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You searched for: Publication Year 2017 Remove constraint Publication Year: 2017 Subject term adaptive immunity Remove constraint Subject term: adaptive immunity
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1. Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14 Attenuate Gardnerella vaginalis-Infected Bacterial Vaginosis in Mice

Author:
Se-Eun Jang; Jin-Ju Jeong; Su-Young Choi; Hyunji Kim; Myung Joo Han; Dong-Hyun Kim
Source:
Nutrients 2017 v.9 no.6 pp. -
ISSN:
2072-6643
Subject:
Gardnerella vaginalis; Lactobacillus acidophilus; Lactobacillus rhamnosus; adaptive immunity; enzyme activity; enzyme-linked immunosorbent assay; epithelial cells; flow cytometry; human cell lines; humans; immunoblotting; immunosuppression; ingredients; interleukin-10; interleukin-17; interleukin-1beta; intravaginal devices; lactoferrin; macrophages; mice; myeloperoxidase; neoplasm cells; oral administration; probiotics; quantitative polymerase chain reaction; splenocytes; transcription factor NF-kappa B; tumor necrosis factor-alpha; uterine cervical neoplasms; vagina; women
Abstract:
... Oral administration of a probiotic mixture (PM; Respecta®) consisting of Lactobacillus rhamnosus HN001 (L1), Lactobacillus acidophilus La-14 (L2), and lactoferrin RCXTM results in colonization of these probiotics in the vagina of healthy women. Therefore, we examined whether vaginal colonization of the PM ingredients L1 and L2 could attenuate bacterial vaginosis (BV). BV was induced in mice via β- ...
DOI:
10.3390/nu9060531
PubMed:
28545241
PubMed Central:
PMC5490510

2. Administration of a polyphenol-enriched feed to farmed sea bass (Dicentrarchus labrax L.): Kidney melanomacrophages response

Author:
Marcella Arciuli; Daniela Fiocco; Sergio Fontana; Mattia Pia Arena; Maria Antonia Frassanito; Anna Gallone
Source:
Fish & shellfish immunology 2017 v.68 pp. 404-410
ISSN:
1050-4648
Subject:
Dicentrarchus labrax; Vitis vinifera; adaptive immunity; bass; biosynthesis; diet; enzyme activity; essential oils; flavanols; gene expression; health status; immune response; immunostimulants; innate immunity; juveniles; kidneys; melanin; pathogens; polyphenols; seeds; spleen; vaccines
Abstract:
... The reinforcement of the defense mechanism of fish, through the administration of immunostimulants, is considered as a promising alternative to vaccines. Natural immunostimulants such as polyphenols, flavanoids, pigments and essential oils can modulate the innate immune response. In lower vertebrates, melano-macrophage centres, i.e. clusters of pigment-containing cells forming the extracutaneous p ...
DOI:
10.1016/j.fsi.2017.07.043

3. Alteration of the number and percentage of innate immune cells in preschool children from an e-waste recycling area

Author:
Yu Zhang; Xijin Xu; Di Sun; Junjun Cao; Yuling Zhang; Xia Huo
Source:
Ecotoxicology and environmental safety 2017 v.145 pp. 615-622
ISSN:
0147-6513
Subject:
adaptive immunity; atomic absorption spectrometry; basophils; cadmium; electronic wastes; eosinophils; flow cytometry; heavy metals; hematology; lead; monocytes; neutrophils; pollution; preschool children; recycling
Abstract:
... Heavy metal lead (Pb) and cadmium (Cd) are widespread environmental contaminants and exert detrimental effects on the immune system. We evaluated the association between Pb/Cd exposures and innate immune cells in children from an electronic waste (e-waste) recycling area. A total number of 294 preschool children were recruited, including 153 children from Guiyu (e-waste exposed group), and 141 fro ...
DOI:
10.1016/j.ecoenv.2017.07.059

4. Altered distribution of peripheral blood dendritic cell subsets in patients with pulmonary paracoccidioidomycosis

Author:
James Venturini; Ricardo Souza Cavalcante; Daniela Vanessa Moris; Márjorie de Assis Golim; Adriele Dandara Levorato; Karoline Hagatha dos Reis; Maria Sueli Parreira de Arruda; Rinaldo Poncio Mendes
Source:
Acta tropica 2017 pp. -
ISSN:
0001-706X
Subject:
Paracoccidioides; adaptive immunity; adults; blood serum; chemokine CCL3; complications (disease); dendritic cells; enzyme-linked immunosorbent assay; fibroblast growth factor 2; fibrosis; flow cytometry; fungi; hypoxia; immune response; interleukin-10; interleukin-18; interleukin-1beta; lungs; models; mucosa; mycoses; patients; pulmonary emphysema; tumor necrosis factor-alpha; Latin America
Abstract:
... Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi from the genus Paracoccidioides in Latin America. PCM-patients (PCM-p) are classified as having acute/subacute or chronic (CF) clinical forms. CF is responsible for 75% − 90% of all cases, affects mainly adults over 30 years old and the clinical manifestation are associated mainly with lungs and mucosa of upper airdigestive tract. ...
DOI:
10.1016/j.actatropica.2017.06.007

5. Antibodies: From novel repertoires to defining and refining the structure of biologically important targets

Author:
Paul J. Conroy; Ruby H.P. Law; Tom T. Caradoc-Davies; James C. Whisstock
Source:
Methods 2017 v.116 pp. 12-22
ISSN:
1046-2023
Subject:
adaptive immunity; antibodies; antigens; crystallography; high-throughput nucleotide sequencing; human health; humans; rodents; screening
Abstract:
... Antibodies represent a highly successful class of molecules that bind a wide-range of targets in therapeutic-, diagnostic- and research-based applications. The antibody repertoire is composed of the building blocks required to develop an effective adaptive immune response against foreign insults. A number of species have developed novel genetic and structural mechanisms from which they derive thes ...
DOI:
10.1016/j.ymeth.2017.01.003

6. Antigenic GM3 Lactone Mimetic Molecule Integrated Mannosylated Glycopeptide Nanofibers for the Activation and Maturation of Dendritic Cells

Author:
Gunay Gokhan; Sardan Ekiz Melis; Ferhati Xhenti; Richichi Barbara; Nativi Cristina; Tekinay Ayse B.; Guler Mustafa O.
Source:
ACS Applied Materials & Interfaces 2017 v.9 no.19 pp. 16035-16042
ISSN:
1944-8252
Subject:
adaptive immunity; antigens; dendritic cells; glycopeptides; nanofibers; neoplasms; pathogens; vaccination
Abstract:
... The ability of dendritic cells to coordinate innate and adaptive immune responses makes them essential targets for vaccination strategies. Presentation of specific antigens by dendritic cells is required for the activation of the immune system against many pathogens and tumors, and nanoscale materials can be functionalized for active targeting of dendritic cells. In this work, we integrated an imm ...
DOI:
10.1021/acsami.7b04094

7. Application of the CRISPR gene‐editing technique in insect functional genome studies – a review

Author:
Yubao Cui; Jin‐Lu Sun; LiLi Yu
Source:
Entomologia experimentalis et applicata 2017 v.162 no.2 pp. 124-132
ISSN:
0013-8703
Subject:
CRISPR sequences; DNA; Danio rerio; Diptera; Nematoda; adaptive immunity; bacteria; bacteriophages; gene editing; genome; humans; insects; mice; rats; ribonucleases; yeasts
Abstract:
... The clustered regularly interspaced short palindromic repeats (CRISPR) structural family form an acquired immune system in bacteria that is able to degrade invading virus or phage DNA. The CRISPR/Cas system has been co‐opted as an RNA‐mediated nuclease for use in targeted genome engineering. The CRISPR/Cas system provides a novel tool for manipulating genomic DNA using an approach that is simple, ...
DOI:
10.1111/eea.12530

8. The Arp2/3 complex binding protein HS1 is required for efficient dendritic cell random migration and force generation

Author:
Amy C. Bendell; Edward K. Williamson; Christopher S. Chen; Janis K. Burkhardt; Daniel A. Hammer
Source:
Integrative biology 2017 v.9 no.8 pp. 695-708
ISSN:
1757-9708
Subject:
actin; adaptive immunity; binding proteins; cell movement; dendritic cells; detectors; lymph nodes; microfilaments; polymerization; wasps
Abstract:
... Dendritic cell migration to the T-cell-rich areas of the lymph node is essential for their ability to initiate the adaptive immune response. While it has been shown that the actin cytoskeleton is required for normal DC migration, the role of many of the individual cytoskeletal molecules is poorly understood. In this study, we investigated the contribution of the Arp2/3 complex binding protein, hae ...
DOI:
10.1039/c7ib00070g
PubMed:
28678266
PubMed Central:
PMC5830129

9. Assessing in vivo digestibility and effects on immune system of sheep fed alfalfa hay supplemented with a fixed amount of Ulva rigida and Gracilaria vermiculophylla

Author:
Ana R. J. Cabrita; Alexandra Correia; Ana R. Rodrigues; Paulo P. Cortez; Manuel Vilanova; António J.M. Fonseca
Source:
Journal of applied phycology 2017 v.29 no.2 pp. 1057-1067
ISSN:
0921-8971
Subject:
B-lymphocytes; Gracilaria; Ulva rigida; adaptive immunity; alfalfa hay; diet; digestibility; digestible energy; ecosystems; hematologic tests; immune response; in vivo studies; macroalgae; neutrophils; organic matter; polysaccharides; reactive oxygen species; rumen; sheep
Abstract:
... Ruminants could be the most suitable domestic animals to be supplemented with seaweeds as the rumen ecosystem might provide the animal the ability to use these feed resources by breaking down the complex polysaccharides. The objective of the present in vivo study was to determine the digestibility and the effects on the immune system of one green (Ulva rigida) and one red (Gracilaria vermiculophyl ...
DOI:
10.1007/s10811-016-0999-9

10. Autophagy induced by infectious hematopoietic necrosis virus inhibits intracellular viral replication and extracellular viral yields in epithelioma papulosum cyprini cell line

Author:
Jing-Zhuang Zhao; Li-Ming Xu; Miao Liu; Zhen-yu Zhang; Jia-Sheng Yin; Hong-Bai Liu; Tong-Yan Lu
Source:
Developmental and comparative immunology 2017 v.77 pp. 88-94
ISSN:
0145-305X
Subject:
Infectious hematopoietic necrosis virus; Salmonidae; Western blotting; adaptive immunity; aquaculture industry; autophagy; cell lines; disease severity; electron microscopy; fluorescence microscopy; pathogens; rapamycin; virus replication
Abstract:
... Infectious hematopoietic necrosis virus (IHNV) is a common pathogen that causes severe disease in the salmonid aquaculture industry. Recent work demonstrated that autophagy plays an important role in pathogen invasion by activating innate and adaptive immunity. This study investigated the relationship between IHNV and autophagy in epithelioma papulosum cyprini cells. The electron microscopy result ...
DOI:
10.1016/j.dci.2017.07.025

11. Axl signaling induces development of natural killer cells in vitro and in vivo

Author:
Eun-Mi Kim; Eun-Hee Lee; Hwa-Yeon Lee; Ha-Rim Choi; Kon-Young Ji; Su-Man Kim; Kwang Dong Kim; Hyung-Sik Kang
Source:
Protoplasma 2017 v.254 no.2 pp. 1091-1101
ISSN:
0033-183X
Subject:
adaptive immunity; antibodies; antigen-presenting cells; autoimmunity; bone marrow; cell viability; chemical elements; gene expression regulation; genes; hematopoietic stem cells; innate immunity; interferon-gamma; ligands; metastasis; mice; natural killer cells; neoplasm cells; receptor protein-tyrosine kinase; receptors
Abstract:
... Natural killer (NK) cells have been well known to play a critical role in innate immunity, but they are also capable of regulating adaptive immunity through the induction of T cell-mediated memory response and B cell-mediated autoimmune response. NK cells are differentiated from hematopoietic stem cells (HSCs) in the bone marrow (BM), and a series of surface molecules are expressed on NK cells in ...
DOI:
10.1007/s00709-016-1016-5

12. BCG immune activation reduces growth and angiogenesis in an in vitro model of head and neck squamous cell carcinoma

Author:
Carolina Sánchez-Rodríguez; Keyliz Peraza Cruces; Juan Riestra Ayora; Eduardo Martín-Sanz; Ricardo Sanz-Fernández
Source:
Vaccine 2017 v.35 no.47 pp. 6395-6403
ISSN:
0264-410X
Subject:
BCG vaccine; CD8-positive T-lymphocytes; adaptive immunity; angiogenesis; angiopoietin-2; antigens; antineoplastic activity; apoptosis; caspase-3; coculture; cytotoxicity; endothelial cells; head; humans; immunosuppression; interferon-gamma; interleukin-6; models; morbidity; neck; patients; squamous cell carcinoma; tumor necrosis factor-alpha; vaccination; vascular endothelial growth factors
Abstract:
... Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers worldwide and is associated with poor survival and significant treatment morbidity. The immune profile in patients with HNSCC is immunosuppressive and presents cytokine-mediated adaptive immune responses, triggered apoptosis of T cells, and alterations in antigen processing machinery. Bacille Calmette-Guerin (BCG) im ...
DOI:
10.1016/j.vaccine.2017.10.008

13. Bacterial Virulence Factors: Secreted for Survival

Author:
Aditya Kumar Sharma; Neha Dhasmana; Neha Dubey; Nishant Kumar; Aakriti Gangwal; Meetu Gupta; Yogendra Singh
Source:
Indian journal of microbiology 2017 v.57 no.1 pp. 1-10
ISSN:
0046-8991
Subject:
Mycobacterium; adaptive immunity; adhesion; animal pathogens; bacteria; chemical elements; virulence
Abstract:
... Virulence is described as an ability of an organism to infect the host and cause a disease. Virulence factors are the molecules that assist the bacterium colonize the host at the cellular level. These factors are either secretory, membrane associated or cytosolic in nature. The cytosolic factors facilitate the bacterium to undergo quick adaptive—metabolic, physiological and morphological shifts. T ...
DOI:
10.1007/s12088-016-0625-1
PubMed:
28148975
PubMed Central:
PMC5243249

14. Bacterial ghosts as adjuvants: mechanisms and potential

Author:
Irshad A. Hajam; Pervaiz A. Dar; Gayeon Won; John Hwa Lee
Source:
Veterinary research 2017 v.48 no.1 pp. 37
ISSN:
1297-9716
Subject:
B-lymphocytes; Gram-negative bacteria; adaptive immunity; adjuvants; agonists; animal models; antigens; cytokines; dendritic cells; immune response; immunostimulants; lymph nodes; transfection; vaccines
Abstract:
... Bacterial ghosts (BG) are empty cell envelopes derived from Gram-negative bacteria. They contain many innate immunostimulatory agonists, and are potent activators of a broad range of cell types involved in innate and adaptive immunity. Several considerable studies have demonstrated the effectiveness of BG as adjuvants as well as their ability to induce proinflammatory cytokine production by a rang ...
DOI:
10.1186/s13567-017-0442-5
PubMed:
28645300
PubMed Central:
PMC5482964

15. Bead-based flow-cytometry for semi-quantitative analysis of complex membrane vesicle populations released by bacteria and host cells

Author:
Charlotte Volgers; Birke J. Benedikter; Gert E. Grauls; Paul H.M. Savelkoul; Frank R.M. Stassen
Source:
Microbiological research 2017 v.200 pp. 25-32
ISSN:
0944-5013
Subject:
adaptive immunity; bacteria; environmental factors; flow cytometry; pathogenicity; screening
Abstract:
... During infection, the release of nano-sized membrane vesicle is a process which is common both for bacteria and host cells. Host cell-derived membrane vesicles can be involved in innate and adaptive immunity whereas bacterial membrane vesicles can contribute to bacterial pathogenicity. To study the contribution of both membrane vesicle populations during infection is highly complicated as most ves ...
DOI:
10.1016/j.micres.2017.04.003

16. Bioengineering towards self-assembly of particulate vaccines

Author:
Bernd H.A. Rehm
Source:
Current opinion in biotechnology 2017 v.48 pp. 42-53
ISSN:
0958-1669
Subject:
adaptive immunity; antigen-presenting cells; antigens; bioengineering; immune response; infectious diseases; pathogens; polyesters; proteins; subunit vaccines
Abstract:
... There is an unmet demand for safe and efficient vaccines for prevention of various infectious diseases. Subunit vaccines comprise selected pathogen specific antigens are a safe alternative to whole organism vaccines. However they often lack immunogenicity. Natural and synthetic self-assembling polymers and proteins will be reviewed in view their use to encapsulate and/or display antigens to serve ...
DOI:
10.1016/j.copbio.2017.03.018

17. Biomaterials innovation for next generation ex vivo immune tissue engineering

Author:
Ankur Singh
Source:
Biomaterials 2017 pp. -
ISSN:
0142-9612
Subject:
T-lymphocytes; adaptive immunity; animal models; biocompatible materials; immunomodulation; immunotherapy; lymphatic system; medicine; mice; natural selection; researchers; tissue culture; tissue engineering; tissues
Abstract:
... Primary and secondary lymphoid organs are tissues that facilitate differentiation of B and T cells, leading to the induction of adaptive immune responses. These organs are present in the body from birth and are also recognized as locations where self-reactive B and T cells can be eliminated during the natural selection process. Many insights into the mechanisms that control the process of immune c ...
DOI:
10.1016/j.biomaterials.2017.03.015

18. Bovine single chain Fv antibody inhibits bovine herpesvirus-1 infectivity by targeting viral glycoprotein D

Author:
Jian Xu; Jing Wu; Bo Jiang; Houjun He; Xixi Zhang; Xiaoyang Li; Dawei Yang; Xiufen Huang; Joshua E. Sealy; Munir Iqbal; Yongqing Li
Source:
Applied microbiology and biotechnology 2017 v.101 no.23-24 pp. 8331-8344
ISSN:
0175-7598
Subject:
epitopes; hybridomas; Bovine alphaherpesvirus 1; molecular models; glycoproteins; adaptive immunity; cattle; Western blotting; enzyme-linked immunosorbent assay; monoclonal antibodies; pathogenicity; genes; neutralizing antibodies; viruses; kidneys; recombinant antibodies; fluorescent antibody technique; Escherichia coli
Abstract:
... Glycoprotein D (gD) of bovine herpesvirus-1 (BoHV-1) is essential for attachment and penetration of cells during infection and is a major target for neutralizing antibodies during an adaptive immune response. Currently there are no recombinant antibodies capable of binding gD epitopes for use in treating BoHV-1 infection. In this study, a bovine scFv gene derived from a hybridoma secreting monoclo ...
DOI:
10.1007/s00253-017-8566-0

19. CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis

Author:
Raquel Ferraz; Clarissa F. Cunha; Maria Inês F. Pimentel; Marcelo R. Lyra; Tatiana Pereira-Da-Silva; Armando O. Schubach; Alda Maria Da-Cruz; Alvaro Luiz Bertho
Source:
Parasites & vectors 2017 v.10 no.1 pp. 219
ISSN:
1756-3305
Subject:
CD8-positive T-lymphocytes; Leishmania braziliensis; adaptive immunity; cutaneous leishmaniasis; cytokines; cytotoxicity; dendritic cells; flow cytometry; immune response; inflammation; macrophages; natural killer cells; pathogenesis; patients; therapeutics
Abstract:
... BACKGROUND: Cutaneous leishmaniasis (CL) is caused by Leishmania (Viannia) braziliensis, which infects dermal macrophages and dendritic cells, causing an intense immune-mediated-tissue inflammation and a skin ulcer with elevated borders that can heal spontaneously or after antimonial therapy. The resolution of lesions depends on an adaptive immune response, and cytotoxic cells seem to have a funda ...
DOI:
10.1186/s13071-017-2152-2
PubMed:
28468680
PubMed Central:
PMC5415843

20. CD44 enhances macrophage phagocytosis and plays a protective role in Streptococcus equi subsp. zooepidemicus infection

Author:
Qiang Fu; Zigong Wei; Pingping Xiao; Yaosheng Chen; Xiaohong Liu
Source:
Veterinary microbiology 2017 v.198 pp. 121-126
ISSN:
0378-1135
Subject:
Streptococcus equi subsp. zooepidemicus; adaptive immunity; death; macrophages; mice; pathogens; phagocytosis; protective effect
Abstract:
... Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) is an important pathogen associated with a wide range of diseases in many mammalian species. CD44 is a transmembrane adhesion molecule involved in innate and adaptive immune responses. The aim of this study was to determine the protective role of CD44 during S. zooepidemicus infection. CD44-deficient mice exhibited reduced macrophage accum ...
DOI:
10.1016/j.vetmic.2016.12.030