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1. IL- 10 receptor blockade controls the in vitro infectivity of Leishmania infantum and promotes a Th1 activation in PBMC of dogs with visceral leishmaniasis

Author:
Jamille Mirelle de Oliveira Cardoso; Rory Cristiane Fortes de Brito; Ana Flávia Pereira Costa; Fernando Augusto Siqueira Mathias; Levi Eduardo Soares Reis; João Filipe Pereira Vieira; Rodrigo Dian de Oliveira Aguiar Soares; Alexandre Barbosa Reis; Bruno Mendes Roatt
Source:
Molecular immunology 2021 v.137 pp. 20-27
ISSN:
0161-5890
Subject:
Leishmania infantum; antigens; disease progression; dogs; humans; immune response; immunomodulation; interleukin-10; monoclonal antibodies; parasites; pathogenicity; risk reduction; therapeutics; visceral leishmaniasis
Abstract:
... An important strategy to reduce the risk of visceral leishmaniasis (VL) in humans is to control the infection and disease progression in dogs, the domestic reservoir of Leishmania infantum parasites. Certain therapeutic strategies that modulate the host immune response show great potential for the treatment of experimental VL, restoring the impaired effector functions or decreasing host excessive ...
DOI:
10.1016/j.molimm.2021.06.014

2. ADIPOR1 regulates genes involved in milk fat metabolism in goat mammary epithelial cells

Author:
Wangsheng Zhao; Michael Adjei; Hongmei Wang; Yueling Yangliu; Jiangjiang Zhu; Huijuan Wu
Source:
Research in veterinary science 2021 v.137 pp. 194-200
ISSN:
0034-5288
Subject:
adiponectin receptors; dry period (lactation); epithelium; genes; goat milk; goats; lactation; lipid metabolism; mammary glands; milk fat; research; veterinary medicine
Abstract:
... Fat metabolism is a complex process regulated by a number of factors. Adiponectin receptor 1 (ADIPOR1) gene takes active part in lipid metabolism. Although, there have been some researches indicating that ADIPOR1 could influence the milk fat metabolism through targeting some factors, little is known about the effect of ADIPOR1 on goat milk fat metabolism. To investigate the regulatory role of ADIP ...
DOI:
10.1016/j.rvsc.2021.04.001

3. Acetabular margin changes in feline hip joints – Implications for radiologic diagnosis and development of osteoarthritis

Author:
Cecilia Ley; Gabriela Ramer; Alexandra Leijon; Charles J. Ley
Source:
Research in veterinary science 2021 v.137 pp. 243-251
ISSN:
0034-5288
Subject:
cartilage; cats; computed tomography; hips; histology; humans; osteoarthritis; pathogenesis; research; veterinary medicine
Abstract:
... The development and early morphological features of feline hip osteoarthritis (OA) are largely unknown. Tears in the acetabular labrum and at the chondrolabral transition zone are suggested to be important in the pathogenesis of human hip OA, but in cats such lesions have not been described. We investigated associations between computed tomography (CT)-detected joint changes and microscopic articu ...
DOI:
10.1016/j.rvsc.2021.05.010

4. Acute myeloid leukemia: Therapy resistance and a potential role for tetraspanin membrane scaffolds

Author:
Muskan Floren; Jennifer M. Gillette
Source:
international journal of biochemistry & cell biology 2021 v.137 pp. 106029
ISSN:
1357-2725
Subject:
bone marrow; cell biology; drug resistance; drug therapy; myeloid leukemia; relapse; remission
Abstract:
... Acute myeloid leukemia (AML) is characterized by the disruption of myeloid differentiation and accumulation of blast cells in the bone marrow. While AML patients respond favorably to induction chemotherapy, long-term outcomes remain poor due to a high rate of chemoresistance. Advances with targeted therapies, which can be used in combination with conventional chemotherapy, have expanded therapeuti ...
DOI:
10.1016/j.biocel.2021.106029

5. Advances in colorectal cancer genomics and transcriptomics drive early detection and prevention

Author:
Kuen Kuen Lam; Lai Fun Thean; Peh Yean Cheah
Source:
international journal of biochemistry & cell biology 2021 v.137 pp. 106032
ISSN:
1357-2725
Subject:
biochemistry; cell biology; colorectal neoplasms; genomics; metastasis; morbidity; mortality; precision medicine; transcriptomics
Abstract:
... Colorectal carcinoma (CRC) is a high incidence cancer and leading cause of cancer mortality worldwide. The advances in genomics and transcriptomics in the past decades have improved the detection and prevention of CRC in familial CRC syndromes. Nevertheless, the ultimate goal of personalized medicine for sporadic CRC is still not within reach due no less to the difficulty in integrating population ...
DOI:
10.1016/j.biocel.2021.106032

6. Age-related expansion and increased osteoclastogenic potential of myeloid-derived suppressor cells

Author:
Zhaofei Li; Yanfang Zhao; Zhu Chen; Jannet Katz; Suzanne M. Michalek; Yuhong Li; Ping Zhang
Source:
Molecular immunology 2021 v.137 pp. 187-200
ISSN:
0161-5890
Subject:
bone marrow; bone resorption; gene expression; immunosuppression; inflammation; interleukin-6; ligands; osteoclasts; spleen
Abstract:
... Aging is associated with excessive bone loss that is not counteracted with the development of new bone. However, the mechanisms underlying age-related bone loss are not completely clear. Myeloid-derived suppressor cells (MDSCs) are a population of heterogenous immature myeloid cells with immunosuppressive functions that are known to stimulate tumor-induced bone lysis. In this study, we investigate ...
DOI:
10.1016/j.molimm.2021.07.004

7. Agricultural erosion modelling: Evaluating USLE and WEPP field-scale erosion estimates using UAV time-series data

Author:
Benjamin U. Meinen; Derek T. Robinson
Source:
Environmental modelling & software 2021 v.137 pp. 104962
ISSN:
1364-8152
Subject:
Universal Soil Loss Equation; Water Erosion Prediction Project; agricultural land; basins; computer software; soil erosion; time series analysis; unmanned aerial vehicles; watersheds
Abstract:
... Soil erosion models, typically applied at basin and watershed scales, are rarely evaluated at agricultural field scales due to the lack of spatially-distributed time series data. A novel unmanned aerial vehicle (UAV) methodology was used to quantify farm-field soil erosion from nine UAV surveys and structure-from-motion (SfM). Using a semi-distributed approach, we evaluated soil erosion estimates ...
DOI:
10.1016/j.envsoft.2021.104962

8. Alternative solvent systems for extraction and preconcentration of trace elements

Author:
María N. Oviedo; Emiliano F. Fiorentini; Mauricio Llaver; Rodolfo G. Wuilloud
Source:
Trends in analytical chemistry 2021 v.137 pp. 116227
ISSN:
0165-9936
Subject:
chemical concentration; extraction; green chemistry; ionic liquids; nanomaterials; physicochemical properties; surfactants; trace elements
Abstract:
... Alternative solvents have obtained increasing attention in the last years for sample preparation, since they can replace classical organic solvents that are considered highly toxic, volatile and flammable. The use of these solvents has contributed to develop simpler, miniaturized, inexpensive, and environmentally friendly methodologies for the determination of trace elements. Among them, ionic liq ...
DOI:
10.1016/j.trac.2021.116227

9. Analysis of 7866 feline and canine uroliths submitted between 2014 and 2020 in the Netherlands

Author:
Nikita Diante Burggraaf; Daphne Barbara Westgeest; Ronald Jan Corbee
Source:
Research in veterinary science 2021 v.137 pp. 86-93
ISSN:
0034-5288
Subject:
Cocker Spaniel; Yorkshire Terrier; bladder calculi; body condition; calcium oxalate; cats; cystine; data collection; diet history; dogs; females; magnesium ammonium phosphate; males; medical history; research; veterinary medicine; Netherlands
Abstract:
... Analysis of large datasets of uroliths is necessary to illustrate the prevalence and risk factors of urolithiasis. Furthermore, it may help to improve treatment and prevention of urolithiasis. In this study, 7866 uroliths (44.5% feline and 55.5% canine) from veterinary practitioners in the Netherlands between 2014 and 2020 were analysed. Between 2014 and 2020 the distribution over the different ty ...
DOI:
10.1016/j.rvsc.2021.04.026

10. Antilisterial effects of lysozyme-nisin combination at temperature and pH ranges optimal for lysozyme activity: Test of key findings to inactivate Listeria in raw milk

Author:
Gozde Seval Sozbilen; Ahmet Yemenicioğlu
Source:
Lebensmittel-Wissenschaft + Technologie 2021 v.137 pp. 110447
ISSN:
0023-6438
Subject:
Listeria innocua; antibacterial properties; flavor; heat; lysozyme; microorganisms; milk; odors; pH; raw milk; temperature
Abstract:
... This study aimed to determine antilisterial potential of lysozyme (LYS)-nisin (NIS) combination at temperatures and pHs optimal for LYS activity. Tests in buffers at pH 4.5 and 6.0 showed that heating at 50 or 60 °C combined with LYS-NIS caused higher Listeria innocua inactivation (- 6.2 to >6.6 log) than heating alone (- 0.05 to 5.5 log), or heating combined with LYS (- 4.34 to 6.0 log) or NIS (3 ...
DOI:
10.1016/j.lwt.2020.110447

11. Antioxidant properties of blueberry extract in different oleogel systems

Author:
Hongtu Qiu; Zhuangzhuang Qiu; Zhiyu Chen; Longlong Liu; Jiabin Wang; Hongyu Jiang; Hua Zhang; Guo-qin Liu
Source:
Lebensmittel-Wissenschaft + Technologie 2021 v.137 pp. 110364
ISSN:
0023-6438
Subject:
antioxidants; blueberries; hydrogen; nuclear magnetic resonance spectroscopy; oleogels; oxidation; peanut oil; resveratrol; soybean oil; thiobarbituric acid
Abstract:
... The oxidation properties of peanut oil and soybean oil oleogels (POO and SOO), which were used to load acid or alkaline blueberry extracts (AC or AL) and resveratrol (R), were investigated. A chemical method was employed to assess the superimposed or synergistic antioxidant activities of resveratrol. We detected functional group changes in oleogels during the course of oxidation by nuclear magneti ...
DOI:
10.1016/j.lwt.2020.110364

12. Application of nano-titanum dioxide coating on fresh Highbush blueberries shelf life stored under ambient temperature

Author:
Sami Rokayya; Fuguo Jia; Yang Li; Xin Nie; Jingwen Xu; Rui Han; Huiying Yu; Sikandar Amanullah; Manal Mused Almatrafi; Mahmoud Helal
Source:
Lebensmittel-Wissenschaft + Technologie 2021 v.137 pp. 110422
ISSN:
0023-6438
Subject:
ambient temperature; anthocyanins; ascorbic acid; chitosan; humidity; pH; sensory evaluation; shelf life; texture; titratable acidity; vegetables; weight loss
Abstract:
... Blueberries are non-climacteric fruits which have a limited shelf life due to the activities of rapid decay and softening. Coatings are eco-friendly by nature which helps in prolonging fruits and vegetable storage life. This research was carried out to determine the effects of nano-coatings on blueberries' life extension with 50–65% humidity for 8 days at ambient temperature. Different formulated ...
DOI:
10.1016/j.lwt.2020.110422

13. Beta1-integrin/Hedgehog-Gli1 signaling pathway fuels the diameter-dependent osteoblast differentiation on different TiO2 nanotubes: The optimal-diameter nanotubes for osteoblast differentiation

Author:
Yirui Xie; Xiaozhu Chen; Xuying Zheng; Ling Li; Jieyin Li; Yuling Xu; Junbing He; Yao Lin
Source:
international journal of biochemistry & cell biology 2021 v.137 pp. 106026
ISSN:
1357-2725
Subject:
biocompatible materials; bone formation; gene expression; geometry; mineralization; nanotubes; osteoblasts; signal transduction; titanium dioxide
Abstract:
... Micro/nanotextured topographies (MNTs) can modulate cell-biomaterial interactions mostly by their controllable geometrics. Among them, TiO₂ nanotubes, regarded as having a highly controllable nanoscale geometry, have been extensively investigated and applied and significantly affect diameter-dependent cell biological behaviors. In this study, we used five typical MNTs decorated with TiO₂ nanotubes ...
DOI:
10.1016/j.biocel.2021.106026

14. Caveolin-1 facilitates cell migration by upregulating nuclear receptor 4A2/retinoid X receptor α-mediated β-galactoside α2,6-sialyltransferase I expression in human hepatocarcinoma cells

Author:
Xixi Chen; Liping Wang; Xiao Yu; Shujing Wang; Jianing Zhang
Source:
international journal of biochemistry & cell biology 2021 v.137 pp. 106027
ISSN:
1357-2725
Subject:
animal models; cell adhesion; cell movement; diethylnitrosamine; fibronectins; gene expression; hepatoma; humans; metastasis; mice; phosphorylation; prognosis; promoter regions; rapamycin; sialic acid; therapeutics; transcription (genetics); transcription factors
Abstract:
... It has been reported that caveolin-1 (Cav-1) acts as a tumor promoter in hepatocellular carcinoma (HCC). Our previous studies showed that Cav-1 promoted mouse hepatocarcinoma cell adhesion to fibronectin by upregulating β-galactoside α2,6-sialyltransferase I (ST6Gal-I) expression. However, the detailed mechanism by which Cav-1 regulates ST6Gal-I is not fully understood. In this study, we found tha ...
DOI:
10.1016/j.biocel.2021.106027

15. Changes in antimicrobial activity and resistance of antibiotics in meat patties during in vitro human digestion

Author:
Seung Yun Lee; Da Young Lee; Hea Jin Kang; Ji Hyeop Kang; Sun Jin Hur
Source:
Lebensmittel-Wissenschaft + Technologie 2021 v.137 pp. 110470
ISSN:
0023-6438
Subject:
antimicrobial properties; cephalosporins; digestion; humans; meat; methicillin-resistant Staphylococcus aureus; ofloxacin; small intestine; tetracycline
Abstract:
... We aimed to determine changes in the antimicrobial activity of penicillin, cephalosporin, tetracycline, and ofloxacin present in patties cooked at 150, 200, or 250 °C, at different stages of in vitro human digestion, over Staphylococcus aureus (S. aureus) and Methicillin-resistant Staphylococcus aureus (MRSA). Results revealed that the antimicrobial activity of antibiotics were the same regardless ...
DOI:
10.1016/j.lwt.2020.110470

16. Changes of myofibrillar protein structure improved the stability and distribution of baicalein in emulsion

Author:
Jiahui Chen; Yujuan Xu; Bassey Anthony Pius; Peng Wang; Xinglian Xu
Source:
Lebensmittel-Wissenschaft + Technologie 2021 v.137 pp. 110404
ISSN:
0023-6438
Subject:
emulsions; encapsulation; hydrophobicity; protein structure; storage quality; thermal stability; ultrasonic treatment
Abstract:
... The effects of different dual frequency ultrasound treatment (DFUT) times (0, 2, 4, 6 and 8 min) on the structure of myofibrillar protein (MP) were investigated. Moreover, the effects of MP structure changes after DFUT on the stability and distribution of baicalein (BN) in emulsion were also evaluated. Results indicated that mild DFUT (≤6 min) promoted the unfolding of MP, thus increasing active s ...
DOI:
10.1016/j.lwt.2020.110404

17. Characterization and identification of a fraction from silver carp (Hypophthalmichthys molitrix) muscle hydrolysates with cryoprotective effects on yeast

Author:
Faxiang Wang; Meili Cui; Haidong Liu; Xianghong Li; Jian Yu; Yiqun Huang; Yongle Liu
Source:
Lebensmittel-Wissenschaft + Technologie 2021 v.137 pp. 110388
ISSN:
0023-6438
Subject:
Hypophthalmichthys molitrix; aspartic acid; cryoprotectants; fish; freeze-thaw cycles; gel chromatography; hydrolysis; molecular weight; muscles; peptides; proteolysis; survival rate; yeasts
Abstract:
... This study was aimed to characterize and identify a fraction from silver carp muscle hydrolysates (SCMHs) with cryoprotective effects on yeast. The SCMHs were obtained from the hydrolysis of silver carp (Hypophthalmichthys molitrix) muscle with Protamex at 50 °C for 15–240 min. The addition of SCMH generated from 30 min of proteolysis (SCMH-30) led to an increase in the yeast survival rate from 0 ...
DOI:
10.1016/j.lwt.2020.110388

18. Characterization and in vitro digestion properties of cassava starch and epigallocatechin-3-gallate (EGCG) blend

Author:
Song Zhu; Bo Liu; Fang Wang; Dejian Huang; Fang Zhong; Yue Li
Source:
Lebensmittel-Wissenschaft + Technologie 2021 v.137 pp. 110398
ISSN:
0023-6438
Subject:
X-ray diffraction; cassava starch; crystal structure; digestion; enzymatic hydrolysis; epigallocatechin gallate; hydrolysis; iodine; molecular weight; oxidation; starch; thermal stability; thermogravimetry; weight loss
Abstract:
... In this study, characteristics and in vitro digestibility of cassava starch and epigallocatechin-3-O-gallate (EGCG) blend were investigated. The structure changes of the starch during digestion were also evaluated. X-ray diffraction (XRD) and thermogravimetric analysis (TGA) revealed that starch-EGCG blend had more ordered crystal structure and stronger thermal stability as compare to the native s ...
DOI:
10.1016/j.lwt.2020.110398

19. Characterization of a potentially microcystin-producing Fischerella sp. isolated from Ajigol wetland of Iran

Author:
Bahareh Nowruzi; Adriana Sturion Lorenzi
Source:
South African journal of botany 2021 v.137 pp. 423-433
ISSN:
0254-6299
Subject:
Fischerella; area; botany; death; ecosystems; evolution; fish; genes; indigenous species; internal transcribed spacers; microcystins; research; synthesis; wetlands; Iran
Abstract:
... Ajigol wetland is a complex ecosystem in Northern Iran, which is ecologically important because contains up to 50% of threatened native plant species and aquatic organisms. Increasing of fish death and animal poisonings has led to an increased research interest and public awareness of harmful cyanobacterial blooms in this area. In the present work, we characterized a filamentous heterocyst-forming ...
DOI:
10.1016/j.sajb.2020.11.013

20. Charge substitutions at the voltage-sensing module of domain III enhance actions of site-3 and site-4 toxins on an insect sodium channel

Author:
Qing Zhu; Yuzhe Du; Yoshiko Nomura; Rong Gao; Zixuan Cang; Guo-Wei Wei; Dalia Gordon; Michael Gurevitz; James Groome; Ke Dong
Source:
Insect biochemistry and molecular biology 2021 v.137 pp. 103625
ISSN:
0965-1748
Subject:
Blattodea; Scorpiones; electric potential difference; insect biochemistry; insects; molecular biology; sodium channels; toxins
Abstract:
... Scorpion α-toxins bind at the pharmacologically-defined site-3 on the sodium channel and inhibit channel inactivation by preventing the outward movement of the voltage sensor in domain IV (IVS4), whereas scorpion β-toxins bind at site-4 on the sodium channel and enhance channel activation by trapping the voltage sensor of domain II (IIS4) in its outward position. However, limited information is av ...
DOI:
10.1016/j.ibmb.2021.103625