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You searched for: Subject Alzheimer disease Remove constraint Subject: Alzheimer disease Subject bulbs Remove constraint Subject: bulbs Subject term Leucojum aestivum Remove constraint Subject term: Leucojum aestivum Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. Development and validation of a GC–MS method for rapid determination of galanthamine in Leucojum aestivum and Narcissus ssp.: A metabolomic approach

Author:
Strahil Berkov; Jaume Bastida; Francesc Viladomat; Carles Codina
Source:
Talanta 2011 v.83 no.5 pp. 1455-1465
ISSN:
0039-9140
Subject:
Alzheimer disease; Leucojum aestivum; Narcissus; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; high performance liquid chromatography; leaves; metabolomics; methanol; nuclear magnetic resonance spectroscopy; pharmaceutical industry; principal component analysis; quality control; rapid methods; raw materials
Abstract:
... Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt for the treatment of Alzheimer's disease, is obtained from some Amaryllidaceae plants. A new method was developed and validated for its quantification by GC–MS in different plant sources: bulbs and leaves from Narcissus confusus; bulbs from N. pseudonarcissus cv. Carlton; and leaves and in vitro cultures from L. aestiv ...
DOI:
10.1016/j.talanta.2010.11.029

2. Influence of auxins on somatic embryogenesis and alkaloid accumulation in Leucojum aestivum callus

Author:
Agata Ptak; Anna Tahchy; Edyta Skrzypek; Tomasz Wójtowicz; Dominique Laurain-Mattar
Source:
Open life sciences 2013 v.8 no.6 pp. 591-599
ISSN:
2391-5412
Subject:
2,4-D; Alzheimer disease; Leucojum aestivum; alkaloids; auxins; bulbs; callus; callus culture; dicamba; explants; growing media; phenolic compounds; picloram; polyethylene glycol; somatic embryogenesis
Abstract:
... In vitro cultures of Leucojum aestivum are considered as an alternative for the production of galanthamine, which is used for the symptomatic treatment of Alzheimer’s disease. We studied the effects of auxins 2,4-dichlorophenoxyacetic acid (2,4-D), 4-amino-3,5,6-trichloropicolinic acid (picloram), 3,6-dichloro-o-anisic acid (dicamba) at concentrations of 25 and 50 µM on the induction of embryogeni ...
DOI:
10.2478/s11535-013-0160-y

3. Alkaloid Variability in Leucojum aestivum from Wild Populations

Author:
Liliya Georgievaa; Strahil Berkov; Violeta Kondakova; Jaume Bastida; Francesc Viladomat; Atanas Atanassov; Carles Codina
Source:
Zeitschrift für Naturforschung 2014 v.62 no.9-10 pp. 627-635
ISSN:
1865-7125
Subject:
Alzheimer disease; Leucojum aestivum; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; lycorine; summer; Bulgaria
Abstract:
... Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied s ...
DOI:
10.1515/znc-2007-9-1002

4. Enhancement of alkaloid content (galanthamine and lycorine) and antioxidant activities (enzymatic and non-enzymatic) unders salt stress in summer snowflake (Leucojum aestivum L.)

Author:
Muhammed Tural Ates; Arzu Birinci Yildirim; Arzu Ucar Turker
Source:
South African journal of botany 2021 v.140 pp. 182-188
ISSN:
0254-6299
Subject:
Alzheimer disease; Leucojum aestivum; antimalarials; antioxidant activity; bioactive compounds; bulbs; catalase; free radicals; growth and development; lycorine; methanol; salt stress; salt tolerance; summer; superoxide dismutase; water content
Abstract:
... Summer snowflake (Leucojum aestivum L.) is a bulbous plant to the Amaryllidaceae family. L. aestivum is a Euro-Mediterranean region plant and is a well-known source of pharmacologically important alkaloids. Galanthamine is the major bioactive compound that is widely used in the treatment of neurological disorders, including Alzheimer's disease. Another alkaloid lycorine has antitumor, antimalarial ...
DOI:
10.1016/j.sajb.2021.04.016