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lignans
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- Author:
- Di Yang; Chen-Xi Xiao; Zheng-Hua Su; Meng-Wei Huang; Ming Qin; Wei-Jun Wu; Wan-Wan Jia; Yi-Zhun Zhu; Jin-Feng Hu; Xin-Hua Liu
- Source:
- Phytomedicine 2017 v.32 pp. 15-23
- ISSN:
- 0944-7113
- Subject:
- Western blotting; anti-inflammatory activity; antineoplastic activity; antioxidants; cardiovascular diseases; drugs; endothelial cells; fluorescent antibody technique; gene expression regulation; heme oxygenase (biliverdin-producing); inducible nitric oxide synthase; inflammation; interleukin-6; lignans; messenger RNA; mitogen-activated protein kinase; necrosis; pathogenesis; phosphorylation; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; superoxide dismutase; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Endothelial inflammation is an increasingly prevalent condition in the pathogenesis of many cardiovascular diseases. (-)-7(S)-hydroxymatairesinol (7-HMR), a naturally occurring plant lignan, possesses both antioxidant and anti-cancer properties and therefore would be a good strategy to suppress tumor necrosis factor-α (TNF-α)-mediated inflammation in vascular endothelial cells (VECs).: The objecti ...
- DOI:
- 10.1016/j.phymed.2017.04.005
- https://doi.org/10.1016/j.phymed.2017.04.005
- Author:
- Namino Tomimori; Tomohiro Rogi; Hiroshi Shibata
- Source:
- Molecular nutrition & food research 2017 v.61 no.8 pp. -
- ISSN:
- 1613-4125
- Subject:
- absorption; autoradiography; bile; carbon; cytochrome P-450; excretion; feces; half life; intestinal microorganisms; kidneys; lignans; liver; metabolites; oral administration; pharmacokinetics; radioactivity; radionuclides; rats; sesame seed; tissue distribution; urine
- Abstract:
- ... SCOPE: Sesamin is a major lignan in sesame seeds and has various physiological effects. Although metabolism of sesamin by cytochrome P450 or intestinal microflora has been reported, little is known concerning the mass balance, pharmacokinetics, and tissue distribution of sesamin. METHODS AND RESULTS: Absorption, distribution, metabolism, and excretion of [¹⁴C]sesamin were investigated after a sing ...
- DOI:
- 10.1002/mnfr.201600844
- https://doi.org/10.1002/mnfr.201600844
- Author:
- Xiao Feng; Guozhu Su; Yunyun Ye; Ruifei Zhang; Xinyao Yang; Bingzhao Du; Bing Peng; Pengfei Tu; Xingyun Chai
- Source:
- Natural product research 2017 v.31 no.13 pp. 1555-1560
- ISSN:
- 1478-6427
- Subject:
- Syringa; anti-inflammatory activity; bark; lignans; nuclear magnetic resonance spectroscopy; spectral analysis; traditional medicine
- Abstract:
- ... Two new lignans, alashinols F and G (1 and 2), together with two known analogues (−)-secoisolariciresinol (3) and meso -secoisolariciresinol (4) were isolated from the stem bark of Syringa pinnatifolia , a Mongolian folk medicine with anti-myocardial ischaemic effects. Their structures were elucidated on basis of spectroscopic data analyses, including MS and 1D and 2D NMR, and their absolute confi ...
- DOI:
- 10.1080/14786419.2017.1283500
- https://doi.org/10.1080/14786419.2017.1283500
- Author:
- Bradley W. Bolling
- Source:
- Comprehensive reviews in food science and food safety 2017 v.16 no.3 pp. 346-368
- ISSN:
- 1541-4337
- Subject:
- aldehydes; almonds; antioxidant activity; antioxidants; antiviral properties; astringency; blanching; food quality; health promotion; hydrolysis; ingredients; isoflavones; lignans; lipid composition; lipid peroxidation; pasteurization; pigmentation; proanthocyanidins; roasting; shelf life; solvents; stilbenes; tannins; ultraviolet radiation; vitamin E
- Abstract:
- ... Almond is a nutrient‐dense tree nut recognized for its favorable lipid profile, vitamin E content, and polyphenols. The objectives of this review were to determine the polyphenols reported in almond, summarize the methods of analysis, and determine the polyphenol contribution to almond quality and health‐promoting activity. Approximately 130 different polyphenols have been identified in almond, al ...
- DOI:
- 10.1111/1541-4337.12260
- https://doi.org/10.1111/1541-4337.12260
- Author:
- Lara Z.S. Brambilla; Eliana H. Endo; Diógenes A.G. Cortez; Benedito P. Dias Filho
- Source:
- Revista Brasileira de Farmacognosia 2017 v.27 no.1 pp. 112-117
- ISSN:
- 0102-695X
- Subject:
- Piper; antibiotic resistance; antimicrobial properties; biofilm; disease control; lignans; methicillin; methicillin-resistant Staphylococcus aureus; methylene chloride; minimum inhibitory concentration; plankton
- Abstract:
- ... Many infections worldwide are associated with bacterial biofilms. The effects of isolated neolignans (conocarpan and eupomathenoid-5) and the dichloromethane extract of Piper regnellii (Miq.) C. DC., Piperaceae, were tested against isolates of methicillin-resistant Staphylococcus aureus and methicillin-sensitive S. aureus biofilms and S. aureus planktonic cells. The dichloromethane extract present ...
- DOI:
- 10.1016/j.bjp.2016.08.008
- https://doi.org/10.1016/j.bjp.2016.08.008
- Author:
- Yu-zhen Hou; Kui-kui Chen; Xi-ling Deng; Ze-long Fu; Dao-feng Chen; Qi Wang
- Source:
- Natural product research 2017 v.31 no.21 pp. 2572-2574
- ISSN:
- 1478-6427
- Subject:
- Anchusa azurea; alcohols; alkaloids; complement; flavonoids; fractionation; lignans; triterpenoids
- Abstract:
- ... Activity-guided fractionation for complement inhibitors led to the isolation of 24 known compounds from Anchusa italica . Chemical types include eight megastigmane compounds, five triterpenoid compounds, five lignan compounds, three flavonoid compounds, two alkaloid compounds and one phenthyl alcohol compound. Among which, a lignan (medioresinol), an alkaloid (5-hydroxypyrrolidin-2-one) and a flav ...
- DOI:
- 10.1080/14786419.2017.1320789
- https://doi.org/10.1080/14786419.2017.1320789
- Author:
- Youn-Hwan Hwang; Dong-Gun Kim; Wei Li; Hye Jin Yang; Nam-Hui Yim; Jin Yeul Ma
- Source:
- Journal of ethnopharmacology 2017 v.206 pp. 73-77
- ISSN:
- 0378-8741
- Subject:
- Forsythia suspensa; Oriental traditional medicine; anti-inflammatory activity; body weight changes; colitis; colon; dextran sulfate; diarrhea; edema; epithelium; flavonoids; histopathology; inflammation; interleukin-6; lignans; necrosis; therapeutics; triterpenoids; tumor necrosis factor-alpha
- Abstract:
- ... Forsythia suspensa Fructus (FS) is used to treat various inflammatory disorders in traditional Oriental medicine, including gastrointestinal diseases, but its therapeutic potential in ulcerative colitis is unclear. Thus, we investigated any potential therapeutic effects of FS against intestinal inflammation and the bioactive constituents in FS.After the induction of colitis using 3% dextran sulfat ...
- DOI:
- 10.1016/j.jep.2017.05.011
- https://doi.org/10.1016/j.jep.2017.05.011
- Author:
- Huihui Ti; Ping Wu; Liangxiong Xu; Xiaoyi Wei
- Source:
- Natural product research 2017 v.31 no.22 pp. 2621-2628
- ISSN:
- 1478-6427
- Subject:
- Epimedium; anti-inflammatory activity; lignans; secretion; spectroscopy; tumor necrosis factor-alpha
- Abstract:
- ... One new 8- O -4′ neolignan has been isolated from Epimedium pseudowushanese B. L. Guo, together with nine other known neolignans. The structures of these neolignans were elucidated using spectroscopic and chemical techniques, and their anti-inflammatory activities were also evaluated. The results of these experiments revealed that compound 6 was the most potent of the 10 different compounds tested ...
- DOI:
- 10.1080/14786419.2017.1289200
- https://doi.org/10.1080/14786419.2017.1289200
- Author:
- Da-Peng Qin; Xiao-Lin Feng; Wei-Yang Zhang; Hao Gao; Xiao-Rui Cheng; Wen-Xia Zhou; Yang Yu; Xin-Sheng Yao
- Source:
- RSC advances 2017 v.7 no.14 pp. 8512-8520
- ISSN:
- 2046-2069
- Subject:
- Acorus gramineus; X-ray diffraction; cell lines; cytotoxicity; enantiomers; lignans; mice; neuroglia; rhizomes; spectroscopy; tumor necrosis factor-alpha
- Abstract:
- ... A novel 7-O-7′ type mesomeric neolignan, meso-asarolignan A (1), six pairs of new neolignan enantiomers, (±)-asarolignan B–G (2a/2b, 3a/3b, 4–6, 7a/7b), along with 16 known analogues (8–23) were isolated from the rhizomes of Acorus tatarinowii. The structures of the new compounds were elucidated by extensive analysis of spectroscopic, X-ray diffraction, and computational data. Compounds 1–3 repres ...
- DOI:
- 10.1039/c6ra27786a
- https://doi.org/10.1039/c6ra27786a
- Author:
- Can Li; Hongxin Liu; Liyun Zhao; Weimin Zhang; Shengxiang Qiu; Xiaoyun Yang; Haibo Tan
- Source:
- Fitoterapia 2017 v.120 pp. 171-176
- ISSN:
- 0367-326X
- Subject:
- Melaleuca; aldehydes; antibiotic resistance; antimicrobial properties; biochemical pathways; biomimetics; leaves; lignans; methicillin; methicillin-resistant Staphylococcus aureus; odors; spectral analysis
- Abstract:
- ... Phytochemical study on the leaves of Melaleuca bracteata resulted in the isolation of ten compounds including three new neolignans, named melaleucins A–C (1–3). Among them, melaleucin B shares a rarely occurring nor-neolignan skeleton, and both melaleucins B and C bear a novel aldehyde moiety, which might also be response for the delicate fragrance of M. bracteata. Their structures were extensivel ...
- DOI:
- 10.1016/j.fitote.2017.06.015
- https://doi.org/10.1016/j.fitote.2017.06.015
- Author:
- Dae Young Jung; Ji-Hyun Kim; Hoyoung Lee; Myeong Ho Jung
- Source:
- Biochemical and biophysical research communications 2017 pp. -
- ISSN:
- 0006-291X
- Subject:
- AMP-activated protein kinase; Schisandra chinensis; animal disease models; beta oxidation; biogenesis; blood glucose; fatty liver; genes; glucose; glucose tolerance; glucose transporters; glycemic effect; high fat diet; in vivo studies; insulin; lignans; metabolic syndrome; mice; mitochondria; myotubes; obesity; phosphorylation; plasma membrane; skeletal muscle
- Abstract:
- ... Gomisin N (GN) is a lignan derived from Schisandra chinensis. AMP-activated kinase (AMPK) has gained attention as a therapeutic target for the treatment of metabolic syndrome. Previously, we reported that GN activated the AMPK pathway and ameliorated high-fat diet (HFD)-induced hepatic steatosis. In this study, we investigated the anti-diabetic effects of GN in C2C12 myotubes and HFD obese mice. G ...
- DOI:
- 10.1016/j.bbrc.2017.10.120
- https://doi.org/10.1016/j.bbrc.2017.10.120
- Author:
- Jan Kyselka; Dobrochna Rabiej; Miroslav Dragoun; František Kreps; Zuzana Burčová; Irena Němečková; Jana Smolová; Marie Bjelková; Aleksandra Szydłowska-Czerniak; Štefan Schmidt; Luděk Šarman; Vladimír Filip
- Source:
- European food research & technology 2017 v.243 no.9 pp. 1633-1644
- ISSN:
- 1438-2377
- Subject:
- Gram-negative bacteria; Gram-positive bacteria; antimicrobial properties; antioxidants; bioactive compounds; caffeic acid; chromatography; ferulic acid; hydrolysis; levulinic acid; lignans; linseed; lipid peroxidation; mass spectrometry; median effective concentration; molds (fungi); oxidation; p-coumaric acid; pressing; reaction kinetics; secondary metabolites; solvents; stoichiometry; triacylglycerols; yeasts
- Abstract:
- ... In this study, we present antioxidant and antimicrobial activity of isolated lignans freed of other bioactive compounds in comparison with dominant phenolic acids. The combinations of screw pressing, solvent extractions, acid-catalysed hydrolysis and flash chromatography were used to describe and isolate linseed phenolic compounds. Secoisolariciresinol, ferulic, p-coumaric and caffeic acids were t ...
- DOI:
- 10.1007/s00217-017-2871-9
- https://doi.org/10.1007/s00217-017-2871-9
- Author:
- Dan-Qi Li; Di Wang; Le Zhou; Ling-Zhi Li; Qing-Bo Liu; Ying-Ying Wu; Jing-Yu Yang; Shao-Jiang Song; Chun-Fu Wu
- Source:
- Journal of Asian natural products research 2017 v.19 no.5 pp. 519-527
- ISSN:
- 1477-2213
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Bupleurum chinense; antioxidant activity; bioactive compounds; cytotoxicity; ethanol; fluorouracil; free radical scavengers; glucosides; inhibitory concentration 50; lignans; neoplasm cells; nuclear magnetic resonance spectroscopy; roots; spectral analysis
- Abstract:
- ... In the search for biologically active compounds from the roots of Bupleurum chinense D C., phytochemical investigation of its ethanol extract led to the isolation and identification of a new 8- O -4′ neolignan glucoside, saikolignanoside A (1), along with eight known lignans (2–9). Their structures were determined on the basis of IR, UV, HRESIMS, and NMR spectroscopic analyses. The antioxidant and ...
- DOI:
- 10.1080/10286020.2016.1234456
- https://doi.org/10.1080/10286020.2016.1234456
- Author:
- Gustav Komlaga; Grégory Genta-Jouve; Sandrine Cojean; Rita A. Dickson; Merlin L.K. Mensah; Philippe M. Loiseau; Pierre Champy; Mehdi A. Beniddir
- Source:
- Tetrahedron letters 2017 pp. -
- ISSN:
- 0040-4039
- Subject:
- Phyllanthus fraternus; Plasmodium falciparum; Securinega; alkaloids; antimalarials; antiparasitic properties; chemical reactions; chemical structure; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
- Abstract:
- ... The chemical investigation of the antimalarial plant Phyllanthus fraternus G. L. Webster (Phyllanthaceae) resulted in the discovery of the Securinega alkaloid (+)-allonorsecurinine (1), previously reported as a synthetic compound, together with the known ent-norsecurinine (2), nirurine (3), bubbialine (4), epibubbialine (5) and the lignan phyllanthin (6). The structure and absolute configuration o ...
- DOI:
- 10.1016/j.tetlet.2017.08.045
- https://doi.org/10.1016/j.tetlet.2017.08.045
- Author:
- Shimeng Zhang; Liangjun Jiang; Fengyuan Che; Yucheng Lu; Zhongxiang Xie; Hao Wang
- Source:
- Biochemical and biophysical research communications 2017 pp. -
- ISSN:
- 0006-291X
- Subject:
- Arctium lappa; brain; infarction; inflammasomes; interleukin-18; interleukin-1beta; ischemia; lignans; neuroprotective effect; protein synthesis; rats; secretion; signal transduction; stroke; surgery; water content
- Abstract:
- ... Arctigenin (ARC), a phenylpropanoid dibenzylbutyrolactone lignan derived from Arctium lappa L, has been reported to protect against cerebral ischemia injury in rats, but the underlying mechanism is unclear. In this study, we investigated whether ARC ameliorated ischemic stroke by inhibiting NLRP3 inflammasome-derived neuroinflammation and whether SIRT1 signaling was involved in this process. ARC ( ...
- DOI:
- 10.1016/j.bbrc.2017.08.062
- https://doi.org/10.1016/j.bbrc.2017.08.062
- Author:
- Yanrui Xu; Zhiyuan Lou; Seong-Ho Lee
- Source:
- Biochemical and biophysical research communications 2017 v.493 pp. 934-939
- ISSN:
- 0006-291X
- Subject:
- Asteraceae; antineoplastic activity; beta catenin; cadherins; dose response; epithelium; humans; lignans; lung neoplasms; metastasis; mitogen-activated protein kinase; models; neoplasm cells; phosphorylation; snails; toxicity; transcription (genetics)
- Abstract:
- ... Arctigenin (ARC) is a lignan that is abundant in Asteraceae plants, which show anti-inflammatory and anti-cancer activities. The current study investigated whether ARC affects cancer progression and metastasis, focusing on EMT using invasive human non-small cell lung cancer (NSCLC) cells. No toxicity was observed in the cells treated with different doses of ARC (12–100 μM). The treatment of ARC re ...
- DOI:
- 10.1016/j.bbrc.2017.09.117
- https://doi.org/10.1016/j.bbrc.2017.09.117
- Author:
- Ao Li; Xiaoxun Zhang; Mao Shu; Mingjun Wu; Jun Wang; Jingyao Zhang; Rui Wang; Peng Li; Yitao Wang
- Source:
- Phytomedicine 2017 v.30 pp. 28-41
- ISSN:
- 0944-7113
- Subject:
- Arctium lappa; animal disease models; anti-inflammatory activity; antioxidant activity; atrophy; chemokine CCL2; collagen; disease prevention; epithelium; fibrosis; fruits; furans; histology; inflammation; interferon-gamma; interleukin-1beta; kidney diseases; lignans; lipid peroxidation; macrophages; messenger RNA; oxidative stress; phytopharmaceuticals; protein phosphorylation; rats; renal tubules; renoprotective effect; superoxide dismutase; transcription factor NF-kappa B; transforming growth factor beta 1; tumor necrosis factor-alpha
- Abstract:
- ... Renal tubulointerstitial fibrosis (TIF) is commonly the final result of a variety of progressive injuries and leads to end-stage renal disease. There are few therapeutic agents currently available for retarding the development of renal TIF.The aim of the present study is to evaluate the role of arctigenin (ATG), a lignan component derived from dried burdock (Arctium lappa L.) fruits, in protecting ...
- DOI:
- 10.1016/j.phymed.2017.03.003
- https://doi.org/10.1016/j.phymed.2017.03.003
- Author:
- Michael K. Reger; Terrell W. Zollinger; Ziyue Liu; Josette Jones; Jianjun Zhang
- Source:
- Journal of the American College of Nutrition 2017 v.36 no.6 pp. 434-441
- ISSN:
- 1541-1087
- Subject:
- C-reactive protein; National Health and Nutrition Examination Survey; biomarkers; blood serum; cardiovascular diseases; confidence interval; inflammation; lignans; neoplasms; plant estrogens; risk; risk reduction; United States
- Abstract:
- ... Objective : A reduced risk of some cancers and cardiovascular disease associated with phytoestrogen intake may be mediated through its effect on serum C-reactive protein (CRP; an inflammation biomarker). Therefore, this study examined the associations between urinary phytoestrogens and serum CRP. Methods : Urinary phytoestrogen and serum CRP data obtained from 6009 participants aged ≥ 40 years in ...
- DOI:
- 10.1080/07315724.2017.1318722
- https://doi.org/10.1080/07315724.2017.1318722
- Author:
- Justyna Godos; Giuseppina Rapisarda; Stefano Marventano; Fabio Galvano; Antonio Mistretta; Giuseppe Grosso
- Source:
- NFS journal 2017 v.8 pp. 1-7
- ISSN:
- 2352-3646
- Subject:
- Mediterranean diet; adults; anthocyanins; apigenin; databases; dietary nutrient sources; eating habits; ferulic acid; food intake; hesperetin; lignans; matairesinol; myricetin; naringenin; polyphenols; questionnaires; regression analysis; traditional foods; urban areas; Italy; Sicily
- Abstract:
- ... Mediterranean diet has been demonstrated to exert beneficial effects toward various health outcomes. Among the compounds that may be responsible for such benefits, polyphenols have been proposed as potential candidates. The aim of this study was to evaluate whether dietary polyphenols were associated with adherence to the Mediterranean diet in a Sicilian cohort.A total of 1937 adults were recruite ...
- DOI:
- 10.1016/j.nfs.2017.06.001
- https://doi.org/10.1016/j.nfs.2017.06.001
- Author:
- Anna Creus-Cuadros; Anna Tresserra-Rimbau; Paola Quifer-Rada; Miguel Angel Martínez-González; Dolores Corella; Jordi Salas-Salvadó; Montse Fitó; Ramon Estruch; Enrique Gómez-Gracia; José Lapetra; Fernando Arós; Miquel Fiol; Emili Ros; Lluís Serra-Majem; Xavier Pintó; Juan José Moreno; Miguel Ruiz-Canela; Jose Vicente Sorli; Josep Basora; Helmut Schröder; Rosa Maria Lamuela-Raventós; PREDIMED Study Investigators
- Source:
- Journal of the Academy of Nutrition and Dietetics 2017 v.117 no.4 pp. 609-622.e1
- ISSN:
- 2212-2672
- Subject:
- biomarkers; blood pressure; body mass index; cardiovascular diseases; cross-sectional studies; dairy consumption; diet study techniques; eating habits; elderly; glucose; human health; lignans; linear models; low density lipoprotein cholesterol; men; risk; triacylglycerols; waist circumference; women; yogurt
- Abstract:
- ... The study of dietary patterns is gaining interest. Although the health benefits of yogurt and lignans have been investigated separately, to our knowledge there are no studies on their associative effects.The aim of this study was to evaluate a possible association between yogurt and lignans using biomarkers of cardiovascular disease risk in an elderly population.We conducted a cross-sectional anal ...
- DOI:
- 10.1016/j.jand.2016.11.003
- https://doi.org/10.1016/j.jand.2016.11.003