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- Krasilnikova, Maria M.; Kireeva, Maria L.; Petrovic, Vladimir; Knijnikova, Nelli; Kashlev, Mikhail; Mirkin, Sergei M.
- Nucleic acids research 2007 v.35 no.4 pp. 1075-1084
- messenger RNA; models; plasmids; dissociation; gene expression; transcription (genetics); neurodegenerative diseases; ataxia (disorder); DNA-directed RNA polymerase; introns; Escherichia coli
- ... Expansions of (GAA)n repeats within the first intron of the frataxin gene reduce its expression, resulting in a hereditary neurodegenerative disorder, Friedreich's ataxia. While it is generally believed that expanded (GAA)n repeats block transcription elongation, fine mechanisms responsible for gene repression are not fully understood. To follow the effects of (GAA)n·(TTC)n repeats on gene express ...
- PubMed Central:
- Chatterji, Dipankar; Ogawa, Yoshito; Shimada, Tomohiro; Ishihama, Akira
- FEMS microbiology letters 2007 v.267 no.1 pp. 51-55
- messenger RNA; starvation; stress response; DNA microarrays; gene expression; ribosomal proteins; operon; DNA-directed RNA polymerase; Escherichia coli
- ... The rpoZ gene for the omega subunit of Escherichia coli RNA polymerase constitutes single operon with the spoT gene, which is responsible for the maintenance of stringent response under nutrient starvation conditions. To identify the physiological role of the omega subunit, we compared the gene expression profile of wild-type Escherichia coli with that of an rpoZ deleted strain by microarray analy ...