0041-0101
Subject:
Bothrops; amyloid; antibodies; antineoplastic activity; carbohydrate binding; cell culture; culture media; cytochalasin B; electron microscopy; galactose; humans; inflammation; interleukin-10; interleukin-1beta; interleukin-6; lectins; macrophages; models; pH; phagocytosis; protein deposition; snake venoms; staining; tumor necrosis factor-alpha; viability
Abstract:
... Lectins are carbohydrate-binding proteins that play important roles in the immune system. Under specific conditions, lectins can form amyloids, proteinaceous aggregates rich in cross β-strand structures. A Ca++-dependent lectin, isolated from Bothrops leucurus snake venom (BLL) has demonstrated relevant biological activities such as antibacterial and antitumor activity. In this work, we aimed to s ...
DOI:
10.1016/j.toxicon.2018.11.309

18. A Combination of Rosa Canina Extracts and Gold Complex Favors Apoptosis of Caco-2 Cells by Increasing Oxidative Stress and Mitochondrial Dysfunction

Author:
Inés Mármol; Nerea Jiménez-Moreno; Carmen Ancín-Azpilicueta; Jesús Osada; Elena Cerrada; María Jesús Rodríguez-Yoldi
Source:
Antioxidants 2019 v.9 no.1 pp. -
ISSN:
2076-3921
Subject:
DNA; Rosa canina; antineoplastic activity; apoptosis; colorectal neoplasms; drug therapy; drugs; exposure duration; gold; human cell lines; mitochondria; models; oxidative stress; polyphenols; reactive oxygen species; rose hips
Abstract:
... Given the alarming increase in colorectal cancer (CRC) worldwide, novel therapies are urgently needed. Plant-derived extracts have gained considerable interest in the last years due to their strong anticancer effect mediated by their unique bioactive compounds. Specifically, rosehips from Rosa canina have been successfully tested against several cancer models, including colon cancer. Moreov ...
DOI:
10.3390/antiox9010017

19. A DNA vaccine expressing an optimized secreted FAPα induces enhanced anti-tumor activity by altering the tumor microenvironment in a murine model of breast cancer

Author:
Fei Geng; Jie Guo; Qian-Qian Guo; Yu Xie; Ling Dong; Yi Zhou; Chen-Lu Liu; Bin Yu; Hui Wu; Jia-Xin Wu; Hai-Hong Zhang; Wei Kong; Xiang-Hui Yu
Source:
Vaccine 2019 v.37 no.31 pp. 4382-4391
ISSN:
0264-410X
Subject:
CD8-positive T-lymphocytes; animal models; antigens; antineoplastic activity; breast neoplasms; chemokine CCL2; chemokine CXCL12; clinical trials; codons; fibroblasts; humans; immune response; immunogenicity; metastasis; mice; recombinant vaccines; secretion; signal peptide; suppressor cells; t-plasminogen activator
Abstract:
... Cancer-associated fibroblasts (CAFs), major components of the tumor microenvironment (TME), promote tumor growth and metastasis and inhibit the anti-tumor immune response. We previously constructed a DNA vaccine expressing human FAPα, which is highly expressed by CAFs, to target these cells in the TME, and observed limited anti-tumor effects in the 4T1 breast cancer model. When the treatment time ...
DOI:
10.1016/j.vaccine.2019.06.012

20. A Facile Synthesis of Itaconic Acid Based Biodegradable Co-polyesters: An In-Vitro Anticancer Evaluation and Controlled Drug Delivery System

Author:
Udayakumar Veerabagu; Gowsika Jaikumar; Lu Fushen
Source:
Journal of polymers and the environment 2019 v.27 no.12 pp. 2756-2768
ISSN:
1566-2543
Subject:
Fourier transform infrared spectroscopy; X-ray diffraction; antineoplastic activity; biodegradability; breast neoplasms; carbon; catalysts; citrates; coatings; condensation reactions; crystal structure; differential scanning calorimetry; drug carriers; glass transition temperature; glycols; human cell lines; humans; inhibitory concentration 50; melting point; nuclear magnetic resonance spectroscopy; pH; polyesters; scanning electron microscopes; scanning electron microscopy; spectral analysis; stable isotopes; tamoxifen; titanium; toxicity; wide-angle X-ray scattering
Abstract:
... A series of aliphatic co-polyesters were prepared via one-step polycondensation reaction of itaconic acid, 1,4-cyclohexane dimethanol and diols using titanium tetraisopropoxide (TTIP) as a catalyst. The chemical structure of the repeating units present in the polymer chains were confirmed by FTIR, ¹H and ¹³C NMR spectral data. The glass transition temperature (Tg), melting temperature (Tₘ) and dec ...
DOI:
10.1007/s10924-019-01562-4

21. A Novel Marine Natural Product Derived Pyrroloiminoquinone with Potent Activity against Skin Cancer Cells

Author:
Jaden Cowan; Mohammad Shadab; Dwayaja H. Nadkarni; Kailash KC; Sadanandan E. Velu; Nabiha Yusuf
Source:
Marine drugs 2019 v.17 no.8 pp. -
ISSN:
1660-3397
Subject:
Western blotting; adverse effects; antineoplastic activity; antineoplastic agents; apoptosis; autophagy; cell movement; humans; keratinocytes; neoplasm cells; proteins; quinones; skin (animal); skin neoplasms; squamous cell carcinoma; tissue repair; toxicity; toxicity testing
Abstract:
... Non-melanoma skin cancer is one of the major ailments in the United States. Effective drugs that can cure skin cancers are limited. Moreover, the available drugs have toxic side effects. Therefore, skin cancer drugs with less toxic side effects are urgently needed. To achieve this goal, we focused our work on identifying potent lead compounds from marine natural products. Five lead compounds ident ...
DOI:
10.3390/md17080443
PubMed:
31357586
PubMed Central:
PMC6722685

22. A PEGylated alternating copolymer with oxidation-sensitive phenylboronic ester pendants for anticancer drug delivery

Author:
Yu Zhang; Pan He; Xinming Liu; Huailin Yang; Hongyu Zhang; Chunsheng Xiao; Xuesi Chen
Source:
Biomaterials science 2019 v.7 no.9 pp. 3898-3905
ISSN:
2047-4849
Subject:
antineoplastic activity; aqueous solutions; cell viability; composite polymers; confocal laser scanning microscopy; copolymerization; cytotoxicity; doxorubicin; encapsulation; flow cytometry; hydrogen peroxide; hydrophobicity; mice; micelles; nanocarriers; nanoparticles; neoplasms; oxidation; oxidative stress; pH; phenylboronic acids; polyethylene glycol; tetrazolium
Abstract:
... To target a response to a high oxidative stress environment of inflammatory or tumor sites, various reactive oxygen species (ROS) sensitive polymers have been developed as drug delivery systems. In this study, a novel oxidation sensitive copolymer, phenylboronic acid pinacol ester-functionalized methoxyl poly(ethylene glycol)-block-poly(phthalic anhydride-alter-glycidyl propargyl ether) (mPEG-b-P( ...
DOI:
10.1039/c9bm00884e

23. A Redox Stimulation-Activated Amphiphile for Enhanced Photodynamic Therapy

Author:
Yudong Xue; Jia Tian; Zhiyong Liu; Jianbo Chen; Mengsi Wu; Yongjia Shen; Weian Zhang
Source:
Biomacromolecules 2019 v.20 no.7 pp. 2796-2808
ISSN:
1526-4602
Subject:
antineoplastic activity; biosecurity; cytotoxicity; fluorescence; glutathione; image analysis; micelles; neoplasms; photochemotherapy; photosensitizing agents; phototoxicity; polyethylene glycol; singlet oxygen; surfactants; thiols; tissues
Abstract:
... The development of more efficient photosensitizers with minimal damage to surrounding normal tissues has been a valuable and challenging subject during photodynamic therapy (PDT). Herein, a stimuli-activated porphyrinic photosensitizer (PEG-TPP-DNB; PEG = poly(ethylene glycol); TPP = 5,10,15,20-tetraphenylporphyrin; DNB = 2,4-dinitrobenzene) with capabilities of fluorescence and, remarkably, singl ...
DOI:
10.1021/acs.biomac.9b00581

24. A Strategy of Killing Three Birds with One Stone for Cancer Therapy through Regulating the Tumor Microenvironment by H₂O₂-Responsive Gene Delivery System

Author:
Huapan Fang; Jie Chen; Lin Lin; Feng Liu; Huayu Tian; Xuesi Chen
Source:
ACS applied materials & interfaces 2019 v.11 no.51 pp. 47785-47797
ISSN:
1944-8252
Subject:
antineoplastic activity; apoptosis; cancer therapy; dextran; endocytosis; gene transfer; half life; hydrogen peroxide; neoplasm cells; neoplasms; permeability; plasmids; toxicity; vascular endothelial growth factors
Abstract:
... Constructing an efficient in vivo gene delivery system has always been extremely challenging. Herein, a highly efficient H₂O₂-responsive in vivo polycationic gene delivery system is developed for the first time. The efficient vector PLL-RT (i.e., polylysine grafted with p-tosyl-l-arginine) is used to mediate plasmid DNA (pDNA) delivery, and H₂O₂-responsive thioketal dipropanedioic acid-modified de ...
DOI:
10.1021/acsami.9b18144

25. A Systematic Study of the Metabolites of Dietary Acacetin in Vivo and in Vitro Based on UHPLC-Q-TOF-MS/MS Analysis

Author:
Jintuo Yin; Yinling Ma; Caijuan Liang; Jin Gao; Hairong Wang; Lantong Zhang
Source:
Journal of agricultural and food chemistry 2019 v.67 no.19 pp. 5530-5543
ISSN:
1520-5118
Subject:
Acacia; antineoplastic activity; bile; biochemical pathways; feces; high performance liquid chromatography; honey; hydrolysis; liver microsomes; metabolism; metabolites; methylation; oxidation; rats; spectrometers; sulfates; tandem mass spectrometry; ultra-performance liquid chromatography; urine
Abstract:
... Acacetin, a dietary component, is abundant in acacia honey and has superior anticancer activities. To date, no research on the metabolism of acacetin has been reported. In the current research, an online detection strategy of ultra-high-performance liquid chromatography connected to a quadrupole time-of-flight mass spectrometer (UHPLC-Q-TOF-MS/MS) was utilized for metabolite identification in vivo ...
DOI:
10.1021/acs.jafc.9b00330

26. A biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging guided combinatorial cancer therapy

Author:
Xiao Sun; Guilong Zhang; Ruohong Du; Rui Xu; Dongwang Zhu; Junchao Qian; Guo Bai; Chi Yang; Zhiyuan Zhang; Xin Zhang; Duohong Zou; Zhengyan Wu
Source:
Biomaterials 2019 v.194 pp. 151-160
ISSN:
0142-9612
Subject:
antineoplastic activity; antineoplastic agents; apoptosis; biodegradability; catalytic activity; glutathione; human cell lines; hydroxyl radicals; iron oxides; magnetic resonance imaging; manganese; nanocrystals; nanoparticles; neoplasm cells; neoplasms; surface area; therapeutics; toxicity
Abstract:
... In this work, a tumor microenvironment (TME)-responsive biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging (MRI)-guided combinatorial cancer therapy was constructed. Fe3O4 nanoparticles decorated on the surface of MnSiO3 could effectively obstruct the pores of MnSiO3 and reduce the leakage of anticancer drugs under physiological conditions. The structure of the nanopl ...
DOI:
10.1016/j.biomaterials.2018.12.004

27. A bioinspired in vitro bioelectronic tongue with human T2R38 receptor for high-specificity detection of N-C=S-containing compounds

Author:
Chunlian Qin; Zhen Qin; Dongxiao Zhao; Yuxiang Pan; Liujing Zhuang; Hao Wan; Antonella Di Pizio; Einav Malach; Masha Y. Niv; Liquan Huang; Ning Hu; Ping Wang
Source:
Talanta 2019 v.199 pp. 131-139
ISSN:
0039-9140
Subject:
agonists; antineoplastic activity; bitter-tasting compounds; bitterness; drugs; electronic tongue; food industry; human cell lines; humans; intestines; ligands; models; moieties; neoplasm cells; neoplasms; propylthiouracil; screening; taste; taste receptors; tongue
Abstract:
... Detection and identification of bitter compounds draw great attention in pharmaceutical and food industry. Several well-known agonists of specific bitter taste receptors have been found to exhibit anti-cancer effects. For example, N-C=S-containing compounds, such as allyl-isothiocyanates, have shown cancer chemo-preventive effects. It is worth noting that human T2R38 receptor is specific for compo ...
DOI:
10.1016/j.talanta.2019.02.021

28. A cascade-reaction enabled synergistic cancer starvation/ROS-mediated/chemo-therapy with an enzyme modified Fe-based MOF

Author:
Zongjun LiuThese authors contributed equally to this work.; Tuo Li; Fang Han; You Wang; Yang Gan; Junhui Shi; Tianran Wang; Muhammad Luqman Akhtar; Yu Li
Source:
Biomaterials science 2019 v.7 no.9 pp. 3683-3692
ISSN:
2047-4849
Subject:
antineoplastic activity; catalytic activity; coordination polymers; drug therapy; drugs; energy; gluconic acid; glucose; glucose oxidase; hydrogen peroxide; hydroxyl radicals; iron; neoplasm cells; neoplasms; protons; starvation
Abstract:
... Synergistic cancer starvation/ROS-mediated/chemo-therapy is developed through a cascade reaction with enzyme glucose oxidase (GOX) modified on the surface of an Fe-based metal organic framework (MOF(Fe)) and drug camptothecin (CPT) loaded into the cavities of MOF(Fe). Once internalized by tumor cells, GOX catalyzes endogenous glucose into hydrogen peroxide (H₂O₂) and gluconic acid (H⁺) enabling st ...
DOI:
10.1039/c9bm00641a

29. A comprehensive genomic and growth proteomic analysis of antitumor lipopeptide bacillomycin Lb biosynthesis in Bacillus amyloliquefaciens X030

Author:
Jiao Yang Lu; Kexuan Zhou; Wei Tao Huang; Pengji Zhou; Shuqing Yang; Xiaoli Zhao; Junyan Xie; Liqiu Xia; Xuezhi Ding
Source:
Applied microbiology and biotechnology 2019 v.103 no.18 pp. 7647-7662
ISSN:
0175-7598
Subject:
Bacillus amyloliquefaciens; antineoplastic activity; antiviral properties; bacterial growth; biosynthesis; databases; drugs; engineering; enzymes; fermentation; genetic engineering; genomics; glutamic acid; iturin; multigene family; multiomics; neoplasm cells; neoplasms; proteomics; quantitative polymerase chain reaction; regulatory proteins; sucrose; surfactin; transcription (genetics)
Abstract:
... Lipopeptides (such as iturin, fengycin, and surfactin) from Bacillus possess antibacterial, antifungal, and antiviral activities and have important application in agriculture and pharmaceuticals. Although unremitting efforts have been devoted to improve lipopeptide production by designing gene regulatory circuits or optimizing fermentation process, little attention has been paid to utilizing multi ...
DOI:
10.1007/s00253-019-10019-6

30. A comprehensive study of eriocitrin metabolism in vivo and in vitro based on an efficient UHPLC-Q-TOF-MS/MS strategy

Author:
Luya Li; Xue Feng; Yuting Chen; Shenghao Li; Yupeng Sun; Lantong Zhang
Source:
RSC advances 2019 v.9 no.43 pp. 24963-24980
ISSN:
2046-2069
Subject:
antineoplastic activity; antioxidants; biochemical pathways; carboxylic acids; data collection; demethylation; flavonoids; glutamine; high performance liquid chromatography; hydrogenation; information processing; lemons; mass spectrometry; metabolites; methylation; oxidation; sulfates; ultra-performance liquid chromatography; wines
Abstract:
... Eriocitrin, a main flavonoid in lemons, possesses strong antioxidant, lipid-lowering and anticancer activities and has long been used in food, beverages and wine. However, its metabolism in vivo and in vitro is still unclear. In this study, an efficient strategy was developed to detect and identify metabolites of eriocitrin by using ultra-high-performance liquid chromatography coupled with hybrid ...
DOI:
10.1039/c9ra03037a

31. A curcumin derivative, WZ35, suppresses hepatocellular cancer cell growth via downregulating YAP-mediated autophagy

Author:
Lihua WangThese authors contributed equally to this work.; Zheng Zhu; Lei Han; Liqian Zhao; Jialei Weng; Hongbao Yang; Shijia Wu; Kaiyuan Chen; Liang Wu; Tongke Chen
Source:
Food & function 2019 v.10 no.6 pp. 3748-3757
ISSN:
2042-650X
Subject:
Western blotting; antineoplastic activity; apoptosis; autophagy; bioinformatics; cell growth; cell viability; curcumin; death; drugs; flow cytometry; hepatoma; immunotherapy; mitogen-activated protein kinase; monoclonal antibodies; mortality; neoplasm cells; patients; plasmids; small interfering RNA; stomach neoplasms; tissues; transfection
Abstract:
... Hepatocellular carcinoma (HCC) is a common cancer type throughout the world. Due to the high occurrence rate and mortality, liver cancer is one of the leading causes of cancer associated death. With the development of monoclonal antibodies and immunotherapy, the mortality of HCC cancer patients has reduced. However, the recurrence and outcomes of patients remain poor. Therefore, there is an urgent ...
DOI:
10.1039/c8fo02448k

32. A dereplication strategy for identifying triterpene acid analogues in Poria cocos by comparing predicted and acquired UPLC‐ESI‐QTOF‐MS/MS data

Author:
Ye‐Ting Zou; Fang Long; Cheng‐Ying Wu; Jing Zhou; Wei Zhang; Jin‐Di Xu; Ye‐Qing Zhang; Song‐Lin Li
Source:
Phytochemical analysis 2019 v.30 no.3 pp. 292-310
ISSN:
0958-0344
Subject:
Poria; Wolfiporia cocos; antineoplastic activity; antineoplastic agents; bioactive compounds; chemical constituents of plants; databases; herbal medicines; ionization; ions; isomers; prediction; sclerotia; screening; tandem mass spectrometry; triterpene acids; ultra-performance liquid chromatography
Abstract:
... INTRODUCTION: Triterpene acids from the dried sclerotia of Poria cocos (Schw.) Wolf (poria) were recently found to possess anti‐cancer activities. Identification of more triterpene acid analogues in poria is worthwhile for high throughput screening in anti‐cancer drug discovery. OBJECTIVE: To establish an efficient dereplication strategy for identifying triterpene acid analogues in poria based on ...
DOI:
10.1002/pca.2813

33. A dithiocarbamate-based H₂O₂-responsive prodrug for combinational chemotherapy and oxidative stress amplification therapy

Author:
Qingqing Pan; Boya Zhang; Xinyu Peng; Shiyu Wan; Kui Luo; Wenxia Gao; Yuji Pu; Bin He
Source:
Chemical communications 2019 v.55 no.92 pp. 13896-13899
ISSN:
1364-548X
Subject:
antineoplastic activity; chemical reactions; copper; disulfiram; drug therapy; oxidative stress; toxicity
Abstract:
... Here, we report the rational design of a H₂O₂-responsive diethyldithiocarbamate (DTC)-based prodrug, which chelated Cu(ii) to form Cu(DTC)₂ with a high anticancer activity in a tumor-microenvironment and induced oxidative stress amplification, showing superior antitumor toxicity to disulfiram. ...
DOI:
10.1039/c9cc05438c

34. A formulated red ginseng extract inhibits autophagic flux and sensitizes to doxorubicin-induced cell death

Author:
Han-Hee Park; Seung-Won Choi; Gwang Jin Lee; Young-Dae Kim; Hyun-Jin Noh; Seung-Jae Oh; Iseul Yoo; Yu-Jin Ha; Gi-Bang Koo; Soon-Sun Hong; Sung Won Kwon; You-Sun Kim
Source:
Journal of Ginseng Research 2019 v.43 no.1 pp. 86-94
ISSN:
1226-8453
Subject:
Panax; antineoplastic activity; autophagy; cancer therapy; cytotoxicity; doxorubicin; drug therapy; green fluorescent protein; hepatoma; lactate dehydrogenase; liver; neoplasm cells; red fluorescent protein; research; saponins
Abstract:
... Ginseng is believed to have antitumor activity. Autophagy is largely a prosurvival cellular process that is activated in response to cellular stressors, including cytotoxic chemotherapy; therefore, agents that inhibit autophagy can be used as chemosensitizers in cancer treatment. We examined the ability of Korean Red Ginseng extract (RGE) to prevent autophagic flux and to make hepatocellular carci ...
DOI:
10.1016/j.jgr.2017.08.006

35. A green chemistry to produce iron oxide – Chitosan nanocomposite (CS-IONC) for the upgraded bio-restorative and pharmacotherapeutic activities - Supra molecular nanoformulation against drug-resistant pathogens and malignant growth

Author:
Arul Maximus Rabel; S. Karthick Raja Namasivayam; M. Prasanna; R.S. Arvind Bharani
Source:
International journal of biological macromolecules 2019 v.138 pp. 1109-1129
ISSN:
0141-8130
Subject:
Escherichia coli; Fourier transform infrared spectroscopy; Staphylococcus aureus; X-ray diffraction; absorbance; antibacterial properties; antineoplastic activity; apoptosis; biocompatibility; biofilm; cell lines; cell structures; chitosan; cytotoxicity; drug resistance; drug therapy; enzymes; ethanol; green chemistry; humans; iron oxides; medicine; minimum inhibitory concentration; nanocomposites; nanoparticles; pathogens; proteins; scanning electron microscopy; solubilization; tumor necrosis factor-alpha
Abstract:
... The logical research on fundamentally adjusted iron oxide nanoparticles has turned out to expanded in biomedicine because of the improved activity and best biocompatibility. In this present work upgraded bio-restorative and pharmacotherapeutic property of chitosan‑iron oxide nanocomposite, which was set up by eco-friendly in situ substance technique. Characterisation of the synthesised nanocomposi ...
DOI:
10.1016/j.ijbiomac.2019.07.158

36. A histone H2A derived antimicrobial peptide, Fi-Histin from the Indian White shrimp, Fenneropenaeus indicus: Molecular and functional characterization

Author:
K.S. Sruthy; Aishwarya Nair; Swapna P. Antony; Jayesh Puthumana; I.S. Bright Singh; Rosamma Philip
Source:
Fish & shellfish immunology 2019 v.92 pp. 667-679
ISSN:
1050-4648
Subject:
DNA; Fenneropenaeus indicus; Gram-positive bacteria; Pseudomonas aeruginosa; Staphylococcus aureus; Vibrio cholerae; Vibrio parahaemolyticus; Vibrio vulnificus; amino acids; antibacterial properties; antimicrobial peptides; antineoplastic activity; aquaculture; cell membranes; histones; human cell lines; immunology; inhibitory concentration 50; medicine; peptide antibiotics; scanning electron microscopy; synthetic peptides
Abstract:
... Antimicrobial peptides (AMPs) derived from histone proteins form an important category of peptide antibiotics. Present study deals with the molecular and functional characterization of a 27-amino acid histone H2A derived AMP from the Indian White shrimp, Fenneropenaeus indicus designated as Fi-Histin. This peptide displayed distinctive features of AMPs such as amphiphilic alpha helical structure a ...
DOI:
10.1016/j.fsi.2019.06.044

37. A metabolic investigation of anticancer effect of G. glabra root extract on nasopharyngeal carcinoma cell line, C666-1

Author:
Chaopan Zheng; Ling Han; Shihai Wu
Source:
Molecular biology reports 2019 v.46 no.4 pp. 3857-3864
ISSN:
0301-4851
Subject:
Glycyrrhiza glabra; Oriental traditional medicine; alanine; antineoplastic activity; apoptosis; aspartic acid; biomarkers; biosynthesis; carcinoma; cell lines; cysteine; drugs; gas chromatography-mass spectrometry; glutamic acid; glutamine; glutathione; lipid metabolism; metabolites; metabolome; metabolomics; methionine; neoplasm cells; patients; serine; stearic acid; therapeutics; threonine
Abstract:
... Although a majority of nasopharyngeal carcinoma (NPC) are undifferentiated and strongly radiosensitive, many NPC patients still have troubles in recurrence. Traditional Chinese medicine (TCM) is considered as potential therapeutic drugs in NPC. However, the effect of Glycyrrhiza glabra on NPC is limited. The present study shows the decreased proliferation and high apoptosis in G. glabra root extra ...
DOI:
10.1007/s11033-019-04828-1

38. A mitochondria targeting artesunate prodrug-loaded nanoparticle exerting anticancer activity via iron-mediated generation of the reactive oxygen species

Author:
Zhigang Chen; Xiaoxu Kang; Yixin Wu; Haihua Xiao; Xuzi Cai; Shihou Sheng; Xuefeng Wang; Shiguo Chen
Source:
Chemical communications 2019 v.55 no.33 pp. 4781-4784
ISSN:
1364-548X
Subject:
antineoplastic activity; chemical compounds; chemical reactions; mitochondria; nanoparticles; reactive oxygen species
Abstract:
... An artesunate anticancer prodrug with a long aliphatic chain N,N′-bis(dodecyl)-l-glutamic diamide was developed into nanoparticle via iron-mediated ROS generation. ...
DOI:
10.1039/c9cc00531e

39. A mitochondria-targeted delivery system of doxorubicin and evodiamine for the treatment of metastatic breast cancer

Author:
Xiaoyan Tan; Yanlin Zhou; Li Shen; Han Jia; Xiaorong Tan
Source:
RSC advances 2019 v.9 no.63 pp. 37067-37078
ISSN:
2046-2069
Subject:
antineoplastic activity; breast neoplasms; cell growth; disulfides; doxorubicin; metastasis; micelles; mitochondria; mitochondrial membrane; neoplasm cells; therapeutics
Abstract:
... For mitochondria-targeted nano-drug delivery systems against cancer, effectively targeting and releasing the drug into mitochondria are the keys to improve the therapeutic effect. In this study, mitochondria-targeted and reduction-sensitive micelles were developed to co-deliver doxorubicin (DOX) and evodiamine (EVO) for the treatment of metastatic breast cancer. After entering cancer cells, the mi ...
DOI:
10.1039/c9ra07096f

40. A modified method for purification of N-acetylgalactosamine specific lectin from Butea monosperma seeds and its effect on human hepatocellular carcinoma cell growth

Author:
Kavita Y. Hiremath; Prajna Hegde; Mamta Sharma; Shashikala R. Inamdar
Source:
Journal of plant biochemistry and biotechnology 2019 v.28 no.4 pp. 397-404
ISSN:
0971-7811
Subject:
Ayurvedic medicine; Butea monosperma; Psophocarpus tetragonolobus; affinity chromatography; antineoplastic activity; cell growth; galactose; haptens; hepatoma; human cell lines; humans; lactose; lectins; legumes; medicinal plants; neoplasm cells; polyacrylamide gel electrophoresis; seeds; toxicity testing
Abstract:
... Butea monosperma is a medicinal plant extensively used in ayurveda and is known for its medicinal applications. Butea monosperma seed powder is used for treating various health ailments including cancer. Although, most parts of the plant are being used in medicine none of them except for seeds are known to contain lectins. A lectin from seeds has been reported earlier, however it was not tested fo ...
DOI:
10.1007/s13562-019-00488-1

41. A near infrared light-triggered human serum albumin drug delivery system with coordination bonding of indocyanine green and cisplatin for targeting photochemistry therapy against oral squamous cell cancer

Author:
Yuxin Wang; Diya Xie; Jiongru Pan; Chengwan Xia; Lei Fan; Yumei Pu; Qian Zhang; Yan hong Ni; Jianquan Wang; Qingang Hu
Source:
Biomaterials science 2019 v.7 no.12 pp. 5270-5282
ISSN:
2047-4849
Subject:
antineoplastic activity; blood serum; cisplatin; cysteine; cytotoxicity; drug delivery systems; endocytosis; fibroblasts; human serum albumin; humans; nanoparticles; near-infrared spectroscopy; neoplasm cells; photochemistry; photochemotherapy; photothermotherapy; protein secretion; reactive oxygen species; squamous cell carcinoma; synergism
Abstract:
... To ensure site–specific drug delivery/release in tumor cells and cancer-associated fibroblasts (CAFs) and reduce the systemic toxicity of chemotherapy, a novel drug delivery system called human serum albumin-indocyanine green-cisplatin nanoparticles (HSA-ICG-DDP NPs) was developed in our study. We characterized this system in vitro and in vivo and showed synergistic effects with photodynamic thera ...
DOI:
10.1039/c9bm01192g

42. A new abietane diterpenoid glycoside from ajuga ovalifolia var. calantha

Author:
Fan Yang; Hong-Ping Chen; Xiao-Fei Shen; Hu-Lan Chen; Yin Chen; Li-Xia Wang; Hai Zhang; Wen-Ji Zhao; Mei Zhang; Yu-Zhu Tan
Source:
Natural product research 2019 v.33 no.19 pp. 2856-2859
ISSN:
1478-6427
Subject:
Ajuga; antineoplastic activity; cytotoxicity; diterpenoids; glycosides; human cell lines; inhibitory concentration 50; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... A new abietane diterpenoid glycoside, ajugaside B (1), along with three known compounds (2–4), were isolated from the whole plants of Ajuga ovalifolia var. calantha. The structure of the new compound (1) was elucidated by means of spectroscopic analyses (HRESIMS, IR, NMR and ECD). All of the isolated compounds were evaluated for their antitumor activities against MGC803, MCF-7, A549, HT29 and HepG ...
DOI:
10.1080/14786419.2018.1500574

43. A new dithiolopyrrolone antibiotic triggered by a long fermentation of Saccharothrix algeriensis NRRL B‐24137 in sorbic acid‐amended medium

Author:
R. Merrouche; A. Yekkour; Y. Coppel; N. Bouras; A. Zitouni; A. Lebrihi; F. Mathieu; N. Sabaou
Source:
Letters in applied microbiology 2019 v.69 no.4 pp. 294-301
ISSN:
0266-8254
Subject:
Gram-positive bacteria; Saccharothrix; antibiotics; antifungal properties; antineoplastic activity; bioactive compounds; biosynthesis; chemical structure; culture media; fermentation; high performance liquid chromatography; magnetism; minimum inhibitory concentration; soil; sorbic acid; spectroscopy; therapeutics; yeasts
Abstract:
... Saccharothrix algeriensis NRRL B‐24137 is an actinobacterium isolated from Algerian Saharan soil. It produces bioactive compounds belonging to the dithiolopyrrolone class of antibiotics, which are characterized by the possession of a unique pyrrolinonodithiole nucleus. Dithiolopyrrolones are known for their strong antibacterial and antifungal activities. This class of antibiotics generated great i ...
DOI:
10.1111/lam.13207

44. A new drug carrier with oxygen generation function for modulating tumor hypoxia microenvironment in cancer chemotherapy

Author:
Zhe Zhang; Na Niu; Xi Gao; Fuqin Han; Zhijun Chen; Shujun Li; Jian Li
Source:
Colloids and surfaces 2019 v.173 pp. 335-345
ISSN:
0927-7765
Subject:
antineoplastic activity; antineoplastic agents; colloids; drug resistance; drug therapy; gold; hypoxia; iron oxides; irradiation; magnetic fields; magnetic materials; nanocarriers; neoplasm cells; neoplasms; oxygen; oxygen production; pH; porous media; reactive oxygen species; silica
Abstract:
... Hypoxia is the main characteristic of tumor microenvironment, and the one of the key factors that cause the drug resistance of cancer cells for chemotherapy. Anticancer drug such as DOX cannot react with sufficient oxygen to produce reactive oxygen species (ROS) in hypoxic environment, which affects the therapeutic efficiency of the drug. In this work, we constructed a multi-functional nano-carrie ...
DOI:
10.1016/j.colsurfb.2018.10.008

45. A new glycoprotein SPG-8700 isolated from sweet potato with potential anti-cancer activity against colon cancer

Author:
Cheng Tian; Meimei Wang; Shanshan Liu; Hang Ma; Kai He; Deqi Zhou; Yanlin Li; Xiaoli Ye; Xuegang Li
Source:
Natural product research 2019 v.33 no.16 pp. 2322-2328
ISSN:
1478-6427
Subject:
Western blotting; amino acids; antineoplastic activity; apoptosis; arabinose; colorectal neoplasms; desorption; flow cytometry; galactose; glucose; glucuronic acid; glycoproteins; high performance liquid chromatography; mannose; mass spectrometry; molecular weight; protein content; rhamnose; sweet potatoes
Abstract:
... A new small molecule glycoprotein SPG-8700 with potential anti-colorectal cancer activity was firstly separated by tracking of bioactivity from a new sweet potato variety Zhongshu-1. Matrix-assisted laser desorption ionization mass spectrometry, high-performance liquid chromatography and amino acid analyzer were applied separately to determine the molecular weight and compositions of this glycopro ...
DOI:
10.1080/14786419.2018.1446007

46. A novel anti-cancer mechanism of Nutlin-3 through downregulation of Eag1 channel and PI3K/AKT pathway

Author:
Xuzhao Wang; Yafei Chen; Hui Liu; Shuai Guo; Yufeng Hu; Yong Zhan; Hailong An
Source:
Biochemical and biophysical research communications 2019 v.517 no.3 pp. 445-451
ISSN:
0006-291X
Subject:
antineoplastic activity; cell viability; electrophysiology; human cell lines; research
Abstract:
... Nutlin-3 shows a potent antitumor efficacy through downregulation of the cancerogenic ether à go-go 1 (Eag1) channel. However, the molecular mechanisms responsible for the regulation of Eag1 by Nutlin-3 in cancer cells remain unclear. In this study, we propose a novel anticancer mechanism of Nutlin-3, in which Nutlin-3 acts through the p53-Eag1-PI3K/AKT pathway. We first confirmed that Eag1 was do ...
DOI:
10.1016/j.bbrc.2019.07.106

47. A novel antibody-drug conjugate, HcHAb18-DM1, has potent anti-tumor activity against human non-small cell lung cancer

Author:
Muren Huhe; Jiaxin Lou; Yumeng Zhu; Yu Zhao; Ying Shi; Bo Wang; Xiuxuan Sun; Xiaoqin Zhang; Yang Zhang; Zhi-Nan Chen
Source:
Biochemical and biophysical research communications 2019 v.513 no.4 pp. 1083-1091
ISSN:
0006-291X
Subject:
antineoplastic activity; cell cycle checkpoints; cell lines; cytotoxicity; drugs; epidermal growth factor receptors; humans; immunoglobulins; in vitro studies; lung neoplasms; mice; microtubules; mitotic spindle apparatus; monoclonal antibodies; patients; therapeutics; transmembrane proteins
Abstract:
... Cluster of differentiation 147 (CD147), a transmembrane protein of the immunoglobulin superfamily, is a potential target of treatment against human non-small cell lung cancer (NSCLC). Although there have been exciting advances in epidermal growth factor receptor (EGFR)-targeted therapy for NSCLC in recent years, additional novel targeted agents are needed to improve the efficiency and to offer mor ...
DOI:
10.1016/j.bbrc.2019.04.046

48. A novel antioxidant rich compound 2-hydoxy 4-methylbenzaldehyde from Decalepis arayalpathra induces apoptosis in breast cancer cells

Author:
Ramar Thangam; Sivaraman Gokul; Malairaj Sathuvan; Veeraperumal Suresh; Srinivasan Sivasubramanian
Source:
Biocatalysis and agricultural biotechnology 2019 v.21 pp. 101339
ISSN:
1878-8181
Subject:
Apocynaceae; DNA fragmentation; antineoplastic activity; apoptosis; benzaldehyde; bioavailability; breast neoplasms; cell cycle checkpoints; chemical constituents of plants; cytotoxicity; distillation; medicinal plants; membrane potential; neoplasm cells; nuclear genome; reactive oxygen species; traditional medicine
Abstract:
... Decalepis arayalpathra is an endangered and endemic medicinal plant, mainly used for its aromatic and ethno-medical properties. In this study, we reported the biomedical potentials of 2-hydoxy 4-methylbenzaldehyde (2H4MB) from D. arayalpathra. The compound 2H4MB was isolated from fresh root barks of the plants using steam-hydro distillation extraction method and quantified using HPLC analysis, whi ...
DOI:
10.1016/j.bcab.2019.101339

49. A novel mechanism of irinotecan targeting MDM2 and Bcl-xL

Author:
Boah Lee; Jeong A. Min; Abdullateef Nashed; Sang-Ok Lee; Jae Cheal Yoo; Seung-Wook Chi; Gwan-Su Yi
Source:
Biochemical and biophysical research communications 2019 v.514 no.2 pp. 518-523
ISSN:
0006-291X
Subject:
DNA topoisomerase; antineoplastic activity; antineoplastic agents; binding capacity; binding sites; colorectal neoplasms; mechanism of action; metabolites; models; neoplasm cells; nuclear magnetic resonance spectroscopy; pro-apoptotic proteins; proteins; ubiquitin-protein ligase
Abstract:
... Irinotecan is a strong anticancer drug whose mechanism of action has been reported only for the inhibition of DNA topoisomerase I (Topo I) through its active metabolite SN-38. In this study, we present a new mechanism of Irinotecan which inhibits the activities of MDM2, an E3 ligase of tumour suppressor p53, and Bcl-xL, an anti-apoptotic protein, through direct binding. In our structure modelling ...
DOI:
10.1016/j.bbrc.2019.04.009

50. A novel metalloprotease from banana peel and its biochemical characterization

Author:
Poorani Gurumallesh; Baskar Ramakrishnan; Bhaarathi Dhurai
Source:
International journal of biological macromolecules 2019 v.134 pp. 527-535
ISSN:
0141-8130
Subject:
antineoplastic activity; apoptosis; banana peels; bananas; collagen; cytotoxicity; detergents; enzyme activity; fluorescent dyes; industry; metal ions; metalloproteinases; molecular weight; pH; peptides; salinity; screening; solvents; therapeutics
Abstract:
... Protein cleaving enzymes, called proteases are one of the most commercially used enzymes possessing extensive applications in various industries. The present study was focused on screening, extraction, purification and characterization of protease from banana peel. Twelve different varieties of banana peels were screened for the protease activity. The maximum activity of the isolated enzyme was 23 ...
DOI:
10.1016/j.ijbiomac.2019.05.051