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1. Agro-economical selection of the best horticultural practices for reducing drought damages of rainfed fig cultivar 'Sabz'

Author:
E. Zare; H. Zare
Source:
Acta horticulturae 2017 no.1173 pp. 389-394
ISSN:
0567-7572
Subject:
Ficus carica; color; cultivars; drought; evapotranspiration; figs; horticulture; horticulturists; licorice; mulches; orchards; ripening; soil water; surveys; tree damage; trees; vegetation; water stress
Abstract:
... Agricultural drought is a temporary condition that occurs for a short period of time due to deficient precipitation on vegetation and prolonged deficiency of soil moisture. This is the result of imbalance between soil moisture and evapotranspiration. The effectiveness of horticultural practices in conserving of soil moisture and reducing of evapotranspiration area has generally been found to be hi ...
DOI:
10.17660/ActaHortic.2017.1173.67

2. Alleviative effect of licorice on copper chloride-induced oxidative stress in the brain: biochemical, histopathological, immunohistochemical, and genotoxic study

Author:
Heba El-Sayed Mostafa; Eman Ahmad Alaa-Eldin; Dalia Abdallah El-Shafei; Nehal S. Abouhashem
Source:
Environmental science and pollution research international 2017 v.24 no.22 pp. 18585-18595
ISSN:
0944-1344
Subject:
DNA damage; adults; antioxidant activity; antioxidants; apoptosis; astrocytes; brain; chlorides; comet assay; copper; cytoplasm; enzyme activity; glutathione; histopathology; immunohistochemistry; licorice; males; malondialdehyde; mutagens; neurons; neurotoxicity; oxidative stress; protective effect; rats; tissues; traditional medicine
Abstract:
... Although copper is an essential micronutrient involved in a variety of biological processes indispensable for sustaining life, it can be toxic when administered in excess. Licorice (Glycyrrhizaglabra) has been used in Chinese folk medicine for the treatment of various disorders. Licorice has the biological capabilities of detoxication, antioxidation, and antiinfection. Here, we test the hypothesis ...
DOI:
10.1007/s11356-017-9503-6

3. Anti-oxidative effects of some dietary supplements on Yellow perch (Perca flavescens) exposed to different physical stressors

Author:
Hiam Elabd; Han-Ping Wang; Adel Shaheen; Hong Yao; Amany Abbass
Source:
Aquaculture reports 2017 v.8 pp. 21-30
ISSN:
2352-5134
Subject:
Astragalus membranaceus; Glycyrrhiza glabra; Perca flavescens; antioxidant activity; dietary supplements; fish; gene expression regulation; heat; histology; histopathology; hypoxia; licorice; liver
Abstract:
... In current study, Yellow perch (P. flavescens) was exposed to common forms of physical stressors and antioxidative effects of dietary incorporated Astragalus membranaceus (AM) and Glycyrrhiza glabra (liquorice) were assessed. To address this, for a four-week five groups of fish (31±1.0g, average weight) received 1, 2, and 3% (w/w) Glycyrrhiza glabra; and 1% G. glabra- A. membranaceus mixture daily ...
DOI:
10.1016/j.aqrep.2017.09.002
CHORUS:
10.1016/j.aqrep.2017.09.002
Chorus Open Access:
10.1016/j.aqrep.2017.09.002

4. Antibacterial and Antiadhesive Activities of Extracts from Edible Plants against Soft Drink Spoilage by Asaia spp.

Author:
Hubert Antolak; Agata Czyzowska; Dorota Kregiel
Source:
Journal of food protection 2017 v.80 no.1 pp. 25-34
ISSN:
0362-028X
Subject:
Asaia bogorensis; Camellia sinensis; Cinnamomum verum; Glycyrrhiza; Sambucus nigra; Urtica dioica; adenosine triphosphate; adhesion; bacteria; bacterial adhesion; bark; catechin; chemical composition; cinnamon; culture media; elderberries; ethanol; flavanones; flowers; food plants; glycosides; green tea; high performance liquid chromatography; kaempferol; leaves; licorice; mass spectrometry; mineral water; phenolic acids; plankton; plant extracts; plate count; polystyrenes; quercetin; soft drinks; spoilage; viability
Abstract:
... This study was conducted to investigate the antibacterial and antiadhesive activities of ethanol extracts from five edible plant parts: cinnamon bark (Cinnamomum zeylanicum), licorice root (Glycyrrhiza radix), nettle leaves (Urtica dioica), green tea leaves (Camellia sinensis), and elderberry flowers (Sambucus nigra). The chemical constituents of the extracts were identified using high-performance ...
DOI:
10.4315/0362-028X.JFP-16-134

5. Antioxidative and anticancer properties of Licochalcone A from licorice

Author:
Xiangrong Chen; Zuojia Liu; Rizeng Meng; Ce Shi; Na Guo
Source:
Journal of ethnopharmacology 2017 v.198 pp. 331-337
ISSN:
0378-8741
Subject:
Western blotting; antineoplastic activity; antioxidant activity; apoptosis; catalase; cell proliferation; cell viability; chalcone; dose response; free radicals; human cell lines; licorice; life cycle assessment; median effective concentration; medicinal plants; mitogen-activated protein kinase; neoplasm cells; neoplasms; oxidation; proteins; signal transduction; superoxide dismutase; traditional medicine
Abstract:
... Licochalcone A (LCA) is a characteristic chalcone that is found in licorice, which is a traditional medicinal plant. In traditional medicine, LCA possesses many potential biological activities, including anti-parasitic, anti-inflammatory and antitumor activities.To determine the antioxidant activity of LCA and, on this basis, to investigate the role of its anticancer activity.To validate the antio ...
DOI:
10.1016/j.jep.2017.01.028

6. Aroma profile of malbec red wines from La Mancha region: Chemical and sensory characterization

Author:
E. Sánchez-Palomo; M. Trujillo; A. García Ruiz; M.A. González Viñas
Source:
Food research international 2017 v.100 pp. 201-208
ISSN:
0963-9969
Subject:
gas chromatography-mass spectrometry; grapes; leather; licorice; odor compounds; odors; red wines; sensory evaluation; solid phase extraction; tobacco
Abstract:
... The aroma of La Mancha Malbec red wines over four consecutive vintages was characterized by chemical and sensory analysis. Solid phase extraction (SPE) and gas chromatography–mass spectrometry (GC–MS) were used to isolate and analyze free volatile compounds. Quantitative Descriptive Sensory Analysis (QDA) was carried out to characterize the sensory aroma profile. A total of 79 free volatile compou ...
DOI:
10.1016/j.foodres.2017.06.036

7. Benign development of cotton with antibacterial activity and metal sorpability through introduction amino triazole moieties and AgNPs in cotton structure pre-treated with periodate

Author:
Amina L. Mohamed; Ahmed G. Hassabo; S. Shaarawy; A. Hebeish
Source:
Carbohydrate polymers 2017 v.178 pp. 251-259
ISSN:
0144-8617
Subject:
cotton; Escherichia coli; nitrogen; sorption; triazoles; models; nanosilver; silver; cellulose; particle size; sorption isotherms; cotton fabric; licorice; metal ions; aldehydes; bacteria; antibacterial properties
Abstract:
... The research work presented herein was undertaken with a view to develop, characterize and highlight modified cotton fabrics that acquire durable antibacterial activity in concomitant with high metal sorption capacity. The development is based on reacting cotton cellulose previously oxidized by sodium periodate-with 4 amino-1,2,4 triazole in presence and absence of silver nano particles (AgNPs). T ...
DOI:
10.1016/j.carbpol.2017.09.024

8. Binding effect of fluorescence labeled glycyrrhetinic acid with GA receptors in hepatocellular carcinoma cells

Author:
Yu-qi Sun; Chun-mei Dai; Yan Zheng; Shu-dan Shi; Hai-yang Hu; Da-wei Chen
Source:
Life sciences 2017 v.188 pp. 186-191
ISSN:
0024-3205
Subject:
Oriental traditional medicine; cytotoxicity; dissociation; fluorescence; hepatocytes; hepatoma; human cell lines; licorice; ligands; neoplasm cells; receptors; synthesis
Abstract:
... Glycyrrhetinic acid (GA) is a natural active component from licorice, which is broadly used in traditional Chinese medicine. Lots of glycyrrhetinic acid receptors (GA-R) are proved to locate on the surface of liver cells. Many reports about the hepatocellular carcinoma (HCC) treatment were dependent on GA modified carriers. However, the reality of GA-R in HCC cells was not clear. In this paper, 18 ...
DOI:
10.1016/j.lfs.2017.07.032

9. Biosynthesis-Based Quantitative Analysis of 151 Secondary Metabolites of Licorice To Differentiate Medicinal Glycyrrhiza Species and Their Hybrids

Author:
Song Wei; Qiao Xue; Chen Kuan; Wang Ying; Ji Shuai; Feng Jin; Li Kai; Lin Yan; Ye Min
Source:
Analytical chemistry 2017 v.89 no.5 pp. 3146-3153
ISSN:
1520-6882
Subject:
DNA barcoding; Glycyrrhiza; bioactive compounds; biochemical pathways; biosynthesis; chalcones; chemotypes; coumarins; females; flavonols; herbal medicines; homozygosity; hybridization; hybrids; internal transcribed spacers; licorice; males; medicinal plants; metabolomics; phenolic compounds; progeny; quality control; quantitative analysis; saponins; secondary metabolites; transcription (genetics)
Abstract:
... Secondary metabolites are usually the bioactive components of medicinal plants. The difference in the secondary metabolisms of closely related plant species and their hybrids has rarely been addressed. In this study, we conducted a holistic secondary metabolomics analysis of three medicinal Glycyrrhiza species (G. uralensis, G. glabra, and G. inflata), which are used as the popular herbal medicine ...
DOI:
10.1021/acs.analchem.6b04919

10. CYP716A179 functions as a triterpene C-28 oxidase in tissue-cultured stolons of Glycyrrhiza uralensis

Author:
Keita Tamura; Hikaru Seki; Hideyuki Suzuki; Mareshige Kojoma; Kazuki Saito; Toshiya Muranaka
Source:
Plant cell reports 2017 v.36 no.3 pp. 437-445
ISSN:
0721-7714
Subject:
Glycyrrhiza uralensis; betulinic acid; biosynthesis; cytochrome P-450; engineering; genetically engineered microorganisms; glycyrrhizin; heterologous gene expression; licorice; lupeol; oleanolic acid; roots; sequence analysis; stolons; tissue culture; ursolic acid
Abstract:
... KEY MESSAGE : CYP716A179, a cytochrome P450 monooxygenase expressed predominantly in tissue-cultured stolons of licorice (Glycyrrhiza uralensis), functions as a triterpene C-28 oxidase in the biosynthesis of oleanolic acid and betulinic acid. Cytochrome P450 monooxygenases (P450s) play key roles in the structural diversification of plant triterpenoids. Among these, the CYP716A subfamily, which fun ...
DOI:
10.1007/s00299-016-2092-x

11. Characterizing dynamic sensory properties of nutritive and nonnutritive sweeteners with temporal check‐all‐that‐apply

Author:
M. Michelle Reyes; John C. Castura; John E. Hayes
Source:
Journal of sensory studies 2017 v.32 no.3 pp. -
ISSN:
0887-8250
Subject:
deglutition; drying; licorice; nonnutritive sweeteners; rapid methods; sensation; sweetness
Abstract:
... Temporal check‐all‐that‐apply (TCATA) is a rapid method where attributes are actively checked and unchecked to track sensations over time, so that the checked words fully describe the sample in any given moment. Here, we characterize the temporal profiles of sweeteners using TCATA. In two experiments, sweeteners were tested in water at concentrations known to elicit weak to moderate sweetness. Bef ...
DOI:
10.1111/joss.12270
PubMed:
29104366
PubMed Central:
PMC5665403

12. Comparative study of microwave-vacuum and vacuum drying on the physicochemical properties and antioxidant capacity of licorice extract powder

Author:
Yuan-hui Li; Yan-nian Li; Hui-ting Li; Ya-ru Qi; Zhen-feng Wu; Ming Yang
Source:
Powder technology 2017 v.320 pp. 540-545
ISSN:
0032-5910
Subject:
Glycyrrhiza; antioxidant activity; flavonoids; hygroscopicity; licorice; powders; vacuum drying; water solubility; Eastern European region; Russia
Abstract:
... Licorice is the dried root of Glycyrrhiza plants, which have long been used as flavourings, sweeteners, demulcents and expectorants in Western countries; as anti-allergic and anti-inflammatory drugs in China and Japan; and as therapeutics for diseases, such as cancers, heart disease and diabetes, in Russia and Eastern Europe. Licorice extract powder is the aqueous extract of licorice. Lycyrrhizic ...
DOI:
10.1016/j.powtec.2017.07.076

13. The Effect of Licorice Protein Fractions on Proliferation and Apoptosis of Gastrointestinal Cancer Cell Lines

Author:
Soheila Khazraei-Moradian; Mazdak Ganjalikhani-Hakemi; Alireza Andalib; Reza Yazdani; Javad Arasteh; Gholam Ali Kardar
Source:
Nutrition and cancer 2017 v.69 no.2 pp. 330-339
ISSN:
1532-7914
Subject:
antineoplastic activity; apoptosis; colorectal neoplasms; cytotoxicity; flow cytometry; gastrointestinal neoplasms; humans; licorice; mice; neoplasm cells; polyacrylamide gel electrophoresis
Abstract:
... Background : Several methods for the treatment of colon cancer have been introduced, but none of them are safe and effective. We planned to evaluate the inhibitory effect of protein extract of licorice root on HT-29 and CT26 cell lines proliferation and apoptosis. Methods : Protein extract of licorice root was prepared in phosphate-buffered solution, and SDS-PAGE was used to isolate its fractions. ...
DOI:
10.1080/01635581.2017.1263347

14. Effects of liquorice extract on the activity and gene expression level of antioxidant enzymes in longissimus dorsi muscle of Tan lamb

Author:
Y.W. Zhang; H.L. Luo; Y.F. Chang; L.J. Jiao; K. Liu
Source:
Small ruminant research 2017 v.154 pp. 23-28
ISSN:
0921-4488
Subject:
catalase; copper; gene expression; genes; glutathione peroxidase; hydrogen peroxide; lambs; licorice; lipid peroxidation; longissimus muscle; males; manganese; messenger RNA; oxygen; superoxide anion; superoxide dismutase; thiobarbituric acid-reactive substances; zinc
Abstract:
... The objective of this study was to investigate the role of liquorice extract (LE) as a dietary antioxidant supplement in the regulation of muscle antioxidant enzyme in lambs. Fifty Tan male lambs were randomly allocated among five groups with LE supplementation at levels of 0, 1000, 2000, 3000 and 4000mg/kg feed, respectively. After 120days of feeding, the lambs were slaughtered and the longissimu ...
DOI:
10.1016/j.smallrumres.2017.06.012

15. Focusing and non-focusing modulation strategies for the improvement of on-line two-dimensional hydrophilic interaction chromatography × reversed phase profiling of complex food samples

Author:
Lidia Montero; Elena Ibáñez; Mariateresa Russo; Luca Rastrelli; Alejandro Cifuentes; Miguel Herrero
Source:
Analytica chimica acta 2017 pp. -
ISSN:
0003-2670
Subject:
analytical chemistry; comprehensive two-dimensional liquid chromatography; food analysis; hydrophilic interaction chromatography; licorice; models; solvents
Abstract:
... Comprehensive two-dimensional liquid chromatography (LC × LC) is ever gaining interest in food analysis, as often, food-related samples are too complex to be analyzed through one-dimensional approaches. The use of hydrophilic interaction chromatography (HILIC) combined with reversed phase (RP) separations has already been demonstrated as a very orthogonal combination, which allows attaining increa ...
DOI:
10.1016/j.aca.2017.07.013

16. Genetic and environmental effect on the growth characteristics and bioactive components of eight-year-old Glycyrrhiza uralensis Fisch

Author:
Xiaosu Miao; Rongxiu Liu; Hongpei Liu; Fulai Yu; Jiyong Wang; Wenquan Wang; Shengli Wei
Source:
Agri Gene 2017 v.3 pp. 57-62
ISSN:
2352-2151
Subject:
Glycyrrhiza uralensis; Oriental traditional medicine; bioactive compounds; environmental impact; genes; glycyrrhizin; licorice; provenance; temperature
Abstract:
... Licorice derived from Glycyrrhiza uralensis Fisch is an important traditional Chinese medicine. The cultivated licorice has gradually replaced the wild licorice, becoming the main source, while its quality is unstable. To explore the influence of genetic and environment on the quality of cultivated licorice, the growth characteristics and the contents of glycyrrhizin and liquiritin of eight-year-o ...
DOI:
10.1016/j.aggene.2016.11.004

17. Glycybridins A–K, Bioactive Phenolic Compounds from Glycyrrhiza glabra

Author:
Li Kai; Ji Shuai; Song Wei; Kuang Yi; Lin Yan; Tang Shunan; Cui Zexu; Qiao Xue; Yu Siwang; Ye Min
Source:
Journal of natural products 2017 v.80 no.2 pp. 334-346
ISSN:
1520-6025
Subject:
Glycyrrhiza glabra; cytotoxicity; herbal medicines; humans; inhibitory concentration 50; licorice; lung neoplasms; neoplasm cells; nitric oxide; nuclear magnetic resonance spectroscopy; phenolic compounds; therapeutics; transcription factor NF-kappa B
Abstract:
... In an attempt to discover bioactive agents from the herbal medicine Glycyrrhiza glabra (widely known as licorice), 11 new phenolic compounds, glycybridins A–K (1–11), along with 47 known phenolics (12–58) were isolated. Their structures were elucidated on the basis of extensive NMR and MS analyses as well as experimental and computed ECD data. According to the clinical therapeutic effects of licor ...
DOI:
10.1021/acs.jnatprod.6b00783

18. Glycyrrhizin inhibits LPS-induced inflammatory mediator production in endometrial epithelial cells

Author:
Xue-rong Wang; Hong-guang Hao; Lan Chu
Source:
Microbial pathogenesis 2017 v.109 pp. 110-113
ISSN:
0882-4010
Subject:
Glycyrrhiza glabra; Toll-like receptor 4; Western blotting; anti-inflammatory activity; endometrium; enzyme-linked immunosorbent assay; epithelial cells; glycyrrhizin; inducible nitric oxide synthase; inflammation; interleukin-1beta; licorice; mice; nitric oxide; rhizomes; roots; signal transduction; transcription factor NF-kappa B; triterpenoids; tumor necrosis factor-alpha; women
Abstract:
... Endometriosis is a continuous inflammation of uterine endometrium that usually affects women of reproductive age. Glycyrrhizin, a triterpene isolated from the roots and rhizomes of licorice (Glycyrrhiza glabra), has been known to have anti-inflammatory effect. The purpose of this study was to investigate the anti-inflammatory effect of glycyrrhizin on LPS-stimulated mouse endometrial epithelial ce ...
DOI:
10.1016/j.micpath.2017.05.032

19. Glycyrrhizin inhibits porcine epidemic diarrhea virus infection and attenuates the proinflammatory responses by inhibition of high mobility group box-1 protein

Author:
Chang-chao Huan; Hua-xia Wang; Xiang-xiang Sheng; Rui Wang; Xin Wang; Xiang Mao
Source:
Archives of virology 2017 v.162 no.6 pp. 1467-1476
ISSN:
0304-8608
Subject:
Porcine epidemic diarrhea virus; Toll-like receptor 4; Western blotting; cytokines; diarrhea; financial economics; glycyrrhizin; inflammation; licorice; messenger RNA; nucleoproteins; pathogenesis; pork industry; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; swine
Abstract:
... Porcine epidemic diarrhea (PED), caused by porcine epidemic diarrhea virus (PEDV) infection, leads to significant economic losses in the swine industry worldwide. In our studies, we found that glycyrrhizin, the major component of licorice root extracts, could moderately inhibit PEDV infection in Vero cells, when analyzed by western blot, qRT-PCR and a plaque formation assay. We also revealed that ...
DOI:
10.1007/s00705-017-3259-7
PubMed:
28175983
PubMed Central:
PMC7086885

20. LC-ESI-MS/MS method for the enantioseparation of six flavanones

Author:
Irena Baranowska; Judyta Hejniak; Sylwia Magiera
Source:
Analytical methods 2017 v.9 no.6 pp. 1018-1030
ISSN:
1759-9679
Subject:
Mentha piperita nothosubsp. piperita; enantiomers; hesperetin; ionization; leaves; licorice; liquid chromatography; monitoring; naringenin; spectrometers; tandem mass spectrometry
Abstract:
... An LC-ESI-MS/MS method enabling the enantioseparation of six flavanones (flavanone, naringenin, hesperetin, eriodictyol, liquiritigenin and pinostrobin) was developed and validated. Separation occurred in gradient mode on a Chiralpak AD-3R column. Detection was performed in positive ionization mode with multiple reaction monitoring (MRM) on a triple quadrupole tandem mass spectrometer equipped wit ...
DOI:
10.1039/c6ay02952c

21. Micropropagation and in vitro elicitation of licorice (Glycyrrhiza spp.)

Author:
Nancy Jaiswal; Yashodhara Verma; Pragati Misra
Source:
In vitro cellular & developmental biology 2017 v.53 no.3 pp. 145-166
ISSN:
1054-5476
Subject:
DNA; Glycyrrhiza; biotransformation; cryopreservation; drugs; elicitors; encapsulation; explants; genetic transformation; germplasm; germplasm evaluation; humidity; in vitro studies; licorice; micropropagation; microsatellite repeats; pH; phytopharmaceuticals; plant growth substances; planting; secondary metabolites; somaclonal variation; temperature
Abstract:
... The Glycyrrhiza genus, in the Fabaceae family, includes numerous medicinal and edible herbs that contain a wide range of phytochemicals which are used pharmaceutically and commercially. Glycyrrhiza spp. are under the threat of overexploitation and depletion; therefore, there is an urgent need for conservation. It is advantageous to develop in vitro techniques not only for propagation, multiplicati ...
DOI:
10.1007/s11627-017-9832-7

22. Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells

Author:
Tae‐Ho Kang; Goo Yoon; In‐A Kang; Ha‐Na Oh; Jung‐Il Chae; Jung‐Hyun Shim
Source:
Phytotherapy research 2017 v.31 no.12 pp. 1858-1867
ISSN:
0951-418X
Subject:
Glycyrrhiza inflata; NAD ADP-ribosyltransferase; Western blotting; antineoplastic activity; antioxidants; apoptosis; cell proliferation; cell transformation assay; death domain receptors; human cell lines; humans; licorice; melanoma; membrane potential; mitochondrial membrane; neoplasm cells; organic compounds; roots; skin neoplasms; squamous cell carcinoma; staining
Abstract:
... Licochalcone B (Lico B), which is normally isolated from the roots of Glycyrrhiza inflata (Chinese Licorice), generally classified into organic compounds including retrochalcones. Potential pharmacological properties of Lico B include anti‐inflammatory, anti‐bacterial, anti‐oxidant, and anti‐cancer activities. However, its biological effects on melanoma and squamous cell carcinoma (SCC) are unknow ...
DOI:
10.1002/ptr.5928

23. New Sweet-Tasting Oleanane-Type Triterpenoid Saponins from “Tugancao” (Derris eriocarpa How)

Author:
Zhang Hong-Xia; Sun Guo; Gu Jian-Long; Du Zhi-Zhi
Source:
Journal of agricultural and food chemistry 2017 v.65 no.11 pp. 2357-2363
ISSN:
1520-5118
Subject:
Derris; body weight; caudal vein; fractionation; humans; licorice; liquid chromatography; mice; sensory evaluation; stems; sucrose; sweet-tasting compounds; sweetness; tandem mass spectrometry; taste; toxicity; triterpenoid saponins; China
Abstract:
... With the aim to investigate the sweet-tasting compounds in Derris eriocarpa How (a substitute for licorice in “Zhuang” and “Dai” ethnopharmacy in Guangxi and Yunnan provinces of China) as well as to ascertain why the stem of D. eriocarpa can be used to substitute for licorice in the sweetness taste aspect, taste sensory-guided fractionation was conducted to isolate sweet constituents from the extr ...
DOI:
10.1021/acs.jafc.7b00137

24. Probing the contractile vacuole as Achilles’ heel of the biotrophic grapevine pathogen Plasmopara viticola

Author:
Viktoria Tröster; Tabea Setzer; Thomas Hirth; Anna Pecina; Andreas Kortekamp; Peter Nick
Source:
Protoplasma 2017 v.254 no.5 pp. 1887-1901
ISSN:
0033-183X
Subject:
Glycyrrhiza uralensis; NAD(P)H oxidase (H2O2-forming); Plasmopara viticola; Vitis; actin; aluminum; binding sites; biological control; confocal microscopy; copper; downy mildew; electron microscopy; extracellular matrix; glycyrrhizin; integrins; ions; licorice; mechanism of action; pathogens; peptides; plant protection; sodium; stomata; vacuoles; viticulture; zoospores
Abstract:
... The causative agent of Grapevine Downy Mildew, the oomycete Plasmopara viticola, poses a serious threat to viticulture. In the current work, the contractile vacuole of the zoospore is analysed as potential target for novel plant protection strategies. Using a combination of electron microscopy, spinning disc confocal microscopy, and video differential interference contrast microscopy, we have foll ...
DOI:
10.1007/s00709-017-1123-y

25. Protective effect of isoliquiritin against corticosterone-induced neurotoxicity in PC12 cells

Author:
Yu-zhi Zhou; Xiao LiXiao Li is the Co-first author.; Wen-xia Gong; Jun-sheng Tian; Xiao-xia Gao; Li Gao; Xiang Zhang; Guan-hua Du; Xue-mei Qin
Source:
Food & function 2017 v.8 no.3 pp. 1235-1244
ISSN:
2042-650X
Subject:
antidepressants; antioxidant activity; apoptosis; calcium; caspase-3; catalase; enzyme activity; flavonoids; glycosides; licorice; malondialdehyde; medicinal properties; membrane potential; mitochondria; mitochondrial membrane; neurotoxicity; oxidative stress; protective effect; protein synthesis; superoxide dismutase; therapeutics
Abstract:
... Isoliquiritin, a flavonoid glycoside compound from licorice, possesses a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory and anti-depression activities. However, the neuroprotective mechanisms of antidepressant effects remain unclear. In this study, the aim was to investigate the cytoprotective efficiency and potential mechanisms of isoliquiritin in corticoste ...
DOI:
10.1039/c6fo01503d

26. Randomized, double‐blinded, placebo‐controlled pilot study on the effects of topical blackcurrant emulsion enriched in essential fatty acids, ceramides and 18‐beta glycyrrhetinic acid on clinical signs and skin barrier function in dogs with atopic dermatitis

Author:
Rosanna Marsella; Luisa Cornegliani; Ibrahim Ozmen; Mary Bohannon; Kim Ahrens; Domenico Santoro
Source:
Veterinary dermatology 2017 v.28 no.6 pp. 577
ISSN:
0959-4493
Subject:
atopic dermatitis; black currants; ceramides; compliance; dogs; emulsions; essential fatty acids; licorice; pruritus; roots; skin lesions; therapeutics; veterinary medicine
Abstract:
... BACKGROUND: Lipid‐based emulsions can be useful for the management of canine atopic dermatitis (cAD). 18‐beta glycyrrhetinic acid (GRA), a component of liquorice root, has anti‐inflammatory and anti‐pruritic effects. HYPOTHESIS/OBJECTIVES: To evaluate the effects of a topical lipid emulsion containing ceramides, fatty acids and GRA on clinical signs of cAD and skin barrier in a randomized, double‐ ...
DOI:
10.1111/vde.12467

27. Regeneration of tert-butylhydroquinone by tea polyphenols

Author:
Yafang Guo; Yahui Guo; Yunfei Xie; Yuliang Cheng; He Qian; Weirong Yao
Source:
Food research international 2017 v.95 pp. 1-8
ISSN:
0963-9969
Subject:
antioxidant activity; antioxidants; electron paramagnetic resonance spectroscopy; food matrix; gelatin; ginger; hydroquinone; licorice; oats; packaging; packaging materials; polyphenols; synergism; tea
Abstract:
... To study the antioxidant capacity (AC) regeneration of tert-butylhydroquinone (TBHQ) by tea polyphenols (TPs), a separable system has been designed for its evaluation. The AC values of three natural food matrices (liquorice, oat, and ginger) and TBHQ regenerated by TPs were all higher than their controls, and similar to the initial values (p<0.05). The average regeneration efficiency (RE) value wa ...
DOI:
10.1016/j.foodres.2017.02.009

28. Research on the modern clinical herbal administration rules in TCM treatment of ovarian cysts based on data mining

Author:
Ya'nan Song; Jianpeng Hu; Haiyan Wang; Lina Wang; Xiaojuan Li; Yun Pan; Feifei Bu; Jian Wang
Source:
Journal of traditional Chinese medical sciences 2017 v.4 no.2 pp. 222-231
ISSN:
2095-7548
Subject:
Angelica sinensis; Manis; Paeonia; Poria; blood circulation; blood stasis; cortex; databases; heart; licorice; liver; peaches; rhizomes; rubber; spleen
Abstract:
... To explore the recent 20 years' herbal administration rules in TCM treatments of ovarian cysts (OCs) based on data mining.A prescription database for ovarian cysts was established by ACCESS 2007. Importing the database into SPSS17.0 and SPSS Modeler14.1. SPSS17.0 was used for descriptive and cluster analyses, while SPSS Modeler14.1 was used for association rules analysis.After screening, 363 presc ...
DOI:
10.1016/j.jtcms.2017.07.005

29. Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury

Author:
Yi Kuang; Yan Lin; Kai Li; Wei Song; Shuai Ji; Xue Qiao; Qingying Zhang; Min Ye
Source:
Phytomedicine 2017 v.34 pp. 59-66
ISSN:
0944-7113
Subject:
Glycyrrhiza uralensis; acetaminophen; active ingredients; carbon tetrachloride; cell viability; chalcones; hepatoprotective effect; human cell lines; licorice; liver; phenolic compounds; screening
Abstract:
... Licorice and its constituents, especially licorice flavonoids have been reported to possess significant hepatoprotective activities. However, previous studies mainly focus on the extract and major compounds, and few reports are available on other licorice compounds.This work aims to evaluate the in vitro hepatoprotective activities of licorice compounds and screen active compounds, and to establis ...
DOI:
10.1016/j.phymed.2017.08.005

30. Study of glycyrrhizic acid contents from Glycyrrhiza glabra populations in Iran and their relation with environmental factors

Author:
SHAGHAYEGH REZAEI; TAHER NEJADSATTARI; MOSTAFA ASSADI; RAMEZAN ALI KHAVARINEJAD; IRAJ MEHREGAN
Source:
Biodiversitas 2017 v.18 no.1 pp. -
ISSN:
2085-4722
Subject:
Glycyrrhiza glabra; calcium carbonate; chemical composition; glycyrrhizin; licorice; morphometry; pH; phosphorus; soil; sucrose; temperature; Iran
Abstract:
... Rezaei S, Nejadsattari T, Assadi M, Khavarinejad RA,Mehregan I. 2017. Study of glycyrrhizic acid contents from Glycyrrhiza glabra populations in Iran and their relation with environmental factors. Biodiversitas 18: 212-220. Glycyrrhizin (glycyrrhizic acid) is an important chemical composition of licorice (Glycyrrhiza glabra L.) from which is 50 times sweeter than sucrose. In this study, the amount ...
DOI:
10.13057/biodiv/d180127

31. Susceptibility testing of Candida albicans and Candida glabrata to Glycyrrhiza glabra L.

Author:
Natália Martins; Sofia Costa-Oliveira; Luís D.R. Melo; Isabel C.F.R. Ferreira; Joana Azeredo; Mariana Henriques; Sónia Silva
Source:
Industrial crops and products 2017 v.108 pp. 480-484
ISSN:
0926-6690
Subject:
Candida albicans; Candida glabrata; Glycyrrhiza glabra; antifungal agents; cell membranes; cytoplasm; drug resistance; flow cytometry; licorice; medicinal plants; membrane potential; methanol; public health; researchers; toxicity; transmission electron microscopy; yeasts
Abstract:
... Medicinal plants and their botanical formulations have gained a pivotal attention among scientific researchers mainly due to its action as health promoters. Licorice (Glycyrrhiza glabra L.) constitutes a great example, with an increasingly evidenced antimicrobial potential. Opportunistic yeast infections constitute an alarming public health problem, highly exacerbated by the inefficacy of antifung ...
DOI:
10.1016/j.indcrop.2017.07.008

32. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review

Author:
Somayeh Nazari; Maryam Rameshrad; Hossein Hosseinzadeh
Source:
Phytotherapy research 2017 v.31 no.11 pp. 1635-1650
ISSN:
0951-418X
Subject:
Glycyrrhiza glabra; adverse effects; anorexia nervosa; carcinogenicity; cytotoxicity; developmental toxicity; enzyme activity; females; gastrointestinal system; genotoxicity; glycyrrhizin; herbal medicines; hypertension; hypokalemia; licorice; mutagenicity; pregnancy; research projects; salts; spices
Abstract:
... Licorice (Glycyrrhiza glabra) has been considered as an herbal drug since ancient time. Nowadays, it is a well‐known spice that possesses worth pharmacological effects. However, some relevant articles have revealed negative impacts of licorice in health. By considering the great wishes in using herbal medicine, it is important to show adverse effects of herbal medicine in health. At present, there ...
DOI:
10.1002/ptr.5893

33. The attenuating effect of aqueous extract of licorice on bleomycin-induced pulmonary fibrosis in mice

Author:
Mehri Ghorashi; Mohammad Ali Rezaee; Mohammad Jafar Rezaie; Mehdi Mohammadi; Ali Jalili; Mohammad Reza Rahmani
Source:
Food and agricultural immunology 2017 v.28 no.1 pp. 67-77
ISSN:
1465-3443
Subject:
collagen; fibrosis; gene overexpression; genes; interleukin-1beta; licorice; lungs; mice; reverse transcriptase polymerase chain reaction; staining; tumor necrosis factor-alpha; weight gain
Abstract:
... Licorice has immunomodulatory and anti-asthmatic properties. This study aims to test the effect of licorice on pulmonary fibrosis (PF). PF was induced in mice through bleomycin instillation. One group of the mice received bleomycin (positive control), another one received phosphate-buffered saline and the other two received 300 mg/kg of the extracts for 20 days after the bleomycin instillation. He ...
DOI:
10.1080/09540105.2016.1203294

34. A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture

Author:
Davide S. Risso; Cristina Giuliani; Marco Antinucci; Gabriella Morini; Paolo Garagnani; Sergio Tofanelli; Donata Luiselli
Source:
Appetite 2017 v.114 pp. 240-247
ISSN:
0195-6663
Subject:
bitterness; broccoli; Europeans; humans; licorice; phenotype; Parmesan cheese; genetic background; health status; receptors; stevioside; taste; food choices; genetic variation; biodiversity; volunteers; beers
Abstract:
... The study of food choice, one of the most complex human traits, requires an integrated approach that takes into account environmental, socio-cultural and biological diversity. We recruited 183 volunteers from four geo-linguistic groups and highly diversified in terms of both genetic background and food habits from whom we collected genotypes and phenotypes tightly linked to taste perception. We co ...
DOI:
10.1016/j.appet.2017.03.046

35. An improved process for the production of highly purified recombinant thaumatin tagged-variants

Author:
Robert D. Healey; Helene Lebhar; Simon Hornung; Pall Thordarson; Christopher P. Marquis
Source:
Food chemistry 2017 v.237 pp. 825-832
ISSN:
0308-8146
Subject:
sequence analysis; Komagataella pastoris; licorice; taste receptors; mouth; tryptophan; molecular chaperones; gel chromatography; chemical bonding; flavor; reversed-phase high performance liquid chromatography; Thaumatococcus daniellii; beverage industry; fluorescence emission spectroscopy; circular dichroism spectroscopy; taste
Abstract:
... The sweetest tasting molecule known is the protein thaumatin, first isolated from the katemfe fruit, Thaumatococcus daniellii. Thaumatin is used in the food and beverage industry as a low-calorie sugar substitute. Thaumatin interacts with taste receptors in the oral cavity eliciting a persistent sweet taste and a bitter, liquorice flavor. Recombinant thaumatin was expressed in Pichia pastoris and ...
DOI:
10.1016/j.foodchem.2017.06.018

36. The licorice dietary component isoliquiritigenin chemosensitizes human uterine sarcoma cells to doxorubicin and inhibits cell growth by inducing apoptosis and autophagy via inhibition of m-TOR signaling

Author:
Li-Chun Lin; Chi-Hao Wu; Tzong-Ming Shieh; Hsin-Yuan Chen; Tsui-Chin Huang; Shih-Min Hsia
Source:
Journal of functional foods 2017 v.33 pp. 332-344
ISSN:
1756-4646
Subject:
NAD ADP-ribosyltransferase; adverse effects; antineoplastic activity; apoptosis; autophagy; cell growth; chalcone; doxorubicin; drug therapy; flow cytometry; human cell lines; humans; licorice; multiple drug resistance; necrosis; neoplasm cells; protein synthesis; rapamycin; sarcoma; uterine neoplasms
Abstract:
... Uterine sarcoma is a rare gynecologic cancer. Doxorubicin (Dox) is widely used for treating several cancers, including uterine sarcoma. However, multidrug resistance is a major clinical problem and a critical cause of treatment failure. Strategies for increasing chemosensitivity and reducing the dose of chemotherapeutic agents should be established to prevent drug side effects, and the development ...
DOI:
10.1016/j.jff.2017.03.061

37. A new exploration of licorice metabolome

Author:
Giovanni Rizzato; Elisa Scalabrin; Marta Radaelli; Gabriele Capodaglio; Oreste Piccolo
Source:
Food chemistry 2017 v.221 pp. 959-968
ISSN:
0308-8146
Subject:
Glycyrrhiza; chemical composition; flavorings; licorice; mass spectrometry; metabolites; metabolome; metabolomics; rhizomes; roots; statistical analysis; sweets; tobacco
Abstract:
... The roots and rhizomes of licorice plants (genus Glycyrrhiza L.) are commercially employed, after processing, in confectionery production or as sweetening and flavouring agents in the food, tobacco and beer industries. G. glabra, G. inflata and G. uralensis are the most significant licorice species, often indistinctly used for different productions. Licorice properties are directly related to its ...
DOI:
10.1016/j.foodchem.2016.11.068

38. AMPK activation by liquiritigenin inhibited oxidative hepatic injury and mitochondrial dysfunction induced by nutrition deprivation as mediated with induction of farnesoid X receptor

Author:
Eun Hye Jung; Ju-Hee Lee; Sang Chan Kim; Young Woo Kim
Source:
European journal of nutrition 2017 v.56 no.2 pp. 635-647
ISSN:
1436-6207
Subject:
AMP-activated protein kinase; NAD ADP-ribosyltransferase; apoptosis; blood serum; cell viability; flavonoids; flow cytometry; gene expression; glutathione; hepatocytes; human cell lines; licorice; ligands; liver; messenger RNA; metformin; mice; mitochondria; oxidative stress; phosphorylation; proteins; starvation
Abstract:
... PURPOSE: Nutrition is indispensable for cell survival and proliferation. Thus, loss of nutrition caused by serum starvation in cells could induce formation of reactive oxygen species (ROS), resulting in cell death. Liquiritigenin (LQ) is an active flavonoid in licorice and plays a role in the liver as a hepatic protectant. METHODS: This study investigated the effect of LQ, metformin [an activator ...
DOI:
10.1007/s00394-015-1107-7

39. Characterization of the Key Aroma Compounds in Heat-Processed Licorice (Succus Liquiritiae) by Means of Molecular Sensory Science

Author:
Wagner Juliane; Schieberle Peter; Granvogl Michael
Source:
Journal of agricultural and food chemistry 2017 v.65 no.1 pp. 132-138
ISSN:
1520-5118
Subject:
cineole; flavor compounds; isotope dilution technique; licorice; models; odor compounds; odors; stable isotopes; sucrose; vanillin
Abstract:
... Application of the sensomics concept elucidated the key odorants of heat-processed licorice (Succus Liquiritiae). Forty-nine aroma-active compounds with flavor dilution (FD) factors between 16 and 2048 were detected; 47 thereof were identified, 23 for the first time in heated licorice. 4-Hydroxy-2,5-dimethylfuran-3(2H)-one revealed the highest FD factor of 2048, followed by 3-hydroxy-4,5-dimethylf ...
DOI:
10.1021/acs.jafc.6b04499

40. Comparative metabolomics analysis for the compatibility and incompatibility of kansui and licorice with different ratios by UHPLC-QTOF/MS and multivariate data analysis

Author:
Juan Shen; Zong-Jin Pu; Jun Kai; An Kang; Yu-Ping Tang; Li-Li Shang; Gui-Sheng Zhou; Zhen-Hua Zhu; Er-Xin Shang; Shao-Ping Li; Yu-Jie Cao; Wei-Wei Tao; Shu-Lan Su; Li Zhang; Huiping Zhou; Da-Wei Qian; Jin-Ao Duan
Source:
Journal of chromatography 2017 v.1057 pp. 40-45
ISSN:
1570-0232
Subject:
Euphorbia kansui; metabolism; nicotinamide; urine; biomarkers; models; least squares; biochemical pathways; seleno amino acids; ultra-performance liquid chromatography; toxicity; licorice; mass spectrometry; metabolomics; Oriental traditional medicine; rats
Abstract:
... Kansui, the root of Euphorbia kansui T.N. Liou ex T.P. Wang (Euphorbiaceae), is a well-known poisonous traditional Chinese medicine (TCM). However, many monographs of TCM indicated that it cannot be co-used with licorice, as kansui-licorice is a typical “eighteen incompatible” medicaments. Our previous studies have indicated that kansui was effective in treating malignant pleural effusion (MPE), a ...
DOI:
10.1016/j.jchromb.2017.04.042

41. Determination of biogenic amines in licorice (Glycyrrhiza glabra) by ion‐pair extraction and liquid chromatography–tandem mass spectrometry

Author:
Şevket Ata; Mehmet Akyüz; Hasan Çabuk
Source:
Journal of the science of food and agriculture 2017 v.97 no.5 pp. 1427-1432
ISSN:
0022-5142
Subject:
Glycyrrhiza glabra; agmatine; cadaverine; detection limit; histamine; licorice; liquid chromatography; putrescine; quantitative analysis; spermidine; spermine; statistical analysis; tandem mass spectrometry; tryptamine; tyramine
Abstract:
... BACKGROUND: Ion‐pair extraction combined with liquid chromatography–tandem mass spectrometry method has been proposed for the determination of biogenic amines in licorice samples. RESULTS: Limit of detection and limit of quantitation for the biogenic amines were 1.4–2.7 and 4.7–9.1 ng mL⁻¹, respectively. Relative standard deviations based on five replicate extraction of 100 ng mL⁻¹ of each biogeni ...
DOI:
10.1002/jsfa.7881

42. Draft genome assembly and annotation of Glycyrrhiza uralensis, a medicinal legume

Author:
Keiichi Mochida; Tetsuya Sakurai; Hikaru Seki; Takuhiro Yoshida; Kotaro Takahagi; Satoru Sawai; Hiroshi Uchiyama; Toshiya Muranaka; Kazuki Saito
Source:
plant journal 2017 v.89 no.2 pp. 181-194
ISSN:
0960-7412
Subject:
Glycyrrhiza uralensis; Medicago; bioactive compounds; biosynthesis; breeding; chickpeas; gene expression; genes; genome assembly; herbal medicines; licorice; loci; rhizomes; roots; synthetic biology; triterpenoid saponins
Abstract:
... Chinese liquorice/licorice (Glycyrrhiza uralensis) is a leguminous plant species whose roots and rhizomes have been widely used as a herbal medicine and natural sweetener. Whole‐genome sequencing is essential for gene discovery studies and molecular breeding in liquorice. Here, we report a draft assembly of the approximately 379‐Mb whole‐genome sequence of strain 308‐19 of G. uralensis; this assem ...
DOI:
10.1111/tpj.13385

43. Effects of Composite Natural Antioxidants on the Fat Oxidation, Textural and Sensory Properties of Cantonese Sausages during Storage

Author:
Xiaofang Zeng; Weidong Bai; Changhai Lu; Hao Dong
Source:
Journal of food processing and preservation 2017 v.41 no.2 pp. -
ISSN:
0145-8892
Subject:
acidity; antioxidants; free fatty acids; ginger; licorice; lipid metabolism; meat; peroxide value; potassium hydroxide; rosemary; sausages; sensory properties; storage time; thiobarbituric acid-reactive substances; vitamin E
Abstract:
... Effects of composite natural antioxidants on the fat oxidation, textural and sensory properties of Cantonese sausage were investigated. Results indicated that Cantonese sausages with composite natural antioxidants obtained lower acidity value (AV), peroxide value (POV), 2‐thiobarbituric acid‐reactive substances (TBARs) and total free fatty acids (TFFA) compared to the controls, indicating that the ...
DOI:
10.1111/jfpp.13010

44. Glycycoumarin prevents hepatic steatosis through activation of adenosine 5,-monophosphate (AMP)-activated protein kinase signaling pathway and up-regulation of BTG1/Tob-1

Author:
Enxiang Zhang; Xinhua Song; Shutao Yin; Lihong Fan; Min Ye; Hongbo Hu
Source:
Journal of functional foods 2017 v.34 pp. 277-286
ISSN:
1756-4646
Subject:
AMP-activated protein kinase; animal models; beta oxidation; cell culture; coumarin; diet; droplets; fatty liver; licorice; lipogenesis; oleic acid; palmitates; protective effect; signal transduction
Abstract:
... Glycycoumarin (GCM) is a representative of coumarin compounds isolated from licorice, a popular herbal plant which is widely used to treat various diseases including liver diseases. This study was designed to evaluate the protective effects of GCM on hepatic steatosis in the setting of non-alcoholic fatty liver disease using both cell culture model of OA(oleic acid)/PA(palmitate acid)-induced lipi ...
DOI:
10.1016/j.jff.2017.04.036

45. Hepatic metabolism of licochalcone A, a potential chemopreventive chalcone from licorice (Glycyrrhiza inflata), determined using liquid chromatography-tandem mass spectrometry

Author:
Lingyi Huang; Dejan Nikolic; Richard B. van Breemen
Source:
Analytical and bioanalytical chemistry 2017 v.409 no.30 pp. 6937-6948
ISSN:
1618-2642
Subject:
Glycyrrhiza inflata; catechol; chalcone; chemoprevention; cytochrome P-450; enzymes; epoxidation reactions; glucuronic acid; glutathione; hepatocytes; humans; licorice; liquid chromatography; liver microsomes; metabolism; metabolites; methylation; nuclear magnetic resonance spectroscopy; sulfates; tandem mass spectrometry
Abstract:
... The metabolism of the chemoprevention agent licochalcone A, which is a chemopreventive chalcone found in abundance in the licorice species Glycyrrhiza inflata, was investigated using human liver microsomes and human hepatocytes combined with analysis using high performance liquid chromatography-mass spectrometry (LC-MS). Five oxygenated phase I metabolites of licochalcone A were formed by human li ...
DOI:
10.1007/s00216-017-0642-x
PubMed:
29127460
PubMed Central:
PMC6324850

46. Isoliquiritigenin attenuates MiR-21 expression via induction of PIAS3 in breast cancer cells

Author:
Shilong Ning; Xiao Ma; Dongmei Zhu; Zhaoxia Shen; Jiao Liu; Yun Liu; Juan Chen; Zhong Li
Source:
RSC advances 2017 v.7 no.29 pp. 18085-18092
ISSN:
2046-2069
Subject:
breast neoplasms; dose response; licorice; luciferase; neoplasm cells; signal transduction; small interfering RNA; transactivators; transcription (genetics); transfection
Abstract:
... We have previously documented that isoliquiritigenin (ISL), a dietary compound extracted from licorice, could exert anti-breast cancer effects via inhibition of miR-21, however, the intrinsic mechanisms remain obscure. Herein, we discovered that ISL down-regulated the primary miR-21 (pri-miR-21) and mature miR-21 expression in a dose-dependent manner, indicating transcriptional silencing of miR-21 ...
DOI:
10.1039/c6ra25511f

47. Licorice extract attenuates brain aging of d-galactose induced rats through inhibition of oxidative stress and attenuation of neuronal apoptosis

Author:
Yu-Zhi Zhou; Fan-Fan Zhao; Li Gao; Guan-Hua Du; Xiang Zhang; Xue-Mei Qin
Source:
RSC advances 2017 v.7 no.75 pp. 47758-47766
ISSN:
2046-2069
Subject:
Western blotting; apoptosis; caspase-3; cognition; eosin; galactose; glutathione peroxidase; hippocampus; intraperitoneal injection; licorice; medicinal properties; memory; neurons; oxidative stress; protective effect; rats; staining; superoxide dismutase
Abstract:
... Licorice, an edible and officinal plant, has attracted considerable attention for its wide range of pharmacological activities. The present study focused on the protective effect of licorice on aging rats and on exploring its potential mechanisms. Aging in rats was induced by d-gal (300 mg kg⁻¹) for 5 weeks continuously with intraperitoneal injection, while control rats received physiological sali ...
DOI:
10.1039/c7ra07110h

48. Liquiritin, a flavone compound from licorice, inhibits IL-1β-induced inflammatory responses in SW982 human synovial cells

Author:
Yao-Xin Gao; Bin-Feng Cheng; Jun-Jiang Lian; Dan-Dan Guo; Jing-Wen Qin; Yong-Bo Zhang; Hai-Jie Yang; Mian Wang; Lei Wang; Zhi-Wei Feng
Source:
Journal of functional foods 2017 v.33 pp. 142-148
ISSN:
1756-4646
Subject:
AMP-activated protein kinase; anti-inflammatory activity; foods; human cell lines; humans; inflammation; interleukin-1beta; interleukin-6; interleukin-8; licorice; messenger RNA; mitogen-activated protein kinase; phosphorylation; protein transport; rheumatoid arthritis; transcription factor NF-kappa B
Abstract:
... Liquiritin is one of flavone compounds derived from licorice, a common flavoring and sweetening agent in food products. This study investigated the effects and mechanisms of liquiritin in interleukin (IL)-1β-stimulated SW982 human synovial cells, which is a useful tool to study the inflammatory response of rheumatoid arthritis (RA). The SW982 cells were pretreated with various concentrations (0, 1 ...
DOI:
10.1016/j.jff.2017.03.039

49. Perspective on Biotransformation and De Novo Biosynthesis of Licorice Constituents

Author:
Yujia Zhao; Bo Lv; Xudong Feng; Chun Li
Source:
Journal of agricultural and food chemistry 2017 v.65 no.51 pp. 11147-11156
ISSN:
1520-5118
Subject:
Glycyrrhiza; bioactive compounds; biocatalysts; bioengineering; biosynthesis; biotransformation; cosmetics; ecology; economic valuation; herbal medicines; industry; licorice; microorganisms; rhizomes; roots; tobacco
Abstract:
... Licorice, an important herbal medicine, is derived from the dried roots and rhizomes of Glycyrrhiza genus plants. It has been widely used in food, pharmaceutical, tobacco, and cosmetics industries with high economic value. However, overexploitation of licorice resources has severely destroyed the local ecology. Therefore, producing bioactive compounds of licorice through the biotransformation and ...
DOI:
10.1021/acs.jafc.7b04470

50. Purification of high-purity glycyrrhizin from licorice using hydrophilic interaction solid phase extraction coupled with preparative reversed-phase liquid chromatography

Author:
Wenyi Yu; Hongli Jin; Aijin Shen; Liang Deng; Jianlian Shi; Xingya Xue; Yadong Guo; Yanfang Liu; Xinmiao Liang
Source:
Journal of chromatography 2017 v.1040 pp. 47-52
ISSN:
1570-0232
Subject:
bioactive compounds; dermatitis; flavonoids; glycyrrhizin; hydrophilic interaction chromatography; hydrophilicity; ion exchange; ionic strength; licorice; pH; reversed-phase liquid chromatography; salt concentration; solid phase extraction; viral hepatitis; water content
Abstract:
... Glycyrrhizin (GA), a major bioactive compound in licorice, has been extensively used throughout the world as a medicine to treat chronic viral hepatitis and allergic dermatitis. In this study, a new method based on hydrophilic interaction solid phase extraction (HILIC-SPE) and preparative reversed-phase liquid chromatography (prep-RPLC) was developed to purify GA with high purity from the complex ...
DOI:
10.1016/j.jchromb.2016.11.031

51. UPLC/ESI-QTOF-MS-based metabolomics survey on the toxicity of triptolide and detoxication of licorice

Author:
Zhuo WANG; Jian-Qun LIU; Jin-Di XU; He ZHU; Ming KONG; Guo-Hua ZHANG; Su-Min DUAN; Xiu-Yang LI; Guang-Fu LI; Li-Fang LIU; Song-Lin LI
Source:
Chinese journal of natural medicines 2017 v.15 no.6 pp. 474-480
ISSN:
1875-5364
Subject:
Oriental traditional medicine; Tripterygium wilfordii; adverse effects; antineoplastic activity; biomarkers; exposure duration; immunosuppression; licorice; metabolism; metabolites; metabolomics; pantothenic acid; porphyrins; principal component analysis; rats; rheumatoid arthritis; surveys; therapeutics; toxicity; tryptophan; urine
Abstract:
... Triptolide (TP) from Tripterygium wilfordii has been demonstrated to possess anti-inflammatory, immunosuppressive, and anticancer activities. TP is specially used for the treatment of awkward rheumatoid arthritis, but its clinical application is confined by intense side effects. It is reported that licorice can obviously reduce the toxicity of TP, but the detailed mechanisms involved have not been ...
DOI:
10.1016/S1875-5364(17)30071-7

52. The anti-inflammatory activity of licorice, a widely used Chinese herb

Author:
Rui Yang; Bo-Chuan Yuan; Yong-Sheng Ma; Shan Zhou; Ying Liu
Source:
Pharmaceutical biology 2017 v.55 no.1 pp. 5-18
ISSN:
1744-5116
Subject:
adverse effects; anti-inflammatory activity; clinical trials; digestive system; drugs; flavonoids; free radicals; in vitro studies; licorice; maximum tolerated dose; models; pain; pharmacokinetics; triterpenoids; tumor necrosis factors; China
Abstract:
... Context: Increasing incidence and impact of inflammatory diseases have encouraged the search of new pharmacological strategies to face them. Licorice has been used to treat inflammatory diseases since ancient times in China. Objective: To summarize the current knowledge on anti-inflammatory properties and mechanisms of compounds isolated from licorice, to introduce the traditional use, modern clin ...
DOI:
10.1080/13880209.2016.1225775
PubMed:
27650551
PubMed Central:
PMC7012004

53. The complete chloroplast genome sequence of Glycyrrhiza lepidota (Nutt.) Pursh - An American wild licorice

Author:
Sebastin Raveendar; Yoon-Sup So; Kyung Jun Lee; Dong-Jin Lee; Jwakyung Sung; Jong-Wook Chung
Source:
Journal of crop science and biotechnology 2017 v.20 no.4 pp. 295-303
ISSN:
1975-9479
Subject:
Glycyrrhiza glabra; Glycyrrhiza lepidota; chloroplast genome; chloroplasts; food crops; gene pool; genes; legumes; licorice; microsatellite repeats; phylogeny; ribosomal RNA; transfer RNA
Abstract:
... The wild species are considered as primary and secondary genepools for the world’s most important food crops. Here, we sequenced the complete chloroplast (cp) genome sequence of an American wild licorice, Glycyrrhiza lepidota for the first time to investigate their phylogenetic relationship among inverted-repeat-lacking clade (IRLC) legumes. The total length of the chloroplast genome is 127,939 bp ...
DOI:
10.1007/s12892-017-0137-0

54. The effects of licorice flavonoid oil with respect to increasing muscle mass: a randomized, double‐blind, placebo‐controlled trial

Author:
Tetsu Kinoshita; Akio Matsumoto; Kazuhiro Yoshino; Shinya Furukawa
Source:
Journal of the science of food and agriculture 2017 v.97 no.8 pp. 2339-2345
ISSN:
0022-5142
Subject:
elderly; flavonoids; licorice; men; muscles; oils; osteoarthritis; placebos; women
Abstract:
... BACKGROUND: The present study evaluated the effects of licorice flavonoid oil (LFO) with respect to increasing the muscle mass of elderly populations using a randomized, double‐blind, placebo‐controlled study. Fifty participants aged 54–90 years (seven men, 43 women), who underwent rehabilitation treatment for osteoarthritis of the knee, were examined and assigned to either the LFO group (n = 26) ...
DOI:
10.1002/jsfa.8044

55. iTRAQ-based quantitative proteomic analysis reveals Bai-Hu-Tang enhances phagocytosis and cross-presentation against LPS fever in rabbit

Author:
Shidong Zhang; Dongsheng Wang; Shuwei Dong; Zhiqiang Yang; Zuoting Yan
Source:
Journal of ethnopharmacology 2017 v.207 pp. 1-7
ISSN:
0378-8741
Subject:
Anemarrhena; actin; bioinformatics; body weight; butylated hydroxytoluene; fever; gene expression regulation; gene ontology; gypsum; licorice; lipopolysaccharides; liquid chromatography; liver; major histocompatibility complex; models; phagocytosis; phagosomes; protein content; protein synthesis; proteomics; rabbits; rhizomes; ribosomes; rice; structural proteins; tandem mass spectrometry; thirst; traditional medicine
Abstract:
... Bai-Hu-Tang (BHT), a classical anti-febrile Chinese formula comprising of liquorice, anemarrhena rhizome, gypsum and rice, has been traditionally used to anti-febrile treatment and promote the production of body fluid to relieve thirst. In this paper, we aim to explore anti-febrile mechanism of BHT at protein level through analyzing alteration of differentially expressed proteins (DEPs) both lipop ...
DOI:
10.1016/j.jep.2017.05.022

56. The immunomodulatory activities of licorice polysaccharides (Glycyrrhiza uralensis Fisch.) in CT 26 tumor-bearing mice

Author:
Peter Amwoga Ayeka; YuHong Bian; Peter Mwitari Githaiga; Ying Zhao
Source:
BMC complementary and alternative medicine 2017 v.17 no.1 pp. 536
ISSN:
1472-6882
Subject:
Glycyrrhiza uralensis; Oriental traditional medicine; T-lymphocytes; alternative medicine; antineoplastic activity; blood serum; carcinogenesis; chemokines; diet; flow cytometry; immunomodulation; immunomodulators; ingredients; licorice; mechanism of action; mice; molecular weight; neoplasms; polysaccharides; spleen; thymus gland; tissue weight; tumor necrosis factor-alpha
Abstract:
... BACKGROUND: The increasing use of complementary and alternative medicine (CAM) has kindled the need for scientific evaluation of the mechanism of action of CAMs. Although, licorice, a common ingredient in many Traditional Chinese medicine (TCM) has attracted great attention for its antitumor and immunomodulatory activities, the mechanism of action of its polysaccharides is still unclear. Here we r ...
DOI:
10.1186/s12906-017-2030-7
PubMed:
29246138
PubMed Central:
PMC5732493