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You searched for: Subject Alzheimer disease Remove constraint Subject: Alzheimer disease Subject acetylcholinesterase Remove constraint Subject: acetylcholinesterase
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1. Alzheimaretto

Source:
Journal of medicinal food 1998 v.1 no.1 pp. 53-56
ISSN:
1096-620X
Subject:
chemical composition; Alzheimer disease; anti-inflammatory activity; acetylcholinesterase; sage; free radicals; acetylcholine; medicinal plants; enzyme inhibitors; rosemary; oxidation; recipes; chemical constituents of plants; metabolites
DOI:
10.1089/jmf.1998.1.53

2. The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from Narcissus 'Sir Winston Churchill'

Author:
Ingkaninan, K.; Hazekamp, A.; Best, C.M. de.; Irth, H.; Tjaden, U.R.; Heijden, R. van der.; Greef, J. van der.; Verpoorte, R.
Source:
Journal of natural products 2000 v.63 no.6 pp. 803-806
ISSN:
0163-3864
Subject:
Narcissus; bulbs; alkaloids; spectral analysis; chemical structure; enzyme inhibitors; acetylcholinesterase; medicinal properties; Alzheimer disease; chemical constituents of plants
DOI:
10.1021/np9905719
PubMed:
10869205

3. Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and Alzheimer's disease brain

Author:
Z. Rakonczay
Source:
Acta biologica Hungarica 2003 v.54 no.2 pp. 183-189
ISSN:
0236-5383
Subject:
Alzheimer disease; acetylcholinesterase; cerebral cortex; cholinesterase; cortex; humans
Abstract:
... Eight inhibitors of acetylcholinesterase (AChE), tacrine, bis-tacrine, donepezil, rivastigmine, galantamine, heptyl-physostigmine, TAK-147 and metrifonate, were compared with regard to their effects on AChE and butyrylcholinesterase (BuChE) in normal human brain cortex. Additionally, the IC50 values of different molecular forms of AChE (monomeric, G1, and tetrameric, G4) were ...
DOI:
10.1556/ABiol.54.2003.2.7

4. Butyryl- and acetyl-cholinesterase inhibitory activities in essential oils of Salvia species and their constituents

Author:
Savelev, S.U.; Okello, E.J.; Perry, E.K.
Source:
Phytotherapy research 2004 v.18 no.4 pp. 315-324
ISSN:
0951-418X
Subject:
Alzheimer disease; acetylcholinesterase; essential oils; medicinal plants; cholinesterase inhibitors; Salvia officinalis; enzyme inhibition
DOI:
10.1002/ptr.1451
PubMed:
15162368

5. Coumarins from Peucedanum ostruthium as inhibitors of acetylcholinesterase

Author:
Urbain, A.; Marston, A.; Hostettmann, K.
Source:
Pharmaceutical biology 2005 v.43 no.8 pp. 647-650
ISSN:
1388-0209
Subject:
Peucedanum; medicinal plants; traditional medicine; perennials; herbs; roots; plant extracts; polyphenols; flavanoids; acetylcholinesterase; cholinesterase inhibitors; enzyme inhibition; structure-activity relationships; Alzheimer disease; disease prevention; Switzerland
DOI:
10.1080/13880200500382720

6. Mutant presenilin 2 increases acetylcholinesterase activity in neuronal cells

Author:
Hong Nga Nguyen; Dae Youn Hwang; Young Kyu Kim; Do Young Yoon; Jae Hwa Kim; Moon Soon Lee; Myung Koo Lee; Yeo Pyo Yun; Ki Wan Oh; Jin Tae Hong
Source:
Archives of pharmacal research 2005 v.28 no.9 pp. 1073-1078
ISSN:
0253-6269
Subject:
Alzheimer disease; acetylcholinesterase; enzyme activity; hydrogen peroxide; memory; mice; mutants; mutation; neurodegenerative diseases; neurons; transgenic animals
Abstract:
... A presenilin 2 mutation is believed to be involved in the development of Alzheimer's disease. In addition, transgenic mice with a presenilin 2 mutation have been reported to have learning and memory impairments. In this study, exposing PC12 cells expressing mutant presenilin 2 to 50 μM Aß₂₅–₃₅, 30 mML-glutamate and 50 μM H₂O₂ caused a significant increase in acetylcholine esterase activity. Anin v ...
DOI:
10.1007/BF02977404

7. Cholinergic basis of memory-strengthening effect of Foeniculum vulgare Linn

Author:
Joshi, H.; Parle, M.
Source:
Journal of medicinal food 2006 v.9 no.3 pp. 413-417
ISSN:
1096-620X
Subject:
mice; animal models; fennel; Foeniculum vulgare; specialty crops; medicinal properties; memory; cognition; cholinesterase; cholinesterase inhibitors; scopolamine; animal age; Alzheimer disease; acetylcholinesterase
DOI:
10.1089/jmf.2006.9.413
PubMed:
17004908

8. Acetylcholinesterase inhibitory-active components of Rhodiola rosea L

Author:
Wang, H.; Zhou, G.; Gao, X.; Wang, Y.; Yao, W.
Source:
Food chemistry 2007 v.105 no.1 pp. 24-27
ISSN:
0308-8146
Subject:
acetylcholinesterase; enzyme inhibition; Rhodiola rosea; rhizomes; plant extracts; hydroquinone; chemical constituents of plants; Alzheimer disease
Abstract:
... An activity-directed fractionation and purification process was used to identify the acetylcholinesterase inhibitory-active components of Rhodiola rosea L. (RR). Dried rhizome of RR was extracted with boiled ethanol. After removal of tannins, the extract was separated into chloroform, ethyl acetate, n-butanol and water fractions. Among these, chloroform and n-butanol fractions showed stronger acti ...
DOI:
10.1016/j.foodchem.2007.03.031

9. Benzylphenethylamine Alkaloids from Hosta plantaginea with Inhibitory Activity against Tobacco Mosaic Virus and Acetylcholinesterase

Author:
Wang, Y.H.; Zhang, Z.K.; Yang, F.M.; Sun, Q.Y.; He, H.P.; Di, Y.T.; Mu, S.Z.; Lu, Y.; Chang, Y.; Zheng, Q.T.
Source:
Journal of natural products 2007 v.70 no.9 pp. 1458-1461
ISSN:
0163-3864
Subject:
Hosta; Liliaceae; medicinal plants; phytochemicals; alkaloids; chemical structure; spectral analysis; stereochemistry; antiviral properties; Tobacco mosaic virus; plant viruses; acetylcholinesterase; enzyme inhibition; human health; Alzheimer disease; China
DOI:
10.1021/np0702077
PubMed:
17822295

10. Hairy root and tissue cultures of Leucojum aestivum L.--relationships to galanthamine content

Author:
Diop, M. F.; Hehn, A.; Ptak, A.; Chrétien, F.; Doerper, S.; Gontier, E.; Bourgaud, F.; Henry, M.; Chapleur, Y.; Laurain-Mattar, D.
Source:
Phytochemistry reviews 2007 v.6 no.1 pp. 137-141
ISSN:
1568-7767
Subject:
Alzheimer disease; Leucojum aestivum; Rhizobium rhizogenes; acetylcholinesterase; alkaloids; cell differentiation; growth regulators; metabolites; morphogenesis; roots; tissue culture
Abstract:
... Galanthamine, an isoquinoline alkaloid acetylcholinesterase inhibitor, is an important agent used all around the world for the symptomatic treatment of senile dementia of the Alzheimer's type. The production of this metabolite and the availability of the plant are limited and prompted the search for an alternative way to obtain this valuable metabolite using in vitro cultures of Leucojum aestivum ...
DOI:
10.1007/s11101-006-9043-z

11. Multiwell fluorometric and colorimetric microassays for the evaluation of beta-secretase (BACE-1) inhibitors

Author:
Mancini, Francesca; Naldi, Marina; Cavrini, Vanni; Andrisano, Vincenza
Source:
Analytical and bioanalytical chemistry 2007 v.388 no.5-6 pp. 1175-1183
ISSN:
1618-2642
Subject:
Alzheimer disease; absorbance; acetylcholinesterase; amyloid; casein; catalytic activity; colorimetry; drugs; enantiomers; etiology; fluorescein; fluorescence; fluorometry; hydrolysis; mutants; mutation; pH; proteinases; proteolysis; screening; toxicity
Abstract:
... The amyloid beta (Abeta) peptide is responsible for toxic amyloid plaque formation and is central to the aetiology of Alzheimer's disease (AD). It is generated by proteolytic processing of the amyloid precursor protein (APP) by beta-secretase (BACE-1) and gamma-secretase. Consequently, inhibition of BACE-1, a rate-limiting enzyme in the production of Abeta, is an attractive therapeutic approach to ...
DOI:
10.1007/s00216-007-1356-2

12. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity

Author:
Mukherjee, Pulok K.; Kumar, Venkatesan; Houghton, Peter J.
Source:
Phytotherapy research 2007 v.21 no.12 pp. 1142-1145
ISSN:
0951-418X
Subject:
Alzheimer disease; Andrographis paniculata; Centella asiatica; Myristica fragrans; Nelumbo nucifera; Valeriana jatamansi; acetylcholinesterase; adverse effects; erythrocytes; herbs; medicinal plants; medicine; patients; physostigmine; screening; therapeutics
Abstract:
... The cholinergic hypothesis of Alzheimer's disease (AD) has provided the rationale for the current pharmaco-therapy of this disease, in an attempt to reduce the cognitive decline caused by cholinergic deficits. Nevertheless, the search for potent and long-acting acetylcholinesterase (AChE) inhibitors that exert minimal side effects in AD patients is still ongoing. AChE inhibitors are currently the ...
DOI:
10.1002/ptr.2224
PubMed:
17639556

13. Tabernaemontana divaricata extract inhibits neuronal acetylcholinesterase activity in rats

Author:
Chattipakorn, S.; Pongpanparadorn, A.; Pratchayasakul, W.; Pongchaidacha, A.; Ingkaninan, K.; Chattipakorn, N.
Source:
Journal of ethnopharmacology 2007 v.110 no.1 pp. 61-68
ISSN:
0378-8741
Subject:
Tabernaemontana divaricata; medicinal plants; chemical constituents of plants; plant extracts; medicinal properties; bioassays; rats; Alzheimer disease; acetylcholinesterase; enzyme inhibitors; neurons; cerebral cortex
Abstract:
... The current pharmacotherapy for Alzheimer's disease (AD) is the use of acetylcholinesterase inhibitors (AChE-Is). A previous in vitro study showed that Tabernaemontana divaricata extract (TDE) can inhibit AChE activity. However, neither the AChE inhibitory effects nor the effect on neuronal activity of TDE has been investigated in vivo. To determine those effects of TDE in animal models, the Ellma ...
DOI:
10.1016/j.jep.2006.09.007

14. Acetyl- and butyrylcholinesterase inhibitory activities of sterols and phlorotannins from Ecklonia stolonifera

Author:
YOON, Na Y.; CHUNG, Hae Y.; KIM, Hyeung R.; CHOI, Jae S.
Source:
Fisheries science 2008 v.74 no.1 pp. 200-207
ISSN:
0919-9268
Subject:
Alzheimer disease; Ecklonia; acetylcholinesterase; cholinesterase; cholinesterase inhibitors; ethyl acetate; fractionation; hexane; inhibitory concentration 50; macroalgae; sterols
Abstract:
... As part of this study on the isolation of cholinesterase inhibitors from natural marine products, the bioactivity of the ethanolic extracts from 27 Korean seaweeds were screened using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory assays. Ecklonia stolonifera exhibited promising inhibitory properties against both AChE and BChE. Bioassay-guided fractionation of the active n ...
DOI:
10.1111/j.1444-2906.2007.01511.x

15. Amyloid-cholinesterase interactions

Author:
Inestrosa, Nibaldo C.; Dinamarca, Margarita C.; Alvarez, Alejandra
Source:
FEBS journal 2008 v.275 no.4 pp. 625-632
ISSN:
1742-464X
Subject:
Alzheimer disease; acetylcholinesterase; amyloid; neurotoxicity; prions
Abstract:
... Acetylcholinesterase is an enzyme associated with senile plaques. Biochemical studies have indicated that acetylcholinesterase induces amyloid fibril formation by interaction throughout the peripherical anionic site of the enzyme forming highly toxic acetylcholinesterase-amyloid-β peptide (Aβ) complexes. The pro-aggregating acetylcholinesterase effect is associated with the intrinsic amyloidogenic ...
DOI:
10.1111/j.1742-4658.2007.06238.x

16. In vitro production of huperzine A, a promising drug candidate for Alzheimer's disease

Author:
Ma, X.; Gang, D.R.
Source:
Phytochemistry 2008 v.69 no.10 pp. 2022-2028
ISSN:
0031-9422
Subject:
Huperzia; medicinal plants; micropropagation; callus culture; Oriental traditional medicine; phytochemicals; sesquiterpenoids; cholinesterase inhibitors; acetylcholinesterase; Alzheimer disease; disease control; human health
Abstract:
... Alzheimer's disease (AD) is growing in impact on human health. With no known cure, AD is one of the most expensive diseases in the world to treat. Huperzine A (HupA), a anti-AD drug candidate from the traditional Chinese medicine Qian Ceng Ta (Huperzia serrata), has been shown to be a powerful and selective inhibitor of acetylcholinesterase and has attracted widespread attention because of its uni ...
DOI:
10.1016/j.phytochem.2008.04.017
PubMed:
18538805

17. Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture

Author:
Limpeanchob, Nanteetip; Jaipan, Somkiet; Rattanakaruna, Saisunee; Phrompittayarat, Watoo; Ingkaninan, Kornkanok
Source:
Journal of ethnopharmacology 2008 v.120 no.1 pp. 112-117
ISSN:
0378-8741
Subject:
neuroprotective effect; memory; neurotoxicity; mechanism of action; cell death; acetylcholinesterase; neurons; oxidative stress; Alzheimer disease; animal proteins; lipid peroxidation; medicinal plants; plant extracts; antioxidant activity; cell lines; enzyme activity; herbal medicines; Bacopa monnieri
Abstract:
... Aim of the study: Bacopa monnieri (Brahmi) is extensively used in traditional Indian medicine as a nerve tonic and thought to improve memory. To examine the neuroprotective effects of Brahmi extract, we tested its protection against the beta-amyloid protein (25-35) and glutamate-induced neurotoxicity in primary cortical cultured neurons. Materials and Methods: Neuroprotective effects were determin ...
DOI:
10.1016/j.jep.2008.07.039
PubMed:
18755259

18. Non-hydrolytic functions of acetylcholinesterase

Author:
Greenfield, Susan A.; Zimmermann, Martina; Bond, Cherie E.
Source:
FEBS journal 2008 v.275 no.4 pp. 604-611
ISSN:
1742-464X
Subject:
Alzheimer disease; acetylcholinesterase; brain; neurodegenerative diseases; neurons
Abstract:
... This review explores the possibility that acetylcholinesterase may play a pivotal, non-hydrolytic role in neurodegeneration. More specifically, C-terminal sequences of acetylcholinesterase may act as signalling molecules in key brain regions characteristically vulnerable to Alzheimer's, Parkinson's and motor neuron disease. ...
DOI:
10.1111/j.1742-4658.2007.06235.x

19. Sensitive analysis of donepezil in plasma by capillary electrophoresis combining on-column field-amplified sample stacking and its application in Alzheimer's disease

Author:
Yeh, Hsin-Hua; Yang, Yuan-Han; Ko, Ju-Yun; Chen, Su-Hwei
Source:
Electrophoresis 2008 v.29 no.17 pp. 3649-3657
ISSN:
0173-0835
Subject:
Alzheimer disease; acetylcholinesterase; detection limit; coatings; humans; pharmacokinetics; liquid-liquid extraction; cations; capillary electrophoresis; pH; polyvinyl alcohol; patients; sodium; oral administration; blood; females
Abstract:
... Field-amplified sample stacking (FASS) in capillary electrophoresis (CE) was used to determine the concentration of donepezil, an acetylcholinesterase inhibitor, in human plasma. A sample pretreatment by liquid-liquid extraction with isopropanol/n-hexane (v/v 3:97) and subsequent quantification by FASS-CE was used. Before sample loading, a water plug (0.5 psi, 6 s) was injected to permit FASS. Ele ...
DOI:
10.1002/elps.200800276

20. Anticholinesterase activity of 7-methoxyflavones isolated from Kaempferia parviflora

Author:
Sawasdee, Pattara; Sabphon, Chalisa; Sitthiwongwanit, Duangporn; Kokpol, Udom
Source:
Phytotherapy research 2009 v.23 no.12 pp. 1792-1794
ISSN:
0951-418X
Subject:
Alzheimer disease; Kaempferia; acetylcholinesterase; cholinesterase; flavones; nuclear magnetic resonance spectroscopy; plant extracts; rhizomes; screening; structure-activity relationships; traditional medicine
Abstract:
... The rhizome of Kaempferia parviflora or kra-chai-dum (in Thai) is used traditionally as a folk medicine. The preliminary cholinesterase inhibitory screening of this plant extract exhibited significant acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. Thirteen known methoxyflavones (1-13) were isolated and their structures were completely elucidated based on NMR an ...
DOI:
10.1002/ptr.2858
PubMed:
19548291

21. Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants

Author:
Orhan, Ilkay; Aslan, Mustafa
Source:
Journal of ethnopharmacology 2009 v.122 no.2 pp. 327-332
ISSN:
0378-8741
Subject:
traditional medicine; memory; Alzheimer disease; acetylcholinesterase; dose response; Melissa officinalis; Salvia; scopolamine; medicinal plants; plant extracts; avoidance conditioning; in vitro studies; medicinal properties; antioxidant activity; enzyme inhibition; Teucrium polium; Turkey (country)
Abstract:
... Ethnopharmacological relevance: Salvia species and Melissa officinalis are used for their memory-enhancing effects in European folk medicine. Teucrium polium was reported to be used in Anatolia for memory-enhancement in a very old book written by an Ottoman herbalist-physician. Aim of the study: Alzheimer's disease (AD) is a progressive neurological disorder mostly affecting the elder population. ...
DOI:
10.1016/j.jep.2008.12.026
PubMed:
19162154

22. Aqueous extracts of FBD, a Chinese herb formula composed of Poria cocos, Atractylodes macrocephala, and Angelica sinensis reverse scopolamine induced memory deficit in ICR mice

Author:
Lin, Zhihong; Xiao, Zhibin; Zhu, Danni; Yan, Yongqing; Yu, Boyang; Wang, Qiujuan
Source:
Pharmaceutical biology 2009 v.47 no.5 pp. 396-401
ISSN:
1388-0209
Subject:
Oriental traditional medicine; herbal medicines; medicinal plants; medicinal properties; mice; memory; Poria; Atractylodes; Angelica sinensis; scopolamine; plant extracts; roots; males; avoidance conditioning; acetylcholinesterase; cholinesterase inhibitors; enzyme activity; hippocampus; acute toxicity; Alzheimer disease; in vivo studies; in vitro studies; China
DOI:
10.1080/13880200902758816

23. Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brain

Author:
Lauren Meredith Willis; Barbara Shukitt-Hale; James A. Joseph
Source:
Genes & nutrition 2009 v.4 no.4 pp. 309
ISSN:
1555-8932
Subject:
Alzheimer disease; acetylcholine; acetylcholinesterase; animals; cortex; dietary supplements; enzyme inhibition; hippocampus; hydrolysis; neurons; polyunsaturated fatty acids
Abstract:
... The cholinergic theory of aging states that dysfunction of cholinergic neurons arising from the basal forebrain and terminating in the cortex and hippocampus may be involved in the cognitive decline that occurs during aging and Alzheimer’s disease. Despite years of research, pharmacological interventions to treat or forestall the development of Alzheimer’s disease have primarily focused on enhanci ...
DOI:
10.1007/s12263-009-0141-6
PubMed:
19727886
PubMed Central:
PMC2775891

24. KD-501, a standardized extract of Scrophularia buergeriana has both cognitive-enhancing and antioxidant activities in mice given scopolamine

Author:
Jeong, Eun Ju; Ma, Choong Je; Lee, Ki Yong; Kim, Seung Hyun; Sung, Sang Hyun; Kim, Young Choong
Source:
Journal of ethnopharmacology 2009 v.121 no.1 pp. 98-105
ISSN:
0378-8741
Subject:
Alzheimer disease; acetylcholinesterase; glutathione-disulfide reductase; scopolamine; superoxide dismutase; plant extracts; Scrophularia; mice; hippocampus; cholinesterase inhibitors; cognition; antioxidant activity; oral administration; roots; animal disease models; South Korea
Abstract:
... Aim of the study: The cognitive-enhancing and antioxidant activities of KD-501, a standardized extract of the roots of Scrophularia buergeriana Miquel (Scrophulariceae) were investigated. Materials and methods: KD-501 was orally administered to amnesic mice induced by scopolamine and we performed passive avoidance and the Morris water maze tests. To elucidate the mechanism of cognitive-enhancing a ...
DOI:
10.1016/j.jep.2008.10.006

25. Simultaneous determination of galantamine, rivastigmine and NAP 226-90 in plasma by MEKC and its application in Alzheimer's disease

Author:
Hsieh, Ya-Hui; Yang, Yuan-Han; Yeh, Hsin-Hua; Lin, Ping-Chih; Chen, Su-Hwei
Source:
Electrophoresis 2009 v.30 no.4 pp. 644-653
ISSN:
0173-0835
Subject:
Alzheimer disease; acetylcholinesterase; blood; drugs; electrophoresis; liquid-liquid extraction; males; metabolites; micellar electrokinetic capillary chromatography; monitoring; oral administration; pH; patients; sodium; wavelengths
Abstract:
... A simple and sensitive MEKC with UV detection was developed and validated for the simultaneous determination of acetylcholinesterase inhibitors including galantamine, rivastigmine and major metabolite NAP 226-90 in plasma. A sample pretreatment by liquid-liquid extraction with diethylether and subsequent quantification by MEKC was used. The optimum separation for these analytes was achieved in <10 ...
DOI:
10.1002/elps.200800559

26. Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task

Author:
Wong, Kelvin Kin-Kwan; Ho, Michelle Tsz-Wan; Lin, Huang Quan; Lau, Kwok-Fau; Rudd, John A.; Chung, Ronald Chi-Kit; Fung, Kwok-Pui; Shaw, Pang-Chui; Wan, David Chi-Cheong
Source:
Planta medica 2010 v.76 no.3 pp. 228-234
ISSN:
0032-0943
Subject:
Salvia miltiorrhiza; medicinal plants; roots; chemical constituents of plants; diterpenoids; plant extracts; medicinal properties; Alzheimer disease; memory; disease prevention; acetylcholinesterase; enzyme inhibitors; animal models; rats
DOI:
10.1055/s-0029-1186084
PubMed:
19774505

27. Enzymatic production of bioactive protein hydrolysates from tuna liver: effects of enzymes and molecular weight on bioactivity

Author:
Ahn, Chang-Bum; Lee, Ka-Hwa; Je, Jae-Young
Source:
International journal of food science & technology 2010 v.45 no.3 pp. 562-568
ISSN:
0950-5423
Subject:
Alzheimer disease; DNA damage; acetylcholinesterase; antioxidant activity; bioassays; enzymatic hydrolysis; feeds; fish meal; hydrogen peroxide; hydrolysates; hydrolysis; hydroxyl radicals; liver; liver protein; meat and bone meal; molecular weight; peptides; plasmids; protein hydrolysates; subtilisin; tuna; ultrafiltration
Abstract:
... Tuna liver is fish by-product, which is normally discarded and/or used as fish meal and animal feed because of poor functionality. In this study, we attempt to recover functional peptides from tuna liver protein by enzymatic hydrolysis using various proteases, and further hydrolysates were fractionated into four categories base on their molecular weight (MW) by ultrafiltration membranes. All fract ...
DOI:
10.1111/j.1365-2621.2009.02166.x

28. Survey of 55 Turkish Salvia taxa for their acetylcholinesterase inhibitory and antioxidant activities

Author:
Şenol, F. Sezer; Orhan, Ilkay; Celep, Ferhat; Kahraman, Ahmet; Doğan, Musa; Yilmaz, Gülderen; Şener, Bilge
Source:
Food chemistry 2010 v.120 no.1 pp. 34-43
ISSN:
0308-8146
Subject:
Salvia; acetylcholinesterase; enzyme inhibition; enzyme inhibitors; antioxidant activity; free radical scavengers; phytochemicals; medicinal plants; plant extracts; Alzheimer disease; Turkey (country)
Abstract:
... In the current work, our target was to screen inhibitory potentials of 55 Turkish Salvia taxa, 28 of which are endemic, against acetylcholinesterase (AChE), which is a chief enzyme in pathogenesis of Alzheimer's disease (AD). The dichloromethane, ethyl acetate, and methanol extracts prepared from 55 Salvia taxa were tested for their AChE inhibitory activity at 25, 50, and 100μg/ml using an ELISA m ...
DOI:
10.1016/j.foodchem.2009.09.066

29. Triterpenoids with acetylcholin-esterase inhibition from Chuquiraga erinacea D. Don. subsp. erinacea (Asteraceae)

Author:
Vela Gurovic, Maria Soledad; Castro, Maria Julia; Richmond, Victoria; Faraoni, Maria Belen; Maier, Marta S.; Murray, Ana Paula
Source:
Planta medica 2010 v.76 no.6 pp. 607-610
ISSN:
0032-0943
Subject:
Chuquiraga; medicinal plants; leaves; chemical constituents of plants; triterpenoids; plant extracts; medicinal properties; Alzheimer disease; acetylcholinesterase; enzyme inhibitors; Argentina
DOI:
10.1055/s-0029-1240582
PubMed:
19918718

30. The butanol fraction of Eclipta prostrata (Linn) increases the formation of brain acetylcholine and decreases oxidative stress in the brain and serum of cesarean-derived rats

Author:
Kim, Dae-Ik; Lee, Sung-Hyen; Hong, Joo-Heon; Lillehoj, Hyun Soon; Park, Hong-Ju; Rhie, Seung-Gyo; Lee, Gun-Soon
Source:
Nutrition research 2010 v.30 no.8 pp. 579-584
ISSN:
0271-5317
Subject:
memory; medicinal plants; plant extracts; cesarean section; oxidative stress; acetylcholinesterase; acetylcholine; brain; neurotransmitters; cognition; blood serum; superoxide dismutase; rats; amine oxidase (flavin-containing); Eclipta prostrata; antioxidant activity; enzyme activity; neuroprotective effect; Alzheimer disease; free radical scavengers; animal models
Abstract:
... Eclipta prostrata has been used as a traditional medicinal plant to prevent dementia and to enhance memory in Asia. Its potential as a nootropic and as an antioxidant have been reported in mice. We hypothesized that Eclipta may affect the formation of neurotransmitters and the inhibition of oxidative stress. Charles River cesarean-derived rats (male, 180 ± 10 g) were fed experimental diets supplem ...
Handle:
10113/45640
DOI:
10.1016/j.nutres.2010.08.001
PubMed:
20851313

31. Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids?

Author:
Rita Romani; Roberta Galeazzi; Gabriella Rosi; Rosamaria Fiorini; Irene Pirisinu; Annarina Ambrosini; Giovanna Zolese
Source:
Biochimie 2011 v.93 no.9 pp. 1584-1591
ISSN:
0300-9084
Subject:
Alzheimer disease; X-ray diffraction; acetylcholinesterase; anti-inflammatory activity; blood serum; brain; humans; molecular models; tissues
Abstract:
... Butyrylcholinesterase (BChE), a serine hydrolase biochemically related to the cholinergic enzyme Acetylcholinesterase (AChE), is found in many mammalian tissues, such as serum and central nervous system, but its physiological role is still unclear. BChE is an important human plasma esterase, where it has detoxifying roles. Furthermore, recent studies suggest that brain BChE can have a role in Alzh ...
DOI:
10.1016/j.biochi.2011.05.024

32. Antioxidant and acetylcholinesterase inhibitory activity of selected southern African medicinal plants

Author:
E.A. Adewusi; N. Moodley; V. Steenkamp
Source:
South African journal of botany 2011 v.77 no.3 pp. 638-644
ISSN:
0254-6299
Subject:
Alzheimer disease; Buddleja; Chamaecrista; Salvia; Schotia; acetylcholinesterase; antioxidant activity; antioxidants; bark; brain; disease control; drugs; medicinal plants; roots; secondary metabolites
Abstract:
... Alzheimer's disease (AD) is the most common type of dementia in the aging population. Enhancement of acetylcholine levels in the brain is one means of treating the disease. However, the drugs presently used in the management of the disease have various drawbacks. New treatments are required and in this study, extracts of Salvia tiliifolia Vahl. (whole plant), Chamaecrista mimosoides L. Greene (roo ...
DOI:
10.1016/j.sajb.2010.12.009

33. Determination of total phenol content, antioxidant activity and acetylcholinesterase inhibition in selected mushrooms from Turkey

Author:
Ilkay Orhan; Osman Üstün
Source:
Journal of food composition and analysis 2011 v.24 no.3 pp. 386-390
ISSN:
0889-1575
Subject:
Alzheimer disease; Cantharellus cibarius; Coriolus versicolor; Lactarius deliciosus; Laetiporus sulphureus; Polyporus; acetylcholinesterase; antioxidant activity; enzyme-linked immunosorbent assay; free radical scavengers; mushroom growing; mushrooms; phenol; Turkey (country)
Abstract:
... In the present study, we investigated the acetylcholinesterase (AChE) inhibitory activity of the ethanolic extracts of a number of mushroom species growing in Turkey, including mainly Polyporus species (Polyporus gilvus, Polyporus sulphureus, Polyporus annosus, Polyporus radiatus, Polyporus pinicola, Polyporus volvatus, Polyporus fomentarius, Polyporus stevenii, Polyporus badius), as well as Canth ...
DOI:
10.1016/j.jfca.2010.11.005

34. Development and validation of a GC–MS method for rapid determination of galanthamine in Leucojum aestivum and Narcissus ssp.: A metabolomic approach

Author:
Strahil Berkov; Jaume Bastida; Francesc Viladomat; Carles Codina
Source:
Talanta 2011 v.83 no.5 pp. 1455-1465
ISSN:
0039-9140
Subject:
Alzheimer disease; Leucojum aestivum; Narcissus; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; high performance liquid chromatography; leaves; metabolomics; methanol; nuclear magnetic resonance spectroscopy; pharmaceutical industry; principal component analysis; quality control; rapid methods; raw materials
Abstract:
... Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt for the treatment of Alzheimer's disease, is obtained from some Amaryllidaceae plants. A new method was developed and validated for its quantification by GC–MS in different plant sources: bulbs and leaves from Narcissus confusus; bulbs from N. pseudonarcissus cv. Carlton; and leaves and in vitro cultures from L. aestiv ...
DOI:
10.1016/j.talanta.2010.11.029

35. Estimation of neuroprotective effects of Laurocerasus officinalis Roem. (cherry laurel) by in vitro methods

Author:
Ilkay Erdogan Orhan; Esra Küpeli Akkol
Source:
Food research international 2011 v.44 no.3 pp. 818-822
ISSN:
0963-9969
Subject:
Alzheimer disease; Prunus laurocerasus; acetates; acetone; acetylcholinesterase; antioxidant activity; cholinesterase; enzyme-linked immunosorbent assay; flavonoids; free radical scavengers; free radicals; fruits; leaf extracts; leaves; methanol; methylene chloride; neuroprotective effect; oxidative stress; pathogenesis; phenol
Abstract:
... Dichloromethane, ethyl acetate, acetone, methanol, and water extracts prepared from the fruits and leaves of Laurocerasus officinalis Roem. (LO) (Rosaceae) were screened for their cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), the key enzymes in pathogenesis of Alzheimer's disease (AD), using ELISA microplate reader at 50, 100, and 200μgmL ...
DOI:
10.1016/j.foodres.2011.01.037

36. Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain

Author:
Vandita Kakkar; Indu Pal Kaur
Source:
Food and chemical toxicology 2011 v.49 no.11 pp. 2906-2913
ISSN:
0278-6915
Subject:
Alzheimer disease; acetylcholinesterase; adverse effects; aluminum; bioavailability; brain; curcumin; etiology; histopathology; lipids; mice; nanoparticles; neurotoxicity; neurotoxins; oral administration; toxicology
Abstract:
... Aluminium, a well established neurotoxicant, is reported to be involved in the aetiology of Alzheimer’s disease (AD) due to its easy admittance and accumulation in central nervous system (CNS). Simultaneous curcumin treatment during the induction of neurotoxicity by AlCl₃ is reported to provide protection. However, the therapeutic potential of curcumin in terms of reversing the neuronal damage onc ...
DOI:
10.1016/j.fct.2011.08.006

37. Evaluation of fruit extracts of six Turkish Juniperus species for their antioxidant, anticholinesterase and antimicrobial activities

Author:
Öztürk, Mehmet; Tümen, İbrahim; Uǧur, Aysel; Aydoǧmuş-Öztürk, Fatma; Topçu, Gülaçtı
Source:
Journal of the science of food and agriculture 2011 v.91 no.5 pp. 867-876
ISSN:
0022-5142
Subject:
Alzheimer disease; Juniperus; acetone; acetylcholinesterase; antimicrobial properties; antioxidant activity; antioxidants; food preservatives; fruit extracts; fruits; hexane; linoleic acid; medicine; methanol; oxidation; oxidative stress; pathogenesis; raw foods; shelf life
Abstract:
... BACKGROUND: Juniperus L. (Cupressaceae) species are mostly spread out in the Northern Hemisphere of the world, and some of them are used as folkloric medicines. The fruits of some species are eaten. Since oxidative stress is one of the reasons for neurodegeneration and is associated with the Alzheimer's disease (AD), the extracts prepared from the fruits of six Juniperus species were screened for ...
DOI:
10.1002/jsfa.4258
PubMed:
21384354

38. In vitro neuroprotective effects of the leaf and fruit extracts of Juglans regia L. (walnut) through enzymes linked to Alzheimer's disease and antioxidant activity

Author:
Ilkay Erdogan Orhan; Ipek Pesin Suntar; Esra Kupeli Akkol
Source:
International journal of food sciences and nutrition 2011 v.62 no.8 pp. 781-786
ISSN:
1465-3478
Subject:
2,2-diphenyl-1-picrylhydrazyl; Alzheimer disease; Juglans regia; acetylcholinesterase; antioxidant activity; cholinesterase; cholinesterase inhibitors; flavonoids; fruits; hydrogen peroxide; leaves; methylene chloride; nitric oxide; nutrition; walnuts
Abstract:
... Several extracts of the leaves and fruits of Juglans regia L. were assessed for their neuroprotective effects through antioxidant and anti-cholinesterase methods. Anticholinesterase activity was determined against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), the enzymes vital for Alzheimer's disease, at 50, 100 and 200 μg ml⁻ ¹. Antioxidant activity was tested using radical scaven ...
DOI:
10.3109/09637486.2011.585964

39. Inhibition of acetylcholinesterase by gallic acid-grafted-chitosans

Author:
Young-Sook Cho; Se-Kwon Kim; Chang-Bum Ahn; Jae-Young Je
Source:
Carbohydrate polymers 2011 v.84 no.1 pp. 690-693
ISSN:
0144-8617
Subject:
Alzheimer disease; acetylcholinesterase; chitosan; cytotoxicity; enzyme inhibition; inhibitory concentration 50
Abstract:
... This paper discusses acetylcholinesterase inhibitory properties of gallic acid-grafted-chitosans (GA-g-chitosans) with different grafting ratios. The GA-g-chitosans exhibited potent acetylcholinesterase inhibitory effects in a dose-dependent manner, and their IC₅₀ values ranged from 138.5±0.25 to 397.6±5.2μg/mL. The acetylcholinesterase inhibition kinetics of the GA-g-chitosan (I) by Lineweaver–Bu ...
DOI:
10.1016/j.carbpol.2010.12.040

40. Isolation of narciprimine from Cyrtanthus contractus (Amaryllidaceae) and evaluation of its acetylcholinesterase inhibitory activity

Author:
Jerald J. Nair; Adeyemi O. Aremu; Johannes van Staden
Source:
Journal of ethnopharmacology 2011 v.137 no.3 pp. 1102-1106
ISSN:
0378-8741
Subject:
Alzheimer disease; Cyrtanthus; Lycoris; Narcissus; Zephyranthes; acetylcholinesterase; bulbs; chromatography; enzyme inhibition; enzyme inhibitors; lycorine; medicinal plants; nuclear magnetic resonance spectroscopy; traditional medicine; South Africa
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: Plants of the family Amaryllidaceae are used widely in traditional medicine in South Africa. Several of these, including representatives of the genus Cyrtanthus find use in the treatment of mental illness and age-related dementia. AIM OF THE STUDY: Based on the distribution of central nervous system-activating alkaloidal constituents within the genus Cyrtanthus, Cyr ...
DOI:
10.1016/j.jep.2011.07.028
PubMed:
21787856

41. Neuroprotective effect of Alpinia galanga (L.) fractions on Aβ₍₂₅–₃₅₎ induced amnesia in mice

Author:
J.C. Hanish Singh; V. Alagarsamy; Prakash V. Diwan; S. Sathesh Kumar; J.C. Nisha; Y. Narsimha Reddy
Source:
Journal of ethnopharmacology 2011 v.138 no.1 pp. 85-91
ISSN:
0378-8741
Subject:
Alpinia galanga; Alzheimer disease; acetates; acetylcholinesterase; antioxidant activity; ascorbic acid; brain; catalase; chloroform; chromatography; cognition; drug therapy; flavor; free radical scavengers; ginger; lead; memory; mice; models; neuroprotective effect; neurotoxicity; oxidative stress; rhizomes; screening; superoxide dismutase; traditional foods
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: The rhizomes of Alpinia galanga (L.) Willd (Zingiberaceae), a ginger substitute for flavouring food was traditionally used as nervine tonic and stimulant. AIM OF THE STUDY: This investigation is designed to screen cognitive improvement of Alpinia galanga (AG) fractions in Alzheimer's type of amnesia in mice induced by Aβ₍₂₅–₃₅₎. MATERIALS AND METHODS: Alzheimer's di ...
DOI:
10.1016/j.jep.2011.08.048
PubMed:
21911048

42. Phylogenetic selection of target species in Amaryllidaceae tribe Haemantheae for acetylcholinesterase inhibition and affinity to the serotonin reuptake transport protein

Author:
M.G.K. Bay-Smidt; A.K. Jäger; K. Krydsfeldt; A.W. Meerow; G.I. Stafford; J. Van Staden; N. Rønsted
Source:
South African journal of botany 2011 v.77 no.1 pp. 175-183
ISSN:
0254-6299
Subject:
Alzheimer disease; Amaryllis belladonna; Haemanthus; Scadoxus; acetylcholinesterase; alkaloids; drugs; flowers; gas chromatography; internal transcribed spacers; mass spectrometry; phylogeny; rain; serotonin; summer; transport proteins
Abstract:
... We present phylogenetic analyses of 37 taxa of Amaryllidaceae, tribe Haemantheae and Amaryllis belladonna L. as an outgroup, in order to provide a phylogenetic framework for the selection of candidate plants for lead discoveries in relation to Alzheimer's disease and depression. DNA sequences from the nuclear ribosomal internal transcribed spacer (ITS) and the plastid trnL-F regions were used. Max ...
DOI:
10.1016/j.sajb.2010.07.016

43. Protective effect of curcumin (Curcuma longa) against d-galactose-induced senescence in mice

Author:
Anil Kumar; Atish Prakash; Samrita Dogra
Source:
Journal of Asian natural products research 2011 v.13 no.1 pp. 42-55
ISSN:
1477-2213
Subject:
Alzheimer disease; locomotion; acetylcholinesterase; glutathione; catalase; galactose; neurodegenerative diseases; lipid peroxidation; brain; Curcuma longa; mice; cholinesterase inhibitors; cognition; curcumin; antioxidant activity; nitrites; enzyme activity; protective effect
Abstract:
... Brain senescence plays an important role in cognitive dysfunction and neurodegenerative disorders. Curcumin was reported to have beneficial effect against several neurodegenerative disorders including Alzheimer's disease. Therefore, the present study was conducted in order to explore the possible role of curcumin against d-galactose-induced cognitive dysfunction, oxidative damage, and mitochondria ...
DOI:
10.1080/10286020.2010.544253

44. Surrogate based accurate quantification of endogenous acetylcholine in murine brain by hydrophilic interaction liquid chromatography–tandem mass spectrometry

Author:
Liang Peng; Tao Jiang; Zhengxing Rong; Ting Liu; Hao Wang; Biyun Shao; Jian Ma; Lan Yang; Lei Kang; Yifeng Shen; Huafang Li; Hong Qi; Hongzhuan Chen
Source:
Journal of chromatography 2011 v.879 no.32 pp. 3927-3931
ISSN:
1570-0232
Subject:
Alzheimer disease; acetonitrile; acetylcholine; acetylcholinesterase; brain; detection limit; equations; formic acid; hydrophilicity; liquid chromatography; mice; monitoring; pH; tandem mass spectrometry
Abstract:
... Cholinergic dysfunction is known as a hallmark feature of Alzheimer's disease (AD). Measurement of endogenous acetylcholine (ACh) in specific brain regions is important in understanding the pathology of AD and in designing and evaluating novel cholinomimetic agents for the treatment of AD. Since ACh is an endogenous neurotransmitter, there is no real blank matrix available to construct standard cu ...
DOI:
10.1016/j.jchromb.2011.09.020

45. Synergistic inhibition of butyrylcholinesterase by galantamine and citalopram

Author:
Ryan Walsh; Kenneth Rockwood; Earl Martin; Sultan Darvesh
Source:
Biochimica et biophysica acta 2011 v.1810 no.12 pp. 1230-1235
ISSN:
0304-4165
Subject:
Alzheimer disease; acetylcholine; acetylcholinesterase; brain; catalytic activity; cognition; combination drug therapy; equations; metabolism
Abstract:
... BACKGROUND: Many persons with Alzheimer's disease (AD) treated with galantamine appear to receive additional cognitive benefit from citalopram. Both drugs inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). These enzymes co-regulate acetylcholine catabolism. In AD brain, AChE is diminished while BuChE is not, suggesting BuChE inhibition may be important in raising acetylcholine ...
DOI:
10.1016/j.bbagen.2011.08.010
PubMed:
21872646
PubMed Central:
PMC3263522

46. Uncaria rhynchophylla Ameliorates Cognitive Deficits Induced by D-galactose in Mice

Author:
Xian, Yan-Fang; Lin, Zhi-Xiu; Zhao, Ming; Mao, Qing-Qiu; Ip, Siu-Po; Che, Chun-Tao
Source:
Planta medica 2011 v.77 no.18 pp. 1977-1983
ISSN:
0032-0943
Subject:
Alzheimer disease; Uncaria rhynchophylla; acetylcholine; acetylcholinesterase; animal models; antioxidants; brain; cognition; ethanol; glutathione; malondialdehyde; memory; mice; neurodegenerative diseases; oral administration; subcutaneous injection
Abstract:
... The stem with hooks of Uncaria rhynchophylla is a component herb of many traditional formulae for the treatment of neurodegenerative diseases. However, scientific evidence of the efficacy of Uncaria rhynchophylla in the treatment of Alzheimer's disease (AD) in animal models is lacking. Thus, in the present study, we investigated whether the 70 % aqueous ethanol extract of Uncaria rhynchophylla (EU ...
DOI:
10.1055/s-0031-1280125
PubMed:
21858756

47. Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria

Author:
Boris Pejin; Giuseppina Tommonaro; Carmine Iodice; Vele Tesevic; Vlatka Vajs
Source:
Natural product research 2012 v.26 no.17 pp. 1634-1637
ISSN:
1478-6427
Subject:
Alzheimer disease; Lobaria; acetylcholinesterase; drugs; lichens; metabolites; thin layer chromatography; Bosnia-Herzegovina
Abstract:
... As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 µg) in the acetylcholinesterase inhibiti ...
DOI:
10.1080/14786419.2011.585989

48. Amperometric choline biosensor based on multiwalled carbon nanotubes/zirconium oxide nanoparticles electrodeposited on glassy carbon electrode

Author:
S. Pundir; N. Chauhan; J. Narang; C.S. Pundir
Source:
Analytical biochemistry 2012 v.427 no.1 pp. 26-32
ISSN:
0003-2697
Subject:
Alzheimer disease; Fourier transform infrared spectroscopy; acetylcholinesterase; biosensors; blood serum; carbon nanotubes; choline; choline oxidase; detection limit; glassy carbon electrode; half life; nanocomposites; nanoparticles; pH; people; scanning electron microscopy; silver chloride; zirconium
Abstract:
... A bienzymatic choline biosensor was constructed by coimmobilizing acetylcholinesterase (AChE) and choline oxidase (ChO) onto nanocomposite of carboxylated multiwalled carbon nanotubes (c-MWCNTs) and zirconium oxide nanoparticles (ZrO₂NPs) electrodeposited on the surface of a glassy carbon electrode (GCE) and using it (AChE–ChO/c-MWCNT/ZrO₂NPs/GCE) as working electrode, Ag/AgCl as reference electro ...
DOI:
10.1016/j.ab.2012.04.027

49. Anticholinesterase and antioxidant activities of Savoury (Satureja thymbra L.) with identified major terpenes of the essential oil

Author:
Mehmet Öztürk
Source:
Food chemistry 2012 v.134 no.1 pp. 48-54
ISSN:
0308-8146
Subject:
Alzheimer disease; Satureja; Thymbra; acetylcholinesterase; acids; antioxidant activity; carvacrol; cholinesterase; essential oils; lipid peroxidation; methanol; oils; p-cymene; spices; terpenoids; thymol; Greece
Abstract:
... Satureja thymbra was used as a spice in Anatolia and Greece. The essential oil and the methanol extract of Satureja thymbra were evaluated for cholinesterase inhibitory effects against acetylcholinesterase and butyrylcholinesterase which are the chief enzymes of Alzheimer’s disease. The antioxidative effects of the essential oil and the extract were also determined by using β-carotene-linoleic aci ...
DOI:
10.1016/j.foodchem.2012.02.054

50. Anticholinesterase potential of flavonols from paper mulberry (Broussonetia papyrifera) and their kinetic studies

Author:
Hyung Won Ryu; Marcus J. Curtis-Long; Sunin Jung; Il Yun Jeong; Dong Sub Kim; Kyu Young Kang; Ki Hun Park
Source:
Food chemistry 2012 v.132 no.3 pp. 1244-1250
ISSN:
0308-8146
Subject:
Alzheimer disease; Broussonetia papyrifera; acetylcholinesterase; ethanol; fluorescence; food additives; humans; medicinal plants; proteins; quercetin
Abstract:
... It is necessary to develop food additives to help treat chronic disorders like neurodegenerative diseases from medicinal plants. Ethanol extracts of paper mulberry were found to display significant inhibition against cholinesterases, enzymes that are strongly linked with Alzheimer’s disease (AD). The active components were identified as prenylated flavonols (2–4) that inhibited two related hum ...
DOI:
10.1016/j.foodchem.2011.11.093

51. Antioxidant and Cholinesterase Inhibition Activities of Three Tricholoma Species with Total Phenolic and Flavonoid Contents: The Edible Mushrooms from Anatolia

Author:
Gülsen Tel; Müjde Apaydın; Mehmet E. Duru; Mehmet Öztürk
Source:
Food analytical methods 2012 v.5 no.3 pp. 495-504
ISSN:
1936-9751
Subject:
Alzheimer disease; Tricholoma; acetates; acetylcholinesterase; acids; antioxidant activity; antioxidants; chelates; cholinesterase; food additives; hexane; ions; lipid peroxidation; mushrooms; pathogenesis; pyrocatechol; quercetin
Abstract:
... Tricholoma species, known as odorous mushrooms, are consumed in Anatolia as well as in the world. The antioxidant activity of extracts of Tricholoma fracticum, Tricholoma imbricatum and Tricholoma terreum was determined using five complementary tests: β-carotene/linoleic acid, DPPH[Symbol: see text] scavenging, ABTS[Symbol: see text]+ scavenging, ferrous ion chelating assay and cupric-reducing an ...
DOI:
10.1007/s12161-011-9275-4

52. Attenuation of scopolamine-induced cognitive dysfunction by obovatol

Author:
Dong-Young Choi; Young-Jung Lee; Sun Young Lee; Yoot Mo Lee; Hyun Hee Lee; Im Seop Choi; Ki-Wan Oh; Sang Bae Han; Sang-Yoon Nam; Jin Tae Hong
Source:
Archives of pharmacal research 2012 v.35 no.7 pp. 1279-1286
ISSN:
0253-6269
Subject:
Alzheimer disease; acetylcholinesterase; amyloid; cholinergic receptors; cognition; cortex; dose response; elderly; enzyme activity; hippocampus; memory; people; scopolamine; synaptic transmission
Abstract:
... Alzheimer’s disease (AD) is the most prevalent cause of dementia in the elderly people. The disease is pathologically characterized by extracellular deposition of beta-amyloid peptide (Aβ), cholinergic neurodegeneration and elevation of acetylcholine esterase (AChE) activity in the affected regions. In this study, we investigated the effects of obovatol on memory dysfunction, which was caused by s ...
DOI:
10.1007/s12272-012-0719-1

53. Catechol alkenyls from Semecarpus anacardium: Acetylcholinesterase inhibition and binding mode predictions

Author:
H.R. Adhami; T. Linder; H. Kaehlig; D. Schuster; M. Zehl; L. Krenn
Source:
Journal of ethnopharmacology 2012 v.139 no.1 pp. 142-148
ISSN:
0378-8741
Subject:
Alzheimer disease; Ayurvedic medicine; Semecarpus anacardium; Torpedo californica; acetylcholinesterase; active sites; catechol; cholinesterase; computer software; databases; fractionation; fruits; high performance liquid chromatography; inhibitory concentration 50; mass spectrometry; methylene chloride; nuclear magnetic resonance spectroscopy; screening
Abstract:
... ETHNOPHARMACOLOGICAL RELEVANCE: The fruits of Semecarpus anacardium L. f. (Anacardiaceae) are used in Ayurvedic medicine and also in Iranian Traditional Medicine for various indications, among those for retarding and treatment of dementia. AIM OF THE STUDY: The severity of Alzheimer's disease obviously correlates with a cholinergic deficit. In a screening for acetylcholinesterase (AChE) inhibitory ...
DOI:
10.1016/j.jep.2011.10.032
PubMed:
22075454

54. Chiral separation of Huperzine A using CE – Method validation and application in pharmaceutical formulations

Author:
Despina A. Tsioupi; Irene N. Nicolaou; Leonard Moore; Constantina P. Kapnissi‐Christodoulou
Source:
Electrophoresis 2012 v.33 no.3 pp. 516-522
ISSN:
0173-0835
Subject:
Alzheimer disease; acetates; acetylcholinesterase; bioactive properties; drug formulations; electrophoresis; micellar electrokinetic capillary chromatography; pH; temperature
Abstract:
... The aim of this work is the development, validation and application of an MEKC method for the chiral separation of Huperzine A. Huperzine A is an important compound that is used to treat Alzheimer's disease. However, only the (−)‐form of this compound is biologically active and behaves as a potential acetylcholinesterase inhibitor. Therefore, the separation of the (−)‐form from the (+)‐f ...
DOI:
10.1002/elps.201100372

55. Effect of quercetin on learning and memory performance in ICR mice under neurotoxic trimethyltin exposure

Author:
Gwi Nam Choi; Ji Hye Kim; Ji Hyun Kwak; Chang-Ho Jeong; Hee Rok Jeong; Uk Lee; Ho Jin Heo
Source:
Food chemistry 2012 v.132 no.2 pp. 1019-1024
ISSN:
0308-8146
Subject:
Alzheimer disease; acetylcholinesterase; antioxidant activity; brain; malondialdehyde; memory; mice; neurotoxicity; peroxidation; plasma membrane; polyunsaturated fatty acids; quercetin
Abstract:
... To investigate the anti-amnesic effect of quercetin by using in vivo Y-maze and passive avoidance tests, the learning and memory impairment in ICR mice was induced by neurotoxic trimethyltin. Quercetin pre-administration attenuated TMT-induced memory injury in both in vivo tests. Acetylcholinesterase (AChE), prepared from mice brain tissues, was inhibited by quercetin in a dose-dependent manner. M ...
DOI:
10.1016/j.foodchem.2011.11.089

56. Ergothioneine protects against neuronal injury induced by β-amyloid in mice

Author:
Nae-Cherng Yang; Hung-Chi Lin; Jhoa-Huei Wu; Hsiu-Chung Ou; Yu-Chin Chai; Chin-Yin Tseng; Jiunn-Wang Liao; Tuzz-Ying Song
Source:
Food and chemical toxicology 2012 v.50 no.11 pp. 3902-3911
ISSN:
0278-6915
Subject:
Alzheimer disease; acetylcholinesterase; body weight; glutathione; hippocampus; lipid peroxidation; memory; mice; neurotoxicity; protective effect; superoxide dismutase; tissues; toxicology
Abstract:
... β-Amyloid peptides (Aβ) are neurotoxic and contribute to the development of Alzheimer’s disease (AD). Ergothioneine (EGT) has been shown to protect against loss of memory and learning abilities in mice. In this study, mice were orally fed EGT (0.5 or 2mg/kg body weight) for 16days before treatment (i.c.v) with a single dose of Aβ1–40 in the hippocampus. After resting for 12days to restore the body ...
DOI:
10.1016/j.fct.2012.08.021

57. Evaluation of Citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti‐cholinesterase activities

Author:
Monica Rosa Loizzo; Rosa Tundis; Marco Bonesi; Federica Menichini; Damiano De Luca; Carmela Colica; Francesco Menichini
Source:
Journal of the science of food and agriculture 2012 v.92 no.15 pp. 2960-2967
ISSN:
0022-5142
Subject:
Alzheimer disease; acetylcholinesterase; acids; antioxidant activity; apigenin; biphenyl; bleaching; chemical composition; citrus peels; foods; free radical scavengers; gas chromatography; human health; kaempferol; leaf extracts; leaves; liquid chromatography; mass spectrometry; methanol; monoterpenoids; phenol; quercetin; rutin; screening; sesquiterpenoids; vegetables
Abstract:
... BACKGROUND: The replacement of synthetic antioxidants by safe natural antioxidants fosters research on the screening of vegetables and food as sources of new antioxidants. Moreover, oxidative degeneration of cells is associated with neurodegenerative diseases such as Alzheimer's disease. On the basis of these considerations this work aimed to investigate the antioxidant properties [by using the di ...
DOI:
10.1002/jsfa.5708
PubMed:
22589172

58. Facile synthesis of oxo-/thioxopyrimidines and tetrazoles C–C linked to sugars as novel non-toxic antioxidant acetylcholinesterase inhibitors

Author:
J.A. Figueiredo; M.I. Ismael; J.M. Pinheiro; A.M.S. Silva; J. Justino; F.V.M. Silva; M. Goulart; D. Mira; M.E.M. Araújo; R. Campoy; A.P. Rauter
Source:
Carbohydrate research 2012 v.347 no.1 pp. 47-54
ISSN:
0008-6215
Subject:
Alzheimer disease; acetylcholinesterase; antioxidant activity; antioxidants; chromosome aberrations; copper sulfate; cytotoxicity; gallic acid; genotoxicity; heat; humans; hydroxylamine; inhibitory concentration 50; lymphocytes; microwave radiation; microwave treatment; sodium azide; sugars; thiourea; triethylamine; urea
Abstract:
... Microwave-assisted synthesis of oxo-/thioxopyrimidines and tetrazoles linked to furanoses with d-xylo and d-ribo configuration, and to a d-galacto pyranose is reported and compared to conventional methods. Reaction of dialdofuranoses and dialdopyranoses with a β-keto ester and urea or thiourea under microwave irradiation at 300W gave in 10min the target molecules containing the 2-oxo- or 2-thioxo- ...
DOI:
10.1016/j.carres.2011.11.006

59. Huperzia quadrifariata and Huperzia reflexa alkaloids inhibit acetylcholinesterase activity in vivo in mice brain

Author:
E.L. Konrath; B.M. Neves; C.dos S. Passos; P.S. Lunardi; M.G. Ortega; J.L. Cabrera; C.A. Gonçalves; A.T. Henriques
Source:
Phytomedicine 2012 v.19 no.14 pp. 1321-1324
ISSN:
0944-7113
Subject:
Alzheimer disease; Huperzia serrata; Lycopodium; acetylcholinesterase; alkaloids; colorimetry; cortex; drugs; enzyme inhibition; hippocampus; memory; mice; patients
Abstract:
... Huperzine A, a Lycopodium alkaloid produced by Chinese folk herb Huperzia serrata (Lycopodiaceae), has been shown to be a promising agent for the treatment of Alzheimer's disease due to its potent acetylcholinesterase (AChE) activity, as well its efficacy in the treatment of memory of aged patients. Thus, the effects of two Huperzia species of habitats in Brazil (H. quadrifariata and H. reflexa) w ...
DOI:
10.1016/j.phymed.2012.08.009

60. Inhibition of acetylcholinesterase activities and some pro-oxidant induced lipid peroxidation in rat brain by two varieties of ginger (Zingiber officinale)

Author:
Ganiyu Oboh; Adedayo O. Ademiluyi; Ayodele J. Akinyemi
Source:
Experimental and toxicologic pathology 2012 v.64 no.4 pp. 315-319
ISSN:
0940-2993
Subject:
Alzheimer disease; Zingiber officinale; acetylcholinesterase; alkaloids; brain; dose response; flavonoids; ginger; lipid peroxidation; malondialdehyde; medicine; nitroprusside; phytopharmaceuticals; rats; single nucleotide polymorphism; tannins; terpenoids
Abstract:
... Ginger has been reportedly used for the management or treatment of Alzheimer's disease in folklore medicine. Therefore, this study sought to investigate the inhibitory effects of water extractable phytochemicals of red and white ginger on acetylcholinesterase activities, and sodium nitroprusside (SNP) and quinolinic acid (QA)-induced lipid peroxidation in rat brain –in vitro. Both extracts inhibit ...
DOI:
10.1016/j.etp.2010.09.004

61. Inhibition of acetylcholinesterase by green and white tea and their simulated intestinal metabolites

Author:
Edward J. Okello; Ramin Leylabi; Gordon J. McDougall
Source:
Food & function 2012 v.3 no.6 pp. 651-661
ISSN:
2042-650X
Subject:
Alzheimer disease; Camellia sinensis; acetylcholinesterase; bioavailability; caffeine; cardiovascular diseases; enzyme inhibition; epigallocatechin gallate; flavanols; gallic acid; green tea; health promotion; in vitro digestion; inhibitory concentration 50; intestines; lactones; metabolites; neoplasms; polyphenols; pyrogallol; tea (beverage); white tea
Abstract:
... By 2034 it is forecast that 5% of the global population will be aged 85 years or over—approximately two and half fold increase on present day figures—which will inevitably lead to an increase in age-associated disorders such as Alzheimer's disease. There is mounting evidence that green tea (Camellia sinensis) possesses numerous health-promoting properties, and may potentially be beneficial to thos ...
DOI:
10.1039/c2fo10174b

62. Inhibition of cholinesterase by essential oil from food plant

Author:
Wantida Chaiyana; Siriporn Okonogi
Source:
Phytomedicine 2012 v.19 no.8-9 pp. 836-839
ISSN:
0944-7113
Subject:
Alzheimer disease; Citrus aurantiifolia; Melissa officinalis; acetylcholinesterase; cholinesterase; cineole; citronellol; colorimetry; essential oils; food plants; gas chromatography-mass spectrometry; inhibitory concentration 50; leaves; limonene; plant fats and oils
Abstract:
... Inhibition of cholinesterase has attracted much attention recently because of its potential for the treatment of Alzheimer's disease. In this work, the anticholinesterase activities of plant oils were investigated using Ellman's colorimetric method. The results indicate that essential oils obtained from Melissa officinalis leaf and Citrus aurantifolia leaf showed high acetylcholinesterase and buty ...
DOI:
10.1016/j.phymed.2012.03.010

63. In vitro toxicity, antiplatelet and acetylcholinesterase inhibition of Buddleja thyrsoides Lam. leaves

Author:
Janaína Dorneles Mahlke; Aline Augusti Boligon; Michel Mansur Machado; Margareth Linde Athayde
Source:
Natural product research 2012 v.26 no.23 pp. 2223-2226
ISSN:
1478-6427
Subject:
Alzheimer disease; Artemia; Buddleja; acetylcholinesterase; bronchitis; cough; ethyl acetate; flowers; inhibitory concentration 50; leaves; lethal concentration 50; memory; methylene chloride; neurodegenerative diseases; socioeconomics; toxicity; traditional medicine; South America
Abstract:
... Alzheimer's disease (AD) is a neurodegenerative disorder resulting in impaired memory and behaviour of remarkable socio-economic impact. A decrease in cholinergic activity is a key event in the biochemical of AD. Buddleja thyrsoides is a plant widely distributed in Southern parts of South America. In Brazilian traditional medicine, the infusion of its leaves and flowers is used for the treatment o ...
DOI:
10.1080/14786419.2011.643884

64. Modulatory effects of vitamin E, acetyl-l-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model

Author:
Hanaa H. Ahmed
Source:
Experimental and toxicologic pathology 2012 v.64 no.6 pp. 549-556
ISSN:
0940-2993
Subject:
Alzheimer disease; acetylcholinesterase; adenosinetriphosphatase; animal models; biomarkers; brain; dietary supplements; folic acid; functional foods; homocysteine; inflammation; insulin; insulin-like growth factor I; interleukin-1beta; lipoic acid; necrosis; neurodegenerative diseases; rats; sodium-potassium-exchanging ATPase; tumor necrosis factor-alpha; vitamin B12; vitamin E
Abstract:
... Alzheimer's disease (AD) is the most common chronic neurodegenerative disorder associated with aging. This study aimed to explore new markers for AD as total homocysteine (tHcy), insulin, insulin like growth factor-1 (IGF-1), interlukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α); to determine the modulatory effects of vitamin E (VE), acetyl-l-carnitine (ALC) and α-lipoic acid (LA) on the inves ...
DOI:
10.1016/j.etp.2010.11.012

65. Phytochemical profile of a blend of black chokeberry and lemon juice with cholinesterase inhibitory effect and antioxidant potential

Author:
Amadeo Gironés-Vilaplana; Patrícia Valentão; Paula B. Andrade; Federico Ferreres; Diego A. Moreno; Cristina García-Viguera
Source:
Food chemistry 2012 v.134 no.4 pp. 2090-2096
ISSN:
0308-8146
Subject:
Alzheimer disease; Aronia melanocarpa; Parkinson disease; acetylcholinesterase; antioxidant activity; beverages; cholinesterase; citric acid; coumaric acids; flavanones; hydroxyl radicals; lemon juice; lemons; quercetin
Abstract:
... In this study, black chokeberry concentrate was added (5% w/v) to lemon juice, since previous reports suggested potential health benefits of this blend. The phytochemical composition, antioxidant capacity (scavenging of DPPH, superoxide and hydroxyl radicals, and hypochlorous acid), and inhibitory activity against cholinesterase of the new blend were determined and compared with those of lemon jui ...
DOI:
10.1016/j.foodchem.2012.04.010
PubMed:
23442660

66. Smaller quantal size and faster kinetics of single exocytotic events in chromaffin cells from the APP/PS1 mouse model of Alzheimer’s disease

Author:
Antonio M.G. de Diego; Silvia Lorrio; Enrique Calvo-Gallardo; Antonio G. García
Source:
Biochemical and biophysical research communications 2012 v.428 no.4 pp. 482-486
ISSN:
0006-291X
Subject:
Alzheimer disease; acetylcholinesterase; adrenal medulla; amyloid; animal models; chromaffin cells; cortex; exocytosis; feet; fluorescent antibody technique; hippocampus; innervation; mice; nerve tissue; potassium
Abstract:
... The kinetics of single-amperometric exocytotic events has been measured in chromaffin cells of C57 mice and in an APP/PS1 mouse model of Alzheimer’s disease (AD). K⁺ depolarisation causes a burst of spikes that indicate the quantal release of the single-vesicle content of catecholamine. The kinetic analysis of 278 spikes from 10 control cells and 520 spikes from 18 APP/PS1 cells shows the followin ...
DOI:
10.1016/j.bbrc.2012.10.082

67. Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure–activity relationships

Author:
Zhong-Duo Yang; Dong-Zhu Duan; Wei-Wei Xue; Xiao-Jun Yao; Shuo Li
Source:
Life sciences 2012 v.90 no.23-24 pp. 929-933
ISSN:
0024-3205
Subject:
Alzheimer disease; Holarrhena pubescens; acetylcholinesterase; active sites; alkaloids; chromatography; fractionation; herbal medicines; inhibitory concentration 50; models; new drugs; seeds; structure-activity relationships
Abstract:
... AIMS: Inhibition of acetylcholinesterase (AChE) is still considered as a strategy for the treatment of neurological disorders such as Alzheimer's disease (AD). Many plant derived alkaloids (such as huperzine A, galanthamine and rivastigmine) are known for their AChE inhibitory activity. The aim of the present work was to isolate and identify new AChE inhibitors from Holarrhen antidysenterica. MAIN ...
DOI:
10.1016/j.lfs.2012.04.017

68. Tacrine-induced tachyphylaxis in gastric smooth muscles

Author:
Natalia Prissadova; Athanas Kristev; Daminka Getova; Mariana Argirova; Valentin Turiiski; Raina Ardasheva
Source:
Open life sciences 2012 v.7 no.6 pp. 1013-1020
ISSN:
2391-5412
Subject:
Alzheimer disease; Ca2-transporting ATPase; acetylcholine; acetylcholinesterase; adenylate cyclase; atropine; cGMP-dependent protein kinase; cyclopiazonic acid; drug therapy; endoplasmic reticulum; muscle contraction; muscle strength; muscles; nitric oxide; nitric oxide synthase; rats; receptors; smooth muscle; stomach
Abstract:
... Tacrine is a medication applied in cases of mild to moderate dementia in Alzheimer’s disease. By blocking acetylcholinesterase activity the drug increases the concentration of acetylcholine, whose effects influence the functions of different organs and systems of the body. The effect of tacrine on smooth muscle preparations isolated from rat stomach was studied by isometric registration of muscle ...
DOI:
10.2478/s11535-012-0103-7

69. A novel 7-O-modified genistein derivative with acetylcholinesterase inhibitory effect, estrogenic activity and neuroprotective effect

Author:
Da-Hua Shi; Zhi-Qiang Yan; Li-Na Zhang; Yu-Rong Wang; Chun-Ping Jiang; Jun-Hua Wu
Source:
Archives of pharmacal research 2012 v.35 no.9 pp. 1645-1654
ISSN:
0253-6269
Subject:
Alzheimer disease; acetylcholinesterase; dissociation; estrogen receptors; estrogenic properties; genistein; inhibitory concentration 50; molecular models; neuroprotective effect
Abstract:
... To find the multi-target-directed compounds for the treatment of Alzheimer’s disease (AD), we synthesized 7-(4-(diethylamino)butoxy)-5-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one, a novel 7-O-modified genistein derivative (GS-14), and investigated its acetylcholinesterase (AChE) inhibitory effect, estrogenic activity and neuroprotective effect. GS-14 acted as a selective AChE inhibitor in vitro, ...
DOI:
10.1007/s12272-012-0916-y

70. Acetylcholinesterase immobilized capillary reactors coupled to protein coated magnetic beads: A new tool for plant extract ligand screening

Author:
Kenia Lourenço Vanzolini; Zhengjin Jiang; Xiaoqi Zhang; Lucas Campos Curcino Vieira; Arlene Gonçalvez Corrêa; Carmen Lucia Cardoso; Quezia Bezerra Cass; Ruin Moaddel
Source:
Talanta 2013 v.116 no. pp. 647-652
ISSN:
0039-9140
Subject:
Alzheimer disease; acetylcholinesterase; bioreactors; central nervous system; chromatography; insecticides; ligands; plant extracts; screening
Abstract:
... The use of immobilized capillary enzyme reactors (ICERs) and enzymes coated to magnetic beads ((NT or CT)-MB) for ligand screening has been adopted as a new technique of high throughput screening (HTS). In this work the selected target was the enzyme acetylcholinesterase (AChE), which acts on the central nervous system and is a validated target for the treatment of Alzheimer’s disease, as well as ...
DOI:
10.1016/j.talanta.2013.07.046
PubMed:
24148457
PubMed Central:
PMC3826612

71. Acetylcholinesterase inhibitory effects of the bulb of Ammocharis coranica (Amaryllidaceae) and its active constituent lycorine

Author:
I.L. Elisha; E.E. Elgorashi; A.A. Hussein; G. Duncan; J.N. Eloff
Source:
South African journal of botany 2013 v.85 pp. 44-47
ISSN:
0254-6299
Subject:
Alzheimer disease; Amaryllidaceae; acetylcholinesterase; bulbs; butanol; ethanol; ethyl acetate; fractionation; inhibitory concentration 50; lycorine; pathophysiology
Abstract:
... Ammocharis coranica (Ker-Gawl.) Herb. (Amaryllidaceae) is used in southern Africa for the treatment of mental illnesses. The ethanol extracts of the bulb of A. coranica and its total alkaloids rich fractions were screened for inhibition of acetylcholinesterase enzyme (AChE), which is implicated in the pathophysiology of Alzheimer's disease. The ethanolic extracts significantly inhibited AChE with ...
DOI:
10.1016/j.sajb.2012.11.008

72. Assessment of cholinesterase and tyrosinase inhibitory and antioxidant effects of Hypericum perforatum L. (St. John's wort)

Author:
M. Levent Altun; Betül Sever Yılmaz; Ilkay Erdogan Orhan; Gülcin Saltan Citoglu
Source:
Industrial crops and products 2013 v.43 pp. 87-92
ISSN:
0926-6690
Subject:
Alzheimer disease; Hypericum perforatum; Parkinson disease; acetates; acetylcholinesterase; antioxidant activity; cholinesterase; flavonoids; free radicals; methanol; neuroprotective effect; nitric oxide; phenol
Abstract:
... In the current study, in vitro neuroprotective effect of the ethyl acetate, methanol, and water extracts of Hypericum perforatum L. growing in Turkey was investigated through testing against acetylcholinesterase and butyrylcholinesterase at 50, 100, and 200μgmL−1, linked to Alzheimer's disease, and tyrosinase at 250μgmL−1, related to Parkinson's disease. As neurodegeneration is strongly correlated ...
DOI:
10.1016/j.indcrop.2012.07.017

73. Catalpol improves cholinergic function and reduces inflammatory cytokines in the senescent mice induced by d-galactose

Author:
Xiuli Zhang; Changzhu Jin; Yachen Li; Shui Guan; Fang Han; Shuping Zhang
Source:
Food and chemical toxicology 2013 v.58 pp. 50-55
ISSN:
0278-6915
Subject:
neuroprotective effect; Alzheimer disease; acetylcholinesterase; neurons; interleukin-1beta; immunohistochemistry; biomarkers; galactose; brain; Western blotting; choline acetyltransferase; cholinergic receptors; enzyme-linked immunosorbent assay; mice; toxicology; tumor necrosis factor-alpha; neurodegenerative diseases; catalpol; advanced glycation end products; roots
Abstract:
... The neuroprotective effects of catalpol, an iridoid glycoside isolated from the fresh rehmannia roots, on the cholinergic system and inflammatory cytokines in the senescent mice brain induced by d-galactose were assessed. The results showed that acetylcholinesterase (AChE) activity increased in senescent mice brain and choline acetyltransferase (ChAT) positive neurons, detected by immunohistochemi ...
DOI:
10.1016/j.fct.2013.04.006

74. Chemistry and functional properties in prevention of neurodegenerative disorders of five Cistus species essential oils

Author:
Monica Rosa Loizzo; Mariem Ben Jemia; Felice Senatore; Maurizio Bruno; Francesco Menichini; Rosa Tundis
Source:
Food and chemical toxicology 2013 v.59 pp. 586-594
ISSN:
0278-6915
Subject:
Alzheimer disease; Cistus creticus; acetylcholinesterase; antioxidant activity; beta-carotene; bleaching; chemical composition; essential oils; food additives; functional foods; functional properties; gas chromatography; inhibitory concentration 50; iron; mass spectrometry; neurodegenerative diseases; oils
Abstract:
... The chemical composition of Cistus creticus, Cistus salvifolius, Cistus libanotis, Cistus monspeliensis and Cistus villosus essential oils has been examined by GC and GC–MS analysis. Height-nine constituents were identified in C. salvifolius oil, sixty in C. creticus, fifty-six in C. libanotis, fifty-four in C. villosus, forty-five in C. monspeliensis. Although the five species belong to the same ...
DOI:
10.1016/j.fct.2013.06.040

75. Daffodils as potential crops of galanthamine. Assessment of more than 100 ornamental varieties for their alkaloid content and acetylcholinesterase inhibitory activity

Author:
Laura Torras-Claveria; Strahil Berkov; Carles Codina; Francesc Viladomat; Jaume Bastida
Source:
Industrial crops and products 2013 v.43 pp. 237-244
ISSN:
0926-6690
Subject:
Alzheimer disease; Narcissus; acetylcholinesterase; bioactive properties; bulbs; crops; leaves; quantitative analysis
Abstract:
... Many plant varieties of Narcissus (Amaryllidaceae) are cultivated on a large scale for ornamental purposes but they are also known to contain galanthamine, a bioactive alkaloid used in antiacetylcholinesterasic therapy in Alzheimer's disease.More than 100 ornamental varieties of Narcissus, using leaves and bulbs separately, were screened for their galanthamine content as well as their acetylcholin ...
DOI:
10.1016/j.indcrop.2012.07.034

76. Draft Genome Sequence of Cladonia macilenta KoLRI003786, a Lichen-Forming Fungus Producing Biruloquinone

Author:
Sook-Young Park; Jaeyoung Choi; Jung A Kim; Min-Hye Jeong; Soonok Kim; Yong-Hwan Lee; Jae-Seoun Hur
Source:
Genome announcements 2013 v.1 no.5 pp. e00695-13
ISSN:
2169-8287
Subject:
Alzheimer disease; Cladonia; acetylcholinesterase; biochemical pathways; fungi; genome; neurodegenerative diseases; nucleotide sequences
Abstract:
... The lichen-forming fungus Cladonia macilenta strain KoLRI003786 is capable of producing an acetylcholinesterase inhibitor, biruloquinone, which effectively prevents neurodegeneration in Alzheimer’s disease. Laying the foundation to unravel the biruloquinone biosynthetic pathway, we present the 37.11-Mb draft genome sequence of strain KoLRI003786. ...
DOI:
10.1128/genomeA.00695-13
PubMed:
24009123
PubMed Central:
PMC3764418

77. Droplet-based microfluidics for dose–response assay of enzyme inhibitors by electrochemical method

Author:
Shuqing Gu; Youlan Lu; Yaping Ding; Li Li; Fenfen Zhang; Qingsheng Wu
Source:
Analytica chimica acta 2013 v.796 pp. 68-74
ISSN:
0003-2670
Subject:
Alzheimer disease; acetylcholinesterase; carbaryl; chemical reactions; chlorpyrifos; dose response; drugs; electrochemistry; enzyme inhibition; enzyme inhibitors; inhibitory concentration 50; oils; screening; surfactants
Abstract:
... A simple but robust droplet-based microfluidic system was developed for dose–response enzyme inhibition assay by combining concentration gradient generation method with electrochemical detection method. A slotted-vials array and a tapered tip capillary were used for reagents introduction and concentration gradient generation, and a polydimethylsiloxane (PDMS) microfluidic chip integrated with micr ...
DOI:
10.1016/j.aca.2013.08.016

78. Flavoring Extracts of Hemidesmus indicus Roots and Vanilla planifolia Pods Exhibit In vitro Acetylcholinesterase Inhibitory Activities

Author:
Anish Kundu; Adinpunya Mitra
Source:
Plant foods for human nutrition 2013 v.68 no.3 pp. 247-253
ISSN:
0921-9668
Subject:
Alzheimer disease; Hemidesmus indicus; Vanilla planifolia; acetylcholinesterase; flavorings; inhibitory concentration 50; phenolic compounds; plant extracts; plant-based foods; pods; roots; vanillin
Abstract:
... Acetylcholinesterase inhibitors (AChEIs) are important for treatment of Alzheimer’s disease and other neurological disorders. Search for potent and safe AChEIs from plant sources still continues. In the present work, we explored fragrant plant extracts that are traditionally used in flavoring foods, namely, Hemidesmus indicus and Vanilla planifolia, as possible sources for AChEI. Root and pod extr ...
DOI:
10.1007/s11130-013-0363-z
PubMed:
23715789

79. Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase

Author:
Manuela Bartolini; Marina Naldi; Dan V. Nicolau; Falco C. M. J. M. van Delft; Jeroen van Zijl; Jaap Snijder; Eric F. C. van den Heuvel; Emile P. Naburgh; Natalia Calonghi; Vincenza Andrisano
Source:
Analytical and bioanalytical chemistry 2013 v.405 no.2-3 pp. 795-804
ISSN:
1618-2642
Subject:
Alzheimer disease; acetylcholinesterase; atomic force microscopy; binding sites; confocal laser scanning microscopy; drugs; enzyme activity; fluorescence; humans; propidium; silica; silicon
Abstract:
... Human acetylcholinesterase (AChE) is a widely studied target enzyme in drug discovery for Alzheimer’s disease (AD). In this paper we report evaluation of the optimum structure and chemistry of the supporting material for a new AChE-based fluorescence sensing surface. To achieve this objective, multilayered silicon wafers with spatially controlled geometry and chemical diversity were fabricated. Sp ...
DOI:
10.1007/s00216-012-6237-7

80. Label-free fluorometric assay for acetylcholinesterase and inhibitor screening based on supramolecular assemblies

Author:
Lan Jia; Jun Pan; Jingxin Zhu
Source:
Analytical methods 2013 v.5 no.20 pp. 5431-5436
ISSN:
1759-9679
Subject:
Alzheimer disease; acetylcholinesterase; cationic surfactants; detection limit; drugs; encapsulation; enzymatic hydrolysis; fluorescent dyes; fluorometry; heparin; hydrophobicity; screening
Abstract:
... A new, easily prepared, inexpensive and facile fluorometric assay method for screening of acetylcholinesterase (AChE) and its inhibitor is successfully established with the supramolecular assemblies of myristoylcholine and heparin. Myristoylcholine, an amphiphilic compound, is chosen as the cationic surfactant as well as the substrate for AChE. The environment-dependent dye pyrene, encapsulated in ...
DOI:
10.1039/c3ay41007b

81. Lactoferrin-modified PEG-co-PCL nanoparticles for enhanced brain delivery of NAP peptide following intranasal administration

Author:
Zhongyang Liu; Mengyin Jiang; Ting Kang; Deyu Miao; Guangzhi Gu; Qingxiang Song; Lei Yao; Quanyin Hu; Yifan Tu; Zhiqing Pang; Hongzhuan Chen; Xinguo Jiang; Xiaoling Gao; Jun Chen
Source:
Biomaterials 2013 v.34 no.15 pp. 3870-3881
ISSN:
0142-9612
Subject:
Alzheimer disease; X-ray photoelectron spectroscopy; acetylcholinesterase; binding proteins; cerebellum; cerebrum; choline acetyltransferase; drug delivery systems; drugs; endocytosis; epithelial cells; fluorescence; hippocampus; intranasal administration; lactoferrin; memory; mice; nanoparticles; neurons; neuroprotective effect; olfactory bulb; particle size distribution; peptides; rats; zeta potential
Abstract:
... Development of effective non-invasive drug delivery systems is of great importance to the treatment of Alzheimer's diseases and has made great progress in recent years. In this work, lactoferrin (Lf), a natural iron binding protein, whose receptor is highly expressed in both respiratory epithelial cells and neurons is here utilized to facilitate the nose-to-brain drug delivery of neuroprotection p ...
DOI:
10.1016/j.biomaterials.2013.02.003

82. Linking pesticide exposure and dementia: What is the evidence?

Author:
Ioannis Zaganas; Stefania Kapetanaki; Vassileios Mastorodemos; Konstantinos Kanavouras; Claudio Colosio; Martin F. Wilks; Aristidis M. Tsatsakis
Source:
Toxicology 2013 v.307 pp. 3-11
ISSN:
0300-483X
Subject:
Alzheimer disease; acetylcholinesterase; chronic exposure; cognition; drugs; mechanism of action; organophosphorus compounds; pathogenesis; patients; pesticides; public health; toxicology
Abstract:
... There has been a steep increase in the prevalence of dementia in recent decades, which has roughly followed an increase in pesticide use some decades earlier, a time when it is probable that current dementia patients could have been exposed to pesticides. This raises the question whether pesticides contribute to dementia pathogenesis. Indeed, many studies have found increased prevalence of cogniti ...
DOI:
10.1016/j.tox.2013.02.002

83. Lycopodiaceae from Panama: A new source of acetylcholinesterase inhibitors

Author:
Angela I. Calderón; Johayra Simithy-Williams; Rocío Sanchez; Alex Espinosa; Iván Valdespino; Mahabir P. Gupta
Source:
Natural product research 2013 v.27 no.4-5 pp. 500-505
ISSN:
1478-6427
Subject:
Alzheimer disease; Huperzia; Lycopodium; acetylcholinesterase; alkaloids; antioxidant activity; indigenous species; plant extracts; thin layer chromatography; Panama
Abstract:
... Acetylcholinesterase (AChE) inhibitors have been used for the symptomatic treatment of Alzheimer's disease. Eleven whole plants from Panama belonging to the Lycopodiaceae family have been screened for their anticholinesterase inhibitory and antioxidant activities by a thin-layer chromatography (TLC) bioautography method. Of these, only Lycopodium clavatum subsp. clavatum showed strong AChE inhibit ...
DOI:
10.1080/14786419.2012.701217

84. Miniaturized electrochemical system for cholinesterase inhibitor detection

Author:
Anthony J. Veloso; Paul M. Nagy; Biao Zhang; Devjani Dhar; Anqi Liang; Tarek Ibrahim; Svetlana Mikhaylichenko; Isabelle Aubert; Kagan Kerman
Source:
Analytica chimica acta 2013 v.774 pp. 73-78
ISSN:
0003-2670
Subject:
Alzheimer disease; acetylcholinesterase; ascorbic acid; cholinesterase; colorimetry; cortex; cysteine; electrochemistry; electrodes; glutathione; gold; homocysteine; humans; inhibitory concentration 50; methionine; mice; oxidation; screening
Abstract:
... The utility of a simple, low-cost detection platform for label-free electrochemical characterization of acetylcholinesterase (AChE) inhibition is demonstrated as a potential tool for screening of small-molecule therapeutic agents for Alzheimer's disease (AD). Technique validation was performed against the standard Ellman's colorimetric assay using the clinically established cholinesterase inhibito ...
DOI:
10.1016/j.aca.2013.02.033

85. Neuroprotective Effect of Lutein Against 3-Nitropropionic Acid–Induced Huntington's Disease–Like Symptoms: Possible Behavioral, Biochemical, and Cellular Alterations

Author:
Binawade Yogita; Jagtap Aarti
Source:
Journal of medicinal food 2013 v.16 no.10 pp. 934-943
ISSN:
1557-7600
Subject:
3-nitropropionic acid; Alzheimer disease; acetylcholinesterase; antioxidants; body weight changes; brain; catalase; clinical trials; cognition; energy; histopathology; lipid peroxidation; locomotion; lutein; memory; mitochondria; neuroprotective effect; neurotoxicity; nitrites; oxidative stress; rats; succinate dehydrogenase (quinone)
Abstract:
... 3-Nitropropionic acid (3-NP) induces cellular energy deficit and oxidative stress–related neurotoxicity via an irreversible inhibition of mitochondrial complex II enzyme, succinate dehydrogenase. Huntington's disease (HD) is a neurological disorder characterized by cognitive and motor dysfunctions. Lutein is a well-known antioxidant used in the management of oxidative stress related diseases. Clin ...
DOI:
10.1089/jmf.2012.2698

86. Purification of Acetylcholinesterase by 9-Amino-1,2,3,4-tetrahydroacridine from Human Erythrocytes

Author:
Habibe Budak Kaya; Bilge Özcan; Melda Şişecioğlu; Hasan Ozdemir
Source:
Applied biochemistry and biotechnology 2013 v.170 no.1 pp. 198-209
ISSN:
0273-2289
Subject:
Alzheimer disease; acetylcholinesterase; agarose; cholinesterase; drug therapy; enzyme activity; erythrocytes; gels; humans; hydrolysis; iodides; ionic strength; molecular weight; pH; polyacrylamide gel electrophoresis; proteins; resins; sulfates; temperature
Abstract:
... The acetylcholinesterase enzyme was purified from human erythrocyte membranes using a simple and effective method in a single step. Tacrine (9-amino-1,2,3,4-tetrahydroacridine) is a well-known drug for the treatment of Alzheimer's disease, which inhibits cholinesterase. We have developed a tacrine ligand affinity resin that is easy to synthesize, inexpensive and selective for acetylcholinesterase. ...
DOI:
10.1007/s12010-013-0177-3
PubMed:
23494216

87. Rubus coreanus Miquel Inhibits Acetylcholinesterase Activity and Prevents Cognitive Impairment in a Mouse Model of Dementia

Author:
Kim Cho Rong; Choi Soo Jung; Oh Seung Sang; Kwon Yoon Kyung; Lee Na Young; Park Gwi Gun; Kim Youn-Jung; Heo Ho Jin; Jun Woo Jin; Park Cheung-Seog; Shin Dong-Hoon
Source:
Journal of medicinal food 2013 v.16 no.9 pp. 785-792
ISSN:
1557-7600
Subject:
Alzheimer disease; Rubus coreanus; acetylcholinesterase; animal models; ethanol; memory; mice
Abstract:
... To find acetylcholinesterase (AChE) inhibitors for the prevention of neurological disorders, such as Alzheimer's disease, ethanol extracts of promising traditional edible Korean plants were tested. Among them, Rubus coreanus Miquel extract exhibited the most significant AChE inhibitory activity. The effect of R. coreanus extract on trimethyltin-induced memory impairment in mice was investigated us ...
DOI:
10.1089/jmf.2012.2663
PubMed:
24044488
PubMed Central:
PMC3778953

88. Therapeutic effect of organoselenium dietary supplementation in a sporadic dementia of Alzheimer's type model in rats

Author:
Simone Pinton; César A. Brüning; Carla E. Sartori Oliveira; Marina Prigol; Cristina Wayne Nogueira
Source:
Journal of nutritional biochemistry 2013 v.24 pp. 311-317
ISSN:
0955-2863
Subject:
Alzheimer disease; acetylcholinesterase; adenosine; animal models; cortex; dietary supplements; energy metabolism; hippocampus; memory; oxidative stress; rats; selenium; streptozotocin; therapeutics; thiols; tyrosine
Abstract:
... It is known that selenium (Se) might play different roles in the progression of Alzheimer's disease (AD), but there is a lack of evidence that proves whether supplementation with Se is beneficial or not for the treatment of AD. Thus, the aim of the current study was to investigate the therapeutic effect of p,p'-methoxyl-diphenyl diselenide [(MeOPhSe)2], an organoselenium compound, against streptoz ...
DOI:
10.1016/j.jnutbio.2012.06.012
PubMed:
22959057

89. The geographic isolation of Leucojum aestivum populations leads to divergation of alkaloid biosynthesis

Author:
Strahil Berkov; Lilija Georgieva; Violeta Kondakova; Francesc Viladomat; Jaume Bastida; Atanas Atanassov; Carles Codina
Source:
Biochemical systematics and ecology 2013 v.46 pp. 152-161
ISSN:
0305-1978
Subject:
Alzheimer disease; Leucojum aestivum; acetylcholinesterase; biosynthesis; chemotypes; gas chromatography; lycorine; mass spectrometry; medicine; mountains; Balearic Islands; Bulgaria; Danube River
Abstract:
... Leucojum aestivum, an industrial source of the acetylcholinesterase inhibitor galanthamine, shows a great chemodiversity in its alkaloid synthesis. Samples from various geographically distinct populations from Bulgaria and the Balearic Islands were studied by GC–MS. The alkaloid pattern of the plants of L. aestivum (subsp. pulchellum) from the Balearic Islands were dominated by crinine type compou ...
DOI:
10.1016/j.bse.2012.10.002

90. A molecular chromatographic approach to study the effects of OH and NO on acetylcholinesterase activity

Author:
Firas Ibrahim; Claire André; Rania Aljhni; Tijani Gharbi; Yves Claude Guillaume
Source:
Journal of Molecular Catalysis. B, Enzymatic 2013 v.94 pp. 136-140
ISSN:
1381-1177
Subject:
Alzheimer disease; acetylcholine; acetylcholinesterase; active sites; binding sites; catalytic activity; chromatography; hydroxyl radicals; immobilized enzymes; nitric oxide; serine proteinases
Abstract:
... Acetylcholinesterase (AChE) is a serine protease that hydrolyzes the neurotransmitter acetylcholine. Here, the effects of hydroxyl radical (OH) and nitric oxide (NO) on AChE activity were studied using a biochromatographic process. The enzyme was immobilized on an ethylenediamine (EDA) monolithic convective interaction media (CIM) disk. The AChE enzymatic mechanism was demonstrated from the chroma ...
DOI:
10.1016/j.molcatb.2013.04.014

91. A review on cholinesterase inhibitors for Alzheimer’s disease

Author:
Preet Anand; Baldev Singh
Source:
Archives of pharmacal research 2013 v.36 no.4 pp. 375-399
ISSN:
0253-6269
Subject:
Alzheimer disease; acetylcholine; acetylcholinesterase; amyloid; brain; cholinesterase inhibitors; coumarin; flavonoids; memory; neurodegenerative diseases
Abstract:
... Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is characterized by the deficits in the cholinergic system and deposition of beta amyloid (Aβ) in the form of neurofibrillary tangles and amyloid plaques. Since the cholinergic system plays an important role in the regulation of learning and memory processes, it has been targetted for the design of anti-Alzheimer’s drugs. Cholines ...
DOI:
10.1007/s12272-013-0036-3

92. Acetylcholinesterase Inhibitory Activity of Uleine from Himatanthus lancifolius

Author:
Cláudia Seidl; Beatriz L. Correia; Andréa E. M. Stinghen; Cid A. M. Santos
Source:
Zeitschrift für Naturforschung 2014 v.65 no.7-8 pp. 440-444
ISSN:
1865-7125
Subject:
Alzheimer disease; Apocynaceae; acetylcholinesterase; colorimetry; ethyl acetate; inhibitory concentration 50; methylene chloride; physostigmine; thin layer chromatography
Abstract:
... Application of acetylcholinesterase (AChE) inhibitors is the primary treatment for Alzheimer’s disease. Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors. The aim of this work was to evaluate Himatanthus lancifolius (Muell. Arg.) Woodson, a Brazilian species of Apocynaceae, and its main indole alkaloid uleine, in order to identify new AChE i ...
DOI:
10.1515/znc-2010-7-804

93. Acetylcholinesterase inhibitors from galbanum, the oleo gum-resin of Ferula gummosa Boiss.

Author:
Hamid-Reza Adhami; Veronika Fitz; Andrea Lubich; Hanspeter Kaehlig; Martin Zehl; Liselotte Krenn
Source:
Phytochemistry letters 2014 v.10 pp. lxxxii
ISSN:
1874-3900
Subject:
Alzheimer disease; Ferula; acetylcholinesterase; active ingredients; herbal medicines; high performance liquid chromatography; inhibitory concentration 50; physostigmine; solid phase extraction; umbelliferones
Abstract:
... Due to the correlation of Alzheimer's disease with a cholinergic deficit, acetylcholinesterase (AChE) inhibitors from herbal drugs or herbal medicinal preparations have gained a lot of scientific interest.In a previous study, several substances with AChE inhibitory activity were detected in galbanum by TLC bioautography and two of them were identified as auraptene and farnesiferol A. The aim of pr ...
DOI:
10.1016/j.phytol.2014.08.023

94. Alkaloid Variability in Leucojum aestivum from Wild Populations

Author:
Liliya Georgievaa; Strahil Berkov; Violeta Kondakova; Jaume Bastida; Francesc Viladomat; Atanas Atanassov; Carles Codina
Source:
Zeitschrift für Naturforschung 2014 v.62 no.9-10 pp. 627-635
ISSN:
1865-7125
Subject:
Alzheimer disease; Leucojum aestivum; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; lycorine; summer; Bulgaria
Abstract:
... Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied s ...
DOI:
10.1515/znc-2007-9-1002

95. Anthocyanins restore behavioral and biochemical changes caused by streptozotocin-induced sporadic dementia of Alzheimer's type

Author:
Jessié M. Gutierres; Fabiano B. Carvalho; Maria Rosa C. Schetinger; Patrícia Marisco; Paula Agostinho; Marília Rodrigues; Maribel A. Rubin; Roberta Schmatz; Cassia R. da Silva; Giana de P. Cognato; Julia G. Farias; Cristiane Signor; Vera M. Morsch; Cinthia M. Mazzanti; Mauricio Bogo; Carla D. Bonan; Roselia Spanevello
Source:
Life sciences 2014 v.96 no.1-2 pp. 7-17
ISSN:
0024-3205
Subject:
Alzheimer disease; Ca2-transporting ATPase; acetylcholinesterase; anthocyanins; anxiety; cerebral cortex; enzyme activity; hippocampus; memory; memory disorders; nitrates; nitrites; nitrogen oxides; rats; receptors; sodium-potassium-exchanging ATPase; streptozotocin; tranquilizers; tritium
Abstract:
... The aim of this study was to analyze if the pre-administration of anthocyanin on memory and anxiety prevented the effects caused by intracerebroventricular streptozotocin (icv-STZ) administration-induced sporadic dementia of Alzheimer's type (SDAT) in rats. Moreover, we evaluated whether the levels of nitrite/nitrate (NOx), Na⁺,K⁺-ATPase, Ca²⁺-ATPase and acethylcholinesterase (AChE) activities in ...
DOI:
10.1016/j.lfs.2013.11.014

96. Assessment of Enzyme Inhibitory and Antioxidant Activities of Lignans from Taxus baccata L.

Author:
Nurgun Kucukboyacı; Ilkay Orhan; Bilge Şener; S. Ahmad Nawaz; M. Iqbal Choudhary
Source:
Zeitschrift für Naturforschung 2014 v.65 no.3-4 pp. 187-194
ISSN:
1865-7125
Subject:
Alzheimer disease; acetylcholinesterase; ions; Taxus baccata; 2,2-diphenyl-1-picrylhydrazyl; iron; linoleate 13S-lipoxygenase; chromatography; pathogenesis; lignans; cholinesterase; chlorogenic acid; antioxidant activity
Abstract:
... Phytochemical investigations of Taxus baccata L. by successive chromatographic methods resulted in the isolation of the lignans lariciresinol (1), taxiresinol (2), 3´-demethylisolariciresinol- 9´-hydroxyisopropylether (3), isolariciresinol (4), and 3-demethylisolariciresinol (5) as well as taxoids. Compounds 1 - 5 were evaluated for their acetylcholinesterase (AChE), butyrylcholinesterase (BChE), ...
DOI:
10.1515/znc-2010-3-404

97. Chemical composition, antioxidant and anticholinesterase activity of Melissa officinalis

Author:
Romaiana Picada Pereira; Aline Augusti Boligon; André Storti Appel; Roselei Fachinetto; Carla Speroni Ceron; José Eduardo Tanus-Santos; Margareth Linde Athayde; João Batista Teixeira Rocha
Source:
Industrial crops and products 2014 v.53 pp. 34-45
ISSN:
0926-6690
Subject:
Alzheimer disease; Melissa officinalis; acetylcholinesterase; antioxidant activity; antioxidants; autoxidation; brain; chemical composition; enzyme inhibitors; epinephrine; ethyl acetate; flavonoids; gallic acid; gas chromatography-mass spectrometry; gelatinase A; high performance liquid chromatography; nuclear magnetic resonance spectroscopy; oxidative stress; thiobarbituric acid-reactive substances
Abstract:
... Oxidative stress is associated with various diseases, in particular those related with the central nervous system, such as Alzheimer's disease. Based on the various benefits of Melissa officinalis, we investigated the chemical composition and antioxidant activity of different fractions from M. officinalis extract. Furthermore, the fraction with the highest antioxidant activity was tested as a pote ...
DOI:
10.1016/j.indcrop.2013.12.007

98. Chemical constituents and their acetyl cholinesterase inhibitory and antioxidant activities from leaves of Acanthopanax henryi: potential complementary source against Alzheimer’s disease

Author:
Xiao Dan Zhang; Xiang Qian Liu; Yang Hee Kim; Wan Kyunn Whang
Source:
Archives of pharmacal research 2014 v.37 no.5 pp. 606-616
ISSN:
0253-6269
Subject:
Alzheimer disease; Eleutherococcus; acetylcholinesterase; allopurinol; antioxidant activity; ascorbic acid; chemical composition; free radical scavengers; herbal medicines; high performance liquid chromatography; leaves; medicinal plants; metabolites; quercetin; superoxide anion
Abstract:
... The aim of this study was to investigate chemical constituents of the leaves of Acanthopanax henryi, and their antioxidant, acetyl cholinesterase inhibitory activities. Caffeoyl quinic acid derivates and flavonoids were obtained from A. henry, through column chromatography technologies, and the content of major constituents was determined by the HPLC–UV method. Anti-oxidant activity of the isolate ...
DOI:
10.1007/s12272-013-0252-x

99. Cholinesterase inhibitors from the roots of Harpagophytum procumbens

Author:
Yoon Ho Bae; To Dao Cuong; Tran Manh Hung; Jeong Ah Kim; Mi Hee Woo; Jeong Su Byeon; Jae Sue Choi; Byung Sun Min
Source:
Archives of pharmacal research 2014 v.37 no.9 pp. 1124-1129
ISSN:
0253-6269
Subject:
Alzheimer disease; Harpagophytum procumbens; acetylcholinesterase; cholinesterase; cholinesterase inhibitors; ethyl acetate; medicinal plants; medicinal properties; roots; screening; verbascoside
Abstract:
... Inhibition of cholinesterase has been proposed to be a therapeutic target for the treatment of Alzheimer’s diseases. In our preliminary screening study on the acetylcholinesterase (AChE) inhibitory activity, an ethyl acetate soluble fraction of the roots of Harpagophytum procumbens (Pedaliaceae) was found to inhibit AChE activity at the concentration of 100 μg/mL. Ten compounds (1–10) were isolate ...
DOI:
10.1007/s12272-013-0316-y

100. Comparison of anti-acetylcholinesterase activity of bulb and leaf extracts of Sternbergia candida Mathew & T. Baytop

Author:
M. Z. Haznedaroglu; G. Gokce
Source:
Acta biologica Hungarica 2014 v.65 no.4 pp. 396-404
ISSN:
0236-5383
Subject:
pathophysiology; leaf extracts; Alzheimer disease; lycorine; acetylcholinesterase; methanol; disease prevalence; metabolites; bulbs; cholinesterase inhibitors; cholinesterase; Sternbergia; chloroform; leaves
Abstract:
... Studies on Alzheimer’s disease have been highlighted due to increasing prevalence of this disease. Oldest hypothesis about the pathophysiology strengthens the research of cholinesterase inhibitors for treatment. Amaryllidaceae plants are well known for alkaloids showing cholinesterase inhibiting activity. Among them, Sternbergia species gained attention as a source of metabolites of these a ...
DOI:
10.1556/ABiol.65.2014.4.4