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You searched for: Publication Year 2016 Remove constraint Publication Year: 2016 Subject biomarkers Remove constraint Subject: biomarkers
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1. 14. Effect of Dietary Supplementation of Garlic (Allium Sativum) and Turmeric (Curcuma Longa) on Growth Performance, Carcass Traits, Blood Profile and Oxidative Status in Growing Rabbits

Author:
Mahmoud Alagawany; Elwy Ali Ashour; Fayez Mohamed Reda
Source:
Annals of animal science 2016 v.16 no.2 pp. 489-505
ISSN:
2300-8733
Subject:
Allium sativum; Curcuma longa; additives; alanine transaminase; albumins; antioxidant activity; aspartate transaminase; biomarkers; blood serum; carcass characteristics; catalase; cholesterol; diet; garlic; glutathione; glutathione peroxidase; growth performance; growth promotion; immune response; immunoglobulin G; immunoglobulin M; lipid composition; lipid peroxidation; liver; protein content; rabbits; superoxide dismutase; triacylglycerols; turmeric
Abstract:
... This study was performed to investigate the effects of dietary supplementation with garlic and turmeric powder as growth promoter agents on performance, carcass traits, serum biochemistry, and antioxidant enzyme activities of growing rabbits. A total of 112 New Zealand White rabbits (NZW) at 5 weeks of age were randomly assigned to seven treatments with four replicates. The dietary treatments cons ...
DOI:
10.1515/aoas-2015-0079

2. 15‐F2t‐Isoprostane Concentrations and Oxidant Status in Lactating Dairy Cattle with Acute Coliform Mastitis

Author:
V. Mavangira; M.J. Mangual; J.C. Gandy; L.M. Sordillo
Source:
Journal of veterinary internal medicine 2016 v.30 no.1 pp. 339-347
ISSN:
0891-6640
Subject:
Holstein; animal tissues; biomarkers; case-control studies; coliform bacteria; correlation; dairy cows; enzyme-linked immunosorbent assay; humans; inflammation; lactation; liquid chromatography; mammary glands; mastitis; milk; oxidants; oxidative stress; tandem mass spectrometry; urine
Abstract:
... BACKGROUND: Severe mammary tissue damage during acute coliform mastitis in cattle is partially caused by oxidative stress. Although considered a gold standard biomarker in some human conditions, the utility of 15‐F₂ₜ‐Isoprostanes (15‐F₂ₜ‐Isop) in detecting oxidative stress in dairy cattle has not been validated. HYPOTHESIS: Concentrations of 15‐F₂ₜ‐Isop in plasma, urine, and milk correlate with ch ...
DOI:
10.1111/jvim.13793
PubMed:
26566597
PubMed Central:
PMC4913657
CHORUS:
10.1111/jvim.13793
Chorus Open Access:
10.1111/jvim.13793

3. 1H NMR-based metabolite profiling workflow to reduce inter-sample chemical shift variations in urine samples for improved biomarker discovery

Author:
Ryan B. Gil; Rainer Lehmann; Philippe Schmitt-Kopplin; Silke S. Heinzmann
Source:
Analytical and bioanalytical chemistry 2016 v.408 no.17 pp. 4683-4691
ISSN:
1618-2642
Subject:
biomarkers; citrates; clinical trials; data collection; fluorides; human diseases; humans; kidney diseases; metabolites; metabolomics; nuclear magnetic resonance spectroscopy; pH; phosphates; potassium; proteinuria; spectral analysis; statistical analysis; urine
Abstract:
... Metabolite profiling of urine has seen much advancement in recent years, and its analysis by nuclear magnetic resonance (NMR) spectroscopy has become well established. However, the highly variable nature of human urine still requires improved protocols despite some standardization. In particular, diseases such as kidney disease can have a profound effect on the composition of urine and generate a ...
DOI:
10.1007/s00216-016-9552-6

4. 2 CIRCULATING microRNA SIGNATURES ASSOCIATED WITH EARLY BOVINE PREGNANCY

Author:
J. Ioannidis; X. Donadeu
Source:
Reproduction, fertility, and development 2016 v.28 no.2 pp. 130
ISSN:
1031-3613
Subject:
Holstein; animal ovaries; biomarkers; calving; dairy cattle; dairy herds; diabetes; gene expression regulation; heifers; high-throughput nucleotide sequencing; humans; microRNA; milk production; polymerase chain reaction; pregnancy; pregnancy diagnosis; profits and margins; swine
Abstract:
... High-producing dairy cattle are characterised by low fertility, which extends calving intervals and reduces annual milk production. Early pregnancy diagnosis before Day 21 of gestation can shorten calving intervals, improve milk production, and increase overall profits from modern dairy herds. At present, accurate diagnosis is only possible after the third week of pregnancy. Circulating microRNA ( ...
DOI:
10.1071/RDv28n2Ab1

5. 3,4-seco-28-Nor-oleanane triterpenes from Camellia japonica protect from neurotoxicity in a rotenone model of Parkinson's disease

Author:
Jun Li Yang; Thi Kim Quy Ha; Basanta Dhodary; Ji Yeon Seo; Hyunju Kim; Junsoo Park; Won Keun Oh
Source:
Tetrahedron 2016 v.72 pp. 3240-3249
ISSN:
0040-4020
Subject:
Camellia japonica; Parkinson disease; autophagy; bioactive compounds; biomarkers; chemical reactions; chemical structure; ethanol; flowers; fractionation; humans; models; neurons; neuroprotective effect; neurotoxicity; nuclear magnetic resonance spectroscopy; reactive oxygen species; rotenone; triterpenoids
Abstract:
... A natural material extract library (Korea Bioactive Natural Material Bank) was screened with respect to their protective effects on neuronal cells, and a 70% ethanol extract from the flowers of Camellia japonica turned out to be a potential hit. Bioassay-guided fractionation of this active extract led to the isolation of six new 3,4-seco-28-nor-oleanane triterpenoids (1–6). The molecular structure ...
DOI:
10.1016/j.tet.2016.04.045

6. 56Fe ion irradiation induced apoptosis through Nrf2 pathway in mouse testis

Author:
Qiuyue Zhao; Aihong Mao; Jiawei Yan; Jing Si; Rong Zhou; Lu Gan; Yang Liu; Hong Zhang
Source:
Life sciences 2016 v.157 pp. 32-37
ISSN:
0024-3205
Subject:
Western blotting; apoptosis; biomarkers; dose response; flow cytometry; fluorescent antibody technique; gene expression regulation; genetic markers; ions; irradiation; mice; protein synthesis; space flight; spermatogenesis; testes
Abstract:
... The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as 56Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews during and after missions. Since the testis is a radiosensitive organ, which may be susc ...
DOI:
10.1016/j.lfs.2016.05.043

7. IL- 6, a central acute-phase mediator, as an early biomarker for exposure to zinc-based metal fumes

Author:
R. Baumann; S. Joraslafsky; A. Markert; I. Rack; S. Davatgarbenam; V. Kossack; B. Gerhards; T. Kraus; P. Brand; M. Gube
Source:
Toxicology 2016 v.373 pp. 63-73
ISSN:
0300-483X
Subject:
C-reactive protein; air; aluminum; amyloid; biomarkers; blood serum; breathing; cardiovascular diseases; copper; intercellular adhesion molecule-1; interferon-gamma; interleukin-6; lung function; males; risk factors; vascular cell adhesion molecules; welding; zinc
Abstract:
... Systemic C-reactive protein (CRP) increases 1day after short-term inhalation of welding fumes containing zinc and/or copper. The aim of the current study was to find further, possibly earlier systemic biomarkers after inhalation of different welding fumes containing zinc and traces of aluminum, with or without copper, as these metal combinations become more common in modern joining technology.The ...
DOI:
10.1016/j.tox.2016.11.001

8. 8‐Hydroxy‐2′‐deoxyguanosine as a biomarker of oxidative DNA damage induced by perfluorinated compounds in TK6 cells

Author:
Doha Yahia; Igarashi Haruka; Yae Kagashi; Shuji Tsuda
Source:
Environmental toxicology 2016 v.31 no.2 pp. 192-200
ISSN:
1520-4081
Subject:
DNA; DNA damage; biomarkers; carcinogens; computer software; dose response; gel electrophoresis; genotoxicity; high performance liquid chromatography; humans; perfluorocarbons; reactive oxygen species; spectroscopy
Abstract:
... 8‐Hydroxy‐2′‐deoxyguanosine (8‐OHdG) is the most common biomarker of oxidative DNA damage, it is formed by chemical carcinogens and can be measured in any species. Perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) are suspected genotoxic carcinogens through induction of reactive oxygen species that are responsible for oxidative DNA damage. This study was conducted to investigate the ...
DOI:
10.1002/tox.22034

9. AFBI assay – Aptamer Fluorescence Binding and Internalization assay for cultured adherent cells

Author:
William H. Thiel; Paloma H. Giangrande
Source:
Methods 2016 v.103 pp. 180-187
ISSN:
1046-2023
Subject:
DNA; RNA; biomarkers; flow cytometry; fluorescence; oligonucleotides; quantitative polymerase chain reaction; rapid methods; screening; systematic evolution of ligands by exponential enrichment
Abstract:
... The SELEX (Systematic Evolution of Ligands by Exponential Enrichment) process allows for the enrichment of DNA or RNA aptamers from a complex nucleic acid library that are specific for a target molecule. The SELEX process has been adapted from identifying aptamers in vitro using recombinant target protein to cell-based methodologies (Cell-SELEX), where the targets are expressed on the surface of c ...
DOI:
10.1016/j.ymeth.2016.03.005
PubMed:
26972784
PubMed Central:
PMC4921262

10. Abdominal fat radiodensity, quantity and cardiometabolic risk: The Multi-Ethnic Study of Atherosclerosis

Author:
Ravi V. Shah; M.A. Allison; J.A.C. Lima; S.A. Abbasi; A. Eisman; C. Lai; M. Jerosch-Herold; M. Budoff; V.L. Murthy
Source:
Nutrition, metabolism, and cardiovascular diseases 2016 v.26 no.2 pp. 114-122
ISSN:
0939-4753
Subject:
C-reactive protein; abdominal fat; adiponectin; atherosclerosis; biomarkers; computed tomography; inflammation; insulin; insulin resistance; leptin; metabolic syndrome; metabolism; nationalities and ethnic groups; regression analysis; risk factors; visceral fat
Abstract:
... Fat radiodensity, as measured by fat attenuation on computed tomography (CT), has emerged as a potential biomarker of “fat quality.” We sought to characterize the relationship between fat radiodensity and quantity in subcutaneous, visceral, and intermuscular fat depots, and its role in inflammation, insulin resistance, and metabolic syndrome (MetS).We studied 1511 individuals from the Multi-Ethnic ...
DOI:
10.1016/j.numecd.2015.12.002
PubMed:
26817938
PubMed Central:
PMC4775418

11. Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress

Author:
Ryusuke Akihara; Takujiro Homma; Jaeyong Lee; Ken-ichi Yamada; Satoshi Miyata; Junichi Fujii
Source:
Biochemical and biophysical research communications 2016 v.478 no.2 pp. 765-771
ISSN:
0006-291X
Subject:
aldehyde reductase; antioxidant activity; ascorbic acid; biomarkers; biosynthesis; carbon; carbon tetrachloride; endoplasmic reticulum stress; fatty liver; hepatotoxicity; homeostasis; liver; mice; models; oxidative stress; protective effect
Abstract:
... Aldehyde reductase (Akr1a) has been reported to be involved in the biosynthesis of ascorbic acid (AsA) in the mouse liver. Because Akr1a is expressed at high levels in the liver, we aimed to investigate the role of Akr1a in liver homeostasis by employing a carbon tetrachloride (CCl4)-induced hepatotoxicity model. Akr1a-deficient (Akr1a⁻/⁻) and wild-type (WT) mice were injected intraperitoneally wi ...
DOI:
10.1016/j.bbrc.2016.08.022

12. Accountability studies of air pollution and health effects: lessons learned and recommendations for future natural experiment opportunities

Author:
David Q. Rich
Source:
Environment international 2016 pp. -
ISSN:
0160-4120
Subject:
air; air pollution; air quality; biomarkers; community health; data collection; environmental policy; epidemiology; experimental design; morbidity; mortality; planning; pollutants; researchers; statistical analysis; temporal variation; China; Ireland
Abstract:
... To address limitations of observational epidemiology studies of air pollution and health effects, including residual confounding by temporal and spatial factors, several studies have taken advantage of ‘natural experiments’, where an environmental policy or air quality intervention has resulted in reductions in ambient air pollution concentrations. Researchers have examined whether the population ...
DOI:
10.1016/j.envint.2016.12.019
PubMed:
28089581
PubMed Central:
PMC5291758

13. Accurate Quantification of Selenoprotein P (SEPP1) in Plasma Using Isotopically Enriched Seleno-peptides and Species-Specific Isotope Dilution with HPLC Coupled to ICP-MS/MS

Author:
Deitrich Christian L.; Cuello-Nuñez Susana; Kmiotek Diana; Torma Frank Attila; del Castillo Busto Maria Estela; Fisicaro Paola; Goenaga-Infante Heidi
Source:
Analytical chemistry 2016 v.88 no.12 pp. 6357-6365
ISSN:
1520-6882
Subject:
biomarkers; certification; clinical trials; diabetes; high performance liquid chromatography; human nutrition; humans; isotope dilution technique; mass spectrometry; neoplasms; normal values; selenium; selenoproteins; uncertainty
Abstract:
... A novel strategy for the absolute quantification of selenium (Se) included in selenoprotein P (SEPP₁), an important biomarker for human nutrition and disease, including diabetes and cancer, is presented here for the first time. It is based on the use of species-specific double isotope dilution mass spectrometry (SSIDA) in combination with HPLC-ICP-MS/MS for the determination of protein bound Se do ...
DOI:
10.1021/acs.analchem.6b00715

14. Acid Dissociation of 3-Mercaptopropionic Acid Coated CdSe–CdS/Cd0.5Zn0.5S/ZnS Core–Multishell Quantum Dot and Strong Ionic Interaction with Ca2+ Ion

Author:
Shambetova Nestan; Chen Yun; Xu Hao; Li Li; Solandt Johan; Zhou Yuhua; Wang Jingbo; Su Haibin; Brismar Hjalmar; Fu Ying
Source:
The Journal of Physical Chemistry C 2016 v.120 no.6 pp. 3519-3529
ISSN:
1932-7455
Subject:
3-mercaptopropionic acid; anodes; biomarkers; calcium; chelating agents; dissociation; electrophoresis; ethylene glycol tetraacetic acid; fluorescence; image analysis; ions; optical properties; pH; physical chemistry; quantum dots
Abstract:
... By devising careful electrophoresis, it was shown that at pH below 7.0, the electrophoretic mobility of 3-mercaptopropionic acid (3MPA) coated CdSe–ZnS core–shell quantum dots (denoted as QD-3MPA) was very small. At pH above 7.0, QD-3MPA migrated toward the anode, implying acid dissociation, and the degree of which was proportional to the pH value. QD-3MPA’s electrophoretic mobility was impaired a ...
DOI:
10.1021/acs.jpcc.5b11023

15. Acoustic wave biosensor for the detection of the breast and prostate cancer metastasis biomarker protein PTHrP

Author:
Victor Crivianu-Gaita; Mohamed Aamer; Roy T. Posaratnanathan; Alexander Romaschin; Michael Thompson
Source:
Biosensors & bioelectronics 2016 v.78 pp. 92-99
ISSN:
0956-5663
Subject:
X-ray photoelectron spectroscopy; acoustics; antibodies; biomarkers; biosensors; bovine serum albumin; detection limit; ethanolamine; fouling; metastasis; prostatic neoplasms
Abstract:
... There are currently no biosensors that are able to reliably detect the process of cancer metastasis. We describe the first label-free real-time ultra-high frequency acoustic wave biosensor prototype capable of detecting the breast and prostate cancer metastasis biomarker, parathyroid hormone-related peptide (PTHrP). Two different linkers – 11-trichlorosilyl-undecanoic acid pentafluorophenyl ester ...
DOI:
10.1016/j.bios.2015.11.031

16. Activation of CO2-reducing methanogens in oil reservoir after addition of nutrient

Author:
Guang-Chao Yang; Lei Zhou; Serge Maurice Mbadinga; Jing You; Hua-Zhen Yang; Jin-Feng Liu; Shi-Zhong Yang; Ji-Dong Gu; Bo-Zhong Mu
Source:
Journal of bioscience and bioengineering 2016 v.122 no.6 pp. 740-747
ISSN:
1389-1723
Subject:
Firmicutes; Methanobacteriales; Methanomicrobiales; Methanosaetaceae; biomarkers; community structure; energy recovery; genes; methane production; methanogens; microbial communities; multidimensional scaling; oil fields; oils; petroleum; quantitative analysis; quantitative polymerase chain reaction
Abstract:
... Nutrient addition as part of microbial enhanced oil recovery (MEOR) operations have important implications for more energy recovery from oil reservoirs, but very little is known about the in situ response of microorganisms after intervention. An analysis of two genes as biomarkers, mcrA encoding the key enzyme in methanogenesis and fthfs encoding the key enzyme in acetogenesis, was conducted durin ...
DOI:
10.1016/j.jbiosc.2016.06.011

17. Active biomonitoring of mussels Mytilus galloprovincialis with integrated use of micronucleus assay and physiological indices to assess harbor pollution

Author:
Hamida Gherras Touahri; Zitouni Boutiba; Wacila Benguedda; Sergey Shaposhnikov
Source:
Marine pollution bulletin 2016 v.110 no.1 pp. 52-64
ISSN:
0025-326X
Subject:
Mytilus galloprovincialis; biomarkers; environmental monitoring; gills; hemolymph; mussels; physiological state; pollution
Abstract:
... The mussels Mytilus galloprovincialis collected from a noncontaminated site (Chaib Rasso) were transplanted during one, three and six months at Ghazaouet harbor (GH), areas with a strong gradient of pollution. The micronucleus test (MN) was selected to monitor the impact of contamination, along with physiological indexes (condition index CI and organo-somatic indexes RI and GSI). The results show ...
DOI:
10.1016/j.marpolbul.2016.06.029

18. Acute Garcinia mangostana (mangosteen) supplementation does not alleviate physical fatigue during exercise: a randomized, double-blind, placebo-controlled, crossover trial

Author:
Chih-Wei Chang; Tzu-Zung Huang; Wen-Hsin Chang; Yi-Chun Tseng; Yu-Tse Wu; Mei-Chich Hsu
Source:
Journal of the International Society of Sports Nutrition 2016 v.13 no.1 pp. 20
ISSN:
1550-2783
Subject:
Garcinia mangostana; adults; alanine transaminase; ammonia; aspartate transaminase; biomarkers; blood; cortisol; creatine kinase; cross-over studies; emotions; exercise; flavor; fruits; glucose; heart rate; juices; lactic acid; mangosteens; muscles; oral administration; placebos; sports nutrition
Abstract:
... BACKGROUND: The purple mangosteen (Garcinia mangostana), known as the "queen of fruit," is widely consumed and unique not only because of its outstanding appearance and flavor but also its remarkable and diverse pharmacological effects. The aim of the present study is to evaluate the effect of acute mangosteen supplementation on physical fatigue during exercise. METHODS: A randomized, double-blind ...
DOI:
10.1186/s12970-016-0132-0
PubMed:
27152103
PubMed Central:
PMC4857437

19. Acute and chronic effects of erythromycin exposure on oxidative stress and genotoxicity parameters of Oncorhynchus mykiss

Author:
S. Rodrigues; S.C. Antunes; A.T. Correia; B. Nunes
Source:
Science of the total environment 2016 v.545-546 pp. 591-600
ISSN:
0048-9697
Subject:
DNA; DNA damage; Oncorhynchus mykiss; biomarkers; blood cells; catalase; chromosome breakage; chronic exposure; data collection; erythromycin; genetic techniques and protocols; genotoxicity; gills; glutathione peroxidase; glutathione-disulfide reductase; humans; lipid peroxidation; liver; long term effects; nontarget organisms; oxidation; oxidative stress; thiobarbituric acid-reactive substances; veterinary medicine
Abstract:
... Erythromycin (ERY) is a macrolide antibiotic used in human and veterinary medicine, and has been detected in various aquatic compartments. Recent studies have indicated that this compound can exert biological activity on non-target organisms environmentally exposed. The present study aimed to assess the toxic effects of ERY in Oncorhynchus mykiss after acute and chronic exposures. The here adopted ...
DOI:
10.1016/j.scitotenv.2015.10.138

20. Acute consumption of organic and conventional tropical grape juices (Vitis labrusca L.) increases antioxidants in plasma and erythrocytes, but not glucose and uric acid levels, in healthy individuals

Author:
Isabela Maia Toaldo; Fernanda Alves Cruz; Edson Luiz da Silva; Marilde T. Bordignon-Luiz
Source:
Nutrition research 2016 v.36 pp. 808-817
ISSN:
0271-5317
Subject:
Vitis labrusca; acute effects; antioxidant activity; antioxidants; biomarkers; blood sampling; blood serum; catalase; cultivars; erythrocytes; glucose; glutathione; glutathione peroxidase; grape juice; grapes; homeostasis; humans; ingestion; organic foods; oxidative stress; polyphenols; superoxide dismutase; tropics; uric acid
Abstract:
... Bioactive polyphenols in grapes are influenced by grape variety and cultivation conditions. The Vitis labrusca L. varieties are cultivated in tropical regions and used for grape juice production. We hypothesized that polyphenols from tropical grape juices would beneficially affect redox homeostasis in humans. Therefore, the effects of acute consumption of organic and conventional grape juices from ...
DOI:
10.1016/j.nutres.2016.04.010