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- Yin-bo Fan; Min Huang; Yu Cao; Ping Gong; Wen-bing Liu; Shu-yu Jin; Jia-chen Wen; Yong-kui Jing; Dan Liu; Lin-xiang Zhao
- RSC advances 2016 v.6 no.29 pp. 24091-24096
- apoptosis; cell lines; dibenzofuran; enzyme inhibition; enzymes; humans; lichens; mechanism of action; mice; myeloid leukemia; neoplasm cells; pro-apoptotic proteins; secondary metabolites; therapeutics; usnic acid
- ... Usnic acid (UA) is a secondary metabolite of lichens with a unique dibenzofuran scaffold. The growth inhibitory and apoptotic effects of UA as well as the potential mechanisms of action were determined in human acute myeloid leukemia HL-60 cells and chronic myeloid leukemia K562 cells. UA inhibits growth and induces apoptosis in both cell lines with HL-60 cells more responsive. The apoptotic effec ...