Publication Year: 2019 / Subject term: antioxidant activity and antineoplastic activity

1. A review on applications of chitosan-based Schiff bases

Author:: R. Antony; T. Arun; S. Theodore David Manickam
Source:: International journal of biological macromolecules 2019 v.129 pp. 615-633
ISSN:: 0141-8130
Subject:: adsorption; antimicrobial properties; antineoplastic activity; antioxidant activity; biopolymers; carbonyl compounds; catalytic activity; chitosan; condensation reactions; drug carriers; imines; schiff bases; tissue engineering; water treatment
Abstract:: ... Biopolymers have become very attractive as they are degradable, biocompatible, non-toxic and renewable. Due to the intrinsic reactive amino groups, chitosan is vibrant in the midst of other biopolymers. Using the versatility of these amino groups, various structural modifications have been accomplished on chitosan through certain chemical reactions. Chemical modification of chitosan via imine func ...
DOI:: 10.1016/j.ijbiomac.2019.02.047
: https://doi.org/10.1016/j.ijbiomac.2019.02.047

2. A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications

Author:: Heerasing Takooree; Muhammad Z. Aumeeruddy; Kannan R.R. Rengasamy; Katharigatta N. Venugopala; Rajesh Jeewon; Gokhan Zengin; Mohamad F. Mahomoodally
Source:: Critical reviews in food science and nutrition 2019 v.59 no.sup1 pp. S210
ISSN:: 1549-7852
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Piper nigrum; analgesics; anticonvulsants; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidant enzymes; apoptosis; autophagy; bacterial motility; bioactive compounds; biofilm; black pepper; breasts; cell lines; chemical constituents of plants; cholesterol; clinical trials; colon; cytotoxicity; databases; dietary supplements; digestive system diseases; flavor; fruits; high density lipoprotein; hydrogen peroxide; in vivo studies; ingredients; livestock; low density lipoprotein; molybdenum; neuroprotective effect; nitric oxide; nitrogen; oxygen; pathogens; pharmacokinetics; seeds; signal transduction; superoxide anion; systematic review; taste; transporters; triacylglycerols; veterinary medicine; India
Abstract:: ... Considered as the “King of spices”, black pepper (Piper nigrum L.) is a widely used spice which adds flavor of its own to dishes, and also enhances the taste of other ingredients. Piper nigrum has also been extensively explored for its biological properties and its bioactive phyto-compounds. There is, however, no updated compilation of these available data to provide a complete profile of the medi ...
DOI:: 10.1080/10408398.2019.1565489
: https://doi.org/10.1080/10408398.2019.1565489

3. Allium vegetables for possible future of cancer treatment

Author:: Yahya Asemani; Nasrindokht Zamani; Maryam Bayat; Zahra Amirghofran
Source:: Phytotherapy research 2019 v.33 no.12 pp. 3019-3039
ISSN:: 0951-418X
Subject:: Allium; adverse effects; ajoene; antineoplastic activity; antineoplastic agents; antioxidant activity; apoptosis; cell cycle; chives; garlic; health effects assessments; ingredients; leeks; medicinal plants; metastasis; neoplasm cells; neoplasms; quercetin; shallots; signal transduction; sulfur; therapeutics; traditional medicine
Abstract:: ... Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, onions, leeks, chives, and shallots. These plants have been exploited in folk medicine because of their beneficial health effects in improving numerou ...
DOI:: 10.1002/ptr.6490
: https://doi.org/10.1002/ptr.6490

4. An update on the mechanisms related to cell death and toxicity of doxorubicin and the protective role of nutrients

Author:: Alfonso Varela-López; Maurizio Battino; María D. Navarro-Hortal; Francesca Giampieri; Tamara Y. Forbes-Hernández; José M. Romero-Márquez; Ricardo Collado; José L. Quiles
Source:: Food and chemical toxicology 2019 pp. -
ISSN:: 0278-6915
Subject:: antineoplastic activity; antioxidant activity; ascorbic acids; autophagy; bioactive compounds; bone marrow; brain; calcium; cardiotoxicity; cell lines; clinical trials; dietary minerals; doxorubicin; drug therapy; homeostasis; kidneys; liver; mechanism of action; neoplasm cells; neoplasms; nutrients; omega-3 fatty acids; protective effect; selenium; testes; toxicity; vitamin A; vitamin E
Abstract:: ... Doxorubicin (DOX), is a very effective chemotherapeutic agent against cancer whose clinical use is limited by toxicity. Different strategies have been proposed to attenuate toxicity, including combined therapy with bioactive compounds. This review update mechanisms of action and toxicity of doxorubicin and the role of nutrients like vitamins (A, C, E), minerals (selenium) and n-3 polyunsaturated f ...
DOI:: 10.1016/j.fct.2019.110834
: https://doi.org/10.1016/j.fct.2019.110834

5. Anchusa azurea Mill. (Boraginaceae) aerial parts methanol extract interfering with cytoskeleton organization induces programmed cancer cells death

Author:: Jessica CeramellaThese authors have contributed equally to the manuscript.; Monica Rosa Loizzo; Domenico Iacopetta; Marco Bonesi; Vincenzo Sicari; Teresa Maria Pellicanò; Carmela Saturnino; Aurélie Malzert-Fréon; Rosa TundisJoint senior authors.; Maria Stefania Sinicropi
Source:: Food & function 2019 v.10 no.7 pp. 4280-4290
ISSN:: 2042-650X
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Anchusa azurea; aerial parts; antineoplastic activity; antioxidant activity; beta-carotene; bleaching; caffeic acid; caspase-3; catechin; cell death; cell lines; chemical composition; chlorogenic acid; cytoskeleton; death; high performance liquid chromatography; inhibitory concentration 50; menadione; methanol; mice; neoplasm cells; neoplasms; oxidative stress; toxicity
Abstract:: ... The present study aimed to determine the chemical composition, antioxidant effects and antitumor properties of a methanol extract of Anchusa azurea Mill. (Boraginaceae) aerial parts against four tumour cell lines (MCF-7, MDA-MB-231, RKO, and R₂C). The antioxidant effects were assessed by using β-carotene bleaching, 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picryl ...
DOI:: 10.1039/c9fo00582j
: https://doi.org/10.1039/c9fo00582j

6. Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin

Author:: Luan He; Yong Zhang; Naixin Kang; Yaner Wang; Ziyu Zhang; Zhengxia Zha; Shilin Yang; Qiongming Xu; Yanli Liu
Source:: Phytomedicine 2019 v.56 pp. 136-146
ISSN:: 0944-7113
Subject:: Anemone chinensis; Western blotting; adverse effects; anti-inflammatory activity; antineoplastic activity; antioxidant activity; apoptosis; blood; body weight; catalase; cell viability; cisplatin; creatinine; drug therapy; flow cytometry; glutathione; histopathology; in vivo studies; kidneys; mice; models; neoplasms; nephrotoxicity; protective effect; reactive oxygen species; renal failure; saponins; superoxide dismutase; urea nitrogen
Abstract:: ... Cisplatin is a highly effective chemotherapeutic agent commonly used in the treatment of a wide variety of malignancies. However, its clinical usage is severely limited by its serious side effects, especially nephrotoxicity. Anemoside B4, is a major saponins, rich in root of Pulsatilla chinensis (Bunge), has anti-inflammation in vitro. However, the antioxidant or anti-inflammatory effects of anemo ...
DOI:: 10.1016/j.phymed.2018.10.035
: https://doi.org/10.1016/j.phymed.2018.10.035

7. Anti-Aging Effect of Agar Oligosaccharide on Male Drosophila melanogaster and Its Preliminary Mechanism

Author:: Chao Ma; Kun Yang; Yifan Wang; Xianjun Dai
Source:: Marine drugs 2019 v.17 no.11 pp. -
ISSN:: 1660-3397
Subject:: Drosophila melanogaster; agar; anti-aging properties; antineoplastic activity; antioxidant activity; catalase; gene expression regulation; genes; immunity; immunomodulators; insect reproduction; intestinal microorganisms; intestines; longevity; male fertility; males; malondialdehyde; microbial communities; midgut; oligosaccharides; prebiotics; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; ribosomal DNA; sequence analysis; vigor
Abstract:: ... Agar oligosaccharide (AOS) is a marine prebiotic with apparent anti-inflammatory, antioxidant and anti-tumor effects. During this study, different doses of AOS are added to a basal diet to evaluate its effects on the lifespan, motor vigor and reproduction of male Drosophila melanogaster. Additionally, the activities of Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and catalase (CAT) and the malondialdehy ...
DOI:: 10.3390/md17110632
PubMed:: 31698828
PubMed Central:: PMC6891751
: https://doi.org/10.3390/md17110632

8. Anti-inflammatory effect of Vaccinium oldhamii stems through inhibition of NF-κB and MAPK/ATF2 signaling activation in LPS-stimulated RAW264.7 cells

Author:: Ha Na Kim; Jueng Kyu Baek; Su Bin Park; Jeong Dong Kim; Ho-Jun Son; Gwang Hun Park; Hyun Ji Eo; Jae Ho Park; Hyuk-Sang Jung; Jin Boo Jeong
Source:: BMC complementary and alternative medicine 2019 v.19 no.1 pp. 291
ISSN:: 1472-6882
Subject:: Vaccinium; Western blotting; acetylcholinesterase; alpha-amylase; alternative medicine; anti-inflammatory activity; antineoplastic activity; antioxidant activity; cathepsin K; cell viability; chemoprevention; enzyme activity; enzyme-linked immunosorbent assay; genes; inducible nitric oxide synthase; interleukin-1beta; interleukin-6; messenger RNA; mitogen-activated protein kinase; nitric oxide; phosphorylation; prostaglandins; protein content; reverse transcriptase polymerase chain reaction; stem extracts; stems; toxicity testing; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... BACKGROUND: Vaccinium oldhamii (V. oldhamii) has been reported to exert a variety of the pharmacological properties such as anti-oxidant activity, anti-cancer activity, and inhibitory activity of α-amylase and acetylcholinesterase. However, the anti-inflammatory activity of V. oldhamii has not been studied. In this study, we aimed to investigate anti-inflammatory activity of the stem extracts from ...
DOI:: 10.1186/s12906-019-2720-4
PubMed:: 31684931
PubMed Central:: PMC6827179
: https://doi.org/10.1186/s12906-019-2720-4

9. Anti-proliferative, pro-apoptotic and anti-oxidative activity of Lactobacillus and Bifidobacterium strains: A review of mechanisms and therapeutic perspectives

Author:: Adriana Nowak; Anna Paliwoda; Janusz Błasiak
Source:: Critical reviews in food science and nutrition 2019 v.59 no.21 pp. 3456-3467
ISSN:: 1549-7852
Subject:: Bifidobacterium; Lactobacillus; antineoplastic activity; antioxidant activity; antioxidant enzymes; apoptosis; bacteria; carcinogens; cell cycle; cell proliferation; molecular weight; neoplasm cells; neoplasms; proteins; reactive oxygen species; therapeutics; transition elements
Abstract:: ... Lactobacillus and Bifidobacterium strains, their isolated constituents and substances that they secrete exert various anti-cancer actions, resulting from their anti-proliferative, pro-apoptotic and anti-oxidant properties. They can express and secrete anti-oxidant enzymes, bind reactive oxygen species, release small molecular weight anti-oxidants and chelate transition metals, preventing detriment ...
DOI:: 10.1080/10408398.2018.1494539
: https://doi.org/10.1080/10408398.2018.1494539

10. Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk

Author:: Muhammad Shahid Riaz Rajoka; Haobin Zhao; Hafiza Mahreen Mehwish; Na Li; Yao Lu; Ziyang Lian; Dongyan Shao; Mingliang Jin; Qi Li; Liqing Zhao; Junling Shi
Source:: Food research international 2019 v.123 pp. 286-297
ISSN:: 0963-9969
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Lactobacillus rhamnosus; Western blotting; antineoplastic activity; antioxidant activity; apoptosis; breast milk; cell free system; cytotoxicity; free radicals; gene expression regulation; genes; human cell lines; human health; hydroxyl radicals; immune system; liquids; neoplasm cells; nutrients; pathogens; probiotics; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; superoxide anion; uterine cervical neoplasms
Abstract:: ... Lactobacilli rhamnosus has been characterized as a probiotic and plays an important role in human health by stimulating the supplement of nutrients, preventing the colonization of pathogens, and influencing the immune system. This study investigated the anticancer activity of the three Lactobacillus rhamnosus strains SHA111, SHA112, and SHA113 isolated from human breast milk. The cell-free superna ...
DOI:: 10.1016/j.foodres.2019.05.002
: https://doi.org/10.1016/j.foodres.2019.05.002

11. Anticancer, antimicrobial, antioxidant, and catalytic activities of green-synthesized silver and gold nanoparticles using Bauhinia purpurea leaf extract

Author:: Remya Vijayan; Siby Joseph; Beena Mathew
Source:: Bioprocess and biosystems engineering 2019 v.42 no.2 pp. 305-319
ISSN:: 1615-7591
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Bauhinia purpurea; Fourier transform infrared spectroscopy; X-ray diffraction; agar; antineoplastic activity; antioxidant activity; antioxidants; catalysts; catalytic activity; cell lines; dose response; dyes; energy-dispersive X-ray analysis; gold; inhibitory concentration 50; leaf extracts; lung neoplasms; medicinal plants; nanogold; nanoparticles; nanosilver; neoplasm cells; silver; stabilizers; surface plasmon resonance; transmission electron microscopy
Abstract:: ... The synthesis of metal nanoparticles by green methods attained enormous attention in recent years due to its easiness, non-toxicity, and eco-friendly nature. In the present study, noble metal nanoparticles such as silver and gold were prepared using an aqueous leaf extract of a medicinal plant, Bauhinia purpurea. The leaf extract performed as both reducing and stabilizing agents for the developmen ...
DOI:: 10.1007/s00449-018-2035-8
: https://doi.org/10.1007/s00449-018-2035-8

12. Antihepatocarcinogenic activity of whey protein concentrate and lactoferrin in diethylnitrosamine‐treated male albino mice

Author:: Marwa M. Mohammed; Gamal Ramadan; Mona K. Zoheiry; Nadia M. El‐Beih
Source:: Environmental toxicology 2019 v.34 no.9 pp. 1025-1033
ISSN:: 1520-4081
Subject:: DNA fragmentation; animal models; antineoplastic activity; antioxidant activity; apoptosis; blood serum; body weight; carcinoma; caspases; catalase; cattle; cytotoxicity; diethylnitrosamine; dose response; drug therapy; glutathione; glutathione peroxidase; hepatoma; histology; inflammation; lactoferrin; liver; males; mice; superoxide dismutase; whey protein concentrate
Abstract:: ... Hepatocellular carcinoma is considered one of the most prevalent and lethal malignancies worldwide. Chemotherapy with cytotoxic agents showed a low response rate with possible toxic effects. Recently, some emphases have been placed on the anticancer properties of bovine whey protein and its components, especially lactoferrin. The present study aimed to evaluate and compare the antihepatocarcinogen ...
DOI:: 10.1002/tox.22773
: https://doi.org/10.1002/tox.22773

13. Antioxidant Capacity and Cytotoxic Effects of Catechins and Resveratrol Oligomers Produced by Enzymatic Oxidation against T24 Human Urinary Bladder Cancer Cells

Author:: Claudia Lizet Meneses-Gutiérrez; Jacqueline Hernández-Damián; José Pedraza-Chaverri; Isabel Guerrero-Legarreta; Dario Iker Téllez; María Eugenia Jaramillo-Flores
Source:: Antioxidants 2019 v.8 no.7 pp. -
ISSN:: 2076-3921
Subject:: antineoplastic activity; antioxidant activity; catechin; cisplatin; copper; cytotoxicity; epicatechin; human cell lines; humans; iron; metal ions; neoplasm cells; oxidation; peroxidase; polymerization; reactive oxygen species; resveratrol; therapeutics; urinary bladder neoplasms
Abstract:: ... In this work the polymerization of catechin, epicatechin, and resveratrol was carried out through a peroxidase oxidation process in order to improve the biological activity of these phenolic compounds. The antioxidant activity of the oligomers was evaluated by their ability to scavenge reactive oxygen species (ROS) and their capacity to chelate metal ions Fe2+ and Cu2+. The antitumor effect of the ...
DOI:: 10.3390/antiox8070214
PubMed:: 31295839
PubMed Central:: PMC6680426
: https://doi.org/10.3390/antiox8070214

14. Antioxidant activities of α-lipoic acid free and nano-capsule inhibit the growth of Ehrlich carcinoma

Author:: Monira M. Rageh; Reem H. El-Gebaly
Source:: Molecular biology reports 2019 v.46 no.3 pp. 3141-3148
ISSN:: 0301-4851
Subject:: DNA damage; antineoplastic activity; antioxidant activity; carcinoma; comet assay; enzyme activity; histopathology; lipoic acid; malondialdehyde; mice; oxidative stress; superoxide dismutase; tissues; transmission electron microscopy
Abstract:: ... To evaluate the relationship between oxidative stress, DNA damage, and suppression of tumor growth induced by lipoic acid free and nano-capsule. Lipoic acid nano-capsule was assessed by transmission electron microscopy (TEM). The antitumor activity of lipoic acid free and nano-capsule was investigated in Ehrlich solid tumor bearing mice. The endpoints measured were superoxide dismutase (SOD) enzym ...
DOI:: 10.1007/s11033-019-04769-9
: https://doi.org/10.1007/s11033-019-04769-9

15. Antioxidant and anticancer effects in human hepatocarcinoma (HepG2) cells of papain-hydrolyzed sorghum kafirin hydrolysates

Author:: Shiwei Xu; Yanting Shen; Jingwen Xu; Guangyan Qi; Gengjun Chen; Weiqun Wang; Xiuzhi Sun; Yonghui Li
Source:: Journal of functional foods 2019 v.58 pp. 374-382
ISSN:: 1756-4646
Subject:: antineoplastic activity; antioxidant activity; antioxidants; cell growth; emulsions; food industry; fractionation; ground meat; hepatoma; human cell lines; hydrolysates; hydrolysis; kafirins; lipid peroxidation; oxidation; peptides; reversed-phase high performance liquid chromatography; turbidity; ultrafiltration
Abstract:: ... Peptide antioxidants are becoming increasingly popular in the food industry. This study reported antioxidant and anticancer properties of papain-hydrolyzed sorghum kafirin. The optimum hydrolysis conditions were determined to be 360 kU/g enzyme-to-substrate ratio, and 4 h of reaction time. After ultrafiltration, the 1–3 kDa hydrolysate fraction demonstrating promising antioxidative activities as w ...
DOI:: 10.1016/j.jff.2019.05.016
: https://doi.org/10.1016/j.jff.2019.05.016

16. Antioxidant and immunomodulatory activity induced by stevioside in liver damage: In vivo, in vitro and in silico assays

Author:: Sael Casas-Grajales; Erika Ramos-Tovar; Esmeralda Chávez-Estrada; Diana Alvarez-Suarez; Erika Hernández-Aquino; Karina Reyes-Gordillo; Carlos M. Cerda-García-Rojas; Javier Camacho; Víctor Tsutsumi; M. Raj Lakshman; Pablo Muriel
Source:: Life sciences 2019 v.224 pp. 187-196
ISSN:: 0024-3205
Subject:: Stevia rebaudiana; Toll-like receptors; antineoplastic activity; antioxidant activity; antioxidants; coculture; cytokines; ethanol; gene expression regulation; genes; immune response; immunomodulators; inflammation; laboratory animals; leaves; lipopolysaccharides; liver; males; protein synthesis; rats; stevioside; transcription factor NF-kappa B; tumor necrosis factor receptors
Abstract:: ... Stevioside is a diterpenoid obtained from the leaves of Stevia rebaudiana (Bertoni) that exhibits antioxidant, antifibrotic, antiglycemic and anticancer properties. Therefore, we aimed to study whether stevioside has beneficial effects in liver injury induced by long-term thioacetamide (TAA) administration and investigated the possible underlying molecular mechanism using in vivo, in vitro and in ...
DOI:: 10.1016/j.lfs.2019.03.035
PubMed:: 30890404
PubMed Central:: PMC6556435
: https://doi.org/10.1016/j.lfs.2019.03.035

17. Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes

Author:: Peng Liu; Wei Wang; Jonathan Tang; Richard P. Bowater; Yongping Bao
Source:: Food and chemical toxicology 2019 v.128 pp. 129-136
ISSN:: 0278-6915
Subject:: DNA damage; antineoplastic activity; antioxidant activity; cell death; cell viability; clinical trials; enzymes; glutathione; hepatocytes; hepatoma; human cell lines; humans; hydrogen peroxide; neoplasm cells; protective effect; risk; sulforaphane; toxicity; toxicology
Abstract:: ... Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocytes (HHL5) and hepatoma (HepG2) cells. Results showed that SFN inhibited cell viability and induced DNA strand breaks at high doses (≥20 μM). It also activated the nuclear factor (erythroid-derived 2)-l ...
DOI:: 10.1016/j.fct.2019.03.050
: https://doi.org/10.1016/j.fct.2019.03.050

18. Antioxidant, cytotoxicity and anti-tumor activity of Cordia dichotoma fruits accompanied with its volatile and sugar composition

Author:: Abeer Y. Ibrahim; Samah A. El-Newary; Gamil E. Ibrahim
Source:: Annals of agricultural science 2019 v.64 no.1 pp. 29-37
ISSN:: 0570-1783
Subject:: Cordia dichotoma; alkaloids; alpha-phellandrene; alpha-terpineol; antineoplastic activity; antineoplastic agents; antioxidant activity; ascites; body weight; bornyl acetate; butyrates; carcinoma; catechin; chemical composition; cytotoxicity; dose response; fructose; fruit pulp; fruits; gallic acid; gas chromatography-mass spectrometry; glucose; hematologic tests; high performance liquid chromatography; ions; lethal dose 50; longevity; metals; mice; phenols; quercetin; sucrose; superoxide anion; tannins; volatile compounds
Abstract:: ... The aim of the present research was to investigate the chemical composition, antioxidant and anti-tumor effects of Cordia dichotoma fruit pulp extract “CDFP-extract”. Day after intraperitoneal inoculation of Ehrlich ascites carcinoma (EAC) cells in mice, CDFP-extract was administered orally at 500 mg/kg body weight (equal to 0.10 of determined LD50) for ten consecutive days. CDFP-extract contains ...
DOI:: 10.1016/j.aoas.2019.05.008
: https://doi.org/10.1016/j.aoas.2019.05.008

19. Antioxidative, Anti-Inflammatory, and Anticancer Effects of Purified Flavonol Glycosides and Aglycones in Green Tea

Author:: Chan-Su Rha; Hyun Woo Jeong; Saitbyul Park; Siyoung Lee; Young Sung Jung; Dae-Ok Kim
Source:: Antioxidants 2019 v.8 no.8 pp. -
ISSN:: 2076-3921
Subject:: adenoma; antineoplastic activity; antioxidant activity; apigenin; breast neoplasms; cell lines; colon; dose response; endo-1,4-beta-glucanase; flavanols; gene expression; genes; glycosides; green tea; kaempferol; macrophages; mass spectrometry; messenger RNA; mice; models; myricetin; neoplasm cells; oxidative stress; paclitaxel; quercetin; tannase; viability
Abstract:: ... (1) Background: Extensive research has focused on flavan-3-ols, but information about the bioactivities of green tea flavonols is limited. (2) Methods: In this study, we investigated the antioxidative, anti-inflammatory, and anticancer effects of flavonol glycosides and aglycones from green tea using in vitro cell models. The fractions rich in flavonol glycoside (FLG) and flavonol aglycone (FLA) w ...
DOI:: 10.3390/antiox8080278
PubMed:: 31387266
PubMed Central:: PMC6719943
: https://doi.org/10.3390/antiox8080278

20. Antitumor activity of Cuphea ignea extract against benzo(a)pyrene-induced lung tumorigenesis in Swiss Albino mice

Author:: Sherien K. Hassan; Amria M. Mousa; Nermin M. El-Sammad; Abeer H. Abdel-Halim; Wagdy K.B. Khalil; Elsayed A. Elsayed; Nayera Anwar; Michael W. Linscheid; Eman S. Moustafa; Amani N. Hashim; Mahmoud Nawwar
Source:: Toxicology reports 2019 v.6 pp. 1071-1085
ISSN:: 2214-7500
Subject:: Cuphea ignea; albino; antineoplastic activity; antioxidant activity; blood serum; body weight; carcinogenesis; caspase-3; chemoprevention; cytotoxicity; histopathology; humans; lipid peroxidation; lung neoplasms; lungs; metalloproteinases; mice; mortality; neoplasm cells; oral administration; toxicology
Abstract:: ... Lung cancer has one of the highest mortality rates among various types of cancer and is the most frequent cancer in the world. The incidence of lung cancer is increasing rapidly, in parallel with an increased incidence of smoking. Effective chemoprevention may be an alternative strategy to control the incidence of lung cancer. Thus, the objective of current work was to ascertain the possible preve ...
DOI:: 10.1016/j.toxrep.2019.10.004
: https://doi.org/10.1016/j.toxrep.2019.10.004

21. Antitumor and antioxidant effects of Clinacanthus nutans Lindau in 4 T1 tumor-bearing mice

Author:: Nik Mohd Afizan Nik Abd Rahman; M. Y. Nurliyana; M. N. F. Natasha Nur Afiqah; Mohd Azuraidi Osman; Muhajir Hamid; Mohd Azmi Mohd Lila
Source:: BMC complementary and alternative medicine 2019 v.19 no.1 pp. 340
ISSN:: 1472-6882
Subject:: Clinacanthus nutans; adverse effects; alternative medicine; animal disease models; antineoplastic activity; antioxidant activity; apoptosis; blood serum; bone marrow; breast neoplasms; chemical constituents of plants; cytokines; enzyme-linked immunosorbent assay; eosin; grasses; inflammation; liver; lungs; malondialdehyde; methanol; mitosis; nitric oxide; plant extracts; snakes; splenocytes; Borneo; Malaysia
Abstract:: ... BACKGROUND: Clinacanthus nutans Lindau (C. nutans) is a species of in Acanthaceae family and primarily used in South East Asian countries. C. nutans is well known as Sabah snake grass in Malaysia, and its leaves have diverse medicinal potential in conventional applications, including cancer treatments. On the basis of literature search, there is less conclusive evidence of the involvement of phyto ...
DOI:: 10.1186/s12906-019-2757-4
PubMed:: 31783838
PubMed Central:: PMC6884788
: https://doi.org/10.1186/s12906-019-2757-4

22. Assessing Anticancer Potential of Blueberry Flavonoids, Quercetin, Kaempferol, and Gentisic Acid, Through Oxidative Stress and Apoptosis Parameters on HCT-116 Cells

Author:: Ebru Demirel Sezer; Latife Merve Oktay; Elif Karadadaş; Hikmet Memmedov; Nur Selvi Gunel; Eser Sözmen
Source:: Journal of medicinal food 2019 v.22 no.11 pp. 1118-1126
ISSN:: 1557-7600
Subject:: 2,5-dihydroxybenzoic acid; Vaccinium myrtillus; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; blueberries; cytotoxicity; diet; flow cytometry; fruit extracts; kaempferol; liquid chromatography; neoplasms; oxidants; oxidative stress; polyphenols; protein composition; protein microarrays; proteins; quercetin; tandem mass spectrometry; therapeutics
Abstract:: ... In recent years, natural products gained popularity with their anti-inflammatory and antioxidant effects mediated by chemical compounds within their composition. Study results offering them as palliative therapy options in cancer or as anticancer agents with high levels of cytotoxicity brought a new approach to combine cancer treatment protocols with these products. From a different perspective, e ...
DOI:: 10.1089/jmf.2019.0098
: https://doi.org/10.1089/jmf.2019.0098

23. Assessment of the cytotoxicity, antioxidant activity and chemical composition of extracts from the cyanobacterium Fischerella major Gomont

Author:: Tsvetelina Batsalova; Diyana Basheva; Krum Bardarov; Ventzislav Bardarov; Balik Dzhambazov; Ivanka Teneva
Source:: Chemosphere 2019 v.218 pp. 93-103
ISSN:: 0045-6535
Subject:: Fischerella; active ingredients; antibiotics; antifungal properties; antineoplastic activity; antioxidant activity; antioxidants; cell culture; cell lines; cytotoxicity; environmental assessment; environmental impact; exposure duration; hormones; human health; immunosuppressive agents; in vitro studies; insecticides; microcystins; photosynthesis; repellents; risk assessment; saxitoxins; vitamins
Abstract:: ... Cyanoprokaryotes (Cyanobacteria/Cyanophyta) are ancient photosynthetic prokaryotic organisms with cosmopolitan distribution. They are producers of a number of biologically active substances with antitumor and antifungal activity, vitamins, antibiotics, algaecides, insecticides, repellents, hormones, immunosuppressants and toxins. So far, the cyanobacterium Fischerella major Gomont has not been stu ...
DOI:: 10.1016/j.chemosphere.2018.11.097
: https://doi.org/10.1016/j.chemosphere.2018.11.097

24. Betulinic Acid, the first lupane-type triterpenoid isolated via bioactivity-guided fractionation, and identified by spectroscopic analysis from leaves of Nyctanthes arbor-tristis: its potential biological activities in vitro assays

Author:: Birendra Nath Karan; Tapan Kumar Maity; Bikash Chandra Pal; Tanushree Singha; Snehasis Jana
Source:: Natural product research 2019 v.33 no.22 pp. 3287-3292
ISSN:: 1478-6427
Subject:: Fourier transform infrared spectroscopy; Nyctanthes arbor-tristis; anti-inflammatory activity; antineoplastic activity; antioxidant activity; betulinic acid; carbon; cytotoxicity; ethyl acetate; fractionation; human cell lines; humans; in vitro studies; inhibitory concentration 50; leaves; mass spectrometry; neoplasm cells; neoplasms; nitrites; nuclear magnetic resonance spectroscopy; spectral analysis; stable isotopes; tumor necrosis factor-alpha
Abstract:: ... Betulinic acid was first time isolated via bioactivity-guided fractionation from ethyl acetate extract of Nyctanthes arbor-tristis leaves. Its structure was established by FTIR, ¹H and ¹³C- nuclear magnetic resonance and high-resolution mass spectrometry. It had shown excellent inhibition of anti-inflammatory properties with IC₅₀ of 10.34 μg/mL (COX-1), 12.92 μg/mL (COX-2), 15.53 μg/mL (5-LOX), 15 ...
DOI:: 10.1080/14786419.2018.1470171
: https://doi.org/10.1080/14786419.2018.1470171

25. Bioactive peptide with antioxidant and anticancer activities from black soybean [Glycine max (L.) Merr.] byproduct: isolation, identification and molecular docking study

Author:: Zhongqin Chen; Weiwei Li; Ramesh Kumar Santhanam; Cong Wang; Xudong Gao; Yue Chen; Chunli Wang; Leilei Xu; Haixia Chen
Source:: European food research & technology 2019 v.245 no.3 pp. 677-689
ISSN:: 1438-2377
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Glycine max; antineoplastic activity; antioxidant activity; apoptosis; byproducts; caspase-3; caspase-7; computer simulation; cytotoxicity; drugs; energy; food research; free radical scavengers; functional foods; human cell lines; hydrogen bonding; hydrolysates; hydrophobicity; hydroxyl radicals; inhibitory concentration 50; isolation techniques; liver; lungs; molecular weight; neoplasm cells; neoplasms; peptides; reversed-phase high performance liquid chromatography; soy protein; soybeans; ultrafiltration
Abstract:: ... In this study, a novel peptide was isolated from the black soybean byproduct using bioactive guided isolation technique. Initially, the hydrolysate of black soybean protein was fractionated and separated sequentially by ultrafiltration, Sephadex G 25 chromatography and reverse-phase HPLC techniques. The peptide fractions that collected in each step were tested for their antioxidant capacity and an ...
DOI:: 10.1007/s00217-018-3190-5
: https://doi.org/10.1007/s00217-018-3190-5

26. Capillary electrophoresis, high‐performance liquid chromatography, and thin‐layer chromatography analyses of phenolic compounds from rapeseed plants and evaluation of their antioxidant activity

Author:: Yang Huang; Olivia Jansen; Michel Frédérich; Ange Mouithys‐Mickalad; Gwenaël Nys; Anne‐Catherine Servais; Jacques Crommen; Zhengjin Jiang; Marianne Fillet
Source:: Journal of separation science 2019 v.42 no.2 pp. 609-618
ISSN:: 1615-9306
Subject:: 2,2-diphenyl-1-picrylhydrazyl; antineoplastic activity; antioxidant activity; capillary electrophoresis; electron paramagnetic resonance spectroscopy; flavonoids; flowers; free radicals; high performance liquid chromatography; leaves; oils; phenolic acids; polyphenols; rapeseed; seeds; thin layer chromatography
Abstract:: ... Rapeseed plants, known for oil production, are also known to contain phenolic compounds such as phenolic acids and flavonoids, with potential antioxidant and anticancer activities. The separation and identification of 11 phenolic acids in rapeseed extracts (including leaves, flowers, Chinese seeds, Belgian seeds, and cake) by capillary electrophoresis were investigated. The results were compared w ...
DOI:: 10.1002/jssc.201800712
: https://doi.org/10.1002/jssc.201800712

27. Changes Over the Fermentation Period in Phenolic Compounds and Antioxidant and Anticancer Activities of Blueberries Fermented by Lactobacillus plantarum

Author:: Ji‐Yeon Ryu; Hye Rim Kang; Somi Kim Cho
Source:: Journal of food science 2019 v.84 no.8 pp. 2347-2356
ISSN:: 0022-1147
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Lactobacillus plantarum; additives; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; blueberries; catechol; chlorogenic acid; epigallocatechin; ethanol; fermentation; free radicals; gallic acid; high performance liquid chromatography; human cell lines; lactic acid bacteria; malvidin; metabolites; phenol; polyphenols; protocatechuic acid; syringic acid; uterine cervical neoplasms
Abstract:: ... This study determined the effects of blueberry fermentation by Lactobacillus plantarum on antioxidant and anticancer activities. The fermented blueberries extracted with 80% ethanol (FBE) showed increased superoxide dismutase‐like activity, increased scavenging of DPPH and alkyl radicals, and increased antiproliferative activity against human cervical carcinoma HeLa cells by inducing apoptosis. Se ...
DOI:: 10.1111/1750-3841.14731
: https://doi.org/10.1111/1750-3841.14731

28. Characterization, antioxidant, and anticancer activities of a neutral polysaccharide from Duchesnea indica (Andr.) Focke

Author:: Bolin Xiang; Xiaodong Yu; Bo Li; Yan Xiong; Min Long; Qiyi He
Source:: Journal of food biochemistry 2019 v.43 no.7 pp. e12899
ISSN:: 0145-8884
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Duchesnea indica; Fourier transform infrared spectroscopy; Oriental traditional medicine; anion exchange; antineoplastic activity; antioxidant activity; antioxidants; arabinose; cellulose; dose response; ethanol; fever; food industry; free radicals; functional foods; galactose; gel chromatography; glucosamine; glucose; hemorrhage; human cell lines; immunomodulators; inflammation; inhibitory concentration 50; leprosy; mannose; molecular weight; neoplasms; pharmaceutical industry; scanning electron microscopes; therapeutics; ultraviolet-visible spectroscopy
Abstract:: ... A neutral polysaccharide (DIP‐1) from Duchesnea indica (Andr.) Focke was obtained by hot water extraction, ethanol precipitation and chromatographic separation (DEAE‐52 cellulose anion‐exchange column and Sephadex G‐100 gel column). The physicochemical properties of DIP‐1 were elucidated by gel permeation chromatography, monosaccharide composition, Fourier transform infrared spectrometry, UV–visib ...
DOI:: 10.1111/jfbc.12899
: https://doi.org/10.1111/jfbc.12899

29. Characterization, the Antioxidant and Antimicrobial Activity of Exopolysaccharide Isolated from Poultry Origin Lactobacilli

Author:: Muhammad Shahid Riaz Rajoka; Hafiza Mahreen Mehwish; Hafiz Fakhar Hayat; Nazim Hussain; Sobia Sarwar; Humaira Aslam; Ahmad Nadeem; Junling Shi
Source:: Probiotics and antimicrobial proteins 2019 v.11 no.4 pp. 1132-1142
ISSN:: 1867-1306
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Escherichia coli; Lactobacillus reuteri; Lactobacillus vaginalis; Salmonella Typhimurium; antibacterial properties; antineoplastic activity; antioxidant activity; biopolymers; cecum; colorectal neoplasms; emulsifying properties; exopolysaccharides; foods; free radicals; hens; hydroxyl radicals; medicine; scanning electron microscopy; superoxide anion
Abstract:: ... The natural antioxidant agent is urgently needed to prevent the negative effects of newly generated free radicals and chronic disorders. Recently, the microbial exopolysaccharide (EPS) is currently used as a potential biopolymer due to its unique biological characteristics. In this study, the biological potential was carried out on the EPSs produced by Lactobacillus reuteri SHA101 (EPS-lr) and Lac ...
DOI:: 10.1007/s12602-018-9494-8
: https://doi.org/10.1007/s12602-018-9494-8

30. Chemical composition and bioactivity of essential oils and Ethanolic extracts of Ocimum basilicum L. and Thymus algeriensis Boiss. & Reut. from the Algerian Saharan Atlas

Author:: Maria Rezzoug; Boulanouar Bakchiche; Abdelaziz Gherib; Ascrizzi Roberta; FlaminiGuido; Özge Kilinçarslan; Ramazan Mammadov; Sanaa K. Bardaweel
Source:: BMC complementary and alternative medicine 2019 v.19 no.1 pp. 146
ISSN:: 1472-6882
Subject:: Gram-negative bacteria; Gram-positive bacteria; Ocimum basilicum; Thymus algeriensis; acetates; aerial parts; alpha-pinene; alternative medicine; aluminum chloride; antimicrobial properties; antineoplastic activity; antioxidant activity; bioactive compounds; cell growth; chemical analysis; dietary supplements; essential oils; flavonoids; food industry; free radical scavengers; fungi; gas chromatography-mass spectrometry; high performance liquid chromatography; human cell lines; humans; hydrodistillation; lethal dose 50; linalool; minimum inhibitory concentration; neoplasm cells; neoplasms; oils; pathogens; phenols; toxicity testing
Abstract:: ... BACKGROUND: There is increasing interest in the pharmaceutical and food industries to substitute synthetic chemicals with naturally occurring compounds possessing bioactive properties. Plants are valuable sources of bioactive compounds. The present study investigates the chemical composition and antioxidant, antimicrobial, and anticancer activities of ethanolic extracts (EEs) and essential oils (E ...
DOI:: 10.1186/s12906-019-2556-y
PubMed:: 31227024
PubMed Central:: PMC6588939
: https://doi.org/10.1186/s12906-019-2556-y

31. Chemical composition and biological activities of essential oil isolated by HS-SPME and UAHD from fruits of bergamot

Author:: Chen Xing; Chunqing Qin; Xueqing Li; Fuming Zhang; Robert J. Linhardt; Peilong Sun; Anqiang Zhang
Source:: Lebensmittel-Wissenschaft + Technologie 2019 v.104 pp. 38-44
ISSN:: 0023-6438
Subject:: Citrus medica; Escherichia coli; antimicrobial properties; antineoplastic activity; antioxidant activity; bacteria; blood circulation; chemical composition; essential oils; fruit peels; fruits; fungi; gamma-terpinene; gas chromatography-mass spectrometry; headspace analysis; hydrodistillation; limonene; minimum inhibitory concentration; oils; solid phase microextraction; ultrasonic treatment; volatile compounds
Abstract:: ... Bergamot essential oil (BEO), which is extracted from bergamot fruit peel, has many health benefits such as improving blood circulation and anticancer activity. In this paper, volatile components were obtained by headspace solid phase microextraction (HS-SPME) and ultrasound-assisted hydrodistillation (UAHD) from the fruits of bergamot (Citrus medica L. var. sarcodactylis (Noot.) Swingle). The oil ...
DOI:: 10.1016/j.lwt.2019.01.020
: https://doi.org/10.1016/j.lwt.2019.01.020

32. Chemical composition and in vitro bioactivity of essential oil obtained from the flavedo of ‘Pompia’, an ancient Sardinian fruit

Author:: Antonella Rosa; Mariella Nieddu; Giacomo Luigi Petretto; Giorgia Sarais
Source:: Journal of essential oil research 2019 v.31 no.5 pp. 390-399
ISSN:: 2163-8152
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Citrus limon; antineoplastic activity; antioxidant activity; beta-carotene; bleaching; chemical composition; cytotoxicity; dietary supplements; essential oils; free radicals; fruits; gas chromatography; high performance liquid chromatography; hydrodistillation; limonene; linoleic acid; liqueurs; metabolites; neoplasm cells; pastries; phospholipids; viability; Italy; Sardinia
Abstract:: ... Pompia (Citrus limon var. pompia) grows in the North-East Sardinia (Italy). This fruit is used in traditional pastries, the flavedo for the preparation of liqueurs by hydroalcoholic infusion. We investigated the chemical composition and bioactivity of the essential oil obtained by hydro-distillation from the peel of pompia (PEO). Gas chromatographic analysis allowed us to determine the PEO chemica ...
DOI:: 10.1080/10412905.2019.1606740
: https://doi.org/10.1080/10412905.2019.1606740

33. Chemical composition, antioxidant activity and antitumor activity of tumorous stem mustard leaf and stem extracts

Author:: Wenfeng Li; Hongyan Yang; Changman Li; Si Tan; Xiaoxv Gao; Min Yao; Qiaoran Zheng
Source:: CyTA: journal of food 2019 v.17 no.1 pp. 272-279
ISSN:: 1947-6345
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Brassica juncea var. tumida; antineoplastic activity; antioxidant activity; cell growth; chemical composition; diet; dose response; free radicals; isorhamnetin; leaf extracts; leaves; lung neoplasms; luteolin; neoplasm cells; oxidative stress; polyphenols; quercetin; raw materials; stem extracts; sulfonic acids
Abstract:: ... The swollen succulent stem of tumorous stem mustard (Brassica juncea var. tumida Tsen et Lee) is the raw material in the processing of Chinese Fuling zhàcài. We found that total polyphenols and flavonoids contents of tumorous stem mustard leaf extracts (TSMLE) were significant higher than that of tumorous stem mustard stem extracts (TSMSE). The percentage of isorhamnetin 5-O-hexoside, methyl querc ...
DOI:: 10.1080/19476337.2019.1577303
: https://doi.org/10.1080/19476337.2019.1577303

34. Chemical structure and biological properties of a polysaccharide isolated from Pleurotus sajor-caju

Author:: Palaniappan Seedevi; Abirami Ramu Ganesan; Kannan Mohan; Vasantharaja Raguraman; Murugesan Sivakumar; Palaniappan Sivasankar; Sivakumar Loganathan; Palasundaram Rajamalar; Shanmugam Vairamani; Annaian Shanmugam
Source:: RSC advances 2019 v.9 no.35 pp. 20472-20482
ISSN:: 2046-2069
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Pleurotus sajor-caju; anion exchange; antineoplastic activity; antioxidant activity; ash content; carbon; chemical structure; chromatography; fractionation; gels; human cell lines; humans; hydrogen; hydroxyl radicals; molecular weight; neoplasm cells; nitrogen content; permeability; pharmaceutical industry; polysaccharides; protein content; superoxide anion; water content
Abstract:: ... Herein, a polysaccharide obtained from Pleurotus sajor-caju was fractionated via anion-exchange column chromatography and purified using gel permeation column chromatography. The chemical characterization of the polysaccharide indicated that it contained 90.16% total carbohydrate, 0% protein, 12.7% ash and 5.2% moisture; on the other hand, the carbon, hydrogen and nitrogen contents were found to b ...
DOI:: 10.1039/c9ra02977j
: https://doi.org/10.1039/c9ra02977j

35. Combined Nutraceuticals: A Novel Approach to Colitis-Associated Colorectal Cancer?

Author:: Lauren C. Chartier; Gordon S. Howarth; Suzanne Mashtoub
Source:: Nutrition and cancer 2019 v.71 no.2 pp. 199-206
ISSN:: 1532-7914
Subject:: animal fats and oils; antineoplastic activity; antioxidant activity; colitis; colorectal neoplasms; diarrhea; emus; etiology; functional foods; grape seed extract; ingredients; intestines; medicine; models; neoplasm cells; pain; patients; therapeutics; Japan
Abstract:: ... Ulcerative colitis is an unremitting and lifelong inflammatory bowel disease that is increasing in prevalence worldwide. Patients display various clinical symptoms such as abdominal pain, diarrhea and fatigue. The etiology of ulcerative colitis remains unknown and the current pharmaceutical treatments are variably effective and not curative, highlighting the need for improved therapeutic approache ...
DOI:: 10.1080/01635581.2019.1578391
: https://doi.org/10.1080/01635581.2019.1578391

36. Comparison of the Effect of Native 1,4-Naphthoquinones Plumbagin, Menadione, and Lawsone on Viability, Redox Status, and Mitochondrial Functions of C6 Glioblastoma Cells

Author:: Daiva Majiene; Jolita Kuseliauskyte; Arturas Stimbirys; Aiste Jekabsone
Source:: Nutrients 2019 v.11 no.6 pp. -
ISSN:: 2072-6643
Subject:: antineoplastic activity; antioxidant activity; cell viability; cytotoxicity; energy expenditure; fluorescence; glioblastoma; juglone; menadione; mitochondria; necrosis; oxidation; oxidative phosphorylation; oxygen; plumbagin; propidium; staining
Abstract:: ... Background: 1,4-naphthoquinones, especially juglone, are known for their anticancer activity. However, plumbagin, lawsone, and menadione have been less investigated for these properties. Therefore, we aimed to determine the effects of plumbagin, lawsone, and menadione on C6 glioblastoma cell viability, ROS production, and mitochondrial function. Methods: Cell viability was assessed spectrophotomet ...
DOI:: 10.3390/nu11061294
PubMed:: 31181639
PubMed Central:: PMC6628372
: https://doi.org/10.3390/nu11061294

37. Composition, antioxidant capacity and cytotoxic activity of Eugenia uniflora L. chemotype-oils from the Amazon

Author:: Pablo Luis B. Figueiredo; Laine C. Pinto; Jamile S. da Costa; Alberto Ray C. da Silva; Rosa Helena V. Mourão; Raquel C. Montenegro; Joyce Kelly R. da Silva; José Guilherme S. Maia
Source:: Journal of ethnopharmacology 2019 v.232 pp. 30-38
ISSN:: 0378-8741
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Eugenia uniflora; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; cell movement; chemical composition; chemotypes; cytotoxicity; dimethyl sulfoxide; drugs; fibroblasts; gas chromatography-mass spectrometry; germacrene; human cell lines; humans; hydrodistillation; inhibitory concentration 50; melanoma; neoplasm cells; oils; phytotherapy; traditional medicine; Amazonia; Brazil
Abstract:: ... Oils and extracts of Eugenia uniflora have been reported as antimicrobial, antifungal, antinociceptive, antiprotozoal, antioxidant and cytotoxic.The oils of five specimens (E1 to E5) that occur in the Brazilian Amazon were extracted, analyzed for their chemical composition, and submitted to antioxidant and cytotoxic assays.Oils were hydrodistilled, analyzed by GC and GC-MS, and submitted to PCA an ...
DOI:: 10.1016/j.jep.2018.12.011
: https://doi.org/10.1016/j.jep.2018.12.011

38. Comprehensive review of antimicrobial activities of plant flavonoids

Author:: Ireneusz Górniak; Rafał Bartoszewski; Jarosław Króliczewski
Source:: Phytochemistry reviews 2019 v.18 no.1 pp. 241-272
ISSN:: 1568-7767
Subject:: antibiotic resistance; antibiotics; antimicrobial properties; antineoplastic activity; antioxidant activity; bacteria; biofilm; coronary disease; disease prevention; drugs; flavonoids; free radical scavengers; health services; humans; industry; secondary metabolites; virulence
Abstract:: ... Flavonoids are one of the largest classes of small molecular secondary metabolites produced in different parts of the plant. They display a wide range of pharmacological and beneficial health effects for humans, which include, among others, antioxidative activity, free radical scavenging capacity, coronary heart disease prevention and antiatherosclerotic, hepatoprotective, anti-inflammatory, and a ...
DOI:: 10.1007/s11101-018-9591-z
: https://doi.org/10.1007/s11101-018-9591-z

39. Construction of doxorubicin-conjugated lentinan nanoparticles for enhancing the cytotoxocity effects against breast cancer cells

Author:: Ying Wang; Jingwen Chen; Qianqian Han; Qiang Luo; Hongmei Zhang; Yanqing Wang
Source:: Colloids and surfaces 2019 v.579 pp. 123657
ISSN:: 0927-7757
Subject:: adverse effects; antineoplastic activity; antioxidant activity; breast neoplasms; doxorubicin; drug therapy; glycemic effect; humans; nanoparticles; neoplasm cells; pH; phosphates; rheology; screening
Abstract:: ... Lentinan(LNT) has many kinds of pharmacological activities such as antioxidative activities, hypoglycemic effect, anti-hyperlipidemic effect and so on. Here, LNT was used as the skeleton material to couple with doxorubicin(DOX) by forming the LNT–DOX conjugates in order to enhance anticancer effects and reduce the systemic side effects of DOX. Based on the screening results, we observed that LNT c ...
DOI:: 10.1016/j.colsurfa.2019.123657
: https://doi.org/10.1016/j.colsurfa.2019.123657

40. Could volatile compounds from leaves and fruits of Pistacia lentiscus constitute a novel source of anticancer, antioxidant, antiparasitic and antibacterial drugs?

Author:: Abdelhakim Bouyahya; Inès Christelle Chadon Assemian; Houda Mouzount; Ilhame Bourais; Abdeslam Et-Touys; Hajiba Fellah; Abdelaziz Benjouad; Nadia Dakka; Youssef Bakri
Source:: Industrial crops and products 2019 v.128 pp. 62-69
ISSN:: 0926-6690
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Leishmania infantum; Leishmania major; Leishmania tropica; Pistacia lentiscus; Proteus mirabilis; Pseudomonas aeruginosa; adenocarcinoma; alpha-pinene; alternative medicine; antibacterial properties; antibiotics; antineoplastic activity; antioxidant activity; antioxidants; antiparasitic agents; antiparasitic properties; bioactive compounds; cell lines; cytotoxicity; essential oils; fruits; gas chromatography-mass spectrometry; inhibitory concentration 50; leaves; limonene; membrane permeability; myrcene; volatile compounds
Abstract:: ... Essential oils possess remarkable biological properties, which constitute an important source for the development of bioactive compounds used in alternative medicine. This work aimed to determine the volatile compounds Pistacia lentiscus L. essential oils extracted from leaves and fruits and to evaluate their anticancer, antioxidant, antibacterial and antiparasitic activities. The gas chromatograp ...
DOI:: 10.1016/j.indcrop.2018.11.001
: https://doi.org/10.1016/j.indcrop.2018.11.001

41. Cytogenotoxic effect, phytochemical screening and antioxidant potential of Jatropha mollissima (Pohl) Baill leaves

Author:: W.L.F. Dias; E.P. do Vale Junior; M. das Dores Alves de Oliveira; Y.L.P. Barbosa; J. do Nascimento Silva; J.S. da Costa Júnior; P.M. de Almeida; F.A. Martins
Source:: South African journal of botany 2019 v.123 pp. 30-35
ISSN:: 0254-6299
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Allium cepa; Jatropha; antineoplastic activity; antioxidant activity; cytotoxicity; ethyl acetate; flavanols; flavonols; free radical scavengers; genotoxicity; hexane; leaves; methanol; mitosis; saponins; screening; tannins; triterpenoids; xanthones
Abstract:: ... Phytochemical profile, antioxidant potential, total phenolic content and cytogenotoxic effect (Allium cepa test) were assessed in hexane (HE), ethyl acetate (EA) and methanol (ME) extracts of Jatropha mollissima leaves. Phytochemical analysis revealed the presence of triterpenes in HE, which were also observed in conjunction with flavonoids in EA. Saponins, catechins, phenols, tannins, flavonoids, ...
DOI:: 10.1016/j.sajb.2019.02.007
: https://doi.org/10.1016/j.sajb.2019.02.007

42. Cytotoxic and cell cycle arrest induction of pentacyclic triterpenoides separated from Lantana camara leaves against MCF-7 cell line in vitro

Author:: Zahraa R. Shamsee; Ali Z. Al-Saffar; Ahmed F. Al-Shanon; Jameel R. Al-Obaidi
Source:: Molecular biology reports 2019 v.46 no.1 pp. 381-390
ISSN:: 0301-4851
Subject:: Lantana camara; active ingredients; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; caspase-9; cell cycle checkpoints; cell lines; cell viability; cytotoxicity; dose response; inhibitory concentration 50; interphase; leaves; liquid chromatography; medicinal plants; tandem mass spectrometry; triterpenoids
Abstract:: ... Lantana camara is an important medicinal plant that contains many active compounds, including pentacyclic triterpenoids, with numerous biological activities. The present study was conducted to evaluate the anti-oxidant, anti-tumour, and cell cycle arrest properties of chemical compounds extracted from L. camara leaves. Four compounds were identified after subjecting the plant methanolic extract to ...
DOI:: 10.1007/s11033-018-4482-3
: https://doi.org/10.1007/s11033-018-4482-3

43. Determination of phenolic compounds, antioxidant and anticancer activity of Chrozophora tinctoria accessions collected from different regions of Iran

Author:: Pooran Golkar; Marzieh Taghizadeh; Seyed Amir Hossein Jalali
Source:: Journal of food biochemistry 2019 v.43 no.11 pp. e13036
ISSN:: 0145-8884
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Chrozophora; anthocyanins; antineoplastic activity; antioxidant activity; antioxidants; cancer therapy; carotenoids; carvacrol; catechin; dietary supplements; ellagic acid; enzyme activity; enzymes; eugenol; hesperetin; hesperidin; high performance liquid chromatography; human cell lines; kaempferol; neoplasms; quercetin; rosmarinic acid; thymol; Iran
Abstract:: ... The present study was conducted to determine the total phenolics, flavonoids, flavonols, anthocyanin, and carotenoids as well as the antioxidant activity of 10 different Crozophora tinctoria accessions originated from Iran. The highest contents of total phenolics, flavonoids, flavonols, anthocyanin, and carotenoids were detected in C.t (2), C.t (10), C.t (10), C.t (9), and C.t (3) accessions, resp ...
DOI:: 10.1111/jfbc.13036
: https://doi.org/10.1111/jfbc.13036

44. Development of Ganoderma lucidum spore powder based proteoglycan and its application in hyperglycemic, antitumor and antioxidant function

Author:: Li-Fang Zhu; Yuanfa Yao; Zeeshan Ahmad; Ming-Wei Chang
Source:: Process biochemistry 2019 v.84 pp. 103-111
ISSN:: 1359-5113
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Escherichia coli; Ganoderma lucidum; Staphylococcus aureus; amino acids; antibacterial properties; antineoplastic activity; antioxidant activity; ion exchange chromatography; molecular weight; monosaccharides; polyacrylamide gel electrophoresis; proteoglycans; response surface methodology; solvents; spores; therapeutics
Abstract:: ... A new natural proteoglycan from Ganoderma lucidum spore powder (GLSP) was obtained via solvent extraction and optimized using response surface methodology (RSM). The differences among the characteristics of the new proteoglycan from cracked (proteoglycan-C) and uncracked GLSP (proteoglycan-UC) were explored. The SDS-PAGE results showed the molecular weight of protein contained in proteoglycan-UC ( ...
DOI:: 10.1016/j.procbio.2019.05.025
: https://doi.org/10.1016/j.procbio.2019.05.025

45. Dietary zerumbone from shampoo ginger: new insights into its antioxidant and anticancer activity

Author:: A. Rosa; D. Caprioglio; R. Isola; M. Nieddu; G. Appendino; A. M. Falchi
Source:: Food & function 2019 v.10 no.3 pp. 1629-1642
ISSN:: 2042-650X
Subject:: antineoplastic activity; antioxidant activity; antioxidants; apoptosis; cholesterol; droplets; fatty acid composition; fluorescence; free radicals; ginger; lipid peroxidation; mitochondria; mitochondrial membrane; neoplasm cells; neoplasms; oleic acid; oxidation; oxidative stress; palmitic acid; phospholipids; sesquiterpenoids; staining; stearic acid
Abstract:: ... The dietary sesquiterpene dienone zerumbone (ZER) selectively targets cancer cells, inducing mitochondrial dysfunction and apoptosis, and protects non-cancerous cells towards oxidative stress and insult. This study examines the in vitro effects of ZER on lipid peroxidation in biological systems (cholesterol and phospholipid membrane oxidation) and explores its antitumor action in terms of its abil ...
DOI:: 10.1039/c8fo02395f
: https://doi.org/10.1039/c8fo02395f

46. ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress

Author:: Sung-Yong Yang; Min Cheol Pyo; Mi-Hyun Nam; Kwang-Won Lee
Source:: BMC complementary and alternative medicine 2019 v.19 no.1 pp. 139
ISSN:: 1472-6882
Subject:: alternative medicine; analysis of variance; antineoplastic activity; antioxidant activity; antioxidants; binding sites; caffeic acid; cell nucleus; cell viability; cytoplasm; gene expression; gene expression regulation; genes; glutamate-cysteine ligase; heme oxygenase (biliverdin-producing); hepatoprotective effect; human cell lines; humans; liver; messenger RNA; mitogen-activated protein kinase; oxidative stress; phosphorylation; phytochemicals; proteins
Abstract:: ... BACKGROUND: Several studies have found that caffeic acid (CA), a well-known phytochemical, displays important antioxidant and anti-cancer activities. However, no evidence exists on the protective effect and its mechanisms that CA treatment alone has against oxidative stress induced by tert-butyl hydroperoxide (t-BHP) in HepG2 cells. METHODS: Hepatoprotective activities such as cell viability, mRNA ...
DOI:: 10.1186/s12906-019-2551-3
PubMed:: 31221142
PubMed Central:: PMC6585055
: https://doi.org/10.1186/s12906-019-2551-3

47. Effects of domestic cooking process on the chemical and biological properties of dietary phytochemicals

Author:: Chao Zhao; Yuanyuan Liu; Shanshan Lai; Hui Cao; Yi Guan; Wai San Cheang; Bin Liu; Kewei Zhao; Song Miao; Céline Riviere; Esra Capanoglu; Jianbo Xiao
Source:: Trends in food science & technology 2019 v.85 pp. 55-66
ISSN:: 0924-2244
Subject:: antineoplastic activity; antioxidant activity; ascorbic acid; bioavailability; carotenoids; chlorophyll; cooking; crude fat; dietary fiber; dietary supplements; digestibility; flavonols; foods; functional properties; glucosinolates; humans; minerals; nutrients; nutritive value; palatability; polyphenols
Abstract:: ... Foods are good sources of vitamins, minerals and dietary fibers as well as phytochemicals, which are beneficial for the human body as nutritional supplements. The nutritional value (crude fibers, crude proteins, crude fats, flavonols, carotenoids, polyphenols, glucosinolate, chlorophyll, and ascorbic acid) and biological or functional properties (antioxidant activity, anticancer activity, or anti- ...
DOI:: 10.1016/j.tifs.2019.01.004
: https://doi.org/10.1016/j.tifs.2019.01.004

48. Ellagic acid ameliorates cisplatin induced hepatotoxicity in colon carcinogenesis

Author:: Yasmeen Goyal; Ashwani Koul; Pavitra Ranawat
Source:: Environmental toxicology 2019 v.34 no.7 pp. 804-813
ISSN:: 1520-4081
Subject:: Fourier transform infrared spectroscopy; adverse effects; antineoplastic activity; antioxidant activity; carcinogenesis; chemoprevention; cisplatin; colon; colorectal neoplasms; ellagic acid; hepatotoxicity; histopathology; lactate dehydrogenase; liver; mice; microorganisms; oxidative stress; polyphenols; reactive oxygen species
Abstract:: ... The clinical application of cisplatin (CP), one of the most extensively used antineoplastic drug, is restricted by its numerous side effects. CP's antitumor potential resides in the free generation of reactive oxygen species leading to oxidative stress. This stress is a source of the side effects associated with its use. Ellagic acid (EA), a polyphenol is known to possess multiple health benefits ...
DOI:: 10.1002/tox.22747
: https://doi.org/10.1002/tox.22747

49. Engineered Polymeric Micelles for Combinational Oxidation Anticancer Therapy through Concurrent HO-1 Inhibition and ROS Generation

Author:: Joungyoun Noh; Eunkyeong Jung; Jeonghun Lee; Hyejin Hyun; Seri Hong; Dongwon Lee
Source:: Biomacromolecules 2019 v.20 no.2 pp. 1109-1117
ISSN:: 1526-4602
Subject:: antineoplastic activity; antioxidant activity; apoptosis; aqueous solutions; bilirubin; body weight changes; heme oxygenase (biliverdin-producing); homeostasis; micelles; neoplasm cells; neoplasms; oxidation; oxidative stress; polymers; protoporphyrin; reactive oxygen species; therapeutics; toxicity
Abstract:: ... Cancer cells have a large amount of ROS (reactive oxygen species) because of disturbed ROS homeostasis. Cancer cells therefore undertake redox adaptation to drive proliferation in tumor environments and even survive during anticancer treatment by upregulating endogenous antioxidants. As one of antioxidant defense systems, heme oxygenase-1 (HO-1) acts as an essential role in tumor development by of ...
DOI:: 10.1021/acs.biomac.8b01802
: https://doi.org/10.1021/acs.biomac.8b01802

50. Enzymatic treatment improves the antioxidant and antiproliferative activities of Adenanthera pavonina L. seeds

Author:: Nayara Macêdo Peixoto Araujo; Gustavo Araujo Pereira; Henrique Silvano Arruda; Lívia Garcia Prado; Ana Lúcia Tasca Gois Ruiz; Marcos Nogueira Eberlin; Ruann Janser Soares de Castro; Glaucia Maria Pastore
Source:: Biocatalysis and agricultural biotechnology 2019 v.18 pp. 101002
ISSN:: 1878-8181
Subject:: Adenanthera pavonina; amylases; antineoplastic activity; antioxidant activity; drugs; endo-1,4-beta-glucanase; enzymatic treatment; functional foods; functional properties; kidneys; neoplasms; phenolic acids; proteinases; seeds
Abstract:: ... We evaluated the effect of enzymatic treatment by amylase, cellulase and protease on antioxidant and antiproliferative activities of Adenanthera pavonina L. seeds. The effect was evaluated by using an experimental mixture design. The results showed that the antioxidant activity of the seeds increased after the enzymatic treatment. The enzymatic treatment using protease and cellulase (1:1, v/v) sho ...
DOI:: 10.1016/j.bcab.2019.01.040
: https://doi.org/10.1016/j.bcab.2019.01.040

51. Essential Oil Composition and Biological Activities of Aegle marmelos (L.) Correa Grown in Western Ghats Region-South India

Author:: Kathirvel Poonkodi; Krishnasamy Vimaladevi; Murugesan Suganthi; Neelakrishnan Gayathri
Source:: Journal of essential oil-bearing plants 2019 v.22 no.4 pp. 1013-1021
ISSN:: 0976-5026
Subject:: Aegle marmelos; antineoplastic activity; antioxidant activity; chemical composition; essential oils; humans; hydrodistillation; kidneys; limonene; monkeys; neoplasm cells; oils; reactive oxygen species; uterine cervical neoplasms; India
Abstract:: ... The present study aimed to evaluate the chemical composition of essential oil of Aegle marmelos (L.) grown in Western Ghats region. The hydrodistilled essential oil was analyzed by GC/MS and yield of the oil was (0.9% v/w). A total of 31 components was identified, represents 97.44% of the oil. The major components of essential oil from Western Ghats were p-mentha-1,4(8)-diene (33.2%), limonene (13 ...
DOI:: 10.1080/0972060X.2019.1653796
: https://doi.org/10.1080/0972060X.2019.1653796

52. Evaluation of antibacterial and anticancer properties of poly(3-hydroxybutyrate) functionalized with different amino compounds

Author:: Mohamed A. Abdelwahab; Ahmed A. El-Barbary; Karim S. El-Said; Sabry A. El Naggar; Hazem M. ElKholy
Source:: International journal of biological macromolecules 2019 v.122 pp. 793-805
ISSN:: 0141-8130
Subject:: Escherichia coli; Fourier transform infrared spectroscopy; Klebsiella pneumoniae; Pseudomonas aeruginosa; X-ray diffraction; amino compounds; antibacterial properties; antineoplastic activity; antioxidant activity; antioxidants; biodegradability; carcinoma; crystal structure; mice; morpholine; nuclear magnetic resonance spectroscopy; organochlorine compounds; piperazine; polymers; transesterification
Abstract:: ... The chemical modification of biodegradable poly(3-hydroxybutyrate) (PHB) is useful for biomedical applications. In this study, the transesterification reaction of PHB was carried out under reflux conditions in the presence of 1,4-butanediol to form telechelic PHB-diol. Further modification of PHB-diol into PHB-diacrylate was carried out by the reaction of PHB-diol with acryloyl chloride. PHB-diacr ...
DOI:: 10.1016/j.ijbiomac.2018.10.164
: https://doi.org/10.1016/j.ijbiomac.2018.10.164

53. Exopolysaccharides from the fungal endophytic Fusarium sp. A14 isolated from Fritillaria unibracteata Hsiao et KC Hsia and their antioxidant and antiproliferation effects

Author:: Feng Pan; Kai Hou; Dan-Dan Li; Tian-Jiao Su; Wei Wu
Source:: Journal of bioscience and bioengineering 2019 v.127 no.2 pp. 231-240
ISSN:: 1389-1723
Subject:: Fritillaria; Fusarium; agarose; antineoplastic activity; antioxidant activity; antioxidants; arabinose; endophytes; ethanol; exopolysaccharides; fungi; galactose; gel chromatography; glucose; hepatoma; hepatoprotective effect; human cell lines; humans; immunostimulants; ion exchange chromatography; mannose; rhamnose; water solubility; xylose
Abstract:: ... Exopolysaccharides (EPSs) are high-molecular-weight carbohydrates with a wide range of biophysiological activities, such as antioxidant activity, immunostimulatory activity, antitumor activity, hepatoprotective activity, and antifatigue effects. In the present work, two water-soluble EPSs, namely, A14EPS-1 and A14EPS-2, were isolated and purified from the fungal endophytic strain A14 using ethanol ...
DOI:: 10.1016/j.jbiosc.2018.07.023
: https://doi.org/10.1016/j.jbiosc.2018.07.023

54. Exploitation of apple pomace towards extraction of triterpenic acids, antioxidant potential, cytotoxic effects, and inhibition of clinically important enzymes

Author:: Shivraj Hariram Nile; Arti Nile; Junqiu Liu; Doo Hwan Kim; Guoyin Kai
Source:: Food and chemical toxicology 2019 v.131 pp. 110563
ISSN:: 0278-6915
Subject:: allopurinol; antineoplastic activity; antioxidant activity; antioxidants; apple pomace; betulinic acid; cell lines; chloroform; cytotoxicity; ethanol; ethyl acetate; functional foods; hexane; inhibitory concentration 50; kojic acid; methanol; neoplasm cells; neoplasms; tandem mass spectrometry; thiourea; urease; ursolic acid; xanthine oxidase
Abstract:: ... Apple pomace (AP) utilised for analysis of triterpenic acids (TTAs) using HPLC-MS/MS. The methanol, ethanol and ethyl acetate extracts showed high phenolic content with significant antioxidant activity compared to chloroform and n-hexane. AP TTAs; ursolic acid, betulinic acid and maslinic acid showed potent antioxidant and enzyme inhibitory effects. The IC50 values were 13.2–30.8 μg/mL (tyrosinase ...
DOI:: 10.1016/j.fct.2019.110563
: https://doi.org/10.1016/j.fct.2019.110563

55. Extracts of Hypsizygus tessellatus (white var.) caps inhibited MCF-7 and MDA-MB-231 cell lines proliferation

Author:: C. I. Ukaegbu; S. R. Shah; H. A. Hamid; Z. Normaiza; O. R. Alara
Source:: Journal of food measurement & characterization 2019 v.13 no.1 pp. 368-382
ISSN:: 2193-4126
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Hypsizygus; acetone; adverse effects; antineoplastic activity; antineoplastic agents; antioxidant activity; breast neoplasms; breasts; cell lines; chemical constituents of plants; drug therapy; ethyl acetate; free radical scavengers; hydrogen peroxide; inhibitory concentration 50; liquid chromatography; mass spectrometry; neoplasm cells
Abstract:: ... Cancer management is associated with serious side-effects due to the harmful nature of radiation and chemotherapy on the body cells. These side-effects have necessitated the need for diversifying the alternative or complementary sources of cancer therapy. Natural products have been on the front line as alternative sources of anticancer agents and have attracted much attention in recent times. In t ...
DOI:: 10.1007/s11694-018-9952-8
: https://doi.org/10.1007/s11694-018-9952-8

56. Gas chromatography-mass spectrometry analysis and antimicrobial, antioxidant and anti-cancer activities of essential oils and extracts of Stachys schtschegleevii plant as biological macromolecules

Author:: Shekofe Nasrollahi; Sayed Mehdi Ghoreishi; Abdolrasoul H. Ebrahimabadi; Asma Khoobi
Source:: International journal of biological macromolecules 2019 v.128 pp. 718-723
ISSN:: 0141-8130
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Artemia; Stachys; antimicrobial properties; antineoplastic activity; antioxidant activity; butylated hydroxytoluene; chemical composition; death; essential oils; ethyl acetate; flavonoids; gas chromatography-mass spectrometry; hydrogen peroxide; inhibitory concentration 50; iron; leaf extracts; leaves; lethal concentration 50; minimum inhibitory concentration; steam distillation
Abstract:: ... This work reports the chemical composition and antimicrobial activity of the essential oil as well as antioxidant and anti-cancer activities of ethyl acetate and aqueous extracts from leaf and stem of Stachys schtschegleevii. The structure of volatile parts and effective phenolic compounds as biological macromolecules as well as biological activity of the Stachys schtschegleevii plant were studied ...
DOI:: 10.1016/j.ijbiomac.2019.01.165
: https://doi.org/10.1016/j.ijbiomac.2019.01.165

57. Glucosinolates metabolism and redox state of rocket (Eruca sativa Mill.) during germination

Author:: Mian Wang; Yuxuan Zhang; Chaoqun Leng; Xinyue Li; Pei Wang; Zhenxin Gu; Runqiang Yang
Source:: Journal of food processing and preservation 2019 v.43 no.8 pp. e14019
ISSN:: 0145-8892
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Eruca vesicaria subsp. sativa; anthocyanins; antineoplastic activity; antioxidant activity; antioxidants; bioactive compounds; cardioprotective effect; catalytic activity; chlorophyll; cultivars; diet; germination; glucosinolates; human health; isothiocyanates; metabolism; raw materials; seeds; thioglucosidase; vegetables
Abstract:: ... Isothiocyanates (ITCs) exhibit anticancer and antioxidant activity. ITCs are formed from the catalysis of glucosinolates (GLs) by myrosinase (MYR) in Brassicaceae vegetables. This study investigated the GL content, MYR activity, ITC formation, and redox state of rocket upon germination. Banye and Dongsheng were selected from four cultivars by determining growth state and ITC metabolism. In both cu ...
DOI:: 10.1111/jfpp.14019
: https://doi.org/10.1111/jfpp.14019

58. Green Tea Extract (Camellia sinensis) as a Potential Antitumoral Agent on Breast Cancer Cells (FS13-04-19)

Author:: Danielly Costa; Ronimara Santos; Emmanuele Da Silva Andrade; Beatriz Louise Themistocles; Brenda Graziella da Silva; Eliane Fialho; Mariana Monteiro; Jerson Silva; Julio Daleprane
Source:: Current developments in nutrition 2019 v.3 no.Supplement_1 pp. -
ISSN:: 2475-2991
Subject:: Camellia sinensis; Western blotting; anticarcinogenic activity; antineoplastic activity; antioxidant activity; boiling; breast neoplasms; cell culture; cell viability; cytotoxicity; flavanols; freeze drying; green tea; human cell lines; immunocytochemistry; inhibitory concentration 50; neoplasm cells; polyphenols; protein content; signal transduction; temperature; tumor suppressor protein p53
Abstract:: ... We aimed to obtain a catechin-rich green tea extract (GTE) from Camellia sinensis and to evaluate its antitumor potential on human breast cancer. Green tea (GT) has been extensively studied for its antioxidant property, which is mainly attributed to catechins. These phenolic compounds regulate many cellular targets involved in cancer signaling pathways, including those mediated by p53 tumor suppre ...
DOI:: 10.1093/cdn/nzz030.FS13-04-19
: https://doi.org/10.1093/cdn/nzz030.FS13-04-19

59. Green synthesis of silver nanoparticles at low temperature in a fast pace with unique DPPH radical scavenging and selective cytotoxicity against MCF-7 and BT-20 tumor cell lines

Author:: Sadegh Khorrami; Atefeh Zarepour; Ali Zarrabi
Source:: Biotechnology reports 2019 v.24 pp. e00393
ISSN:: 2215-017X
Subject:: 2,2-diphenyl-1-picrylhydrazyl; ambient temperature; antineoplastic activity; antioxidant activity; biosynthesis; breast neoplasms; cell death; cell lines; cultivars; cytotoxicity; free radicals; median effective concentration; nanoparticles; nanosilver; neoplasm cells; pomegranates
Abstract:: ... "Black Peel Pomegranate" is a rare pomegranate cultivar that its specific features are still uncovered particularly in the bio-nano researches. The present study was organized to evaluate this pomegranate's potential in the biosynthesis of silver nanoparticles as well as bio-medical activities. According to the results, the pomegranate peel extract incredibly inhibited 100 % of DPPH free radicals ...
DOI:: 10.1016/j.btre.2019.e00393
PubMed:: 31763203
PubMed Central:: PMC6864360
: https://doi.org/10.1016/j.btre.2019.e00393

60. Immunomodulatory and Antioxidant Activities of Sulfated Polysaccharides from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum

Author:: Roberto T. Abdala Díaz; V. Casas Arrojo; M. A. Arrojo Agudo; C. Cárdenas; S. Dobretsov; F. L. Figueroa
Source:: Marine biotechnology 2019 v.21 no.4 pp. 577-587
ISSN:: 1436-2228
Subject:: Gelidium; Laminaria; Porphyra; adenocarcinoma; antineoplastic activity; antioxidant activity; antioxidants; breast neoplasms; breasts; cell lines; coasts; colorectal neoplasms; humans; immunomodulators; inhibitory concentration 50; leukemia; macroalgae; macrophage activation; melanoma; metabolites; mice; nonfood industry; pharmaceutical industry; polysaccharides; Spain
Abstract:: ... Seaweeds of the genera Laminaria, Gelidium, and Porphyra have been used in both food and non-food industries due to their unique properties and characteristic biological activity. This study assesses the antioxidant activity and immunomodulatory properties of the acidic polysaccharides extracted from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum collected in the Atlantic coast o ...
DOI:: 10.1007/s10126-019-09905-x
: https://doi.org/10.1007/s10126-019-09905-x

61. Impact of fermentation conditions on the production of bioactive compounds with anticancer, anti-inflammatory and antioxidant properties in kombucha tea extracts

Author:: Silvia Alejandra Villarreal-Soto; Sandra Beaufort; Jalloul Bouajila; Jean-Pierre Souchard; Thierry Renard; Serge Rollan; Patricia Taillandier
Source:: Process biochemistry 2019 v.83 pp. 44-54
ISSN:: 1359-5113
Subject:: anti-inflammatory activity; antineoplastic activity; antioxidant activity; antioxidants; bioactive compounds; black tea; colorectal neoplasms; ethyl acetate; fermentation; gas chromatography-mass spectrometry; geometry; human cell lines; humans; inhibitory concentration 50; kombucha; neoplasm cells; organic acids and salts; pH; phenolic compounds; solvents
Abstract:: ... The production of natural bioactive compounds through the fermentation of plants has increased in recent years. The biological activities of the extracts obtained from the fermentation of black tea with the kombucha consortium were evaluated. To improve the productivity of these compounds two different vessel geometries were used and successive extractions with solvents of increasing polarity were ...
DOI:: 10.1016/j.procbio.2019.05.004
: https://doi.org/10.1016/j.procbio.2019.05.004

62. Improved antioxidant, antimicrobial and anticancer activity of naringenin on conjugation with pectin

Author:: Jyoti Mundlia; Munish Ahuja; Pradeep Kumar; Viness Pillay
Source:: 3 Biotech 2019 v.9 no.8 pp. 312
ISSN:: 2190-572X
Subject:: Bacillus subtilis; Escherichia coli; Pseudomonas aeruginosa; Staphylococcus aureus; Staphylococcus epidermidis; X-ray diffraction; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; chromatography; cytotoxicity; differential scanning calorimetry; fluorescence emission spectroscopy; light scattering; molecular weight; naringenin; pH; pectins; polyphenols; therapeutics; water solubility
Abstract:: ... The purpose of the present study was to improve the aqueous solubility of naringenin by conjugating with water-soluble polysaccharide carrier, pectin. The pectin–naringenin conjugate was synthesized employing dicyclohexylcarbodiimide and dimethylaminopyridine. The conjugation was confirmed by various physicochemical characterizations. The results of differential scanning calorimetry, X-ray diffrac ...
DOI:: 10.1007/s13205-019-1835-0
PubMed:: 31406634
PubMed Central:: PMC6667600
: https://doi.org/10.1007/s13205-019-1835-0

63. In Vitro Analysis of Antioxidant, Anticancer, and Bioactive Components of Apocynum venetum Tea Extracts

Author:: Chong Li; Guangbin Huang; Fang Tan; Xianrong Zhou; Jianfei Mu; Xin Zhao
Source:: Journal of food quality 2019 v.2019 pp. -
ISSN:: 0146-9428
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Apocynum venetum; Oriental traditional medicine; antineoplastic activity; antioxidant activity; antioxidant genes; apoptosis; bioactive compounds; caspase-3; caspase-9; catalase; cell proliferation; cell viability; chlorogenic acid; cytotoxicity; dose response; free radical scavengers; free radicals; gene expression; gene expression regulation; glutathione peroxidase; hepatoma; high performance liquid chromatography; human cell lines; human diseases; hydrogen peroxide; in vitro studies; kidneys; leaves; messenger RNA; polyphenols; protective effect; quantitative polymerase chain reaction; quercetin; reverse transcriptase polymerase chain reaction; rosmarinic acid; rutin; spectroscopy; sulfonic acids; superoxide dismutase; survival rate; tea; toxicity testing
Abstract:: ... The dry leaf of Apocynum venetum tea extracts (AVTEs) belonging to the Apocynaceae family is a traditional Chinese medicine. The aim of this study is to identify the bioactive components of AVTE and analyse its antioxidant and anticancer activity in vitro. Method. Flavones and polyphenols in AVTE were determined by high-performance liquid chromatography (HPLC) assay. The scavenging capacity of tea ...
DOI:: 10.1155/2019/2465341
: https://doi.org/10.1155/2019/2465341

64. In vitro antioxidant, antidiabetic, antiacetylcholine esterase, anticancer activities and RP-HPLC analysis of phenolics from the wild bottle gourd (Lagenaria siceraria (Molina) Standl.)

Author:: U.A. Attar; S.G. Ghane
Source:: South African journal of botany 2019 v.125 pp. 360-370
ISSN:: 0254-6299
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Lagenaria siceraria; acetylcholinesterase; alpha-amylase; alpha-glucosidase; antineoplastic activity; antioxidant activity; cell lines; chemical constituents of plants; coumaric acids; drugs; enzyme inhibition; exocarp; flavonoids; glycemic effect; lethal concentration 50; mesocarp; metabolites; neoplasm cells; neoplasms; principal component analysis; reversed-phase high performance liquid chromatography; seed extracts; seeds; solvents; tannins; terpenoids; vanillic acid; vegetables
Abstract:: ... Lagenaria siceraria is the most popular and widely used fruit vegetable due to its immense health promoting properties. The aim of the present study was to evaluate phytochemicals and biological activities of the different fruit parts (epicarp, mesocarp and seeds) of wild bottle gourd extracted with acetone, ethanol, methanol and water. Present study highlighted that seeds extracted with ethanol s ...
DOI:: 10.1016/j.sajb.2019.08.004
: https://doi.org/10.1016/j.sajb.2019.08.004

65. In vitro cytotoxicity, antioxidant and anti-inflammatory activities of Pittosporum viridiflorum Sims and Hypoxis colchicifolia Baker used traditionally against cancer in Eastern Cape, South Africa

Author:: B. Madikizela; L.J. McGaw
Source:: South African journal of botany 2019 v.126 pp. 250-255
ISSN:: 0254-6299
Subject:: Hypoxis; Pittosporum viridiflorum; Salmonella Typhimurium; acetone; anti-inflammatory activity; antineoplastic activity; antioxidant activity; arachidonate 15-lipoxygenase; cattle; cytotoxicity; dermis; developing countries; drug development; drug resistance; ethanol; genotoxicity; inhibitory concentration 50; kidneys; lethal concentration 50; mechanism of action; monkeys; mutagens; neoplasm cells; neoplasms; paclitaxel; therapeutics; traditional medicine; vincristine; South Africa
Abstract:: ... Cancer is one of the leading causes of death both in developed and developing countries and was responsible for the loss of 9.6 million lives in 2018 alone. Development of drug resistant strains of cancer has hampered cancer therapy. Worldwide, plants have been reported to play a major role in the traditional treatment of cancer. Irinotecan, paclitaxel, and vincristine are some of the examples of ...
DOI:: 10.1016/j.sajb.2019.06.009
: https://doi.org/10.1016/j.sajb.2019.06.009

66. Inhibition of advanced glycation end products formation and inflammation in C. elegans: Studies of potential of Lyngbya sp. against expression of stress related genes and Live cell imaging

Author:: Rai Sameer Kumar; Ganeshan Shakambari; Balasubramaniem Ashokkumar; Perumal Varalakshmi
Source:: Biocatalysis and agricultural biotechnology 2019 v.17 pp. 233-241
ISSN:: 1878-8181
Subject:: Fourier transform infrared spectroscopy; Lyngbya; Nematoda; advanced glycation end products; animal models; animals; antineoplastic activity; antioxidant activity; antioxidants; fluorescence; fluorescence emission spectroscopy; gas chromatography-mass spectrometry; gene expression; gene expression regulation; genes; glucose; glycation; image analysis; inflammation; longevity; reverse transcriptase polymerase chain reaction; screening; secondary metabolites; stress response; therapeutics
Abstract:: ... Marine cyanobacteria Lyngbya sp. has been reported to produce many bioactive secondary metabolites which shows potent anti-oxidant, anti-inflammatory, anti-diabetic and anti-cancer activity. However, several potentials are yet to be unexplored. Hence in this study, ethanolic fraction (EF) of Lyngbya sp. was used to analyse its therapeutic potentials. The extract was collected and analyzed by Fouri ...
DOI:: 10.1016/j.bcab.2018.11.020
: https://doi.org/10.1016/j.bcab.2018.11.020

67. Inhibition of human breast cancer cells (MCF-7 cell line) growth via cell proliferation, migration, and angiogenesis by auraptene of Ferula szowitsiana root extract

Author:: Ensiyeh Charmforoshan; Ehsan Karimi; Ehsan Oskoueian; Ali Es-Haghi; Mehrdad Iranshahi
Source:: Journal of food measurement & characterization 2019 v.13 no.4 pp. 2644-2653
ISSN:: 2193-4126
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Ferula; angiogenesis; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; breast neoplasms; caspase-3; caspase-8; cell proliferation; chemoprevention; coumarins; cytotoxicity; drug therapy; enriched foods; food industry; free radicals; functional foods; gene expression regulation; genes; human cell lines; inhibitory concentration 50; neoplasm cells; root extracts; vascular endothelial growth factor receptor-1; vascular endothelial growth factor receptor-2; Central Asia; Iran
Abstract:: ... The different species of the Ferula (Apiaceae) genus are endemic in central Asia and are used as a medicinal food in Iran. The Ferula szowitsiana has been reported with anti-inflammatory, anti-hypertensive, anti-helicobacter, antileishmanial and cancer chemopreventive activities. Auraptene is one of the main coumarins from Ferula szowitsiana root. Despite the interesting biological properties of F ...
DOI:: 10.1007/s11694-019-00185-6
: https://doi.org/10.1007/s11694-019-00185-6

68. Isoorientin improves scopolamine-induced cognitive impairments by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling in the hippocampus and frontal cortex

Author:: Yong-Hyun Ko; Seung-Hwan Kwon; Seok-Yong Lee; Choon-Gon Jang
Source:: Archives of pharmacal research 2019 v.42 no.8 pp. 722-731
ISSN:: 0253-6269
Subject:: Western blotting; acetylcholinesterase; animal models; antineoplastic activity; antioxidant activity; antioxidants; cognitive disorders; cyclic AMP; flavonoids; frontal lobe; hippocampus; memory; mice; scopolamine; signal transduction; superoxide dismutase; thiobarbituric acid-reactive substances
Abstract:: ... Isoorientin (ISO) is considered one of the most important flavonoids with various pharmacological effects such as antioxidant, anti-inflammatory, and anti-cancer activities. Despite these beneficial activities, the effects of ISO on learning and memory have not been investigated so far. The current study evaluated the memory-enhancing effects of ISO in a scopolamine-treated mouse model by using th ...
DOI:: 10.1007/s12272-019-01172-7
: https://doi.org/10.1007/s12272-019-01172-7

69. Metabolic profiling and investigations on crude extract of Olea europaea L. leaves as a potential therapeutic agent against skin cancer

Author:: Debabrata Majumder; Mousumi Debnath; K.V. Libin Kumar; Priyatosh Nath; Rahul Debnath; Chaitali Sarkar; G.B.K.S. Prasad; Yogesh Kumar Verma; Debasish Maiti
Source:: Journal of functional foods 2019 pp. -
ISSN:: 1756-4646
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Olea europaea; antineoplastic activity; antioxidant activity; apigenin; apoptosis; bioactive compounds; cell lines; cytotoxicity; leaf extracts; liquid chromatography; luteolin; melanoma; metabolites; metabolomics; metastasis; mice; mitogen-activated protein kinase; myeloma; oleuropein; olives; skin neoplasms; tandem mass spectrometry; therapeutics
Abstract:: ... Olive (OleaeuropaeaL.) leaf extract (OLE) have shown therapeutic activity against different types of cancer. However, it is less known that olive leaf extract has anti myeloma activity. The in vitro cytotoxic activity of OLE was evaluated against mouse metastatic melanoma B16F10 cell lines. The extracts were analyzed for their antioxidant activity by DPPH radical scavenging activity and the presen ...
DOI:: 10.1016/j.jff.2019.05.005
: https://doi.org/10.1016/j.jff.2019.05.005

70. Multipurpose composite for heavy metal sorption, antimicrobial, and antioxidant applications

Author:: S. Olivera; C. Hu; G. S. Nagananda; N. Reddy; K. Venkatesh; H. B. Muralidhara
Source:: International journal of environmental science and technology 2019 v.16 no.4 pp. 2017-2030
ISSN:: 1735-1472
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Aegle marmelos; Streptococcus; adsorption; ambient temperature; antibacterial properties; antineoplastic activity; antioxidant activity; antioxidants; biocompatible materials; biodegradability; coliform bacteria; coprecipitation; filtrates; free radicals; heavy metals; hydroxides; lead; metal ions; oils; pH; proteins; water pollution; water purification
Abstract:: ... Magnesium–aluminum-layered double hydroxides (LDH) and proteins extracted from bael or bilva oil meal (BP) were used to form composites (LDH-BP) by a simple co-precipitation method. The synthesized composites were utilized to remove lead ions from contaminated water and to study the antimicrobial and antioxidant activities. BPs have inherent antimicrobial and anticancer properties and are biodegra ...
DOI:: 10.1007/s13762-018-1774-z
: https://doi.org/10.1007/s13762-018-1774-z

71. Nano-micelles based on hydroxyethyl starch-curcumin conjugates for improved stability, antioxidant and anticancer activity of curcumin

Author:: Shuting Chen; Jie Wu; Qiang Tang; Chenlan Xu; Yan Huang; Da Huang; Fang Luo; Yuanzi Wu; Fen Yan; Zuquan Weng; Shaoyun Wang
Source:: Carbohydrate polymers 2019 pp. -
ISSN:: 0144-8617
Subject:: antineoplastic activity; antioxidant activity; antioxidants; bioavailability; curcumin; drug formulations; drugs; functional foods; hydrophilicity; nanoparticles; neoplasms; solubility; starch; storage quality; temperature; toxicity testing; ultraviolet radiation
Abstract:: ... In this study, amphiphilic conjugates were synthesized by conjugating curcumin (CUR) to a food-derived hydrophilic hydroxyethyl starch (HES) via an acid-labile ester linker. The self-assembly of the conjugates formed uniform micellar nanoparticles (HES-CUR NPs) with a desirable drug loading efficiency, excellent colloidal and storage stability, as well as acid-responsive release manner. Besides, t ...
DOI:: 10.1016/j.carbpol.2019.115398
: https://doi.org/10.1016/j.carbpol.2019.115398

72. Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats

Author:: Kalaiselvi Sivalingam; Vinoth Amirthalingam; Karunagaran Ganasan; Chih-Yang Huang; Vijaya Padma Viswanadha
Source:: Food and chemical toxicology 2019 v.123 pp. 385-398
ISSN:: 0278-6915
Subject:: alkaloids; antineoplastic activity; antioxidant activity; antioxidants; carcinogenesis; caspase-3; caspase-9; diethylnitrosamine; gene expression; histopathology; laboratory animals; lipid peroxidation; lungs; oxidative stress; rats; transcription factor NF-kappa B; vascular endothelial growth factors
Abstract:: ... Neferine is a bisbenzylisoquinoline alkaloid isolated from the embryos of lotus which has attracted attention for its anti-inflammatory and anti-cancer activities. The aim of this study was to evaluate the anti-cancer effect of neferine against diethylnitrosamine (DEN)-induced lung carcinogenesis in Wistar rats and to explore the underlying molecular mechanism. DEN-induced oxidative stress is medi ...
DOI:: 10.1016/j.fct.2018.11.014
: https://doi.org/10.1016/j.fct.2018.11.014

73. On higher nutritional and medical properties of a carotenoid-rich mutant pomelo (Citrus maxima (L.) Osbeck)

Author:: Fang Wang; Jieru Lin; Lingling Xu; Qianqian Peng; Hangyin Huang; Linjia Tong; Qi Lu; Changchun Wang; Li Yang
Source:: Industrial crops and products 2019 v.127 pp. 142-147
ISSN:: 0926-6690
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Citrus maxima; antineoplastic activity; antioxidant activity; antioxidants; beta-carotene; clinical trials; color; fruit quality; fruits; juices; lycopene; mutants; neoplasm cells; pummelos; total soluble solids
Abstract:: ... Red-fleshed pomelo (Citrus maxima (L.) Osbeck), a spontaneous bud mutant of Guanxi pomelo, attracts consumers because of its distinct flesh color, but the nutritional and medical properties as compared with its parental Guanxi pomelo are not known. This study analyzed and evaluated the conventional fruit quality indexes, composition and content of carotenoids, antioxidant activities, bile-acid-bin ...
DOI:: 10.1016/j.indcrop.2018.10.065
: https://doi.org/10.1016/j.indcrop.2018.10.065

74. Optimization of polysaccharide extraction process from grifola frondosa and its antioxidant and anti-tumor research

Author:: Xiaoyu Chen; Haiyu Ji; Xiaomeng Xu; Anjun Liu
Source:: Journal of food measurement & characterization 2019 v.13 no.1 pp. 144-153
ISSN:: 2193-4126
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Grifola frondosa; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; human cell lines; microwave treatment; polysaccharides; raw materials; temperature; ultrasonics
Abstract:: ... In order to get high yield polysaccharide from grifola frondosa, single factor experiment and an orthogonal experiment were applied to optimize the best extraction conditions. Extraction time, extraction temperature, ratio of raw material to water and auxiliary factors (microwave assisted, ultrasound assisted) were the main factors to influence the yield and purity of the extracted crude polysacch ...
DOI:: 10.1007/s11694-018-9927-9
: https://doi.org/10.1007/s11694-018-9927-9

75. Optimized Extraction, Preliminary Characterization and Evaluation of the in Vitro Anticancer Activity of Phlorotannin-Rich Fraction from the Brown Seaweed, Cystoseira sedoides

Author:: Amal Abdelhamid; Sirine Lajili; Mohamed Amine Elkaibi; Yosra Ben Salem; Ameni Abdelhamid; Christian D. Muller; Hatem Majdoub; Jamil Kraiem; Abderrahman Bouraoui
Source:: Journal of aquatic food product technology 2019 v.28 no.9 pp. 892-909
ISSN:: 1547-0636
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Cystoseira; EDTA (chelating agent); Fourier transform infrared spectroscopy; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; benzaldehyde; bioactive compounds; breast neoplasms; dimethyl sulfoxide; ethanol; fetal bovine serum; high performance liquid chromatography; inhibitory concentration 50; microwave treatment; models; neoplasm cells; phosphates; propidium; response surface methodology
Abstract:: ... Brown seaweeds produce useful bioactive substances with high cosmetic and pharmacological values due to the presence of antioxidant derivatives, mainly phlorotannins (PHT), which are of particular interest. A central composite rotatable design (CCRD) with three variables (extraction time, dry material-to-solvent ratio and ethanol concentration) and two responses was performed to optimize the micro ...
DOI:: 10.1080/10498850.2019.1662865
: https://doi.org/10.1080/10498850.2019.1662865

76. Pharmacological Properties of Morus nigra L. (Black Mulberry) as A Promising Nutraceutical Resource

Author:: Sung Ho Lim; Chang-Ik Choi
Source:: Nutrients 2019 v.11 no.2 pp. -
ISSN:: 2072-6643
Subject:: Morus nigra; antineoplastic activity; antioxidant activity; chronic diseases; cosmetics; dietary supplements; fruit juices; herbal medicines; jams; marmalades; protective effect; raw materials; silkworms; therapeutics; vinegars; wines; Asia
Abstract:: ... Mulberry plants belonging to the Moraceae family have been grown for the purpose of being the nutrient source for silk worm and raw materials for the preparation of jams, marmalades, vinegars, juices, wines, and cosmetics. Morus nigra L. (black mulberry) is native to Southwestern Asia, and it has been used as a traditional herbal medicine for animals and humans. In this article, recent research pr ...
DOI:: 10.3390/nu11020437
PubMed:: 30791521
PubMed Central:: PMC6412198
: https://doi.org/10.3390/nu11020437

77. Phenolic Profiles and Antioxidant Activities of 30 Tea Infusions from Green, Black, Oolong, White, Yellow and Dark Teas

Author:: Cai-Ning Zhao; Guo-Yi Tang; Shi-Yu Cao; Xiao-Yu Xu; Ren-You Gan; Qing Liu; Qian-Qian Mao; Ao Shang; Hua-Bin Li
Source:: Antioxidants 2019 v.8 no.7 pp. -
ISSN:: 2076-3921
Subject:: antineoplastic activity; antioxidant activity; caffeine; cardioprotective effect; flavanols; gallic acid; green tea; iron; polyphenols; tea (beverage)
Abstract:: ... Tea is among the most consumed drink worldwide, and its strong antioxidant activity is considered as the main contributor to several health benefits, such as cardiovascular protection and anticancer effect. In this study, the antioxidant activities of 30 tea infusions, which were obtained by the mimic of drinking tea of the public, from green, black, oolong, white, yellow and dark teas, were evalu ...
DOI:: 10.3390/antiox8070215
PubMed:: 31295859
PubMed Central:: PMC6680489
: https://doi.org/10.3390/antiox8070215

78. Phenolics, tannins, flavonoids and anthocyanins contents influenced antioxidant and anticancer activities of Rubus fruits from Western Ghats, India

Author:: Kasipandi Muniyandi; Elizabeth George; Saikumar Sathyanarayanan; Blassan P. George; Heidi Abrahamse; Suman Thamburaj; Parimelazhagan Thangaraj
Source:: Food science and human wellness 2019 v.8 no.1 pp. 73-81
ISSN:: 2213-4530
Subject:: Rubus niveus; anthocyanins; antineoplastic activity; antioxidant activity; antioxidants; cytotoxicity; dietary supplements; ethyl acetate; free radicals; fruits; functional foods; methanol; regression analysis; tannins; India
Abstract:: ... Rubus fruits are rich in nutrition with a wide range of phytochemical and consumed by humans, but many of its wild varieties are not commercially useful. Phytochemical exploration of these wild fruits could improve the commercial usage of these Rubus species.This study focuses to analyze the phytochemical, antioxidant and cytotoxicity of three wild Rubus ellipticus, R. niveus and R. fairholmianus ...
DOI:: 10.1016/j.fshw.2019.03.005
: https://doi.org/10.1016/j.fshw.2019.03.005

79. Phytochemical and Health‐Beneficial Progress of Turnip (Brassica rapa)

Author:: Swastika Paul; Chang‐An Geng; Tong‐Hua Yang; Yong‐Ping Yang; Ji‐Jun Chen
Source:: Journal of food science 2019 v.84 no.1 pp. 19-30
ISSN:: 0022-1147
Subject:: Brassica rapa; active ingredients; antineoplastic activity; antioxidant activity; chest; drugs; flavonoids; free radical scavengers; glucosinolates; headache; indoles; isothiocyanates; neoplasms; oils; phenolic compounds; protective effect; rabies; traditional medicine; turnips
Abstract:: ... Despite the advancement of medical science, diseases are part‐and‐parcel of human life. Plants have provided humans with medicines since time immemorial, and are still one of the primary sources for drug discovery. Brassica rapa L., commonly known as turnip, is one of the world's oldest cultivated vegetables. Besides being an important vegetable and source of oil, turnip is also used as a traditio ...
DOI:: 10.1111/1750-3841.14417
: https://doi.org/10.1111/1750-3841.14417

80. Phytochemical and pharmacological evaluation of methanolic extracts of Etlingera fimbriobracteata (Zingerberaceae)

Author:: A.F.M. Shahid-Ud-Daula; M.A.A. Kuyah; A.S. Kamariah; L.B.L. Lim; N. Ahmad
Source:: South African journal of botany 2019 v.121 pp. 45-53
ISSN:: 0254-6299
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Etlingera; Gram-negative bacteria; Gram-positive bacteria; antineoplastic activity; antioxidant activity; antioxidants; blood glucose; cardiac glycosides; chemical constituents of plants; cooking; cosmetics; free radicals; fungi; herbs; human cell lines; humans; inhibitory concentration 50; laboratory animals; leaf extracts; leaves; neoplasm cells; polyphenols; rats; rhizomes; saponins; screening; steroids; uterine cervical neoplasms; Borneo
Abstract:: ... Etlingera species are widely used traditionally as cooking herbs for their medicinal properties and also used as cosmetics by different ethnic communities in Borneo. This study investigated the bioactive potential of methanolic extracts of leaves, stems and rhizomes of Etlingera fimbriobracteata. Standard methods were applied to detect the presence of phytochemicals and to determine the phenolic c ...
DOI:: 10.1016/j.sajb.2018.10.013
: https://doi.org/10.1016/j.sajb.2018.10.013

81. Phytochemical profiling, antioxidant and anticancer activities of Gastrocotyle hispida growing in Saudi Arabia

Author:: Abdelaaty A. Shahat; Syed Hidayathulla; Azmat A. Khan; Amer M. Alanazi; Osaid T. Al Meanazel; Ali S. Alqahtani; Mansour S. Alsaid; Ahmed A. Hussein
Source:: Acta tropica 2019 v.191 pp. 243-247
ISSN:: 0001-706X
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Boraginaceae; aerial parts; antineoplastic activity; antineoplastic agents; antioxidant activity; beta-sitosterol; breast neoplasms; breasts; cell lines; chromatography; dose response; free radical scavengers; gallic acid; in vitro studies; inhibitory concentration 50; kidneys; leaves; liver; methanol; models; neoplasm cells; polyphenols; quercetin; rheumatoid arthritis; rosmarinic acid; tea; Saudi Arabia
Abstract:: ... The present study aimed at isolation the phytocompounds from the aerial parts of Gastrocotyle hispida and to evaluate its antioxidant and anticancer potential using in vitro assay. Gastrocotyle hispida is belonging to the family Boraginaceae used as a refreshing drink like tea. The decoction of the leaves is diuretic and is used in the treatment of rheumatism. Phytochemical study of a methanol ext ...
DOI:: 10.1016/j.actatropica.2019.01.013
: https://doi.org/10.1016/j.actatropica.2019.01.013

82. Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Callistemon citrinus Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell Lines

Author:: Rashid Ahmed; Muhammad Tariq; Irfan S. Ahmad; Hanafy Fouly; Fakhar-i-Abbas; Anwarul Hasan; Mosbah Kushad
Source:: Journal of food quality 2019 v.2019 pp. -
ISSN:: 0146-9428
Subject:: Callistemon citrinus; absorption; antineoplastic activity; antioxidant activity; berberine; breast neoplasms; cell lines; diet; drugs; encapsulation; fruits; gastrointestinal system; growth retardation; human health; nanocapsules; nanoparticles; neoplasm cells; phenolic compounds; risk reduction; solubility; therapeutics; vegetables
Abstract:: ... Fruit and vegetable diets rich in phenolic compounds reduce the risk of various cancers and offer multiple other health benefits due to their bioactivity and powerful antioxidant properties. However, the human health benefits of most phenolic compounds are restricted due to their limited aqueous solubility, low absorption, restricted passive cellular efflux, and poor gastrointestinal stability. Na ...
DOI:: 10.1155/2019/2638481
: https://doi.org/10.1155/2019/2638481

83. Polyphenol Profile and Pharmaceutical Potential of Quercus spp. Bark Extracts

Author:: Hosam O. Elansary; Agnieszka Szopa; Paweł Kubica; Halina Ekiert; Mohamed A. Mattar; Mohamed A. Al-Yafrasi; Diaa O. El-Ansary; Tarek K. Zin El-Abedin; Kowiyou Yessoufou
Source:: Plants 2019 v.8 no.11 pp. -
ISSN:: 2223-7747
Subject:: Aspergillus flavus; Escherichia coli; Micrococcus; Penicillium; Pseudomonas aeruginosa; Quercus acutissima; Quercus macrocarpa; Quercus robur; Talaromyces funiculosus; antibacterial properties; antifungal properties; antineoplastic activity; antioxidant activity; bacteria; bark; bark extracts; caffeic acid; disease control; ellagic acid; free radical scavengers; fungi; high performance liquid chromatography; human cell lines; neoplasm cells; neoplasms; polyphenols; trees
Abstract:: ... Targeted profiling of polyphenols in trees may reveal valuable sources of natural compounds with major applications in pharmacology and disease control. The current study targeted the profiling of polyphenols using HPLC-DAD in Quercus robur, Q. macrocarpa and Q. acutissima bark extracts. Free radical scavenging of each extract was investigated using antioxidant assays. Antimicrobial activities aga ...
DOI:: 10.3390/plants8110486
PubMed:: 31717611
PubMed Central:: PMC6918147
: https://doi.org/10.3390/plants8110486

84. Polyphenolic extracts of walnut (Juglans regia) green husk containing juglone inhibit the growth of HL-60 cells and induce apoptosis

Author:: Carmen Soto-Maldonado; Mauricio Vergara-Castro; John Jara-Quezada; Eduardo Caballero-Valdés; Andrea Müller-Pavez; María Elvira Zúñiga-Hansen; Claudia Altamirano
Source:: Electronic Journal of Biotechnology 2019 v.39 pp. 1-7
ISSN:: 0717-3458
Subject:: Juglans regia; antineoplastic activity; antioxidant activity; apoptosis; biotechnology; carcinogenicity; cell culture; dose response; fibroblasts; hulls; juglone; membrane potential; mitochondrial membrane; protective effect; synthesis; viability; walnuts
Abstract:: ... Juglone is a naphthoquinone currently obtained by chemical synthesis with biological activities including antitumor activity. Additionally, juglone is present in the green husk of walnut, which suggests evaluating the effect of GH extracts on carcinogenic cell lines.Walnut green husk ethanolic extract was obtained as 169.1 mg juglone/100 g Green Husk and antioxidant activity (ORAC) of 44,920 μmol ...
DOI:: 10.1016/j.ejbt.2019.02.001
: https://doi.org/10.1016/j.ejbt.2019.02.001

85. Production and characterization of exopolysaccharides from Chlorella zofingiensis and Chlorella vulgaris with anti-colorectal cancer activity

Author:: Jianzhi Zhang; Lu Liu; Feng Chen
Source:: International journal of biological macromolecules 2019 v.134 pp. 976-983
ISSN:: 0141-8130
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Chlorella vulgaris; antineoplastic activity; antineoplastic agents; antioxidant activity; cell viability; colorectal neoplasms; exopolysaccharides; human cell lines; humans; hydroxyl radicals; microalgae; molecular weight; neoplasm cells; sugars
Abstract:: ... The production, physicochemical characteristics, antioxidant and antitumor activities of partial purified exopolysaccharides from Chlorella zofingiensis, Chlorella vulgaris were investigated. The final exopolysaccharides productions were 208.4, 364.3 mg/L and the average molecular weights were 2.66×104, 1.88×104 Da, respectively. Monosaccharide analysis indicating that these exopolysaccharides con ...
DOI:: 10.1016/j.ijbiomac.2019.05.117
: https://doi.org/10.1016/j.ijbiomac.2019.05.117

86. Protective effects of kefir against deltamethrin-induced hepatotoxicity in rats

Author:: Emna El Golli-Bennour; Rim Timoumi; Emna Annaibi; Moncef Mokni; Asma Omezzine; Hassen Bacha; Salwa Abid-Essefi
Source:: Environmental science and pollution research international 2019 v.26 no.18 pp. 18856-18865
ISSN:: 0944-1344
Subject:: DNA damage; acaricides; alanine transaminase; albino; antineoplastic activity; antioxidant activity; antioxidants; aspartate transaminase; bacteria; bilirubin; blood chemistry; blood serum; catalase; cholesterol; hepatotoxicity; histology; humans; immune system; inflammation; ingestion; insects; kefir; males; malondialdehyde; protective effect; pyrethrins; rats; superoxide dismutase; water pollution
Abstract:: ... Deltamethrine (DLM) is a synthetic pyrethroid with broad spectrum activities against acaricides and insects. Widely used for agricultural and veterinary purposes, its human and animal exposure occurs by ingestion of contaminated water and food and leads to serious health problems. Kefir is fermented milk with numerous health favors counting restorative properties of bacterial flora, immune system ...
DOI:: 10.1007/s11356-019-05253-4
: https://doi.org/10.1007/s11356-019-05253-4

87. Protective effects of kefir against zearalenone toxicity mediated by oxidative stress in cultured HCT-116 cells

Author:: Emna El Golli-Bennour; Rim Timoumi; Meriam Koroit; Hassen Bacha; Salwa Abid-Essefi
Source:: Toxicon 2019 v.157 pp. 25-34
ISSN:: 0041-0101
Subject:: Fusarium; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; bacteria; beverages; catalase; cell proliferation; cholesterol; colorectal neoplasms; feeds; fluorescence; free radicals; heat shock proteins; humans; immune system; ingestion; kefir; lactose intolerance; malondialdehyde; membrane potential; mitochondrial membrane; neoplasm cells; oxidative stress; protective effect; protein synthesis; small cereal grains; superoxide dismutase; toxicity; zearalenone
Abstract:: ... Kefir is a fermented milk with numerous health favors counting restorative properties of bacterial flora, reduction of the symptoms of lactose intolerance, immune system stimulation, cholesterol reduction, as well as anti-mutagenic and anti-tumor properties. Zearalenone (ZEN) is a mycotoxin produced by some Fusarium species. ZEN often occurs as a contaminant in cereal grains and animal feeds. Huma ...
DOI:: 10.1016/j.toxicon.2018.11.296
: https://doi.org/10.1016/j.toxicon.2018.11.296

88. Purification, characterization and utilization of polysaccharide of Araucaria heterophylla gum for the synthesis of curcumin loaded nanocarrier

Author:: Antony V. Samrot; J. Lavanya Agnes Angalene; S.M. Roshini; S.M. Stefi; R. Preethi; P. Raji; A. Madan Kumar; Ponnaiah Paulraj; S. Suresh Kumar
Source:: International journal of biological macromolecules 2019 v.140 pp. 393-400
ISSN:: 0141-8130
Subject:: Araucaria heterophylla; Fourier transform infrared spectroscopy; allose; antibacterial properties; antineoplastic activity; antioxidant activity; antioxidants; arabinose; atomic force microscopy; breast neoplasms; curcumin; cytotoxicity; drugs; energy-dispersive X-ray analysis; galactose; gas chromatography-mass spectrometry; glucosinolates; human cell lines; humans; nanocarriers; neoplasm cells; phenol; phosphates; polysaccharides; rhamnose; scanning electron microscopy; solvents; sulfuric acid; thermogravimetry; ultraviolet-visible spectroscopy
Abstract:: ... In this study, gum of Araucaria heterophylla was collected. The collected gum was subjected for extraction of polysaccharide using solvent extraction system. Thus, extracted polysaccharide was further purified using solvent method and was characterized using UV–Vis spectroscopy, Phenol sulfuric acid assay, FTIR, TGA, TLC and GC–MS. The gum derived polysaccharide was found to have the following sug ...
DOI:: 10.1016/j.ijbiomac.2019.08.121
: https://doi.org/10.1016/j.ijbiomac.2019.08.121

89. Rapid biosynthesis and characterization of silver nanoparticles from the leaf extract of Tropaeolum majus L. and its enhanced in-vitro antibacterial, antifungal, antioxidant and anticancer properties

Author:: Saritha Valsalam; Paul Agastian; Mariadhas Valan Arasu; Naif Abdullah Al-Dhabi; Abdul-Kareem Mohammed Ghilan; K. Kaviyarasu; Balasubramani Ravindran; Soon Woong Chang; S. Arokiyaraj
Source:: Journal of photochemistry and photobiology 2019 v.191 pp. 65-74
ISSN:: 1011-1344
Subject:: Fourier transform infrared spectroscopy; Pseudomonas aeruginosa; Tropaeolum majus; X-ray diffraction; antifungal properties; antineoplastic activity; antioxidant activity; bacteria; biosynthesis; cell lines; chemical constituents of plants; crystal structure; doxorubicin; ethanol; gas chromatography-mass spectrometry; infectious diseases; inhibitory concentration 50; ions; leaf extracts; medicinal plants; nanocrystals; nanoparticles; nanosilver; phenylacetic acid; reducing agents; scanning electron microscopy; silver; spectral analysis; therapeutics
Abstract:: ... Eco-friendly biosynthesis of nanoparticles from medicinal plants as reducing agent has gained importance due to its potential therapeutic uses. In the present study Silver nanoparticles (AgNPs) were eco-friendly synthesized using the leaf extracts of the medicinal plant Tropaeolum majus. The obtained AgNPs were characterized by UV - visible spectrum, FTIR, SEM and XRD which clearly showed the redu ...
DOI:: 10.1016/j.jphotobiol.2018.12.010
: https://doi.org/10.1016/j.jphotobiol.2018.12.010

90. Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms

Author:: Dorota Skrajnowska; Barbara Bobrowska-Korczak
Source:: Nutrients 2019 v.11 no.10 pp. -
ISSN:: 2072-6643
Subject:: DNA; RNA; antineoplastic activity; antioxidant activity; cell communication; cell differentiation; cell structures; defense mechanisms; diet; enzyme activation; epidemiological studies; humans; immune system; neoplasms; nutrient deficiencies; nutrition risk assessment; transcription factors; zinc
Abstract:: ... The human body cannot store zinc reserves, so a deficiency can arise relatively quickly, e.g., through an improper diet. Severe zinc deficiency is rare, but mild deficiencies are common around the world. Many epidemiological studies have shown a relationship between the zinc content in the diet and the risk of cancer. The anti-cancer effect of zinc is most often associated with its antioxidant pro ...
DOI:: 10.3390/nu11102273
PubMed:: 31546724
PubMed Central:: PMC6835436
: https://doi.org/10.3390/nu11102273

91. Role of flavonoids in plant interactions with the environment and against human pathogens — A review

Author:: Muhammad Khalid; Saeed-ur-Rahman; Muhammad Bilal; Dan-feng HUANG
Source:: Journal of integrative agriculture 2019 v.18 no.1 pp. 211-230
ISSN:: 2095-3119
Subject:: animal pathogens; antineoplastic activity; antioxidant activity; atherosclerosis; cell differentiation; environmental factors; flavonoids; free radicals; human health; humans; neoplasms; plant protection; polyphenols; secondary metabolites
Abstract:: ... Flavonoids are widely-distributed polyphenolic secondary metabolites with diverse biological activities in plants and benefit human health as protective dietary agents. They participate in plants' responses to harsh environmental conditions and effectively regulate the cell differentiation and growth. In plants, the majority of their functions are attributed to their strong antioxidative propertie ...
DOI:: 10.1016/S2095-3119(19)62555-4
: https://doi.org/10.1016/S2095-3119(19)62555-4

92. Spruce and beech bark aqueous extracts: source of polyphenols, tannins and antioxidants correlated to in vitro antitumor potential on two different cell lines

Author:: Sanda-Liliana Coșarcă; Elena-Alina Moacă; Corneliu Tanase; Daniela Lucia Muntean; Ioana Zinuca Pavel; Cristina Adriana Dehelean
Source:: Wood science and technology 2019 v.53 no.2 pp. 313-333
ISSN:: 0043-7719
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Fagus sylvatica; Picea abies; antineoplastic activity; antioxidant activity; antioxidants; bark; cell lines; cell proliferation; cytotoxicity; dose response; humans; keratinocytes; lung neoplasms; melanoma; metastasis; neoplasm cells; plant extracts; polyphenols; tannins; ultrasonic treatment
Abstract:: ... The purpose of the present study was to determine the antioxidant capacity, the total phenol content, tannins, the cytotoxic and antiproliferative activity of some aqueous extracts obtained from spruce bark (Picea abies L.) and beech bark (Fagus sylvatica L.). In this regard, two types of extracts were obtained from both species using different methods of extraction: classical water bath extractio ...
DOI:: 10.1007/s00226-018-1071-5
: https://doi.org/10.1007/s00226-018-1071-5

93. Stem extract of Tabebuia chrysantha induces apoptosis by targeting sEGFR in Ehrlich Ascites Carcinoma

Author:: Siva Prasad Panda; Uttam Prasad Panigrahy; Subhranshu Panda; Bikash R. Jena
Source:: Journal of ethnopharmacology 2019 v.235 pp. 219-226
ISSN:: 0378-8741
Subject:: Artemia; Handroanthus chrysanthus subsp. chrysanthus; Western blotting; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; ascites; carcinoma; catalase; cell viability; cytotoxicity; death; dose response; epidermal growth factor receptors; fluorouracil; glutathione; hematologic tests; high performance liquid chromatography; laboratory animals; lipid peroxidation; methanol; mice; neoplasm cells; nuclear magnetic resonance spectroscopy; polyphenols; quinones; stems; superoxide dismutase; toxicity testing; traditional medicine; ultraviolet-visible spectroscopy; Central America; India
Abstract:: ... The plant Tabebuia chrysantha (Jaq.) Nicholson (Bignoniaceae) is commonly known as “Golden Goddess” in the Southern part of India and “Golden Trumpet Tree “ in Central America. Stems of this plant have been traditionally used for antioxidant, anti-inflammatory, antimicrobial and anticancer actions.To evaluate the antitumor activity of methanol extract of Tabebuia chrysantha stem (METC).The in vivo ...
DOI:: 10.1016/j.jep.2019.02.023
: https://doi.org/10.1016/j.jep.2019.02.023

94. Structure characterization and antioxidant activity of fucoidan isolated from Undaria pinnatifida grown in New Zealand

Author:: Hui Si Audrey Koh; Jun Lu; Weibiao Zhou
Source:: Carbohydrate polymers 2019 v.212 pp. 178-185
ISSN:: 0144-8617
Subject:: Fourier transform infrared spectroscopy; Undaria pinnatifida; antineoplastic activity; antioxidant activity; butylated hydroxyanisole; chemical composition; fucoidan; glycosidic linkages; molecular weight; sulfates; New Zealand
Abstract:: ... Fucoidan from brown seaweed species, Undaria pinnatifida, has numerous bioactive properties such as antioxidant and anticancer activities. The objective of this research was to quantify the chemical composition of fucoidan isolated from U. pinnatifida harvested in New Zealand and to determine its molecular structure and antioxidant capacity. Crude fucoidan (Fcrude) and purified fucoidan with molec ...
DOI:: 10.1016/j.carbpol.2019.02.040
: https://doi.org/10.1016/j.carbpol.2019.02.040

95. Synergistic antioxidant activity and anticancer effect of green tea catechin stabilized on nanoscale cyclodextrin-based metal–organic frameworks

Author:: Fei Ke; Mengran Zhang; Nianqiao Qin; Gege Zhao; Jun Chu; Xiaochun Wan
Source:: Journal of materials science 2019 v.54 no.14 pp. 10420-10429
ISSN:: 0022-2461
Subject:: antineoplastic activity; antioxidant activity; catechin; cell growth; cell viability; coordination polymers; encapsulation; epigallocatechin gallate; green tea; models; neoplasm cells; neoplasms; porous media; vapors; viability assays
Abstract:: ... Green tea catechins have received significant attention due to their potent antioxidant activity as well as diverse biological properties. Stabilizing and protecting catechins from degradation is very important but challenging. In this work, a nanosized edible γ-cyclodextrin-based metal–organic framework (CD-MOF) was designed and fabricated by a facile vapor diffusion route and applied for the enc ...
DOI:: 10.1007/s10853-019-03604-7
: https://doi.org/10.1007/s10853-019-03604-7

96. Synthesis and biological evaluation of quercetin and resveratrol peptidyl derivatives as potential anticancer and antioxidant agents

Author:: Ljiljana Mrkus; Jelena Batinić; Nina Bjeliš; Andreja Jakas
Source:: Amino acids 2019 v.51 no.2 pp. 319-329
ISSN:: 0939-4451
Subject:: antineoplastic activity; antioxidant activity; antioxidants; esters; fruits; models; monitoring; peptides; polyphenols; quercetin; resveratrol; tea; vegetables; wines
Abstract:: ... Quercetin and resveratrol are polyphenolic compounds, members of the flavonoid and the stilbene family, respectively, both medicinally important as dietary anticancer and antioxidant agents. They are present in a variety of foods—including fruits, vegetables, tea, wine, as well as other dietary supplements—and are responsible for various health benefits. Different quercetin and resveratrol esters ...
DOI:: 10.1007/s00726-018-2668-6
: https://doi.org/10.1007/s00726-018-2668-6

97. Synthesis of Lipophilic Esters of Tyrosol, Homovanillyl Alcohol and Hydroxytyrosol

Author:: Roberta Bernini; Isabella Carastro; Francesca Santoni; Mariangela Clemente
Source:: Antioxidants 2019 v.8 no.6 pp. -
ISSN:: 2076-3921
Subject:: Olea europaea; ambient temperature; antineoplastic activity; antioxidant activity; byproducts; carbonates; cosmetics; dietary supplements; esters; foods; green chemistry; hydrophilicity; lipids; lipophilicity; organochlorine compounds; phenols; solubility; solubilization; solvents; stabilizers
Abstract:: ... Low-molecular weight phenols such as tyrosol, homovanillyl alcohol and hydroxytyrosol are valuable compounds that exhibit a high number of health-promoting effects such as antioxidant, anti-inflammatory and anticancer activity. Despite these remarkable properties, their applications such as dietary supplements and stabilizers of foods and cosmetics in non-aqueous media are limited for the hydrophi ...
DOI:: 10.3390/antiox8060174
PubMed:: 31197081
PubMed Central:: PMC6617409
: https://doi.org/10.3390/antiox8060174

98. Targeted delivery of phycocyanin for the prevention of colon cancer using electrospun fibers

Author:: Peng WenThese authors have contributed equally and are co-first authors.; Teng-Gen Hu; Yan Wen; Robert J. Linhardt; Min-Hua Zong; Yu-Xiao Zou; Hong Wu
Source:: Food & function 2019 v.10 no.4 pp. 1816-1825
ISSN:: 2042-650X
Subject:: antineoplastic activity; antioxidant activity; apoptosis; bioavailability; caspase-3; cell growth; colon; colorectal neoplasms; dose response; encapsulation; functional foods; interphase; phycocyanin; water solubility
Abstract:: ... Phycocyanin (PC), a water-soluble biliprotein, exhibits potent anti-colon cancer properties. However, its application in functional foods is limited by the poor stability and low bioavailability of PC. In this study, we successfully encapsulated PC by coaxial electrospinning. The colon targeted release of PC was achieved with retention of the antioxidant activity of PC. The PC-loaded electrospun f ...
DOI:: 10.1039/c8fo02447b
: https://doi.org/10.1039/c8fo02447b

99. The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines

Author:: Paola Ghanem; Annalise Zouein; Maya Mohamad; Mohammad H. Hodroj; Tony Haykal; Sonia Abou Najem; Hassan Y. Naim; Sandra Rizk
Source:: Nutrients 2019 v.11 no.11 pp. -
ISSN:: 2072-6643
Subject:: DNA fragmentation; antineoplastic activity; antioxidant activity; apoptosis; blood; cell cycle; cell lines; dose response; gamma-tocotrienol; myeloid leukemia; neoplasm cells; proteins; reactive oxygen species; therapeutics; tocopherols; viability
Abstract:: ... Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, including tocopherols were considered as potential anti-tumor compounds. Recently, other isoforms of vitam ...
DOI:: 10.3390/nu11112808
PubMed:: 31744219
PubMed Central:: PMC6893610
: https://doi.org/10.3390/nu11112808

100. The effects of Pueraria mirifica extract, diadzein and genistein in testosterone-induced prostate hyperplasia in male Sprague Dawley rats

Author:: Jamaludin Mohamad; Siti Saleha Masrudin; Zazali Alias; Nur Airina Muhamad
Source:: Molecular biology reports 2019 v.46 no.2 pp. 1855-1871
ISSN:: 0301-4851
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Pueraria; alanine transaminase; albumins; alkaline phosphatase; antineoplastic activity; antioxidant activity; aspartate transaminase; bilirubin; body weight; follicle-stimulating hormone; genistein; globulins; high density lipoprotein; homeostasis; hyperplasia; interleukin-6; kidneys; laboratory animals; liver; luteinizing hormone; males; medicinal plants; oral administration; plant estrogens; protein content; rats; testes; testosterone; toxicity; triacylglycerols; zinc; Thailand
Abstract:: ... Pueraria mirifica (PM) is a medicinal plant native to Thailand contained high amount of phytoestrogen and possesses anticancer activity. This study reports the effect of P. mirifica extract, phytoestrogen of diadzein and genistein for its benign prostate hyperplasia properties in testosterone-induced prostate hyperplasia in male Sprague Dawley rats. The P. mirifica extract was evaluated for its to ...
DOI:: 10.1007/s11033-019-04638-5
: https://doi.org/10.1007/s11033-019-04638-5

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1. A review on applications of chitosan-based Schiff bases

2. A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications

3. Allium vegetables for possible future of cancer treatment

4. An update on the mechanisms related to cell death and toxicity of doxorubicin and the protective role of nutrients

5. Anchusa azurea Mill. (Boraginaceae) aerial parts methanol extract interfering with cytoskeleton organization induces programmed cancer cells death

6. Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin

7. Anti-Aging Effect of Agar Oligosaccharide on Male Drosophila melanogaster and Its Preliminary Mechanism

8. Anti-inflammatory effect of Vaccinium oldhamii stems through inhibition of NF-κB and MAPK/ATF2 signaling activation in LPS-stimulated RAW264.7 cells

9. Anti-proliferative, pro-apoptotic and anti-oxidative activity of Lactobacillus and Bifidobacterium strains: A review of mechanisms and therapeutic perspectives

10. Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk

11. Anticancer, antimicrobial, antioxidant, and catalytic activities of green-synthesized silver and gold nanoparticles using Bauhinia purpurea leaf extract

12. Antihepatocarcinogenic activity of whey protein concentrate and lactoferrin in diethylnitrosamine‐treated male albino mice

13. Antioxidant Capacity and Cytotoxic Effects of Catechins and Resveratrol Oligomers Produced by Enzymatic Oxidation against T24 Human Urinary Bladder Cancer Cells

14. Antioxidant activities of α-lipoic acid free and nano-capsule inhibit the growth of Ehrlich carcinoma

15. Antioxidant and anticancer effects in human hepatocarcinoma (HepG2) cells of papain-hydrolyzed sorghum kafirin hydrolysates

16. Antioxidant and immunomodulatory activity induced by stevioside in liver damage: In vivo, in vitro and in silico assays

17. Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes

18. Antioxidant, cytotoxicity and anti-tumor activity of Cordia dichotoma fruits accompanied with its volatile and sugar composition

19. Antioxidative, Anti-Inflammatory, and Anticancer Effects of Purified Flavonol Glycosides and Aglycones in Green Tea

20. Antitumor activity of Cuphea ignea extract against benzo(a)pyrene-induced lung tumorigenesis in Swiss Albino mice

21. Antitumor and antioxidant effects of Clinacanthus nutans Lindau in 4 T1 tumor-bearing mice

22. Assessing Anticancer Potential of Blueberry Flavonoids, Quercetin, Kaempferol, and Gentisic Acid, Through Oxidative Stress and Apoptosis Parameters on HCT-116 Cells

23. Assessment of the cytotoxicity, antioxidant activity and chemical composition of extracts from the cyanobacterium Fischerella major Gomont

24. Betulinic Acid, the first lupane-type triterpenoid isolated via bioactivity-guided fractionation, and identified by spectroscopic analysis from leaves of Nyctanthes arbor-tristis: its potential biological activities in vitro assays

25. Bioactive peptide with antioxidant and anticancer activities from black soybean [Glycine max (L.) Merr.] byproduct: isolation, identification and molecular docking study

26. Capillary electrophoresis, high‐performance liquid chromatography, and thin‐layer chromatography analyses of phenolic compounds from rapeseed plants and evaluation of their antioxidant activity

27. Changes Over the Fermentation Period in Phenolic Compounds and Antioxidant and Anticancer Activities of Blueberries Fermented by Lactobacillus plantarum

28. Characterization, antioxidant, and anticancer activities of a neutral polysaccharide from Duchesnea indica (Andr.) Focke

29. Characterization, the Antioxidant and Antimicrobial Activity of Exopolysaccharide Isolated from Poultry Origin Lactobacilli

30. Chemical composition and bioactivity of essential oils and Ethanolic extracts of Ocimum basilicum L. and Thymus algeriensis Boiss. & Reut. from the Algerian Saharan Atlas

31. Chemical composition and biological activities of essential oil isolated by HS-SPME and UAHD from fruits of bergamot

32. Chemical composition and in vitro bioactivity of essential oil obtained from the flavedo of ‘Pompia’, an ancient Sardinian fruit

33. Chemical composition, antioxidant activity and antitumor activity of tumorous stem mustard leaf and stem extracts

34. Chemical structure and biological properties of a polysaccharide isolated from Pleurotus sajor-caju

35. Combined Nutraceuticals: A Novel Approach to Colitis-Associated Colorectal Cancer?

36. Comparison of the Effect of Native 1,4-Naphthoquinones Plumbagin, Menadione, and Lawsone on Viability, Redox Status, and Mitochondrial Functions of C6 Glioblastoma Cells

37. Composition, antioxidant capacity and cytotoxic activity of Eugenia uniflora L. chemotype-oils from the Amazon

38. Comprehensive review of antimicrobial activities of plant flavonoids

39. Construction of doxorubicin-conjugated lentinan nanoparticles for enhancing the cytotoxocity effects against breast cancer cells

40. Could volatile compounds from leaves and fruits of Pistacia lentiscus constitute a novel source of anticancer, antioxidant, antiparasitic and antibacterial drugs?

41. Cytogenotoxic effect, phytochemical screening and antioxidant potential of Jatropha mollissima (Pohl) Baill leaves

42. Cytotoxic and cell cycle arrest induction of pentacyclic triterpenoides separated from Lantana camara leaves against MCF-7 cell line in vitro

43. Determination of phenolic compounds, antioxidant and anticancer activity of Chrozophora tinctoria accessions collected from different regions of Iran

44. Development of Ganoderma lucidum spore powder based proteoglycan and its application in hyperglycemic, antitumor and antioxidant function

45. Dietary zerumbone from shampoo ginger: new insights into its antioxidant and anticancer activity

46. ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress

47. Effects of domestic cooking process on the chemical and biological properties of dietary phytochemicals

48. Ellagic acid ameliorates cisplatin induced hepatotoxicity in colon carcinogenesis

49. Engineered Polymeric Micelles for Combinational Oxidation Anticancer Therapy through Concurrent HO-1 Inhibition and ROS Generation

50. Enzymatic treatment improves the antioxidant and antiproliferative activities of Adenanthera pavonina L. seeds

51. Essential Oil Composition and Biological Activities of Aegle marmelos (L.) Correa Grown in Western Ghats Region-South India

52. Evaluation of antibacterial and anticancer properties of poly(3-hydroxybutyrate) functionalized with different amino compounds

53. Exopolysaccharides from the fungal endophytic Fusarium sp. A14 isolated from Fritillaria unibracteata Hsiao et KC Hsia and their antioxidant and antiproliferation effects

54. Exploitation of apple pomace towards extraction of triterpenic acids, antioxidant potential, cytotoxic effects, and inhibition of clinically important enzymes

55. Extracts of Hypsizygus tessellatus (white var.) caps inhibited MCF-7 and MDA-MB-231 cell lines proliferation

56. Gas chromatography-mass spectrometry analysis and antimicrobial, antioxidant and anti-cancer activities of essential oils and extracts of Stachys schtschegleevii plant as biological macromolecules

57. Glucosinolates metabolism and redox state of rocket (Eruca sativa Mill.) during germination

58. Green Tea Extract (Camellia sinensis) as a Potential Antitumoral Agent on Breast Cancer Cells (FS13-04-19)

59. Green synthesis of silver nanoparticles at low temperature in a fast pace with unique DPPH radical scavenging and selective cytotoxicity against MCF-7 and BT-20 tumor cell lines

60. Immunomodulatory and Antioxidant Activities of Sulfated Polysaccharides from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum

61. Impact of fermentation conditions on the production of bioactive compounds with anticancer, anti-inflammatory and antioxidant properties in kombucha tea extracts

62. Improved antioxidant, antimicrobial and anticancer activity of naringenin on conjugation with pectin

63. In Vitro Analysis of Antioxidant, Anticancer, and Bioactive Components of Apocynum venetum Tea Extracts

64. In vitro antioxidant, antidiabetic, antiacetylcholine esterase, anticancer activities and RP-HPLC analysis of phenolics from the wild bottle gourd (Lagenaria siceraria (Molina) Standl.)

65. In vitro cytotoxicity, antioxidant and anti-inflammatory activities of Pittosporum viridiflorum Sims and Hypoxis colchicifolia Baker used traditionally against cancer in Eastern Cape, South Africa

66. Inhibition of advanced glycation end products formation and inflammation in C. elegans: Studies of potential of Lyngbya sp. against expression of stress related genes and Live cell imaging

67. Inhibition of human breast cancer cells (MCF-7 cell line) growth via cell proliferation, migration, and angiogenesis by auraptene of Ferula szowitsiana root extract

68. Isoorientin improves scopolamine-induced cognitive impairments by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling in the hippocampus and frontal cortex

69. Metabolic profiling and investigations on crude extract of Olea europaea L. leaves as a potential therapeutic agent against skin cancer

70. Multipurpose composite for heavy metal sorption, antimicrobial, and antioxidant applications

87. Protective effects of kefir against zearalenone toxicity mediated by oxidative stress in cultured HCT-116 cells