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1. 1H-Pteridine-2,4-dione (lumazine): a new MALDI matrix for complex (phospho)lipid mixtures analysis

Author:
Calvano, Cosima D.; Carulli, Saverio; Palmisano, Francesco
Source:
Analytical and bioanalytical chemistry 2010 v.398 no.1 pp. 499-507
ISSN:
1618-2642
Subject:
2,5-dihydroxybenzoic acid; absorption; cations; desorption; eggs; hens; ionization; mass spectrometry; milk; phosphatidylcholines; phosphatidylethanolamines; phosphatidylglycerols; phosphatidylinositols; phosphatidylserines; soymilk; sphingomyelins
Abstract:
... Nowadays, matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry represents an emerging and versatile tool for analysis of lipids. However, direct (i.e., with no previous separation of lipid classes) analysis of crude extracts containing a complex mixture of lipids (a problem typically encountered in shotgun lipidomics) is still a quite challenging task using a conven ...
DOI:
10.1007/s00216-010-3927-x
PubMed:
20593166

2. 2,5‐Dihydroxybenzoic acid solution in MALDI‐MS: ageing and use for mass calibration

Author:
Anu Teearu; Signe Vahur; Uku Haljasorg; Ivo Leito; Tõiv Haljasorg; Lauri Toom
Source:
Journal of mass spectrometry 2014 v.49 no.10 pp. 970-979
ISSN:
1076-5174
Subject:
2,5-dihydroxybenzoic acid; Fourier transform infrared spectroscopy; acetonitrile; chemical degradation; matrix-assisted laser desorption-ionization mass spectrometry; spectral analysis; spectrometers
Abstract:
... 2,5‐Dihydroxybenzoic acid (DHB) is one of the most widely used and studied matrix compounds in matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry. However, the influence of ageing of the DHB solution on the MALDI mass spectra has not been yet systematically studied. In this work, the possible changes occurring in the acidified acetonitrile/water solution of the MALDI matrix comp ...
DOI:
10.1002/jms.3395

3. 2-(2-Aminoethylamino)-5-nitropyridine as a basic matrix for negative-mode matrix-assisted laser desorption/ionization analysis of phospholipids

Author:
Lorkiewicz, Pawel; Cecilia Yappert, M.
Source:
Journal of mass spectrometry 2009 v.44 no.1 pp. 137-143
ISSN:
1076-5174
Subject:
2,5-dihydroxybenzoic acid; automation; desorption; ethanolamine; ionization; mass spectrometry; mixtures; phosphatidylcholines; phosphatidylserines; soybeans; sphingomyelins; zwitterions
Abstract:
... Fast and easy analysis of phospholipids (PLs) by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has been well demonstrated. However, when using common organic matrices, such as 2,5-dihydroxybenzoic acid (DHB), the detection of most PL classes in positive-ion mode is difficult when PLs containing zwitterionic groups, such as phosphatidylcholines (PCs) and sphingomyelins (S ...
DOI:
10.1002/jms.1483

4. 2-Phenyl-3-(p-aminophenyl) Acrylonitrile: A Reactive Matrix for Sensitive and Selective Analysis of Glycans by MALDI-MS

Author:
Ling Ling; Chunsheng Xiao; Yao Ma; Liyan Jiang; Sheng Wang; Liming Guo; Shimei Jiang; Xinhua Guo
Source:
Analytical chemistry 2019 v.91 no.14 pp. 8801-8807
ISSN:
1520-6882
Subject:
2,5-dihydroxybenzoic acid; aldehydes; analytical specificity; blood serum; desorption; detection limit; glycoproteins; humans; ionization; matrix-assisted laser desorption-ionization mass spectrometry; nitriles; peptides; polysaccharides; tandem mass spectrometry
Abstract:
... Analysis of glycans by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is usually limited by the intrinsically low abundance and low ionization efficiency of glycans. Aiming to enhance the ionization efficiency of glycans and simplify the sample preparation procedure during MALDI-MS analysis, we reported herein a novel reactive matrix, 2-phenyl-3-(p-aminophenyl) acrylonitr ...
DOI:
10.1021/acs.analchem.9b01434

5. 3,4-Dimethoxycinnamic Acid as a Novel Matrix for Enhanced In Situ Detection and Imaging of Low-Molecular-Weight Compounds in Biological Tissues by MALDI-MSI

Author:
Huixin He; Liang Qin; Yawen Zhang; Manman Han; Jinming Li; Yaqin Liu; Kaidi Qiu; Xiaoyan Dai; Yanyan Li; Maomao Zeng; Huihong Guo; Yijun Zhou; Xiaodong Wang
Source:
Analytical chemistry 2019 v.91 no.4 pp. 2634-2643
ISSN:
1520-6882
Subject:
2,5-dihydroxybenzoic acid; absorption; alkaloids; brain; desorption; flavonoids; graphene oxide; image analysis; ionization; lipids; liquid chromatography; liver; metabolites; nanosilver; oligopeptides; plant tissues; rats; seeds; tandem mass spectrometry
Abstract:
... Low-molecular-weight (low-MW) compounds have many essential functions in biological processes, and the molecular imaging of as many low-MW compounds as possible is critical for understanding complex biological processes. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is an emerging molecular-imaging technology that enables determination of the spatial distributio ...
DOI:
10.1021/acs.analchem.8b03522

6. 3-Aminophthalhydrazide (Luminol) As a Matrix for Dual-Polarity MALDI MS Imaging

Author:
Bin Li; Ruiyang Sun; Andrew Gordon; Junyue Ge; Ying Zhang; Ping Li; Hua Yang
Source:
Analytical chemistry 2019 v.91 no.13 pp. 8221-8228
ISSN:
1520-6882
Subject:
2,5-dihydroxybenzoic acid; absorption; biochemical pathways; biomarkers; brain; central nervous system diseases; desorption; fatty acids; image analysis; ionization; matrix-assisted laser desorption-ionization mass spectrometry; metabolites; mice; nucleotides; sodium; sphingolipids
Abstract:
... In many aspects of the matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) technique, the discovery of new MALDI matrixes has been a major task for the improvement of ionization efficiency, signal intensity, and molecular coverage. In this work, five analog compounds, including phthalhydrazide, 3-aminophthalhydrazide (3-APH or luminol) and its sodium salt, 4-aminophth ...
DOI:
10.1021/acs.analchem.9b00803

7. 3-Aminoquinoline/p-Coumaric Acid as a MALDI Matrix for Glycopeptides, Carbohydrates, and Phosphopeptides

Author:
Fukuyama Yuko; Funakoshi Natsumi; Takeyama Kohei; Hioki Yusaku; Nishikaze Takashi; Kaneshiro Kaoru; Kawabata Shin-ichirou; Iwamoto Shinichi; Tanaka Koichi
Source:
Analytical chemistry 2014 v.86 no.4 pp. 1937-1942
ISSN:
1520-6882
Subject:
sialic acids; sulfates; glycosylation; biomarkers; 2,5-dihydroxybenzoic acid; dissociation; p-coumaric acid; phosphates; phosphorylation; mass spectrometry; glycopeptides
Abstract:
... Glycosylation and phosphorylation are important post-translational modifications in biological processes and biomarker research. The difficulty in analyzing these modifications is mainly their low abundance and dissociation of labile regions such as sialic acids or phosphate groups. One solution in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry is to improve matrices for gly ...
DOI:
10.1021/ac4037087

8. 4‐Chloro‐α‐cyanocinnamic acid is an efficient soft matrix for cyanocobalamin detection in foodstuffs by matrix‐assisted laser desorption/ionization mass spectrometry (MALDI MS)

Author:
Cosima Damiana Calvano; Giovanni Ventura; Francesco Palmisano; Tommaso R.I. Cataldi
Source:
Journal of mass spectrometry 2016 v.51 no.9 pp. 841-848
ISSN:
1076-5174
Subject:
2,5-dihydroxybenzoic acid; chemical bonding; desorption; egg yolk; energy; fish; hens; ionization; ions; ligands; liver; mass spectrometry; meat; nitroanilines; qualitative analysis; sodium; vitamin B12
Abstract:
... 4‐Chloro‐α‐cyanocinnamic acid (ClCCA) is a very useful matrix able to give the protonated adduct [M+H]⁺ of intact cyanocobalamin (CNCbl) as the base peak (m/z 1355.58) in matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry (MS). The only fragment observed is [M‐CN + H]⁺• formed through the facile •CN neutral loss reflecting the fairly low Co–C bond energy. All other investigated ...
DOI:
10.1002/jms.3817

9. Absorption, Metabolism and Excretion of Cranberry (Poly)phenols in Humans: A Dose Response Study and Assessment of Inter-Individual Variability

Author:
Rodrigo P. Feliciano; Charlotte E. Mills; Geoffrey Istas; Christian Heiss; Ana Rodriguez-Mateos
Source:
Nutrients 2017 v.9 no.3 pp. -
ISSN:
2072-6643
Subject:
2,5-dihydroxybenzoic acid; benzaldehyde; blood; caffeic acid; cinnamic acid; cranberries; dose response; excretion; ferulic acid; flavonols; fruit juices; health effects assessments; humans; intestinal absorption; intestinal microorganisms; lactones; men; metabolism; metabolites; polyphenols; randomized clinical trials; sinapic acid; syringic acid; urine
Abstract:
... The beneficial health effects of cranberries have been attributed to their (poly)phenol content. Recent studies have investigated the absorption, metabolism and excretion of cranberry (poly)phenols; however, little is known about whether they follow a dose response in vivo at different levels of intake. An acute double-blind randomized controlled trial in 10 healthy men with cranberry juices conta ...
DOI:
10.3390/nu9030268
PubMed:
28287476
PubMed Central:
PMC5372931

10. Accumulation of Polyphenolic Compounds and Osmolytes under Dehydration Stress and Their Implication in Redox Regulation in Four Indigenous Aromatic Rice Cultivars

Author:
Nivedita Dey; Soumen Bhattacharjee
Source:
Rice science 2020 v.27 no.4 pp. 329-344
ISSN:
1672-6308
Subject:
2,5-dihydroxybenzoic acid; Oryza sativa; apigenin; benzoic acid; betaine; biomarkers; caffeic acid; catechin; chlorogenic acid; confocal microscopy; cultivars; drought tolerance; gallic acid; homeostasis; hydrogen peroxide; indigenous species; kaempferol; myricetin; naringin; oxidation; p-coumaric acid; polyethylene glycol; polyphenols; potassium; proline; protocatechuic acid; quercetin; rice; rutin; salicylic acid; seeds; sinapic acid; superoxide anion; syringic acid; thiobarbituric acid-reactive substances; thiols; water stress; India
Abstract:
... Present work was undertaken to screen some drought tolerant indigenous aromatic rice cultivars (IARCs), commonly cultivated in West Bengal, India, based on their capacity to produce osmolytes, redox-sensitive phenolic acids and flavonoids, as contrivances for redox-regulation under drought stress. Polyethylene glycol induced post imbibitional dehydration stress mediated changes in redox regulatory ...
DOI:
10.1016/j.rsci.2020.05.008

11. Alkali-hydroxide-doped matrices for structural characterization of neutral underivatized oligosaccharides by MALDI time-of-flight mass spectrometry

Author:
Tzeng, Yan-Kai; Zhu, Zhiqiang; Chang, Huan-Cheng
Source:
Journal of mass spectrometry 2009 v.44 no.3 pp. 375-383
ISSN:
1076-5174
Subject:
2,5-dihydroxybenzoic acid; aqueous solutions; beta-cyclodextrin; derivatization; desorption; dextran; hexoses; ionization; ions; isomers; lithium; mass spectrometry; mixing; oligosaccharides; sodium hydroxide
Abstract:
... We report new approaches using alkali-hydroxide-doped matrices to facilitate structural characterization of neutral underivatized oligosaccharides by matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) MS. The approaches involved pretreatment of the analytes with NaOH or LiOH in aqueous solution, followed by mixing them with MALDI matrices prior to MS analysis. It was found th ...
DOI:
10.1002/jms.1515

12. Alkylated Dihydroxybenzoic Acid as a MALDI Matrix Additive for Hydrophobic Peptide Analysis

Author:
Fukuyama Yuko; Tanimura Ritsuko; Maeda Kazuki; Watanabe Makoto; Kawabata Shin-Ichirou; Iwamoto Shinichi; Izumi Shunsuke; Tanaka Koichi
Source:
Analytical chemistry 2012 v.84 no.9 pp. 4237-4243
ISSN:
1520-6882
Subject:
2,5-dihydroxybenzoic acid; desorption; hydrophilicity; hydrophobicity; image analysis; ionization; mass spectrometry; peptides; phosphorylase
Abstract:
... Hydrophobic peptides are generally difficult to detect using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) because the majority of MALDI matrixes are hydrophilic and therefore have a low affinity for hydrophobic peptides. Here, we report on a novel matrix additive, o-alkylated dihydroxybenzoic acid (ADHB), which is a 2,5-dihydroxybenzoic acid (DHB) derivative incorporati ...
DOI:
10.1021/ac300540r

13. Alleviative effects of litchi (Litchi chinensis Sonn.) flower on lipid peroxidation and protein degradation in emulsified pork meatballs

Author:
Yi Ding; Sheng-Yao Wang; Deng-Jye Yang; Ming-Hsu Chang; Yi-Chen Chen
Source:
Yàowù shípǐn fēnxī 2015 v.23 no.3 pp. 501-508
ISSN:
1021-9498
Subject:
2,5-dihydroxybenzoic acid; Litchi chinensis; additives; antioxidants; centrifugation; cooked foods; drugs; epicatechin; flowers; frozen storage; hydroquinone; lipid peroxidation; lipids; oxidation; physicochemical properties; pork; powders; protein degradation; sensory evaluation; storage time; texture; thiobarbituric acid-reactive substances; thiols; water holding capacity
Abstract:
... To avoid or retard the lipid peroxidation of meat products, antioxidants are commonly added. Considering the safety and health of additives in meat products, consumers prefer natural antioxidants rather than synthetic ones. Gentisic acid and epicatechin were identified as the major phenolic acid and flavonoid, respectively, of litchi flowers (LFs). The physicochemical properties of pork meatballs ...
DOI:
10.1016/j.jfda.2015.02.004

14. Amine-Functionalized Sol–Gel-Based Lab-in-a-Pipet-Tip Approach for the Fast Enrichment and Specific Purification of Phosphopeptides in MALDI-MS Applications

Author:
Atakay Mehmet; Çelikbıçak Ömür; Salih Bekir
Source:
Analytical chemistry 2012 v.84 no.6 pp. 2713-2720
ISSN:
1520-6882
Subject:
2,5-dihydroxybenzoic acid; beta-casein; bovine serum albumin; detection limit; glass fibers; pH; peptides; phosphopyruvate hydratase; phosphoric acid; purification methods; skim milk
Abstract:
... Amine-functionalized sol–gels were investigated for the enrichment and purification of phosphopeptides from digested protein mixture solutions. Tetramethylorthosilicate (TMOS) and N′[3-(trimethoxysilyl)-propyl]-diethylenetriamine (TPDA) were used in a 1:1 mole ratio in the production of amine-functionalized sol–gels. The sol–gel network was then used for phosphopeptide enrichment. Phosphopeptide e ...
DOI:
10.1021/ac203008u

15. Ammonium Sulfate Improves Detection of Hydrophilic Quaternary Ammonium Compounds through Decreased Ion Suppression in Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Author:
Sugiyama Eiji; Masaki Noritaka; Matsushita Shoko; Setou Mitsutoshi
Source:
Analytical chemistry 2015 v.87 no.22 pp. 11176-11181
ISSN:
1520-6882
Subject:
2,5-dihydroxybenzoic acid; ammonium sulfate; bioactive properties; brain; carnitine; choline; derivatization; desorption; hydrophilicity; image analysis; ionization; matrix-assisted laser desorption-ionization mass spectrometry; phosphatidylcholines; potassium
Abstract:
... Hydrophilic quaternary ammonium compounds (QACs) include derivatives of carnitine (Car) or choline, which are known to have essential bioactivities. Here we developed a technique for improving the detection of hydrophilic QACs using ammonium sulfate (AS) in matrix-assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS). In MALDI mass spectrometry for brain homogenates, the addit ...
DOI:
10.1021/acs.analchem.5b02672

16. Analysis of Initial Reactions of MALDI Based on Chemical Properties of Matrixes and Excitation Condition

Author:
Lai Yin-Hung; Wang Chia-Chen; Chen Chiu Wen; Liu Bo-Hong; Lin Sheng Hsien; Lee Yuan Tseh; Wang Yi-Sheng
Source:
Journal of physical chemistry 2012 v.116 no.32 pp. 9635-9643
ISSN:
1520-5207
Subject:
2,5-dihydroxybenzoic acid; absorption; desorption; energy; fluorescence; ionization; ions; photons; physicochemical properties; wavelengths
Abstract:
... This investigation concerns the initial chemical reactions that affect the ionization of matrixes in matrix-assisted laser desorption/ionization (MALDI). The study focuses on the relaxations of photon energy that occur on a comparable time scale to that of ionization, in which the available laser energy is shared and the ionization condition is changed. The relaxations include fluorescence, fragme ...
DOI:
10.1021/jp304709q

17. Analysis of phytochemical composition of leaf extract of sacred fig (Ficus religiosa L.) by UPLC-QqQ-MS and assessment of their hepatocurative potential in mouse model

Author:
Udhayaraj Suriyakalaa; Devanesan Arul Ananth; Rajamanickam Ramachandran; Devaraj Sankarganesh; Jayaraman Angayarkanni; Zipora Tietel; Shanmugam Achiraman
Source:
South African journal of botany 2022 pp. -
ISSN:
0254-6299
Subject:
2,5-dihydroxybenzoic acid; Ficus religiosa; antioxidant activity; bilirubin; carbon tetrachloride; catechin; chemical constituents of plants; creatinine; ethnobotany; figs; hepatotoxicity; histopathology; leaf extracts; leaves; liver; mass spectrometry; mice; polyphenols; protocatechuic acid; quinic acid; rutin; ultra-performance liquid chromatography; urea
Abstract:
... In view of their remarkable pharmacological properties and bioactivities Ficus sp. are used in traditional medicines. Ficus religiosa is richly endowed with ethnobotanical values and it is a promising entity in various medicinal formulations; however, comprehensive phytochemical identification and quantification of F. religiosa using Ultra Performance Liquid Chromatography Triple Quadrupole Mass S ...
DOI:
10.1016/j.sajb.2022.01.007

18. Analyte-Size-Dependent Ionization and Quantification of Monosaccharides in Human Plasma Using Cation-Exchanged Smectite Layers

Author:
Ding Yuqi; Kawakita Kento; Xu Jiawei; Akiyama Kazuhiko; Fujino Tatsuya
Source:
Analytical chemistry 2015 v.87 no.15 pp. 7944-7950
ISSN:
1520-6882
Subject:
2,5-dihydroxybenzoic acid; desorption; humans; ionization; mass spectrometry; molecular weight; monosaccharides; polymers; quantitative analysis; smectite
Abstract:
... Smectite, a synthetic inorganic polymer with a saponite structure, was subjected to matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). Typical organic matrix molecules 2,4,6-trihydroxyacetophenone (THAP) and 2,5-dihydroxybenzoic acid (DHBA) were intercalated into the layer spacing of cation-exchanged smectite, and the complex was used as a new matrix for laser desorption/ion ...
DOI:
10.1021/acs.analchem.5b01770

19. Analytical Methods Applied to Assess Chemical Composition, Nutritional Value and In Vitro Bioactivities of Terfezia olbiensis and Terfezia claveryi from Turkey

Author:
İbrahim Kıvrak
Source:
Food analytical methods 2015 v.8 no.5 pp. 1279-1293
ISSN:
1936-9751
Subject:
2,5-dihydroxybenzoic acid; Terfezia; analytical methods; benzoic acid; beta-carotene; bioactive properties; bleaching; decolorization; dietary supplements; enzymes; essential amino acids; ethyl acetate; food additives; free amino acids; free radical scavengers; free radicals; fructose; heavy metals; hexane; industry; ingredients; lipid peroxidation; mannitol; minerals; mushrooms; nutritive value; protocatechuic acid; rhamnose; shelf life; trehalose; truffles
Abstract:
... In this study, nutritional value, free amino acids, phenolic and sugar compounds, mineral and heavy metal contents of truffles, Terfezia olbiensis, and Terfezia claveryi from Turkey were chemically characterized using different analytical methods. In vitro antioxidant characteristics, β-carotene bleaching assay, 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, ABTS cation ra ...
DOI:
10.1007/s12161-014-0009-2

20. Analytical determination and pharmacokinetics of major metabolites of carbasalate calcium in broilers following oral administration

Author:
WANG, X.; HUANG, L.-L.; CHEN, D.-M.; IHSAN, A.; YUAN, Z.-H.
Source:
Journal of veterinary pharmacology and therapeutics 2011 v.34 no.4 pp. 410-416
ISSN:
0140-7783
Subject:
2,5-dihydroxybenzoic acid; anti-inflammatory agents; aspirin; body weight; calcium; metabolites; oral administration; pharmacokinetics; salicylic acid
Abstract:
... Wang, X., Huang, L.-L., Chen, D.-M., Ihsan, A., Yuan, Z.-H. Analytical determination and pharmacokinetics of major metabolites of carbasalate calcium in broilers following oral administration. J. vet. Pharmacol. Therap.34, 410-416. As a newer anti-inflammatory agent, carbasalate calcium is used in various animal species. In this study, the pharmacokinetics of carbasalate calcium was investigated i ...
DOI:
10.1111/j.1365-2885.2010.01250.x
PubMed:
21091728

21. Anthelmintic activity of phenolic acids from the axlewood tree Anogeissus leiocarpus on the filarial nematode Onchocerca ochengi and drug-resistant strains of the free-living nematode Caenorhabditis elegans

Author:
D. Ndjonka; E.D. Abladam; B. Djafsia; I. Ajonina-Ekoti; M.D. Achukwi; E. Liebau
Source:
Journal of helminthology 2014 v.88 no.4 pp. 481-488
ISSN:
1475-2697
Subject:
2,5-dihydroxybenzoic acid; Anogeissus leiocarpa; Caenorhabditis elegans; Onchocerca ochengi; adults; albendazole; drug resistance; drugs; ellagic acid; free-living nematodes; gallic acid; ivermectin; lethal concentration 50; levamisole; microfilariae; models; nematode infections; parasites; phenols; toxicity; trees
Abstract:
... The effect of three phenols (ellagic, gentisic and gallic acids) from the axlewood tree Anogeissus leiocarpus on Onchocerca ochengi and drug-resistant strains of Caenorhabditis elegans, a model organism for research on nematode parasites, is investigated. Worms were incubated in different concentrations of phenols and their survival was monitored after 48 h. Among the three acids, ellagic acid str ...
DOI:
10.1017/S0022149X1300045X
PubMed:
23768773

22. Anti-apoptotic effects of novel phenolic antioxidant isolated from the Pacific oyster (Crassostrea gigas) on cultured human hepatocytes under oxidative stress

Author:
Hirotoshi Fuda; Mitsugu Watanabe; Shu-Ping Hui; Sae Joko; Hiroaki Okabe; Shigeki Jin; Seiji Takeda; Emiko Miki; Takayuki Watanabe; Hitoshi Chiba
Source:
Food chemistry 2015 v.176 pp. 226-233
ISSN:
0308-8146
Subject:
2,5-dihydroxybenzoic acid; Crassostrea gigas; DNA; antioxidants; apoptosis; ascorbic acid; butylated hydroxytoluene; catechin; cell viability; chlorogenic acid; cytotoxicity; daidzein; docosahexaenoic acid; eicosapentaenoic acid; flow cytometry; hepatocytes; hepatoprotective effect; humans; mass spectrometry; matairesinol; necrosis; oxidative stress; oyster meat; oysters; polyphenols
Abstract:
... The antioxidant, and hepatoprotective properties of 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA), a natural phenolic antioxidant isolated from the Pacific oyster, were defined using cultured human hepatocyte-derived cells (C3A). DHMBA showed no cytotoxicity at 62.5–500μM, as well as chlorogenic acid (CGA), vitamin C, and vitamin E. However, butylated hydroxytoluene, eicosapentaenoic acid, docosah ...
DOI:
10.1016/j.foodchem.2014.12.066

23. Anti-inflammatory glycosides isolated from the aerial parts of Morinda parvifolia

Author:
Xianming Su; Jian Zhang; Fenghua Li; Changkang Li; Jia Fu; Baoming Li; Ruoyun Chen; Jie Kang
Source:
Phytochemistry letters 2019 v.33 pp. 55-60
ISSN:
1874-3900
Subject:
2,5-dihydroxybenzoic acid; Croton; Morinda; aerial parts; anti-inflammatory activity; benzoic acid; ears; edema; ethyl acetate; gene expression; glycosides; herbal medicines; indigestion; inhibitory concentration 50; interleukin-6; mice; oils; spectral analysis; tracheitis
Abstract:
... The plant Morinda parvifolia is traditionally used as an herbal medicine for the treatment of dyspepsia, tracheitis, and coughing. The ethyl acetate extract of the aerial parts of M. parvifolia showed significant inhibition against ear edema in mice induced by croton oil (36.4% inhibition). Four undescribed glycosides, 2-hydroxymethyl anthraquinone-3-O-β-primeveroside, p-hydroxy benzoic acid 4-O-β ...
DOI:
10.1016/j.phytol.2019.07.008

24. Anti-influenza mechanism of phenolic phytochemicals from Canarium album (Lour.) DC. leaf extract

Author:
Mengjie Xiao; Bobby Lim-Ho Kong; Yahui Zhang; Yinhua Yang; Jiaqi Lu; Hung-Kay Lee; Fei Cao; Pang-Chui Shaw
Source:
Journal of ethnopharmacology 2022 v.292 pp. 115175
ISSN:
0378-8741
Subject:
2,5-dihydroxybenzoic acid; Canarium album; Influenza A virus; circular dichroism spectroscopy; flavonoids; glycosides; heat; hemagglutination; hemagglutinins; influenza; leaf extracts; leaves; lungs; moieties; phenotype; probability; reverse genetics; sialidase; toxic substances; traditional medicine; viruses
Abstract:
... Canarium album (Lour.) DC. belongs to the Burseraceae family. Its leaf, named as Ganlanye (GLY), was recorded to treat warm disease symptoms via clearing lung heat and toxicants in medical classics. Its aqueous extract had anti-influenza activity in our previous phenotypic screening. However, its active components and mechanism were not identified. We aim to isolate the anti-influenza phytochemica ...
DOI:
10.1016/j.jep.2022.115175

25. Anticholinesterase Activity of Phenolic Acids and their Derivatives

Author:
Dominik Szwajgier
Source:
Zeitschrift für Naturforschung 2014 v.68 no.3-4 pp. 125-132
ISSN:
1865-7125
Subject:
2,5-dihydroxybenzoic acid; acetylcholine; caftaric acid; cholinesterase; esters; molecular weight; nordihydroguaiaretic acid; rosmarinic acid
Abstract:
... The ability of 36 phenolic acids and their derivatives to inhibit acetyl- and butyrylcholinesterase was studied. The most efficient acetylcholine inhibitors were: carnosic acid = gentisic acid > 3-hydroxy-4-methoxycinnamic acid = ethyl ferulate = ethyl vanillate = nordihydroguaiaretic acid > ethyl 4-hydroxybenzoate = methyl ferulate. The order of effectiveness towards butyrylcholinesterase was: ca ...
DOI:
10.1515/znc-2013-3-408

26. Antimicrobial activity of ozone. Effectiveness against the main wine spoilage microorganisms and evaluation of impact on simple phenols in wine

Author:
R. Guzzon; T. Nardin; O. Micheletti; G. Nicolini; R. Larcher
Source:
Australian journal of grape and wine research 2013 v.19 no.2 pp. 180-188
ISSN:
1322-7130
Subject:
2,5-dihydroxybenzoic acid; antimicrobial properties; ethanol; fermentation; microbial contamination; microorganisms; oak barrels; oak chips; organic matter; ozone; phenols; spoilage; wine industry; wines; wood
Abstract:
... BACKGROUND AND AIMS: Microbial contamination affects winemaking, especially after fermentation, e.g. wine ageing in barrels or in contact with oak pieces, when spoilage microbes find an environment favourable for their development. Ozone was evaluated as a sanitising agent in order to assess its potential to prevent microbial spoilage occurring during ageing of wine in barrels using a model system ...
DOI:
10.1111/ajgw.12018

27. Antioxidant activities, total phenolics and HPLC analyses of the phenolic compounds of extracts from common Mediterranean plants

Author:
Taha M. Rababah; Khalil I. Ereifej; Ranya B. Esoh; Muhammad H. Al-u'datt; Mohammad A. Alrababah; W. Yang
Source:
Natural product research 2011 v.25 no.6 pp. 596-605
ISSN:
1478-6427
Subject:
2,2-diphenyl-1-picrylhydrazyl; 2,5-dihydroxybenzoic acid; Petroselinum crispum; Salvia officinalis; antioxidant activity; antioxidants; benzoic acid; caffeic acid; catechin; chlorogenic acid; correlation; epicatechin; gallic acid; high performance liquid chromatography; parsley; plant extracts; protocatechuic acid; sage; syringic acid; vanillic acid; Jordan
Abstract:
... In this study, the total phenolic amounts and antioxidant activities of plant extracts obtained from some common Mediterranean plant species collected from different places in Jordan were determined. The phenolic constituents of these extracts were also determined using HPLC. The total phenolic amounts ranged from 52.8 to 876.9 mg GAE per 100 g dry material. The antioxidant activities were evaluat ...
DOI:
10.1080/14786419.2010.488232

28. Antioxidant activity and chemical difference in fruit of different Actinidia sp.

Author:
Piotr Latocha; Tomasz Krupa; Rafał Wołosiak; Elwira Worobiej; Jacek Wilczak
Source:
International journal of food sciences and nutrition 2010 v.61 no.4 pp. 381-394
ISSN:
1465-3478
Subject:
2,5-dihydroxybenzoic acid; Actinidia arguta; Actinidia deliciosa; Actinidia kolomikta; Actinidia melanandra; antioxidant activity; ascorbic acid; carotenoids; chlorophyll; flavonoids; fruits; high performance liquid chromatography; nutrition; tannins
Abstract:
... The present research aimed at evaluating the vitamin C, total phenolic content (TPC), phenolic compounds, carotenoids, and chlorophyll contents, as well as antioxidant activity (AAC) of six Actinidia species fruit. Vitamin C, phenolic compounds, carotenoids and chlorophylls were measured using high-performance liquid chromatography. TPC was determined using the Folin–Ciocalteau reagent, and AAC us ...
DOI:
10.3109/09637480903517788

29. Antioxidant and Anti‐inflammatory Activities of Methanol Extracts of Tremella fuciformis and Its Major Phenolic Acids

Author:
Hua Li; Hee‐Seok Lee; Su‐Hwan Kim; BoKyung Moon; Chan Lee
Source:
Journal of food science 2014 v.79 no.4 pp. C460
ISSN:
0022-1147
Subject:
2,5-dihydroxybenzoic acid; Tremella fuciformis; antioxidant activity; chloroform; free radical scavengers; low density lipoprotein; methanol; mushrooms; nitric oxide; nitric oxide synthase; oxidation
Abstract:
... Methanol extract subfractions of the edible white jelly mushroom (Tremella fuciformis), were assessed for the following antioxidant properties: ABTS⁺ radical scavenging activity, 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging activity, and inhibitory activity of human low‐density lipoprotein (LDL) oxidation. Among the subfractions tested, the chloroform subfraction exhibited the strongest ...
DOI:
10.1111/1750-3841.12393
PubMed:
24547933

30. Antioxidant capacity and interaction of endogenous phenolic compounds from tea seed oil

Author:
Guoyan Liu; Wenqi Zhu; Sitong Li; Wanli Zhou; Huijuan Zhang; Jing Wang; Xiaofang Liu; Jixian Zhang; Li Liang; Xin Xu
Source:
Food chemistry 2022 v.376 pp. 131940
ISSN:
0308-8146
Subject:
2,5-dihydroxybenzoic acid; antioxidant activity; antioxidants; ethanol; food chemistry; lipid peroxidation; oxidative stability; quercetin; rancidity; seed oils; tartaric acid
Abstract:
... Endogenous phenols play a significant role in delaying oil rancidity. In this study, the profile of 22 endogenous phenols was determined from tea seed oil by UPLC-MS/MS, of which 15 phenols were identified for the first time. Then seven phenols with high content and strong antioxidant capacity were selected to investigate interaction using the DPPH· and Rancimat. It was found that the interaction ...
DOI:
10.1016/j.foodchem.2021.131940

31. Antioxidative Effects of Phenolic Compounds of Mushroom Mycelia in Simulated Regions of the Human Colon, In Vitro Study

Author:
Emanuel Vamanu; Diana Pelinescu; Ionela Avram
Source:
Polish journal of food and nutrition sciences 2017 v.68 no.1 pp. 83-90
ISSN:
2083-6007
Subject:
2,5-dihydroxybenzoic acid; Agaricus bisporus; Bifidobacterium; Enterobacteriaceae; Lactobacillus; Lentinula edodes; Pleurotus ostreatus; antioxidant activity; antioxidants; basidia; bioactive compounds; caffeic acid; colon; fermentation; freeze drying; high performance liquid chromatography; humans; metabolites; mushrooms; mycelium; polyphenols
Abstract:
... Many compounds in mushrooms are biologically active; however, the in vivo actions of their metabolites are poorly understood. An in vitro system, GIS1, was used to simulate the fermentation action of microbiota in each colon region. We used MycoPo, a natural product obtained from the lyophilized mycelia of different Pleurotus ostreatus species to determine the biological effects in human-colon reg ...
DOI:
10.1515/pjfns-2017-0010

32. Antioxidative and anti-inflammatory effects of polyphenol-rich litchi (Litchi chinensis Sonn.)-flower-water-extract on livers of high-fat-diet fed hamsters

Author:
Yuan-Yen Chang; Deng-Jye Yang; Chih-Hsien Chiu; Yi-Ling Lin; Jr-Wei Chen; Yi-Chen Chen
Source:
Journal of functional foods 2013 v.5 no.1 pp. 44-52
ISSN:
1756-4646
Subject:
2,5-dihydroxybenzoic acid; Litchi chinensis; anti-inflammatory activity; antioxidant activity; blood lipids; drinking; epicatechin; hamsters; high fat diet; histopathology; liver; protective effect; thiobarbituric acid-reactive substances
Abstract:
... Gentisic acid and epicatechin are two major compounds in phenolic acids and flavonoids of litchi-flower-water extracts (LFWEs), respectively. Increased (p<0.05) serum lipids and liver size/lipid, damage/inflammatory indices, TBARS value, CRP level, MMP-9 activity, and decreased (p<0.05) liver GSH and TEAC levels, and SOD, CAT and GSH-Px activities were observed in high-fat-diet fed hamsters compar ...
DOI:
10.1016/j.jff.2012.08.002

33. Application of dyes as doping agents in MALDI-MS matrices for the signal enhancement of proteins

Author:
Arslan Ali; Najia Shahid; Syed Ghulam Musharraf
Source:
RSC advances 2017 v.7 no.11 pp. 6598-6604
ISSN:
2046-2069
Subject:
2,5-dihydroxybenzoic acid; bovine serum albumin; casein; egg albumen; erythrosine; honey; insulin; myoglobin; peptides; sinapic acid
Abstract:
... Matrix Assisted Laser Desorption Ionization Mass Spectrometry (MALDI-MS) is considered as a technique of choice for analysing proteins and peptides. Several modifications have been proposed to increase the sensitivity of MALDI-MS procedure so that low abundant proteins can be targeted. The present work describes the study of the possible increase in MALDI-MS sensitivity by increasing the ion gener ...
DOI:
10.1039/c6ra27156a

34. Application of ionic liquid matrices in spectral analysis of poly(lactide) - solid state NMR spectroscopy versus matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry

Author:
Beata Miksa; Marek Sochacki; Jan Libiszowski; Andrzej Duda; Wlodzimierz Ciesielski; Marek J. Potrzebowski
Source:
Analytical methods 2012 v.4 no.2 pp. 377-383
ISSN:
1759-9679
Subject:
2,5-dihydroxybenzoic acid; amines; benzoic acid; carbon; desorption; droplets; indole acetic acid; ionic liquids; isomerization; liquids; matrix-assisted laser desorption-ionization mass spectrometry; melting; nuclear magnetic resonance spectroscopy; polylactic acid; signal-to-noise ratio; spectral analysis; stable isotopes; temperature; thermal stability
Abstract:
... The work presented here shows the complementarity of Solid State NMR (SS NMR) spectroscopy and Matrix-Assisted Laser Desorption/Ionization-time-of-flight (MALDI-TOF) mass spectrometry in spectral analysis of poly(l-lactide) (PLLA) using second-generation ionic liquid matrices (ILM II) prepared from N,N-diisopropylethylamine (DEA) and DHB (2,5-dihydroxybenzoic acid), IAA (3-indoleacrylic acid), and ...
DOI:
10.1039/c2ay05332b

35. Application of the van’t Hoff dependences in the characterization of molecularly imprinted polymers for some phenolic acids

Author:
Natalia Denderz; Jozef Lehotay
Source:
Journal of chromatography 2012 v.1268 no. pp. 44-52
ISSN:
0021-9673
Subject:
2,5-dihydroxybenzoic acid; 4-hydroxybenzoic acid; Fourier transform infrared spectroscopy; acetonitrile; acrylamides; gallic acid; high performance liquid chromatography; methanol; molecular imprinting; polymers; protocatechuic acid; quercetin; reflectance; scanning electron microscopy; sorption; syringic acid; temperature; thermodynamics; vanillic acid
Abstract:
... Thermodynamic analysis was used to quantify the contribution of entropic and enthalpic terms of the binding processes of selected phenolic acids (PAs), quercetin and diperodon on series of molecularly imprinted polymers (MIPs). All polymers were prepared using acrylamide as functional monomer and acetonitrile as a porogen. The following PAs were used as templates – gallic (GA), gentisic (GeA), syr ...
DOI:
10.1016/j.chroma.2012.10.025

36. Assessing Anticancer Potential of Blueberry Flavonoids, Quercetin, Kaempferol, and Gentisic Acid, Through Oxidative Stress and Apoptosis Parameters on HCT-116 Cells

Author:
Ebru Demirel Sezer; Latife Merve Oktay; Elif Karadadaş; Hikmet Memmedov; Nur Selvi Gunel; Eser Sözmen
Source:
Journal of medicinal food 2019 v.22 no.11 pp. 1118-1126
ISSN:
1557-7600
Subject:
2,5-dihydroxybenzoic acid; Vaccinium myrtillus; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; blueberries; cytotoxicity; diet; flow cytometry; fruit extracts; kaempferol; liquid chromatography; neoplasms; oxidants; oxidative stress; polyphenols; protein composition; protein microarrays; proteins; quercetin; tandem mass spectrometry; therapeutics
Abstract:
... In recent years, natural products gained popularity with their anti-inflammatory and antioxidant effects mediated by chemical compounds within their composition. Study results offering them as palliative therapy options in cancer or as anticancer agents with high levels of cytotoxicity brought a new approach to combine cancer treatment protocols with these products. From a different perspective, e ...
DOI:
10.1089/jmf.2019.0098

37. Assessment of morphological and phytochemical attributes in triploid and hexaploid plants of the bioenergy crop Miscanthus×giganteus

Author:
Bimal Kumar Ghimire; Eun Soo Seong; Truong Xuan Nguyen; Ji Hye Yoo; Chang Yeon Yu; Seung Hyun Kim; Ill-Min Chung
Source:
Industrial crops and products 2016 v.89 pp. 231-243
ISSN:
0926-6690
Subject:
2,5-dihydroxybenzoic acid; C4 plants; Miscanthus; aluminum; biomass production; calcium; catechin; cellulose; chlorogenic acid; chromium; cobalt; colchicine; copper; energy; energy crops; grasses; hexaploidy; high performance liquid chromatography; iron; lead; leaf extracts; leaves; lignin; magnesium; manganese; myricetin; nickel; photosynthesis; potassium; pyrogallol; selenium; silicon; sodium; spectroscopy; strontium; sulfur; triploidy; warm season; zinc
Abstract:
... Giant Miscanthus (Miscanthus×giganteus) is a perennial, warm-season C4 grass. It is a sterile triploid that grows rapidly, accumulates significant biomass, and has the potential to be a new bioenergy crop. Hexaploid Miscanthus×giganteus can be induced from triploid M×giganteus using colchicine. Here, we compared a range of parameters between triploid and hexaploid plants using phytochemical and hi ...
DOI:
10.1016/j.indcrop.2016.04.051

38. Assessment of the bioactive phenolic composition of Acer truncatum seed coat as a byproduct of seed oil

Author:
Hang Fan; Liwei Sun; Lingguang Yang; Jinchi Zhou; Peipei Yin; Ke Li; Qiang Xue; Xiang Li; Yujun Liu
Source:
Industrial crops and products 2018 v.118 pp. 11-19
ISSN:
0926-6690
Subject:
2,2-diphenyl-1-picrylhydrazyl; 2,5-dihydroxybenzoic acid; Acer truncatum; acetone; antioxidant activity; antioxidants; byproducts; epicatechin; ethanol; manufacturing; naringenin; proanthocyanidins; procyanidins; seed coat; seed oils; tannins; wastes
Abstract:
... Acer truncatum seed coat is generally abandoned as waste during the process of manufacturing seed oil due to a lack of knowledge of the phytochemical composition of this byproduct. It is well known that brown-colored seed coat is rich in polyphenols; therefore, we investigated the bioactive phenolic composition of A. truncatum seed coat in this study. To obtain an extract containing most bioactive ...
DOI:
10.1016/j.indcrop.2018.03.030

39. Automated Dispersive Solid-Phase Extraction Using Dissolvable Fe3O4-Layered Double Hydroxide Core–Shell Microspheres as Sorbent

Author:
Tang Sheng; Chia Guo Hui; Chang Yuepeng; Lee Hian Kee
Source:
Analytical chemistry 2014 v.86 no.22 pp. 11070-11076
ISSN:
1520-6882
Subject:
2,5-dihydroxybenzoic acid; agitation; aspirin; automation; centrifugation; detection limit; high performance liquid chromatography; pH; personal care products; sewage; solid phase extraction; statistical analysis; temperature
Abstract:
... Automation of dispersive solid-phase extraction (d-SPE) presents significant challenges. Separation of the sorbent from the spent sample cannot be conducted without manual operations, including centrifugation, a widely used means of isolating a solid material from solution. In this work, we report an approach to d-SPE using dissolvable magnetic Fe₃O₄-layered double hydroxide core–shell microsphere ...
DOI:
10.1021/ac503323e

40. Automated normal phase nano high performance liquid chromatography/matrix assisted laser desorption/ionization mass spectrometry for analysis of neutral and acidic glycosphingolipids

Author:
Zarei, Mostafa; Kirsch, Stephan; Müthing, Johannes; Bindila, Laura; Peter-Katalinić, Jasna
Source:
Analytical and bioanalytical chemistry 2008 v.391 no.1 pp. 289-297
ISSN:
1618-2642
Subject:
2,5-dihydroxybenzoic acid; cations; crystallization; desorption; erythrocytes; glycosphingolipids; high performance liquid chromatography; humans; ionization; lithium; mass spectrometry; mice; screening; solvents
Abstract:
... The coupling of nano high-performance liquid chromatography (nanoHPLC) with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) via an automatic spotting roboter was developed and adapted for the first time for the analysis of complex mixtures of glycosphingolipids (GSLs). The 2,5-dihydroxybenzoic acid and 6-azo-2-thiothymine matrix systems were adjusted to concurrently meet ...
DOI:
10.1007/s00216-008-1932-0
PubMed:
18327675

41. Banana plant as a source of valuable antimicrobial compounds and its current applications in the food sector

Author:
Heba Sayed Mostafa
Source:
Journal of food science 2021 v.86 no.9 pp. 3778-3797
ISSN:
0022-1147
Subject:
2,5-dihydroxybenzoic acid; Musa; anti-infective agents; antioxidants; bananas; beverages; bio-packaging; biopreservatives; carene; cultivars; dopamine; ferulic acid; food industry; food storage; fruits; lupeol; meat; perishable foods; prebiotics; sucrose; value added; wastes; wheat
Abstract:
... Bananas (Musaceae) are one of the world's most common fruit crops and the oldest medicinal plants that are used to treat a variety of infections. There has been recent interest in elucidating the efficiency of the naturally active ingredients, particularly the antimicrobials, in this plant. This review begins with a short background of the banana plant and its cultivars as well as a brief descript ...
DOI:
10.1111/1750-3841.15854

42. Bioaccessibility and antioxidant activity of phenolic compounds in frozen pulps of Brazilian exotic fruits exposed to simulated gastrointestinal conditions

Author:
Rodrigo Luiz Targino Dutra; Aline Macedo Dantas; Débora de Araújo Marques; Jéssica Dayanne Ferreira Batista; Bruno Raniere Lins de Albuquerque Meireles; Ângela Maria Tribuzy de Magalhães Cordeiro; Marciane Magnani; Graciele da Silva Campelo Borges
Source:
Food research international 2017 v.100 pp. 650-657
ISSN:
0963-9969
Subject:
2,5-dihydroxybenzoic acid; antioxidant activity; bioavailability; gallic acid; gastrointestinal system; introduced plants; iron; pulp
Abstract:
... This study characterized the phenolic profile in siriguela, umbu-cajá and mangaba, as well in their frozen pulps (FPs). The bioaccessibility of phenolic compounds and the antioxidant activity of the FP dialysates were determined following exposure to simulated gastrointestinal conditions. The profile of phenolic compounds identified in fruit and FPs were relatively similar. After pulp processing, ...
DOI:
10.1016/j.foodres.2017.07.047

43. Bioactivities and phenolic constituents relationship of Muğla thyme and pine honey of Turkey with the chemometric approach

Author:
Yusuf Sıcak; Ayşe Şahin-Yağlıoğlu; Mehmet Öztürk
Source:
Journal of food measurement & characterization 2021 v.15 no.4 pp. 3694-3707
ISSN:
2193-4126
Subject:
2,5-dihydroxybenzoic acid; 4-hydroxybenzoic acid; alpha-tocopherol; anti-inflammatory activity; antioxidant activity; antioxidants; brain; breasts; butylated hydroxytoluene; chemometrics; chlorogenic acid; cholinesterase; cinnamic acid; colon; ethyl acetate; fluorouracil; fumaric acid; honey; measurement; neoplasm cells; odors; protocatechuic acid; salicylic acid; syringic acid; taste; therapeutics; thyme; urease; vanillic acid
Abstract:
... The chemical ingredients of pine and thyme honey were studied, along with their medicinal activity properties. A method was validated for common honey compounds using LC-TOF/MS to analyze the ingredients. In vitro antiproliferative, antioxidant, anticholinesterase, anti-inflammatory, tyrosinase inhibitory, and urease inhibitory activities were used to investigate the therapeutic potentials. The an ...
DOI:
10.1007/s11694-021-00940-8

44. Biodegradation Mechanism of Phenanthrene by Halophilic Hortaea sp. B15

Author:
Risky Ayu Kristanti; Tony Hadibarata; Dunia A. Al Farraj; Mohamed Soliman Elshikh; Roua M. Alkufeidy
Source:
Water, air, and soil pollution 2018 v.229 no.10 pp. 324
ISSN:
0049-6979
Subject:
2,5-dihydroxybenzoic acid; bacteria; biodegradation; bioremediation; fungi; liquids; phenanthrenes; polluted soils; quinones; salicylic acid; salinity; spectral analysis; spectrophotometers
Abstract:
... This aim of the study is to investigate a halophilic bacterium Hortaea sp. B15, isolated from petroleum-contaminated soil for biodegradation of phenanthrene. Hortaea sp. B15 has the ability to completely degrade phenanthrene (100 mg/L) under salinity 10% within 1-week incubation. The metabolitic product of phenanthrene was identified and assayed by using ultraviolet-visible spectrophotometer and m ...
DOI:
10.1007/s11270-018-3969-9

45. Biodegradation of p-Cresol by Bacillus sp. Strain PHN 1

Author:
Tallur, P. N.; Megadi, V. B.; Kamanavalli, C. M.; Ninnekar, H. Z.
Source:
Current microbiology 2006 v.53 no.6 pp. 529-533
ISSN:
0343-8651
Subject:
2,5-dihydroxybenzoic acid; 4-hydroxybenzoic acid; Bacillus (bacteria); bacteria; biodegradation; bioremediation; carbon; energy; enzyme activity; o-cresol; p-cresol; phenol; soil
Abstract:
... A bacterium capable of utilizing p-cresol as sole source of carbon and energy was isolated from soil and identified as a Bacillus species. The organism also utilized phenol, o-cresol, m-cresol, 4-hydroxybenzoic acid, and gentisic acid as growth substrates. The organism degraded p-cresol to 4-hydroxybenzoic acid, which was further metabolized by a gentisate pathway, as evidenced by isolation and id ...
DOI:
10.1007/s00284-006-0309-x
PubMed:
17106800

46. Biotransformation of indole by Cupriavidus sp. strain KK10 proceeds through N-heterocyclic- and carbocyclic-aromatic ring cleavage and production of indigoids

Author:
Kimiko Fukuoka; Keita Tanaka; Yasuhiro Ozeki; Robert A. Kanaly
Source:
International Biodeterioration & Biodegradation 2015 v.97 pp. 13-24
ISSN:
0964-8305
Subject:
2,5-dihydroxybenzoic acid; Cupriavidus; biobased products; biotransformation; electrospray ionization mass spectrometry; genes; indigo; liquid chromatography; oxidation; phylogeny; pollutants; ribosomal RNA; soil bacteria
Abstract:
... Comprehensive analyses of the biotransformation of the N-heteroaromatic environmental pollutant, indole, by a newly isolated soil bacterium designated strain KK10, were conducted by liquid chromatography negative electrospray ionization tandem mass spectrometry (LC/ESI(−)–MS/MS). Numerous indole bioproducts were revealed and provided evidence for multiple pathways of indole biotransformation by th ...
DOI:
10.1016/j.ibiod.2014.11.007

47. Bithiophenic MALDI matrices as valuable leads for the selective detection of alkaloids

Author:
Ali Jaber; Denis Seraphin; David Guilet; Junichi Osuga; Edmond Cheble; Ghassan Ibrahim; Pascal Richomme; Andreas Schinkovitz
Source:
Analytical and bioanalytical chemistry 2017 v.409 no.29 pp. 6791-6801
ISSN:
1618-2642
Subject:
2,5-dihydroxybenzoic acid; Atropa belladonna; Colchicum autumnale; Senecio vulgaris; detection limit; dietary supplements; flavonoids; humans; liquid chromatography; mass spectrometry; peptides; quality control; sparteine; steroids
Abstract:
... Alkaloids represent a group of biologically most interesting compounds commonly used in modern medicines but also known for exhibiting severe toxic effects. Therefore, the detection of alkaloids is an important issue in quality control of plants, dietary supplements, and herbal pharmaceutical and mostly facilitated by methods such as GC or LC-MS. However, benefitting from the development of select ...
DOI:
10.1007/s00216-017-0634-x

48. Bound phenolic compounds and antioxidant properties of whole grain and bran of white, red and black rice

Author:
Yuehan Pang; Sulaiman Ahmed; Yanjie Xu; Trust Beta; Zhiwei Zhu; Yafang Shao; Jinsong Bao
Source:
Food chemistry 2018 v.240 pp. 212-221
ISSN:
0308-8146
Subject:
2,5-dihydroxybenzoic acid; antioxidant activity; black rice; bran; color; ferulic acid; gallic acid; p-coumaric acid; phytopharmaceuticals; protocatechuic acid; sinapic acid; vanillic acid; whole grain foods
Abstract:
... Total phenolic content (TPC), individual phenolic acid and antioxidant capacity of whole grain and bran fraction 18 rices with different bran color were investigated. The levels of TPC in bound fractions were significantly higher than those in the free fractions either in the whole grains or brans. The main bound phenolic acids in white rice samples were ferulic acid, p-coumaric acid, and isoferul ...
DOI:
10.1016/j.foodchem.2017.07.095

49. Carbohydrates, volatile and phenolic compounds composition, and antioxidant activity of calabura (Muntingia calabura L.) fruit

Author:
Gustavo Araujo Pereira; Henrique Silvano Arruda; Damila Rodrigues de Morais; Marcos Nogueira Eberlin; Glaucia Maria Pastore
Source:
Food research international 2018 v.108 pp. 264-273
ISSN:
0963-9969
Subject:
2,5-dihydroxybenzoic acid; Muntingia calabura; antioxidant activity; bioactive compounds; caffeic acid; catechin; color; energy; epigallocatechin; esterification; flavor; food industry; fructose; fruits; functional foods; gallic acid; gas chromatography-mass spectrometry; glucose; glycosylation; naringenin; polyols; protocatechuic acid; quercetin; solid phase microextraction; tandem mass spectrometry; terpenoids; volatile compounds
Abstract:
... Soluble carbohydrates, volatile and phenolic compounds from calabura fruit as well as its antioxidant activity were assessed. The low amount of fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) and similar amount of glucose and fructose allow us to classify the calabura berry as low-FODMAPs. The terpenes β-Farnesene and dendrolasin identified by SPME-GC-MS were the major volatile ...
DOI:
10.1016/j.foodres.2018.03.046

50. Cardiovascular protection effect of a Northeastern Brazilian lyophilized red wine in spontaneously hypertensive rats

Author:
Natália T.M. Calzerra; Mayara P. Melo; Pablo F. Santos; Kívia S. Assis; Priscilla M.P. Maciel; Renata L.P. Vieira; Fátima de L.A.A. Azevedo; Angela M.T.M. Cordeiro; Bruno R.L.A. Meireles; Islania G.A. Araújo; Robson C. Veras; Isac A. Medeiros
Source:
Journal of functional foods 2022 v.88 pp. 104868
ISSN:
1756-4646
Subject:
2,5-dihydroxybenzoic acid; blood pressure; cardioprotective effect; cardiovascular system; catechin; collagen; freeze drying; high performance liquid chromatography; oxidative stress; red wines; resveratrol; Brazil
Abstract:
... Moderate consumption of wine has a protective effect on the cardiovascular system. This study proposes to investigate the cardiovascular protective effect of the lyophilized red wine RIO SOL Cabernet-Sauvignon (LRW-RSCS), produced in Northeastern Brazil, in SHR. Sixteen different phenolic compounds, such as gentisic acid, catechin, and resveratrol were identified in LRW-RSCS using high-performance ...
DOI:
10.1016/j.jff.2021.104868

51. Characterization and application of Croton blanchetianus Baill extract for lamb ribs preservation

Author:
Maria José de Figueiredo; Cristiani Viegas Brandão Grisi; Ângela Maria Santiago; Erica de Andrade Vieira; Angela Maria Tribuzy de Magalhães Cordeiro; Anderson Ferreira Vilela; Arianne Dantas Viana; Solange de Sousa; Líbia de Sousa Conrado
Source:
Food chemistry 2022 v.373 pp. 131404
ISSN:
0308-8146
Subject:
2,5-dihydroxybenzoic acid; 4-hydroxybenzoic acid; Artemia salina; Aspergillus flavus; Croton; Escherichia coli; Listeria innocua; Salmonella enterica; Staphylococcus aureus; absorbents; antimicrobial properties; antioxidant activity; antioxidants; catechin; cold storage; food chemistry; heat treatment; leaf extracts; lethal dose 50; lipid peroxidation; myricetin; ovens; rosmarinic acid
Abstract:
... This research evaluated the antioxidant, antimicrobial and toxicity potential of the leaf extract of Croton blanchetianus Baill (ExCb) and its effect on the conservation of lamb ribs. The ExCb (control treatment) revealed higher concentration of 2,5-dihydroxybenzoic acid (190.10 mg/g), catechin (84.10 mg/g), rosmarinic acid (56.01 mg/g), 4-hydroxybenzoic acid (52.05 mg/g) and myricetin (40.00 mg/g ...
DOI:
10.1016/j.foodchem.2021.131404

52. Characterization of natural wax esters by MALDI-TOF mass spectrometry

Author:
Vrkoslav, Vladimír; Míková, Radka; Cvačka, Josef
Source:
Journal of mass spectrometry 2009 v.44 no.1 pp. 101-110
ISSN:
1076-5174
Subject:
2,5-dihydroxybenzoic acid; Ginkgo biloba; carbon; cesium; copper; desorption; detection limit; gas chromatography-mass spectrometry; glass; insects; ionization; ions; isotopes; leaf extracts; lithium; matrix-assisted laser desorption-ionization mass spectrometry; mixing; molecular weight; potassium; rubidium; salts; sampling; scanning electron microscopy; silver; sodium; solubility; solvents; wax esters
Abstract:
... The applicability of matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) to the analysis of wax esters (WEs) was investigated. A series of metal salts of 2,5-dihydroxybenzoic acid (DHB) was synthesized and tested as possible matrices. Alkali metal (Li, Na, K, Rb, Cs) and transition metal (Cu, Ag) salts were studied. The matrix properties were evaluated, incl ...
DOI:
10.1002/jms.1476

53. Chemical Constituents of Boea hygrometrica

Author:
Wei-Sheng FENG; Yuan-Jing LI; Xiao-Ke ZHENG; Yan-Zhi WANG; Fang-Yi SU
Source:
Chinese journal of natural medicines 2011 v.9 no.6 pp. 406-409
ISSN:
1875-5364
Subject:
2,5-dihydroxybenzoic acid; chemical composition; chromatography; ferulic acid; silica gel; spectral analysis
Abstract:
... AIM: To study the chemical constituents of Boea hygrometrica (Bunge.) R. Br. METHODS: The compounds were isolated and purified by Diaion HP-20, Toyopearl HW-40, silica gel column chromatography and the structures were identified on the basis of spectral data and physiochemical properties. RESULTS: Seven compounds were obtained and identified as 5,7,3′4′-tetrahydroxy-6-methoxy-8-C-[β-D-xylopyranosy ...
DOI:
10.3724/SP.J.1009.2011.00406

54. Chemical profiling, in vitro biological activities and Pearson correlation between chemical profiling and anticancer activities of four Abies species from Turkey

Author:
Ayse Sahin Yaglioglu; Muhammet Samil Yaglioglu; Nahide Tosyalıoglu; Sevki Adem; Ibrahim Demirtas
Source:
South African journal of botany 2022 v. no. pp. -
ISSN:
0254-6299
Subject:
2,5-dihydroxybenzoic acid; Abies cilicica; Abies nordmanniana subsp. equi-trojani; Abies nordmanniana subsp. nordmanniana; Turkey (country); antineoplastic activity; catechin; chemical constituents of plants; drugs; oleic acid; palmitic acid; phytopharmaceuticals; principal component analysis; prostaglandin synthase; solvents; stearic acid; synergism
Abstract:
... Abies species are known to have various bioactive compounds and pharmacological activities. In the manuscript, their bioactive components and anticancer activities of four unexamined Abies in Anatolia (Abies cilicica subsp. isaurica, Abies nordmanniana subsp. nordmanniana, Abies nordmanniana subsp. bornmuelleriana, Abies nordmanniana subsp. equi-trojani) were investigated. The principal component ...
DOI:
10.1016/j.sajb.2022.08.005

55. Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry

Author:
Dominika Houdová; Juan Soto; Rita Castro; João Rodrigues; Mª Soledad Pino-González; Marijana Petković; Teresa J Bandosz; Manuel Algarra
Source:
Journal of colloid and interface science 2021 v.591 pp. 373-383
ISSN:
0021-9797
Subject:
2,5-dihydroxybenzoic acid; Gibbs free energy; cholesterol; desorption; ionization; matrix-assisted laser desorption-ionization mass spectrometry; models
Abstract:
... A binary system composed of carbon dots (CDs) and N-doped CDs (N-CDs) embedded in an organic matrix was used for the analysis of cholesterol by MALDI (matrix-assisted laser desorption and ionization time-of-flight) mass spectrometry, as a model for detection of small, biologically relevant molecules. The results showed that both CDs are sensitive to the cholesterol and can be used either alone or ...
DOI:
10.1016/j.jcis.2021.02.004

56. Chitosan nanoparticles loaded with 2,5-dihydroxybenzoic acid and protocatechuic acid: Properties and digestion

Author:
Ana Raquel Madureira; Adriana Pereira; Manuela Pintado
Source:
Journal of food engineering 2016 v.174 pp. 8-14
ISSN:
0260-8774
Subject:
2,5-dihydroxybenzoic acid; antioxidant activity; bioactive compounds; chitosan; differential scanning calorimetry; digestion; energy; food matrix; functional foods; gastrointestinal system; gelation; ingredients; light scattering; melting; models; molecular weight; nanoparticles; polyphenols; protocatechuic acid; temperature; thermal properties
Abstract:
... Research efforts on the production of chitosan nanoparticles (NP) as delivery systems of bioactive compounds such as polyphenols have been made along the last decade. Nevertheless, the effect of the phenolic compound structure in the production of these NP was never evaluated so far. Low and high molecular weights chitosan (LMWC and HMWC) NP loaded with the phenolic acids, protocatechuic (PA) and ...
DOI:
10.1016/j.jfoodeng.2015.11.007

57. Combining tissue extraction and off-line capillary electrophoresis matrix-assisted laser desorption/ionization Fourier transform mass spectrometry for neuropeptide analysis in individual neuronal organs using 2,5-dihydroxybenzoic acid as a multi-functional agent

Author:
Wang, Junhua; Jiang, Xiaoyue; Sturm, Robert M.; Li, Lingjun
Source:
Journal of chromatography 2009 v.1216 no.47 pp. 8283-8288
ISSN:
0021-9673
Subject:
2,5-dihydroxybenzoic acid; Cancer borealis; aqueous solutions; capillary electrophoresis; chromatography; crabs; desorption; drying; electrolytes; ionization; mass spectrometry; neuropeptides
Abstract:
... In this study we report an improved protocol that combines simplified sample preparation and micro-scale separation for mass spectrometric analysis of neuropeptides from individual neuroendocrine organs of crab Cancer borealis. A simple, one-step extraction method with commonly used matrix-assisted laser desorption/ionization (MALDI) matrix, 2,5-dihydroxybenzoic acid (DHB), in saturated aqueous so ...
DOI:
10.1016/j.chroma.2009.04.085
PubMed:
19473662
PubMed Central:
PMC2783529

58. Comparative TOF-SIMS and MALDI TOF-MS analysis on different chromatographic planar substrates

Author:
Talian, Ivan; Orinák, Andrej; Preisler, Jan; Heile, Andreas; Onofrejová, Lucie; Kaniansky, Dušan; Arlinghaus, Heinrich F.
Source:
Journal of separation science 2007 v.30 no.16 pp. 2570-2582
ISSN:
1615-9306
Subject:
2,5-dihydroxybenzoic acid; Raman spectroscopy; chromatography; desorption; ferulic acid; gibberellic acid; ionization; mass spectrometry; silica gel
Abstract:
... A comparison is made between two high resolution, surface-based, mass spectrometric methods: time-of-flight secondary ion mass spectrometry (TOF-SIMS) and matrix-assisted laser desorption/ionisation mass spectrometry (MALDI TOF-MS) in indication of abietic and gibberellic acids molecular profiles on different chromatographic thin layers. The analytes were applied to silica gel chromatographic thin ...
DOI:
10.1002/jssc.200700120
PubMed:
17876765

59. Comparative assessment of phenolics, antioxidant and antiproliferative activities between Hippophae rhamnoides ssp. sinensis and H. tibetana leaf in Qinghai-Tibet Plateau

Author:
Juan Wei; Tingting Su; Hailan Su; Yumei Jiang; Jixin Li; Yang Bi
Source:
Food bioscience 2022 v.46 pp. 101507
ISSN:
2212-4292
Subject:
2,5-dihydroxybenzoic acid; 4-hydroxybenzoic acid; Hippophae rhamnoides; antioxidant activity; benzoic acid; chlorides; cyanidin; ellagic acid; epigallocatechin; ethanol; flavanols; flavanones; free radicals; healthy diet; leaves; methyl gallate; myrtillin; procyanidins; rutin; taxifolin; China
Abstract:
... Hippophae rhamnoides ssp. sinensis (Rha) and H. tibetana (Tib) are two species of sea buckthorn which distribute in Qinghai-Tibet Plateau. Our results showed that both sea buckthorn leaf exhibited high total phenolic and flavonoid content, and Rha leaf showed much higher level. In addition, 66 phenolic compounds were detected, belonging to classes of benzoic acid derivatives, flavonols, flavanols, ...
DOI:
10.1016/j.fbio.2021.101507

60. Comparative phenolic compound profiles and antioxidative activity of the fruit, leaves, and roots of Korean ginseng (Panax ginseng Meyer) according to cultivation years

Author:
Ill-Min Chung; Ju-Jin Lim; Mun-Seob Ahn; Haet-Nim Jeong; Tae-Jin An; Seung-Hyun Kim
Source:
Journal of Ginseng Research 2016 v.40 no.1 pp. 68-75
ISSN:
1226-8453
Subject:
2,5-dihydroxybenzoic acid; Panax ginseng; antioxidant activity; chlorogenic acid; ferulic acid; fruits; p-coumaric acid; phenol; research; rutin; ultra-performance liquid chromatography
Abstract:
... The study of phenolic compounds profiles and antioxidative activity in ginseng fruit, leaves, and roots with respect to cultivation years, and has been little reported to date. Hence, this study examined the phenolic compounds profiles and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free-radical-scavenging activities in the fruit, leaves, and roots of Korean ginseng (Panax ginseng Meyer) as a function o ...
DOI:
10.1016/j.jgr.2015.05.006

61. Comparison of Phenolic Compounds, Carotenoids, Amino Acid Composition, In Vitro Antioxidant and Anti-Diabetic Activities in the Leaves of Seven Cowpea (Vigna unguiculata) Cultivars

Author:
Mapula R. Moloto; Anh Dao T. Phan; Jerry L. Shai; Yasmina Sultanbawa; Dharini Sivakumar
Source:
Foods 2020 v.9 no.9 pp. -
ISSN:
2304-8158
Subject:
2,5-dihydroxybenzoic acid; Vigna unguiculata; alpha-amylase; amino acid composition; antioxidant activity; antioxidants; assays; correlation; cowpeas; cultivars; cytotoxicity; essential amino acids; functional foods; gene expression; genotype; glucose transporters; glycemic effect; information; ingredients; insulin; leaf extracts; leaves; lutein; metabolites; myocytes; nutrition; quercetin; risk reduction; skeletal muscle; Sub-Saharan Africa
Abstract:
... Cowpea is a well-known nutrition rich African leafy vegetable that has potential to sustain food and nutrition insecurity in sub-Saharan Africa. Consumption of cowpea legumes is associated with reduced risk of type 2 diabetes mellitus. Therefore, the present study was designed to evaluate the (i) variation in phenolic metabolites in seven cowpea cultivars (VOP1, VOP2, VOP3, VOP4, VOP5, VOP7, and V ...
DOI:
10.3390/foods9091285

62. Comparison of motility, recovery, and methyl-thiazolyl-tetrazolium reduction assays for use in screening plant products for anthelmintic activity

Author:
Smith, Robert A.; Pontiggia, Laura; Waterman, Carrie; Lichtenwalner, Meghan; Wasserman, Jared
Source:
Parasitology research 2009 v.105 no.5 pp. 1339-1343
ISSN:
0932-0113
Subject:
2,5-dihydroxybenzoic acid; Anogeissus; Caenorhabditis elegans; gallic acid; high performance liquid chromatography; levamisole; plant extracts; salts
Abstract:
... The primary objective of these experiments was to compare the effectiveness of motility, recovery, and methyl-thiazolyl-tetrazolium (MTT) reduction assays for determining anthelmintic activity of plant extracts and purified compounds from these extracts. Caenorhabditis elegans was used as the test organism. High-performance liquid chromatography (HPLC) grade water and M9 medium were used as the so ...
DOI:
10.1007/s00436-009-1560-4
PubMed:
19629527

63. Comparison of sample pre-treatments for laser desorption ionization and secondary ion mass spectrometry imaging of Miscanthus × giganteus

Author:
Li, Zhen; Bohn, Paul W.; Sweedler, Jonathan V.
Source:
Bioresource technology 2010 v.101 no.14 pp. 5578-5585
ISSN:
0960-8524
Subject:
2,5-dihydroxybenzoic acid; Miscanthus; carbohydrates; chemical speciation; coatings; desorption; feedstocks; fuel production; grasses; image analysis; ionization; ions; lasers; mass spectrometry; metals; vascular bundles
Abstract:
... Efforts to further the potential of the large perennial grass Miscanthus × giganteus as a biofuel feedstock would be aided by the ability to image the chemical species present during the fuel production process. Toward this end, two mass spectrometry imaging (MSI) approaches have been investigated here—laser desorption/ionization mass spectrometry (LDI-MS) and secondary ion mass spectrometry (SIMS ...
DOI:
10.1016/j.biortech.2010.01.136

64. Composition and antioxidant, antibacterial, and anti-HepG2 cell activities of polyphenols from seed coat of Amygdalus pedunculata Pall

Author:
Cairui Lu; Cong Li; Bang Chen; Yehua Shen
Source:
Food chemistry 2018 v.265 pp. 111-119
ISSN:
0308-8146
Subject:
2,2-diphenyl-1-picrylhydrazyl; 2,5-dihydroxybenzoic acid; Aspergillus niger; Bacillus cereus; Bacillus subtilis; Escherichia coli; Prunus; Staphylococcus aureus; antibacterial properties; antineoplastic activity; antineoplastic agents; antioxidant activity; apigenin; apoptosis; ascorbic acid; cell proliferation; cell viability; cyanidin; free radicals; gallic acid; human cell lines; hydrogen peroxide; iron; kaempferol; keracyanin; naringenin; polyphenols; quercetin; quercitrin; seed coat; superoxide anion; viability assays
Abstract:
... This study aims at identifying the composition of polyphenols present in Amygdalus pedunculata Pall seed coat (APSC), and characterizing their antioxidant, antibacterial, and anticancer activities. The polyphenols from APSC were composed of 32 compounds. The compounds with important biological activities included apigenin 7-O-glucoside (the main component; 34.53 mg/100 g), quercitrin (23.43 mg/100 ...
DOI:
10.1016/j.foodchem.2018.05.091

65. Comprehensive characterization by UHPLC-ESI-Q-TOF-MS from an Eryngium bourgatii extract and their antioxidant and anti-inflammatory activities

Author:
María de la Luz Cádiz-Gurrea; Salvador Fernández-Arroyo; Jorge Joven; Antonio Segura-Carretero
Source:
Food research international 2013 v.50 no.1 pp. 197-204
ISSN:
0963-9969
Subject:
Eryngium bourgatii; anti-inflammatory activity; foods; kaempferol; reactive oxygen species; coumarins; syringic acid; roots; sinusitis; 4-hydroxybenzoic acid; saponins; isorhamnetin; leaves; traditional medicine; antioxidant activity; quercetin; polyacetylenes; naringenin; caffeic acid; monoterpenoids; 2,5-dihydroxybenzoic acid; flowers; edema
Abstract:
... The genus Eryngium (family Apiaceae) consists of about 300 species. This genus is known to contain polyacetylenes, flavonoids and saponins, coumarins, and monoterpene glycosides. In folk medicine, various species are used for a wide range of foods; particularly roots are used against various inflammatory disorders, oedema, sinusitis, urinary infections, etc. The aim of the present study was to cha ...
DOI:
10.1016/j.foodres.2012.09.038

66. Comprehensive metabolite profiling of Solanum tuberosum L. (potato) leaves by HPLC-ESI-QTOF-MS

Author:
Celia Rodríguez-Pérez; Ana María Gómez-Caravaca; Eduardo Guerra-Hernández; Lorenzo Cerretani; Belen García-Villanova; Vito Verardo
Source:
Food research international 2018 v.112 pp. 390-399
ISSN:
0963-9969
Subject:
2,5-dihydroxybenzoic acid; Solanum tuberosum; amino acids; bioactive compounds; flavonoids; functional foods; high performance liquid chromatography; iridoids; leaf extracts; leaves; metabolites; oxylipins; potatoes; quinic acid
Abstract:
... The objective of this work was to study the non-targeted metabolite profiling of potato leaves using high performance liquid chromatography coupled to quadrupole-time of flight mass spectrometry (HPLC-ESI-QTOF-MS). The mass accuracy, true isotopic pattern in both MS and MS/MS spectra provided by QTOF-MS made possible the tentative identification of 109 compounds present in potato leaves, including ...
DOI:
10.1016/j.foodres.2018.06.060

67. Constituents of Cocoa Husks

Author:
Josep Serra Bonvehí; Rossend Escolá Jordà
Source:
Zeitschrift für Naturforschung 2014 v.53 no.9-10 pp. 785-792
ISSN:
1865-7125
Subject:
2,5-dihydroxybenzoic acid; Recommended Dietary Allowances; Theobroma cacao; alkaloids; argon (noble gases); caffeic acid; calcium; chromium; cocoa beans; cocoa hulls; copper; high performance liquid chromatography; iron; magnesium; mineral content; phytic acid; polyphenols; potassium; sodium; spectrometers; sugars; vitamins; zinc; Africa; South America
Abstract:
... Mineral composition, vitamins (group B, C and D), polyphenols, purine alkaloids, sugars and phytic acid were determined in twelve samples of cocoa husk of the main varieties of cocoa beans (Theobroma cacao L.) cultivated in Africa and South America. Macro- (K, Mg, Ca, Na, P, and Na) and micro elements (Cu, Zn, Fe, and Cr) were quantified using an inductively coupled argon plasma-optical emission s ...
DOI:
10.1515/znc-1998-9-1002

68. Control of Endophytic Frankia Sporulation by Alnus Nodule Metabolites

Author:
Anne-Emmanuelle Hay; Hasna Boubakri; Antoine Buonomo; Marjolaine Rey; Guillaume Meiffren; Laetitia Cotin-Galvan; Gilles Comte; Aude Herrera-Belaroussi
Source:
Molecular plant-microbe interactions 2017 v.30 no.3 pp. 205-214
ISSN:
0894-0282
Subject:
2,5-dihydroxybenzoic acid; Alnus glutinosa; Frankia; amino acids; dormancy; endophytes; metabolomics; pathogens; secondary metabolites; sporulation; sugars; symbionts; symbiosis
Abstract:
... A unique case of microbial symbiont capable of dormancy within its living host cells has been reported in actinorhizal symbioses. Some Frankia strains, named Sp+, are able to sporulate inside plant cells, contrarily to Sp− strains. The presence of metabolically slowed-down bacterial structures in host cells alters our understanding of symbiosis based on reciprocal benefits between both partners, a ...
DOI:
10.1094/MPMI-11-16-0235-R

69. Coumarins as new matrices for matrix-assisted laser-desorption/ionization Fourier transform ion cyclotron resonance mass spectrometric analysis of hydrophobic compounds

Author:
Hang Wang; Bona Dai; Bin Liu; Han Lu
Source:
Analytica chimica acta 2015 v.882 pp. 49-57
ISSN:
0003-2670
Subject:
2,5-dihydroxybenzoic acid; aldehydes; analytical chemistry; cholesterol; coenzyme Q10; coumarin; desorption; detection limit; hydrophobicity; ionization; lipopeptides; mass spectrometry; oleic acid; screening; sodium chloride; umbelliferones; yeasts
Abstract:
... Hydrophobic compounds with hydroxyl, aldehyde or ketone groups are generally difficult to detect using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), because these compounds have low proton affinity and are poorly ionized by MALDI. Herein, coumarins have been used as new matrices for MALDI-MS analysis of a variety of hydrophobic compounds with low ionization efficiency, ...
DOI:
10.1016/j.aca.2015.04.050

70. Daily consumption of cranberry improves endothelial function in healthy adults: a double blind randomized controlled trial

Author:
Christian Heiss; Geoffrey Istas; Rodrigo P. Feliciano; Timon Weber; Brian Wang; Claudia Favari; Pedro Mena; Daniele Del Rio; Ana Rodriguez-Mateos
Source:
Food & function 2022 v.13 no.7 pp. 3812-3824
ISSN:
2042-650X
Subject:
2,5-dihydroxybenzoic acid; Internet; blood glucose; blood pressure; cranberries; glucose; heart rate; males; metabolites; propionic acid; regression analysis; urine
Abstract:
... Background: Previous studies indicate cardiovascular health benefits of cranberry juice consumption. However, whether daily consumption of whole cranberries will have sustained vascular benefits in healthy individuals is currently unknown. Objective: To investigate the vascular effects of acute and daily consumption of freeze dried whole cranberry in healthy men and how effects relate to circulati ...
DOI:
10.1039/d2fo00080f

71. Deregulated Tyrosine–Phenylalanine Metabolism in Pulmonary Tuberculosis Patients

Author:
Das Mrinal Kumar; Bishwal Subasa Chandra; Das Aleena; Dabral Deepti; Badireddy Vinod Kumar; Pandit Bhaswati; Varghese George M.; Nanda Ranjan Kumar
Source:
Journal of Proteome Research 2015 v.14 no.4 pp. 1947-1956
ISSN:
1535-3907
Subject:
2,5-dihydroxybenzoic acid; 4-hydroxybenzoic acid; biochemical pathways; chemometrics; diagnostic techniques; gas chromatography-mass spectrometry; hydroquinone; least squares; longitudinal studies; metabolism; metabolome; metabolomics; models; norepinephrine; pathophysiology; patients; phenylalanine; quinones; silylation; therapeutics; tuberculosis; tyrosine; urine
Abstract:
... Metabolic profiling of biofluids from tuberculosis (TB) patients would help us in understanding the disease pathophysiology and may also be useful for the development of novel diagnostics and host-directed therapy. In this pilot study we have compared the urine metabolic profiles of two groups of subjects having similar TB symptoms and categorized as active TB (ATB, n = 21) and non-TB (NTB, n = 21 ...
DOI:
10.1021/acs.jproteome.5b00016

72. Design of a method for generation of gas-phase hydroxyl radicals, and use of HPLC with fluorescence detection to assess the antioxidant capacity of natural essential oils

Author:
Pezo, D.; Salafranca, J.; Nerín, C.
Source:
Analytical and bioanalytical chemistry 2006 v.385 no.7 pp. 1241-1246
ISSN:
1618-2642
Subject:
essential oils; salicylic acid; reversed-phase high performance liquid chromatography; ultraviolet radiation; aqueous solutions; fluorescence; hydrogen peroxide; air; oxidation; ginger; Zingiber officinale; humans; detectors; oxidants; antioxidant activity; diet; hydroxyl radicals; 2,5-dihydroxybenzoic acid; quartz; pH; air flow
Abstract:
... The use of natural antioxidants is of increasing importance in the human diet, because they are recognised as compounds essential to health which minimize or delay the aging process. Despite apparent simplicity, however, it is very difficult to measure and quantify such properties, for which a robust analytical method is required. Because oxidation usually is caused by the presence of OH· radicals ...
DOI:
10.1007/s00216-006-0395-4
PubMed:
16570142

73. Design, synthesis and characterization of lysozyme–gentisic acid dual-functional conjugates with antibacterial/antioxidant activities

Author:
Hui Li; Yanxiong Pan; Chun Li; Zhongyu Yang; Jiajia Rao; Bingcan Chen
Source:
Food chemistry 2022 v.370 pp. 131032
ISSN:
0308-8146
Subject:
2,5-dihydroxybenzoic acid; antioxidant activity; antioxidants; chemical bonding; food chemistry; food industry; food waste; functional foods; lipid peroxidation; lysozyme; particle size
Abstract:
... Both microbiological and chemical food spoilages remain to be the major challenges in the food industry's efforts to combat food waste and loss because of the lack of high efficacy food preservatives. In this study, dual-functional conjugates that simultaneously suppress both lipid oxidation and microorganism growth are fabricated by covalently conjugating natural antioxidant gentisic acid (GA) on ...
DOI:
10.1016/j.foodchem.2021.131032
CHORUS:
10.1016/j.foodchem.2021.131032

74. Detection and activity evaluation of radical scavenging compounds by using DPPH free radical and on-line HPLC-DPPH methods

Author:
Donata Bandonienė; Michael Murkovic; Werner Pfannhauser; Petras Venskutonis; Dainora Gruzdienė
Source:
European food research & technology 2002 v.214 no.2 pp. 143-147
ISSN:
1438-2377
Subject:
2,5-dihydroxybenzoic acid; Salvia; catechin; epicatechin; high performance liquid chromatography; methanol; naringin; phloridzin; plant extracts; quantitative analysis; quercetin; reaction kinetics; screening; uric acid; vanillic acid
Abstract:
... The antiradical activity of crude extracts (80% methanol, 20% water) of S. officinalis, S. glutinosa, S. sclarea and S. aethiopis was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH·) radical scavenging method. For validation of this method several well known antioxidants (ascorbic acid-6-palmitate, gallic, chlorogenic, ferulic, caffeic, uric, gentisic and vanillic acids, catechin, querce ...
DOI:
10.1007/s00217-001-0430-9

75. Determination of Abundant Metabolite Matrix Adducts Illuminates the Dark Metabolome of MALDI-Mass Spectrometry Imaging Datasets

Author:
Moritz Janda; Brandon K. B. Seah; Dennis Jakob; Janine Beckmann; Benedikt Geier; Manuel Liebeke
Source:
Analytical chemistry 2021 v.93 no.24 pp. 8399-8407
ISSN:
1520-6882
Subject:
2,5-dihydroxybenzoic acid; analytical chemistry; automation; computer software; data collection; desorption; ionization; matrix-assisted laser desorption-ionization mass spectrometry; metabolites; metabolome; metabolomics; potassium; sodium
Abstract:
... Spatial metabolomics using mass spectrometry imaging (MSI) is a powerful tool to map hundreds to thousands of metabolites in biological systems. One major challenge in MSI is the annotation of m/z values, which is substantially complicated by background ions introduced throughout the chemicals and equipment used during experimental procedures. Among many factors, the formation of adducts with sodi ...
DOI:
10.1021/acs.analchem.0c04720

76. Determination of Chemical Constituents and Antioxidant Activities of Leaves and Stems from Jatropha cinerea (Ortega) Müll. Arg and Jatropha cordata (Ortega) Müll. Arg

Author:
Yeimi Cecilia Vega-Ruiz; Corina Hayano-Kanashiro; Nohemí Gámez-Meza; Luis Angel Medina-Juárez
Source:
Plants 2021 v.10 no.2 pp. -
ISSN:
2223-7747
Subject:
2,5-dihydroxybenzoic acid; Jatropha cordata; antioxidant activity; antioxidants; catechol; flavonoids; gallic acid; leaves; sap; secondary metabolites; traditional medicine; weather; Mexico
Abstract:
... Jatropha species have been shown to be an important source of secondary metabolites with different biological effects. Jatropha cinerea (Ortega) Müll. Arg and Jatropha cordata (Ortega) Müll. Arg are distributed in the Northwestern region of Mexico, are adapted to extreme weather conditions and are widely used (stems, leaves, and sap) in traditional medicine. The aim of the present study was to car ...
DOI:
10.3390/plants10020212

77. Determination of acetylsalicylic acid and its major metabolites in bovine urine using ultra performance liquid chromatography

Author:
M.L. Castillo-García; M.P. Aguilar-Caballos; A. Gómez-Hens
Source:
Journal of Chromatography B 2015 v.985 pp. 85-90
ISSN:
1570-0232
Subject:
2,5-dihydroxybenzoic acid; aspirin; cattle; detection limit; fluorescence; fluorometry; food production; high performance liquid chromatography; metabolites; pH; salicylic acid; ultra-performance liquid chromatography; urine; veterinary drugs
Abstract:
... A new method based on ultra high performance liquid chromatography (UPLC) with photometric and fluorometric detection for the determination of acetylsalicylic acid and its main metabolites, namely gentisic, salicylic and salicyluric acids, in bovine urine samples is reported. Photometric detection was used for acetylsalicylic acid determination, whereas the native fluorescence of the metabolites w ...
DOI:
10.1016/j.jchromb.2015.01.026

78. Determination of the triacylglycerol content for the identification and assessment of purity of shea butter fat, peanut oil, and palm kernel oil using maldi-tof/tof mass spectroscopic technique

Author:
Mercy Badu; A. M. Johannes Awudza
Source:
International journal of food properties 2017 v.20 no.2 pp. 271-280
ISSN:
1094-2912
Subject:
2,5-dihydroxybenzoic acid; chloroform; desorption; markets; milk fat; olein; palm kernel oil; peanut oil; rapid methods; screening; shea butter; sodium; spectroscopy; triolein
Abstract:
... This article reports the rapid screening and identification of the triacylglycerol content of shea butter fat, palm kernel oil, and peanut oil sold in the local Ghanaian market for their characterization and identification. Samples were dissolved in chloroform with 2,5-dihydroxybenzoic acid as the matrix. After subjecting the samples to matrix-assisted laser desorption ionization-time-of-flight/ma ...
DOI:
10.1080/10942912.2016.1155056

79. Development of a novel microextraction by packed sorbent-based approach followed by ultrahigh pressure liquid chromatography as a powerful technique for quantification phenolic constituents of biological interest in wines

Author:
João Gonçalves; Berta Mendes; Catarina L. Silva; José S. Câmara
Source:
Journal of chromatography 2012 v.1229 no. pp. 13-23
ISSN:
0021-9673
Subject:
2,5-dihydroxybenzoic acid; bioactive properties; ethanol; ferulic acid; formic acid; gallic acid; liquid chromatography; metabolites; methanol; microextraction; particle size; quantitative analysis; red wines; syringic acid; white wines
Abstract:
... A novel analytical approach, based on a miniaturized extraction technique, the microextraction by packed sorbent (MEPS), followed by ultrahigh pressure liquid chromatography (UHPLC) separation combined with a photodiode array (PDA) detection, has been developed and validated for the quantitative determination of sixteen biologically active phenolic constituents of wine. In addition to performing r ...
DOI:
10.1016/j.chroma.2012.01.023

80. Different inhibition mechanisms of gentisic acid and cyaniding-3-O-glucoside on polyphenoloxidase

Author:
Lei Zhou; Zhiqiang Xiong; Wei Liu; Liqiang Zou
Source:
Food chemistry 2017 v.234 pp. 445-454
ISSN:
0308-8146
Subject:
2,5-dihydroxybenzoic acid; active sites; catechol oxidase; fruits; grains; heat inactivation; hydrogen bonding; molecular models; mushrooms; polyphenols; spectral analysis; van der Waals forces
Abstract:
... Gentisic acid and cyanidin-3-O-glucoside are important bioactive polyphenols which are widely distributed in many fruits and cereals. In this work, kinetic study, spectral analysis and computational simulation were used to compare the inhibitory effects and inhibition mechanisms of gentisic acid and cyanidin-3-O-glucoside on mushroom polyphenoloxidase (PPO). The inhibitory effect of cyanidin-3-O-g ...
DOI:
10.1016/j.foodchem.2017.05.010

81. Disruption of the primary salicylic acid hydroxylases in rice enhances broad‐spectrum resistance against pathogens

Author:
Yanjun Zhang; Qilu Yu; Shilei Gao; Ningning Yu; Li Zhao; Jinbin Wang; Jiangzhe Zhao; Peng Huang; Linbo Yao; Mo Wang; Kewei Zhang
Source:
Plant, cell and environment 2022 v.45 no.7 pp. 2211-2225
ISSN:
0140-7791
Subject:
2,5-dihydroxybenzoic acid; Magnaporthe oryzae; Oryza sativa; Xanthomonas oryzae pv. oryzae; callose; environment; paddies; panicles; reactive oxygen species; rice; salicylic acid
Abstract:
... Salicylic acid (SA) is a crucial hormone involved in plant immunity. Rice (Oryza sativa) maintains high SA levels that are not induced by pathogens. However, the roles of SA in rice immunity and yield remain largely unknown. Here, we identified SA 5‐hydroxylases 1 (OsS5H1) and 2 (OsS5H2) as the primary enzymes engaged in catalysing SA to 2,5‐dihydroxybenzoic acid (2,5‐DHBA) in rice. SA levels were ...
DOI:
10.1111/pce.14328

82. Distribution study of atorvastatin and its metabolites in rat tissues using combined information from UHPLC/MS and MALDI-Orbitrap-MS imaging

Author:
Robert Jirásko; Michal Holčapek; Martin Kuneš; Aleš Svatoš
Source:
Analytical and bioanalytical chemistry 2014 v.406 no.19 pp. 4601-4610
ISSN:
1618-2642
Subject:
2,5-dihydroxybenzoic acid; blood serum; desorption; drugs; feces; glass; image analysis; ionization; ions; liver; metabolites; rats; spectrometers; stainless steel; sublimation; tandem mass spectrometry; tissues; ultra-performance liquid chromatography
Abstract:
... The combination of ultrahigh-resolution mass spectrometry imaging (UHRMSI) and ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC/MS/MS) was used for the identification and the spatial localization of atorvastatin (AT) and its metabolites in rat tissues. Ultrahigh-resolution and high mass accuracy measurements on a matrix-assisted laser desorption/ionization ( ...
DOI:
10.1007/s00216-014-7880-y

83. Dithranol as a MALDI Matrix for Tissue Imaging of Lipids by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Author:
Le Cuong H.; Han Jun; Borchers Christoph H.
Source:
Analytical chemistry 2012 v.84 no.19 pp. 8391-8398
ISSN:
1520-6882
Subject:
2,5-dihydroxybenzoic acid; acylglycerols; calves; ceramides; chloroform; cortex; formic acid; image analysis; liver; mass spectrometry; methanol; phosphates; phosphatidylcholines; phosphatidylethanolamines; phosphatidylserines; rats; sphingomyelins
Abstract:
... To fill the unmet need for improved matrixes for matrix-assisted laser desorption ionization (MALDI) tissue imaging of small molecules, dithranol (DT)a matrix mainly used for the analysis of synthetic polymerswas evaluated for detection of lipids in rat liver and bovine calf lens, using MALDI Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS). The use of DT resulted in better ...
DOI:
10.1021/ac301901s

84. Divergent Synthesis of Natural Benzyl Salicylate and Benzyl Gentisate Glucosides

Author:
Dariya D. Fedorova; Dariya S. Nazarova; David L. Avetyan; Andrey Shatskiy; Maxim L. Belyanin; Markus D. Kärkäs; Elena V. Stepanova
Source:
Journal of natural products 2020 v.83 no.10 pp. 3173-3180
ISSN:
1520-6025
Subject:
2,5-dihydroxybenzoic acid; Populus balsamifera; Salix; glucosides; metabolites; rare species; sugars
Abstract:
... Herein is reported the first total synthesis of benzyl salicylate and benzyl gentisate glucosides present in various plant species, in particular the Salix genus, such as Populus balsamifera and P. trichocarpa. The method permits the synthesis of several natural phenolic acid derivatives and their glucosides starting from salicylic or gentisic acid. The divergent approach afforded access to three ...
DOI:
10.1021/acs.jnatprod.0c00838

85. Do drought-adapted peanut genotypes have different bioactive compounds and ROS-scavenging activity?

Author:
Fernanda Francetto Juliano; Adna Prado Massarioli; Rosa Maria Lamuela-Raventos; José Fernando Rinaldi de Alvarenga; Liziane Maria de Lima; Roseane Cavalcanti dos Santos; Camila Furtunato da Silva; Severino Matias de Alencar
Source:
European food research & technology 2021 v.247 no.6 pp. 1369-1378
ISSN:
1438-2377
Subject:
2,5-dihydroxybenzoic acid; drought tolerance; fatty acid composition; food research; genotype; peanuts; polyphenols; technology; tocopherols; Senegal
Abstract:
... Peanuts are grown in both developed and developing countries, and their cultivation has been considerably expanded to semiarid and arid regions. In this study, we investigated the ROS-scavenging activity and bioactive composition of hydric stress-tolerant (BR1, Senegal 55,437, L7 Bege, F.M424B) and -susceptible peanut genotypes (LViPE-06, LGoPE-06 and Tatu). Peanut grains were examined for their f ...
DOI:
10.1007/s00217-021-03714-0

86. Doped silica nanoparticles for the detection of pharmaceutical terbinafine in latent fingerprints by mass spectrometry

Author:
Angelina Yimei Lim; John Seviour
Source:
Analytical methods 2012 v.4 no.7 pp. 1983-1988
ISSN:
1759-9679
Subject:
2,5-dihydroxybenzoic acid; desorption; drug therapy; drugs; excretion; image analysis; matrix-assisted laser desorption-ionization mass spectrometry; nanoparticles; patients; silica; soot
Abstract:
... A detailed study on terbinafine excretion in latent fingerprints of a patient prescribed with the medication was carried out for a period of 14 days. Latent fingerprints collected from the patient were dusted with a fingerprint developing agent consisting of magnetized carbon black doped silica nanoparticles and directly analyzed by surface assisted laser desorption ionization-time of flight-mass ...
DOI:
10.1039/c2ay25187f

87. Dual-polarity MALDI mass spectrometry and imaging of oil binders and fatty acids in artworks using cyanographene as a single matrix

Author:
Tanushree Dutta; Tomáš Steklý; Lukáš Kučera; Karel Lemr
Source:
Talanta 2022 v.242 pp. 123291
ISSN:
0039-9140
Subject:
2,5-dihydroxybenzoic acid; energy transfer; fatty acids; graphene; ionization; matrix-assisted laser desorption-ionization mass spectrometry; oils; oxidation; triacylglycerols
Abstract:
... Matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) and imaging mass spectrometry (IMS) are being increasingly recognized for the detection and visualization of various organic species including lipids and fatty acids. Nevertheless, most MALDI matrices perform optimally in one ionization mode. This study investigates the performance of cyano derivative of graphene (G-CN) as a ...
DOI:
10.1016/j.talanta.2022.123291

88. Effect of gentisic acid on the structural-functional properties of liposomes incorporating β-sitosterol

Author:
Aleksandra A. Jovanović; Bojana D. Balanč; Verica B. Djordjević; Ajda Ota; Mihaela Skrt; Katarina P. Šavikin; Branko M. Bugarski; Viktor A. Nedović; Nataša Poklar Ulrih
Source:
Colloids and surfaces 2019 v.183 pp. 110422
ISSN:
0927-7765
Subject:
2,5-dihydroxybenzoic acid; beta-sitosterol; cholates; encapsulation; enzymes; gastric juice; intestines; lipid peroxidation; membrane fluidity; pH; phosphatidylcholines
Abstract:
... Multifunctional liposomes incorporating β-sitosterol were developed for delivery of gentisic acid (GA). The interactions of both compounds with phospholipid bilayer were interpreted viaeffects of different β-sitosterol content (0, 20 and 50 mol %) and different gentisic acid to lipid ratio (nGA/nₗᵢₚ from 10⁻⁵ to 1) on membrane fluidity and thermotropic properties. Multilamellar vesicles of phospha ...
DOI:
10.1016/j.colsurfb.2019.110422

89. Effect of hydroxybenzoic acids antioxidants on the oxidative stability of sardine oil

Author:
Vaisali Chandrasekar; Prasanna D. Belur; I. Regupathi
Source:
Resource-efficient technologies 2016 v.2 pp. S114
ISSN:
2405-6537
Subject:
2,5-dihydroxybenzoic acid; antioxidant activity; antioxidants; benzoic acid; hydroxylation; lipids; oxidative stability; p-anisidine value; peroxide value; sardine oil; thiobarbituric acid-reactive substances; vanillic acid
Abstract:
... The antioxidant capacities of three derivatives of hydroxybenzoic acids (Gentisic acid, protochatechuic acid and vanillic acid) in sardine oil were compared. Peroxide value, conjugated diene value, p-anisidine value and thiobarbituric acid reactive substances (TBARS) value were assessed to determine the oxidative stability provided by these substances to the sardine oil. Results showed that gentis ...
DOI:
10.1016/j.reffit.2016.11.008

90. Effect of plant secondary metabolites on legume pod borer, Helicoverpa armigera

Author:
Abdul Rashid War; Michael Gabriel Paulraj; Barkat Hussain; Abdul Ahad Buhroo; Savarimuthu Ignacimuthu; Hari Chand Sharma
Source:
Journal of pest science 2013 v.86 no.3 pp. 399-408
ISSN:
1612-4758
Subject:
2,5-dihydroxybenzoic acid; Helicoverpa armigera; Maruca testulalis; artificial diets; caffeic acid; catechin; chlorogenic acid; cinnamic acid; concanavalin A; enzyme activity; ferulic acid; insect control; larvae; larval development; leaves; peanuts; protocatechuic acid; quercetin; secondary metabolites; serine proteinases; umbelliferones
Abstract:
... The effect of various flavonoids, lectins and phenyl β-D-glucoside on larval survival, weights and the activities of digestive (total serine protease and trypsin) and detoxifying [esterase and glutathione-S-transferase] enzymes of Helicoverpa armigera larvae at 5 and 10 days after treatment (DAT) was studied through diet incorporation assay. Flavonoids (quercetin, cinnamic acid, caffeic acid, chlo ...
DOI:
10.1007/s10340-013-0485-y

91. Effect of squalane-based emulsion on polyphenols skin penetration: Ex vivo skin study

Author:
Ana L.S. Oliveira; Diana Valente; Helena R. Moreira; Manuela Pintado; Patrícia Costa
Source:
Colloids and surfaces 2022 v.218 pp. 112779
ISSN:
0927-7765
Subject:
2,5-dihydroxybenzoic acid; anti-aging properties; emulsions; ferulic acid; models; p-coumaric acid; permeability; polyphenols; solubility
Abstract:
... Polyphenols have gained attractiveness as ingredients in cosmetic formulations as result of their ability to delay the aging process. However, different factors limit their use, including low solubility and poor skin permeability. In this sense, this study describes the potential of squalane to increase the polyphenols ex vivo skin penetration, incorporated into a water-in-oil emulsion. Polyphenol ...
DOI:
10.1016/j.colsurfb.2022.112779

92. Elderberry (Sambucus nigra L.) as potential source of antioxidants. Characterization, optimization of extraction parameters and bioactive properties

Author:
Rubén Domínguez; Leilei Zhang; Gabriele Rocchetti; Luigi Lucini; Mirian Pateiro; Paulo E.S. Munekata; José M. Lorenzo
Source:
Food chemistry 2020 v.330 pp. 127266
ISSN:
0308-8146
Subject:
2,5-dihydroxybenzoic acid; Sambucus nigra; anthocyanins; antioxidant activity; antioxidants; carotenoids; elderberries; ethanol; experimental design; gallic acid; nutritive value; pH; polyunsaturated fatty acids; proteins; quercetin; response surface methodology; rutin; temperature; total soluble solids
Abstract:
... The present study aimed to characterize the nutritional value and potential use of elderberries as a source of antioxidant compounds. The chemical composition, fatty acids and phenolic compounds were determined for elderberries. The optimization of extraction parameters was designed with a Box-Behnken design coupled with response surface methodology (RSM) and desirability function analysis. The pr ...
DOI:
10.1016/j.foodchem.2020.127266

93. Endophytic Alcaligenes faecalis mediated redesigning of host defense itinerary against Sclerotium rolfsii through induction of phenolics and antioxidant enzymes

Author:
Shatrupa Ray; Prashant Swapnil; Prachi Singh; Surendra Singh; Birinchi Kumar Sarma; Harikesh Bahadur Singh
Source:
Biological control 2020 v.150 pp. 104355
ISSN:
1049-9644
Subject:
2,5-dihydroxybenzoic acid; Alcaligenes faecalis; Athelia rolfsii; Sclerotium (genus); antioxidant enzymes; biological control; endophytes; ferulic acid; hosts; kaempferol; leaves; lignification; microorganisms; okra; peroxidase; quercetin; rutin; superoxide dismutase
Abstract:
... Endophytic microbes intricately modulate host defense pathways upon challenge with any form of environmental stress. In the current study, endophytic Alcaligenes faecalis treated okra plants were found to exhibit significant resistance to cell-lysis and disintegration upon infection with Sclerotium rolfsii. Apart from the morphological amendments, a systemic induction in phenolic content was obser ...
DOI:
10.1016/j.biocontrol.2020.104355

94. Enhanced Sensitivity for High Spatial Resolution Lipid Analysis by Negative Ion Mode Matrix Assisted Laser Desorption Ionization Imaging Mass Spectrometry

Author:
Angel Peggi M.; Spraggins Jeffrey M.; Baldwin H. Scott; Caprioli Richard
Source:
Analytical chemistry 2012 v.84 no.3 pp. 1557-1564
ISSN:
1520-6882
Subject:
2,5-dihydroxybenzoic acid; adults; ammonium acetate; brain; buffers; desorption; formates; gangliosides; glycerophosphates; image analysis; ionization; mass spectrometry; mice; pH; sublimation; washing
Abstract:
... We have achieved enhanced lipid imaging to a ∼10 μm spatial resolution using negative ion mode matrix assisted laser desorption ionization (MALDI) imaging mass spectrometry, sublimation of 2,5-dihydroxybenzoic acid as the MALDI matrix, and a sample preparation protocol that uses aqueous washes. We report on the effect of treating tissue sections by washing with volatile buffers at different pHs pr ...
DOI:
10.1021/ac202383m
PubMed:
22243218
PubMed Central:
PMC3277660

95. Enhancement of soluble dietary fibre, polyphenols and antioxidant properties of chapatis prepared from whole wheat flour dough treated with amylases and xylanase

Author:
Mysore S Hemalatha; Suresh G Bhagwat; Paramahans V Salimath; Ummiti JS Prasada Rao
Source:
Journal of the science of food and agriculture 2012 v.92 no.4 pp. 764-771
ISSN:
0022-5142
Subject:
2,5-dihydroxybenzoic acid; amylases; antioxidant activity; caffeic acid; carbohydrates; crosslinking; dough; enzymatic treatment; insoluble fiber; liquid chromatography; polyphenols; proteins; soluble fiber; wheat flour; xylanases
Abstract:
... BACKGROUND: Chapati preparation involves various processing steps such as mixing the flour into dough, sheeting and baking. During these processing steps, flour components are likely to undergo changes in their nutrient and polyphenol composition and their antioxidant properties due to phenol‐mediated crosslinking of proteins and carbohydrates. Therefore, in the present study, changes in nutrition ...
DOI:
10.1002/jsfa.4640
PubMed:
21953440

96. Establishment of Momordica charantia hairy root cultures for the production of phenolic compounds and determination of their biological activities

Author:
Muthu Thiruvengadam; Nagella Praveen; K. M. Maria John; Ye-Sul Yang; Seung-Hyun Kim; Ill-Min Chung
Source:
Plant cell, tissue, and organ culture 2014 v.118 no.3 pp. 545-557
ISSN:
0167-6857
Subject:
2,5-dihydroxybenzoic acid; Momordica charantia; antimicrobial properties; antioxidants; biomass production; catechin; chlorogenic acid; clones; cotyledons; culture media; explants; ferulic acid; gallic acid; hypocotyls; leaves; myricetin; naringenin; naringin; quercetin; reverse transcriptase polymerase chain reaction; roots; rutin; salicylic acid; secondary metabolites; seedlings; sucrose; traditional medicine; ultra-performance liquid chromatography; vegetable crops
Abstract:
... Momordica charantia is an important vegetable crop and is also used in traditional medicine. The production of secondary metabolites from hairy root cultures of Indian M. charantia (IMC) and Korean M. charantia (KMC) along with their biological activities (antioxidant and antimicrobial activities) were compared. The explants (leaves, cotyledons, hypocotyls, roots, and nodes) from in vitro seedling ...
DOI:
10.1007/s11240-014-0506-4

97. Estrogenic properties of Prunus cerasoides extract and its constituents in MCF‐7 cell and evaluation in estrogen‐deprived rodent models

Author:
So‐Dam Kim; Yeojin Kim; Mingee Kim; Hyesoo Jeong; Sang Ho Choi; Hyung Won Ryu; Sei‐Ryang Oh; Sang Woo Lee; Wan Yi Li; Hong‐Hua Wu; Yan Zhu; Xiaoying Wang; Minsun Chang; Yun Seon Song
Source:
Phytotherapy research 2020 v.34 no.6 pp. 1347-1357
ISSN:
0951-418X
Subject:
2,5-dihydroxybenzoic acid; Prunus cerasoides; animal models; assays; binding capacity; blood serum; cell proliferation; estrogen receptors; estrogenic properties; estrogens; extracts; females; flavones; gene expression; human cell lines; isoflavones; liver; mice; ovariectomy; phytotherapy; plant estrogens; postmenopause; rats; research; transcription (genetics); triacylglycerols
Abstract:
... Prunus cerasoides (PC) products contain relatively high levels of flavones and isoflavones and may be potential sources of phytoestrogens for postmenopausal symptom relief. We assessed the PC extract (PCE) and its representative constituents in vitro with assays for estrogen receptor alpha binding, estrogen response element transcriptional activity, cell proliferation, and gene expression changes ...
DOI:
10.1002/ptr.6604

98. Evaluation and optimization of the influence of silver cluster ions on the MALDI-TOF-MS analysis of polystyrene nanoplastic polymers

Author:
Théogène Habumugisha; Zixing Zhang; Jean Claude Ndayishimiye; François Nkinahamira; Alexis Kayiranga; Eric Cyubahiro; Abdul Rehman; Changzhou Yan; Xian Zhang
Source:
Analytical methods 2022 v.14 no.7 pp. 763-772
ISSN:
1759-9679
Subject:
2,5-dihydroxybenzoic acid; anthracenes; benzoic acid; cationization; chlorides; desorption; nanoplastics; polystyrenes; silver; silver nitrate; sinapic acid
Abstract:
... In the analysis of polystyrene nanoplastics (PSNs), a nonpolar polymer (NP), using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), silver salts were used as cationization reagents and simultaneously brought the potential problems of silver clusters that interfered with the PSN signal of MS. To detect PSNs, silver trifluoroacetate (AgTFA) and silver nitr ...
DOI:
10.1039/d1ay02219a

99. Evaluation of antioxidant supplementation in must on the development and potential reduction of different compounds involved in atypical ageing of wine using HPLC-HRMS

Author:
Tiziana Nardin; Tomas Roman; Susanne Dekker; Giorgio Nicolini; Francesco Thei; Barbara Masina; Roberto Larcher
Source:
Lebensmittel-Wissenschaft + Technologie 2022 v.154 pp. 112639
ISSN:
0023-6438
Subject:
2,5-dihydroxybenzoic acid; adjuvants; analysis of covariance; antioxidants; ascorbic acid; ellagic acid; fermentation; gallic acid; glutathione; grapes; mass spectrometry; metabolites; models; off flavors
Abstract:
... Atypical aging of white wines (ATA) is an off-flavour characterised by rapid loss of fruity aromas and the development of unpleasant odours. This study aims to evaluate the effectiveness of different oenological adjuvants (4-ethylcatechol, 4-methylcatechol, gentisic acid, hydroxytyrosol, ascorbic acid, glutathione, ellagic acid, gallic acid, galla tannin, ellagic tannin, quebracho, grape tannins) ...
DOI:
10.1016/j.lwt.2021.112639

100. Evaluation of free hydroxyl radical scavenging activities of some Chinese herbs by capillary zone electrophoresis with amperometric detection

Author:
Hui Li; Qingjiang Wang
Source:
Analytical and bioanalytical chemistry 2004 v.378 no.7 pp. 1801-1805
ISSN:
1618-2642
Subject:
2,5-dihydroxybenzoic acid; Ligusticum; Ligustrum lucidum; capillary zone electrophoresis; detection limit; free radical scavengers; herbs; hydroxyl radicals; salicylic acid
Abstract:
... Due to the severe damage caused by free hydroxyl radicals (OH·) to cells and tissues, there is much interest in finding and studying effective and non-toxic OH· scavengers, including traditional Chinese herbs. In this paper, the simple and highly-sensitive technique of capillary zone electrophoresis with amperometric detection (CZE-AD) was used to study the OH· scavenging activities of aqueous ext ...
DOI:
10.1007/s00216-004-2509-1