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- Author:
- Yoshio Fujita; Kazuyuki Hirai; Keigo Nishida; Hiroaki Taguchi
- Source:
- Amino acids 2016 v.48 no.5 pp. 1319-1329
- ISSN:
- 0939-4451
- Subject:
- Influenza A virus; Toll-like receptor 7; Toll-like receptor 8; agonists; amino acids; antibodies; antigens; ligands; mice; peptides; pharmacology; subunit vaccines; vaccine adjuvants
- Abstract:
- ... Generally, small peptides by themselves are weak to induce antibody responses. Toll-like receptor (TLR) ligands are attractive candidates of vaccine adjuvants to improve their antigenicity. The covalent conjugation of TLR ligands with antigens to produce self-adjuvanting peptide vaccine is a promising approach. Based on the structure of TLR7/8 ligands, a series of synthetic amino acids 6-imidazoqu ...
- DOI:
- 10.1007/s00726-016-2190-7
- https://doi.org/10.1007/s00726-016-2190-7
- Author:
- Jennifer Mullin; Muhammed S. Ahmed; Ravi Sharma; Navdeep Upile; Helen Beer; Priya Achar; Suttida Puksuriwong; Francesca Ferrara; Nigel Temperton; Paul McNamara; Teresa Lambe; Sarah C. Gilbert; Qibo Zhang
- Source:
- Vaccine 2016 v.34 no.14 pp. 1688-1695
- ISSN:
- 0264-410X
- Subject:
- CD4-positive T-lymphocytes; Influenza A virus; antibodies; antigens; hemagglutinins; humans; immunity; influenza; nucleoproteins; pandemic; vaccine development; vaccines; vertebrate viruses
- Abstract:
- ... Recent efforts have been focused on the development of vaccines that could induce broad immunity against influenza virus, either through T cell responses to conserved internal antigens or B cell response to cross-reactive haemagglutinin (HA). We studied the capacity of Modified Vaccinia Ankara (MVA)-vectored influenza vaccines to induce cross-reactive immunity to influenza virus in human nasophary ...
- DOI:
- 10.1016/j.vaccine.2016.02.028
- https://doi.org/10.1016/j.vaccine.2016.02.028
- Author:
- Yongkun Zhao; Zhijun Yu; Linna Liu; Tiecheng Wang; Weiyang Sun; Chengyu Wang; Zhiping Xia; Yuwei Gao; Bo Zhou; Jun Qian; Xianzhu Xia
- Source:
- Veterinary microbiology 2016 v.187 pp. 8-14
- ISSN:
- 0378-1135
- Subject:
- Influenza A virus; amino acid substitution; amino acids; genome; humans; mice; proteins; virulence; viruses
- Abstract:
- ... To identify molecular features that confer enhanced H7N9 virulence in mammals, we independently generated three mouse-adapted variants of A/Shanghai/2/2013 (H7N9) by serial passage in mice. The mouse lethal doses (MLD50) of the mouse-adapted variants were reduced >1000–100000-fold when compared to the parental virus. Adapted variants displayed enhanced replication kinetics in vivo, and were capabl ...
- DOI:
- 10.1016/j.vetmic.2016.02.027
- https://doi.org/10.1016/j.vetmic.2016.02.027
- Author:
- Kateri Bertran; Dong-Hun Lee; Charles Balzli; Mary J. Pantin-Jackwood; Erica Spackman; David E. Swayne
- Source:
- Veterinary research 2016 v.47 no.1 pp. 116
- ISSN:
- 1297-9716
- Subject:
- Influenza A virus; White Leghorn; avian influenza; biosecurity; broiler breeders; death; eggs; farms; genetic resistance; lethal dose; mortality; pathogenesis; pathogenicity; turkeys; viral shedding; viruses; United States
- Abstract:
- ... In 2014–2015, the US experienced an unprecedented outbreak of H5 clade 2.3.4.4 highly pathogenic avian influenza (HPAI) virus. The H5N2 HPAI virus outbreak in the Midwest in 2015 affected commercial turkey and layer farms, but not broiler farms. To assess any potential genetic resistance of broilers and/or age-related effects, we investigated the pathogenesis and transmission of A/turkey/Minnesota ...
- DOI:
- 10.1186/s13567-016-0401-6
- PubMed:
- 27871330
- PubMed Central:
- PMC5117617
- CHORUS:
- 10.1186/s13567-016-0401-6
- https://doi.org/10.1186/s13567-016-0401-6
- Author:
- Kateri Bertran; Dong-Hun Lee; Charles Balzli; Mary J. Pantin-Jackwood; Erica Spackman; David E. Swayne
- Source:
- Veterinary research 2016 v.47 no.1 pp. 116-127
- ISSN:
- 1297-9716
- Subject:
- Influenza A virus; White Leghorn; animal age; avian influenza; biosecurity; broiler breeders; death; disease outbreaks; disease resistance; disease transmission; eggs; farms; genetic resistance; lethal dose; mortality; pathogenesis; pathogenicity; turkeys; viral shedding; viruses; Midwestern United States
- Abstract:
- ... In 2014–2015, the US experienced an unprecedented outbreak of H5 clade 2.3.4.4 highly pathogenic avian influenza (HPAI) virus. The H5N2 HPAI virus outbreak in the Midwest in 2015 affected commercial turkey and layer farms, but not broiler farms. To assess any potential genetic resistance of broilers and/or age-related effects, we investigated the pathogenesis and transmission of A/turkey/Minnesota ...
- Handle:
- 10113/5729149
- DOI:
- DOI 10.1186/s13567-016-0401-6
- PubMed:
- 27871330
- PubMed Central:
- PMC5117617
- https://doi.org/DOI 10.1186/s13567-016-0401-6
- Author:
- Fabien Gueugnon; Virginie C. Thibault; Jennifer Kearley; Agnès Petit-Courty; Amandine Vallet; Antoine Guillon; Mustapha Si-Tahar; Alison A. Humbles; Yves Courty
- Source:
- Gene 2016 v.586 no.1 pp. 176-183
- ISSN:
- 0378-1119
- Subject:
- Gram-negative bacteria; Haemophilus influenzae; Influenza A virus; bacterial infections; cigarettes; gene expression; genes; inflammation; lipopolysaccharides; lipoteichoic acids; lungs; messenger RNA; mice; morbidity; mortality; proteins; respiratory tract diseases; smoking (habit)
- Abstract:
- ... The CCN proteins are key signaling and regulatory molecules involved in many biological functions and contribute to malignant and non-malignant lung diseases. Despite the high morbidity and mortality of the lung respiratory infectious diseases, there is very little data related to the expression of the CCNs during infection. We investigated in mice the pulmonary mRNA expression levels of five CCNs ...
- DOI:
- 10.1016/j.gene.2016.04.022
- https://doi.org/10.1016/j.gene.2016.04.022
- Author:
- Xiuming Peng; Haibo Wu; Xiaorong Peng; Xiaoxin Wu; Linfang Cheng; Fumin Liu; Shujing Ji; Nanping Wu
- Source:
- Archives of virology 2016 v.161 no.6 pp. 1665-1670
- ISSN:
- 0304-8608
- Subject:
- Influenza A virus; amino acid substitution; human health; mice; mortality; pathogenicity; poultry industry; viral load; viruses
- Abstract:
- ... Avian influenza viruses (AIVs) are known to cross species barriers, and emergent highly pathogenic H5N6 AIVs pose a serious threat to human health and the poultry industry. Here, we serially passaged an H5N6 virus 10 times in BALB/c mice. The pathogenicity of the wild-type 6D2 (WT-6D2) and mammal-adapted 6D2 strain (MA-6D2) were compared. The viral titer in multiple organs and the death rate for M ...
- DOI:
- 10.1007/s00705-016-2826-7
- https://doi.org/10.1007/s00705-016-2826-7
- Author:
- Yutaka Sasaki; Naoto Yoshino; Shigehiro Sato; Yasushi Muraki
- Source:
- Journal of virological methods 2016 v.235 pp. 105-111
- ISSN:
- 0166-0934
- Subject:
- Influenza A virus; hemagglutinins; human influenza; humans; pH; vaccine development; virion; viruses
- Abstract:
- ... Beta-propiolactone (BPL) is used as an inactivating reagent for influenza virus in a number of countries. However, the treatment of viruses with BPL occasionally results in a decrease in the hemagglutinin (HA) titer, which complicates vaccine development. In the present study, we examined the biological and biochemical characteristics of human H1N1 and H3N2 viruses treated with BPL, and developed ...
- DOI:
- 10.1016/j.jviromet.2016.04.013
- https://doi.org/10.1016/j.jviromet.2016.04.013
- Author:
- Huilin Ou; Hangping Yao; Wei Yao; Nanping Wu; Xiaoxin Wu; Chengcong Han; Linfang Cheng; Keda Chen; Honglin Chen; Lanjuan Li
- Source:
- Vaccine 2016 v.34 no.20 pp. 2362-2370
- ISSN:
- 0264-410X
- Subject:
- Influenza A virus; adjuvants; alum; antibodies; antibody formation; antigens; avian influenza; bioactive properties; clinical trials; cytokines; genes; genetics; hemagglutinins; humans; humoral immunity; immunoglobulin G; manufacturing; mice; morbidity; mortality; sialidase; vaccines; viruses; China
- Abstract:
- ... The H7N9 influenza virus caused significant mortality and morbidity in humans during an outbreak in China in 2013. A recombinant H7N9 influenza seed with hemagglutinin (HA) and neuraminidase (NA) gene segments from A/Zhejiang/DTID-ZJU01/2013(H7N9) and six internal protein gene segments from A/Puerto Rico/8/34(H1N1; PR8) were generated using reverse genetics. We sought to determine the immunogenic, ...
- DOI:
- 10.1016/j.vaccine.2016.03.037
- https://doi.org/10.1016/j.vaccine.2016.03.037
- Author:
- Xiao-peng Hu; Min-ming Shao; Xun Song; Xu-li Wu; Ling Qi; Kai Zheng; Long Fan; Cheng-hui Liao; Chen-yang Li; Jiang He; Ying-jie Hu; Hai-qiang Wu; Shi-he Li; Jian Zhang; Feng-xue Zhang; Zhen-dan He
- Source:
- Journal of ethnopharmacology 2016 v.179 pp. 128-136
- ISSN:
- 0378-8741
- Subject:
- Influenza A virus; Ligustrum robustum subsp. chinense; Western blotting; antiviral properties; cytokines; flow cytometry; glycosides; hemagglutination; interferon-gamma; knockout mutants; liquid petroleum gas; lymphocytes; medicinal plants; mice; oral administration; secretion; spleen; survival rate; tea; traditional medicine; viral load; viruses; China
- Abstract:
- ... Ligustrum purpurascens Y.C. Yang (Oleaceae) is traditionally recorded as “Ku Ding Cha”, a kind of functional tea in southern China for about two thousand years, which has been reported with sore throat alleviating and pathogenic heat expelling effects. However, there are no scientific studies demonstrating its antiviral activity.This study is aimed at investigating the anti-influenza virus effects ...
- DOI:
- 10.1016/j.jep.2015.07.019
- https://doi.org/10.1016/j.jep.2015.07.019
- Author:
- Guinn Kayla; Fojtik Alinde; Davis-Fields Nick; Poulson Rebecca L.; Krauss Scott; Webster Robert G.; Stallknecht David E.
- Source:
- Avian diseases 2016 v.60 no.1s pp. 341-345
- ISSN:
- 0005-2086
- Subject:
- Influenza A virus; Laridae; Limulus polyphemus; beaches; direct contact; ducks; eggs; enzyme-linked immunosorbent assay; habitats; hemagglutination; neutralizing antibodies; serology; seroprevalence; viruses; Delaware Bay; United States
- Abstract:
- ... Gulls are the known reservoir for H13 and H16 influenza A viruses (IAV) but also host a diversity of other IAV subtypes. Gulls also share habitats with both ducks and shorebirds, increasing the potential for cross-species IAV transmission. We serologically tested laughing gulls (Leucophaeus atricilla) collected at Delaware Bay during May when they were in direct contact with IAV-infected shorebird ...
- DOI:
- 10.1637/11103-042115-Reg
- https://doi.org/10.1637/11103-042115-Reg
- Author:
- Bailey Elizabeth; Long Li-Ping; Zhao Nan; Hall Jeffrey S.; Baroch John A.; Nolting Jacqueline; Senter Lucy; Cunningham Frederick L.; Pharr G. Todd; Hanson Larry; Slemons Richard; DeLiberto Thomas J.; Wan Xiu-Feng
- Source:
- Avian diseases 2016 v.60 no.1s pp. 346-353
- ISSN:
- 0005-2086
- Subject:
- Influenza A virus; antigenic variation; antiserum; chickens; dogs; ferrets; hemagglutination; horses; hosts; human population; humans; migratory birds; swine; viruses; waterfowl; North America
- Abstract:
- ... Besides humans, H3 subtypes of influenza A viruses (IAVs) can infect various animal hosts, including avian, swine, equine, canine, and sea mammal species. These H3 viruses are both antigenically and genetically diverse. Here, we characterized the antigenic diversity of contemporary H3 avian IAVs recovered from migratory birds in North America. Hemagglutination inhibition (HI) assays were performed ...
- DOI:
- 10.1637/11086-041015-RegR
- PubMed:
- 27309078
- PubMed Central:
- PMC4911812
- https://doi.org/10.1637/11086-041015-RegR
- Author:
- O. A. Adeola; B. O. Olugasa; B. O. Emikpe
- Source:
- Zoonoses and public health 2016 v.63 no.2 pp. 106-111
- ISSN:
- 1863-1959
- Subject:
- Influenza A virus; antigen detection; cities; early warning systems; enzyme-linked immunosorbent assay; hemagglutinins; humans; influenza; monoclonal antibodies; nose; pandemic; swine; vertebrate viruses; viruses; Ghana; Nigeria
- Abstract:
- ... Since the first detection of human H3N2 influenza virus in Taiwanese pigs in 1970, infection of pigs with wholly human viruses has been known to occur in other parts of the world. These viruses, referred to as human‐like H3N2 viruses, have been known to cause clinical and subclinical infections of swine populations. Due to the paucity and complete unavailability of information on transmission of i ...
- DOI:
- 10.1111/zph.12210
- https://doi.org/10.1111/zph.12210
- Author:
- Yandi Wei; Guanlong Xu; Guozhong Zhang; Chu Wen; Furkat Anwar; Shuoguo Wang; Gordon Lemmon; Jinliang Wang; Robert Carter; Min Wang; Honglei Sun; Yipeng Sun; Jixun Zhao; Gang Wu; Robert G. Webster; Jinhua Liu; Juan Pu
- Source:
- Veterinary microbiology 2016 v.182 pp. 1-7
- ISSN:
- 0378-1135
- Subject:
- Influenza A virus; amino acid composition; amino acid sequences; antigenic variation; chickens; cross reaction; evolution; genetic techniques and protocols; hemagglutination; hemagglutinins; influenza; monitoring; mutation; neutralization tests; nucleotide sequences; polyclonal antibodies; vaccines; viral shedding; viruses; China
- Abstract:
- ... We previously demonstrated that H9N2 subtype avian influenza viruses (AIVs) isolated from 1994 to 2008 evolved into distinct antigenic groups (C, D, and E) and then underwent antigenic drift from commercial vaccines, causing a country-wide outbreak during 2010–2013. In this study, H9N2 AIVs isolated from chickens during 2009–2013 were antigenically analyzed by performing hemagglutination inhibitio ...
- DOI:
- 10.1016/j.vetmic.2015.10.031
- PubMed:
- 26711021
- PubMed Central:
- PMC5029119
- https://doi.org/10.1016/j.vetmic.2015.10.031
- Author:
- Lv Xiao-Jing; Li Yong; Ma Shuang-Gang; Qu Jing; Liu Yun-Bao; Li Yu-Huan; Zhang Dan; Li Li; Yu Shi-Shan
- Source:
- Journal of natural products 2016 v.79 no.11 pp. 2824-2837
- ISSN:
- 1520-6025
- Subject:
- inhibitory concentration 50; Enterovirus; nuclear magnetic resonance spectroscopy; X-ray diffraction; antiviral properties; Human alphaherpesvirus 1; Influenza A virus; triterpenoids; leaves; spectral analysis; branches; herpes simplex; Lyonia ovalifolia; glycosides; circular dichroism spectroscopy
- Abstract:
- ... Eleven new 9,10-seco-cycloartan triterpene glycosides (1–11), seven new lanostane triterpene glycosides (12–18), and two new ursane triterpenoids (19–20) were isolated from the twigs and leaves of Lyonia ovalifolia. The structures of these compounds were elucidated by extensive MS and NMR spectroscopic analysis. The absolute configuration of compound 1a (the aglycone of 1) was established by X-ray ...
- DOI:
- 10.1021/acs.jnatprod.6b00585
- https://doi.org/10.1021/acs.jnatprod.6b00585
- Author:
- Sunghee Bang; Thi Kim Quy Ha; Changyeol Lee; Wei Li; Won-Keun Oh; Sang Hee Shim
- Source:
- Journal of ethnopharmacology 2016 v.192 pp. 398-405
- ISSN:
- 0378-8741
- Subject:
- Influenza A virus; Salvia plebeia; aerial parts; antiviral agents; antiviral properties; chemical structure; chloroform; chromatography; common cold; cough; cytopathogenicity; enzyme inhibition; ethyl acetate; flavonoids; food plants; glycosides; hepatitis; hydrolysates; influenza; inhibitory concentration 50; monoterpenoids; rosmarinic acid; sesquiterpenoids; sialidase; spectral analysis; stereochemistry; traditional medicine; triterpenoids
- Abstract:
- ... Salvia plebeia R. Br. is an edible plant widely spread in many countries. It has been used as a traditional medicine to treat common cold, flu, cough, hepatitis, hemorrhoids, etc. The purpose of the study is to explicate antiviral compounds responsible for its traditional use for the common cold or flu.The methanolic extract of the aerial parts of S. plebeia was extracted with CHCl3, EtOAc, and n- ...
- DOI:
- 10.1016/j.jep.2016.09.030
- https://doi.org/10.1016/j.jep.2016.09.030
- Author:
- Andrea Derksen; Joachim Kühn; Wali Hafezi; Jandirk Sendker; Christina Ehrhardt; Stephan Ludwig; Andreas Hensel
- Source:
- Journal of ethnopharmacology 2016 v.188 pp. 144-152
- ISSN:
- 0378-8741
- Subject:
- Eupatorium perfoliatum; Influenza A virus; aerial parts; antiviral properties; cell viability; cytopathogenicity; cytotoxicity; dogs; epidermal growth factor; epithelium; fever; flavonoids; fractionation; glycosides; hemagglutination; human cell lines; inhibitory concentration 50; kidneys; liquid chromatography; lungs; mass spectrometry; mechanism of action; methanol; methylene chloride; mitogen-activated protein kinase; molecular weight; phytotherapy; polyphenols; quinic acid; signal transduction; solvents; traditional medicine; tumor necrosis factor-alpha; viruses; Europe
- Abstract:
- ... Aerial parts of Eupatorium perfoliatum have been traditionally used by American natives as a treatment for fever and infections. Also modern phytotherapy in Europe documents the use of hydroalcoholic extracts of this herbal material for the treatment of infections of the upper respiratory tract.The aim of the present study was to characterize the anti-influenza A virus (IAV) potential of extracts ...
- DOI:
- 10.1016/j.jep.2016.05.016
- https://doi.org/10.1016/j.jep.2016.05.016
- Author:
- Shuang-Gang Ma; Ya Gao; Hui-Qiang Wang; Li Li; Yun-Bao Liu; Jing Qu; Yong Li; Song Xu; Hai-Ning Lv; Yu-Huan Li; Shi-Shan Yu
- Source:
- Tetrahedron 2016 v.72 pp. 3003-3013
- ISSN:
- 0040-4020
- Subject:
- Illicium oligandrum; Influenza A virus; X-ray diffraction; antiviral properties; chemical reactions; chemical structure; chloroform; inhibitory concentration 50; nuclear magnetic resonance spectroscopy; roots; spectral analysis
- Abstract:
- ... Four new bis-prenylated C6–C3 derivatives, illioliganpyranones B–C (1 and 4) and illioliganfuranones E–F (3 and 5), and six new mono-prenylated C6–C3 compounds, illioliganfuranone G (2), illioliganfuranol A (6), illioliganpyranone D (7), illioliganones J–K (8 and 9), and illioliganpyranol A (10), were isolated from the CHCl3 extract of Illicium oligandrum roots. The structures of 1–10 were determi ...
- DOI:
- 10.1016/j.tet.2016.04.016
- https://doi.org/10.1016/j.tet.2016.04.016
- Author:
- Michał Jóźwiak; Krzysztof Wyrostek; Katarzyna Domańska-Blicharz; Monika Olszewska-Tomczyk; Krzysztof Śmietanka; Zenon Minta
- Source:
- Journal of Veterinary Research 2016 v.60 no.1 pp. 1-6
- ISSN:
- 2450-8608
- Subject:
- Influenza A virus; RNA; adsorption; ambient temperature; chickens; detection limit; pathogenicity; reverse transcriptase polymerase chain reaction; viruses
- Abstract:
- ... Introduction: The aim of the study was to test the utility of Flinders Technology Associates filter paper (FTA® Cards) for molecular detection and storage of avian influenza virus (AIV). Material and Methods: There were two strains of AIV used in the study: low pathogenicity H7N1 and high pathogenicity H5N1 subtypes. Detection of viral material was conducted using molecular RT-PCR and rRT- PCR met ...
- DOI:
- 10.1515/jvetres-2016-0001
- https://doi.org/10.1515/jvetres-2016-0001
- Author:
- P. Netrabukkana; I. D. Robertson; S. Kasemsuwan; K. Wongsathapornchai; S. Fenwick
- Source:
- Transboundary and emerging diseases 2016 v.63 no.1 pp. e135
- ISSN:
- 1865-1674
- Subject:
- Influenza A virus; biosecurity; boars; chickens; disease prevention; emerging diseases; farmers; farms; fertilizers; herds; hiring; humans; interviews; issues and policy; monitoring; production technology; public health; questionnaires; risk; surveys; swine diseases; swine production; virus transmission; viruses; Thailand
- Abstract:
- ... Influenza A viruses pose a major public health threat worldwide, especially due to the potential for inter‐species transmission. Farmers could be among the first people to be infected with a novel reassortant virus in a pig herd and may serve as a source of the virus for their communities. In this study, the pig production systems of smallholders in rural Thailand were examined to qualitatively ev ...
- DOI:
- 10.1111/tbed.12226
- https://doi.org/10.1111/tbed.12226
- Author:
- Lang Andrew S.; Lebarbenchon Camille; Ramey Andrew M.; Robertson Gregory J.; Waldenström Jonas; Wille Michelle
- Source:
- Avian diseases 2016 v.60 no.1s pp. 378-386
- ISSN:
- 0005-2086
- Subject:
- Influenza A virus; Laridae; Uria aalge; Uria lomvia; data collection; ecology; hemagglutinins; influenza; lifestyle; nucleotide sequences; seabirds; viruses; waterfowl
- Abstract:
- ... Wild waterbirds, specifically waterfowl, gulls, and shorebirds, are recognized as the primordial reservoir of influenza A viruses (IAVs). However, the role of seabirds, an abundant, diverse, and globally distributed group of birds, in the perpetuation and transmission of IAVs is less clear. Here we summarize published and publicly available data for influenza viruses in seabirds, which for the pur ...
- DOI:
- 10.1637/11135-050815-RegR
- https://doi.org/10.1637/11135-050815-RegR
- Author:
- Benjamin J. Cowling; Shuo Feng; Lyn Finelli; Andrea Steffens; Ashley Fowlkes
- Source:
- Vaccine 2016 v.34 no.1 pp. 61-66
- ISSN:
- 0264-410X
- Subject:
- Influenza A virus; children; disease outbreaks; elderly; influenza; laboratory experimentation; monitoring; odds ratio; patients; vaccination; vaccines; United States
- Abstract:
- ... Influenza vaccines are now widely used to reduce the burden of annual epidemics of influenza virus infections. Influenza vaccine effectiveness (VE) is monitored annually to determine VE against each season's circulating influenza strains in different groups such as children, adults and the elderly. Few prospective surveillance programs are available to evaluate influenza VE against medically atten ...
- DOI:
- 10.1016/j.vaccine.2015.11.016
- PubMed:
- 26611200
- PubMed Central:
- PMC4889456
- https://doi.org/10.1016/j.vaccine.2015.11.016
- Author:
- Śmietanka Krzysztof; Bocian Łukasz; Meissner Włodzimierz; Ziętek-Barszcz Anna; Żółkoś Katarzyna
- Source:
- Avian diseases 2016 v.60 no.1s pp. 316-321
- ISSN:
- 0005-2086
- Subject:
- Anas platyrhynchos; Influenza A virus; autumn; ducks; models; pathogenicity; risk assessment; spring; viruses
- Abstract:
- ... This work presents the results of studies aimed at assessing the median and maximum distances covered by wild mallards (Anas platyrhynchos; n = 38), hypothetically infected with the high pathogenicity avian influenza virus (HPAIV) during spring migrations, using GPS-GSM tracking and published data on the susceptibility to HPAIV infection and duration of shedding. The model was based on the assumpt ...
- DOI:
- 10.1637/11080-040715-RegR
- https://doi.org/10.1637/11080-040715-RegR
- Author:
- Sentíes-Cué C. Gabriel; Gallardo Rodrigo A.; Reimers Nancy; Bickford Arthur A.; Charlton Bruce R.; Shivaprasad H. L.
- Source:
- Avian diseases 2016 v.60 no.2 pp. 511-515
- ISSN:
- 0005-2086
- Subject:
- Eastern equine encephalitis virus; Influenza A virus; West Nile virus; Western equine encephalitis virus; business enterprises; cerebellum; eggs; encephalitis; flocks; fowl pox; head; histopathology; legs; mortality; neurons; peripheral nerves; pullets; reverse transcriptase polymerase chain reaction; specific pathogen-free animals; spinal cord; vaccination; viruses; Central Valley of California
- Abstract:
- ... Avian encephalomyelitis (AE) was diagnosed in three flocks of leghorn layer pullets following AE vaccination. Ages of the birds were 11, 12, and 14 wk. The submissions came from three different companies located in two geographic areas of the Central Valley of California. The clinical signs included birds down on their legs, unilateral recumbency or sitting on their hocks, lethargy, reluctance to ...
- DOI:
- 10.1637/11306-102115-Case
- https://doi.org/10.1637/11306-102115-Case
- Author:
- Marta Ferenczi; Christa Beckmann; Simone Warner; Richard Loyn; Kim O’Riley; Xinlong Wang; Marcel Klaassen
- Source:
- Veterinary research 2016 v.47 no.1 pp. 23
- ISSN:
- 1297-9716
- Subject:
- El Nino; Influenza A virus; avian influenza; breeding; climatic factors; ducks; feces; humans; juveniles; long term effects; rain; temperature; viruses; waterfowl; wild birds; wildlife; Australia
- Abstract:
- ... Understanding Avian Influenza Virus (AIV) infection dynamics in wildlife is crucial because of possible virus spill over to livestock and humans. Studies from the northern hemisphere have suggested several ecological and environmental drivers of AIV prevalence in wild birds. To determine if the same drivers apply in the southern hemisphere, where more irregular environmental conditions prevail, we ...
- DOI:
- 10.1186/s13567-016-0308-2
- PubMed:
- 26852115
- PubMed Central:
- PMC4744453
- https://doi.org/10.1186/s13567-016-0308-2
- Author:
- Feng-Min Xi; Yun-Bao Liu; Jing Qu; Yong Li; Zhong-Hai Tang; Li Li; Yu-Huan Li; Xiao-Guang Chen; Shuang-Gang Ma; Shi-Shan Yu
- Source:
- Tetrahedron 2016 pp. -
- ISSN:
- 0040-4020
- Subject:
- Artabotrys hexapetalus; Enterovirus; Influenza A virus; antiviral properties; chemical reactions; circular dichroism spectroscopy; cytotoxicity; high performance liquid chromatography; inhibitory concentration 50; roots; sesquiterpenoids; stereoisomers
- Abstract:
- ... Seven pairs of sesquiterpenes (1a/1b–7a/7b), a new peroxy-bridge sesquiterpene (8), and a new peroxy-bridge norsesquiterpene (9), together with five known compounds, were isolated from the roots of Artabotrys hexapetalus. Their structures with absolute configurations were elucidated based on extensive spectroscopic analysis, especially the modified Mosher's method, and electronic circular dichrois ...
- DOI:
- 10.1016/j.tet.2016.12.043
- https://doi.org/10.1016/j.tet.2016.12.043
- Author:
- Elinor Willis; Kaela Parkhouse; Florian Krammer; Scott E. Hensley
- Source:
- Vaccine 2016 v.34 no.46 pp. 5483-5487
- ISSN:
- 0264-410X
- Subject:
- Influenza A virus; animal models; antibodies; birds; dogs; hemagglutinins; horses; influenza vaccines; mice; sterilizing immunity; viral proteins; viruses; United States
- Abstract:
- ... Influenza A viruses infect many species and cross-species transmission occurs occasionally. An equine H3N8 influenza virus began circulating in dogs in 1999 and an avian H3N2 influenza virus began circulating in dogs in 2006. The canine H3N8 (cH3N8) viral strain has become endemic in parts of the United States and there is a commercially available vaccine against this strain. The canine H3N2 (cH3N ...
- DOI:
- 10.1016/j.vaccine.2016.09.017
- PubMed:
- 27670073
- PubMed Central:
- PMC5075513
- https://doi.org/10.1016/j.vaccine.2016.09.017
- Author:
- Alexis Avril; Vladimir Grosbois; Neus Latorre‐Margalef; Nicolas Gaidet; Conny Tolf; Björn Olsen; Jonas Waldenström
- Source:
- Journal of applied ecology 2016 v.53 no.4 pp. 1289-1297
- ISSN:
- 0021-8901
- Subject:
- Anas platyrhynchos; Influenza A virus; adults; autumn; disease prevalence; ducks; hosts; juveniles; migratory behavior; models; monitoring; prediction; public health; risk; seasonal variation; stopover sites; viruses; wild birds; wildlife; Sweden
- Abstract:
- ... Disease prevalence in wildlife is governed by epidemiological parameters (infection and recovery rates) and response to infection, both of which vary within and among individual hosts. Studies quantifying these individual‐scale parameters and documenting their source of variation in wild hosts are fundamental for predicting disease dynamics. Such studies do not exist for the influenza A virus (IAV ...
- DOI:
- 10.1111/1365-2664.12699
- https://doi.org/10.1111/1365-2664.12699
- Author:
- Edsel Alves Beuttemmüller; Alana Woodward; Adam Rash; Luis Eduardo dos Santos Ferraz; Alice Fernandes Alfieri; Amauri Alcindo Alfieri; Debra Elton
- Source:
- Virology journal 2016 v.13 no.1 pp. 45
- ISSN:
- 1743-422X
- Subject:
- Influenza A virus; amino acid sequences; amino acid substitution; antigenic variation; antigens; antiserum; binding sites; eggs; equine influenza; ferrets; genes; hemagglutination; hemagglutinins; horses; nucleotide sequences; phylogeny; sequence analysis; sialic acids; sialidase; vaccines; viruses; Argentina; Brazil; Chile; Florida; Kentucky; Uruguay
- Abstract:
- ... BACKGROUND: An extensive outbreak of equine influenza occurred across multiple countries in South America during 2012. The epidemic was first reported in Chile then spread to Brazil, Uruguay and Argentina, where both vaccinated and unvaccinated animals were affected. In Brazil, infections were widespread within 3months of the first reported cases. Affected horses included animals vaccinated with o ...
- DOI:
- 10.1186/s12985-016-0503-9
- PubMed:
- 26993620
- PubMed Central:
- PMC4799594
- https://doi.org/10.1186/s12985-016-0503-9
- Author:
- Jun Liu; Feng Huang; Junsong Zhang; Likai Tan; Gen Lu; Xu Zhang; Hui Zhang
- Source:
- Virus genes 2016 v.52 no.3 pp. 346-353
- ISSN:
- 0920-8569
- Subject:
- Influenza A virus; amino acid composition; avian influenza; genes; humans; mixed infection; mutation; pandemic; phylogeny; ribonucleoproteins; viruses; China
- Abstract:
- ... Human coinfection with a novel H7N9 influenza virus and the 2009 pandemic A(H1N1) influenza virus, H1N1pdm09, has recently been reported in China. Because reassortment can occur during coinfection, it is necessary to clarify the effects of gene reassortment between these two viruses. Among the viral ribonucleoprotein complex (vRNP) genes, only the PA gene of H1N1pdm09 enhances the avian influenza ...
- DOI:
- 10.1007/s11262-016-1311-4
- https://doi.org/10.1007/s11262-016-1311-4
- Author:
- Xiao Wang; Feifei Meng; Dandan Wang; Xing Liu; Sujuan Chen; Tao Qin; Daxin Peng; Xiufan Liu
- Source:
- Archives of virology 2016 v.161 no.12 pp. 3365-3374
- ISSN:
- 0304-8608
- Subject:
- Influenza A virus; amino acid substitution; avian influenza; chickens; erythrocytes; geese; genetic background; genetic markers; growth models; hemagglutination; hosts; mice; microbial growth; virulence; viruses
- Abstract:
- ... Novel reassortant influenza A (H5N8) viruses are becoming a potential threat not only to the poultry industry but also to public health. Many molecular markers for pathogenicity in mammalian hosts have been identified in other H5 subtype avian influenza viruses (AIVs). However, the pathogenicity of H5N8 AIVs to mammals remains unclear. It is believed that selection of a pair of isolates with a sim ...
- DOI:
- 10.1007/s00705-016-3043-0
- https://doi.org/10.1007/s00705-016-3043-0
- Author:
- Jaakko Hiidenhovi; Christine Ek-Kommonen; Eila Järvenpää; Rainer Huopalahti; Eeva-Liisa Ryhänen
- Source:
- European food research & technology 2016 v.242 no.2 pp. 233-246
- ISSN:
- 1438-2377
- Subject:
- hemagglutination; antiviral properties; sialic acids; Influenza A virus; hydrolysates; ovomucin; food research; ultracentrifugation; Avian orthoavulavirus 1; enzymatic hydrolysis; gels; egg albumen
- Abstract:
- ... Structurally, egg white (EW) is composed of four distinct layers: outer thin white, thick white, inner thin white and chalaziferous layer (including chalaza cords). In addition, the thick white can be further separated into a gel and a liquid fraction by using ultracentrifugation. There were large differences in the amounts of various ovomucin complex forms between the EW layers, but more or less ...
- DOI:
- 10.1007/s00217-015-2535-6
- https://doi.org/10.1007/s00217-015-2535-6
- Author:
- Zaira Rehman; Rehan Zafar; Uzma Amir; Umer H. K. Niazi; Ammad Fahim
- Source:
- VirusDis. 2016 v.27 no.1 pp. 34-40
- ISSN:
- 2347-3584
- Subject:
- Influenza A virus; binding properties; genome; hemagglutinins; therapeutics
- Abstract:
- ... Influenza virus continues to evolve due to changes in the genome and the new strain of virus is more pathogenic then the previous strain. These changes may also help the virus to cross specie barrier and may also affect the binding pattern of virus.The main theme of the current study is the identification of changes in the hemagglutinin sequence of H1N1 virus from 1960 to 2011 and also how these c ...
- DOI:
- 10.1007/s13337-015-0294-4
- PubMed:
- 26925442
- PubMed Central:
- PMC4758314
- https://doi.org/10.1007/s13337-015-0294-4
- Author:
- Mei Qin; Xinming Tang; Guangwen Yin; Xianyong Liu; Jingxia Suo; Geru Tao; Saeed EI-Ashram; Yuan Li; Xun Suo
- Source:
- Parasites & vectors 2016 v.9 no.1 pp. 164
- ISSN:
- 1756-3305
- Subject:
- Eimeria mitis; Influenza A virus; adverse effects; antigens; chickens; coccidiosis; coccidiostats; financial economics; genetically modified organisms; immune response; immunoglobulin G; immunoglobulin Y; mammals; oocysts; pathogens; poultry industry; vaccination; vaccines; yolk sac
- Abstract:
- ... BACKGROUND: Eimeria species are obligate intracellular apicomplexan parasites, causing great economic losses in the poultry industry. Currently wild-and attenuated- type anticoccidial vaccines are used to control coccidiosis. However, their use in fast growing broilers is limited by vaccination side effects caused by medium and/or low immunogenic Eimeria spp. There is, therefore, a need for a vacc ...
- DOI:
- 10.1186/s13071-016-1451-3
- PubMed:
- 27000834
- PubMed Central:
- PMC4802925
- https://doi.org/10.1186/s13071-016-1451-3
- Author:
- Efstathios S. Giotis; Rebecca C. Robey; Natalie G. Skinner; Christopher D. Tomlinson; Stephen Goodbourn; Michael A. Skinner
- Source:
- Veterinary research 2016 v.47 no.1 pp. 75
- ISSN:
- 1297-9716
- Subject:
- Influenza A virus; chickens; chicks; embryo (animal); fibroblasts; humans; interferon-alpha; meat; microarray technology; sequence analysis; structural genes; transcriptome; transcriptomics; viruses
- Abstract:
- ... Viruses that infect birds pose major threats—to the global supply of chicken, the major, universally-acceptable meat, and as zoonotic agents (e.g. avian influenza viruses H5N1 and H7N9). Controlling these viruses in birds as well as understanding their emergence into, and transmission amongst, humans will require considerable ingenuity and understanding of how different species defend themselves. ...
- DOI:
- 10.1186/s13567-016-0363-8
- PubMed:
- 27494935
- PubMed Central:
- PMC4974698
- https://doi.org/10.1186/s13567-016-0363-8
- Author:
- Tao Cheng; Xiang Wang; Yufeng Song; Xinying Tang; Chao Zhang; Hongbo Zhang; Xia Jin; Dongming Zhou
- Source:
- Vaccine 2016 v.34 no.41 pp. 4875-4883
- ISSN:
- 0264-410X
- Subject:
- Influenza A virus; Pan troglodytes; avian influenza; birds; cell-mediated immunity; genome; hemagglutinins; humans; lungs; mice; mutation; neutralizing antibodies; pandemic; serotypes; vaccines; viral load; viruses
- Abstract:
- ... Highly pathogenic avian H5N1 viruses may give rise to the next influenza pandemic due to their reassortment and mutation of the genome. Vaccine against this virus is important for coping with its potential threat. Chimpanzee adenovirus (Ad) vectors are a novel type of vaccine vectors that share the advantages of human serotype Ad vectors but without being affected by pre-existing human neutralizin ...
- DOI:
- 10.1016/j.vaccine.2016.08.066
- https://doi.org/10.1016/j.vaccine.2016.08.066
37. Circulation of multiple genotypes of H1N2 viruses in a swine farm in Italy over a two-month period
- Author:
- Maria Serena Beato; Luca Tassoni; Adelaide Milani; Annalisa Salviato; Guido Di Martino; Monica Mion; Lebana Bonfanti; Isabella Monne; Simon James Watson; Alice Fusaro
- Source:
- Veterinary microbiology 2016 v.195 pp. 25-29
- ISSN:
- 0378-1135
- Subject:
- Influenza A virus; breeding; disease control; finishing; genetic variation; genome; genotype; hemagglutinins; livestock and meat industry; monitoring; nose; pandemic; piglets; sequence analysis; sows; vaccination; vaccines; viruses; Italy
- Abstract:
- ... In August 2012 repeated respiratory outbreaks caused by swine influenza A virus (swIAV) were registered for a whole year in a breeding farm in northeast Italy that supplied piglets for fattening. The virus, initially characterized in the farm, was a reassortant Eurasian avian-like H1N1 (H1avN1) genotype, containing a haemagglutinin segment derived from the pandemic H1N1 (A(H1N1)pdm09) lineage. To ...
- DOI:
- 10.1016/j.vetmic.2016.08.015
- https://doi.org/10.1016/j.vetmic.2016.08.015
- Author:
- L. Wei; Y. Song; J. Cui; N. Qu; N. Wang; G. Ouyang; M. Liao; P. Jiao
- Source:
- Poultry science 2016 v.95 no.10 pp. 2290-2296
- ISSN:
- 0032-5791
- Subject:
- Anser cygnoides; Influenza A virus; amino acid sequences; brain; caspases; geese; gene expression; genes; heart; immune response; innate immunity; jejunum; kidneys; liver; lungs; melanoma; physiology; polypeptides; quantitative polymerase chain reaction; restriction endonucleases; retinoic acid; spleen; stomach
- Abstract:
- ... Laboratory of genetics and physiology 2 (LGP2) is a homologue of the retinoic acid inducible gene-I and melanoma differentiation associated gene 5 that lacks the caspase activation and recruitment domain required for signaling. It plays a pivotal role in host immune response. In this study, we cloned and characterized the full-length open reading frame (ORF) sequence of LGP2 in the Qingyuan goose ...
- DOI:
- 10.3382/ps/pew162
- https://doi.org/10.3382/ps/pew162
- Author:
- Anna Stachyra; Patrycja Redkiewicz; Piotr Kosson; Anna Protasiuk; Anna Góra-Sochacka; Grzegorz Kudla; Agnieszka Sirko
- Source:
- Virology journal 2016 v.13 no.1 pp. 143
- ISSN:
- 1743-422X
- Subject:
- chickens; antigens; humans; hosts; Influenza A virus; swans; nucleotides; proteolysis; vaccination; codons; gene expression; hemagglutinins; animal models; immune response; mice; pandemic; influenza; recombinant vaccines
- Abstract:
- ... BACKGROUND: Highly pathogenic avian influenza viruses are a serious threat to domestic poultry and can be a source of new human pandemic and annual influenza strains. Vaccination is the main strategy of protection against influenza, thus new generation vaccines, including DNA vaccines, are needed. One promising approach for enhancing the immunogenicity of a DNA vaccine is to maximize its expressio ...
- DOI:
- 10.1186/s12985-016-0599-y
- PubMed:
- 27562235
- PubMed Central:
- PMC5000471
- https://doi.org/10.1186/s12985-016-0599-y
- Author:
- L.A. Reperant; I.H. Brown; O.L. Haenen; M.D. de Jong; A.D.M.E. Osterhaus; A. Papa; E. Rimstad; J.-F. Valarcher; T. Kuiken
- Source:
- Journal of comparative pathology 2016 v.155 no.1 pp. S41
- ISSN:
- 0021-9975
- Subject:
- Rotavirus; ornamental fish; Classical swine fever virus; reptiles; Chiroptera; ferrets; Cyprinid herpesvirus 3; Rift Valley fever phlebovirus; Lumpy skin disease virus; animal production; society; California encephalitis orthobunyavirus; Orthohepevirus A; Bluetongue virus; Infectious pancreatic necrosis virus; risk analysis; Cowpox virus; human health; Kobuvirus; viruses; carnivores; people; Tick-borne encephalitis virus; vertebrate viruses; Small ruminant morbillivirus; humans; cats; Orthohantavirus; dogs; pets; Crimean-Congo hemorrhagic fever orthonairovirus; Porcine circovirus; guinea pigs; birds; swine; Equine infectious anemia virus; Rabies lyssavirus; African swine fever virus; Influenza A virus; West Nile virus; Viral hemorrhagic septicemia virus; Lymphocytic choriomeningitis mammarenavirus; Equid alphaherpesvirus 9; food production; Foot-and-mouth disease virus; horses
- Abstract:
- ... Companion animals comprise a wide variety of species, including dogs, cats, horses, ferrets, guinea pigs, reptiles, birds and ornamental fish, as well as food production animal species, such as domestic pigs, kept as companion animals. Despite their prominent place in human society, little is known about the role of companion animals as sources of viruses for people and food production animals. Th ...
- DOI:
- 10.1016/j.jcpa.2016.07.006
- https://doi.org/10.1016/j.jcpa.2016.07.006
- Author:
- Kilany Walid H.; Bazid Abdel-Hamid I.; Ali Ahmed; El-Deeb Ayman H.; El-Abideen Mohamed A. Zain; Sayed Magdy El; El-Kady Magdy F.
- Source:
- Avian diseases 2016 v.60 no.1s pp. 226-231
- ISSN:
- 0005-2086
- Subject:
- Influenza A virus; adjuvants; antigens; avian influenza; broiler chickens; eggs; financial economics; hemagglutination; hemagglutination inhibition test; mixed infection; mortality; oils; pathogens; poultry industry; risk; vaccination; vaccines; viral shedding
- Abstract:
- ... Low pathogenic avian influenza H9N2 virus infection has been an important risk to the Egyptian poultry industry since 2011. Economic losses have occurred from early infection and co-infection with other pathogens. Therefore, H9N2 vaccination of broiler chicks as young as 7 days old was recommended. The current inactivated H9N2 vaccines (0.5 ml/bird) administered at a reduced dose (0.25 ml/bird) do ...
- DOI:
- 10.1637/11145-050815-Reg
- https://doi.org/10.1637/11145-050815-Reg
- Author:
- Rebecca Kinsley; Simon D. Scott; Janet M. Daly
- Source:
- Veterinary microbiology 2016 v.187 pp. 15-20
- ISSN:
- 0378-1135
- Subject:
- Influenza A virus; antibodies; blood serum; enzyme-linked immunosorbent assay; equine influenza; hemagglutination; hemolysis; horses; markets; monitoring; neutralization tests; pathogens; serology; vaccines
- Abstract:
- ... Serological assays provide an indirect route for the recognition of infectious agents via the detection of antibodies against the infectious agent of interest within serum. Serological assays for equine influenza A virus can be applied for different purposes: diagnosing infections; subtyping isolates; surveillance of circulating strains; and to evaluate the efficacy of vaccines before they reach t ...
- DOI:
- 10.1016/j.vetmic.2016.03.006
- https://doi.org/10.1016/j.vetmic.2016.03.006
- Author:
- Ichiyama Koji; Yang Chuan; Chandrasekaran Lakshmi; Liu Shaoqiong; Rong Lijun; Zhao Yue; Gao Shujun; Lee Ashlynn; Ohba Kenji; Suzuki Youichi; Yoshinaka Yoshiyuki; Shimotohno Kunitada; Miyakawa Kei; Ryo Akihide; Hedrick James; Yamamoto Naoki; Yang Yi Yan
- Source:
- Macromolecules 2016 v.49 no.7 pp. 2618-2629
- ISSN:
- 1520-5835
- Subject:
- electrostatic interactions; mammals; receptors; median effective concentration; virus replication; drug resistance; Ebolavirus; molecular models; DNA; amino acids; viruses; variance; mutation; mannose; hydrogen bonding; viral morphology; neutralization; polymers; antiviral properties; Marburg marburgvirus; Influenza A virus; Chikungunya virus; pH; Enterovirus A; Dengue virus; surface proteins; RNA; moieties
- Abstract:
- ... Treatment of viral infections continues to be elusive owing to the variance in virus structure (RNA, DNA, and enveloped and nonenveloped viruses) together with their ability to rapidly mutate and garner resistance. Here we report a general strategy to prevent viral infection using multifunctional macromolecules that were designed to have mannose moieties that compete with viruses for immune cells, ...
- DOI:
- 10.1021/acs.macromol.6b00091
- https://doi.org/10.1021/acs.macromol.6b00091
- Author:
- Shaohua Shi; Sujuan Chen; Weizhou Han; Bai Wu; Xiaojian Zhang; Ying Tang; Xiao Wang; Yinbiao Zhu; Daxin Peng; Xiufan Liu
- Source:
- Vaccine 2016 v.34 no.3 pp. 350-357
- ISSN:
- 0264-410X
- Subject:
- Influenza A virus; avian influenza; chickens; cross immunity; financial economics; immune response; mice; poultry industry; proteins; vaccination; vaccines; virus replication; viruses
- Abstract:
- ... H5N1 highly pathogenic avian influenza (HPAI) has raised global concern for causing huge economic losses in poultry industry, and an effective vaccine against HPAI is highly desirable. Live attenuated influenza vaccine with trunctated NS1 protein as a potential strategy will be extremely useful for improving immune efficacy.A series of H5N1 avian influenza virus reassortants harboring amino-termin ...
- DOI:
- 10.1016/j.vaccine.2015.11.045
- https://doi.org/10.1016/j.vaccine.2015.11.045
- Author:
- D. J. Hicks; M. Kelly; S. M. Brookes; B. Z. Londt; A. Ortiz Pelaez; A. Orlowska; I. H. Brown; Y. I. Spencer; A. Núñez
- Source:
- Transboundary and emerging diseases 2016 v.63 no.1 pp. e71
- ISSN:
- 1865-1674
- Subject:
- Influenza A virus; gene expression; gene expression regulation; humans; influenza; interferon-gamma; interleukin-10; interleukin-8; lungs; messenger RNA; models; pandemic; pathogenesis; reverse transcriptase polymerase chain reaction; swine; viruses
- Abstract:
- ... Pandemic influenza A(H1N1)pdm09 virus has retained its ability to infect swine whilst developing the ability to transmit effectively between humans, thus making the pig a valuable model for studying disease pathogenesis in both species. Lung lesions in pigs caused by infection with influenza A viruses vary in both their severity and distribution with individual lung lobes exhibiting lesions at dif ...
- DOI:
- 10.1111/tbed.12232
- https://doi.org/10.1111/tbed.12232
- Author:
- Shirene M. Singh; Tamiru N. Alkie; Éva Nagy; Raveendra R. Kulkarni; Douglas C. Hodgins; Shayan Sharif
- Source:
- Vaccine 2016 v.34 no.40 pp. 4807-4813
- ISSN:
- 0264-410X
- Subject:
- Influenza A virus; Toll-like receptors; adjuvants; agonists; antibodies; antibody affinity; chickens; emulsions; encapsulation; hemagglutination; immunoglobulin Y; nanoparticles; oligodeoxyribonucleotides; vaccination; vaccines; viral shedding; viruses
- Abstract:
- ... In poultry, systemic administration of commercial vaccines consisting of inactivated avian influenza virus (AIV) requires the simultaneous delivery of an adjuvant (water-in-oil emulsion). These vaccines are often limited in their ability to induce quantitatively better local (mucosal) antibody responses capable of curtailing virus shedding. Therefore, more efficacious adjuvants with the ability to ...
- DOI:
- 10.1016/j.vaccine.2016.08.009
- https://doi.org/10.1016/j.vaccine.2016.08.009
- Author:
- EunJung Lee; Eun-Ju Kim; Yeun-Kyung Shin; Jae-Young Song
- Source:
- Journal of virological methods 2016 v.228 pp. 114-122
- ISSN:
- 0166-0934
- Subject:
- Influenza A virus; amino acids; animals; cost effectiveness; disease transmission; genome; genomics; host specificity; hosts; hybridization probes; influenza; oligonucleotides; phylogeny; rapid methods; reverse transcriptase polymerase chain reaction; viruses
- Abstract:
- ... The avian influenza A virus causes respiratory infections in animal species. It can undergo genomic recombination with newly obtained genetic material through an interspecies transmission. However, the process is an unpredictable event, making it difficult to predict the emergence of a new pandemic virus and distinguish its origin, especially when the virus is the result of multiple infections. Th ...
- DOI:
- 10.1016/j.jviromet.2015.11.012
- https://doi.org/10.1016/j.jviromet.2015.11.012
- Author:
- Yongqiang Wang; Jiuxin Qu; Qi Ba; Jiuhong Dong; Liang Zhang; Hong Zhang; Aiping Wu; Dayan Wang; Zanxian Xia; Daxin Peng; Yuelong Shu; Bin Cao; Taijiao Jiang
- Source:
- Journal of virological methods 2016 v.234 pp. 178-185
- ISSN:
- 0166-0934
- Subject:
- DNA; Influenza A virus; avian influenza; birds; detection limit; genes; hemagglutinins; humans; messenger RNA; reverse transcriptase polymerase chain reaction; sialidase; transcription (genetics); viruses; China
- Abstract:
- ... Rapid identification of the infections of specific subtypes of influenza viruses is critical for patient treatment and pandemic control. Here we report the application of multiplex reverse transcription polymerase chain reaction (RT-PCR) coupled with membrane-based DNA biochip to the detection and discrimination of the type (A and B) and subtype (human H1N1, human H3N2, avian H5N1 and avian H7N9) ...
- DOI:
- 10.1016/j.jviromet.2016.04.021
- https://doi.org/10.1016/j.jviromet.2016.04.021
- Author:
- Reid Scott M.; Banks Jill; Ceeraz Vanessa; Seekings Amanda; Howard Wendy A.; Puranik Anita; Collins Susan; Manvell Ruth; Irvine Richard M.; Brown Ian H.
- Source:
- Avian diseases 2016 v.60 no.1s pp. 126-131
- ISSN:
- 0005-2086
- Subject:
- Anas platyrhynchos; Influenza A virus; air; anorexia; antibiotics; avian influenza; breeding; control methods; disease control; eggs; farms; flocks; genes; hemagglutination; hemagglutinins; hens; intravenous injection; males; morbidity; mortality; nucleotide sequences; nucleotides; occupational health and safety; pathogenicity; pathotypes; public health; rearing; reverse transcriptase polymerase chain reaction; risk; sequence analysis; sialidase; sinusitis; specific pathogen-free animals; turkey hens; viruses; East Asia; England
- Abstract:
- ... In April 2013, an H9N2 low pathogenicity avian influenza (LPAI) virus was isolated in a turkey breeder farm in Eastern England comprising 4966 birds. Point-of-lay turkey breeding birds had been moved from a rearing site and within 5 days had shown rapid onset of clinical signs of dullness, coughing, and anorexia. Three houses were involved, two contained a total of 4727 turkey hens, and the third ...
- DOI:
- 10.1637/11356-122315-Case.1
- https://doi.org/10.1637/11356-122315-Case.1
- Author:
- Kinga Biernacka; Paweł Karbowiak; Paweł Wróbel; Tomasz Charęza; Michał Czopowicz; Gyula Balka; Christa Goodell; Rolf Rauh; Tomasz Stadejek
- Source:
- Research in veterinary science 2016 v.109 pp. 74-80
- ISSN:
- 0034-5288
- Subject:
- Influenza A virus; Porcine reproductive and respiratory syndrome virus; antibodies; antibody detection; blood sampling; blood serum; enzyme-linked immunosorbent assay; farms; live vaccines; maternal immunity; nucleic acids; pathogens; quantitative polymerase chain reaction; sequence analysis; swine; weanlings
- Abstract:
- ... Recently oral fluid has become a novel sample type for pathogen nucleic acid and antibody detection, as it is easy to obtain with non-invasive procedures. The objective of the study was to analyze porcine reproductive and respiratory syndrome virus (PRRSV) and influenza A virus (IAV) circulation in growing pigs from three Polish production farms, using Real Time PCR and ELISA testing of oral fluid ...
- DOI:
- 10.1016/j.rvsc.2016.09.014
- https://doi.org/10.1016/j.rvsc.2016.09.014