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You searched for: Subject Alzheimer disease Remove constraint Subject: Alzheimer disease Subject term Bulgaria Remove constraint Subject term: Bulgaria Subject term Leucojum aestivum Remove constraint Subject term: Leucojum aestivum
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1. Alkaloid Variability in Leucojum aestivum from Wild Populations

Author:
Liliya Georgievaa; Strahil Berkov; Violeta Kondakova; Jaume Bastida; Francesc Viladomat; Atanas Atanassov; Carles Codina
Source:
Zeitschrift für Naturforschung 2014 v.62 no.9-10 pp. 627-635
ISSN:
1865-7125
Subject:
Alzheimer disease; Leucojum aestivum; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; lycorine; summer; Bulgaria
Abstract:
... Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied s ...
DOI:
10.1515/znc-2007-9-1002

2. The geographic isolation of Leucojum aestivum populations leads to divergation of alkaloid biosynthesis

Author:
Strahil Berkov; Lilija Georgieva; Violeta Kondakova; Francesc Viladomat; Jaume Bastida; Atanas Atanassov; Carles Codina
Source:
Biochemical systematics and ecology 2013 v.46 pp. 152-161
ISSN:
0305-1978
Subject:
Alzheimer disease; Leucojum aestivum; acetylcholinesterase; biosynthesis; chemotypes; gas chromatography; lycorine; mass spectrometry; medicine; mountains; Balearic Islands; Bulgaria; Danube River
Abstract:
... Leucojum aestivum, an industrial source of the acetylcholinesterase inhibitor galanthamine, shows a great chemodiversity in its alkaloid synthesis. Samples from various geographically distinct populations from Bulgaria and the Balearic Islands were studied by GC–MS. The alkaloid pattern of the plants of L. aestivum (subsp. pulchellum) from the Balearic Islands were dominated by crinine type compou ...
DOI:
10.1016/j.bse.2012.10.002