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- Danilo Basili; Ji-Liang Zhang; John Herbert; Kevin Kroll; Nancy D. Denslow; Christopher J. Martyniuk; Francesco Falciani; Philipp Antczak
- Environmental science & technology 2018 v.52 no.13 pp. 7553-7565
- Micropterus salmoides; animal ovaries; databases; dynamic models; endocrine-disrupting chemicals; environmental science; estradiol; females; fish communities; gene expression; gene expression regulation; genes; gonadosomatic index; liver; males; ovarian development; prediction; quantitative polymerase chain reaction; quercetin; transcription (genetics); transcriptomics; vitellogenin
- ... In recent years, decreases in fish populations have been attributed, in part, to the effect of environmental chemicals on ovarian development. To understand the underlying molecular events we developed a dynamic model of ovary development linking gene transcription to key physiological end points, such as gonadosomatic index (GSI), plasma levels of estradiol (E2) and vitellogenin (VTG), in largemo ...