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evolution
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antibiotics
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- Author:
- Elicia D. Grace; Saumya Gopalkrishnan; Mary E. Girard; Matthew D. Blankschien; Wilma Ross; Richard L. Gourse; Christophe Herman
- Source:
- Journal of bacteriology 2015 v.197 no.5 pp. 924-931
- ISSN:
- 0021-9193
- Subject:
- DNA-directed RNA polymerase; Escherichia coli; antibiotic resistance; antibiotics; bacteria; biosynthesis; evolution; fimbriae; horizontal gene transfer; pathogens; plasmids; protein folding; proteinases; signal transduction; stress response; virulence
- Abstract:
- ... Horizontal gene transfer by conjugation plays a major role in bacterial evolution, allowing the acquisition of new traits, such as virulence and resistance to antibacterial agents. With the increased antibiotic resistance in bacterial pathogens, a better understanding of how bacteria modulate conjugation under changing environments and the genetic factors involved is needed. Despite the evolutiona ...
- DOI:
- 10.1128/JB.02279-14
- PubMed:
- 25535270
- PubMed Central:
- PMC4325106
- https://doi.org/10.1128/JB.02279-14
2. Antimicrobial interactions: mechanisms and implications for drug discovery and resistance evolution
- Author:
- Tobias Bollenbach
- Source:
- Current opinion in microbiology 2015 v.27 pp. 1-9
- ISSN:
- 1369-5274
- Subject:
- antibiotics; cell physiology; combination drug therapy; drug interactions; drugs; evolution; prediction
- Abstract:
- ... Combining antibiotics is a promising strategy for increasing treatment efficacy and for controlling resistance evolution. When drugs are combined, their effects on cells may be amplified or weakened, that is the drugs may show synergistic or antagonistic interactions. Recent work revealed the underlying mechanisms of such drug interactions by elucidating the drugs’ joint effects on cell physiology ...
- DOI:
- 10.1016/j.mib.2015.05.008
- https://doi.org/10.1016/j.mib.2015.05.008
- Author:
- Angelina Lo Giudice; Renato Fani
- Source:
- Hydrobiologia 2015 v.761 no.1 pp. 417-441
- ISSN:
- 0018-8158
- Subject:
- sediments; bioactive properties; antibiotics; evolution; heavy metals; humans; biotechnology; biochemical pathways; environmental factors; polychlorinated biphenyls; seawater; secondary metabolites; bacterial communities; anthropogenic activities; coasts; temperature; bacteria; Antarctica; Antarctic region
- Abstract:
- ... This review covers available information concerning the bacterial communities inhabiting coastal areas of Terra Nova Bay (Antarctica). Research was mainly focused on seawater, sediment, and benthic filter feeders. Coping with adverse environmental conditions, Antarctic bacteria have evolved peculiar strategies to survive in this harsh environment. In addition to cellular modifications, antagonisti ...
- DOI:
- 10.1007/s10750-015-2497-5
- https://doi.org/10.1007/s10750-015-2497-5
- Author:
- Csaba Pál; Balázs Papp; Viktória Lázár
- Source:
- Trends in microbiology 2015 v.23 no.7 pp. 401-407
- ISSN:
- 0966-842X
- Subject:
- antibiotic resistance; antibiotics; bacteria; drugs; evolution; multiple drug resistance; mutation; resistance mechanisms; sequence analysis
- Abstract:
- ... Understanding how evolution of microbial resistance towards a given antibiotic influences susceptibility to other drugs is a challenge of profound importance. By combining laboratory evolution, genome sequencing, and functional analyses, recent works have charted the map of evolutionary trade-offs between antibiotics and have explored the underlying molecular mechanisms. Strikingly, mutations that ...
- DOI:
- 10.1016/j.tim.2015.02.009
- PubMed:
- 25818802
- PubMed Central:
- PMC5958998
- https://doi.org/10.1016/j.tim.2015.02.009
- Author:
- Alexsandro Santana Vieira; Maria Izabel Camargo-Mathias; Flavio Roces
- Source:
- Arthropod structure & development 2015 v.44 no.5 pp. 444-454
- ISSN:
- 1467-8039
- Subject:
- Atta sexdens rubropilosa; antibiotics; antiseptics; evolution; fungus gardens; leaf-cutting ants; microorganisms; nesting; organic matter; organic soils; pathogens; queen insects; risk; soil depth; soil horizons
- Abstract:
- ... Queens of leaf-cutting ants found their nests singly, each consisting of a vertical tunnel and a final horizontal chamber. Because of the claustral mode of nest founding, the queen and/or her initial fungus garden are exposed to threats imposed by several soil pathogens, and the antibiotic secretions produced by their metapleural glands are considered a main adaptation to deal with them. Nests of ...
- DOI:
- 10.1016/j.asd.2015.06.005
- https://doi.org/10.1016/j.asd.2015.06.005
- Author:
- Renata de Oliveira Dias; Octavio Luiz Franco
- Source:
- Peptides 2015 v.72 pp. 64-72
- ISSN:
- 0196-9781
- Subject:
- amino acids; antibacterial properties; antibiotics; antimicrobial peptides; bacteria; disulfide bonds; evolution; fungi; invertebrates; mechanism of action
- Abstract:
- ... Antimicrobial peptides (AMPs) seem to be promising alternatives to common antibiotics, which are facing increasing bacterial resistance. Among them are the cysteine-stabilized αβ defensins. These peptides are small, with a length ranging from 34 to 54 amino acid residues, cysteine-rich and extremely stable, normally composed of an α-helix and three β-strands stabilized by three or four disulfide b ...
- DOI:
- 10.1016/j.peptides.2015.04.017
- https://doi.org/10.1016/j.peptides.2015.04.017
- Author:
- Han Xiao; Fariborz Nasertorabi; Sei-hyun Choi; Gye Won Han; Sean A. Reed; Raymond C. Stevens; Peter G. Schultz
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.22 pp. 6961-6966
- ISSN:
- 0027-8424
- Subject:
- amino acids; antibiotics; beta-lactamase; catalytic activity; evolution; genetic code; mutants; mutation
- Abstract:
- ... With few exceptions, all living organisms encode the same 20 canonical amino acids; however, it remains an open question whether organisms with additional amino acids beyond the common 20 might have an evolutionary advantage. Here, we begin to test that notion by making a large library of mutant enzymes in which 10 structurally distinct noncanonical amino acids were substituted at single sites ran ...
- DOI:
- 10.1073/pnas.1507741112
- PubMed:
- 26038548
- PubMed Central:
- PMC4460475
- https://doi.org/10.1073/pnas.1507741112
- Author:
- Jacob Amy; Priscilla Johanesen; Dena Lyras
- Source:
- Plasmid 2015 v.80 pp. 97-110
- ISSN:
- 0147-619X
- Subject:
- Clostridium difficile; antibiotic resistance; antibiotics; bacteria; cross infection; digestive system diseases; evolution; interspersed repetitive sequences; pathogens; patients; phenotype; plasmids; sequence analysis; therapeutics
- Abstract:
- ... Clostridium difficile is a major nosocomial pathogen, causing gastrointestinal disease in patients undergoing antibiotic therapy. This bacterium contains many extrachromosomal and integrated genetic elements, with recent genomic work giving new insights into their variability and distribution. This review summarises research conducted in this area over the last 30 years and includes a discussion o ...
- DOI:
- 10.1016/j.plasmid.2015.04.006
- https://doi.org/10.1016/j.plasmid.2015.04.006
- Author:
- Kristine Stepanyan; Tom Wenseleers; Edgar A. Duéñez‐Guzmán; Frédéric Muratori; Bram Van den Bergh; Natalie Verstraeten; Luc De Meester; Kevin J. Verstrepen; Maarten Fauvart; Jan Michiels
- Source:
- Molecular ecology 2015 v.24 no.7 pp. 1572-1583
- ISSN:
- 0962-1083
- Subject:
- Pseudomonas aeruginosa; antibiotics; evolution; humans; infectious diseases; models; pathogens
- Abstract:
- ... Microbial populations often contain a fraction of slow‐growing persister cells that withstand antibiotics and other stress factors. Current theoretical models predict that persistence levels should reflect a stable state in which the survival advantage of persisters under adverse conditions is balanced with the direct growth cost impaired under favourable growth conditions, caused by the nonreplic ...
- DOI:
- 10.1111/mec.13127
- https://doi.org/10.1111/mec.13127
- Author:
- Susu He; Alison Burgess Hickman; Alessandro M. Varani; Patricia Siguier; Michael Chandler; John P. Dekker; Fred Dyda
- Source:
- mBio 2015 v.6 no.3 pp. e00762-15
- ISSN:
- 2150-7511
- Subject:
- Enterobacteriaceae; National Institutes of Health; antibiotic resistance; antibiotics; bacteria; beta-lactamase; evolution; genes; monitoring; multiple drug resistance; phenotype; plasmids; public health; replicon; transposition (genetics); transposons
- Abstract:
- ... Carbapenemase-producing Enterobacteriaceae (CPE), which are resistant to most or all known antibiotics, constitute a global threat to public health. Transposable elements are often associated with antibiotic resistance determinants, suggesting a role in the emergence of resistance. One insertion sequence, IS 26 , is frequently associated with resistance determinants, but its role remains unclear. ...
- DOI:
- 10.1128/mBio.00762-15
- PubMed:
- 26060276
- PubMed Central:
- PMC4471558
- https://doi.org/10.1128/mBio.00762-15
- Author:
- Chrispin Chaguza; Jennifer E. Cornick; Dean B. Everett
- Source:
- Computational and Structural Biotechnology Journal 2015 v.13 pp. 241-247
- ISSN:
- 2001-0370
- Subject:
- DNA; Streptococcus pneumoniae; adaptive immunity; antibiotics; bacteria; evolution; genetic recombination; genetic variation; genome; mutation; population genetics; therapeutics; vaccines
- Abstract:
- ... Streptococcus pneumoniae (the pneumococcus) is a highly recombinogenic bacterium responsible for a high burden of human disease globally. Genetic recombination, a process in which exogenous DNA is acquired and incorporated into its genome, is a key evolutionary mechanism employed by the pneumococcus to rapidly adapt to selective pressures. The rate at which the pneumococcus acquires genetic variat ...
- DOI:
- 10.1016/j.csbj.2015.03.007
- PubMed:
- 25904996
- PubMed Central:
- PMC4404416
- https://doi.org/10.1016/j.csbj.2015.03.007
- Author:
- Cheryl P. Andam; William P. Hanage
- Source:
- Infection, genetics, and evolution 2015 v.33 pp. 334-342
- ISSN:
- 1567-1348
- Subject:
- Streptococcus pneumoniae; antibiotic resistance; antibiotics; disease control; evolution; genes; genomics; horizontal gene transfer; hosts; humans; pathogenicity; pathogens; phenotypic variation; population dynamics; respiratory system; serotypes; vaccines
- Abstract:
- ... The genus Streptococcus contains 104 recognized species, many of which are associated with human or animal hosts. A globally prevalent human pathogen in this group is Streptococcus pneumoniae (the pneumococcus). While being a common resident of the upper respiratory tract, it is also a major cause of otitis media, pneumonia, bacteremia and meningitis, accounting for a high burden of morbidity and ...
- DOI:
- 10.1016/j.meegid.2014.11.007
- PubMed:
- 25461843
- PubMed Central:
- PMC4430445
- https://doi.org/10.1016/j.meegid.2014.11.007
- Author:
- Sandra Pucciarelli; Raghul Rajan Devaraj; Alessio Mancini; Patrizia Ballarini; Michele Castelli; Martina Schrallhammer; Giulio Petroni; Cristina Miceli
- Source:
- Microbial ecology 2015 v.70 no.2 pp. 484-497
- ISSN:
- 0095-3628
- Subject:
- Francisella; antibiotics; antifreeze proteins; bacteria; cell division; cold; energy; enzymes; evolution; genes; metabolism; nucleotide sequences; Antarctic region; Antarctica
- Abstract:
- ... We report the characterization of the bacterial consortium associated to Euplotes focardii, a strictly psychrophilic marine ciliate that was maintained in laboratory cultures at 4 °C after its first isolation from Terra Nova Bay, in Antarctica. By Illumina genome analyser, we obtained 11,179 contigs of potential prokaryotic origin and classified them according to the NCBI’s prokaryotic attributes ...
- DOI:
- 10.1007/s00248-015-0568-9
- PubMed:
- 25704316
- PubMed Central:
- PMC4494151
- https://doi.org/10.1007/s00248-015-0568-9
- Author:
- Shingo Suzuki; Takaaki Horinouchi; Chikara Furusawa
- Source:
- Journal of bioscience and bioengineering 2015 v.120 no.4 pp. 467-469
- ISSN:
- 1389-1723
- Subject:
- antibiotic resistance; antibiotics; drugs; evolution
- Abstract:
- ... We analyzed the effect of combinatorial use of antibiotics with a trade-off relationship of resistance, i.e., resistance acquisition to one drug causes susceptibility to the other drug, and vice versa, on the evolution of antibiotic resistance. We demonstrated that this combinatorial use of antibiotics significantly suppressed the acquisition of resistance. ...
- DOI:
- 10.1016/j.jbiosc.2015.02.003
- https://doi.org/10.1016/j.jbiosc.2015.02.003
- Author:
- Culyba Matthew J.; Mo Charlie Y.; Kohli Rahul M.
- Source:
- Biochemistry 2015 v.54 no.23 pp. 3573-3582
- ISSN:
- 1520-4995
- Subject:
- antibiotic resistance; antibiotics; bacteria; biochemistry; drugs; evolution; horizontal gene transfer; pathogens; viability
- Abstract:
- ... Bacteria possess a remarkable ability to rapidly adapt and evolve in response to antibiotics. Acquired antibiotic resistance can arise by multiple mechanisms but commonly involves altering the target site of the drug, enzymatically inactivating the drug, or preventing the drug from accessing its target. These mechanisms involve new genetic changes in the pathogen leading to heritable resistance. T ...
- DOI:
- 10.1021/acs.biochem.5b00109
- PubMed:
- 26016604
- PubMed Central:
- PMC4471857
- https://doi.org/10.1021/acs.biochem.5b00109
- Author:
- Cameron J. Reid; Piklu Roy Chowdhury; Steven P. Djordjevic
- Source:
- Plasmid 2015 v.80 pp. 127-137
- ISSN:
- 0147-619X
- Subject:
- Escherichia coli; Salmonella enterica; antibiotic resistance; antibiotics; evolution; genes; multiple drug resistance; pathogens; plasmids; serotypes; transposons; virulence
- Abstract:
- ... Transposons flanked by direct copies of IS26 are important contributors to the evolution of multiple antibiotic resistance. Tn6029 and Tn6026 are examples of composite transposons that have become widely disseminated on small and large plasmids with different incompatibility markers in pathogenic and commensal Escherichia coli and various serovars of Salmonella enterica. Some of the plasmids that ...
- DOI:
- 10.1016/j.plasmid.2015.04.005
- https://doi.org/10.1016/j.plasmid.2015.04.005
- Author:
- Edward J. O’Brien; Jonathan M. Monk; Bernhard O. Palsson
- Source:
- Cell 2015 v.161 pp. 971-987
- ISSN:
- 0092-8674
- Subject:
- antibiotics; evolution; genes; metabolic engineering; models
- Abstract:
- ... Constraint-based reconstruction and analysis (COBRA) methods at the genome scale have been under development since the first whole-genome sequences appeared in the mid-1990s. A few years ago, this approach began to demonstrate the ability to predict a range of cellular functions, including cellular growth capabilities on various substrates and the effect of gene knockouts at the genome scale. Thus ...
- DOI:
- 10.1016/j.cell.2015.05.019
- PubMed:
- 26000478
- PubMed Central:
- PMC4451052
- https://doi.org/10.1016/j.cell.2015.05.019
- Author:
- Rita A. Rapa; Atiqul Islam; Leigh G. Monahan; Ankur Mutreja; Nicholas Thomson; Ian G. Charles; Harold W. Stokes; Maurizio Labbate
- Source:
- Environmental microbiology 2015 v.17 no.4 pp. 1090-1102
- ISSN:
- 1462-2912
- Subject:
- DNA; DNA damage; DNA repair; Escherichia coli; Vibrio cholerae; adhesins; antibiotics; bacteriophages; cholera; cholera toxin; evolution; genes; genomic islands; horizontal gene transfer; pathogens; toxigenic strains; virulence
- Abstract:
- ... Lateral gene transfer (LGT) has been crucial in the evolution of the cholera pathogen, Vibrio cholerae. The two major virulence factors are present on two different mobile genetic elements, a bacteriophage containing the cholera toxin genes and a genomic island (GI) containing the intestinal adhesin genes. Non‐toxigenic V. cholerae in the aquatic environment are a major source of novel DNA that al ...
- DOI:
- 10.1111/1462-2920.12512
- PubMed:
- 24889424
- PubMed Central:
- PMC4405046
- https://doi.org/10.1111/1462-2920.12512