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1. Neovascularization Induced by the Hyaluronic Acid-Based Spongy-Like Hydrogels Degradation Products

Author:
Silva Lucília P. da; Pirraco Rogério P.; Santos Tírcia C.; Novoa-Carballal Ramon; Cerqueira Mariana T.; Reis Rui L.; Correlo Vitor M.; Marques Alexandra P.
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.49 pp. 33464-33474
ISSN:
1944-8252
Subject:
angiogenesis; biodegradation; disaccharides; endothelial cells; gellan gum; hindlimbs; humans; hyaluronic acid; hydrogels; medicine; receptors; tissue engineering; tissue repair; umbilical cord
Abstract:
... Neovascularization has been a major challenge in many tissue regeneration strategies. Hyaluronic acid (HA) of 3–25 disaccharides is known to be angiogenic due to its interaction with endothelial cell receptors. This effect has been explored with HA-based structures but a transitory response is observed due to HA burst biodegradation. Herein we developed gellan gum (GG)-HA spongy-like hydrogels fro ...
DOI:
10.1021/acsami.6b11684