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1. Usnic acid is a novel Pim-1 inhibitor with the abilities of inhibiting growth and inducing apoptosis in human myeloid leukemia cells

Author:
Yin-bo Fan; Min Huang; Yu Cao; Ping Gong; Wen-bing Liu; Shu-yu Jin; Jia-chen Wen; Yong-kui Jing; Dan Liu; Lin-xiang Zhao
Source:
RSC advances 2016 v.6 no.29 pp. 24091-24096
ISSN:
2046-2069
Subject:
apoptosis; cell lines; dibenzofuran; enzyme inhibition; enzymes; humans; lichens; mechanism of action; mice; myeloid leukemia; neoplasm cells; pro-apoptotic proteins; secondary metabolites; therapeutics; usnic acid
Abstract:
... Usnic acid (UA) is a secondary metabolite of lichens with a unique dibenzofuran scaffold. The growth inhibitory and apoptotic effects of UA as well as the potential mechanisms of action were determined in human acute myeloid leukemia HL-60 cells and chronic myeloid leukemia K562 cells. UA inhibits growth and induces apoptosis in both cell lines with HL-60 cells more responsive. The apoptotic effec ...
DOI:
10.1039/c6ra01159d