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You searched for: Publication Year 2019 Remove constraint Publication Year: 2019 Subject term antineoplastic agents Remove constraint Subject term: antineoplastic agents Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. 1,5-Diaminonaphthalene functionalized carbon nanodots as a novel matrix for the analysis of small molecules by matrix-assisted laser desorption/ionization mass spectrometry

Author:
Yueying Zhang; Dan Gao; Shangfu Li; Weili Wei; Jinshun Lin; Yuyang Jiang
Source:
Analytical methods 2019 v.11 no.8 pp. 1131-1136
ISSN:
1759-9679
Subject:
amino acids; antineoplastic agents; carbon; desorption; detection limit; dopamine; fatty acids; mass spectrometry; nanotechnology; salt tolerance
Abstract:
... 1,5-Diaminonaphthalene functionalized carbon nanodots (DAN-CDs) were explored as a novel matrix for direct detection of small molecules by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) in negative ion mode. By using DAN-CDs as the matrix, we could detect not only biological small molecules such as fatty acids (FAs), amino acids, peptide Gly–Gly and dopamine, but also ant ...
DOI:
10.1039/c8ay02665c

2. 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone induced apoptosis and G1 cell cycle arrest through PI3K/AKT pathway in BEL-7402/5-FU cells

Author:
Xiang Ji; Xing Wei; Jie Qian; Xuejun Mo; Guoyin Kai; Faliang An; Yanhua Lu
Source:
Food and chemical toxicology 2019 v.131 pp. 110533
ISSN:
0278-6915
Subject:
Syzygium nervosum; antineoplastic agents; apoptosis; buds; cell cycle checkpoints; chalcone; cyclins; cytotoxicity; growth retardation; hepatoma; multiple drug resistance; therapeutics; toxicology; transcription factor NF-kappa B
Abstract:
... Hepatocellular carcinoma is the fifth most common and the third most lethal cancer worldwide. In recent years, natural flavonoids have drawn great attention as repository for the exploitation of novel antineoplastic agents. 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC), a functional chalcone isolated from the buds of Cleistocalyx operculatus, has been reported to exert potent cytotoxicit ...
DOI:
10.1016/j.fct.2019.05.041

3. 2′-Hydroxyflavanone induced changes in the proteomic profile of breast cancer cells

Author:
Lokesh D. Nagaprashantha; Jyotsana Singhal; Shireen Chikara; Gabriel Gugiu; David Horne; Sanjay Awasthi; Ravi Salgia; Sharad S. Singhal
Source:
Journal of proteomics 2019 v.192 pp. 233-245
ISSN:
1874-3919
Subject:
antineoplastic activity; antineoplastic agents; breast neoplasms; breasts; citrus fruits; epithelial cells; flavonoids; metastasis; neoplasm cells; proteins; proteomics; therapeutics; women
Abstract:
... In spite of rapid advances in understanding of signaling networks associated with the incidence and therapeutic-sensitivity, breast cancer (BC) still remains the most commonly diagnosed and prevalent cancer in women. Emergence of resistance to hormonal interventions in estrogen-receptor (ER) positive BC coupled to loss of ER expression and activation of ER-independent growth factor, heat-shock, MY ...
DOI:
10.1016/j.jprot.2018.09.005

4. 3D cell coculture tumor model: A promising approach for future cancer drug discovery

Author:
Xin Xin; Hopen Yang; Fengli Zhang; Shang-Tian Yang
Source:
Process biochemistry 2019 v.78 pp. 148-160
ISSN:
1359-5113
Subject:
antineoplastic agents; carcinogenesis; coculture; endothelial cells; fibroblasts; models; neoplasm cells; neoplasms; screening; stromal cells
Abstract:
... It is recognized that tumors do not exist and grow as isolated entities of neoplastic cells, but rather in continuous and bidirectional communication with adjacent stromal cells. Stromal cellular components, like fibroblasts, endothelial cells and multiple immune cells, have been proven to play critical roles in tumor development. In the past decade, a variety of in vitro three-dimensional (3D) tu ...
DOI:
10.1016/j.procbio.2018.12.028

5. 3D cell-based biosensor for cell viability and drug assessment by 3D electric cell/matrigel-substrate impedance sensing

Author:
Yuxiang Pan; Ning Hu; Xinwei Wei; Lin Gong; Bin Zhang; Hao Wan; Ping Wang
Source:
Biosensors & bioelectronics 2019 v.130 pp. 344-351
ISSN:
0956-5663
Subject:
antineoplastic agents; biosensors; cell culture; cell proliferation; cell viability; electrodes; hepatoma; humans; image analysis; monitoring; screening; staining; toxicity
Abstract:
... Preclinical efficacy and toxicity assessment of drug candidates plays a significant role in drug discovery and development. Traditional planar cell culture is a common way to perform the preclinical drug test, but it is difficult to correctly predict the drug efficacy and toxicity due to the simple two-dimensional (2D) extracellular microenvironment. Compared to the planar cell culture, three-dime ...
DOI:
10.1016/j.bios.2018.09.046

6. 4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer

Author:
Zhicong Zhao; Dongsheng Shang; Lipeng Qiu; Chang Guo; Yanyan Li; Hanqing Liu; Guoyue Yuan; Zhigang Tu
Source:
Life sciences 2019 v.238 pp. 116973
ISSN:
0024-3205
Subject:
DNA damage; antineoplastic activity; antineoplastic agents; cell senescence; drug therapy; enzymes; fluorescent antibody technique; heterocyclic nitrogen compounds; in vitro studies; in vivo studies; mice; screening; signal transduction; staining; stomach neoplasms; survival rate
Abstract:
... Gastric cancer (GC) is a common cancer with a relatively low survival rate. Cellular senescence, a potent anti-cancer mechanism, is naturally occurred, and can be induced by chemotherapeutic agents. We sought to explore new compounds against GC cells by inducing cellular senescence.Primary screening of a library of N-heterocyclic compounds identified some with potent inhibitory effects on GC cells ...
DOI:
10.1016/j.lfs.2019.116973

7. 5-Acetamido-1-(methoxybenzyl) isatin inhibits tumor cell proliferation, migration, and angiogenesis

Author:
Qian Zhang; Ying Fu; Yufan Zhao; Shanshan Cui; Jing Wang; Fengxi Liu; Yuan Yuan; Hervé Galons; Peng Yu; Yuou Teng
Source:
RSC advances 2019 v.9 no.63 pp. 36690-36698
ISSN:
2046-2069
Subject:
angiogenesis; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cell proliferation; chemotaxis; cyclins; flow cytometry; human umbilical vein endothelial cells; humans; indoles; liver neoplasms; mitochondria; neoplasm cells
Abstract:
... Indole and its derivatives are widely distributed in both animals and plants. Among its array of biological activities, the anti-tumor activity of indole has garnered much attention. Furthermore, the synthesis and activity of indole derivatives, including isatin, constitute a flourishing research topic. Previously, many isatin derivatives were synthesized by our group, and 5-acetamido-1-(methoxybe ...
DOI:
10.1039/c9ra07002h

8. AIE/FRET-based versatile PEG-Pep-TPE/DOX nanoparticles for cancer therapy and real-time drug release monitoring

Author:
Tian-Tian Wang; Qi-Chun Wei; Zhen-Tao Zhang; Meng-Ting Lin; Jie-Jian Chen; Yi Zhou; Ning-Ning Guo; Xin-Cheng Zhong; Wen-Hong Xu; Zhan-Xiang Liu; Min Han; Jian-Qing Gao
Source:
Biomaterials science 2019 v.8 no.1 pp. 118-124
ISSN:
2047-4849
Subject:
antineoplastic agents; cancer therapy; cell death; energy transfer; fluorescence; microfilaments; monitoring; nanomedicine; nanoparticles; neoplasms; polyethylene; polypeptides
Abstract:
... On account of the biological significance of self-assembling peptides in blocking the cellular mass exchange as well as impeding the formation for actin filaments resulting in program cell death, stimuli-responsive polypeptide nanoparticles have attracted more and more attention. In this work, we successfully fabricated doxorubicin-loaded polyethylene glycol-block-peptide (FFKY)-block-tetraphenyle ...
DOI:
10.1039/c9bm01546a

9. AS1411 aptamer-modified theranostic liposomes co-encapsulating manganese oxide nano-contrast agent and paclitaxel for MRI and therapy of cancer

Author:
Jingjing Li; Qing Li; Meijuan He; Fan Ding; Lulu Cai; Mingming Zhao; Lina Dong; Qi Wang; Kai Xu
Source:
RSC advances 2019 v.9 no.60 pp. 34837-34846
ISSN:
2046-2069
Subject:
antineoplastic agents; carcinoma; growth retardation; magnetic resonance imaging; manganese monoxide; nanocarriers; nanoparticles; oligonucleotides; paclitaxel; polyethylene glycol
Abstract:
... With the advantages and development of MRI nano-contrast agents (CAs), increasing number of MRI-based theranostic nanoparticles have emerged. Liposome, as a biosafe nanocarrier has been used phase III trial for cancer treatment. In this study, liposome was employed as a nanocarrier to co-encapsulate MRI nano-contrast agent poly(ethylene glycol)-grafted manganese oxide (PEG-MnO) and anticancer drug ...
DOI:
10.1039/c9ra06878c

10. Acid ceramidase, an emerging target for anti-cancer and anti-angiogenesis

Author:
Sung Min Cho; Ho Jeong Kwon
Source:
Archives of pharmacal research 2019 v.42 no.3 pp. 232-243
ISSN:
0253-6269
Subject:
G-protein coupled receptors; G-proteins; angiogenesis; antineoplastic agents; apoptosis; ceramides; glucosylceramides; human diseases; humans; metabolism; metabolites; mitogen-activated protein kinase; neoplasms; signal transduction; sphingomyelins; sphingosine; therapeutics
Abstract:
... Sphingolipid metabolism plays an important role in determining the fate of a cell. Among several sphingolipid metabolites, ceramide is a key player in intracellular signal transduction. Ceramide is usually converted to various metabolites such as sphingomyelin, sphingosine, ceramide-1-phosphate, and glucosylceramide. If ceramide is accumulated in the cell, it induces apoptosis. On the other hand, ...
DOI:
10.1007/s12272-019-01114-3

11. Aclarubicin regulates glioma cell growth and DNA damage through the SIRT1/PI3K/AKT signaling pathway

Author:
Jun-feng Huo; Xiao-bing Chen
Source:
RSC advances 2019 v.9 no.49 pp. 28775-28782
ISSN:
2046-2069
Subject:
DNA damage; antineoplastic agents; apoptosis; caspase-3; cell growth; cell proliferation; cell viability; gene overexpression; glioma; phosphatidylinositol 3-kinase; phosphorylation; rats; signal transduction; therapeutics
Abstract:
... Aclarubicin (ACR), an anthracycline anti-tumor agent, is known to play important roles in cancer. Evidence has suggested that ACR has therapeutic effects on rats intracranially implanted with C6 glioma cells. However, the function and mechanism of ACR in glioma cells remain elusive. In this study, we examined the effects of ACR on glioma cell growth, apoptosis, and DNA damage. Our results showed t ...
DOI:
10.1039/c9ra05572j

12. Activity-based protein profiling reveals GSTO1 as the covalent target of piperlongumine and a promising target for combination therapy for cancer

Author:
Li Li; Yue Zhao; Ran Cao; Lin Li; Gaihong Cai; Jiaojiao Li; Xiangbing Qi; She Chen; Zhiyuan Zhang
Source:
Chemical communications 2019 v.55 no.30 pp. 4407-4410
ISSN:
1364-548X
Subject:
antineoplastic agents; cell death; chemical compounds; chemical reactions; neoplasm cells; neoplasms; protein composition; screening; therapeutics
Abstract:
... Through systematic target identification for piperlongumine, a cancer-selective killing molecule, we identified GSTO1 as its major covalent target for cancer cell death induction. We also reveal that GSTO1 inhibition is a promising combination strategy with other anti-cancer agents by drug combination screening in which piperlongumine exhibits broad-spectrum synergistic effects with a large propor ...
DOI:
10.1039/c9cc00917e

13. Advances in chitosan-based nanoparticles for oncotherapy

Author:
Enhui Zhang; Ronge Xing; Song Liu; Yukun Qin; Kecheng Li; Pengcheng Li
Source:
Carbohydrate polymers 2019 v.222 pp. 115004
ISSN:
0144-8617
Subject:
DNA; antineoplastic agents; biocompatibility; biodegradability; chitosan; drug carriers; drug therapy; nanoparticles; neoplasms; photosensitizing agents; proteins; small interfering RNA; tissues
Abstract:
... Chitosan has attracted considerable attention as an anti-tumor drug carrier material in recent years, which is due to its biocompatibility and biodegradability, as well as the simple and mild preparing techniques of drug-loaded nanoparticles. Chitosan-based nanoparticles can deliver various anti-tumor agents to specific tumor tissues by passive and active targeting mechanisms, including traditiona ...
DOI:
10.1016/j.carbpol.2019.115004

14. Adverse drug reactions of anticancer drugs derived from natural sources

Author:
Devesh Tewari; Pooja Rawat; Pawan Kumar Singh
Source:
Food and chemical toxicology 2019 v.123 pp. 522-535
ISSN:
0278-6915
Subject:
adverse effects; alopecia; antineoplastic agents; cardiotoxicity; chemical structure; drug toxicity; herbal medicines; information retrieval; mechanism of action; microorganisms; neurotoxicity; prediction; systematic review
Abstract:
... Cancer, a life threatening disease adversely affects huge population worldwide. Naturally derived drug discovery has emerged as a potential pathway in search of anticancers. Natural products-based drugs are generally considered safe, compared to their synthetic counterparts. A systematic review on adverse drugs reactions (ADRs) of the anticancer natural products has not been performed till date. W ...
DOI:
10.1016/j.fct.2018.11.041

15. Ageing alters the severity of Sunitinib-induced cardiotoxicity: Investigating the mitogen activated kinase kinase 7 pathway association

Author:
Samantha Cooper; Hardip Sandhu; Afthab Hussain; Christopher Mee; Helen Maddock
Source:
Toxicology 2019 v.411 pp. 49-59
ISSN:
0300-483X
Subject:
Western blotting; antineoplastic agents; cardiac output; cardiotoxicity; enzymes; gene expression; heart; heart rate; infarction; laboratory animals; males; messenger RNA; microRNA; mitogens; models; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction
Abstract:
... Anti-cancer drug Sunitinib is linked to adverse cardiovascular events, which have shown to involve mitogen activated kinase kinase 7 (MKK7) pathway. Sunitinib-induced cardiotoxicity in 3, 12 and 24 months old male Sprague-Dawley rats and MKK7 expression and activation was investigated using the Langendorff perfused heart model followed by Western blot analysis. Cardiac function and infarct size we ...
DOI:
10.1016/j.tox.2018.10.016

16. Albumin-Modified Cationic Nanocarriers To Potentially Create a New Platform for Drug Delivery Systems

Author:
Zhicheng Pan; Xueling He; Nijia Song; Danxuan Fang; Zhen Li; Jiehua Li; Feng Luo; Jianshu Li; Hong Tan; Qiang Fu
Source:
ACS applied materials & interfaces 2019 v.11 no.18 pp. 16421-16429
ISSN:
1944-8252
Subject:
adverse effects; albumins; antineoplastic agents; bioavailability; biosecurity; macrophages; micelles; nanocarriers; nanoparticles; neoplasm cells; neoplasms; nucleic acids; polymers; protein corona; tissues; toxicity
Abstract:
... Cationic nanocarriers have emerged as promising nanoparticle systems for the effective delivery of nucleic acid and anticancer drugs to cancer cells. A positive charge is desirable for promoting cell internalization, whereas it also causes some adverse effects, such as toxicity and rapid clearance by mononuclear phagocytic systems. Herein, a new strategy of modifying cationic polymer micelles with ...
DOI:
10.1021/acsami.9b05599

17. Alkaloids from nux vomica suppresses colon cancer cell growth through Wnt/β‐catenin signaling pathway

Author:
Hua Ren; Jianping Zhao; Dongsheng Fan; Ze Wang; Tingjie Zhao; Yuejin Li; Yirui Zhao; David Adelson; Huiqin Hao
Source:
Phytotherapy research 2019 v.33 no.5 pp. 1570-1578
ISSN:
0951-418X
Subject:
Strychnos; antineoplastic agents; apoptosis; beta catenin; cell growth; colorectal neoplasms; flow cytometry; humans; mice; neoplasm cells; seeds; signal transduction; strychnine; tissues; traditional medicine
Abstract:
... Brucine and Strychnine are alkaloids isolated from the seeds of Strychnos nux vomica L., which have long been used as a traditional medicine for the treatment of tumor. However, the effect of Brucine and Strychnine on colorectal cancer (CRC) and the underlying molecular mechanism remain unclear. In the present study, Brucine and Strychnine displayed profound inhibitory effects on the growth of hum ...
DOI:
10.1002/ptr.6347

18. Allium vegetables for possible future of cancer treatment

Author:
Yahya Asemani; Nasrindokht Zamani; Maryam Bayat; Zahra Amirghofran
Source:
Phytotherapy research 2019 v.33 no.12 pp. 3019-3039
ISSN:
0951-418X
Subject:
Allium; adverse effects; ajoene; antineoplastic activity; antineoplastic agents; antioxidant activity; apoptosis; cell cycle; chives; garlic; health effects assessments; ingredients; leeks; medicinal plants; metastasis; neoplasm cells; neoplasms; quercetin; shallots; signal transduction; sulfur; therapeutics; traditional medicine
Abstract:
... Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, onions, leeks, chives, and shallots. These plants have been exploited in folk medicine because of their beneficial health effects in improving numerou ...
DOI:
10.1002/ptr.6490

19. Alternative and Injectable Preformed Albumin-Bound Anticancer Drug Delivery System for Anticancer and Antimetastasis Treatment

Author:
Chuchu Zhou; Xu Song; Chenqi Guo; Yulu Tan; Juan Zhao; Qin Yang; Dan Chen; Tiantian Tan; Xun Sun; Tao Gong; Zhirong Zhang
Source:
ACS applied materials & interfaces 2019 v.11 no.45 pp. 42534-42548
ISSN:
1944-8252
Subject:
antineoplastic agents; biomimetics; chemical reactions; cytotoxicity; dissociation; drug delivery systems; films (materials); half life; human serum albumin; intravenous injection; nanoparticles; neoplasms; paclitaxel; patients; pharmacokinetics
Abstract:
... Biomimetic design has been extensively investigated. The only FDA-approved biomimetic albumin-bound paclitaxel may not be beneficial to some treated patients due to rapid dissociation upon intravenous infusion and no substantial improvement in the drug’s pharmacokinetics or biodistribution. Herein, we developed an alternative and injectable preformed albumin-bound anticancer drug delivery. We comb ...
DOI:
10.1021/acsami.9b11307

20. Amphipathic Nanodiamond Supraparticles for Anticancer Drug Loading and Delivery

Author:
Yue Yu; Xi Yang; Ming Liu; Masahiro Nishikawa; Takahiro Tei; Eijiro Miyako
Source:
ACS applied materials & interfaces 2019 v.11 no.21 pp. 18978-18987
ISSN:
1944-8252
Subject:
antineoplastic agents; carboxylic acids; dispersibility; drug carriers; drug therapy; hydrophobicity; nanodiamonds; nanomedicine; nanoparticles; paclitaxel; particle size; polyethylene glycol; sonication; spectroscopy; surfactants
Abstract:
... Nanodiamonds (NDs) have been attracting considerable attention due to their outstanding chemical, physical, and physiological properties. Additional functionalization of NDs can be carried out by the self-assembly technique. This study reports a straightforward chemical route for self-assembled supraparticles (SPs) based on ND (ND–SPs) using alkyl carboxylic acids with different aliphatic alkyl ch ...
DOI:
10.1021/acsami.9b04792

21. Amphipathic β-cyclodextrin nanocarriers serve as intelligent delivery platform for anticancer drug

Author:
Hui Liu; Jian Chen; Xiufang Li; Zhiwei Deng; Peiru Gao; Jianbin Li; Tao Ren; Ling Huang; Yanjing Yang; Shian Zhong
Source:
Colloids and surfaces 2019 v.180 pp. 429-440
ISSN:
0927-7765
Subject:
antineoplastic agents; beta-cyclodextrin; cytotoxicity; disulfide bonds; hydrophilicity; hydrophobicity; moieties; nanocarriers; polymers; surfactants
Abstract:
... A novel glutathione-responsive (GSH-responsive) star-like amphiphilic polymer (C12H25)14-β-CD-(S-S-mPEG)7 (denoted as CCSP) was designed for efficient antitumor drug delivery. The amphiphilic β-cyclodextrin (β-CD) self-polymerize in water to form a sphere with a diameter of 40–50 nm. The secondary hydroxyl groups of β-CD were modified by dodecyl to form a hydrophobic core and the primary hydroxyl ...
DOI:
10.1016/j.colsurfb.2019.05.011

22. Amphiphilic carboxylated cellulose-g-poly(l-lactide) copolymer nanoparticles for oleanolic acid delivery

Author:
Yingsa Wang; Pengbo Zhu; Guiliang Li; Shangbin Zhu; Kefeng Liu; Yanxue Liu; Jing He; Jiandu Lei
Source:
Carbohydrate polymers 2019 v.214 pp. 100-109
ISSN:
0144-8617
Subject:
Fourier transform infrared spectroscopy; antineoplastic agents; biomass; carboxylation; cellulose; composite polymers; cytotoxicity; hydrophilicity; in vivo studies; nanocrystals; nanoparticles; nuclear magnetic resonance spectroscopy; oleanolic acid; polymerization; solvents; thermogravimetry; water solubility
Abstract:
... Carboxylated cellulose nanocrystals (CCNs), as one of nanocellulose are promising hydrophilic biomass materials for drug delivery. In this work, a series of amphiphilic carboxylated cellulose-graft-Poly(L-lactide) (CC-g-PLLA) copolymers were synthesized via ring-opening polymerization (ROP) method. The copolymers were characterized by 1H-NMR, FT-IR, WXRD and TGA, and their solubility in organic so ...
DOI:
10.1016/j.carbpol.2019.03.033

23. Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from Foeniculum vulgare from Hamedan, Iran

Author:
Maryam Akhbari; Reza Kord; Saeedeh Jafari Nodooshan; Sepideh Hamedi
Source:
Natural product research 2019 v.33 no.11 pp. 1629-1632
ISSN:
1478-6427
Subject:
Artemia; Escherichia coli; Foeniculum vulgare; Pseudomonas aeruginosa; Shigella dysenteriae; antibacterial properties; antineoplastic activity; antineoplastic agents; breast neoplasms; carcinoma; cell lines; death; essential oils; gas chromatography-mass spectrometry; humans; inhibitory concentration 50; lethal concentration 50; limonene; methyl chavicol; seed oils; seeds; toxicity; Iran
Abstract:
... In this study, biological properties of the essential oil isolated from seeds of Foeniculum vulgare (F. vulgare) were evaluated. GC-MS analysis revealed Trans-Anethole (80.63%), L-Fenchone (11.57%), Estragole (3.67%) and Limonene (2.68%) were the major compounds of the essential oil. Antibacterial activity of the essential oil against nine Gram-positive and Gram-negative strains was studied using ...
DOI:
10.1080/14786419.2017.1423310

24. Analysis of 1-Deoxysphingoid Bases and Their N-Acyl Metabolites and Exploration of Their Occurrence in Some Food Materials

Author:
Junliang Wan; Jian Li; Sibali Bandyopadhyay; Samuel L. Kelly; Yang Xiang; Jin Zhang; Alfred H. Merrill; Jingjing Duan
Source:
Journal of agricultural and food chemistry 2019 v.67 no.46 pp. 12953-12961
ISSN:
1520-5118
Subject:
acyl coenzyme A; alanine; antineoplastic agents; ceramides; diet; electrospray ionization mass spectrometry; foods; glycine (amino acid); human diseases; human health; mammals; metabolites; moieties; quantitative analysis; reversed-phase liquid chromatography; serine; serine C-palmitoyltransferase; sphinganine
Abstract:
... Most common sphingolipids are comprised of “typical” sphingoid bases (sphinganine, sphingosine, and structurally related compounds) and are produced via the condensation of l-serine with a fatty acyl-CoA by serine palmitoyltransferase. Some organisms, including mammals, also produce “atypical” sphingoid bases that lack a 1-hydroxyl group as a result of the utilization of l-alanine or glycine inste ...
DOI:
10.1021/acs.jafc.9b05708

25. Anions reversibly responsive luminescent nanocellulose hydrogels for cancer spheroids culture and release

Author:
Jun Hai; Xiaofan Zeng; Yanhong Zhu; Baodui Wang
Source:
Biomaterials 2019 v.194 pp. 161-170
ISSN:
0142-9612
Subject:
anions; antineoplastic agents; cellulose; crosslinking; extracellular matrix; fluorescence; hydrogels; image analysis; neoplasms; screening; thiocyanates
Abstract:
... Artificial stimuli-responsive hydrogels that can mimic natural extracellular matrix for growth and release of cancer spheroids (CSs) have attracted much attention. However, such hydrogels still face a challenge in regulating CSs growth and controlled release as well as keeping CSs integrity. Herein, a new class of ClO−/SCN− reversibly responsive nanocellulose hydrogel with fluorescence on-off repo ...
DOI:
10.1016/j.biomaterials.2018.12.016

26. Anodic Electrochemiluminescence of Carbon Dots Promoted by Nitrogen Doping and Application to Rapid Cancer Cell Detection

Author:
Anyi Chen; Wenbin Liang; Haijun Wang; Ying Zhuo; Yaqin Chai; Ruo Yuan
Source:
Analytical chemistry 2019 v.92 no.1 pp. 1379-1385
ISSN:
1520-6882
Subject:
antineoplastic agents; biocompatibility; biosensors; carbon quantum dots; electrochemiluminescence; electrodes; energy; hydrazides; hydrogen peroxide; monitoring; neoplasm cells; neoplasms; nitrogen; pharmacodynamics
Abstract:
... In this work, a kind of novel nitrogen doped hydrazide conjugated carbon dots (NHCDs) with strong anodic electrochemiluminescence (ECL) at a low excitation potential were synthesized via a one-step solvothermal approach and applied to construct biosensor for rapid cancer cell detection. The nitrogen doping induced a shift of the highest occupied molecular orbital (HOMO) to the upper energy level t ...
DOI:
10.1021/acs.analchem.9b04537

27. Anthryl Benzothiazolium Molecular Rotor-Based Turn-On DNA Probe: Detailed Mechanistic Studies

Author:
Bhupesh Kumar; Rajib Ghosh; Aruna K. Mora; Sukhendu Nath
Source:
Journal of physical chemistry 2019 v.123 no.35 pp. 7518-7527
ISSN:
1520-5207
Subject:
DNA; DNA probes; anthracenes; antineoplastic agents; computer simulation; emissions factor; ligands; models; moieties; molecular rotors; neoplasms; quantum mechanics; spectral analysis
Abstract:
... An efficient turn-on fluorescence probe for biomolecules not only helps in its sensitive detection but is also useful to understand the different interactions that are operating between biomolecules and probes. Polycyclic aromatic molecules are known to be strong interacting ligand for DNA and extensively studied as a model cancer drug. However, these molecules show large decrease in their emissio ...
DOI:
10.1021/acs.jpcb.9b05570

28. Anti-Inflammatory and Antiproliferative Prenylated Isoflavone Derivatives from the Fruits of Ficus carica

Author:
Yan-Ping Liu; Jia-Ming Guo; Gui Yan; Ming-Ming Zhang; Wen-Hao Zhang; Lei Qiang; Yan-Hui Fu
Source:
Journal of agricultural and food chemistry 2019 v.67 no.17 pp. 4817-4823
ISSN:
1520-5118
Subject:
Ficus carica; anti-inflammatory activity; antineoplastic agents; chemical composition; chemical structure; cortisol; figs; fruits; health promotion; human cell lines; inhibitory concentration 50; isoflavones; neoplasm cells; neoplasms; nitric oxide; spectroscopy; Middle East; West Asia
Abstract:
... Ficus carica is an Asian species of flowering plant belonging to the genus Ficus of the family Moraceae, native to Western Asia and the Middle East. Its fruits, usually known as common fig or fig, have been consumed as a very popular health-promoting fruit worldwide since ancient times. To investigate the potential health-promoting chemical constituents of the fruits of F. carica, a systematic phy ...
DOI:
10.1021/acs.jafc.9b00865

29. Anti-cancer activities of cytokinin ribosides

Author:
Jiří Voller; Tibor Béres; Marek Zatloukal; Petr Džubák; Marián Hajdúch; Karel Doležal; Thomas Schmülling; Strnad Miroslav
Source:
Phytochemistry reviews 2019 v.18 no.4 pp. 1101-1113
ISSN:
1568-7767
Subject:
antineoplastic activity; antineoplastic agents; apoptosis; cell lines; cytokinins; genes; growth and development; immune response; in vivo studies; mutants; neoplasms; patients; plant development; plant growth; plant hormones; stem cells
Abstract:
... Cytokinins are plant hormones and play essential roles in regulating plant growth and development. They also have diverse pharmacological effects in animals and humans. Whereas cytokinin bases have been studied mainly for their cytoprotective activities, cytokinin ribosides have been explored as anti-cancer agents. Cytokinin ribosides inhibit growth or cause apoptosis in various cell lines derived ...
DOI:
10.1007/s11101-019-09620-4

30. Anti-cancer effect of Indanone-based thiazolyl hydrazone derivative on colon cancer cell lines

Author:
Silpa Narayanan; Pranav Gupta; Urooj Nazim; Mohsin Ali; Nishant Karadkhelkar; Mansoor Ahmad; Zhe-Sheng Chen
Source:
international journal of biochemistry & cell biology 2019 v.110 pp. 21-28
ISSN:
1357-2725
Subject:
DNA topoisomerase; antineoplastic activity; antineoplastic agents; apoptosis; biphenyl; cell lines; colorectal neoplasms; hydrazine; hydrazones; indans; inhibitory concentration 50; mitosis; neoplasm cells; patients; polymerization; toxicity; tubulin; United States
Abstract:
... Colorectal cancer is the third leading cause of cancer related deaths in the United States. Currently, Irinotecan, a topoisomerase I inhibitor, is an approved anti-cancer drug for the treatment of patients with advanced or recurrent colorectal cancer. Considering low response rate and events of high toxicity caused by irinotecan, we evaluated a series of thirteen thiazolyl hydrazone derivatives of ...
DOI:
10.1016/j.biocel.2019.02.004

31. Anti-lung cancer activity and inhibitory mechanisms of a novel Calothrixin A derivative

Author:
Xiaohong Yang; Jiangsheng Gao; Jian Guo; Zimeng Zhao; Shao-Lin Zhang; Yun He
Source:
Life sciences 2019 v.219 pp. 20-30
ISSN:
0024-3205
Subject:
DNA topoisomerase; antineoplastic activity; antineoplastic agents; apoptosis; autophagy; caspases; cell cycle checkpoints; cell movement; cytochrome c; cytotoxicity; humans; inhibitory concentration 50; interphase; mitochondria; mitogen-activated protein kinase; models; neoplasm cells; neoplasms; plasmids
Abstract:
... CAA45 is a calothrixin A (CAA) analogue with anti-cancer activity at nanomolar concentration. This study aimed to investigate the anti-lung cancer activity of CAA45 and explore its mechanisms of actions.CAA and CAA45 were synthesized and their inhibition on DNA topoisomerase I (Topo I) performed by evaluating the relaxation of supercoiled pBR322 plasmid DNA and their anti-lung cancer capacity dete ...
DOI:
10.1016/j.lfs.2018.12.052

32. Anti-tumor properties of methoxylated analogues of resveratrol in malignant MCF-7 but not in non-tumorigenic MCF-10A mammary epithelial cell lines

Author:
Annick D. van den Brand; Judith Villevoye; Sandra M. Nijmeijer; Martin van den Berg; Majorie B.M. van Duursen
Source:
Toxicology 2019 v.422 pp. 35-43
ISSN:
0300-483X
Subject:
antineoplastic activity; antineoplastic agents; breast neoplasms; breasts; cell cycle checkpoints; cell lines; cell viability; cytochrome P-450; epithelial cells; gene expression; humans; hydroxylation; interleukin-8; mammary glands; median effective concentration; models; neoplasm cells; polyphenols; pterostilbene; reporter genes; resveratrol
Abstract:
... Resveratrol is a plant-derived polyphenol that is known for its anti-inflammatory and anti-tumorigenic properties in in vitro and in vivo models. Recent studies show that some resveratrol analogues might be more potent anti-tumor agents, which may partly be attributed to their ability to activate the aryl hydrocarbon receptor (AHR). Here, the anti-tumorigenic properties of resveratrol and structur ...
DOI:
10.1016/j.tox.2019.04.009

33. Antibacterial, antibiofilm and molecular modeling study of some antitumor thiazole based chalcones as a new class of DHFR inhibitors

Author:
Waad D. Alrohily; Mahmoud E. Habib; Shahenda M. El-Messery; Abdulmalik Alqurshi; Hussein El-Sabagh; El-Sayed E. Habib
Source:
Microbial pathogenesis 2019 pp. -
ISSN:
0882-4010
Subject:
Bacillus subtilis; Escherichia coli; Gram-negative bacteria; Gram-positive bacteria; Staphylococcus aureus; amino acids; ampicillin; antimicrobial properties; antineoplastic agents; chalcones; ciprofloxacin; computer simulation; lipophilicity; molecular models; thiazoles; toxicity
Abstract:
... Some synthesized antitumor derivatives of thiazole based chalcones including thiazolo[2,3-b]quinazoline and pyrido[4,3-d]thiazolo[3,2-a]pyrimidine analogues were subjected to be tested against standard microbial strains. Compound 18 showed higher activity against both Gram-positive and Gram-negative bacteria with MIC of 1.0, 1.0, 2.0, 2.0 and 4.0 μg/ml against S. aureus, B. subtilis, M. luteus, E. ...
DOI:
10.1016/j.micpath.2019.103674

34. Antibiotic use and duration in association with Clostridioides difficile infection in a tertiary academic medical center: A retrospective case-control study

Author:
Abrar K. Thabit; Christy A. Varugehese; Alexander R. Levine
Source:
Anaerobe 2019 v.59 pp. 126-130
ISSN:
1075-9964
Subject:
Clostridium difficile; adults; antineoplastic agents; case-control studies; cefazolin; medical facilities; microbiological risk assessment; odds ratio; patients; therapeutics
Abstract:
... Previous literature has attributed the use of certain antibiotics to Clostridioides difficile infection (CDI); however, the time from administration to CDI onset is not adequately evaluated. We aimed to determine the type of antibiotics and duration of therapy associated with the highest CDI incidence at a tertiary academic medical center. This was a retrospective, case-control study of adult inpa ...
DOI:
10.1016/j.anaerobe.2019.06.016

35. Anticancer activity of a novel glycoprotein from Camellia oleifera Abel seeds against hepatic carcinoma in vitro and in vivo

Author:
Tingting Li; Xiangyong Meng; Caie Wu; Gongjian Fan; Jing Yang; Wenting Pan
Source:
International journal of biological macromolecules 2019 v.136 pp. 284-295
ISSN:
0141-8130
Subject:
Camellia oleifera; T-lymphocytes; Western blotting; antineoplastic activity; antineoplastic agents; apoptosis; carcinoma; caspase-3; cell cycle checkpoints; chromatography; electron microscopy; flow cytometry; fluorescence microscopy; glycoproteins; human cell lines; interferon-gamma; membrane potential; mice; mitochondrial membrane; molecular weight; pancreas; pro-apoptotic proteins; seeds; thymus gland; toxicity testing
Abstract:
... Glycoproteins are naturally occurring biological macromolecule that possess known pharmacological properties. This study investigated the anticancer potential of a new glycoprotein, COG2a with the weight-average molecular weight of 25.9 kDa, isolated from Camellia oleifera Abel seeds by multiple column chromatography and the mechanism of anticancer action. MTT assay showed that the maximum inhibit ...
DOI:
10.1016/j.ijbiomac.2019.06.054

36. Anticancer activity of polymeric nanoparticles containing linoleic acid-SN38 (LA-SN38) conjugate in a murine model of colorectal cancer

Author:
Guilin Cheng; Xiaomin Zhang; Yidan Chen; Robert J. Lee; Jiangfeng Wang; Ju Yao; Yingxin Zhang; Cheng Zhang; Kaifeng Wang; Bo Yu
Source:
Colloids and surfaces 2019 v.181 pp. 822-829
ISSN:
0927-7765
Subject:
animal models; antineoplastic activity; antineoplastic agents; apoptosis; biodegradability; blood circulation; colorectal neoplasms; composite polymers; cytotoxicity; humans; in vitro studies; linoleic acid; macrophages; nanocarriers; nanoparticles; neoplasm cells; phagocytosis; polyethylene glycol; single nucleotide polymorphism; solvents; tetrahydrofuran; titration; transmission electron microscopes; transmission electron microscopy
Abstract:
... Biodegradable polymeric nanoparticles (NPs) have been used frequently as nanocarriers for anticancer drugs. Linoleic acid conjugated SN38 (LA-SN38)-loaded NPs (EBNPs) were developed using biodegradable poly (ethylene oxide)-poly (butylene oxide) (PEO-PBO) diblock copolymer by titration hydration method without using a toxic organic solvent. The EBNPs had high drug loading efficiency and entrapment ...
DOI:
10.1016/j.colsurfb.2019.06.020

37. Anticancer altretamine recognition by bovine serum albumin and its role as inhibitor of fibril formation: Biophysical insights

Author:
Ritutama Ghosh; Sonya K. Bharathkar; Nand Kishore
Source:
International journal of biological macromolecules 2019 v.138 pp. 359-369
ISSN:
0141-8130
Subject:
antineoplastic agents; binding capacity; binding sites; bovine serum albumin; circular dichroism spectroscopy; differential scanning calorimetry; fluorescence; fluorescence emission spectroscopy; light scattering; phase transition; photons; temperature
Abstract:
... Binding of anticancer drug altretamine with bovine serum albumin (BSA) and its inhibitory effect on fibrillation of the protein has been studied by using a combination of spectroscopic and calorimetric methods. Altretamine is observed to bind with BSA with a moderate binding affinity of the order of 105, which is weakly temperature dependent. Circular dichroism, fluorescence spectroscopic and dyna ...
DOI:
10.1016/j.ijbiomac.2019.07.093

38. Anticancer potential of NFκB targeting apoptotic molecule “Flavipin” isolated from endophytic Chaetomium globosum

Author:
Venugopal SenthilKumar; Subramanian Kumaresan; Manoharan Muthu Tamizh; Villianur Ibrahim Hairul Islam; Krishnaraj Thirugnanasambantham
Source:
Phytomedicine 2019 pp. 152830
ISSN:
0944-7113
Subject:
Chaetomium globosum; DNA; DNA fragmentation; Western blotting; adverse effects; antineoplastic agents; apoptosis; cell lines; cytotoxicity; dose response; endophytes; fractionation; fungi; gene expression regulation; genes; inhibitory concentration 50; metabolites; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; quantitative polymerase chain reaction; shrinkage; transcription factor NF-kappa B
Abstract:
... Anticancer compounds from natural sources have drawn attention due to their structural diversity and relatively lesser side effects. Endophytic fungi are one such natural resource from, which plethoras of anticancerous compounds have been isolated.The objective of the study was to isolate and characterize the bioactive metabolite from Chaetomium globosum that exhibits astonishing antiproliferative ...
DOI:
10.1016/j.phymed.2019.152830

39. Anticancer properties of erucin, an H2S‐releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC‐1)

Author:
Valentina Citi; Eugenia Piragine; Eleonora Pagnotta; Luisa Ugolini; Lorenzo Di Cesare Mannelli; Lara Testai; Carla Ghelardini; Luca Lazzeri; Vincenzo Calderone; Alma Martelli
Source:
Phytotherapy research 2019 v.33 no.3 pp. 845-855
ISSN:
0951-418X
Subject:
Eruca vesicaria subsp. sativa; antineoplastic activity; antineoplastic agents; apoptosis; arugula; cell cycle; cell movement; cell viability; chemoprevention; glucosinolates; humans; hydrogen sulfide; hydrolysis; isothiocyanates; mutation; neoplasm cells; pancreatic neoplasms; phosphorylation; thioglucosidase
Abstract:
... Plants of the Brassicaceae family are well‐known for containing the glucosinolate myrosinase system, which is able to release isothiocyanates after plant biotic and abiotic lesions. Erucin (ERU; 1‐isothiocyanato‐4‐(methylthio)‐butane), an isothiocyanate particularly abundant in arugula (Eruca sativa Mill., Eruca vesicaria L., etc.), derives from the hydrolysis of the glucosinolate glucoerucin by t ...
DOI:
10.1002/ptr.6278

40. Antioxidant, cytotoxicity and anti-tumor activity of Cordia dichotoma fruits accompanied with its volatile and sugar composition

Author:
Abeer Y. Ibrahim; Samah A. El-Newary; Gamil E. Ibrahim
Source:
Annals of agricultural science 2019 v.64 no.1 pp. 29-37
ISSN:
0570-1783
Subject:
Cordia dichotoma; alkaloids; alpha-phellandrene; alpha-terpineol; antineoplastic activity; antineoplastic agents; antioxidant activity; ascites; body weight; bornyl acetate; butyrates; carcinoma; catechin; chemical composition; cytotoxicity; dose response; fructose; fruit pulp; fruits; gallic acid; gas chromatography-mass spectrometry; glucose; hematologic tests; high performance liquid chromatography; ions; lethal dose 50; longevity; metals; mice; phenols; quercetin; sucrose; superoxide anion; tannins; volatile compounds
Abstract:
... The aim of the present research was to investigate the chemical composition, antioxidant and anti-tumor effects of Cordia dichotoma fruit pulp extract “CDFP-extract”. Day after intraperitoneal inoculation of Ehrlich ascites carcinoma (EAC) cells in mice, CDFP-extract was administered orally at 500 mg/kg body weight (equal to 0.10 of determined LD50) for ten consecutive days. CDFP-extract contains ...
DOI:
10.1016/j.aoas.2019.05.008

41. Antiproliferative and apoptosis-inducing potential of 3β-hydroxy-Δ5-steroidal congeners purified from the soft coral Dendronephthya putteri

Author:
Thilina U. Jayawardena; Won Woo Lee; I. P. Shanura Fernando; K. K. Asanka Sanjeewa; Lei Wang; Tee Gee Lee; Young Jin Park; Chang-Ik Ko; You-Jin Jeon
Source:
Journal of oceanology and limnology 2019 v.37 no.4 pp. 1382-1392
ISSN:
2096-5508
Subject:
DNA damage; antineoplastic agents; apoptosis; cell cycle checkpoints; chemistry; corals; dose response; fractionation; gas chromatography-mass spectrometry; human cell lines; inhibitory concentration 50; phytochemicals; secondary metabolites; signal transduction; sterols; terpenoids
Abstract:
... The exploration and identification of antiproliferative phytochemicals have received increased attention in medicinal chemistry. In particular, research focused on the toxicology of marine natural products has increased in recent years. Terpenoids, among many secondary metabolites, have been demonstrated to act as effective anticancer agents. Soft corals, a group of marine invertebrates, produce a ...
DOI:
10.1007/s00343-019-8193-y

42. Antiproliferative steroidal glycosides from rhizomes of Polygonatum sibiricum

Author:
Di Zhou; Xuezheng Li; Wenhui Chang; Yueqing Han; Bo Liu; Gang Chen; Ning Li
Source:
Phytochemistry 2019 v.164 pp. 172-183
ISSN:
0031-9422
Subject:
Polygonatum sibiricum; Western blotting; antineoplastic activity; antineoplastic agents; computer simulation; cytotoxicity; glycosides; human cell lines; hydrogen bonding; inhibitory concentration 50; mass spectrometry; neoplasm cells; nuclear magnetic resonance spectroscopy; rhizomes; screening; spectral analysis
Abstract:
... Screening assays showed that total glycoside-rich fraction (TG) of rhizomes of Polygonatum sibiricum unveiled remarkable anti-proliferative activities against three cancer cell lines (A549, HepG2, and Caco2). Activity-guided isolation of TG afforded seven undescribed steroidal glycosides (polygonosides 1–7), along with 24 known glycosides. Their structures were established by 1D and 2D NMR spectro ...
DOI:
10.1016/j.phytochem.2019.05.013

43. Antitumor Effect of Lonidamine-Polypeptide-Peptide Nanoparticles in Breast Cancer Models

Author:
Ifat Cohen-Erez; Carol Issacson; Yael Lavi; Ruthy Shaco-Levy; Jammi Milam; Brenda Laster; Levi A. Gheber; Hanna Rapaport
Source:
ACS applied materials & interfaces 2019 v.11 no.36 pp. 32670-32678
ISSN:
1944-8252
Subject:
adverse effects; animal models; antineoplastic activity; antineoplastic agents; biocompatible materials; breast neoplasms; cancer therapy; cell culture; clinical trials; cytotoxicity; drug delivery systems; freeze drying; glutamic acid; glycolysis; hepatotoxicity; intravenous injection; mitochondria; nanoparticles; neoplasm cells; pharmacokinetics; polyglutamic acid; polypeptides; solubility
Abstract:
... Biomaterials folded into nanoparticles (NPs) can be utilized as targeted drug delivery systems for cancer therapy. NPs may provide a vehicle for the anticancer drug lonidamine (LND), which inhibits glycolysis but was suspended from use at the clinical trial stage because of its hepatotoxicity due to poor solubility and pharmacokinetic properties. The NPs prepared by coassembly of the anionic polyp ...
DOI:
10.1021/acsami.9b09886

44. Antitumor Potential of Marine and Freshwater Lectins

Author:
Elena Catanzaro; Cinzia Calcabrini; Anupam Bishayee; Carmela Fimognari
Source:
Marine drugs 2019 v.18 no.1 pp. -
ISSN:
1660-3397
Subject:
algae; antineoplastic activity; antineoplastic agents; biodiversity; cell death; cell proliferation; clinical trials; freshwater; glycoproteins; lectins; marine environment; neoplasm cells; neoplasms; sugars; toxicity; toxicology; vertebrates
Abstract:
... Often, even the most effective antineoplastic drugs currently used in clinic do not efficiently allow complete healing due to the related toxicity. The reason for the toxicity lies in the lack of selectivity for cancer cells of the vast majority of anticancer agents. Thus, the need for new potent anticancer compounds characterized by a better toxicological profile is compelling. Lectins belong to ...
DOI:
10.3390/md18010011

45. Antitumor agent yatein from Calocedrus formosana Florin leaf induces apoptosis in non-small-cell lung cancer cells

Author:
Shang-Tse Ho; Chi-Chen Lin; Tung-Lin Wu; Yu-Tang Tung; Jyh-Horng Wu
Source:
Journal of wood science 2019 v.65 no.1 pp. 59
ISSN:
1435-0211
Subject:
Calocedrus formosana; NAD ADP-ribosyltransferase; antineoplastic agents; apoptosis; caspase-3; caspase-8; caspase-9; cell lines; cytotoxicity; flow cytometry; hexane; leaf extracts; lung neoplasms; neoplasm cells; regulatory proteins; Taiwan
Abstract:
... Calocedrus formosana Florin is a softwood tree species with high economic value in Taiwan. Several bioactivities of the extracts of C. formosana have been reported; however, only one study focused on the anti-non-small-cell lung cancer cells’ (anti-NSCLC) effect of C. formosana extract and its active phytocompound. In the present study, the anti-lung cancer effects of C. formosana leaf extract and ...
DOI:
10.1186/s10086-019-1838-9

46. Antrodia salmonea suppresses invasion and metastasis in triple-negative breast cancer cells by reversing EMT through the NF-κB and Wnt/β-catenin signaling pathway

Author:
You-Cheng Hseu; Yi-Chun Lin; Peramaiyan Rajendran; Varadharajan Thigarajan; Dony Chacko Mathew; Kai-Yuan Lin; Tzong-Der Way; Jiunn-Wang Liao; Hsin-Ling Yang
Source:
Food and chemical toxicology 2019 v.124 pp. 219-230
ISSN:
0278-6915
Subject:
Antrodia; Western blotting; antineoplastic activity; antineoplastic agents; beta catenin; bioluminescence; breast neoplasms; cadherins; enzyme activity; fluorescent antibody technique; fungi; image analysis; immunohistochemistry; luciferase; lungs; metastasis; mice; neoplasm cells; reverse transcriptase polymerase chain reaction; signal transduction; staining; tau-protein kinase; toxicology; transcription factor NF-kappa B; vascular endothelial growth factors; vimentin; Taiwan
Abstract:
... Antrodia salonea (AS), a fungus that is indigenous to Taiwan has been well known for its anti-cancer properties. We investigated the anti-metastatic and anti-epithelial-mesenchymal transition (EMT) properties of AS in TNBC cells. To determine their EMT and metastasis levels, in vitro wound healing, wound invasion, Western blotting, RT-PCR, luciferase activity and immunofluorescence assays were per ...
DOI:
10.1016/j.fct.2018.12.009

47. Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells

Author:
José C. Quilles Junior; Fernanda dos Reis Rocho Carlos; A. Montanari; Andrei Leitão; Viviane W. Mignone; Maria Augusta Arruda; Lyudmila Turyanska; Tracey D. Bradshaw
Source:
RSC advances 2019 v.9 no.63 pp. 36699-36706
ISSN:
2046-2069
Subject:
antineoplastic activity; antineoplastic agents; carcinogenesis; cathepsin L; cell cycle checkpoints; cysteine proteinase inhibitors; encapsulation; enzyme inhibition; ferritin; fibroblasts; humans; in vivo studies; neoplasm cells; neoplasms; protein degradation; transferrin receptors
Abstract:
... Cysteine proteases play a key role in tumorigenesis causing protein degradation and promoting invasive tumour growth. Cathepsin L is overexpressed in cancer cells and could provide a specific target for delivery of anticancer agents. We encapsulated novel dipeptidyl nitrile based cysteine protease inhibitors (Neq0551, Neq0554 and Neq0568) into biocompatible apoferritin (AFt) protein nanocages to a ...
DOI:
10.1039/c9ra07161j

48. Apoptosis and G2/M cell cycle arrest induced by a timosaponin A3 from Anemarrhena asphodeloides Bunge on AsPC-1 pancreatic cancer cells

Author:
Yumi Kim; Kang-Hoon Kim; In-Seung Lee; Ji Young Park; Yun-Cheol Na; Won-Seok Chung; Hyeung-Jin Jang
Source:
Phytomedicine 2019 v.56 pp. 48-56
ISSN:
0944-7113
Subject:
Anemarrhena asphodeloides; active ingredients; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cell growth; cell lines; cell proliferation; chemical constituents of plants; cyclins; cytotoxicity; drug therapy; ethyl acetate; genes; humans; immunoblotting; liquid chromatography; mass spectrometry; mechanism of action; metastasis; mitogen-activated protein kinase; neoplasm cells; pancreatic neoplasms; protein content; reverse transcription; saponins; solvents; viability
Abstract:
... Timosaponin A3 (TA3), one of the active components of spirostanol saponin isolated from A. asphodeloides, is widely used as an anticancer agent in a variety of cancer cell lines. However, the research on the anticancer efficacy is very limited in human pancreatic cancer models.In this study, we investigated the molecular targets in the active components of A. asphodeloides, which showed anti-cance ...
DOI:
10.1016/j.phymed.2018.08.006

49. Apoptosis effect of Aegiceras corniculatum on human colorectal cancer via activation of FoxO signaling pathway

Author:
Hua Luo; Erwei Hao; Dechao Tan; Wei Wei; Jinling Xie; Xiaohui Feng; Zhengcai Du; Chunying Huang; Gang Bai; Yuanyuan Hou; Chuanjing Cheng; Xiangxi Yi; Yitao Wang; Xiaotao Hou; Jiagang Deng
Source:
Food and chemical toxicology 2019 pp. -
ISSN:
0278-6915
Subject:
Aegiceras corniculatum; Western blotting; antineoplastic activity; antineoplastic agents; apoptosis; butanol; cell cycle checkpoints; cell lines; cell proliferation; colorectal neoplasms; dose response; flow cytometry; human diseases; leaf extracts; leaves; mechanism of action; mice; mitochondria; neoplasm cells; patients; proteins; signal transduction; viability
Abstract:
... Aegiceras corniculatum (L.) Blanco is known to exhibit anticancer effects against different types of cancer; however, to the best of our knowledge, the anticancer activity and underlying mechanisms of action of A. corniculatum leaf extract on colorectal cancer have not been elucidated. In the present study, colony-forming assay, western blot analysis, flow cytometry, and a xenograft model were use ...
DOI:
10.1016/j.fct.2019.110861

50. Application of temporary agglomeration of chitosan-coated nanoparticles for the treatment of lung metastasis of melanoma

Author:
Song Yi Lee; Ja Seong Koo; Mingyu Yang; Hyun-Jong Cho
Source:
Journal of colloid and interface science 2019 pp. -
ISSN:
0021-9797
Subject:
X-ray photoelectron spectroscopy; animal models; antineoplastic agents; blood flow; chitosan; dissociation; encapsulation; hydrodynamics; lungs; melanoma; metastasis; mixing; nanoparticles; serum albumin; zeta potential
Abstract:
... Temporary association of chitosan (CS)-coated nanoparticles (NPs) including phloretin (Phl) in the blood stream can be applied to treat lung metastasis of melanoma. Phl was entrapped in poly(D,L-lactide-co-glycolide) (PLGA) NPs as an anticancer agent, whereas CS was decorated onto the outer surfaces of the Phl-loaded PLGA NPs (PLGA/Phl NPs). CS-coated PLGA/Phl NPs (CS–PLGA/Phl NPs) with hydrodynam ...
DOI:
10.1016/j.jcis.2019.02.092