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- Author:
- Maria Filippa Addis; Salvatore Pisanu; Elena Preziosa; Giovanni Bernardini; Daniela Pagnozzi; Tonina Roggio; Sergio Uzzau; Marco Saroglia; Genciana Terova
- Source:
- Journal of proteomics 2012 v.75 no.12 pp. 3654-3664
- ISSN:
- 1874-3919
- Subject:
- Dicentrarchus labrax; air; asphyxia; binding proteins; death; fish; fructose-bisphosphate aldolase; gel electrophoresis; glyceraldehyde-3-phosphate dehydrogenase; ice; muscle protein; muscle tissues; myosin heavy chains; nucleoside-diphosphate kinase; preserves; principal component analysis; slaughter; spinal cord
- Abstract:
- ... Two-dimensional difference gel electrophoresis (2D DIGE) was applied to investigate the impact of slaughtering on the postmortem integrity of muscle tissue proteins in European sea bass (Dicentrarchus labrax). Three different slaughtering techniques were evaluated: asphyxia in air (AA), asphyxia in ice (AI), and spinal cord severance (SCS). Principal components analysis (PCA) revealed a significan ...
- DOI:
- 10.1016/j.jprot.2012.04.021
- PubMed:
- 22561645
- https://doi.org/10.1016/j.jprot.2012.04.021
2. 3α-Hydroxymasticadienonic Acid As an Antiproliferative Agent That Impairs Mitochondrial Functions
- Author:
- Dalla Via Lisa; Braga Alessandra; García-Argáez Aída N.; Martínez-Vázquez Mariano; Toninello Antonio
- Source:
- Journal of natural products 2012 v.75 no.4 pp. 557-562
- ISSN:
- 1520-6025
- Subject:
- adenosine triphosphate; apoptosis; calcium; cations; cell viability; cytotoxicity; death; dose response; liver; membrane permeability; mitochondria; oxidative stress; rats
- Abstract:
- ... Previous investigations on the biological effects of 3α-hydroxymasticadienonic acid (1) have demonstrated both anti-inflammatory and cytotoxic activities. However, neither the molecular mechanism of cytotoxic action nor the possible intracellular target(s) have been reported so far for this compound. The crucial role played by mitochondria on both cell survival and death, due to production of ATP ...
- DOI:
- 10.1021/np200607b
- https://doi.org/10.1021/np200607b
- Author:
- Chia-Hua Liang; Guey-Horng Wang; Tzung-Han Chou; Shih-Hao Wang; Rong-Jyh Lin; Leong-Perng Chan; Edmund Cheung So; Jyh-Horng Sheu
- Source:
- Biochimica et biophysica acta 2012 v.1820 no.7 pp. 1149-1157
- ISSN:
- 0304-4165
- Subject:
- adverse effects; antineoplastic agents; apoptosis; caspase-8; caspase-9; cell cycle checkpoints; cell growth; cyclins; cytochrome c; death; humans; necrosis; neoplasm cells; patients; public health; receptors; signal transduction; skin neoplasms; tumor necrosis factor-alpha
- Abstract:
- ... BACKGROUND: Skin cancers are reportedly increasing worldwide. Developing novel anti-skin cancer drugs with minimal side effects is necessary to address this public health issue. Sinuleptolide has been demonstrated to possess anti-cancer cell activities; however, the mechanisms underlying the anti-skin cancer effects of 5-epi-sinuleptolide and sinuleptolide remain poorly understood. METHODS: Apopto ...
- DOI:
- 10.1016/j.bbagen.2012.02.003
- https://doi.org/10.1016/j.bbagen.2012.02.003
- Author:
- Cristina Penaranda; Wilson Kuswanto; Jerry Hofmann; Rupert Kenefeck; Parth Narendran; Lucy S. K. Walker; Jeffrey A. Bluestone; Abul K. Abbas; Hans Dooms
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.31 pp. 12668-12673
- ISSN:
- 0027-8424
- Subject:
- T-lymphocytes; animal disease models; autoimmune diseases; autoimmunity; death; diabetes mellitus; interferon-gamma; interleukin-7; mice; monoclonal antibodies; pathogenesis; therapeutics
- Abstract:
- ... To protect the organism against autoimmunity, self-reactive effector/memory T cells (T E/M) are controlled by cell-intrinsic and -extrinsic regulatory mechanisms. However, how some T E/M cells escape regulation and cause autoimmune disease is currently not understood. Here we show that blocking IL-7 receptor-α (IL-7Rα) with monoclonal antibodies in nonobese diabetic (NOD) mice prevented autoimmune ...
- DOI:
- 10.1073/pnas.1203692109
- PubMed:
- 22733744
- PubMed Central:
- PMC3411948
- https://doi.org/10.1073/pnas.1203692109
- Author:
- Lucy D. Rutherford; Steven P. Gieseg
- Source:
- Lipids 2012 v.47 no.3 pp. 239-247
- ISSN:
- 0024-4201
- Subject:
- cell culture; cell death; cell viability; culture media; cytotoxicity; death; low density lipoprotein; macrophages
- Abstract:
- ... The growth of the necrotic core region within advanced atherosclerotic plaque is thought to be driven by oxidised low density lipoprotein (oxLDL)-induced death of macrophage cells. OxLDL and atherosclerotic plaque are rich in oxysterols, especially 7-ketocholesterol (7KC). As 7KC triggers cell death at physiological concentrations when added directly to the cell culture media, 7KC and other oxyste ...
- DOI:
- 10.1007/s11745-011-3634-1
- https://doi.org/10.1007/s11745-011-3634-1
- Author:
- Michael J. Cutler; Bradley N. Plummer; Xiaoping Wan; Qi-An Sun; Douglas Hess; Haiyan Liu; Isabelle Deschenes; David S. Rosenbaum; Jonathan S. Stamler; Kenneth R. Laurita
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.44 pp. 18186-18191
- ISSN:
- 0027-8424
- Subject:
- allopurinol; arrhythmia; calcium; death; heart; myocytes; neuronal nitric oxide synthase; nitric oxide; oxidation; oxidative stress; phenotype; phosphorylation; physiological state; proteins; reactive oxygen species; sarcoplasmic reticulum; xanthine
- Abstract:
- ... Nitric oxide (NO) derived from the activity of neuronal nitric oxide synthase (NOS1) is involved in S-nitrosylation of key sarcoplasmic reticulum (SR) Ca ²⁺ handling proteins. Deficient S-nitrosylation of the cardiac ryanodine receptor (RyR2) has a variable effect on SR Ca ²⁺ leak/sparks in isolated myocytes, likely dependent on the underlying physiological state. It remains unknown, however, whet ...
- DOI:
- 10.1073/pnas.1210565109
- PubMed:
- 23071315
- PubMed Central:
- PMC3497770
- https://doi.org/10.1073/pnas.1210565109
- Author:
- RUQAIYYAH SIDDIQUI; RICKY DUDLEY; NAVEED AHMED KHAN
- Source:
- Parasitology 2012 v.139 no.7 pp. 826-834
- ISSN:
- 1469-8161
- Subject:
- Acanthamoeba; animal and human health; biochemical pathways; cell differentiation; death; drug therapy; evolution; genome; phenotype; protists
- Abstract:
- ... The ability of cyst-forming protists such as Acanthamoeba to escape death by transforming into a cyst form, that is resistant to harsh physiological, environmental and pharmacological conditions, has continued to pose a serious challenge to human and animal health. A complete understanding of the fundamental principles of genome evolution and biochemical pathways of cellular differentiation offers ...
- DOI:
- 10.1017/S0031182012000042
- PubMed:
- 22309612
- https://doi.org/10.1017/S0031182012000042
- Author:
- Sylwia Krzymińska; Hanna Frąckowiak; Adam Kaznowski
- Source:
- Current microbiology 2012 v.65 no.3 pp. 319-329
- ISSN:
- 0343-8651
- Subject:
- Acinetobacter; DNA fragmentation; apoptosis; chromatin; cytotoxicity; death; epithelial cells; humans; membrane potential; mitochondria; nitric oxide; nuclear genome; reactive oxygen species
- Abstract:
- ... We investigated interactions of human isolates of Acinetobacter calcoaceticus–baumannii complex strains with epithelial cells. The results showed that bacterial contact with the cells as well as adhesion and invasion were required for induction of cytotoxicity. The infected cells revealed hallmarks of apoptosis characterized by cell shrinking, condensed chromatin, and internucleosomal fragmentatio ...
- DOI:
- 10.1007/s00284-012-0159-7
- PubMed:
- 22684803
- PubMed Central:
- PMC3401494
- https://doi.org/10.1007/s00284-012-0159-7
- Author:
- Lin Victor Chia-Hsiang; Tsai Ya-Chu; Lin Jia-Ni; Fan Ling-Ling; Pan Min-Hsiung; Ho Chi-Tang; Wu Jiumn-Yih; Way Tzong-Der
- Source:
- Journal of agricultural and food chemistry 2012 v.60 no.25 pp. 6399-6407
- ISSN:
- 1520-5118
- Subject:
- acetyl-CoA carboxylase; apoptosis; chemoprevention; death; dietary exposure; epidemiological studies; fatty-acid synthase; fruits; grapes; humans; interphase; lipogenesis; men; prostatic neoplasms; risk; small fruits; stilbenes; vegetables
- Abstract:
- ... Prostate cancer is one of the leading causes of cancer death in men in Western countries. Epidemiological studies have linked the consumption of fruits and vegetables to a reduced risk of prostate cancer, and small fruits are particularly rich sources of many active phytochemical stilbenes, such as pterostilbene. As a constituent of small fruits such as grapes, berries, and their products, pterost ...
- DOI:
- 10.1021/jf301499e
- PubMed:
- 22670709
- https://doi.org/10.1021/jf301499e
- Author:
- Heather Waldeck; Xintong Wang; Evan Joyce; Weiyuan John Kao
- Source:
- Biomaterials 2012 v.33 no.1 pp. 29-37
- ISSN:
- 0142-9612
- Subject:
- apoptosis; biocompatible materials; death; hydrocolloids; in vitro studies; inflammation; macrophages; monocytes; necrosis; tissue repair; tumor necrosis factor-alpha
- Abstract:
- ... Monocytes/Macrophages have long been recognized as key players in inflammation and wound healing and are often employed in vitro to gain an understanding of the inflammatory response to biomaterials. Previous work has demonstrated a drastic decrease in primary monocyte adherent density on biomaterial surfaces coupled with a change in monocyte behavior over time. However, the mechanism responsible ...
- DOI:
- 10.1016/j.biomaterials.2011.09.044
- PubMed:
- 21963150
- PubMed Central:
- PMC3281311
- https://doi.org/10.1016/j.biomaterials.2011.09.044
- Author:
- Maria del Carmen Romero; Adela Valero; Joaquina Martín-Sánchez; María Concepción Navarro-Moll
- Source:
- Phytomedicine 2012 v.19 no.6 pp. 520-523
- ISSN:
- 0944-7113
- Subject:
- Anisakis; Matricaria chamomilla; active ingredients; alpha-bisabolol; anisakiasis; death; essential oils; in vitro studies; in vivo studies; intestines; larvae; larvicides; pathogens; rats; synergism
- Abstract:
- ... The increase in diagnosed cases of anisakiasis and the virtual absence of effective treatments have prompted the search for new active compounds against Anisakis L₃ larvae. The biocidal efficacy against different pathogens shown by various essential oils (EO) led us to study the Matricaria chamomilla EO and two of its main components (chamazulene and α-bisabolol) against the L₃ larvae of Anisakis ...
- DOI:
- 10.1016/j.phymed.2012.02.005
- https://doi.org/10.1016/j.phymed.2012.02.005
- Author:
- Emanuela Di Campli; Soraya Di Bartolomeo; Patricia Delli Pizzi; Mara Di Giulio; Rossella Grande; Antonia Nostro; Luigina Cellini
- Source:
- Parasitology research 2012 v.111 no.5 pp. 1985-1992
- ISSN:
- 0932-0113
- Subject:
- Melaleuca alternifolia; Pediculus humanus capitis; adults; death; developed countries; eggs; essential oils; hatching; lice; light microscopes; monitoring; mortality; nymphs; oils; pediculosis; school children; social problems; tea; trees; Italy
- Abstract:
- ... Head lice infestation is an emerging social problem in undeveloped and developed countries. Because of louse resistance increasing, several long-used insecticidal compounds have lost their efficacy, and alternatives, such as essential oils, have been proposed to treat this parasitic infestation. The present study investigated the efficacy of two natural substances: tea tree (Melaleuca alternifolia ...
- DOI:
- 10.1007/s00436-012-3045-0
- PubMed:
- 22847279
- PubMed Central:
- PMC3480584
- https://doi.org/10.1007/s00436-012-3045-0
- Author:
- F. A. Uzal; M. Mukai; L. Woods; R. Poppenga; B. A.Valentine; J. Smith
- Source:
- Veterinary pathology v.49 no.6 pp. 1070-1073
- ISSN:
- 1544-2217
- Subject:
- Camelidae; alpacas; animal pathology; atrophy; death; diaphragm; distress; etiology; histology; nerve tissue; paralysis; peripheral nervous system diseases; spinal cord
- Abstract:
- ... An alpaca was presented with a history of respiratory difficulty and death. Histology of the phrenic nerves and diaphragm revealed degenerative changes consistent with denervation atrophy, and a diagnosis of diaphragmatic paralysis was established. No gross or histological abnormalities were observed in the spinal cord or other organs. The etiology of the phrenic nerve neuropathy could not be dete ...
- DOI:
- 10.1177/0300985812447825
- https://doi.org/10.1177/0300985812447825
- Author:
- Meng Wang; Jin Liu; Bo Zhou; Rui Xu; Li Tao; Meilin Ji; Liping Zhu; Juan Jiang; Jiao Shen; Xiaolong Gui; Leilei Gu; Wenxia Bai; Wu Sun; Jianming Cheng
- Source:
- Journal of ethnopharmacology 2012 v.141 no.1 pp. 96-103
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Salvia miltiorrhiza; acute toxicity; adverse effects; animal behavior; animal tests; bilirubin; cardiovascular diseases; death; females; food consumption; food intake; hematologic tests; histopathology; inflammation; injection site; intravenous injection; lipid metabolism; males; mortality; no observed adverse effect level; product safety; rats; signs and symptoms (animals and humans); subchronic toxicity; tissue weight; toxicity testing; triacylglycerols; weight gain; China
- Abstract:
- ... ETHNOPHARMACOLOGICAL RELEVANCE: Salvia miltiorrhiza Bunge named Danshen in China has been used for hundreds of years in both China and other countries. Danshen injection made from the aqueous extract of Danshen which is widely adopted in China is one of the traditional Chinese medicine injections for preventing and treating cardiovascular diseases in most of the time. The present study was carried ...
- DOI:
- 10.1016/j.jep.2012.02.005
- PubMed:
- 22343168
- https://doi.org/10.1016/j.jep.2012.02.005
- Author:
- Marcelo Perim Baldo; Anna Késia Guerrat Teixeira; Sérgio Lamêgo Rodrigues; José Geraldo Mill
- Source:
- Food and chemical toxicology 2012 v.50 no.3-4 pp. 473-477
- ISSN:
- 0278-6915
- Subject:
- coronary vessels; death; diet; drinking water; electrocardiography; hypertrophy; infarction; myocardial infarction; rats; risk factors; sodium chloride; surgery; systolic blood pressure; toxicology
- Abstract:
- ... A high salt diet is a known risk factor for cardiovascular diseases that leads to cardiac hypertrophy and creates a substrate for arrhythmias and sudden death. However, acute arrhythmogenesis after infarction has not been studied. Male Wistar rats (21days) received drinking water (MI) or 1% NaCl solution (MI-Salt-C) for 4weeks. Water was given to another group for 4weeks, and on the day before sur ...
- DOI:
- 10.1016/j.fct.2011.11.033
- https://doi.org/10.1016/j.fct.2011.11.033
- Author:
- Leonidas Carrasco-Letelier; Yamandú Mendoza-Spina; María Belén Branchiccela
- Source:
- Chemosphere 2012 v.88 no.4 pp. 439-444
- ISSN:
- 0045-6535
- Subject:
- European Union; acute toxicity; apiculture; beekeepers; bioassays; chlorpyrifos; crops; cypermethrin; death; endosulfan; guidelines; honey; honey bees; lethal dose 50; normal values; poisoning; risk; soybeans; toxicity testing; Uruguay
- Abstract:
- ... Glyphosate-resistant soybean cultivation is expanding rapidly in Uruguay, with its land area having increased by 95 times during the past 10years. Because of the region’s Neotropical conditions, insecticide use is required to ensure adequate soybean productivity. However, in areas shared by soybean crops and beekeepers – such as the southwestern zone of Uruguay (SWZU) – the use of insecticides can ...
- DOI:
- 10.1016/j.chemosphere.2012.02.062
- PubMed:
- 22440636
- https://doi.org/10.1016/j.chemosphere.2012.02.062
- Author:
- D. Wang; X. Jia; R. She; Y. Liu
- Source:
- Poultry science 2012 v.91 no.2 pp. 334-339
- ISSN:
- 0032-5791
- Subject:
- Infectious bursal disease virus; chickens; death; eosinophils; inflammation; mast cells; mortality; tryptase
- Abstract:
- ... Very virulent infectious bursal disease virus (vvIBDV) can cause systemic inflammatory syndromes and acute death in specific-pathogen-free chickens within 72 h. However, the subtle mechanism of these severe inflammatory responses has been unsatisfactorily resolved until now. This study determined the kinetics of mast cells, tryptase, eosinophilic major basic protein, and eotaxin expression in spec ...
- DOI:
- 10.3382/ps.2010-01203
- PubMed:
- 22252345
- https://doi.org/10.3382/ps.2010-01203
- Author:
- Adenike Kuku; Racheal A. Togun; Efere M. Obuotor; David O. Adeyemi
- Source:
- Toxicological and environmental chemistry 2012 v.94 no.3 pp. 583-592
- ISSN:
- 1029-0486
- Subject:
- acute toxicity; administered dose; body weight changes; death; histopathology; kidneys; lectins; lethal dose 50; liver; lungs; mice; mortality; poisoning; salivation; seeds; spleen; toxicity testing
- Abstract:
- ... A lactose-binding lectin (TCL) was purified from the seeds of African walnut, Tetracarpidium conophorum, and acute toxicity studies of the lectin were carried out with Swiss albino male mice. Animals were administered doses of TCL from 500 to 2500 mg kg⁻¹ body weight (b.wt.) orally while intraperitoneally the dose ranged from 10 to 600 mg kg⁻¹ b.wt. Animals were then assessed for organ and body we ...
- DOI:
- 10.1080/02772248.2011.649037
- https://doi.org/10.1080/02772248.2011.649037
- Author:
- Zhibing Jiang; Yijun Huang; Quanzhen Chen; Jiangning Zeng; Xiaoqun Xu
- Source:
- Marine environmental research 2012 v.81 no. pp. 12-17
- ISSN:
- 0141-1136
- Subject:
- Copepoda; accidents; acclimation; acute toxicity; body size; coma; death; exposure duration; lethal concentration 50; marine science; oils; petroleum; risk; swimming; East China Sea
- Abstract:
- ... Recent oil spillage accidents around the world greatly increase harmful risks to marine ecology. This study evaluated the influences of petroleum water accommodated fraction (WAF) on 15 typical species of marine copepods collected from a subtropical bay in East China Sea at different seasons. Copepods showed impaired swimming ability, restlessness, loss of balance, anoxic coma, and even death when ...
- DOI:
- 10.1016/j.marenvres.2012.08.003
- PubMed:
- 22921874
- https://doi.org/10.1016/j.marenvres.2012.08.003
- Author:
- Harbindar Jeet Singh; Lee Siew Keah; Arun Kumar; K.N.S. Sirajudeen
- Source:
- Experimental and toxicologic pathology 2012 v.64 no.7-8 pp. 751-752
- ISSN:
- 0940-2993
- Subject:
- adverse effects; blood pressure; body weight; death; drinking water; melatonin; morbidity; mortality; pregnancy; pups; rats
- Abstract:
- ... This report documents an incidental finding during a study investigating the effects of melatonin supplementation on the development of blood pressure in SHR. Administration of 10mg/kg/day of melatonin in drinking water during pregnancy to Wistar-Kyoto (WKY) dams caused a loss of more than 50% of the pups by the age of three weeks and 95% by the age of 6 weeks. There was no maternal morbidity or m ...
- DOI:
- 10.1016/j.etp.2011.01.011
- https://doi.org/10.1016/j.etp.2011.01.011
- Author:
- Phyllis C. Lee; Soila Sayialel; W. Keith Lindsay; Cynthia J. Moss
- Source:
- African journal of ecology 2012 v.50 no.1 pp. 9-20
- ISSN:
- 0141-6707
- Subject:
- Loxodonta africana; age determination; calves; death; jaws; longevity; models; mortality; teeth; weathering
- Abstract:
- ... We assess tooth‐based age criteria for African elephants developed by Laws in relation to known‐aged individuals in the Amboseli elephant population. Laws’s technique remains a robust and useful mechanism for age determination, although we suggest revisions to the oldest age categories. Blind age assignment to jaws of unknown sex using the Laws criteria resulted in misclassification of M4 and M5; ...
- DOI:
- 10.1111/j.1365-2028.2011.01286.x
- https://doi.org/10.1111/j.1365-2028.2011.01286.x
- Author:
- Addesso Karla M.; Mcauslane Heather J.; Cherry Ron
- Source:
- Environmental entomology 2012 v.41 no.4 pp. 887-895
- ISSN:
- 0046-225X
- Subject:
- grasses; Blissus leucopterus; aggregation behavior; Blissus insularis; males; lawns and turf; olfactometers; bioassays; paper; sap; leaves; nymphs; Stenotaphrum secundatum; death; odors; females; adults
- Abstract:
- ... The southern chinch bug, Blissus insuhris Barber, forms dense, multigenerational aggregations in St. Augustinegrass lawns leading to grass death from sap feeding. We conducted laboratory bioassays to better understand the signals responsible for the formation and maintenance of southern chinch bug aggregations. In small arena assays, chinch bugs demonstrated a stronger aggregation response over ti ...
- DOI:
- 10.1603/EN11145
- https://doi.org/10.1603/EN11145
- Author:
- Frederick W. Lipfert; Christian J. Murray
- Source:
- Atmospheric environment 2012 v.55 no. pp. 467-474
- ISSN:
- 1352-2310
- Subject:
- air pollution; air quality; ambient temperature; atmospheric chemistry; death; elderly; exposure duration; longevity; models; morbidity; mortality; ozone; particulates; people; population size; premature birth; public health; risk
- Abstract:
- ... Many time-series studies find associations between acute health effects and ambient air quality under current conditions. However, few such studies link mortality with morbidity to provide rational bases for improving public health. This paper describes a research project that developed and validated a new modeling approach directly addressing changes in life expectancies and the prematurity of de ...
- DOI:
- 10.1016/j.atmosenv.2012.03.013
- https://doi.org/10.1016/j.atmosenv.2012.03.013
- Author:
- Erica L. Seubert; Shane Trussell; John Eagleton; Astrid Schnetzer; Ivona Cetinić; Phil Lauri; Burton H. Jones; David A. Caron
- Source:
- Water research 2012 v.46 no.19 pp. 6563-6573
- ISSN:
- 0043-1354
- Subject:
- algal blooms; death; desalination; domoic acid; human health; laboratory experimentation; microalgae; monitoring; neurotoxins; okadaic acid; phycotoxins; reverse osmosis; seafoods; seawater; water supply; California
- Abstract:
- ... The occurrence and intensity of harmful algal blooms (HABs) have been increasing globally during the past few decades. The impact of these events on seawater desalination facilities has become an important topic in recent years due to enhanced societal interest and reliance on this technology for augmenting world water supplies. A variety of harmful bloom-forming species of microalgae occur in sou ...
- DOI:
- 10.1016/j.watres.2012.09.042
- PubMed:
- 23079130
- https://doi.org/10.1016/j.watres.2012.09.042
- Author:
- Sharon D. Huff; Paul K. McGaha; Marie Reed; Marshall Kratz; Jo Ann Peters; Virginia Atkinson
- Source:
- Journal of agromedicine 2012 v.17 no.1 pp. 51-62
- ISSN:
- 1545-0813
- Subject:
- all-terrain vehicles; children; death; geographic information systems; head; health services; planning; Texas
- Abstract:
- ... The state of Texas was ranked 10th for all-terrain vehicle-related deaths among all states from 2007–2009. Health Service Region 4/5N of eastern Texas has a statistically significant higher rate of all-terrain vehicle-related injuries in children under the age of 18 than Texas as a whole (p < 0.001.) It is unknown why east Texas has a higher all-terrain vehicle-related injury rate. A retrospective ...
- DOI:
- 10.1080/1059924X.2012.632206
- https://doi.org/10.1080/1059924X.2012.632206
- Author:
- Danielle K. Rajani; Michael Walch; Denis Martinvalet; Marshall P. Thomas; Judy Lieberman
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.22 pp. 8688-8693
- ISSN:
- 0027-8424
- Subject:
- RNA; RNA-binding proteins; apoptosis; death; physiological transport; protein synthesis; proteinases; proteomics; ribonucleoproteins
- Abstract:
- ... During immune-mediated death, death-inducing granzyme (Gzm) proteases concentrate in the nucleus of cells targeted for immune elimination, suggesting that nuclear processes are important targets. Here we used differential 2D proteomics of GzmA-treated nuclei to identify potential GzmA substrates. Of 44 candidates, 33 were RNA-binding proteins important in posttranscriptional RNA processing, includ ...
- DOI:
- 10.1073/pnas.1201327109
- PubMed:
- 22589304
- PubMed Central:
- PMC3365155
- https://doi.org/10.1073/pnas.1201327109
- Author:
- Chunxue Yang; Haibing Yang; Shu Guo; Zongshuang Wang; Xiaohui Xu; Xiaoli Duan; Haidong Kan
- Source:
- Science of the total environment 2012 v.426 no. pp. 83-89
- ISSN:
- 0048-9697
- Subject:
- acute effects; air pollution; cardiovascular diseases; cities; death; developing countries; educational status; human health; models; mortality; ozone; warm season; China
- Abstract:
- ... Controversy remains regarding the relationship between various metrics of ozone (O₃) and mortality. In China, the largest developing country, there have been few studies investigating the acute effect of O₃ on death. We used three exposure metrics of O₃ (1-hour maximum, maximum 8-hour average and 24-hour average) to examine its short-term association with daily mortality in Suzhou, China. We used ...
- DOI:
- 10.1016/j.scitotenv.2012.03.036
- PubMed:
- 22521098
- https://doi.org/10.1016/j.scitotenv.2012.03.036
- Author:
- Mok Mai Yee; Leslie W. Woods; Robert H. Poppenga; Birgit Puschner
- Source:
- Journal of veterinary diagnostic investigation v.24 no.1 pp. 241-244
- ISSN:
- 1943-4936
- Subject:
- alpha-amanitin; beef; calves; cows; death; herds; histopathology; ingestion; liver; mass spectrometry; mushroom poisoning; mushrooms; necrosis; nephrosis; rumen; selenium; tissue analysis; urine; zinc; California
- Abstract:
- ... Two 2- and 3-month-old beef calves from 2 separate herds, locations, and times were found dead and were submitted to the veterinary diagnostic laboratory for diagnostic work-up. In both cases, no premonitory signs were seen by the owners. Histopathology revealed acute panlobular hepatic necrosis in both calves. In addition, calf A had copper and selenium deficiency, and calf B had oxalate nephrosi ...
- DOI:
- 10.1177/1040638711427947
- https://doi.org/10.1177/1040638711427947
- Author:
- Geoffrey M. Attardo; Joshua B. Benoit; Veronika Michalkova; Guangxiao Yang; Ladislav Roller; Jana Bohova; Peter Takáč; Serap Aksoy
- Source:
- Insect biochemistry and molecular biology 2012 v.42 no.5 pp. 360-370
- ISSN:
- 0965-1748
- Subject:
- Glossina morsitans; adipokinetic hormone; biochemical pathways; body fat; death; fecundity; genes; gonotrophic cycle; instars; lactation; larvae; larval development; lipids; lipolysis; longevity; malnutrition; mammals; milk; milk production; models; oocytes; phenotype; pregnancy; small interfering RNA; starvation; triacylglycerol lipase
- Abstract:
- ... Female tsetse flies undergo viviparous reproduction, generating one larva each gonotrophic cycle. Larval nourishment is provided by the mother in the form of milk secretions. The milk consists mostly of lipids during early larval development and shifts to a balanced combination of protein and lipids in the late larval instars. Provisioning of adequate lipids to the accessory gland is an indispensa ...
- DOI:
- 10.1016/j.ibmb.2012.01.007
- https://doi.org/10.1016/j.ibmb.2012.01.007
30. Analysis on outcome of 5284 patients with coronary artery disease: The role of integrative medicine
- Author:
- Zhu-ye Gao; Hao Xu; Da-zhuo Shi; Chuan Wen; Bao-yan Liu
- Source:
- Journal of ethnopharmacology 2012 v.141 no.2 pp. 578-583
- ISSN:
- 0378-8741
- Subject:
- Carthamus tinctorius; Pinellia; Poria; Salvia miltiorrhiza; blood; cholesterol; coronary vessels; death; drug therapy; guidelines; heart; herbs; high density lipoprotein; hospitals; hyperlipidemia; hypertension; low density lipoprotein; mechanism of action; mortality; myocardial infarction; patients; peaches; prognosis; regression analysis; risk factors; seeds; systolic blood pressure; traditional medicine; triacylglycerols; China
- Abstract:
- ... ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese Medicine (TCM) has a history of thousands of years and has made great contributions to the health and well-being of the people. Integrative medicine (IM) treatment, combing TCM and conventional medicine, has been the most representative characteristic for coronary artery disease (CAD) patients in China, especially those in IM hospitals. However, ...
- DOI:
- 10.1016/j.jep.2011.08.071
- PubMed:
- 21924336
- https://doi.org/10.1016/j.jep.2011.08.071
- Author:
- Michael J. Walker; Peter Colwell; Derek Craston; Ian P. Axford; Jack Crane
- Source:
- Food analytical methods 2012 v.5 no.1 pp. 54-61
- ISSN:
- 1936-9751
- Subject:
- European Union; additives; case studies; children; death; elderly; food analysis; jellies; mouth; people; risk; saliva
- Abstract:
- ... There have been several instances worldwide of children and elderly people choking to death on soft slippery dome-shaped jellies that are designed to be placed in the mouth in one bite. This problem was addressed in the European Union by the provisions of Directive 2006/52/EC of the European Parliament and of the Council prohibiting the use of a range of gel-forming additives in jelly mini-cups. U ...
- DOI:
- 10.1007/s12161-011-9223-3
- https://doi.org/10.1007/s12161-011-9223-3
- Author:
- Daniel C. Fisher; Alexei N. Tikhonov; Pavel A. Kosintsev; Adam N. Rountrey; Bernard Buigues; Johannes van der Plicht
- Source:
- Quaternary international 2012 v.255 no. pp. 94-105
- ISSN:
- 1040-6182
- Subject:
- adults; asphyxia; bacteria; bones; bronchi; brown adipose tissue; calves; carbon; cliffs; collagen; coprophagy; death; feces; hemoglobin; intestines; iron; iron phosphates; lactic acid; mastication; metabolites; milk; neck; neonates; permafrost; physiological response; plant tissues; radiocarbon dating; spring; subcutaneous fat; thermoregulation; vasoconstriction; Siberia
- Abstract:
- ... A well-preserved woolly mammoth calf found in northwest Siberia offers unique opportunities to investigate mammoth anatomy, behavior, life history and taphonomy. Analysis of the fluvial setting where the specimen was found suggests it was derived from eroding bluffs during ice-out flooding in June 2006. It then lay exposed on a point-bar surface until recovery the following May. AMS dating of bone ...
- DOI:
- 10.1016/j.quaint.2011.05.040
- https://doi.org/10.1016/j.quaint.2011.05.040
- Author:
- X. Fang; J. Shi; X. Song; A. Mitnitski; Z. Tang; C. Wang; P. Yu; Kenneth Rockwood
- Source:
- journal of nutrition, health & aging 2012 v.16 no.10 pp. 903-907
- ISSN:
- 1279-7707
- Subject:
- Chinese people; bone fractures; cohort studies; confidence interval; death; elderly; functional status; longitudinal studies; mortality; regression analysis; risk; statistical models; China
- Abstract:
- ... OBJECTIVES: Falls are well known to be associated with adverse health outcomes, especially when complicated by fracture. Falls are more common in people who are frail and readily related to several items in the frailty phenotype. Less is known about the relationship between falls and frailty defined as deficit accumulation. Our objective was to investigate the relationship between falls, fractures ...
- DOI:
- 10.1007/s12603-012-0368-6
- https://doi.org/10.1007/s12603-012-0368-6
- Author:
- Ilias Chaligiannis; Marco Lalle; Edoardo Pozio; Smaragda Sotiraki
- Source:
- Veterinary parasitology 2012 v.184 no.2-4 pp. 362-366
- ISSN:
- 0304-4017
- Subject:
- Anisakis; Hysterothylacium; death; humans; hybrids; hypersensitivity; larvae; marine fish; people; raw fish; Aegean Sea
- Abstract:
- ... Nematode worms of the family Anisakidae are the causative agents of infections in humans when fish is consumed raw and of serious allergies up to the death, when fish is consumed raw or cooked by previously sensitized people. From April until November 2009, 462 fish belonging to 26 species, fished in three areas of the Aegean Sea were tested for Anisakidae larvae. Anisakidae larvae were detected i ...
- DOI:
- 10.1016/j.vetpar.2011.09.007
- PubMed:
- 22030376
- https://doi.org/10.1016/j.vetpar.2011.09.007
- Author:
- Niaz Ali; Syed Wadood Ali Shah; Ismail Shah; Ghayour Ahmed; Mehreen Ghias; Imran Khan; Waqar Ali
- Source:
- BMC complementary and alternative medicine 2012 v.12 no.1 pp. 29
- ISSN:
- 1472-6882
- Subject:
- Ascaridia galli; Raillietina; Verbascum thapsus; albendazole; alternative medicine; atropine; calcium; calcium chloride; death; flavonoids; jejunum; lipids; mechanism of action; median effective concentration; medicine; oils; paralysis; plant extracts; potassium chloride; proteins; rabbits; saponins; tannins; tapeworms; terpenoids; verapamil; Pakistan
- Abstract:
- ... BACKGROUND: Verbascum thapsus is used in tribal medicine as an antispasmodic, anti-tubercular agent and wormicide. In this study, we investigated the antispasmodic and anthelmintic activities of crude aqueous methanolic extract of the plant. METHODS: V. thapsus extracts were tested against roundworms (Ascaridia galli) and tapeworms (Raillietina spiralis). Each species of worm was placed into a neg ...
- DOI:
- 10.1186/1472-6882-12-29
- PubMed:
- 22463730
- PubMed Central:
- PMC3350428
- https://doi.org/10.1186/1472-6882-12-29
36. Anthelmintic effect of a methanol extract of Bombax malabaricum leaves on Paramphistomum explanatum
- Author:
- Emdad Hossain; Goutam Chandra; Anadi P. Nandy; Subhash C. Mandal; Jayanta Kumar Gupta
- Source:
- Parasitology research 2012 v.110 no.3 pp. 1097-1102
- ISSN:
- 0932-0113
- Subject:
- Bombax ceiba; Paramphistomum; albendazole; buffaloes; color; death; leaves; methanol; paralysis; parasites; traditional medicine; Pakistan
- Abstract:
- ... Bombax malabaricum (family Bombacaceae) is used as anthelmintic in traditional system of medicine in Southern Punjab of Pakistan. The objective of this study was to evaluate the anthelmintic activity of the methanol extract of B. malabaricum leaves (MEBM). Live parasites (trematode: Paramphistomum explanatum) were collected from buffalo in 0.9% phosphate-buffered saline. It was incubated in Petri ...
- DOI:
- 10.1007/s00436-011-2594-y
- PubMed:
- 21853226
- https://doi.org/10.1007/s00436-011-2594-y
37. Anthelmintic effect of a methanol extract of leaves of Dregea volubilis on Paramphistomum explanatum
- Author:
- Emdad Hossain; Goutam Chandra; Anadi P. Nandy; Subhash C. Mandal; Jayanta Kumar Gupta
- Source:
- Parasitology research 2012 v.110 no.2 pp. 809-814
- ISSN:
- 0932-0113
- Subject:
- Paramphistomum; albendazole; buffaloes; death; leaf extracts; leaves; methanol; paralysis; parasites; traditional medicine; India
- Abstract:
- ... Dregea volubilis (family Asclepediaceae) is widely used as anthelmintic in traditional system of medicine in eastern and southern part of India. The aim of this study was to evaluate the anthelmintic activity of the methanol extract of D. volubilis leaves (MEDV) and to observe its effect through SEM study. Live parasites (trematode Paramphistomum explanatum) were collected from buffalo in 0.9% pho ...
- DOI:
- 10.1007/s00436-011-2558-2
- PubMed:
- 21789584
- https://doi.org/10.1007/s00436-011-2558-2
- Author:
- Georg von Samson-Himmelstjerna
- Source:
- Veterinary parasitology 2012 v.185 no.1 pp. 2-8
- ISSN:
- 0304-4017
- Subject:
- Cyathostominae; Parascaris equorum; benzimidazoles; death; developed countries; farms; foals; immunity; moxidectin; parasites; pasture management; pyrantel; small intestine
- Abstract:
- ... During the past two decades anthelmintic resistance in equine parasites has been found in the group of small strongyle species (cyathostomins) and in the ascarid species Parascaris equorum. The ubiquitous nature and possible severe consequences of disease with these nematodes make them the prime targets of current worm control programmes. Traditional control strategies mainly rely on the strategic ...
- DOI:
- 10.1016/j.vetpar.2011.10.010
- PubMed:
- 22100141
- https://doi.org/10.1016/j.vetpar.2011.10.010
- Author:
- Fernanda Guilhon-Simplicio; Carlos Cleomir de Souza Pinheiro; Gabrielly Galdino Conrado; Gleyce dos Santos Barbosa; Pierre Alexandre dos Santos; Maria de Meneses Pereira; Emerson Silva Lima
- Source:
- Journal of ethnopharmacology 2012 v.140 no.2 pp. 282-286
- ISSN:
- 0378-8741
- Subject:
- Byrsonima; anti-inflammatory activity; anti-ulcer activity; antioxidant activity; bark; death; drugs; humans; mice; rats; screening; stems; toxicity
- Abstract:
- ... ETHNOPHARMACOLOGICAL RELEVANCE: Decoctions or infusions of the stem bark of Byrsonima japurensis A. Juss. (Malpighiaceae) are widely used as an anti-inflammatory drug in folk medicine of Amazonas State (Brazil). AIM OF THE STUDY: To evaluate the pharmacological potential of an aqueous extract of the stem bark of Byrsonima japurensis (BJEA) to scientifically verify of its traditional use. MATERIALS ...
- DOI:
- 10.1016/j.jep.2012.01.018
- PubMed:
- 22289348
- https://doi.org/10.1016/j.jep.2012.01.018
- Author:
- Avelina Espinosa; Aaron M. Socha; Erica Ryke; David C. Rowley
- Source:
- Parasitology research 2012 v.111 no.6 pp. 2473-2477
- ISSN:
- 0932-0113
- Subject:
- Actinomycetales; Entamoeba histolytica; amebiasis; antibiotics; bacteria; death; drug resistance; metronidazole; pathogens; people; secondary metabolites; toxicity; Colombia
- Abstract:
- ... Entamoeba histolytica infects 50 million people per year, causing 100,000 deaths worldwide. The primary treatment for amoebiasis is metronidazole. However, increased pathogen resistance combined with the drug’s toxic side effects encourages a search for alternative therapeutic agents. Secondary metabolites from marine bacteria are a promising resource for antiprotozoan drug discovery. In this stud ...
- DOI:
- 10.1007/s00436-012-3019-2
- PubMed:
- 22763704
- PubMed Central:
- PMC3491104
- https://doi.org/10.1007/s00436-012-3019-2
41. Anticancer activity of undecapeptide analogues derived from antimicrobial peptide, Brevinin-1EMa
- Author:
- Su-Jin Kang; Hye-Young Ji; Bong-Jin Lee
- Source:
- Archives of pharmacal research 2012 v.35 no.5 pp. 791-799
- ISSN:
- 0253-6269
- Subject:
- anti-infective properties; anticarcinogenic activity; antimicrobial peptides; colon; death; doxorubicin; kidneys; mechanism of action; molecular weight; neoplasm cells; stomach; synergism; therapeutics
- Abstract:
- ... In spite of great advances in cancer therapy, cancer remains the major cause of death throughout the world. The increasing resistance of cancer cells towards current anticancer drugs requires development of anticancer agents with a new mode of action. Some antimicrobial peptides have become therapeutic candidates as new anticancer agents. As part of an effort to develop new antimicrobial and/or an ...
- DOI:
- 10.1007/s12272-012-0505-0
- https://doi.org/10.1007/s12272-012-0505-0
- Author:
- Santiagu Stephen Irudayaraj; Christudas Sunil; Veeramuthu Duraipandiyan; Savarimuthu Ignacimuthu
- Source:
- Journal of ethnopharmacology 2012 v.143 no.2 pp. 515-523
- ISSN:
- 0378-8741
- Subject:
- acetates; acute toxicity; alkaloids; antioxidant activity; blood glucose; body weight; death; diabetes; gallic acid; glucose; glucose tolerance; glycogen; hexane; high performance liquid chromatography; histopathology; insulin; leaves; liver; methanol; pancreas; rats; screening; streptozotocin; superoxide dismutase; terpenoids
- Abstract:
- ... ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Toddalia asiatica (L.) Lam. have been utilized traditionally for the cure of diabetes. AIM OF THE STUDY: The present study was aimed to assess the antidiabetic and antioxidant effects of T. asiatica leaves in Streptozotocin (STZ) induced diabetic rats. MATERIALS AND METHODS: The phytochemical screening, total phenolic content, HPLC analysis, acute toxi ...
- DOI:
- 10.1016/j.jep.2012.07.006
- PubMed:
- 22842651
- https://doi.org/10.1016/j.jep.2012.07.006
- Author:
- Eun-Jung Park; Hyen Joo Park; Hwa-Jin Chung; Yoonho Shin; Hye-Young Min; Ji-Young Hong; You-Jin Kang; Yong-Hyun Ahn; Jae-Ho Pyee; Sang Kook Lee
- Source:
- Journal of nutritional biochemistry 2012 v.23 no.8 pp. 946-952
- ISSN:
- 0955-2863
- Subject:
- Pinus; body weight; cell cycle; chemoprevention; colorectal neoplasms; death; fibrosarcoma; gelatinase A; humans; intraperitoneal injection; intravenous injection; metastasis; mice; models; patients; phosphorylation; tissue repair
- Abstract:
- ... Metastasis is a major cause of death in cancer patients. Our previous studies showed that pinosylvin, a naturally occurring trans-stilbenoid mainly found in Pinus species, exhibited a potential cancer chemopreventive activity and also inhibited the growth of various human cancer cell lines via the regulation of cell cycle progression. In this study, we further evaluated the potential antimetastati ...
- DOI:
- 10.1016/j.jnutbio.2011.04.021
- PubMed:
- 21937212
- https://doi.org/10.1016/j.jnutbio.2011.04.021
- Author:
- Hyemin Choi; Dong Gun Lee
- Source:
- Biochimica et biophysica acta 2012 v.1820 no.12 pp. 1831-1838
- ISSN:
- 0304-4165
- Subject:
- Enterococcus faecium; NAD (coenzyme); ampicillin; antibacterial properties; antimicrobial peptides; biofilm; cell membranes; death; drug therapy; erythromycin; fluorescein; hydroxyl radicals; oxidative stress; permeability; propidium; synergism; thiourea; tissue culture; viability
- Abstract:
- ... BACKGROUND: Pleurocidin, a 25-mer antimicrobial peptide (AMP), is known to exert bactericidal activity. However, the synergistic activity and mechanism(s) of pleurocidin in combination with conventional antibiotics, and the antibiofilm effect of the peptide are poorly understood. METHODS: The interaction between pleurocidin and antibiotics was evaluated using checkerboard assay. To study the mecha ...
- DOI:
- 10.1016/j.bbagen.2012.08.012
- https://doi.org/10.1016/j.bbagen.2012.08.012
- Author:
- C. Milani; M. Corrò; M. Drigo; A. Rota
- Source:
- Theriogenology 2012 v.78 no.6 pp. 1321-1328
- ISSN:
- 0093-691X
- Subject:
- Escherichia coli; Staphylococcus; Streptococcus canis; antibiotic resistance; antibiotics; bacteria; bitches; breeding; death; milk; neonatal mortality; risk; veterinarians; whelping
- Abstract:
- ... This work examines the antimicrobial resistance of potentially pathogenic bacteria (Staphylococcus pseudintermedius, Streptococcus canis, Escherichia coli) found in the vaginal tract in prepartum mammary secretions and postpartum milk of bitches housed in breeding kennels (N = 20; 92 bitches). The kennels were divided into three categories: no routine antimicrobial administration around parturitio ...
- DOI:
- 10.1016/j.theriogenology.2012.05.033
- PubMed:
- 22898018
- https://doi.org/10.1016/j.theriogenology.2012.05.033
- Author:
- Hassane Mekhfi; Fatima Belmekki; Abderrahim Ziyyat; Abdelkhaleq Legssyer; Mohamed Bnouham; Mohammed Aziz
- Source:
- Nutrition 2012 v.28 no.9 pp. 937-941
- ISSN:
- 0899-9007
- Subject:
- anticoagulant activity; blood vessels; clinical trials; coagulation; collagen; death; epinephrine; heparin; in vivo studies; intravenous injection; lungs; mice; models; nutrition; oils; oral administration; paralysis; platelet aggregation; prothrombin; rats; thrombin; thromboplastin; thrombosis; variance
- Abstract:
- ... OBJECTIVE: Argan oil has been shown to inhibit in vitro and ex vivo platelet aggregation without extending bleeding time. In this report, we examined in vivo the antithrombotic activity of argan oil in an experimental thrombosis model in mice: acute pulmonary thromboembolism and in vitro its effect in a coagulation assay. METHODS: Acute pulmonary thromboembolism was induced, after argan oil treatm ...
- DOI:
- 10.1016/j.nut.2011.11.032
- PubMed:
- 22465906
- https://doi.org/10.1016/j.nut.2011.11.032
- Author:
- Li-Fen Lee; Kathryn Logronio; Guang Huan Tu; Wenwu Zhai; Irene Ni; Li Mei; Jeanette Dilley; Jessica Yu; Arvind Rajpal; Colleen Brown; Charles Appah; Sherman Michael Chin; Bora Han; Timothy Affolter; John C. Lin
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.31 pp. 12674-12679
- ISSN:
- 0027-8424
- Subject:
- humans; T-lymphocytes; immunosuppression; antibodies; genetic variation; remission; therapeutics; mice; insulin-dependent diabetes mellitus; genes; interleukin-7; death; animal disease models
- Abstract:
- ... Genetic variation in the IL-7 receptor-α (IL-7R) gene is associated with susceptibility to human type 1 diabetes (T1D). Here we investigate the therapeutic efficacy and mechanism of IL-7Rα antibody in a mouse model of T1D. IL-7Rα antibody induces durable, complete remission in newly onset diabetic mice after only two to three injections. IL-7 increases, whereas IL-7Rα antibody therapy reduces, the ...
- DOI:
- 10.1073/pnas.1203795109
- PubMed:
- 22733769
- PubMed Central:
- PMC3412026
- https://doi.org/10.1073/pnas.1203795109
- Author:
- Mahmoud AbouLaila; Tserendorj Munkhjargal; Thillaiampalam Sivakumar; Akio Ueno; Yuki Nakano; Miki Yokoyama; Takeshi Yoshinari; Daisuke Nagano; Koji Katayama; Nasr El-Bahy; Naoaki Yokoyama; Ikuo Igarashi
- Source:
- Antimicrobial agents and chemotherapy 2012 v.56 no.6 pp. 3196-3206
- ISSN:
- 0066-4804
- Subject:
- Babesia bigemina; Babesia bovis; Babesia caballi; Babesia microti; DNA replication; Theileria equi; apicoplast DNA; babesiosis; body weight; ciprofloxacin; clindamycin; death; drug therapy; growth retardation; mice; parasitemia; parasites; reverse transcriptase polymerase chain reaction; thiostrepton; translation (genetics)
- Abstract:
- ... The apicoplast housekeeping machinery, specifically apicoplast DNA replication, transcription, and translation, was targeted by ciprofloxacin, thiostrepton, and rifampin, respectively, in the in vitro cultures of four Babesia species. Furthermore, the in vivo effect of thiostrepton on the growth cycle of Babesia microti in BALB/c mice was evaluated. The drugs caused significant inhibition of growt ...
- DOI:
- 10.1128/AAC.05488-11
- PubMed:
- 22391527
- PubMed Central:
- PMC3370714
- https://doi.org/10.1128/AAC.05488-11
- Author:
- Leong-Perng Chan; Tzung-Han Chou; Hsiou-Yu Ding; Pin-Ru Chen; Feng-Yu Chiang; Po-Lin Kuo; Chia-Hua Liang
- Source:
- Biochimica et biophysica acta 2012 v.1820 no.7 pp. 1081-1091
- ISSN:
- 0304-4165
- Subject:
- cell cycle checkpoints; cisplatin; reactive oxygen species; lipid peroxidation; chemoprevention; signal transduction; oxidative stress; protective effect; glutathione; cell viability; head; tumor necrosis factors; synergism; apoptosis; caspases; humans; fluorouracil; squamous cell carcinoma; mice; antioxidant activity; cell proliferation; liver; death; apigenin
- Abstract:
- ... BACKGROUND: Apigenin, a natural plant flavone, may have chemopreventive and therapeutic potentials for anti-inflammatory, antioxidant, and anti-cancer. Nevertheless, the anti-tumor effect of apigenin on human head and neck squamous cell carcinoma (HNSCC) is not fully understood. METHODS: The antioxidant capacity and protective effects of apigenin against oxidative stress in murine normal embryonic ...
- DOI:
- 10.1016/j.bbagen.2012.04.013
- https://doi.org/10.1016/j.bbagen.2012.04.013
- Author:
- CAMILA M. ADADE; GABRIELA S. F. CHAGAS; THAÏS SOUTO-PADRÓN
- Source:
- Parasitology 2012 v.139 no.11 pp. 1444-1461
- ISSN:
- 1469-8161
- Subject:
- Apis mellifera; Chagas disease; Trypanosoma cruzi; amastigotes; antineoplastic activity; apoptosis; autophagy; cadaverine; chromatin; death; drug therapy; epimastigotes; kinetoplast DNA; mammals; new drugs; organelles; phenotype; staining; toxicity; trypomastigotes; ultrastructure; venoms; viability
- Abstract:
- ... Chagas disease chemotherapy is based on drugs that exhibit toxic effects and have limited efficacy, such as Benznidazole. Therefore, research into new chemotherapeutic agents from natural sources needs to be exploited. Apis mellifera venom consists of many biologically active molecules and has been reported to exhibit remarkable anti-cancer effects, often promoting an apoptosis-like death phenotyp ...
- DOI:
- 10.1017/S0031182012000790
- PubMed:
- 23025900
- https://doi.org/10.1017/S0031182012000790