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You searched for: Publication Year 2017 Remove constraint Publication Year: 2017 Subject chemical structure Remove constraint Subject: chemical structure Subject lignans Remove constraint Subject: lignans Subject term chemical structure Remove constraint Subject term: chemical structure
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1. Antiplasmodial Securinega alkaloids from Phyllanthus fraternus: Discovery of natural (+)-allonorsecurinine

Author:
Gustav Komlaga; Grégory Genta-Jouve; Sandrine Cojean; Rita A. Dickson; Merlin L.K. Mensah; Philippe M. Loiseau; Pierre Champy; Mehdi A. Beniddir
Source:
Tetrahedron letters 2017 pp. -
ISSN:
0040-4039
Subject:
Phyllanthus fraternus; Plasmodium falciparum; Securinega; alkaloids; antimalarials; antiparasitic properties; chemical reactions; chemical structure; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... The chemical investigation of the antimalarial plant Phyllanthus fraternus G. L. Webster (Phyllanthaceae) resulted in the discovery of the Securinega alkaloid (+)-allonorsecurinine (1), previously reported as a synthetic compound, together with the known ent-norsecurinine (2), nirurine (3), bubbialine (4), epibubbialine (5) and the lignan phyllanthin (6). The structure and absolute configuration o ...
DOI:
10.1016/j.tetlet.2017.08.045

2. Asymmetric synthesis of furofurans

Author:
Manat Pohmakotr; Chutima Kuhakarn; Vichai Reutrakul; Darunee Soorukram
Source:
Tetrahedron letters 2017 pp. -
ISSN:
0040-4039
Subject:
bioactive properties; chemical reactions; chemical structure; lignans; stereochemistry; stereoselectivity
Abstract:
... Furofurans are one of the largest sub-types of classical lignans which have been found to possess a broad range of important biological activities. Tremendous efforts have been directed to develop synthetic methodologies for the synthesis of furofurans, especially in a stereoselective manner, due to their interesting bioactivities associated with the structural and stereochemical complexity. This ...
DOI:
10.1016/j.tetlet.2017.11.011

3. Diterpenoids and Lignans from Cephalotaxus fortunei

Author:
Zhao Jin-Xin; Fan Yao-Yue; Xu Jin-Biao; Gan Li-She; Xu Cheng-Hui; Ding Jian; Yue Jian-Min
Source:
Journal of natural products 2017 v.80 no.2 pp. 356-362
ISSN:
1520-6025
Subject:
Cephalotaxus; X-ray diffraction; anticarcinogenic activity; biosynthesis; branches; chemical structure; cytotoxicity; diterpenoids; inhibitory concentration 50; leaves; lignans
Abstract:
... Five new diterpenoids including two Cephalotaxus troponoids (1 and 2), two 17-nor-cephalotane-type diterpenoids (3 and 4), and an abietane-type diterpenoid (5), two new lignans (6 and 7), and a new trisnorneoligan (8) along with eight known compounds were identified from the twigs and leaves of Cephalotaxus fortunei. The structure of 11-hydroxyhainanolidol was revised as 10-hydroxyhainanolidol (9) ...
DOI:
10.1021/acs.jnatprod.6b00802

4. Enantiomeric 8-O-4′ type neolignans from red raspberry as potential inhibitors of β-amyloid aggregation

Author:
Le Zhou; Li-Li Lou; Wei Wang; Bin Lin; Jun-Ning Chen; Xiao-Bo Wang; Xiao-Xiao Huang; Shao-Jiang Song
Source:
Journal of functional foods 2017 v.37 pp. 322-329
ISSN:
1756-4646
Subject:
Alzheimer disease; Rubus idaeus; chemical composition; chemical structure; functional foods; lignans; neuroprotective effect; spectral analysis; stereochemistry
Abstract:
... Red raspberry (Rubus idaeus L.) is an edible fruit-producing species belonging to the Rosaceae family. In our search for potential agents for treating Alzheimer’s disease in this functional food, we decided to investigate the chemical constituents of red raspberry. Four pairs of enantiomeric 8-O-4′-type neolignans (1a/1b–4a/4b), including three new compounds (1a/1b and 2a), were identified from th ...
DOI:
10.1016/j.jff.2017.08.007

5. Lignans from a wild vegetable (Patrinina villosa) able to combat Alzheimer’s disease

Author:
Ming Bai; Guo-Dong Yao; Si-Fan Liu; Di Wang; Qing-Bo Liu; Xiao-Xiao Huang; Shao-Jiang Song
Source:
Journal of functional foods 2017 v.28 pp. 106-113
ISSN:
1756-4646
Subject:
Alzheimer disease; active ingredients; antioxidants; chemical structure; ethanol; functional foods; green leafy vegetables; lignans; molecular models; neuroprotective effect; salads; soups; spectral analysis; tetrahydrofuran; China; Japan; Korean Peninsula; North America
Abstract:
... Patrinina villosa Juss. is a delicious wild vegetable, which is widely distributed in China, Korea, Japan and North America. P. villosa, which smells fresh and is highly nutritious, can be made into a salad, used as greens and as a porridge and soup. Phytochemical investigation of the 70% EtOH extract showed the presence of two dibenzylbutyrolactone lignans (1–2), named Patrinians (A-B), along wit ...
DOI:
10.1016/j.jff.2016.10.024

6. Neolignan and megastigmane glucosides from the aerial parts of Isodon japonicus with cell protective effects on BaP-induced cytotoxicity

Author:
Takahiro Matsumoto; Seikou Nakamura; Souichi Nakashima; Tomoe Ohta; Keiko Ogawa; Masashi Fukaya; Junko Tsukioka; Tomohiro Hasei; Tetsushi Watanabe; Hisashi Matsuda
Source:
Phytochemistry 2017 v.137 pp. 101-108
ISSN:
0031-9422
Subject:
aerial parts; chemical structure; cytotoxicity; glucosides; lignans; nuclear magnetic resonance spectroscopy; protective effect; spectral analysis; Japan
Abstract:
... Six neolignan glucosides, named isodonosides I–VI, and a megastigmane glucoside named isodonmegastigmane I, were isolated together with 15 known compounds from the methanolic extract of aerial parts of Isodon japonicus cultivated in Tokushima, Japan. The chemical structures of the compounds were elucidated based on their MS and NMR spectroscopic analysis. The absolute configurations of the neolign ...
DOI:
10.1016/j.phytochem.2017.02.007

7. Neolignan and monoterpene glycoside from the seeds of Pharbitis nil

Author:
Seoung Rak Lee; Eunjung Moon; Ki Hyun Kim
Source:
Phytochemistry letters 2017 v.20 pp. 98-101
ISSN:
1874-3900
Subject:
Ipomoea nil; anti-inflammatory activity; chemical structure; cytotoxicity; ethanol; glycosides; inhibitory concentration 50; lignans; lipopolysaccharides; mice; monoterpenoids; nitric oxide; nuclear magnetic resonance spectroscopy; seeds; spectral analysis
Abstract:
... Phytochemical investigation of an EtOH extract of Pharbitis nil seeds (Convolvulaceae) resulted in the isolation and identification of a new neolignan, 7R,8S-threo-dihydroxydehydrodiconiferyl alcohol (1), and a new monoterpene glycoside, (3Z,7S)-7-hydroxy-3,7-dimethyl-3,8-octadienyl-β-d-glucopyranoside (2), together with a known compound, ethyl α-l-arabinofuranoside (3). The chemical structures of ...
DOI:
10.1016/j.phytol.2017.04.019

8. Neuroprotective Lignans from the Fruits of Schisandra bicolor var. tuberculata

Author:
Liu Ye; Yu Heng-Yi; Wang Yan-Mei; Tian Tian; Wu Wen-Ming; Zhou Ming; Meng Xiang-Gao; Ruan Han-Li
Source:
Journal of natural products 2017 v.80 no.4 pp. 1117-1124
ISSN:
1520-6025
Subject:
Schisandra; X-ray diffraction; chemical structure; fruits; hydrogen peroxide; irradiation; lignans; models; neuroprotective effect; spectral analysis
Abstract:
... Nine new lignans (1–9) and ten known analogues (10–19) were isolated from the fruits of Schisandra bicolor var. tuberculata. The structures of compounds 1–9 were established on the basis of spectroscopic data analysis. The absolute configuration of compound 1 was determined by single-crystal X-ray diffraction analysis with Cu Kα irradiation techniques, and the absolute configurations of compounds ...
DOI:
10.1021/acs.jnatprod.7b00035

9. A New Insecticidal Lignan Glucoside from Galium verum

Author:
Jia Chen; Chun-Chao Zhao; Jian-Hua Shao; Ju-Di Fan; Xu-Hua Huang
Source:
Chemistry of natural compounds 2017 v.53 no.4 pp. 626-628
ISSN:
0009-3130
Subject:
Galium verum; Helicoverpa armigera; Scorpiones; chemical structure; glucosides; insecticidal properties; lignans; mortality; poisoning; scorpion venoms; spectral analysis; stomach; toxicity
Abstract:
... A new lignan glucoside, galiveroside A (1), and seven known compounds (2–8), were isolated from Galium verum L. The structure of 1 was elucidated on the basis of extensive spectroscopic analyses. Compound 1, at the concentration of 5 mg/mL, showed insecticide activity to 3 age cotton bollworm with a mortality of 16.3% through stomach poisoning. When combined with a recombinant scorpion toxin rLqh ...
DOI:
10.1007/s10600-017-2075-3

10. A New Lignan Glucoside from Cyclea racemosa

Author:
Jian-Hua Shao; Xue-Wei Zhang; Zi-Ling Dong; Si-Hui Li; Ben-Jie Miao; Ke-Zhi Cheng
Source:
Chemistry of natural compounds 2017 v.53 no.6 pp. 1025-1027
ISSN:
0009-3130
Subject:
Cyclea; chemical structure; glucosides; lignans; spectral analysis
Abstract:
... A new lignan glucoside 1, along with two known lignans (2, 3), was isolated from Cyclea racemosa Oliv. Its structure was elucidated as (+)-7′-methoxylariciresinol 4-O-β-D-glucopyranoside on the basis of extensive spectroscopic analyses. ...
DOI:
10.1007/s10600-017-2193-y

11. New isobaric lignans from Refined Olive Oils as quality markers for Virgin Olive Oils

Author:
Lorenzo Cecchi; Marzia Innocenti; Fabrizio Melani; Marzia Migliorini; Lanfranco Conte; Nadia Mulinacci
Source:
Food chemistry 2017 v.219 pp. 148-157
ISSN:
0308-8146
Subject:
bleaching; chemical structure; chromatography; deodorization; extra-virgin olive oil; lignans; oil refining; Italy; Spain; Tunisia
Abstract:
... Herein we describe the influence of olive oil refining processes on the lignan profile. The detection of new isobaric lignans is suggested to reveal frauds in commercial extra-Virgin Olive Oils. We analyzed five commercial olive oils by HPLC-DAD-TOF/MS to evaluate their lignan content and detected, for the first time, some isobaric forms of natural (+)-pinoresinol and (+)-1-acetoxypinoresinol. The ...
DOI:
10.1016/j.foodchem.2016.09.132

12. New neolignan glycoside from the root of Aralia echinocaulis Hand. -Mazz

Author:
Yunzhi Li; Hui Cheng; Ren Yue; Mengmeng Duan; Mingdong Liu
Source:
Natural product research 2017 v.31 no.9 pp. 1047-1051
ISSN:
1478-6427
Subject:
Aralia; chemical structure; ionization; lignans; nuclear magnetic resonance spectroscopy; saponins
Abstract:
... A phytochemical investigation was carried out to the root of Aralia echinocauis , and a new neolignan glycoside, 3-{3,5-dimethoxy-4β- d -Glucopyranoside-2-[3-(3-β- d -Glucopyranoside-4-methoxy-phenyl)-allyl]-phenyl}-prop-2-en-1-ol (1), together with a known saponin, araliasaponin II (2) for the first time was obtained . The chemical structure of compound 1 was identified mainly by the analysis of ...
DOI:
10.1080/14786419.2016.1269095

13. Palladium-Catalyzed Acylations: One-Pot Synthesis of Indenones

Author:
Suchand Basuli; Satyanarayana Gedu
Source:
Journal of organic chemistry 2017 v.82 no.1 pp. 372-381
ISSN:
1520-6904
Subject:
acylation; aldehydes; catalytic activity; chemical structure; condensation reactions; lignans; organic chemistry; palladium; synthesis
Abstract:
... An efficient, one-pot synthesis of substituted indenones was accomplished starting from simple o-iodoketones and aldehydes. [Pd]-catalyzed direct acylation of o-iodoketones with aldehydes was employed as the key step. Subsequent intramolecular aldol condensation afforded the indenones. Notably, a variety of indenones were achieved. Significantly, the natural product neolignan was accomplished in o ...
DOI:
10.1021/acs.joc.6b02453

14. RP‐HPLC‐DAD‐ESI‐QTOF‐MS based metabolic profiling of the potential Olea europaea by‐product “wood” and its comparison with leaf counterpart

Author:
Sonda Ammar; Maria del Mar Contreras; Boutheina Gargouri; Antonio Segura‐Carretero; Mohamed Bouaziz
Source:
Phytochemical analysis 2017 v.28 no.3 pp. 217-229
ISSN:
0958-0344
Subject:
Olea europaea; aldehydes; bioactive compounds; bioactive properties; byproducts; chemical structure; coumarins; cultivars; flavonoids; high performance liquid chromatography; leaves; lignans; mass spectrometry; metabolites; metabolomics; olives; phenolic acids; phytopharmaceuticals; roots; secoiridoids; stems; sugars; trees; wood
Abstract:
... INTRODUCTION: Olea europaea L. organs such as leaves, stems and roots have been associated with numerous in vivo and in vitro biological activities and used for traditional medicinal purposes. However, tree wood is an untapped resource with little information about their chemical composition. OBJECTIVE: That is why, the objective of this study is to increase the knowledge about phytochemicals from ...
DOI:
10.1002/pca.2664

15. Reductive Bis-addition of Aromatic Aldehydes to α,β-Unsaturated Esters via the Use of Sm/Cu(I) in Air: A Route to the Construction of Furofuran Lignans

Author:
Liu Yongjun; Tian Guang; Li Jingjing; Qi Yan; Wen Yonghong; Du Feng
Source:
Journal of organic chemistry 2017 v.82 no.11 pp. 5932-5939
ISSN:
1520-6904
Subject:
acrylates; additives; air; aldehydes; chemical reactions; chemical structure; copper; lignans; maleates; organic chemistry; potassium iodide; samarium; sieves
Abstract:
... The novel bis-addition of benzaldehydes to acrylates or maleates was achieved by the direct use of samarium metal with the assistance of CuI under mild conditions under dry air, and the useful 2-hydroxylalkyl-γ-butyrolactons and lignan derivatives were thus constructed with high efficiency. The key factors that influence the reaction efficiency were investigated. The use of potassium iodide and mo ...
DOI:
10.1021/acs.joc.7b00278

16. Two new lignan-iridoid glucoside diesters from the leaves of Vaccinium bracteatum and their relative and absolute configuration determination by DFT NMR and TDDFT-ECD calculation

Author:
Yong-Mei Ren; Chang-Qiang Ke; Attila Mándi; Tibor Kurtán; Chunping Tang; Sheng Yao; Yang Ye
Source:
Tetrahedron 2017 pp. -
ISSN:
0040-4020
Subject:
Vaccinium bracteatum; biochemical pathways; chemical reactions; chemical structure; circular dichroism spectroscopy; glucosides; iridoids; leaves; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Two new lignan-iridoid glucoside diesters (2 and 3), together with their putative biosynthetic precursor 10-O-trans-caffeoyl-6α-hydroxyl-dihydromonotropein (1), were characterized from the leaves of Vaccinium bracteatum. Their planar structures and relative configuration were elucidated by spectroscopic measurements and DFT C NMR calculations, and their absolute configurations were determined by t ...
DOI:
10.1016/j.tet.2017.04.040

17. The structure proposed for apteniol D is different from that of the compound obtained by total synthesis

Author:
Toshiro Noshita; Kohei Matsumoto; Hikaru Nishikawa; Hidekazu Ouchi; Yoshitomo Hamada; Akiko Saito; Teiko Yamada
Source:
Natural product research 2017 v.31 no.2 pp. 163-168
ISSN:
1478-6427
Subject:
chemical reactions; chemical structure; copper; diphenyl ethers; lignans; spectral analysis
Abstract:
... We describe the synthesis of 4,4′-oxyneolignan, the proposed structure for naturally occurring apteniol D. The diphenyl ether moiety in 4,4′-oxyneolignan was formed via classical Ullmann ether synthesis using excess copper powder in N,N -dimethylacetamide. The spectral data of synthesised apteniol D show differences compared to those of naturally occurring apteniol D. ...
DOI:
10.1080/14786419.2016.1224867

18. α-Glucosidase inhibitors from the stem of Mangifera reba

Author:
Truc T.T. Duong; Truong N.V. Do; Hai X. Nguyen; Tho H. Le; Phu H. Dang; Nhan T. Nguyen; Tuyen N.T. Nguyen; Thao D. Nguyen; Mai T.T. Nguyen
Source:
Tetrahedron letters 2017 pp. -
ISSN:
0040-4039
Subject:
Mangifera; acarbose; alpha-glucosidase; biochemical pathways; chemical reactions; chemical structure; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Two new neolignans, named rebaneolignan A (1) and B (2), were isolated from the stem of Mangifera reba (Anacardiaceae), together with six known compounds (3–8). Their structures were elucidated on the basis of NMR spectroscopic analysis and the absolute configurations of 1 and 2 were determined by NOESY and CD data. All isolated compounds were found to possess more potent inhibitory activity, with ...
DOI:
10.1016/j.tetlet.2017.04.092