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You searched for: Publication Year 2016 Remove constraint Publication Year: 2016 Subject term Shiga-like toxins Remove constraint Subject term: Shiga-like toxins
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1. Efficient and regioselective synthesis of globotriose by a novel α-galactosidase from Bacteroides fragilis

Author:
Wei Gong; Li Xu; Guofeng Gu; Lili Lu; Min Xiao
Source:
Applied microbiology and biotechnology 2016 v.100 no.15 pp. 6693-6702
ISSN:
0175-7598
Subject:
Bacteroides fragilis; DNA; Escherichia coli; Shiga-like toxins; alpha-galactosidase; amino acids; bacterial infections; epitopes; genes; glycosides; lactose; melibiose; molecular weight; neoplasms; pH; polysaccharides; temperature; therapeutics
Abstract:
... Globotriose (Galα1–4Galβ1–4Glc) is an important cell surface epitope that acts as the receptor for Shiga-like toxins, and it is also the core structure of Globo H and SSEA4 that are tumor-associated glycans. Hence, the enzymatic synthesis of globotriose would be necessary for the development of carbohydrate-based therapeutics for bacterial infections and cancers. Here, a novel GH27 α-galactosidase ...
DOI:
10.1007/s00253-016-7464-1

2. Enterohemorrhagic Escherichia coli (EHEC) in water from karst springs: detection with real-time PCR and isolation of strains

Author:
Andreas Baumgartner; Isabel Niederhauser; David Diston; Dominik Moor
Source:
Journal für Verbraucherschutz und Lebensmittelsicherheit 2016 v.11 no.4 pp. 353-357
ISSN:
1661-5751
Subject:
Shiga-like toxins; enterohemorrhagic Escherichia coli; food safety; foods; genes; intimin; karsts; quantitative polymerase chain reaction; springs (water); virulence; virulent strains; Switzerland
Abstract:
... Within 2 months, two water sources in a karst area in Switzerland were sampled 9 times each, and analyzed by real-time PCR for 6 EHEC O-types, Shiga-like-toxin (stx1 and stx2) and intimin (eae) genes. With the exception of O111, 5 O-types were recorded regularly and at high frequencies (O26: 33.3 %; O157: 33.3 %; O104: 66.6 %; O103: 72.2 %; O145: 94.4 %). Genes for Shiga-like-toxins and intimin we ...
DOI:
10.1007/s00003-016-1053-1