Publication Year: 2017 / Subject term: lignans / Text Availability: Citation in PubAg

1. (-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1

Author:: Di Yang; Chen-Xi Xiao; Zheng-Hua Su; Meng-Wei Huang; Ming Qin; Wei-Jun Wu; Wan-Wan Jia; Yi-Zhun Zhu; Jin-Feng Hu; Xin-Hua Liu
Source:: Phytomedicine 2017 v.32 pp. 15-23
ISSN:: 0944-7113
Subject:: Western blotting; anti-inflammatory activity; antineoplastic activity; antioxidants; cardiovascular diseases; drugs; endothelial cells; fluorescent antibody technique; gene expression regulation; heme oxygenase (biliverdin-producing); inducible nitric oxide synthase; inflammation; interleukin-6; lignans; messenger RNA; mitogen-activated protein kinase; necrosis; pathogenesis; phosphorylation; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; superoxide dismutase; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Endothelial inflammation is an increasingly prevalent condition in the pathogenesis of many cardiovascular diseases. (-)-7(S)-hydroxymatairesinol (7-HMR), a naturally occurring plant lignan, possesses both antioxidant and anti-cancer properties and therefore would be a good strategy to suppress tumor necrosis factor-α (TNF-α)-mediated inflammation in vascular endothelial cells (VECs).: The objecti ...
DOI:: 10.1016/j.phymed.2017.04.005
: https://doi.org/10.1016/j.phymed.2017.04.005

2. Absorption, distribution, metabolism, and excretion of [14C]sesamin in rats

Author:: Namino Tomimori; Tomohiro Rogi; Hiroshi Shibata
Source:: Molecular nutrition & food research 2017 v.61 no.8 pp. -
ISSN:: 1613-4125
Subject:: absorption; autoradiography; bile; carbon; cytochrome P-450; excretion; feces; half life; intestinal microorganisms; kidneys; lignans; liver; metabolites; oral administration; pharmacokinetics; radioactivity; radionuclides; rats; sesame seed; tissue distribution; urine
Abstract:: ... SCOPE: Sesamin is a major lignan in sesame seeds and has various physiological effects. Although metabolism of sesamin by cytochrome P450 or intestinal microflora has been reported, little is known concerning the mass balance, pharmacokinetics, and tissue distribution of sesamin. METHODS AND RESULTS: Absorption, distribution, metabolism, and excretion of [¹⁴C]sesamin were investigated after a sing ...
DOI:: 10.1002/mnfr.201600844
: https://doi.org/10.1002/mnfr.201600844

3. Alashinols F and G, two lignans from stem bark of Syringa pinnatifolia

Author:: Xiao Feng; Guozhu Su; Yunyun Ye; Ruifei Zhang; Xinyao Yang; Bingzhao Du; Bing Peng; Pengfei Tu; Xingyun Chai
Source:: Natural product research 2017 v.31 no.13 pp. 1555-1560
ISSN:: 1478-6427
Subject:: Syringa; anti-inflammatory activity; bark; lignans; nuclear magnetic resonance spectroscopy; spectral analysis; traditional medicine
Abstract:: ... Two new lignans, alashinols F and G (1 and 2), together with two known analogues (−)-secoisolariciresinol (3) and meso -secoisolariciresinol (4) were isolated from the stem bark of Syringa pinnatifolia , a Mongolian folk medicine with anti-myocardial ischaemic effects. Their structures were elucidated on basis of spectroscopic data analyses, including MS and 1D and 2D NMR, and their absolute confi ...
DOI:: 10.1080/14786419.2017.1283500
: https://doi.org/10.1080/14786419.2017.1283500

4. Almond Polyphenols: Methods of Analysis, Contribution to Food Quality, and Health Promotion

Author:: Bradley W. Bolling
Source:: Comprehensive reviews in food science and food safety 2017 v.16 no.3 pp. 346-368
ISSN:: 1541-4337
Subject:: aldehydes; almonds; antioxidant activity; antioxidants; antiviral properties; astringency; blanching; food quality; health promotion; hydrolysis; ingredients; isoflavones; lignans; lipid composition; lipid peroxidation; pasteurization; pigmentation; proanthocyanidins; roasting; shelf life; solvents; stilbenes; tannins; ultraviolet radiation; vitamin E
Abstract:: ... Almond is a nutrient‐dense tree nut recognized for its favorable lipid profile, vitamin E content, and polyphenols. The objectives of this review were to determine the polyphenols reported in almond, summarize the methods of analysis, and determine the polyphenol contribution to almond quality and health‐promoting activity. Approximately 130 different polyphenols have been identified in almond, al ...
DOI:: 10.1111/1541-4337.12260
: https://doi.org/10.1111/1541-4337.12260

5. Anti-biofilm activity against Staphylococcus aureus MRSA and MSSA of neolignans and extract of Piper regnellii

Author:: Lara Z.S. Brambilla; Eliana H. Endo; Diógenes A.G. Cortez; Benedito P. Dias Filho
Source:: Revista Brasileira de Farmacognosia 2017 v.27 no.1 pp. 112-117
ISSN:: 0102-695X
Subject:: Piper; antibiotic resistance; antimicrobial properties; biofilm; disease control; lignans; methicillin; methicillin-resistant Staphylococcus aureus; methylene chloride; minimum inhibitory concentration; plankton
Abstract:: ... Many infections worldwide are associated with bacterial biofilms. The effects of isolated neolignans (conocarpan and eupomathenoid-5) and the dichloromethane extract of Piper regnellii (Miq.) C. DC., Piperaceae, were tested against isolates of methicillin-resistant Staphylococcus aureus and methicillin-sensitive S. aureus biofilms and S. aureus planktonic cells. The dichloromethane extract present ...
DOI:: 10.1016/j.bjp.2016.08.008
: https://doi.org/10.1016/j.bjp.2016.08.008

6. Anti-complementary constituents of Anchusa italica

Author:: Yu-zhen Hou; Kui-kui Chen; Xi-ling Deng; Ze-long Fu; Dao-feng Chen; Qi Wang
Source:: Natural product research 2017 v.31 no.21 pp. 2572-2574
ISSN:: 1478-6427
Subject:: Anchusa azurea; alcohols; alkaloids; complement; flavonoids; fractionation; lignans; triterpenoids
Abstract:: ... Activity-guided fractionation for complement inhibitors led to the isolation of 24 known compounds from Anchusa italica . Chemical types include eight megastigmane compounds, five triterpenoid compounds, five lignan compounds, three flavonoid compounds, two alkaloid compounds and one phenthyl alcohol compound. Among which, a lignan (medioresinol), an alkaloid (5-hydroxypyrrolidin-2-one) and a flav ...
DOI:: 10.1080/14786419.2017.1320789
: https://doi.org/10.1080/14786419.2017.1320789

7. Anti-inflammatory effects of Forsythia suspensa in dextran sulfate sodium-induced colitis

Author:: Youn-Hwan Hwang; Dong-Gun Kim; Wei Li; Hye Jin Yang; Nam-Hui Yim; Jin Yeul Ma
Source:: Journal of ethnopharmacology 2017 v.206 pp. 73-77
ISSN:: 0378-8741
Subject:: Forsythia suspensa; Oriental traditional medicine; anti-inflammatory activity; body weight changes; colitis; colon; dextran sulfate; diarrhea; edema; epithelium; flavonoids; histopathology; inflammation; interleukin-6; lignans; necrosis; therapeutics; triterpenoids; tumor necrosis factor-alpha
Abstract:: ... Forsythia suspensa Fructus (FS) is used to treat various inflammatory disorders in traditional Oriental medicine, including gastrointestinal diseases, but its therapeutic potential in ulcerative colitis is unclear. Thus, we investigated any potential therapeutic effects of FS against intestinal inflammation and the bioactive constituents in FS.After the induction of colitis using 3% dextran sulfat ...
DOI:: 10.1016/j.jep.2017.05.011
: https://doi.org/10.1016/j.jep.2017.05.011

8. Anti-inflammatory neolignans from Epimedium pseudowushanese

Author:: Huihui Ti; Ping Wu; Liangxiong Xu; Xiaoyi Wei
Source:: Natural product research 2017 v.31 no.22 pp. 2621-2628
ISSN:: 1478-6427
Subject:: Epimedium; anti-inflammatory activity; lignans; secretion; spectroscopy; tumor necrosis factor-alpha
Abstract:: ... One new 8- O -4′ neolignan has been isolated from Epimedium pseudowushanese B. L. Guo, together with nine other known neolignans. The structures of these neolignans were elucidated using spectroscopic and chemical techniques, and their anti-inflammatory activities were also evaluated. The results of these experiments revealed that compound 6 was the most potent of the 10 different compounds tested ...
DOI:: 10.1080/14786419.2017.1289200
: https://doi.org/10.1080/14786419.2017.1289200

9. Anti-neuroinflammatory asarone derivatives from the rhizomes of Acorus tatarinowii

Author:: Da-Peng Qin; Xiao-Lin Feng; Wei-Yang Zhang; Hao Gao; Xiao-Rui Cheng; Wen-Xia Zhou; Yang Yu; Xin-Sheng Yao
Source:: RSC advances 2017 v.7 no.14 pp. 8512-8520
ISSN:: 2046-2069
Subject:: Acorus gramineus; X-ray diffraction; cell lines; cytotoxicity; enantiomers; lignans; mice; neuroglia; rhizomes; spectroscopy; tumor necrosis factor-alpha
Abstract:: ... A novel 7-O-7′ type mesomeric neolignan, meso-asarolignan A (1), six pairs of new neolignan enantiomers, (±)-asarolignan B–G (2a/2b, 3a/3b, 4–6, 7a/7b), along with 16 known analogues (8–23) were isolated from the rhizomes of Acorus tatarinowii. The structures of the new compounds were elucidated by extensive analysis of spectroscopic, X-ray diffraction, and computational data. Compounds 1–3 repres ...
DOI:: 10.1039/c6ra27786a
: https://doi.org/10.1039/c6ra27786a

10. Antibacterial neolignans from the leaves of Melaleuca bracteata

Author:: Can Li; Hongxin Liu; Liyun Zhao; Weimin Zhang; Shengxiang Qiu; Xiaoyun Yang; Haibo Tan
Source:: Fitoterapia 2017 v.120 pp. 171-176
ISSN:: 0367-326X
Subject:: Melaleuca; aldehydes; antibiotic resistance; antimicrobial properties; biochemical pathways; biomimetics; leaves; lignans; methicillin; methicillin-resistant Staphylococcus aureus; odors; spectral analysis
Abstract:: ... Phytochemical study on the leaves of Melaleuca bracteata resulted in the isolation of ten compounds including three new neolignans, named melaleucins A–C (1–3). Among them, melaleucin B shares a rarely occurring nor-neolignan skeleton, and both melaleucins B and C bear a novel aldehyde moiety, which might also be response for the delicate fragrance of M. bracteata. Their structures were extensivel ...
DOI:: 10.1016/j.fitote.2017.06.015
: https://doi.org/10.1016/j.fitote.2017.06.015

11. Antidiabetic effect of gomisin N via activation of AMP-activated protein kinase

Author:: Dae Young Jung; Ji-Hyun Kim; Hoyoung Lee; Myeong Ho Jung
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: AMP-activated protein kinase; Schisandra chinensis; animal disease models; beta oxidation; biogenesis; blood glucose; fatty liver; genes; glucose; glucose tolerance; glucose transporters; glycemic effect; high fat diet; in vivo studies; insulin; lignans; metabolic syndrome; mice; mitochondria; myotubes; obesity; phosphorylation; plasma membrane; skeletal muscle
Abstract:: ... Gomisin N (GN) is a lignan derived from Schisandra chinensis. AMP-activated kinase (AMPK) has gained attention as a therapeutic target for the treatment of metabolic syndrome. Previously, we reported that GN activated the AMPK pathway and ameliorated high-fat diet (HFD)-induced hepatic steatosis. In this study, we investigated the anti-diabetic effects of GN in C2C12 myotubes and HFD obese mice. G ...
DOI:: 10.1016/j.bbrc.2017.10.120
: https://doi.org/10.1016/j.bbrc.2017.10.120

12. Antioxidant and antimicrobial activity of linseed lignans and phenolic acids

Author:: Jan Kyselka; Dobrochna Rabiej; Miroslav Dragoun; František Kreps; Zuzana Burčová; Irena Němečková; Jana Smolová; Marie Bjelková; Aleksandra Szydłowska-Czerniak; Štefan Schmidt; Luděk Šarman; Vladimír Filip
Source:: European food research & technology 2017 v.243 no.9 pp. 1633-1644
ISSN:: 1438-2377
Subject:: Gram-negative bacteria; Gram-positive bacteria; antimicrobial properties; antioxidants; bioactive compounds; caffeic acid; chromatography; ferulic acid; hydrolysis; levulinic acid; lignans; linseed; lipid peroxidation; mass spectrometry; median effective concentration; molds (fungi); oxidation; p-coumaric acid; pressing; reaction kinetics; secondary metabolites; solvents; stoichiometry; triacylglycerols; yeasts
Abstract:: ... In this study, we present antioxidant and antimicrobial activity of isolated lignans freed of other bioactive compounds in comparison with dominant phenolic acids. The combinations of screw pressing, solvent extractions, acid-catalysed hydrolysis and flash chromatography were used to describe and isolate linseed phenolic compounds. Secoisolariciresinol, ferulic, p-coumaric and caffeic acids were t ...
DOI:: 10.1007/s00217-017-2871-9
: https://doi.org/10.1007/s00217-017-2871-9

13. Antioxidant and cytotoxic lignans from the roots of Bupleurum chinense

Author:: Dan-Qi Li; Di Wang; Le Zhou; Ling-Zhi Li; Qing-Bo Liu; Ying-Ying Wu; Jing-Yu Yang; Shao-Jiang Song; Chun-Fu Wu
Source:: Journal of Asian natural products research 2017 v.19 no.5 pp. 519-527
ISSN:: 1477-2213
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Bupleurum chinense; antioxidant activity; bioactive compounds; cytotoxicity; ethanol; fluorouracil; free radical scavengers; glucosides; inhibitory concentration 50; lignans; neoplasm cells; nuclear magnetic resonance spectroscopy; roots; spectral analysis
Abstract:: ... In the search for biologically active compounds from the roots of Bupleurum chinense D C., phytochemical investigation of its ethanol extract led to the isolation and identification of a new 8- O -4′ neolignan glucoside, saikolignanoside A (1), along with eight known lignans (2–9). Their structures were determined on the basis of IR, UV, HRESIMS, and NMR spectroscopic analyses. The antioxidant and ...
DOI:: 10.1080/10286020.2016.1234456
: https://doi.org/10.1080/10286020.2016.1234456

14. Antiplasmodial Securinega alkaloids from Phyllanthus fraternus: Discovery of natural (+)-allonorsecurinine

Author:: Gustav Komlaga; Grégory Genta-Jouve; Sandrine Cojean; Rita A. Dickson; Merlin L.K. Mensah; Philippe M. Loiseau; Pierre Champy; Mehdi A. Beniddir
Source:: Tetrahedron letters 2017 pp. -
ISSN:: 0040-4039
Subject:: Phyllanthus fraternus; Plasmodium falciparum; Securinega; alkaloids; antimalarials; antiparasitic properties; chemical reactions; chemical structure; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:: ... The chemical investigation of the antimalarial plant Phyllanthus fraternus G. L. Webster (Phyllanthaceae) resulted in the discovery of the Securinega alkaloid (+)-allonorsecurinine (1), previously reported as a synthetic compound, together with the known ent-norsecurinine (2), nirurine (3), bubbialine (4), epibubbialine (5) and the lignan phyllanthin (6). The structure and absolute configuration o ...
DOI:: 10.1016/j.tetlet.2017.08.045
: https://doi.org/10.1016/j.tetlet.2017.08.045

15. Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome

Author:: Shimeng Zhang; Liangjun Jiang; Fengyuan Che; Yucheng Lu; Zhongxiang Xie; Hao Wang
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: Arctium lappa; brain; infarction; inflammasomes; interleukin-18; interleukin-1beta; ischemia; lignans; neuroprotective effect; protein synthesis; rats; secretion; signal transduction; stroke; surgery; water content
Abstract:: ... Arctigenin (ARC), a phenylpropanoid dibenzylbutyrolactone lignan derived from Arctium lappa L, has been reported to protect against cerebral ischemia injury in rats, but the underlying mechanism is unclear. In this study, we investigated whether ARC ameliorated ischemic stroke by inhibiting NLRP3 inflammasome-derived neuroinflammation and whether SIRT1 signaling was involved in this process. ARC ( ...
DOI:: 10.1016/j.bbrc.2017.08.062
: https://doi.org/10.1016/j.bbrc.2017.08.062

16. Arctigenin represses TGF-β-induced epithelial mesenchymal transition in human lung cancer cells

Author:: Yanrui Xu; Zhiyuan Lou; Seong-Ho Lee
Source:: Biochemical and biophysical research communications 2017 v.493 pp. 934-939
ISSN:: 0006-291X
Subject:: Asteraceae; antineoplastic activity; beta catenin; cadherins; dose response; epithelium; humans; lignans; lung neoplasms; metastasis; mitogen-activated protein kinase; models; neoplasm cells; phosphorylation; snails; toxicity; transcription (genetics)
Abstract:: ... Arctigenin (ARC) is a lignan that is abundant in Asteraceae plants, which show anti-inflammatory and anti-cancer activities. The current study investigated whether ARC affects cancer progression and metastasis, focusing on EMT using invasive human non-small cell lung cancer (NSCLC) cells. No toxicity was observed in the cells treated with different doses of ARC (12–100 μM). The treatment of ARC re ...
DOI:: 10.1016/j.bbrc.2017.09.117
: https://doi.org/10.1016/j.bbrc.2017.09.117

17. Arctigenin suppresses renal interstitial fibrosis in a rat model of obstructive nephropathy

Author:: Ao Li; Xiaoxun Zhang; Mao Shu; Mingjun Wu; Jun Wang; Jingyao Zhang; Rui Wang; Peng Li; Yitao Wang
Source:: Phytomedicine 2017 v.30 pp. 28-41
ISSN:: 0944-7113
Subject:: Arctium lappa; animal disease models; anti-inflammatory activity; antioxidant activity; atrophy; chemokine CCL2; collagen; disease prevention; epithelium; fibrosis; fruits; furans; histology; inflammation; interferon-gamma; interleukin-1beta; kidney diseases; lignans; lipid peroxidation; macrophages; messenger RNA; oxidative stress; phytopharmaceuticals; protein phosphorylation; rats; renal tubules; renoprotective effect; superoxide dismutase; transcription factor NF-kappa B; transforming growth factor beta 1; tumor necrosis factor-alpha
Abstract:: ... Renal tubulointerstitial fibrosis (TIF) is commonly the final result of a variety of progressive injuries and leads to end-stage renal disease. There are few therapeutic agents currently available for retarding the development of renal TIF.The aim of the present study is to evaluate the role of arctigenin (ATG), a lignan component derived from dried burdock (Arctium lappa L.) fruits, in protecting ...
DOI:: 10.1016/j.phymed.2017.03.003
: https://doi.org/10.1016/j.phymed.2017.03.003

18. Association between Urinary Phytoestrogens and C-reactive Protein in the Continuous National Health and Nutrition Examination Survey

Author:: Michael K. Reger; Terrell W. Zollinger; Ziyue Liu; Josette Jones; Jianjun Zhang
Source:: Journal of the American College of Nutrition 2017 v.36 no.6 pp. 434-441
ISSN:: 1541-1087
Subject:: C-reactive protein; National Health and Nutrition Examination Survey; biomarkers; blood serum; cardiovascular diseases; confidence interval; inflammation; lignans; neoplasms; plant estrogens; risk; risk reduction; United States
Abstract:: ... Objective : A reduced risk of some cancers and cardiovascular disease associated with phytoestrogen intake may be mediated through its effect on serum C-reactive protein (CRP; an inflammation biomarker). Therefore, this study examined the associations between urinary phytoestrogens and serum CRP. Methods : Urinary phytoestrogen and serum CRP data obtained from 6009 participants aged ≥ 40 years in ...
DOI:: 10.1080/07315724.2017.1318722
: https://doi.org/10.1080/07315724.2017.1318722

19. Association between polyphenol intake and adherence to the Mediterranean diet in Sicily, southern Italy

Author:: Justyna Godos; Giuseppina Rapisarda; Stefano Marventano; Fabio Galvano; Antonio Mistretta; Giuseppe Grosso
Source:: NFS journal 2017 v.8 pp. 1-7
ISSN:: 2352-3646
Subject:: Mediterranean diet; adults; anthocyanins; apigenin; databases; dietary nutrient sources; eating habits; ferulic acid; food intake; hesperetin; lignans; matairesinol; myricetin; naringenin; polyphenols; questionnaires; regression analysis; traditional foods; urban areas; Italy; Sicily
Abstract:: ... Mediterranean diet has been demonstrated to exert beneficial effects toward various health outcomes. Among the compounds that may be responsible for such benefits, polyphenols have been proposed as potential candidates. The aim of this study was to evaluate whether dietary polyphenols were associated with adherence to the Mediterranean diet in a Sicilian cohort.A total of 1937 adults were recruite ...
DOI:: 10.1016/j.nfs.2017.06.001
: https://doi.org/10.1016/j.nfs.2017.06.001

20. Associations between Both Lignan and Yogurt Consumption and Cardiovascular Risk Parameters in an Elderly Population: Observations from a Cross-Sectional Approach in the PREDIMED Study

Author:: Anna Creus-Cuadros; Anna Tresserra-Rimbau; Paola Quifer-Rada; Miguel Angel Martínez-González; Dolores Corella; Jordi Salas-Salvadó; Montse Fitó; Ramon Estruch; Enrique Gómez-Gracia; José Lapetra; Fernando Arós; Miquel Fiol; Emili Ros; Lluís Serra-Majem; Xavier Pintó; Juan José Moreno; Miguel Ruiz-Canela; Jose Vicente Sorli; Josep Basora; Helmut Schröder; Rosa Maria Lamuela-Raventós; PREDIMED Study Investigators
Source:: Journal of the Academy of Nutrition and Dietetics 2017 v.117 no.4 pp. 609-622.e1
ISSN:: 2212-2672
Subject:: biomarkers; blood pressure; body mass index; cardiovascular diseases; cross-sectional studies; dairy consumption; diet study techniques; eating habits; elderly; glucose; human health; lignans; linear models; low density lipoprotein cholesterol; men; risk; triacylglycerols; waist circumference; women; yogurt
Abstract:: ... The study of dietary patterns is gaining interest. Although the health benefits of yogurt and lignans have been investigated separately, to our knowledge there are no studies on their associative effects.The aim of this study was to evaluate a possible association between yogurt and lignans using biomarkers of cardiovascular disease risk in an elderly population.We conducted a cross-sectional anal ...
DOI:: 10.1016/j.jand.2016.11.003
: https://doi.org/10.1016/j.jand.2016.11.003

21. Asymmetric synthesis of furofurans

Author:: Manat Pohmakotr; Chutima Kuhakarn; Vichai Reutrakul; Darunee Soorukram
Source:: Tetrahedron letters 2017 pp. -
ISSN:: 0040-4039
Subject:: bioactive properties; chemical reactions; chemical structure; lignans; stereochemistry; stereoselectivity
Abstract:: ... Furofurans are one of the largest sub-types of classical lignans which have been found to possess a broad range of important biological activities. Tremendous efforts have been directed to develop synthetic methodologies for the synthesis of furofurans, especially in a stereoselective manner, due to their interesting bioactivities associated with the structural and stereochemical complexity. This ...
DOI:: 10.1016/j.tetlet.2017.11.011
: https://doi.org/10.1016/j.tetlet.2017.11.011

22. Bifidobacterium adolescentis INIA P784: The first probiotic bacterium capable of producing enterodiol from lignan extracts

Author:: Pilar Gaya; Ángela Peirotén; Margarita Medina; José Ma Landete
Source:: Journal of functional foods 2017 v.29 pp. 269-274
ISSN:: 1756-4646
Subject:: Bifidobacterium adolescentis; bioavailability; biotechnology; functional foods; human health; intestinal microorganisms; lactic acid bacteria; lignans; linseed; matairesinol; metabolism; probiotics
Abstract:: ... Lignans are phytoestrogens found in plant foods and especially in flax seeds. Although lignans present a low bioavailability, their transformation into the enterolignans enterodiol (END) and enterolactone (ENL) is associated with beneficial effects on human health. Lignan metabolism was studied in 90 lactic acid bacteria and bifidobacteria finding a wide distribution of the ability to deglycosylat ...
DOI:: 10.1016/j.jff.2016.12.044
: https://doi.org/10.1016/j.jff.2016.12.044

23. Bioactive Asarone-Derived Phenylpropanoids from the Rhizome of Acorus tatarinowii Schott

Author:: Gao En; Zhou Zheng-Qun; Zou Jian; Yu Yang; Feng Xiao-Lin; Chen Guo-Dong; He Rong-Rong; Yao Xin-Sheng; Gao Hao
Source:: Journal of natural products 2017 v.80 no.11 pp. 2923-2929
ISSN:: 1520-6025
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Acorus gramineus; acarbose; acetylcholinesterase; alpha-glucosidase; antioxidant activity; antioxidants; benzene; drugs; enantiomers; enzyme inhibition; high performance liquid chromatography; inhibitory concentration 50; lignans; phenylpropanoids; rhizomes; spectral analysis
Abstract:: ... Eight new (1a/1b, 2a, 3a, 4a/4b, and 5a/5b) and seven known (2b, 3b, and 6–10) asarone-derived phenylpropanoids, a known asarone-derived lignan (12), and four known lignan analogues (11 and 13–15) were isolated from the rhizome of Acorus tatarinowii Schott. The structures were elucidated via comprehensive spectroscopic analyses, modified Mosher’s method, and quantum chemical calculations. Compound ...
DOI:: 10.1021/acs.jnatprod.7b00457
: https://doi.org/10.1021/acs.jnatprod.7b00457

24. Bioactive Glycosides from the Twigs of Litsea cubeba

Author:: Wang Ling-Yan; Chen Ming-Hua; Wu Jiang; Sun Hua; Liu Wei; Qu Yu-Hong; Li Yan-Cheng; Wu Yu-Zhuo; Li Rui; Zhang Dan; Wang Su-Juan; Lin Sheng
Source:: Journal of natural products 2017 v.80 no.6 pp. 1808-1818
ISSN:: 1520-6025
Subject:: Litsea cubeba; X-ray diffraction; air drying; branches; circular dichroism spectroscopy; glucosides; human cell lines; inhibitory concentration 50; lignans; medicinal plants; nuclear magnetic resonance spectroscopy
Abstract:: ... The air-dried twigs of Litsea cubeba, a traditional Chinese medicinal tree, afforded 10 new aromatic glycosides (1–10) and 26 known analogues. Their structures were assigned by extensive 1D and 2D NMR experiments, and the absolute configurations were resolved by chemical methods, electronic circular dichroism, specific rotation, and X-ray crystallographic analysis. Compound 4 is the first example ...
DOI:: 10.1021/acs.jnatprod.6b01189
: https://doi.org/10.1021/acs.jnatprod.6b01189

25. Bioactive lignans and flavones with in vitro antioxidant and neuroprotective properties from Rubus idaeus rhizome

Author:: Yang Xu; Ling-Zhi Li; Qian Cong; Wei Wang; Xiao-Li Qi; Ying Peng; Shao-Jiang Song
Source:: Journal of functional foods 2017 v.32 pp. 160-169
ISSN:: 1756-4646
Subject:: Rubus idaeus; antioxidant activity; antioxidants; ethanol; flavones; fruits; herbal medicines; leaves; lignans; neurodegenerative diseases; neuroprotective effect; rhizomes
Abstract:: ... Rubus idaeus L. is caneberries from the genus Rubus that have been cultivated as food and herbal medicine, and is known to demonstrate strong antioxidant capability. In the present study, five new lignans, along with 13 known compounds, were isolated from ethanol extracts of R. idaeus rhizomes. An HPLC-MS/MS method was established and successfully applied to quantification of 14 compounds from lea ...
DOI:: 10.1016/j.jff.2017.02.022
: https://doi.org/10.1016/j.jff.2017.02.022

26. Bioactive lignans from the stems of Mappianthus iodoides

Author:: Zhi-Hua Jiang; Ling Chai; Yan-Ping Liu; Hong-Cong Qiu; Ting-Ting Wang; Xing-Yang Feng; Yi-Tong Wang; Ze-Hao Huang; Bu-Ming Liu; Yan-Hui Fu
Source:: Phytochemistry letters 2017 v.22 pp. 194-198
ISSN:: 1874-3900
Subject:: anti-inflammatory activity; cortisol; inhibitory concentration 50; lignans; lipopolysaccharides; macrophages; mice; nitric oxide; spectroscopy; stems
Abstract:: ... Two new lignans, mappianthines A (1) and B (2), along with ten known analogues (3-12), were isolated from the stems of Mappianthus iodoides. The structures with the absolute configurations of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literatures. All new compounds were evaluated for their ...
DOI:: 10.1016/j.phytol.2017.10.012
: https://doi.org/10.1016/j.phytol.2017.10.012

27. Bioactive phenolics from in vitro cultures of Lactuca aculeata Boiss. et Kotschy

Author:: Anna Stojakowska; Janusz Malarz
Source:: Phytochemistry letters 2017 v.19 pp. 7-11
ISSN:: 1874-3900
Subject:: Lactuca; caffeic acid; callus culture; chlorogenic acid; glucosides; lignans; sesquiterpenoid lactones
Abstract:: ... A callus culture of Lactuca aculeata, except for commonly distributed caffeic acid derivatives typically found in the Asteraceae family (chlorogenic acid, methyl caffeate, 1,5- dicaffeoylquinic acid), yielded bioactive lignans: (+)-5-methoxybalanophonin, syringaresinol, (+)-balanophonin-9-O-β-glucopyranoside, (+) buddlenol A, (−)-dihydrodehydrodiconiferyl alcohol-4-O-β-glucopyranoside and (−)-dihy ...
DOI:: 10.1016/j.phytol.2016.11.003
: https://doi.org/10.1016/j.phytol.2016.11.003

28. Bioactive phytochemicals in barley

Author:: Emmanuel Idehen; Yao Tang; Shengmin Sang
Source:: Yàowù shípǐn fēnxī 2017 v.25 no.1 pp. 148-161
ISSN:: 1021-9498
Subject:: antioxidants; barley; beta-glucans; cardiovascular diseases; cholesterol; chronic diseases; diabetes; drugs; epidemiological studies; flavonoids; folic acid; lignans; neoplasms; obesity; phenolic acids; phytosterols; risk; risk reduction; whole grain foods
Abstract:: ... Epidemiological studies have consistently shown that regular consumption of whole grain barley reduces the risk of developing chronic diseases. The presence of barley fiber, especially β-glucan in whole grain barley, has been largely credited for these health benefits. However, it is now widely believed that the actions of the fiber component alone do not explain the observed health benefits assoc ...
DOI:: 10.1016/j.jfda.2016.08.002
: https://doi.org/10.1016/j.jfda.2016.08.002

29. The Breast Cancer Resistance Protein (BCRP/ABCG2) influences the levels of enterolignans and their metabolites in plasma, milk and mammary gland

Author:: Dafne García-Mateos; Rocío García-Villalba; José Angel Marañón; Juan Carlos Espín; Gracia Merino; Ana I. Álvarez
Source:: Journal of functional foods 2017 v.35 pp. 648-654
ISSN:: 1756-4646
Subject:: animal tissues; breast neoplasms; chemoprevention; dietary supplements; digestive system; females; functional foods; ingestion; lignans; mammary glands; metabolites; mice; milk; plant estrogens; polyphenols
Abstract:: ... Lignans are phytoestrogens widely used in dietary supplements and functional foods. After oral ingestion, these polyphenols are metabolized to enterolignans, the main gut microbiota-derived metabolites with weak estrogenic/anti-estrogenic activities. The ABCG2 transporter is highly expressed in the mammary gland and could be responsible for enterolignan accumulation. We aimed here at evaluating th ...
DOI:: 10.1016/j.jff.2017.06.038
: https://doi.org/10.1016/j.jff.2017.06.038

30. Can sesame consumption improve blood pressure? A systematic review and meta‐analysis of controlled trials

Author:: Hossein Khosravi‐Boroujeni; Elham Nikbakht; Ernesta Natanelov; Saman Khalesi
Source:: Journal of the science of food and agriculture 2017 v.97 no.10 pp. 3087-3094
ISSN:: 0022-5142
Subject:: blood pressure; databases; hypertension; lignans; meta-analysis; myocardial infarction; phytosterols; polyunsaturated fatty acids; renal failure; risk factors; stroke; systematic review
Abstract:: ... Hypertension is a major risk factor for cardiovascular disease, myocardial infarction, stroke and renal failure. Sesame consumption may benefit blood pressure (BP) owing to its high polyunsaturated fatty acid, fibre, phytosterol and lignan contents. To clarify this, a systematic review and meta‐analysis of controlled trials was conducted. The PubMed (MEDLINE), Cumulative Index to Nursing and Allie ...
DOI:: 10.1002/jsfa.8361
: https://doi.org/10.1002/jsfa.8361

31. Changes in phenolic composition in olive tree parts according to development stage

Author:: Leila Abaza; Amani Taamalli; David Arráez-Román; Antonio Segura-Carretero; Alberto Fernández-Gutierrérez; Mokhtar Zarrouk; Nabil Ben Youssef
Source:: Food research international 2017 v.100 pp. 454-461
ISSN:: 0963-9969
Subject:: Olea europaea; buds; cinnamic acid; detectors; flavonoids; flowers; freeze drying; fruit extracts; fruits; high performance liquid chromatography; leaves; lignans; mass spectrometry; methanol; olives; phenols; secoiridoids; tissues; Tunisia
Abstract:: ... The aim of this study was to investigate the changes in the phenolic profile in different organs (buds, flowers, fruits and leaves) from Chemlali olive variety cultivated in the Center of Tunisia according to development stage. Phenolics recovery was carried out using aqueous methanol from freeze-dried powdered tissues. The extracts were then analyzed by using high performance liquid chromatograph ...
DOI:: 10.1016/j.foodres.2016.12.002
: https://doi.org/10.1016/j.foodres.2016.12.002

32. Characterization of Phase I and Phase II Hepatic Metabolism and Reactive Intermediates of Larrea nitida Cav. and Its Lignan Compounds

Author:: Hyesoo Jeong; Soolin Kim; Jimin Lee; Jin Young Park; Wenmei Zhou; Xiyuan Liu; So Dam Kim; Yun Seon Song; Chang‐Young Jang; Sei‐Ryang Oh; Sangho Choi; Minsun Chang
Source:: Phytotherapy research 2017 v.31 no.1 pp. 140-151
ISSN:: 0951-418X
Subject:: Larrea; NADP (coenzyme); antioxidants; bioactive compounds; cytochrome P-450; enzymes; glutathione; inhibitory concentration 50; isozymes; lignans; liver microsomes; metabolism; metabolites; methanol; models; nicotinamide; nordihydroguaiaretic acid; phosphates; rats; toxicity; uridine; Chile
Abstract:: ... Larrea nitida Cav. (LNC), which belongs to the family Zygophyllaceae, is widely indigenous and used in South America to treat various pathological conditions. It contains the antioxidant and antiinflammatory but toxic nordihydroguaiaretic acid (NDGA) as well as O‐methylated metabolite of NDGA (MNDGA) as bioactive compounds. The hepatic metabolism‐based toxicological potential of extracts of LNC (L ...
DOI:: 10.1002/ptr.5742
: https://doi.org/10.1002/ptr.5742

33. Characterization of some potential medicinal plants from Central Europe by their antioxidant capacity and the presence of metal elements

Author:: Michal Tupec; Veronika Hýsková; Kateřina Bělonožníková; Jakub Hraníček; Václav Červený; Helena Ryšlavá
Source:: Food bioscience 2017 v.20 pp. 43-50
ISSN:: 2212-4292
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Agrimonia eupatoria; Mentha piperita; Origanum vulgare; antioxidant activity; calcium; diet; drinking; electrons; flavonoids; herbal tea; humans; hydrogen; lignans; magnesium; medicinal plants; phenolic acids; plant extracts; polyphenols; potassium; selenium; sodium; sodium chloride; stilbenes; zinc; Central European region
Abstract:: ... Plants contain polyphenolic compounds such as phenolic acids, flavonoids, stilbenes, lignans, etc., which are endowed with antioxidant properties. The aim of this study was to correlate the total phenolic compound and flavonoid content of 15 medicinal plants with their antioxidant properties and to determine some important essential elements (Na, K, Ca, Mg, Zn, Se). The antioxidant capacity was te ...
DOI:: 10.1016/j.fbio.2017.08.001
: https://doi.org/10.1016/j.fbio.2017.08.001

34. Chemical Composition and Immuno‐Modulatory Effects of Urtica dioica L. (Stinging Nettle) Extracts

Author:: Marina Francišković; Raquel Gonzalez‐Pérez; Dejan Orčić; Fermín Sánchez de Medina; Olga Martínez‐Augustin; Emilija Svirčev; Nataša Simin; Neda Mimica‐Dukić
Source:: Phytotherapy research 2017 v.31 no.8 pp. 1183-1191
ISSN:: 0951-418X
Subject:: chemoattractants; kaempferol; secretion; Urtica dioica; chemokine CCL2; glucosides; intestinal mucosa; dietary supplements; liquid chromatography; protective effect; isoquercitrin; rutin; oncogenes; phytopharmaceuticals; humans; linoleate 13S-lipoxygenase; aerial parts; lignans; immune response; chemical composition; monocytes; phenolic acids; inflammation; tandem mass spectrometry; prostaglandin synthase
Abstract:: ... The purpose of this work was to determine the chemical profile of stinging nettle and to provide an insight into the mechanisms by which it ameliorates the immune response. Qualitative and quantitative liquid chromatography tandem mass spectrometry analyses indicated that phenolic acids (5‐O‐caffeoylquinic acid as dominant) and flavonol glycosides (rutin, isoquercitrin, and kaempferol 3‐O‐glucosid ...
DOI:: 10.1002/ptr.5836
: https://doi.org/10.1002/ptr.5836

35. Chemical Composition and UVA-Protecting Activity of Extracts from Ligustrum vulgare and Olea europaea Leaves

Author:: Monika E. Czerwińska; Katarzyna Duszak; Andrzej Parzonko; Anna K. Kiss
Source:: Acta biologica Cracoviensia 2017 v.58 no.2 pp. 45-55
ISSN:: 1898-0295
Subject:: Ligustrum vulgare; Olea europaea; apoptosis; cell viability; chemical composition; fibroblasts; flavonoids; herbal medicines; humans; leaf extracts; leaves; lignans; models; oleuropein; olives; phenylpropanoids; propidium; protective effect; reactive oxygen species; skin diseases; staining; Mediterranean region; Northern European region
Abstract:: ... Plants belonging to the family Oleaceae have been traditionally used in treatment of various inflammatory skin disorders. One of the most well-known species is Olea europaea L. (olive), cultivated in the Mediterranean countries. Another species is Ligustrum vulgare L. (common privet), occurring particularly in Northern Europe and Asia.The aim of the study was a comparison of the composition of aqu ...
DOI:: 10.1515/abcsb-2016-0016
: https://doi.org/10.1515/abcsb-2016-0016

36. Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa

Author:: Kuo Ping-Chung; Hung Hsin-Yi; Nian Chi-Wei; Hwang Tsong-Long; Cheng Ju-Chien; Kuo Daih-Huang; Lee E-Jian; Tai Shih-Huang; Wu Tian-Shung
Source:: Journal of natural products 2017 v.80 no.4 pp. 1055-1064
ISSN:: 1520-6025
Subject:: Forsythia suspensa; anti-inflammatory activity; chemical composition; diterpenoids; elastase; fruits; inhibitory concentration 50; lignans; spectroscopy; superoxide anion; triterpenoids
Abstract:: ... Fifty compounds were isolated from the fruits of Forsythia suspensa, including 13 new compounds characterized as eight new diterpenoids (1–8), three new lignans (9–11), a new iridoid (12), and a new triterpenoid (13). Their structures were established on the basis of spectroscopic and spectrometric analysis. Most of the isolated compounds were examined for their anti-inflammatory activity in vitro ...
DOI:: 10.1021/acs.jnatprod.6b01141
: https://doi.org/10.1021/acs.jnatprod.6b01141

37. Chemical constituents from Piper boehmeriifolium (Miq.) Wall. ex C. DC

Author:: Tie Liu; Qian Liang; Xin-Min Zhang; Gen-Qian Li; Bo Xu; Wen-Hui Xu
Source:: Biochemical systematics and ecology 2017 v.75 pp. 27-30
ISSN:: 0305-1978
Subject:: Piper; alkaloids; chemical composition; chemotaxonomy; diterpenoids; lignans; monoterpenoids; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:: ... The chemical investigation of whole plants Piper boehmeriifolium (Miq.) Wall. ex C. DC. led to the isolation of 22 compounds, including two lignans (1–2), sixteen amide alkaloids (3–18), one diterpene (19), two monoterpenes (20–21), and one phenylpropanoid (22). Their structures were elucidated by extensive spectroscopic analyses including NMR, MS, and by comparison with the literature. Compounds ...
DOI:: 10.1016/j.bse.2017.11.003
: https://doi.org/10.1016/j.bse.2017.11.003

38. Chemical profiling and antioxidant evaluation of Yangxinshi Tablet by HPLC–ESI-Q-TOF-MS/MS combined with DPPH assay

Author:: Junfeng Zhu; Xiaojiao Yi; Jinghui Zhang; Shuqing Chen; Yongjiang Wu
Source:: Journal of chromatography 2017 v.1060 pp. 262-271
ISSN:: 1570-0232
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Oriental traditional medicine; alkaloids; anthraquinones; antioxidant activity; ascorbic acid; cardiovascular diseases; chemical composition; clinical trials; coumarin; flavanoids; free radical scavengers; glycosides; high performance liquid chromatography; inhibitory concentration 50; lignans; mass spectrometry; mechanism of action; oral administration; rapid methods; rats; salvianolic acid; screening; triterpenoids
Abstract:: ... Yangxinshi Tablet (YXST) is a Chinese patent medicine commonly used to treat cardiovascular diseases. However, its detailed chemical basis and mechanisms of action have not been clarified. In this study, high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (HPLC–ESI-Q-TOF-MS) was applied for comprehensive analysis of the chemical c ...
DOI:: 10.1016/j.jchromb.2017.06.022
: https://doi.org/10.1016/j.jchromb.2017.06.022

39. Chemical study of Anthospermum emirnense (Rubiaceae)

Author:: Tiana Sylvia Ralambonirina Rasoarivelo; Raphaël Grougnet; Sylvie Michel; Christiane Rakotobe Guillou; Brigitte Deguin
Source:: Biochemical systematics and ecology 2017 v.70 pp. 186-191
ISSN:: 0305-1978
Subject:: Rubiaceae; aerial parts; anthraquinones; benzoic acids; chemotaxonomy; coumarin; flavonoids; iridoid glycosides; lignans; triterpenoids
Abstract:: ... Chemical study of the aerial parts of Anthospermum emirnense led to the isolation of one original iridoid glycoside (1) along with six known iridoids (2–7), three lignans (8–10), two flavonoids (11–12), one coumarin (13), two anthraquinones (14–15), two benzoic acids (16–17) and three triterpenoids (18–20). These results are the first chemical data on non-volatile constituents of this genus. The c ...
DOI:: 10.1016/j.bse.2016.11.010
: https://doi.org/10.1016/j.bse.2016.11.010

40. Chiral separation and chemical profile of Dengzhan Shengmai by integrating comprehensive with multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

Author:: Ning Sheng; Hao Zheng; Yao Xiao; Zhe Wang; Menglin Li; Jinlan Zhang
Source:: Journal of chromatography 2017 v.1517 pp. 97-107
ISSN:: 0021-9673
Subject:: Oriental traditional medicine; chemical composition; comprehensive two-dimensional liquid chromatography; cutting; flavonoids; herbs; high performance liquid chromatography; isomers; lignans; mass spectrometry; saponins
Abstract:: ... Chemical profile for Chinese medicine formulas composed of several herbs is always a challenge due to a big array of small molecules with high chemical diversity so much as isomers. The present paper develops a feasible strategy to characterize and identify complex chemical constituents of a four-herb traditional Chinese medicine formula, Denzhan Shenmai (DZSM) by integrating comprehensive two-dim ...
DOI:: 10.1016/j.chroma.2017.08.037
: https://doi.org/10.1016/j.chroma.2017.08.037

41. Comparative analysis of the in-vitro antioxidant activity and bioactive compounds of flaxseed in China according to variety and geographical origin

Author:: Qianchun Deng; Xiao Yu; Fangli Ma; Jiqu Xu; Fenghong Huang; Qingde Huang; Feng Sheng
Source:: International journal of food properties 2017 v.20 no.sup3 pp. S2708
ISSN:: 1094-2912
Subject:: 2,2-diphenyl-1-picrylhydrazyl; alpha-linolenic acid; antioxidant activity; antioxidants; bioactive compounds; chemometrics; glucosides; lignans; linseed; p-coumaric acid; phytosterols; principal component analysis; provenance; syringic acid; China
Abstract:: ... The present study aimed to use a chemometric study to compare the in-vitro antioxidant activities and bioactive compounds of flaxseed based on the variety and geographical origins, and further explore the specific components constructed the endogenous antioxidant system of flaxseed in China. The differential contents of α-linolenic acid (35.83–58.91%), lignans (11.37–33.31 mg/g), total phenolic ac ...
DOI:: 10.1080/10942912.2017.1402029
: https://doi.org/10.1080/10942912.2017.1402029

42. Comprehensive profiling and characterization of chemical constituents of rhizome of Anemarrhena asphodeloides Bge.

Author:: De Ji; Zi-yan Huang; Cheng-hao Fei; Wei-wei Xue; Tu-lin Lu
Source:: Journal of chromatography 2017 v.1060 pp. 355-366
ISSN:: 1570-0232
Subject:: Anemarrhena asphodeloides; chemical composition; cyclic peptides; fatty acids; flavones; herbal medicines; ions; lignans; mass spectrometry; metabolites; quality control; rhizomes; steroid saponins; ultra-performance liquid chromatography; xanthones; China
Abstract:: ... The rhizome of Anemarrhena asphodeloides Bge. is commonly used as an herbal medicine in China. In this study, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) was used, in both negative and positive ion modes, to comprehensively analyze the chemical constituents of A. asphodeloides. From the intact precursor ions, MS/MS fragmenta ...
DOI:: 10.1016/j.jchromb.2017.06.032
: https://doi.org/10.1016/j.jchromb.2017.06.032

43. Configuration and stability of naturally occurring all-cis-tetrahydrofuran lignans from Piper solmsianum

Author:: Clécio S. Ramos; Harrald V. Linnert; Marcilio M. de Moraes; João H. do Amaral; Lydia F. Yamaguchi; Massuo J. Kato
Source:: RSC advances 2017 v.7 no.74 pp. 46932-46937
ISSN:: 2046-2069
Subject:: Piper; density functional theory; hydrogen bonding; isomers; leaves; lignans; nuclear magnetic resonance spectroscopy; spectral analysis; tetrahydrofuran
Abstract:: ... The study of variability of the tetrahydrofuran lignan (−)-grandisin in leaves of Piper solmsianum (Piperaceae) revealed two unknown compounds, that were isolated and determined to be the all-cis tetrahydrofuran lignans 1a [rel-(7R,8S,7′S,8′R)-3,4,5,3′,4′,5′-hexamethoxy-7,7′-epoxylignan] and 1b [rel-(7R,8S,7′S,8R′)-3′,4′-methylenedioxy-3,4,5,5′-tetramethoxy-7,7′-epoxylignan]. Their structures were ...
DOI:: 10.1039/c7ra09262h
: https://doi.org/10.1039/c7ra09262h

44. The Contents of Lignans in Sesame Seeds and Commercial Sesame Oils of China

Author:: Long‐Kai Shi; Rui‐Jie Liu; Qing‐Zhe Jin; Xing‐Guo Wang
Source:: The journal of the American Oil Chemists' Society 2017 v.94 no.8 pp. 1035-1044
ISSN:: 0003-021X
Subject:: high performance liquid chromatography; lignans; seeds; sesame oil; sesame seed; China
Abstract:: ... In this study, the concentrations of three lignans in 100 sesame seeds and 56 sesame oils were determined using a newly developed method based on high‐performance liquid chromatography coupled with a UV/Vis detector. Total lignan contents in sesame seed and oil samples ranged from 2.52 to 12.76 and 3.38 to 11.53 mg/g, respectively. Black sesame seeds showed higher sesamin content (range 1.98–9.41 ...
DOI:: 10.1007/s11746-017-3018-7
: https://doi.org/10.1007/s11746-017-3018-7

45. Cytotoxic neolignans from the traditional Chinese medicine Daphniphyllum macropodum Miq.

Author:: Xinhua Ma; Jie Yang; Christopher L. Brown; Chao Wang; Shihao Deng; Ruifang Ke; Shicheng Xu; Mi Huang; Xinzhou Yang; Yunjiang Feng
Source:: RSC advances 2017 v.7 no.83 pp. 52970-52976
ISSN:: 2046-2069
Subject:: Daphniphyllum; Oriental traditional medicine; apoptosis; benzaldehyde; caspase-3; caspase-9; cell growth; cell lines; circular dichroism spectroscopy; cytotoxicity; dose response; humans; lignans; mitochondria; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; seeds; spectral analysis
Abstract:: ... Four new neolignans, (E)-3-(hydroxymethyl)-2-(4-hydroxyphenyl)-5-(prop-1-en-1-yl)benzofuran-6-ol (1), methyl (E)-6-hydroxy-2-(4-hydroxyphenyl)-5-(prop-1-en-1-yl)benzofuran-3-carboxylate (2), (R)-4-hydroxy-3-(1-(4-hydroxyphenyl)propan-2-yl)benzaldehyde (3) and methyl (E,R)-3-(4-hydroxy-3-(1-(4-hydroxyphenyl)propan-2-yl)phenyl)acrylate (4) were isolated from the seeds of Daphniphyllum macropodum Miq ...
DOI:: 10.1039/c7ra09569d
: https://doi.org/10.1039/c7ra09569d

46. Derivatives of the Lignan 7′-Hydroxymatairesinol with Antioxidant Properties and Enhanced Lipophilicity

Author:: Moraux Thomas; Dumarçay Stéphane; Gérardin Philippe; Gérardin-Charbonnier Christine
Source:: Journal of natural products 2017 v.80 no.6 pp. 1783-1790
ISSN:: 1520-6025
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Abies alba; Picea abies; Pseudotsuga menziesii; alpha-tocopherol; antioxidant activity; ascorbic acid; butylated hydroxytoluene; esterification; hydrophobicity; inhibitory concentration 50; lignans; ultra-performance liquid chromatography
Abstract:: ... The lignan 7′-hydroxymatairesinol (1), extracted from the knotwoods of fir (Abies alba), spruce (Picea abies), and Douglas fir (Pseudotsuga menziesii), exhibited unexpected reactivity when esterification reactions were attempted on the hydroxy group at position C-7′. To circumvent the rapid intramolecular cyclization procedure, leading quantitatively to the lignan conidendrin (7), a simple strateg ...
DOI:: 10.1021/acs.jnatprod.6b01124
: https://doi.org/10.1021/acs.jnatprod.6b01124

47. Diacylglycerol acyltransferase 1 (DGAT1) inhibition by furofuran lignans from stems of Acanthopanax senticosus

Author:: Ban-Ban Li; Jia-Lin Li; Na Li; Shi-Zhou Qi; Hyun-Sun Lee; Le Zhang; Shan-Shan Xing; Zhen-Dong Tuo; Long Cui
Source:: Archives of pharmacal research 2017 v.40 no.11 pp. 1271-1277
ISSN:: 0253-6269
Subject:: Eleutherococcus senticosus; diacylglycerol acyltransferase; inhibitory concentration 50; lignans; spectral analysis; stems
Abstract:: ... Two new furofuran lignans were isolated from the stems of Acanthopanax senticosus, along with seven known compounds. Their structures were all determined by spectroscopic analyses and chemical methods. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Compounds 1 and 2 were found to exhibit selective inhibitory activity on DGAT1 with IC₅₀ values 89.5 ± 1.5 a ...
DOI:: 10.1007/s12272-016-0842-5
: https://doi.org/10.1007/s12272-016-0842-5

48. Diarylpropanes and lignans from Horsfieldia tetratepala

Author:: Shou-Zhen Du; Zhi-Chong Wang; Ying Liu; Rui Zhan; Ye-Gao Chen
Source:: Phytochemistry letters 2017 v.19 pp. 98-100
ISSN:: 1874-3900
Subject:: acetone; branches; cytotoxicity; lignans; neoplasms; spectral analysis
Abstract:: ... Two new diarylpropanes (1–2), four known compounds, and a new artifact, were isolated from 70% aqueous acetone extract of the twigs of Horsfieldia tetratepala. Their structures were elucidated by spectroscopic analysis. Cytotoxicity evaluation against five cancer cell lines showed that none of these compounds was cytotoxic. ...
DOI:: 10.1016/j.phytol.2016.12.018
: https://doi.org/10.1016/j.phytol.2016.12.018

49. Dibenzocyclooctadiene lignans from Kadsura heteroclita

Author:: Yuan-Qing Luo; Miao Liu; Jin Wen; Wei-Guang Wang; Kun Hu; Xiao-Nian Li; Xue Du; Jian-Xin Pu; Han-Dong Sun
Source:: Fitoterapia 2017 v.119 pp. 150-157
ISSN:: 0367-326X
Subject:: X-ray diffraction; cytotoxicity; inhibitory concentration 50; lignans; spectroscopy; stems
Abstract:: ... Sixteen dibenzocyclooctadiene lignans, including eight new ones, kadheterins A–H (1–8), and a new natural product, 9-benzoyloxy-gomisin B (9), were isolated from the stems of K. heteroclita. The structures of 1–9 were elucidated by extensive spectroscopic methods, and their absolute configurations were determined by combining CD with ROESY experiments. Additionally, the absolute configuration of 1 ...
DOI:: 10.1016/j.fitote.2017.04.013
: https://doi.org/10.1016/j.fitote.2017.04.013

50. Differential effects of in vitro cultures of Linum usitatissimum L. (Flax) on biosynthesis, stability, antibacterial and antileishmanial activities of zinc oxide nanoparticles: a mechanistic approach

Author:: Bilal Haider Abbasi; Sumaira Anjum; Christophe Hano
Source:: RSC advances 2017 v.7 no.26 pp. 15931-15943
ISSN:: 2046-2069
Subject:: Fourier transform infrared spectroscopy; Leishmania major; Linum usitatissimum; X-ray diffraction; adventitious roots; antileishmanial properties; biosynthesis; callus; carboxylic acids; chemical constituents of plants; flax; lignans; multiple drug resistance; nanoparticles; parasites; polyphenols; reducing agents; scanning electron microscopy; stabilizers; ultraviolet-visible spectroscopy; zinc oxide
Abstract:: ... The use of plants and plant-derived materials for biosynthesis of zinc oxide nanoparticles (ZnO NPs) is developing into a lucrative field of green nanotechnology and gaining more importance owing to its simplicity, rapidity, and eco-friendliness. In present study, a novel and efficient green approach has been developed for biosynthesis of ZnO NPs by exploiting the in vitro platform of plants. Two ...
DOI:: 10.1039/c7ra02070h
: https://doi.org/10.1039/c7ra02070h

51. Differential responses of Scots pine stilbene synthase and chalcone synthase genes to Heterobasidion annosum infection

Author:: A. Kovalchuk; L. Zhu; S. Keriö; F. O. Asiegbu
Source:: Forest pathology 2017 v.47 no.4 pp. -
ISSN:: 1437-4781
Subject:: Heterobasidion annosum; Pinus sylvestris; biosynthesis; chalcone; conifers; esters; fungi; genes; hypocotyls; isoflavonoids; lignans; mature plants; naringenin-chalcone synthase; pathogens; phenylpropanoids; proanthocyanidins; seedlings; stilbenoids; transcription (genetics); trees; trihydroxystilbene synthase
Abstract:: ... Phenolic compounds are essential components of the defensive chemical arsenal of conifer trees. This chemically diverse group encompasses stilbenoids, flavonoids, isoflavonoids, proanthocyanidins and lignans. All of them are produced from the common precursors, CoA esters of the phenylpropanoids: p‐coumaroyl‐CoA, cinnamoyl‐CoA, caffeoyl‐CoA and feruloyl‐CoA. Two classes of enzymes, stilbene syntha ...
DOI:: 10.1111/efp.12348
: https://doi.org/10.1111/efp.12348

52. Direct study of minor extra-virgin olive oil components without any sample modification. 1H NMR multisupression experiment: A powerful tool

Author:: Ainhoa Ruiz-Aracama; Encarnación Goicoechea; María D. Guillén
Source:: Food chemistry 2017 v.228 pp. 301-314
ISSN:: 0308-8146
Subject:: adulterated products; chloroform; extra-virgin olive oil; fatty alcohols; hydrolysis; lignans; metabolomics; nuclear magnetic resonance spectroscopy; oleocanthal; oxidation; protons; squalene; sterols; triterpene acids; wax esters
Abstract:: ... Proton Nuclear Magnetic Resonance (1H NMR) was employed to study monovarietal commercial Spanish extra-virgin olive oils (EVOO) (Arbequina, Arroniz, Cornicabra, Hojiblanca and Picual). Each sample was analyzed by a standard pulse and by an experiment suppressing the main lipid signals, enabling the detection of signals of minor components. The aim was to determine the possibilities of both 1H NMR ...
DOI:: 10.1016/j.foodchem.2017.02.009
: https://doi.org/10.1016/j.foodchem.2017.02.009

53. Diterpenoids and Lignans from Cephalotaxus fortunei

Author:: Zhao Jin-Xin; Fan Yao-Yue; Xu Jin-Biao; Gan Li-She; Xu Cheng-Hui; Ding Jian; Yue Jian-Min
Source:: Journal of natural products 2017 v.80 no.2 pp. 356-362
ISSN:: 1520-6025
Subject:: Cephalotaxus; X-ray diffraction; anticarcinogenic activity; biosynthesis; branches; chemical structure; cytotoxicity; diterpenoids; inhibitory concentration 50; leaves; lignans
Abstract:: ... Five new diterpenoids including two Cephalotaxus troponoids (1 and 2), two 17-nor-cephalotane-type diterpenoids (3 and 4), and an abietane-type diterpenoid (5), two new lignans (6 and 7), and a new trisnorneoligan (8) along with eight known compounds were identified from the twigs and leaves of Cephalotaxus fortunei. The structure of 11-hydroxyhainanolidol was revised as 10-hydroxyhainanolidol (9) ...
DOI:: 10.1021/acs.jnatprod.6b00802
: https://doi.org/10.1021/acs.jnatprod.6b00802

54. Effect of Antibiotics and Diet on Enterolactone Concentration and Metabolome Studied by Targeted and Nontargeted LC–MS Metabolomics

Author:: Bolvig Anne K.; Nørskov Natalja P.; Hedemann Mette S.; Foldager Leslie; McCarthy-Sinclair Brendan; Marco Maria L.; Lærke Helle N.; Bach Knudsen Knud E.
Source:: Journal of Proteome Research 2017 v.16 no.6 pp. 2135-2150
ISSN:: 1535-3907
Subject:: antibiotics; blood lipids; diet; epidemiological studies; humans; intestinal microorganisms; lignans; lipid composition; liquid chromatography; low density lipoprotein cholesterol; mass spectrometry; metabolism; metabolites; metabolome; metabolomics; microbial communities; proteome; ribosomal RNA; sequence analysis; swine; swine feeding
Abstract:: ... High plant lignan intake is associated with a number of health benefits, possibly induced by the lignan metabolite enterolactone (ENL). The gut microbiota plays a crucial role in converting dietary lignans into ENL, and epidemiological studies have shown that use of antibiotics is associated with lower levels of ENL. Here we investigate the link between antibiotic use and lignan metabolism in pigs ...
DOI:: 10.1021/acs.jproteome.6b00942
: https://doi.org/10.1021/acs.jproteome.6b00942

55. Effect of Sesamin Supplementation on Glycemic Status, Inflammatory Markers, and Adiponectin Levels in Patients with Type 2 Diabetes Mellitus

Author:: Majid Mohammad Shahi; Mehrnoosh Zakerzadeh; Mehrnoosh Zakerkish; Mehdi Zarei; Azadeh Saki
Source:: Journal of dietary supplements 2017 v.14 no.1 pp. 65-75
ISSN:: 1939-022X
Subject:: C-reactive protein; adiponectin; adiposity; antioxidant activity; blood glucose; blood serum; clinical trials; glycohemoglobin; hip circumference; insulin; interleukin-6; lignans; noninsulin-dependent diabetes mellitus; placebos; starch; therapeutics; tumor necrosis factor-alpha; waist circumference
Abstract:: ... Background: Sesamin is one of the most abundant lignans in sesame and has multiple functions and high values such as antioxidative effect and promoting-immunity function. The aim of this study was to evaluate the effects of sesamin supplementation on glycemic status, serum levels of inflammatory markers and adiponectinin patients with type 2 diabetes mellitus. Material and Methods: Forty-eight pat ...
DOI:: 10.1080/19390211.2016.1204404
: https://doi.org/10.1080/19390211.2016.1204404

56. Effects of photoperiod regimes and ultraviolet-C radiations on biosynthesis of industrially important lignans and neolignans in cell cultures of Linum usitatissimum L. (Flax)

Author:: Sumaira Anjum; Bilal Haider Abbasi; Joël Doussot; Alain Favre-Réguillon; Christophe Hano
Source:: Journal of photochemistry and photobiology 2017 v.167 pp. 216-227
ISSN:: 1011-1344
Subject:: Linum usitatissimum; alcohols; antioxidant activity; bioactive compounds; biomarkers; biosynthesis; cell culture; flavonoids; flax; glucosides; lignans; medicinal properties; photoperiod; reversed-phase high performance liquid chromatography; ultraviolet radiation
Abstract:: ... Lignans and neolignans are principal bioactive components of Linum usitatissimum L. (Flax), having multiple pharmacological activities. In present study, we are reporting an authoritative abiotic elicitation strategy of photoperiod regimes along with UV-C radiations. Cell cultures were grown in different photoperiod regimes (24h–dark, 24h–light and 16L/8D h photoperiod) either alone or in combinat ...
DOI:: 10.1016/j.jphotobiol.2017.01.006
: https://doi.org/10.1016/j.jphotobiol.2017.01.006

57. Enantiomeric 8-O-4′ type neolignans from red raspberry as potential inhibitors of β-amyloid aggregation

Author:: Le Zhou; Li-Li Lou; Wei Wang; Bin Lin; Jun-Ning Chen; Xiao-Bo Wang; Xiao-Xiao Huang; Shao-Jiang Song
Source:: Journal of functional foods 2017 v.37 pp. 322-329
ISSN:: 1756-4646
Subject:: Alzheimer disease; Rubus idaeus; chemical composition; chemical structure; functional foods; lignans; neuroprotective effect; spectral analysis; stereochemistry
Abstract:: ... Red raspberry (Rubus idaeus L.) is an edible fruit-producing species belonging to the Rosaceae family. In our search for potential agents for treating Alzheimer’s disease in this functional food, we decided to investigate the chemical constituents of red raspberry. Four pairs of enantiomeric 8-O-4′-type neolignans (1a/1b–4a/4b), including three new compounds (1a/1b and 2a), were identified from th ...
DOI:: 10.1016/j.jff.2017.08.007
: https://doi.org/10.1016/j.jff.2017.08.007

58. Ent-kaurene diterpenoids and lignan from Leontopodium leontopodioides and their inhibitory activities against cyclooxygenases-1 and 2

Author:: Chu-Lu Qi; En Wang; Li-Qin Jin; Ming Yan; Xiao-Qi Zhang; Hao Wang; Wen-Cai Ye
Source:: Phytochemistry letters 2017 v.21 pp. 94-97
ISSN:: 1874-3900
Subject:: Leontopodium leontopodioides; aerial parts; anti-inflammatory activity; diterpenoids; lignans; phenolic acids; prostaglandin synthase; spectroscopy
Abstract:: ... Two new ent-kaurene diterpenoids, 13α,15α-dihydroxy-18-carboxy-19-nor-ent-kaur-16-ene-2β-O-(2′-angelate)-β-d-glucopyranoside (leontocin A, 1), 13α,15α-dihydroxy-18-carboxy-19-nor-ent-kaur-16-ene-2β-O-(2′-angelate-6′-acetyl)-β-d-glucopyranoside (leontocin B, 2), and one new lignan, 2,3-bis[(3,4-di-hydroxyphenyl)methylene]-monoethyl ester-butanedioic acid (leontolignan A, 3), together with three kno ...
DOI:: 10.1016/j.phytol.2017.06.019
: https://doi.org/10.1016/j.phytol.2017.06.019

59. Enumeration of carboxyl groups carried on individual components of humic systems using deuteromethylation and Fourier transform mass spectrometry

Author:: Alexander Zherebker; Yury Kostyukevich; Alexey Kononikhin; Oleg Kharybin; Andrey I. Konstantinov; Kirill V. Zaitsev; Eugene Nikolaev; Irina V. Perminova
Source:: Analytical and bioanalytical chemistry 2017 v.409 no.9 pp. 2477-2488
ISSN:: 1618-2642
Subject:: carbohydrates; chemical elements; elemental composition; esterification; fractionation; humic substances; isotope labeling; lignans; lignin; mass spectrometry; solid phase extraction; tannins; transesterification
Abstract:: ... Here, we report a novel approach to enumeration of carboxylic groups carried by individual molecules of humic substances using selective chemical modification and isotopic labeling (deuteromethylation) and high-resolution electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI FTICR MS). Esterification was conducted with a use of thionyl chloride–deuteromethanol re ...
DOI:: 10.1007/s00216-017-0197-x
: https://doi.org/10.1007/s00216-017-0197-x

60. Evaluation of antioxidant activity, total phenolics, total flavonoids and LC–MS/MS characterisation of phenolic constituents in Stachys lavandulifolia

Author:: Soroush Rahimi Khoigani; Ahmad Rajaei; Sayed Amir Hossein Goli
Source:: Natural product research 2017 v.31 no.3 pp. 355-358
ISSN:: 1478-6427
Subject:: Stachys lavandulifolia; absorbance; aldehydes; antioxidant activity; butylated hydroxytoluene; coumaric acids; coumarin; gallic acid; inhibitory concentration 50; iron; lignans; quercetin; stilbenes; tannins
Abstract:: ... The aim of this study was to evaluate phenolics profile and antioxidant activity of Stachys lavandulifolia. Total phenolics (TP), total flavonoids (TF), DPPH• assay (IC50), ferric ion reducing antioxidant power (FRAP) and total antioxidant capacity (TAC) of the methanolic extract were measured. The content of TP, TF, IC50, FRAP and TAC, were obtained as 16.59 gallic acid equiv./g dry matter (DM), ...
DOI:: 10.1080/14786419.2016.1233410
: https://doi.org/10.1080/14786419.2016.1233410

61. Evaluation of phenolic profile and antioxidant capacity in gluten-free flours

Author:: Gabriele Rocchetti; Giulia Chiodelli; Gianluca Giuberti; Francesco Masoero; Marco Trevisan; Luigi Lucini
Source:: Food chemistry 2017 v.228 pp. 367-373
ISSN:: 0308-8146
Subject:: anthocyanins; antioxidant activity; black rice; brown rice; chickpeas; gallic acid; gluten-free foods; health promotion; lentils; lignans; oats; rice flour; wheat flour
Abstract:: ... The characterization of phenolic fingerprints in common gluten-free flours is still scarce. Total phenolic and anthocyanin contents, antioxidant capacity and the entire phenolic profile were investigated for extracts from chickpea, sorghum, quinoa, black rice, lentil, amaranth, brown rice, oat and white rice flours, using soft wheat flour as a comparison. The highest phenolic content was found in ...
DOI:: 10.1016/j.foodchem.2017.01.142
: https://doi.org/10.1016/j.foodchem.2017.01.142

62. Expression in Pichia pastoris and characterization of two novel dirigent proteins for atropselective formation of gossypol

Author:: Isabelle Effenberger; Michael Harport; Jens Pfannstiel; Iris Klaiber; Andreas Schaller
Source:: Applied microbiology and biotechnology 2017 v.101 no.5 pp. 2021-2032
ISSN:: 0175-7598
Subject:: cotton; proteins; biosynthesis; Komagataella pastoris; free radicals; glycosylation; biomimetics; gossypol; Gossypium barbadense; lignans; affinity chromatography; mass spectrometry; batch fermentation
Abstract:: ... We established an efficient fed-batch fermentation process for two novel dirigent proteins from cotton plants, GbDIR2 from Gossypium barbadense and GhDIR3 from G. hirsutum, using the engineered Pichia pastoris GlycoSwitch® SuperMan₅ strain to prevent hyperglycosylation. The two (His)₆-tagged proteins were purified by metal-chelate affinity chromatography and obtained in quantities of 12 and 15 mg ...
DOI:: 10.1007/s00253-016-7997-3
: https://doi.org/10.1007/s00253-016-7997-3

63. Extraction of Flaxseed Oil: A Comparative Study of Three-Phase Partitioning and Supercritical Carbon Dioxide Using Response Surface Methodology

Author:: Nikhil G Kulkarni; Jayaranjan R Kar; Rekha S Singhal
Source:: Food and bioprocess technology 2017 v.10 no.5 pp. 940-948
ISSN:: 1935-5130
Subject:: 2,2-diphenyl-1-picrylhydrazyl; acid value; antioxidant activity; carbon dioxide; cooking fats and oils; economic sustainability; free radical scavengers; iodine value; lignans; linseed; linseed oil; omega-3 fatty acids; oxidative stability; peroxide value; proteins; response surface methodology; solvents; supercritical fluid extraction; ultrasonics
Abstract:: ... Flaxseed has gained significant interest as a source of edible oil that is rich in omega-3 fatty acids, high content of flaxseed proteins and lignans that are known to be therapeutic. Low oxidative stability of flaxseed oil necessitates the use of extraction technologies that are advanced and economically viable than the currently used cold press extraction. This work compares the yield and qualit ...
DOI:: 10.1007/s11947-017-1877-4
: https://doi.org/10.1007/s11947-017-1877-4

64. Extraction of bioactive compounds from sesame (Sesamum indicum L.) defatted seeds using water and ethanol under sub-critical conditions

Author:: Romina Bodoira; Alexis Velez; Alfonsina E. Andreatta; Marcela Martínez; Damián Maestri
Source:: Food chemistry 2017 v.237 pp. 114-120
ISSN:: 0308-8146
Subject:: Sesamum indicum; ambient temperature; bioactive compounds; butylated hydroxytoluene; ethanol; gallic acid; lignans; phenols; quercetin; response surface methodology; seeds; sesame cake; sesame seed
Abstract:: ... Sesame seeds contain a vast array of lignans and phenolic compounds having important biological properties. An optimized method to obtain these seed components was designed by using water and ethanol at high pressure and temperature conditions. The maximum concentrations of lignans, total phenolics, flavonoids and flavonols compounds were achieved at 220°C extraction temperature and 8MPa pressure, ...
DOI:: 10.1016/j.foodchem.2017.05.102
: https://doi.org/10.1016/j.foodchem.2017.05.102

65. Fargesin exerts anti-inflammatory effects in THP-1 monocytes by suppressing PKC-dependent AP-1 and NF-ĸB signaling

Author:: Thu-Huyen Pham; Man-Sub Kim; Minh-Quan Le; Yong-Seok Song; Yesol Bak; Hyung-Won Ryu; Sei-Ryang Oh; Do-Young Yoon
Source:: Phytomedicine 2017 v.24 pp. 96-103
ISSN:: 0944-7113
Subject:: Magnolia biondii; Oriental traditional medicine; Western blotting; anti-inflammatory activity; chemokines; drugs; enzyme-linked immunosorbent assay; fluorescent antibody technique; genes; humans; inducible nitric oxide synthase; interleukin-1beta; lignans; luciferase; messenger RNA; mitogen-activated protein kinase; monocytes; nose; prostaglandin synthase; protein kinase C; protein synthesis; quantitative polymerase chain reaction; sinusitis; transcription factor NF-kappa B; tumor necrosis factor-alpha; viability
Abstract:: ... Fargesin is a lignan from Magnolia fargesii, an oriental medicine used in the treatment of nasal congestion and sinusitis. The anti-inflammatory properties of this compound have not been fully elucidated yet.This study focused on assessing the anti-inflammatory effects of fargesin on phorbal ester (PMA)-stimulated THP-1 human monocytes, and the molecular mechanisms underlying them.Cell viability w ...
DOI:: 10.1016/j.phymed.2016.11.014
: https://doi.org/10.1016/j.phymed.2016.11.014

66. Flavonol glycosides and lignans from the leaves of Opilia amentacea

Author:: Abdulmagid Alabdul Magid; Anaëlle Abdellah; Virginie Pecher; Laure Pasquier; Dominique Harakat; Laurence Voutquenne-Nazabadioko
Source:: Phytochemistry letters 2017 v.21 pp. 84-89
ISSN:: 1874-3900
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Opiliaceae; antioxidant activity; flavonols; glycosides; inhibitory concentration 50; leaves; lignans; mushrooms; spectral analysis
Abstract:: ... Two previously undescribed flavonol tetraglycosides, isorhamnetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (1) and isorhamnetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→6)-β-d-galactopyranoside (2), along with nine known compounds including seven flavonoids and two lignans, were isolated from the l ...
DOI:: 10.1016/j.phytol.2017.05.023
: https://doi.org/10.1016/j.phytol.2017.05.023

67. Flaxseed and multigrain mixtures in the development of functional biscuits

Author:: Nikolina Čukelj; Dubravka Novotni; Hrvoje Sarajlija; Saša Drakula; Bojana Voučko; Duška Ćurić
Source:: Lebensmittel-Wissenschaft + Technologie 2017 v.86 pp. 85-92
ISSN:: 0023-6438
Subject:: antioxidant activity; baking; barley; bioavailability; biscuits; ingredients; lignans; linseed; lipid peroxidation; markets; oat flour; oats; oxidative stability; phenolic acids; rye; sensory properties; texture; wheat
Abstract:: ... Market reports show an increasing interest for healthy biscuits, with omega-3 and lignan rich flaxseeds being highlighted as key ingredients. Usage of milled flaxseed in comparison to the whole seed might improve bioaccessibility of lignans and omega-3, but also accelerate lipid oxidation, thus diminishing the consumers' acceptability.This research investigated the nutritional (lignans, omega-3, p ...
DOI:: 10.1016/j.lwt.2017.07.048
: https://doi.org/10.1016/j.lwt.2017.07.048

68. Flaxseed secoisolariciresinol diglucoside (SDG) during lactation improves bone metabolism in offspring at adulthood

Author:: Mariana Sarto Figueiredo; Ligia de Albuquerque Maia; Deysla Sabino Guarda; Patricia Cristina Lisboa; Egberto Gaspar de Moura
Source:: Journal of functional foods 2017 v.29 pp. 161-171
ISSN:: 1756-4646
Subject:: adulthood; adults; bone density; bone metabolism; diet; estrogenic properties; females; lactation; lignans; linseed; males; maternal exposure; mineral content; mothers; progeny; pups; skeletal development; weaning
Abstract:: ... Secoisolariciresinol diglucoside (SDG), flaxseed lignan, has estrogenic effects and since flaxseed causes several dysfunctions in adult offspring from mothers supplemented during lactation, we hypothesized that maternal exposure to SDG during lactation changes bone parameters on adult offspring. At birth, dams (4 male and 4 female pups/litter) were divided into: standard diet (control group) or a ...
DOI:: 10.1016/j.jff.2016.12.021
: https://doi.org/10.1016/j.jff.2016.12.021

69. Four new neolignans isolated from Eleutherococcus senticosus and their protein tyrosine phosphatase 1B inhibitory activity (PTP1B)

Author:: Le Zhang; Ban-Ban Li; Hao-Ze Li; Xiao Meng; Xin Lin; Yi-Yu Jiang; Jong-Seog Ahn; Long Cui
Source:: Fitoterapia 2017 pp. -
ISSN:: 0367-326X
Subject:: Eleutherococcus senticosus; inhibitory concentration 50; lignans; protein-tyrosine-phosphatase; spectroscopy
Abstract:: ... Four new compounds, erythro-7′E-4-Hydroxy-3,3′-dimethoxy-8,5′-oxyneoligna-7′-ene-7,9-diol-9′-al (1), (7S,8S)-4-Hydroxy-3,1′,3′-trimethoxy-4′,7-epoxy-8,5′-neolign-9-ol (5), (7S,8S,7′E)-5-Hydroxy-3,3′-dimethoxy-4′,7-epoxy-8,5′-neolign-7′-ene-9,9′-diol (6) and (7S,8S,7′E)-5-Hydroxy-3,3′,9′-trimethoxy-4′-7-epoxy-8,5′-neolign-7′-ene-9-ol (7). Along with four known compounds (2–4, 8) were isolated from ...
DOI:: 10.1016/j.fitote.2017.06.025
: https://doi.org/10.1016/j.fitote.2017.06.025

70. Functional characterization of the pinoresinol–lariciresinol reductase-2 gene reveals its roles in yatein biosynthesis and flax defense response

Author:: Cyrielle Corbin; Samantha Drouet; Ivan Mateljak; Lucija Markulin; Cédric Decourtil; Sullivan Renouard; Tatiana Lopez; Joël Doussot; Frédéric Lamblin; Daniel Auguin; Eric Lainé; Elisabeth Fuss; Christophe Hano
Source:: Planta 2017 v.246 no.3 pp. 405-420
ISSN:: 0032-0935
Subject:: Linum usitatissimum; RNA interference; aerial parts; biosynthesis; enantiomers; enzymes; flax; genes; leaves; lignans; methyl jasmonate; quantitative polymerase chain reaction; regulatory sequences; reverse transcriptase polymerase chain reaction; seeds; stress response; tissues; transgenesis
Abstract:: ... MAIN CONCLUSION: This study provides new insights into the biosynthesis regulation and in planta function of the lignan yatein in flax leaves. Pinoresinol–lariciresinol reductases (PLR) catalyze the conversion of pinoresinol into secoisolariciresinol (SECO) in lignan biosynthesis. Several lignans are accumulated in high concentrations, such as SECO accumulated as secoisolariciresinol diglucoside ( ...
DOI:: 10.1007/s00425-017-2701-0
: https://doi.org/10.1007/s00425-017-2701-0

71. Furofuran lignan glucosides from the leaves of Vitex negundo var. cannabifolia

Author:: Yue-Ting Li; Man-Man Li; Jing Sun; Zhi-Xiang Zhu; Yue-Lin Song; Dao-Ran Pang; Jiao Zheng; Yun-Fang Zhao; Peng-Fei Tu; Jun Li
Source:: Natural product research 2017 v.31 no.8 pp. 918-924
ISSN:: 1478-6427
Subject:: Vitex negundo; glucosides; inhibitory concentration 50; leaves; lignans; nitric oxide; spectral analysis; spectroscopy
Abstract:: ... Two new furofuran lignan glucosides, cannabilignin (1) and isocannabilignin (2), together with four known compounds (3 – 6), were isolated from the leaves of Vitex negundo var. cannabifolia . The structures of the isolates were elucidated by analysis of spectroscopic data. Compound 3 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC ...
DOI:: 10.1080/14786419.2016.1255887
: https://doi.org/10.1080/14786419.2016.1255887

72. Furofuran lignans from the Simpson Desert species Eremophila macdonnellii

Author:: Yuen P. Tan; Andrei I. Savchenko; Natasa Broit; Glen M. Boyle; Peter G. Parsons; Craig M. Williams
Source:: Fitoterapia 2017 pp. -
ISSN:: 0367-326X
Subject:: antineoplastic activity; arid zones; breast neoplasms; lignans; phytopharmaceuticals; traditional medicine; Australia
Abstract:: ... The Eremophila plant family, which occurs in the arid zones of Australia, have witnessed extensive investigation, mostly inspired by Aboriginal traditional medicine. A wide and varied biological and phytochemical profile has been reported for over 18 individual species of Australian Eremophila, although E. macdonnellii from the Simpson Desert has not yet been investigated. Isolation and elucidatio ...
DOI:: 10.1016/j.fitote.2017.06.004
: https://doi.org/10.1016/j.fitote.2017.06.004

73. Gardenifolins A–H, Scalemic Neolignans from Gardenia ternifolia: Chiral Resolution, Configurational Assignment, and Cytotoxic Activities against the HeLa Cancer Cell Line

Author:: Tshitenge Dieudonné Tshitenge; Feineis Doris; Awale Suresh; Bringmann Gerhard
Source:: Journal of natural products 2017 v.80 no.5 pp. 1604-1614
ISSN:: 1520-6025
Subject:: Gardenia ternifolia; apoptosis; bark; circular dichroism spectroscopy; cytotoxicity; diastereomers; enantiomers; high performance liquid chromatography; humans; inhibitory concentration 50; lignans; neoplasms; nuclear magnetic resonance spectroscopy; reversed-phase liquid chromatography; stereochemistry
Abstract:: ... From the tropical plant Gardenia ternifolia Schumach. and Thonn. (Rubiaceae), eight stereoisomeric 2,3-dihydrobenzo[b]furan neolignans, named gardenifolins A–H (1a–d and 2a–d), were isolated and fully structurally characterized. Reversed-phase chromatography of a stem bark extract afforded two peaks, viz. mixtures I and II, each one consisting of two diastereomers and their respective enantiomers. ...
DOI:: 10.1021/acs.jnatprod.7b00180
: https://doi.org/10.1021/acs.jnatprod.7b00180

74. Genetic toxicity of Epimedium koreanum Nakai

Author:: Youn-Hwan Hwang; Hey Jin Yang; Nam-Hui Yim; Jin Yeul Ma
Source:: Journal of ethnopharmacology 2017 v.198 pp. 87-90
ISSN:: 0378-8741
Subject:: chromosome aberrations; flavonoids; genotoxicity; glycosides; herbal medicines; lignans; liquid chromatography; mammals; mutagens; mutation; phenolic acids; phytopharmaceuticals; tandem mass spectrometry; traditional medicine; East Asia
Abstract:: ... In Eastern Asia, E. koreanum Nakai (EKN) has traditionally been used as an aphrodisiac herbal medicine. However, there was no available information for its genotoxicity. This study was conducted to evaluate the genotoxic potentials of EKN.The phytochemicals of EKN were identified using liquid chromatography/tandem mass spectrometry (LC/MS/MS). Three standard battery of genotoxicity assay for bacte ...
DOI:: 10.1016/j.jep.2016.11.050
: https://doi.org/10.1016/j.jep.2016.11.050

75. Genistein and enterolactone in relation to Ki‐67 expression and HER2 status in postmenopausal breast cancer patients

Author:: Stefanie Jaskulski; Audrey Y. Jung; Anja Rudolph; Theron Johnson; Kathrin Thöne; Esther Herpel; Peter Sinn; Jenny Chang‐Claude
Source:: Molecular nutrition & food research 2017 v.61 no.11 pp. -
ISSN:: 1613-4125
Subject:: breast neoplasms; cell proliferation; erbB-2 receptor; genistein; lignans; metabolites; patients; plant estrogens; postmenopause; prognosis; regression analysis
Abstract:: ... SCOPE: Phytoestrogens (PE) may improve breast cancer prognosis by modifying tumor prognostic markers, such as cell proliferation marker Ki‐67 and human epidermal growth factor receptor 2 (HER2). Epidemiological evidence linking lignans and isoflavones to Ki‐67 and HER2 is limited. We examined associations between the major metabolites of lignans and isoflavones – enterolactone (ENL) and genistein ...
DOI:: 10.1002/mnfr.201700449
: https://doi.org/10.1002/mnfr.201700449

76. a- Glucosidase inhibition, anti-glycation and antioxidant activities of Liquidambar formosana Hance leaf, and identification of phytochemical profile

Author:: L. Zhang; M.-f. Zhu; Z.-c. Tu; Y. Zhao; H. Wang; G.-j. Li; X.-m. Sha
Source:: South African journal of botany 2017 v.113 pp. 239-247
ISSN:: 0254-6299
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Liquidambar formosana; advanced glycation end products; antioxidant activity; antioxidants; butanol; diabetic complications; ethyl acetate; flavanols; flavonols; leaves; lignans; phytopharmaceuticals; proanthocyanidins; solvents; tannins
Abstract:: ... This study firstly investigates the ability of Liquidambar formosana Hance leaf (LFHL) against diabetes and diabetic complications. The bio-active constituents in LFHL extract were fractionated with solvents at various polarities. The antioxidant, hypoglycemic and anti-glycation activities, and the content of phenolics, flavonoids, hydrolysable tannins and condensed tannins were measured. The phyt ...
DOI:: 10.1016/j.sajb.2017.08.010
: https://doi.org/10.1016/j.sajb.2017.08.010

77. Hepatoprotective triterpenoids and lignans from the stems of Schisandra pubescens

Author:: Guo-Wei Wang; Li-Qing Deng; You-Ping Luo; Zhi-Hua Liao; Min Chen
Source:: Natural product research 2017 v.31 no.16 pp. 1855-1860
ISSN:: 1478-6427
Subject:: Schisandra; hepatoprotective effect; lignans; nuclear magnetic resonance spectroscopy; spectral analysis; stems; survival rate; triterpenoids
Abstract:: ... One new triterpenoid (1) and 13 known compounds (2–14) were isolated from Schisandra pubescens stems. The structure of the new compound was established on the basis of 1D/2D NMR and HRESIMS spectroscopic analyses. The isolated compounds were evaluated for their hepatoprotective activities against D-GalN-induced cell injury in QSG7701 cells. Compounds 1, 13 and 14 at 10 μM showed hepatoprotective a ...
DOI:: 10.1080/14786419.2016.1261348
: https://doi.org/10.1080/14786419.2016.1261348

78. High‐throughput ultra high performance liquid chromatography combined with mass spectrometry approach for the rapid analysis and characterization of multiple constituents of the fruit of Acanthopanax senticosus (Rupr. et Maxim.) Harms

Author:: Yue Han; Aihua Zhang; Hui Sun; Yingzhi Zhang; Xiangcai Meng; Guangli Yan; Liang Liu; Xijun Wang
Source:: Journal of separation science 2017 v.40 no.10 pp. 2178-2187
ISSN:: 1615-9306
Subject:: B-lymphocytes; Eleutherococcus senticosus; Oriental traditional medicine; T-lymphocytes; blood serum; chemical composition; flavones; heart; kidneys; lignans; mass spectrometry; medicinal properties; natural killer cells; nutrients; phenolic acids; prototypes; rapid methods; skeleton; spleen; ultra-performance liquid chromatography
Abstract:: ... Acanthopanax senticosus (Rupr. et Maxim.) Harms, a traditional Chinese medicine, has been widely used to improve the function of skeleton, heart, spleen and kidney. This fruit is rich in nutrients, but the chemical constituents of Acanthopanax senticosus fruit are still unclear. A rapid method based on ultra high performance liquid chromatography with time‐of‐flight mass spectrometry was developed ...
DOI:: 10.1002/jssc.201601445
: https://doi.org/10.1002/jssc.201601445

79. Identification of metabolites in human and rat urine after oral administration of Xiao‐Qing‐Long‐Tang granule using ultra high performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry

Author:: Lei Zhou; Qiang Zhang; Wen Qi; Shuai Yan; Jialin Qu; Toshiaki Makino; Dan Yuan
Source:: Journal of separation science 2017 v.40 no.18 pp. 3582-3592
ISSN:: 1615-9306
Subject:: alkaloids; biochemical pathways; bronchitis; chemical composition; computer software; essential oils; flavones; ginger; humans; hydroxylation; hypersensitivity; lignans; metabolism; metabolites; nose; oral administration; prototypes; rats; tandem mass spectrometry; ultra-performance liquid chromatography; urine
Abstract:: ... Xiao‐Qing‐Long‐Tang is a traditional Chinese formula used for the treatment of cold syndrome, bronchitis, and nasal allergies for thousands of years. However, the in vivo integrated metabolism of its multiple components and the active chemical constituents of Xiao‐Qing‐Long‐Tang remain unknown. In this study, a method using ultra high performance liquid chromatography coupled with quadrupole time‐ ...
DOI:: 10.1002/jssc.201700423
: https://doi.org/10.1002/jssc.201700423

80. Identification, classification and transcriptional profiles of dirigent domain-containing proteins in sugarcane

Author:: Paula Macedo Nobile; Alexandra Bottcher; Juliana L. S. Mayer; Michael S. Brito; Ivan A. dos Anjos; Marcos Guimarães de Andrade Landell; Renato Vicentini; Silvana Creste; Diego Mauricio Riaño-Pachón; Paulo Mazzafera
Source:: Molecular genetics and genomics 2017 v.292 no.6 pp. 1323-1340
ISSN:: 1617-4615
Subject:: Saccharum officinarum; biosynthesis; cell walls; coniferyl alcohol; culms; fertilizer application; genes; internodes; leaves; lignans; nitrogen; nitrogen fertilizers; phylogeny; pith; proteins; sequence alignment; sucrose; sugarcane; surveys; transcription (genetics); vascular bundles
Abstract:: ... Dirigent (DIR) proteins, encoded by DIR genes, are referred to as “dirigent” because they direct the outcome of the coupling of the monolignol coniferyl alcohol into (+) or (−) pinoresinol, the first intermediates in the enantiocomplementary pathways for lignan biosynthesis. DIR domain-containing or DIR-like proteins are, thus, termed for not having a clear characterization. A transcriptome- and g ...
DOI:: 10.1007/s00438-017-1349-6
: https://doi.org/10.1007/s00438-017-1349-6

81. Identification, in vitro and in vivo Antioxidant Activity, and Gastrointestinal Stability of Lignans from Silver Fir (Abies alba) Wood Extract

Author:: Eva Tavčar Benković; Dušan Žigon; Vladimir Mihailović; Tanja Petelinc; Polona Jamnik; Samo Kreft
Source:: Journal of wood chemistry and technology 2017 v.37 no.6 pp. 467-477
ISSN:: 1532-2319
Subject:: Abies alba; antioxidant activity; ascorbic acid; butylated hydroxytoluene; cell membranes; epigallocatechin gallate; eukaryotic cells; gastrointestinal system; human health; in vitro digestion; in vitro studies; lignans; matairesinol; models; resveratrol; succinic acid; wood; wood extractives; yeasts
Abstract:: ... Lignans are generally known for their beneficial impact on human health. In this study, we found that the water extract of silver fir (Abies alba) wood contains lignans, which constitute approximately 10% of the extract and include isolariciresinol, hydroxymatairesinol, secoisolariciresinol, lariciresinol, pinoresinol, and matairesinol. The antioxidant activity of the extract was measured by sever ...
DOI:: 10.1080/02773813.2017.1340958
: https://doi.org/10.1080/02773813.2017.1340958

82. Impact of boiling on free and bound phenolic profile and antioxidant activity of commercial gluten-free pasta

Author:: Gabriele Rocchetti; Luigi Lucini; Giulia Chiodelli; Gianluca Giuberti; Domenico Montesano; Francesco Masoero; Marco Trevisan
Source:: Food research international 2017 v.100 pp. 69-77
ISSN:: 0963-9969
Subject:: antioxidant activity; black rice; boiling; cooking; flavonoids; gluten-free foods; lignans; pasta; phenolic acids; stilbenes
Abstract:: ... Cooking by boiling dry pasta could have varying degrees of influence on nutritional and functional components. In the present study, its effect on total phenolic content and antioxidant capacity, as well as on the comprehensive profile of free and bound phenolics, was investigated in six commercial gluten-free (GF) pasta products. Overall, the heat treatment caused a significant reduction (P<0.01) ...
DOI:: 10.1016/j.foodres.2017.08.031
: https://doi.org/10.1016/j.foodres.2017.08.031

83. Impact of extraction techniques on antioxidant capacities and phytochemical composition of polyphenol-rich extracts

Author:: Cecilia Castro-López; Janeth M. Ventura-Sobrevilla; María D. González-Hernández; Romeo Rojas; Juan A. Ascacio-Valdés; Cristóbal N. Aguilar; Guillermo C.G. Martínez-Ávila
Source:: Food chemistry 2017 v.237 pp. 1139-1148
ISSN:: 0308-8146
Subject:: Cassia fistula; Juglans regia; Moringa oleifera; Punica granatum; antioxidant activity; antioxidants; chemical elements; flavonoids; lignans; maceration; phenolic acids; phytopharmaceuticals; plant extracts
Abstract:: ... In this work, impact of extraction methods (maceration, decoction, MAE, and UAE) on TPC, antioxidant activity, and the mass fraction of phenolics in several plant extracts (Punica granatum, Juglans regia, Moringa oleifera, and Cassia fistula) was investigated. The results showed that, despite the nature of matrix, the highest values of TPC in all samples were obtained by MAE as follows: PP (18.92± ...
DOI:: 10.1016/j.foodchem.2017.06.032
: https://doi.org/10.1016/j.foodchem.2017.06.032

84. Impact of lignans on the polyunsaturated fatty acid metabolic processing in a rainbow trout (Oncorhynchus mykiss) cell line

Author:: Julie Mellery; Florian Scalisi; Chloé Bonnineau; Patrick Kestemont; Xavier Rollin; Yvan Larondelle
Source:: Aquaculture 2017 v.476 pp. 106-110
ISSN:: 0044-8486
Subject:: Oncorhynchus mykiss; alpha-linolenic acid; biotransformation; diet; eicosapentaenoic acid; fish; fish feeds; fish oils; hepatocytes; in vitro studies; lignans; linseed; linseed oil; lipid metabolism; omega-3 fatty acids; sesame oil; sesame seed
Abstract:: ... In the context of fish oil replacement by alternative plant-derived oils in the fish feed, the influence of lignans, which are phenolic compounds present at significant concentrations in some plant-derived oils, was investigated on the omega-3 (n-3) fatty acid metabolism of the rainbow trout liver cell line RTL-W1 enriched in alpha-linolenic acid (ALA, 18:3n-3). The major linseed oil lignans, name ...
DOI:: 10.1016/j.aquaculture.2017.04.022
: https://doi.org/10.1016/j.aquaculture.2017.04.022

85. In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans

Author:: Puttaraju Srikantamurthy Yashaswini; Bettadahalli Sadashivaiah; Talahalli Ravichandra Ramaprasad; Sridevi Annapurna Singh
Source:: Journal of nutritional biochemistry 2017 v.41 pp. 151-157
ISSN:: 0955-2863
Subject:: blood serum; catalase; glutathione-disulfide reductase; inflammation; interleukin-1beta; leukotrienes; lignans; lipid peroxidation; liver; metabolic diseases; oxidative stress; rats; sesame oil; superoxide dismutase; therapeutics; tumor necrosis factor-alpha
Abstract:: ... The role of inflammation and oxidative stress is critical during onset of metabolic disorders and this has been sufficiently established in literature. In the present study, we evaluated the effects of sesamol and sesamin, two important bioactive molecules present in sesame oil, on the generation of inflammatory and oxidative stress factors in LPS injected rats. Sesamol and sesamin lowered LPS ind ...
DOI:: 10.1016/j.jnutbio.2016.12.010
: https://doi.org/10.1016/j.jnutbio.2016.12.010

86. Influence of Flaxseed Lignan Supplementation to Older Adults on Biochemical and Functional Outcome Measures of Inflammation

Author:: Yunyun Di; Jennifer Jones; Kerry Mansell; Susan Whiting; Sharyle Fowler; Lilian Thorpe; Jennifer Billinsky; Navita Viveky; Pui Chi Cheng; Ahmed Almousa; Thomas Hadjistavropoulos; Jane Alcorn
Source:: Journal of the American College of Nutrition 2017 v.36 no.8 pp. 646-653
ISSN:: 1541-1087
Subject:: adverse effects; blood; cardiovascular diseases; clinical trials; cognition; elderly; human diseases; inflammation; lignans; linseed; lipid composition; oral administration; pain; physical activity; placebos; risk factors; systolic blood pressure; waist
Abstract:: ... Evidence from the literature suggests that dietary flaxseed lignans have the ability to modulate inflammation, which is recognized as the underlying basis of multiple chronic human diseases in older adults. Our objective was to determine the effects of oral lignan supplementation on biochemical and functional indicators of inflammation as well as safety and tolerability in older healthy adults. We ...
DOI:: 10.1080/07315724.2017.1342213
: https://doi.org/10.1080/07315724.2017.1342213

87. Irrigation and fruit canopy position modify oil quality of olive trees (cv. Frantoio)

Author:: Giovanni Caruso; Riccardo Gucci; Maria Isabella Sifola; Roberto Selvaggini; Stefania Urbani; Sonia Esposto; Agnese Taticchi; Maurizio Servili
Source:: Journal of the science of food and agriculture 2017 v.97 no.11 pp. 3530-3539
ISSN:: 0022-5142
Subject:: Olea europaea; canopy; fruiting; irrigation rates; lignans; linoleic acid; lipid content; mesocarp; oleic acid; orchards; trees; virgin olive oil
Abstract:: ... BACKGROUND: Fruit development and oil quality in Olea europaea L. are strongly influenced by both light and water availability. In the present study, the simultaneous effects of light environment and irrigation on fruit characteristics and oil quality were studied in a high‐density orchard over two consecutive years. Olive fruits were harvested from three canopy positions (intercepting approximate ...
DOI:: 10.1002/jsfa.8207
: https://doi.org/10.1002/jsfa.8207

88. Isolation and Identification of the Novel Tubulin Polymerization Inhibitor Bifidenone

Author:: Williams Russell B.; Martin Steven M.; Lawrence Julie A.; Norman Vanessa L.; O’Neil-Johnson Mark; Eldridge Gary R.; Starks Courtney M.
Source:: Journal of natural products 2017 v.80 no.3 pp. 616-624
ISSN:: 1520-6025
Subject:: algorithms; apoptosis; caspases; cytotoxicity; lignans; microtubules; nuclear magnetic resonance spectroscopy; polymerization; screening; structure-activity relationships; tubulin
Abstract:: ... The pursuit of structurally novel compounds has led to the isolation of a series of neolignans (2–6), for which the structures have been determined from microgram quantities using microcryoprobe NMR technology. Compounds 2–6 provided some unexpectedly clear structure–activity relationship data, with compound 2 demonstrating significantly more potency in the in vitro cytotoxicity assay than the oth ...
DOI:: 10.1021/acs.jnatprod.6b00893
: https://doi.org/10.1021/acs.jnatprod.6b00893

89. Isolation of a new β-carboline alkaloid from aerial parts of Triclisia sacleuxii and its antibacterial and cytotoxicity effects

Author:: Fidelis Samita; Charles Otieno Ochieng; Philip Okinda Owuor; Lawrence Onyango Arot Manguro; Jacob Ogweno Midiwo
Source:: Natural product research 2017 v.31 no.5 pp. 529-536
ISSN:: 1478-6427
Subject:: Gram-negative bacteria; Triclisia; adenocarcinoma; aerial parts; alkaloids; antibacterial properties; antibiotics; beta-sitosterol; breast neoplasms; cytotoxicity; humans; hydroxybenzaldehyde; inhibitory concentration 50; lignans; methanol; minimum inhibitory concentration; myricetin; quercetin
Abstract:: ... A new β-carboline alkaloid named sacleuximine A (1) together with known compounds palmatine (2), isotetrandrine (3), trans -N-feruloyltyramine (4), trans -N-caffeoyltyramine (5), yangambin (6), syringaresinol (7), sesamin (8), (+) epi-quercitol (9) , 4-hydroxybenzaldehyde (10), β-sitosterol (11), quercetin 3- O -rutinoside (12) and myricetin 3- O -β-glucose (1→6) α-rhamnoside (13) have been isolat ...
DOI:: 10.1080/14786419.2016.1201666
: https://doi.org/10.1080/14786419.2016.1201666

90. Isolation, Identification, and Biological Evaluation of Phenolic Compounds from a Traditional North American Confectionery, Maple Sugar

Author:: Liu Yongqiang; Rose Kenneth N.; DaSilva Nicholas A.; Johnson Shelby L.; Seeram Navindra P.
Source:: Journal of agricultural and food chemistry 2017 v.65 no.21 pp. 4289-4295
ISSN:: 1520-5118
Subject:: Acer saccharum subsp. saccharum; Caenorhabditis elegans; bioactive compounds; bioactive properties; inflammation; lignans; maple syrup; neuroglia; nuclear magnetic resonance spectroscopy; oxidative stress; sap; sweets; trees
Abstract:: ... Maple sap, collected from the sugar maple (Acer saccharum) tree, is boiled to produce the popular plant-derived sweetener, maple syrup, which can then be further evaporated to yield a traditional North American confectionery, maple sugar. Although maple sap and maple syrup have been previously studied, the phytochemical constituents of maple sugar are unknown. Herein, 30 phenolic compounds, 1–30, ...
DOI:: 10.1021/acs.jafc.7b01969
: https://doi.org/10.1021/acs.jafc.7b01969

91. Kinetics of the incorporation of the main phenolic compounds into the lignan macromolecule during flaxseed development

Author:: Aina Ramsay; Ophélie Fliniaux; Anthony Quéro; Roland Molinié; Hervé Demailly; Christophe Hano; Christian Paetz; Albrecht Roscher; Eric Grand; José Kovensky; Bernd Schneider; François Mesnard
Source:: Food chemistry 2017 v.217 pp. 1-8
ISSN:: 0308-8146
Subject:: alkaline hydrolysis; coumaric acids; developmental stages; flavonoids; flax; glucosides; high performance liquid chromatography; lignans; linseed; nuclear magnetic resonance spectroscopy; seed development
Abstract:: ... The main flax lignan, secoisolariciresinol diglucoside, is stored in a macromolecule containing other ester-bound phenolic compounds. In this study, NMR and HPLC-UV analyses were performed on flaxseeds harvested at different developmental stages to identify and quantify the main phenolic compounds produced during seed development. Extraction was carried out with or without alkaline hydrolysis to d ...
DOI:: 10.1016/j.foodchem.2016.08.039
: https://doi.org/10.1016/j.foodchem.2016.08.039

92. Kudsuphilactone B, a nortriterpenoid isolated from Schisandra chinensis fruit, induces caspase-dependent apoptosis in human ovarian cancer A2780 cells

Author:: Miran Jeong; Hye Mi Kim; Hyun Ji Kim; Jung-Hye Choi; Dae Sik Jang
Source:: Archives of pharmacal research 2017 v.40 no.4 pp. 500-508
ISSN:: 0253-6269
Subject:: 4-hydroxybenzoic acid; B-cell lymphoma; NAD ADP-ribosyltransferase; Schisandra chinensis; acetates; apoptosis; caspase-3; cytotoxicity; dose response; fruits; humans; indole acetic acid; inhibitory concentration 50; lignans; mitogen-activated protein kinase; neoplasm cells; ovarian neoplasms; plant ovary; proteins; protocatechuic acid; uterine neoplasms
Abstract:: ... A phytochemical study on the fruits of Schisandra chinensis led to the isolation and characterization of nineteen compounds. The structures of the isolates were determined to be schizandrin, deoxyschizandrin, angeloylgomisin H, gomisin A, gomisin J, (−)-gomisin L₁, (−)-gomisin L₂, wuweizisu C, gomisin N, meso-dihydroguaiaretic acid, kadsuphilactone B, α-ylangenol, α-ylangenyl acetate, β-chamigrena ...
DOI:: 10.1007/s12272-017-0902-5
: https://doi.org/10.1007/s12272-017-0902-5

93. LC-MS profiling highlights hazelnut (Nocciola di Giffoni PGI) shells as a byproduct rich in antioxidant phenolics

Author:: Milena Masullo; Antonietta Cerulli; Angela Mari; Carla Clisiane de Souza Santos; Cosimo Pizza; Sonia Piacente
Source:: Food research international 2017 v.101 pp. 180-187
ISSN:: 0963-9969
Subject:: 2,2-diphenyl-1-picrylhydrazyl; antioxidant activity; antioxidants; bioactive compounds; byproducts; cultivars; cytotoxicity; economic resources; fibroblasts; flavonoids; hazelnuts; humans; ionization; lignans; liquid chromatography; markets; mass spectrometry; methanol; monitoring; neoplasms; nuclear magnetic resonance spectroscopy; protected designation of origin; quantitative analysis
Abstract:: ... The Italian “Nocciola di Giffoni”, also known as “Tonda di Giffoni”, a labelled Protected Geographical Indication (PGI) product, represents an important economic resource for the Italian market. The methanol (MeOH) extract of “Tonda di Giffoni” shells has been investigated for the phenolic content, assayed by the Folin-Ciocalteu method, and for the antioxidant activity by the 1,1-diphenyl-2-picryl ...
DOI:: 10.1016/j.foodres.2017.08.063
: https://doi.org/10.1016/j.foodres.2017.08.063

94. Lignan glycosides from the Rhizomes of Smilax trinervula and their Biological activities

Author:: Jicheng Shu; Fang Liang; Genhua Zhu; Xing Liu; Jiangli Yu; Huilian Huang
Source:: Phytochemistry letters 2017 v.20 pp. 1-8
ISSN:: 1874-3900
Subject:: Smilax; cytotoxicity; electrospray ionization mass spectrometry; glycosides; humans; inhibitory concentration 50; lignans; neoplasm cells; nuclear magnetic resonance spectroscopy; rhizomes; spectral analysis
Abstract:: ... Phytochemical investigation of the rhizomes of Smilax trinervula led to isolation and structure elucidation of eight lignan glycosides, including five new lignans, namely, (7S, 8R, 8′R)-4, 4′, 9-trihydroxy-3, 3′, 5, 5′-tetramethoxy-7, 9′-epoxylignan-7′-one 4′-O-β-d-glucopyranoside (1), (7S, 8R, 8′R)-4, 4′, 9-trihydroxy-3, 3′, 5, 5′-tetramethoxy-7, 9′-epoxylignan-7′-one 4-O-β-d- glucopyranoside (2) ...
DOI:: 10.1016/j.phytol.2017.03.002
: https://doi.org/10.1016/j.phytol.2017.03.002

95. Lignans and diterpenes isolated from Tirpitzia ovoidea and their biological activities

Author:: Xue-Yan YANG; Yi-Fan ZHANG; Li-Jia LIU; Yi WANG; Ming-Ying SHANG; Feng XU; Guang-Xue LIU; Shao-Qing CAI
Source:: Chinese journal of natural medicines 2017 v.15 no.12 pp. 938-943
ISSN:: 1875-5364
Subject:: Linaceae; Oriental traditional medicine; aerial parts; anti-inflammatory activity; cell lines; cytotoxicity; diterpenoids; ethanol; ethyl acetate; inflammation; inhibitory concentration 50; lignans; macrophages; mice; models; nitric oxide; spectral analysis
Abstract:: ... A new lignan, tirpitzin A (17) together with 20 known compounds (1–16, and 18–21) were isolated from the ethyl acetate soluble fraction of ethanol extract of the aerial parts of Tirpitzia ovoidea. The structure of new compound was elucidated by means of spectroscopic analysis. Of the known compounds, 7–21 were isolated from Linaceae family for the first time. The pharmacological activity of the cr ...
DOI:: 10.1016/S1875-5364(18)30010-4
: https://doi.org/10.1016/S1875-5364(18)30010-4

96. Lignans and indole alkaloids from the seeds of Centaurea vlachorum Hartvig (Asteraceae), growing wild in Albania and their biological activity

Author:: Entela Hodaj; Olga Tsiftsoglou; Sokol Abazi; Dimitra Hadjipavlou-Litina; Diamanto Lazari
Source:: Natural product research 2017 v.31 no.10 pp. 1195-1200
ISSN:: 1478-6427
Subject:: Centaurea; linoleic acid; seeds; bioactive properties; serotonin; 2,2-diphenyl-1-picrylhydrazyl; linoleate 13S-lipoxygenase; soybeans; free radical scavengers; secondary metabolites; indole alkaloids; lignans; in vitro studies; peroxidation; matairesinol; Albania
Abstract:: ... The present phytochemical investigation of the seeds of Centaurea vlachorum led to the isolation and characterisation of four compounds including two indole alkaloids N-(p-coumaroyl) serotonin (1) and moschamine (2) and two dibenzylbutyrolactone lignans matairesinol (3) and arctiin (4). This is the first report on the isolation of non-volatile secondary metabolites from C. vlachorum. The chemataxo ...
DOI:: 10.1080/14786419.2016.1226823
: https://doi.org/10.1080/14786419.2016.1226823

97. Lignans from Opuntia ficus-indica seeds protect rat primary hepatocytes and HepG2 cells against ethanol-induced oxidative stress

Author:: Jung Wha Kim; Heejung Yang; Hyeon Woo Kim; Hong Pyo Kim; Sang Hyun Sung
Source:: Bioscience, biotechnology, and biochemistry 2017 v.81 no.1 pp. 181-183
ISSN:: 1347-6947
Subject:: Opuntia ficus-indica; biotechnology; glutathione; heme oxygenase (biliverdin-producing); hepatocytes; lignans; oxidative stress; rats; reactive oxygen species
Abstract:: ... Bioactivity-guided isolation of Opuntia ficus-indica (Cactaceae) seeds against ethanol-treated primary rat hepatocytes yielded six lignan compounds. Among the isolates, furofuran lignans 4−6, significantly protected rat hepatocytes against ethanol-induced oxidative stress by reducing intracellular reactive oxygen species levels, preserving antioxidative defense enzyme activities, and maintaining t ...
DOI:: 10.1080/09168451.2016.1234930
: https://doi.org/10.1080/09168451.2016.1234930

98. Lignans from a wild vegetable (Patrinina villosa) able to combat Alzheimer’s disease

Author:: Ming Bai; Guo-Dong Yao; Si-Fan Liu; Di Wang; Qing-Bo Liu; Xiao-Xiao Huang; Shao-Jiang Song
Source:: Journal of functional foods 2017 v.28 pp. 106-113
ISSN:: 1756-4646
Subject:: Alzheimer disease; active ingredients; antioxidants; chemical structure; ethanol; functional foods; green leafy vegetables; lignans; molecular models; neuroprotective effect; salads; soups; spectral analysis; tetrahydrofuran; China; Japan; Korean Peninsula; North America
Abstract:: ... Patrinina villosa Juss. is a delicious wild vegetable, which is widely distributed in China, Korea, Japan and North America. P. villosa, which smells fresh and is highly nutritious, can be made into a salad, used as greens and as a porridge and soup. Phytochemical investigation of the 70% EtOH extract showed the presence of two dibenzylbutyrolactone lignans (1–2), named Patrinians (A-B), along wit ...
DOI:: 10.1016/j.jff.2016.10.024
: https://doi.org/10.1016/j.jff.2016.10.024

99. Lignans from guaiac resin decrease nitric oxide production in interleukin 1β-treated hepatocytes

Author:: Yuki Nakano; Masaaki Nasu; Mana Kano; Hiroshi Kameoka; Tetsuya Okuyama; Mikio Nishizawa; Yukinobu Ikeya
Source:: Natural medicines 2017 v.71 no.1 pp. 190-197
ISSN:: 1340-3443
Subject:: Guaiacum officinale; anti-inflammatory activity; drugs; heartwood; hepatocytes; interleukin-1beta; lignans; monitoring; nitric oxide; rats
Abstract:: ... Guaiac resin, extracted from the heartwood of Guaiacum officinale L. or G. sanctum L., is speculated to have anti-inflammatory effects. Lignans were purified from guaiac resin (also known as gum guaiacum) by monitoring the nitric oxide (NO) production in rat hepatocytes treated with an inflammatory cytokine interleukin-1β (IL-1β). Six lignans were purified from guaiac resin and identified as: dehy ...
DOI:: 10.1007/s11418-016-1048-3
: https://doi.org/10.1007/s11418-016-1048-3

100. Lignans from the Roots of Taxus wallichiana and Their α-Glucosidase Inhibitory Activities

Author:: Dang Phu H.; Nguyen Hai X.; Nguyen Hanh H. T.; Vo Thai D.; Le Tho H.; Phan Trong H. N.; Nguyen Mai T. T.; Nguyen Nhan T.
Source:: Journal of natural products 2017 v.80 no.6 pp. 1876-1882
ISSN:: 1520-6025
Subject:: Taxus wallichiana; alpha-glucosidase; inhibitory concentration 50; lignans; roots; spectral analysis
Abstract:: ... From an EtOAc-soluble extract of the roots of Taxus wallichiana, six new (1–6) and 11 known lignans were isolated. The structures of the new compounds were elucidated based on interpretation of spectroscopic data. (+)-7′-epi-Tsugacetal (1) is a rare aryltetralin-type lignan having a cis-orientation of H-7′ and H-8′. Compounds 3–6 were identified as the first naturally occurring tetrahydrofuranoid ...
DOI:: 10.1021/acs.jnatprod.7b00171
: https://doi.org/10.1021/acs.jnatprod.7b00171

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1. (-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1

2. Absorption, distribution, metabolism, and excretion of [14C]sesamin in rats

3. Alashinols F and G, two lignans from stem bark of Syringa pinnatifolia

4. Almond Polyphenols: Methods of Analysis, Contribution to Food Quality, and Health Promotion

5. Anti-biofilm activity against Staphylococcus aureus MRSA and MSSA of neolignans and extract of Piper regnellii

6. Anti-complementary constituents of Anchusa italica

7. Anti-inflammatory effects of Forsythia suspensa in dextran sulfate sodium-induced colitis

8. Anti-inflammatory neolignans from Epimedium pseudowushanese

9. Anti-neuroinflammatory asarone derivatives from the rhizomes of Acorus tatarinowii

10. Antibacterial neolignans from the leaves of Melaleuca bracteata

11. Antidiabetic effect of gomisin N via activation of AMP-activated protein kinase

12. Antioxidant and antimicrobial activity of linseed lignans and phenolic acids

13. Antioxidant and cytotoxic lignans from the roots of Bupleurum chinense

14. Antiplasmodial Securinega alkaloids from Phyllanthus fraternus: Discovery of natural (+)-allonorsecurinine

15. Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome

16. Arctigenin represses TGF-β-induced epithelial mesenchymal transition in human lung cancer cells

17. Arctigenin suppresses renal interstitial fibrosis in a rat model of obstructive nephropathy

18. Association between Urinary Phytoestrogens and C-reactive Protein in the Continuous National Health and Nutrition Examination Survey

19. Association between polyphenol intake and adherence to the Mediterranean diet in Sicily, southern Italy

20. Associations between Both Lignan and Yogurt Consumption and Cardiovascular Risk Parameters in an Elderly Population: Observations from a Cross-Sectional Approach in the PREDIMED Study

21. Asymmetric synthesis of furofurans

22. Bifidobacterium adolescentis INIA P784: The first probiotic bacterium capable of producing enterodiol from lignan extracts

23. Bioactive Asarone-Derived Phenylpropanoids from the Rhizome of Acorus tatarinowii Schott

24. Bioactive Glycosides from the Twigs of Litsea cubeba

25. Bioactive lignans and flavones with in vitro antioxidant and neuroprotective properties from Rubus idaeus rhizome

26. Bioactive lignans from the stems of Mappianthus iodoides

27. Bioactive phenolics from in vitro cultures of Lactuca aculeata Boiss. et Kotschy

28. Bioactive phytochemicals in barley

29. The Breast Cancer Resistance Protein (BCRP/ABCG2) influences the levels of enterolignans and their metabolites in plasma, milk and mammary gland

30. Can sesame consumption improve blood pressure? A systematic review and meta‐analysis of controlled trials

31. Changes in phenolic composition in olive tree parts according to development stage

32. Characterization of Phase I and Phase II Hepatic Metabolism and Reactive Intermediates of Larrea nitida Cav. and Its Lignan Compounds

33. Characterization of some potential medicinal plants from Central Europe by their antioxidant capacity and the presence of metal elements

34. Chemical Composition and Immuno‐Modulatory Effects of Urtica dioica L. (Stinging Nettle) Extracts

35. Chemical Composition and UVA-Protecting Activity of Extracts from Ligustrum vulgare and Olea europaea Leaves

36. Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa

37. Chemical constituents from Piper boehmeriifolium (Miq.) Wall. ex C. DC

38. Chemical profiling and antioxidant evaluation of Yangxinshi Tablet by HPLC–ESI-Q-TOF-MS/MS combined with DPPH assay

39. Chemical study of Anthospermum emirnense (Rubiaceae)

40. Chiral separation and chemical profile of Dengzhan Shengmai by integrating comprehensive with multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

41. Comparative analysis of the in-vitro antioxidant activity and bioactive compounds of flaxseed in China according to variety and geographical origin

42. Comprehensive profiling and characterization of chemical constituents of rhizome of Anemarrhena asphodeloides Bge.

43. Configuration and stability of naturally occurring all-cis-tetrahydrofuran lignans from Piper solmsianum

44. The Contents of Lignans in Sesame Seeds and Commercial Sesame Oils of China

45. Cytotoxic neolignans from the traditional Chinese medicine Daphniphyllum macropodum Miq.

46. Derivatives of the Lignan 7′-Hydroxymatairesinol with Antioxidant Properties and Enhanced Lipophilicity

47. Diacylglycerol acyltransferase 1 (DGAT1) inhibition by furofuran lignans from stems of Acanthopanax senticosus

48. Diarylpropanes and lignans from Horsfieldia tetratepala

49. Dibenzocyclooctadiene lignans from Kadsura heteroclita

50. Differential effects of in vitro cultures of Linum usitatissimum L. (Flax) on biosynthesis, stability, antibacterial and antileishmanial activities of zinc oxide nanoparticles: a mechanistic approach

51. Differential responses of Scots pine stilbene synthase and chalcone synthase genes to Heterobasidion annosum infection

52. Direct study of minor extra-virgin olive oil components without any sample modification. 1H NMR multisupression experiment: A powerful tool

53. Diterpenoids and Lignans from Cephalotaxus fortunei

54. Effect of Antibiotics and Diet on Enterolactone Concentration and Metabolome Studied by Targeted and Nontargeted LC–MS Metabolomics

55. Effect of Sesamin Supplementation on Glycemic Status, Inflammatory Markers, and Adiponectin Levels in Patients with Type 2 Diabetes Mellitus

56. Effects of photoperiod regimes and ultraviolet-C radiations on biosynthesis of industrially important lignans and neolignans in cell cultures of Linum usitatissimum L. (Flax)

57. Enantiomeric 8-O-4′ type neolignans from red raspberry as potential inhibitors of β-amyloid aggregation

58. Ent-kaurene diterpenoids and lignan from Leontopodium leontopodioides and their inhibitory activities against cyclooxygenases-1 and 2

59. Enumeration of carboxyl groups carried on individual components of humic systems using deuteromethylation and Fourier transform mass spectrometry

60. Evaluation of antioxidant activity, total phenolics, total flavonoids and LC–MS/MS characterisation of phenolic constituents in Stachys lavandulifolia

61. Evaluation of phenolic profile and antioxidant capacity in gluten-free flours

62. Expression in Pichia pastoris and characterization of two novel dirigent proteins for atropselective formation of gossypol

63. Extraction of Flaxseed Oil: A Comparative Study of Three-Phase Partitioning and Supercritical Carbon Dioxide Using Response Surface Methodology

64. Extraction of bioactive compounds from sesame (Sesamum indicum L.) defatted seeds using water and ethanol under sub-critical conditions

65. Fargesin exerts anti-inflammatory effects in THP-1 monocytes by suppressing PKC-dependent AP-1 and NF-ĸB signaling

66. Flavonol glycosides and lignans from the leaves of Opilia amentacea

67. Flaxseed and multigrain mixtures in the development of functional biscuits

68. Flaxseed secoisolariciresinol diglucoside (SDG) during lactation improves bone metabolism in offspring at adulthood

69. Four new neolignans isolated from Eleutherococcus senticosus and their protein tyrosine phosphatase 1B inhibitory activity (PTP1B)

70. Functional characterization of the pinoresinol–lariciresinol reductase-2 gene reveals its roles in yatein biosynthesis and flax defense response