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You searched for: Publication Year 2017 Remove constraint Publication Year: 2017 Subject term adaptive immunity Remove constraint Subject term: adaptive immunity
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1. Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14 Attenuate Gardnerella vaginalis-Infected Bacterial Vaginosis in Mice

Author:
Se-Eun Jang; Jin-Ju Jeong; Su-Young Choi; Hyunji Kim; Myung Joo Han; Dong-Hyun Kim
Source:
Nutrients 2017 v.9 no.6 pp. -
ISSN:
2072-6643
Subject:
Gardnerella vaginalis; Lactobacillus acidophilus; Lactobacillus rhamnosus; adaptive immunity; enzyme activity; enzyme-linked immunosorbent assay; epithelial cells; flow cytometry; human cell lines; humans; immunoblotting; immunosuppression; ingredients; interleukin-10; interleukin-17; interleukin-1beta; intravaginal devices; lactoferrin; macrophages; mice; myeloperoxidase; neoplasm cells; oral administration; probiotics; quantitative polymerase chain reaction; splenocytes; transcription factor NF-kappa B; tumor necrosis factor-alpha; uterine cervical neoplasms; vagina; women
Abstract:
... Oral administration of a probiotic mixture (PM; Respecta®) consisting of Lactobacillus rhamnosus HN001 (L1), Lactobacillus acidophilus La-14 (L2), and lactoferrin RCXTM results in colonization of these probiotics in the vagina of healthy women. Therefore, we examined whether vaginal colonization of the PM ingredients L1 and L2 could attenuate bacterial vaginosis (BV). BV was induced in mice via β- ...
DOI:
10.3390/nu9060531
PubMed:
28545241
PubMed Central:
PMC5490510

2. A Luciferase Immunoprecipitation System (LIPS) assay for profiling human norovirus antibodies

Author:
Christine M. Tin; Lijuan Yuan; Rachel J. Dexter; Gabriel I. Parra; Tammy Bui; Kim Y. Green; Stanislav V. Sosnovtsev
Source:
Journal of virological methods 2017 pp. -
ISSN:
0166-0934
Subject:
Norovirus; adaptive immunity; antibodies; antibody specificity; coat proteins; enzyme-linked immunosorbent assay; genotype; humans; luciferase; plasmids; precipitin tests; recombinant proteins; vaccination
Abstract:
... A luciferase immunoprecipitation systems (LIPS) assay was developed to define the antigenic specificity and titer of antibodies directed against human norovirus (HuNoV). Recombinant proteins, expressed by plasmid constructs encoding Renilla luciferase (Ruc) fused to the full-length HuNoV major capsid protein (VP1) (Ruc-antigen), were generated for ten HuNoV strains. In addition, subdomain construc ...
DOI:
10.1016/j.jviromet.2017.06.017
PubMed:
28673856
PubMed Central:
PMC5592151

3. A Severe Ranavirus Outbreak in Captive, Wild-Caught Box Turtles

Author:
Steven J. A. Kimble; April J. Johnson; Rod N. Williams; Jason T. Hoverman
Source:
EcoHealth 2017 v.14 no.4 pp. 810-815
ISSN:
1612-9202
Subject:
Ranavirus; Terrapene; adaptive immunity; captive animals; clinical examination; mortality; nose; quantitative polymerase chain reaction
Abstract:
... A Ranavirus outbreak in a captive population of wild-caught individuals was monitored using clinical evaluations and real-time PCR in 317 wild box turtles held in captivity during translocation. During the 2-year study period, the population experienced 71.6% mortality, suggesting that ranaviruses can rapidly attenuate populations. Wide variation in infection rate (7–94% per sampling period) was o ...
DOI:
10.1007/s10393-017-1263-8

4. A bead based multiplex immunoassay detects Piscine orthoreovirus specific antibodies in Atlantic salmon (Salmo salar)

Author:
Lena Hammerlund Teige; Morten Lund; Hanne M. Haatveit; Magnus Vikan Røsæg; Øystein Wessel; Maria K. Dahle; Anne K. Storset
Source:
Fish & shellfish immunology 2017 v.63 pp. 491-499
ISSN:
1050-4648
Subject:
Orthoreovirus; Salmo salar; adaptive immunity; antibodies; antibody formation; aquaculture; coat proteins; disease control; fish; immunoassays; immunoglobulin M; inflammation; pathogens; skeletal muscle; vaccination; vaccine development; viral nonstructural proteins; viruses
Abstract:
... Future growth in aquaculture relies strongly on the control of diseases and pathogens. Vaccination has been a successful strategy for obtaining control of bacterial diseases in fish, but for viral diseases, vaccine development has been more challenging. Effective long-term protection against viral infections is not yet fully understood for fish, and in addition, optimal tools to monitor adaptive i ...
DOI:
10.1016/j.fsi.2017.02.043

5. A mannose-specific C-type lectin from Fenneropenaeus merguiensis exhibited antimicrobial activity to mediate shrimp innate immunity

Author:
Phanthipha Runsaeng; Peerapong Puengyam; Prapaporn Utarabhand
Source:
Molecular Immunology 2017 pp. -
ISSN:
0161-5890
Subject:
Fenneropenaeus merguiensis; Vibrio harveyi; White spot syndrome virus; acids; adaptive immunity; agglutination; antimicrobial properties; calcium; complementary DNA; double-stranded RNA; gene expression; heart; hemolymph; hepatopancreas; innate immunity; intestines; lectins; lipopolysaccharides; mannose; messenger RNA; microbial growth; molecular weight; mortality; open reading frames; pathogens; rapid amplification of cDNA ends; receptors; reverse transcriptase polymerase chain reaction; shrimp; signal peptide; stomach
Abstract:
... Being one type of pattern recognition receptors (PRRs), lectins exhibit a crucial role in the defense mechanism of invertebrates which are deficient in an adaptive immune system. A new C-type lectin called FmLC3 was isolated from hepatopancreas of Fenneropenaeus merguiensis by cloning approaches, RT-PCR and 5′ and 3′ RACE (rapid amplification of cDNA ends). A full-length cDNA of FmLC3 contains 607 ...
DOI:
10.1016/j.molimm.2017.10.005

6. A mechanistic study of Toxoplasma gondii ROP18 inhibiting differentiation of C17.2 neural stem cells

Author:
Xian Zhang; Rui Su; Zhengyang Cheng; Wanbo Zhu; Yelin Li; Yongzhong Wang; Jian Du; Yihong Cai; Qingli Luo; Jilong Shen; Li Yu
Source:
Parasites & vectors 2017 v.10 no.1 pp. 585
ISSN:
1756-3305
Subject:
Adenoviridae; Toxoplasma gondii; adaptive immunity; beta catenin; brain; congenital abnormalities; neurons; parasites; signal transduction; stem cells; transfection; virulence
Abstract:
... BACKGROUND: Congenital infection of Toxoplasma gondii is an important factor causing birth defects. The neural stem cells (NSCs) are found to be one of the target cells for the parasite during development of the brain. As a key virulence factor of the parasite that hijacks host cellular functions, ROP18 has been demonstrated to mediate the inhibition of host innate and adaptive immune responses th ...
DOI:
10.1186/s13071-017-2529-2
PubMed:
29169404
PubMed Central:
PMC5701453

7. A novel ex vivo immunoproteomic approach characterising Fasciola hepatica tegumental antigens identified using immune antibody from resistant sheep

Author:
Timothy C. Cameron; Ira Cooke; Pierre Faou; Hayley Toet; David Piedrafita; Neil Young; Vignesh Rathinasamy; Travis Beddoe; Glenn Anderson; Robert Dempster; Terry W. Spithill
Source:
International journal for parasitology 2017 v.47 no.9 pp. 555-567
ISSN:
0020-7519
Subject:
Fasciola gigantica; Fasciola hepatica; adaptive immunity; adults; amino acids; antibodies; antigens; cytoskeleton; cytotoxicity; definitive hosts; exocytosis; fascioliasis; flukes; glucose transporters; immune response; immunoglobulin G; immunotherapy; juveniles; lysosomes; mass spectrometry; metacercariae; multiple drug resistance; protein secretion; sequence homology; sheep; vaccines; vacuoles
Abstract:
... A more thorough understanding of the immunological interactions between Fasciola spp. and their hosts is required if we are to develop new immunotherapies to control fasciolosis. Deeper knowledge of the antigens that are the target of the acquired immune responses of definitive hosts against both Fasciola hepatica and Fasciola gigantica will potentially identify candidate vaccine antigens. Indones ...
DOI:
10.1016/j.ijpara.2017.02.004

8. Administration of a polyphenol-enriched feed to farmed sea bass (Dicentrarchus labrax L.): Kidney melanomacrophages response

Author:
Marcella Arciuli; Daniela Fiocco; Sergio Fontana; Mattia Pia Arena; Maria Antonia Frassanito; Anna Gallone
Source:
Fish & shellfish immunology 2017 v.68 pp. 404-410
ISSN:
1050-4648
Subject:
Dicentrarchus labrax; Vitis vinifera; adaptive immunity; bass; biosynthesis; diet; enzyme activity; essential oils; flavanols; gene expression; health status; immune response; immunostimulants; innate immunity; juveniles; kidneys; melanin; pathogens; polyphenols; seeds; spleen; vaccines
Abstract:
... The reinforcement of the defense mechanism of fish, through the administration of immunostimulants, is considered as a promising alternative to vaccines. Natural immunostimulants such as polyphenols, flavanoids, pigments and essential oils can modulate the innate immune response. In lower vertebrates, melano-macrophage centres, i.e. clusters of pigment-containing cells forming the extracutaneous p ...
DOI:
10.1016/j.fsi.2017.07.043

9. Alteration of the number and percentage of innate immune cells in preschool children from an e-waste recycling area

Author:
Yu Zhang; Xijin Xu; Di Sun; Junjun Cao; Yuling Zhang; Xia Huo
Source:
Ecotoxicology and environmental safety 2017 v.145 pp. 615-622
ISSN:
0147-6513
Subject:
adaptive immunity; atomic absorption spectrometry; basophils; cadmium; electronic wastes; eosinophils; flow cytometry; heavy metals; hematology; lead; monocytes; neutrophils; pollution; preschool children; recycling
Abstract:
... Heavy metal lead (Pb) and cadmium (Cd) are widespread environmental contaminants and exert detrimental effects on the immune system. We evaluated the association between Pb/Cd exposures and innate immune cells in children from an electronic waste (e-waste) recycling area. A total number of 294 preschool children were recruited, including 153 children from Guiyu (e-waste exposed group), and 141 fro ...
DOI:
10.1016/j.ecoenv.2017.07.059

10. Altered distribution of peripheral blood dendritic cell subsets in patients with pulmonary paracoccidioidomycosis

Author:
James Venturini; Ricardo Souza Cavalcante; Daniela Vanessa Moris; Márjorie de Assis Golim; Adriele Dandara Levorato; Karoline Hagatha dos Reis; Maria Sueli Parreira de Arruda; Rinaldo Poncio Mendes
Source:
Acta tropica 2017 pp. -
ISSN:
0001-706X
Subject:
Paracoccidioides; adaptive immunity; adults; blood serum; chemokine CCL3; complications (disease); dendritic cells; enzyme-linked immunosorbent assay; fibroblast growth factor 2; fibrosis; flow cytometry; fungi; hypoxia; immune response; interleukin-10; interleukin-18; interleukin-1beta; lungs; models; mucosa; mycoses; patients; pulmonary emphysema; tumor necrosis factor-alpha; Latin America
Abstract:
... Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi from the genus Paracoccidioides in Latin America. PCM-patients (PCM-p) are classified as having acute/subacute or chronic (CF) clinical forms. CF is responsible for 75% − 90% of all cases, affects mainly adults over 30 years old and the clinical manifestation are associated mainly with lungs and mucosa of upper airdigestive tract. ...
DOI:
10.1016/j.actatropica.2017.06.007

11. An assessment of immune and stress responsiveness in Holstein-Friesian cows selected for high and low feed conversion efficiency

Author:
J. W. Aleri; B. C. Hine; M. F. Pyman; P. D. Mansell; W. J. Wales; B. Mallard; A. D. Fisher
Source:
Animal production science 2017 v.57 no.2 pp. 244-251
ISSN:
1836-0939
Subject:
Holstein; adaptive immunity; cortisol; cows; feed conversion; lactation; phenotype; vaccines
Abstract:
... The objective of this study was to assess the immune and stress responsiveness of cows identified as extremely high and low feed conversion efficiency phenotypes. The study utilised 16 Holstein-Friesian cows in their third to fourth lactation, and identified as having either extremely high (n = 8) or extremely low (n = 8) feed conversion efficiency. A commercial vaccine was used to induce measurab ...
DOI:
10.1071/AN15406

12. An experimental approach to the immuno-modulatory basis of host-parasite local adaptation in tapeworm-infected sticklebacks

Author:
Madeleine Hamley; Frederik Franke; Joachim Kurtz; Jörn Peter Scharsack
Source:
Experimental parasitology 2017 pp. -
ISSN:
0014-4894
Subject:
Gasterosteus aculeatus; Schistocephalus; adaptive immunity; allopatry; coevolution; excretory-secretory products; host-parasite relationships; hosts; leukocytes; sympatry; tapeworms; virulence; Germany; Iceland; Spain
Abstract:
... The evolutionary arms race of hosts and parasites often results in adaptations, which may differ between populations. Investigation of such local adaptation becomes increasingly important to understand dynamics of host-parasite interactions and co-evolution. To this end we performed an infection experiment involving pairs of three-spined sticklebacks and their tapeworm parasite Schistocephalus sol ...
DOI:
10.1016/j.exppara.2017.03.004

13. An increasing, potentially measles-susceptible population over time after vaccination in Korea

Author:
Hae Ji Kang; Young Woo Han; Su Jin Kim; You-Jin Kim; A-Reum Kim; Joo Ae Kim; Hee-Dong Jung; Hye Eun Eom; Ok Park; Sung Soon Kim
Source:
Vaccine 2017 v.35 no.33 pp. 4126-4132
ISSN:
0264-410X
Subject:
adaptive immunity; adolescents; antibodies; enzyme immunoassays; herd immunity; infants; seroprevalence; surveys; vaccination; vaccines; viruses; young adults; Korean Peninsula
Abstract:
... In Korea, measles occurs mainly in infants <12months of age, who are unvaccinated. In addition, vaccine populations, including adolescents and young adults, can become infected though importation. Thus, the question arises whether the current level of herd immunity in Korea is now insufficient for protecting against measles infection.Age-specific measles seroprevalence was evaluated by performing ...
DOI:
10.1016/j.vaccine.2017.06.058

14. Antibodies: From novel repertoires to defining and refining the structure of biologically important targets

Author:
Paul J. Conroy; Ruby H.P. Law; Tom T. Caradoc-Davies; James C. Whisstock
Source:
Methods 2017 v.116 pp. 12-22
ISSN:
1046-2023
Subject:
adaptive immunity; antibodies; antigens; crystallography; high-throughput nucleotide sequencing; human health; humans; rodents; screening
Abstract:
... Antibodies represent a highly successful class of molecules that bind a wide-range of targets in therapeutic-, diagnostic- and research-based applications. The antibody repertoire is composed of the building blocks required to develop an effective adaptive immune response against foreign insults. A number of species have developed novel genetic and structural mechanisms from which they derive thes ...
DOI:
10.1016/j.ymeth.2017.01.003

15. Antigenic GM3 Lactone Mimetic Molecule Integrated Mannosylated Glycopeptide Nanofibers for the Activation and Maturation of Dendritic Cells

Author:
Gunay Gokhan; Sardan Ekiz Melis; Ferhati Xhenti; Richichi Barbara; Nativi Cristina; Tekinay Ayse B.; Guler Mustafa O.
Source:
ACS Applied Materials & Interfaces 2017 v.9 no.19 pp. 16035-16042
ISSN:
1944-8252
Subject:
adaptive immunity; antigens; dendritic cells; glycopeptides; nanofibers; neoplasms; pathogens; vaccination
Abstract:
... The ability of dendritic cells to coordinate innate and adaptive immune responses makes them essential targets for vaccination strategies. Presentation of specific antigens by dendritic cells is required for the activation of the immune system against many pathogens and tumors, and nanoscale materials can be functionalized for active targeting of dendritic cells. In this work, we integrated an imm ...
DOI:
10.1021/acsami.7b04094

16. Application of the CRISPR gene‐editing technique in insect functional genome studies – a review

Author:
Yubao Cui; Jin‐Lu Sun; LiLi Yu
Source:
Entomologia experimentalis et applicata 2017 v.162 no.2 pp. 124-132
ISSN:
0013-8703
Subject:
CRISPR sequences; DNA; Danio rerio; Diptera; Nematoda; adaptive immunity; bacteria; bacteriophages; gene editing; genome; humans; insects; mice; rats; ribonucleases; yeasts
Abstract:
... The clustered regularly interspaced short palindromic repeats (CRISPR) structural family form an acquired immune system in bacteria that is able to degrade invading virus or phage DNA. The CRISPR/Cas system has been co‐opted as an RNA‐mediated nuclease for use in targeted genome engineering. The CRISPR/Cas system provides a novel tool for manipulating genomic DNA using an approach that is simple, ...
DOI:
10.1111/eea.12530

17. Assessing in vivo digestibility and effects on immune system of sheep fed alfalfa hay supplemented with a fixed amount of Ulva rigida and Gracilaria vermiculophylla

Author:
Ana R. J. Cabrita; Alexandra Correia; Ana R. Rodrigues; Paulo P. Cortez; Manuel Vilanova; António J.M. Fonseca
Source:
Journal of applied phycology 2017 v.29 no.2 pp. 1057-1067
ISSN:
0921-8971
Subject:
B-lymphocytes; Gracilaria; Ulva rigida; adaptive immunity; alfalfa hay; diet; digestibility; digestible energy; ecosystems; hematologic tests; immune response; in vivo studies; macroalgae; neutrophils; organic matter; polysaccharides; reactive oxygen species; rumen; sheep
Abstract:
... Ruminants could be the most suitable domestic animals to be supplemented with seaweeds as the rumen ecosystem might provide the animal the ability to use these feed resources by breaking down the complex polysaccharides. The objective of the present in vivo study was to determine the digestibility and the effects on the immune system of one green (Ulva rigida) and one red (Gracilaria vermiculophyl ...
DOI:
10.1007/s10811-016-0999-9

18. Autophagy induced by infectious hematopoietic necrosis virus inhibits intracellular viral replication and extracellular viral yields in epithelioma papulosum cyprini cell line

Author:
Jing-Zhuang Zhao; Li-Ming Xu; Miao Liu; Zhen-yu Zhang; Jia-Sheng Yin; Hong-Bai Liu; Tong-Yan Lu
Source:
Developmental and comparative immunology 2017 v.77 pp. 88-94
ISSN:
0145-305X
Subject:
Infectious hematopoietic necrosis virus; Salmonidae; Western blotting; adaptive immunity; aquaculture industry; autophagy; cell lines; disease severity; electron microscopy; fluorescence microscopy; pathogens; rapamycin; virus replication
Abstract:
... Infectious hematopoietic necrosis virus (IHNV) is a common pathogen that causes severe disease in the salmonid aquaculture industry. Recent work demonstrated that autophagy plays an important role in pathogen invasion by activating innate and adaptive immunity. This study investigated the relationship between IHNV and autophagy in epithelioma papulosum cyprini cells. The electron microscopy result ...
DOI:
10.1016/j.dci.2017.07.025

19. Axl signaling induces development of natural killer cells in vitro and in vivo

Author:
Eun-Mi Kim; Eun-Hee Lee; Hwa-Yeon Lee; Ha-Rim Choi; Kon-Young Ji; Su-Man Kim; Kwang Dong Kim; Hyung-Sik Kang
Source:
Protoplasma 2017 v.254 no.2 pp. 1091-1101
ISSN:
0033-183X
Subject:
adaptive immunity; antibodies; antigen-presenting cells; autoimmunity; bone marrow; cell viability; chemical elements; gene expression regulation; genes; hematopoietic stem cells; innate immunity; interferon-gamma; ligands; metastasis; mice; natural killer cells; neoplasm cells; receptor protein-tyrosine kinase; receptors
Abstract:
... Natural killer (NK) cells have been well known to play a critical role in innate immunity, but they are also capable of regulating adaptive immunity through the induction of T cell-mediated memory response and B cell-mediated autoimmune response. NK cells are differentiated from hematopoietic stem cells (HSCs) in the bone marrow (BM), and a series of surface molecules are expressed on NK cells in ...
DOI:
10.1007/s00709-016-1016-5

20. BCG immune activation reduces growth and angiogenesis in an in vitro model of head and neck squamous cell carcinoma

Author:
Carolina Sánchez-Rodríguez; Keyliz Peraza Cruces; Juan Riestra Ayora; Eduardo Martín-Sanz; Ricardo Sanz-Fernández
Source:
Vaccine 2017 v.35 no.47 pp. 6395-6403
ISSN:
0264-410X
Subject:
BCG vaccine; CD8-positive T-lymphocytes; adaptive immunity; angiogenesis; angiopoietin-2; antigens; antineoplastic activity; apoptosis; caspase-3; coculture; cytotoxicity; endothelial cells; head; humans; immunosuppression; interferon-gamma; interleukin-6; models; morbidity; neck; patients; squamous cell carcinoma; tumor necrosis factor-alpha; vaccination; vascular endothelial growth factors
Abstract:
... Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers worldwide and is associated with poor survival and significant treatment morbidity. The immune profile in patients with HNSCC is immunosuppressive and presents cytokine-mediated adaptive immune responses, triggered apoptosis of T cells, and alterations in antigen processing machinery. Bacille Calmette-Guerin (BCG) im ...
DOI:
10.1016/j.vaccine.2017.10.008