U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Subject CD8-positive T-lymphocytes Remove constraint Subject: CD8-positive T-lymphocytes
Start Over

Search

2,032  Search Results

« Previous | 1 - 100 of 2,032 |
Number of results to display per page

Search Results

1. Adaptive Immune Responses, Immune Escape and Immune-Mediated Pathogenesis during HDV Infection

Author:
Valerie Oberhardt; Maike Hofmann; Robert Thimme; Christoph Neumann-Haefelin
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
CD8-positive T-lymphocytes; HLA antigens; Hepatitis B virus; Hepatitis C virus; Hepatitis delta virus; Human immunodeficiency virus; adaptive immunity; humans; interferons; liver cirrhosis; mixed infection; pathogenesis; satellite viruses; vertebrate viruses
Abstract:
... The hepatitis delta virus (HDV) is the smallest known human virus, yet it causes great harm to patients co-infected with hepatitis B virus (HBV). As a satellite virus of HBV, HDV requires the surface antigen of HBV (HBsAg) for sufficient viral packaging and spread. The special circumstance of co-infection, albeit only one partner depends on the other, raises many virological, immunological, and pa ...
DOI:
10.3390/v14020198

2. Antitumor efficacy of MUC1-derived variable epitope library treatments in a mouse model of breast cancer

Author:
Josué Odales; Rodolfo Servín-Blanco; Fernando Martínez-Cortés; Jesus Guzman Valle; Allan Noé Domínguez-Romero; Goar Gevorkian; Karen Manoutcharian
Source:
Vaccine 2022 v.40 no.33 pp. 4796-4805
ISSN:
0264-410X
Subject:
CD8-positive T-lymphocytes; breast neoplasms; epitopes; humans; immune response; lungs; metastasis; mice; mutants; peptides; prognosis; signal peptide; tandem repeat sequences; vaccination; vaccine development; vaccines
Abstract:
... The identification of novel targets for cancer immunotherapy and the development of new vaccine immunogens are subjects of permanent interest. MUC1 is an overexpressed antigen found in most tumors, and its overexpression correlates with poor prognosis. Many attempts to direct the immune response against MUC1 in tumor cells have failed, including several clinical trials. We have previously develope ...
DOI:
10.1016/j.vaccine.2022.06.062

3. Bag it, tag it: ubiquitin ligases and host resistance to Mycobacterium tuberculosis

Author:
Priscila C. Campos; Danielle T. Cunha; Luiz P. Souza-Costa; Michael U. Shiloh; Luis H. Franco
Source:
Trends in microbiology 2022 v.30 no.10 pp. 973-985
ISSN:
0966-842X
Subject:
CD8-positive T-lymphocytes; Mycobacterium tuberculosis; anti-infective agents; apoptosis; autophagy; cytokines; enzyme activity; etiological agents; inflammation; lipids; microbiology; phagocytosis; phagosomes; tuberculosis; ubiquitin; ubiquitin-protein ligase; ubiquitination
Abstract:
... Infection with Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), remains a significant global epidemic. Host resistance to Mtb depends on both adaptive and innate immunity mechanisms, including development of antigen-specific CD4 and CD8 T cells, production of inflammatory cytokines, bacterial phagocytosis and destruction within phagolysosomes, host cell apoptosis, and ...
DOI:
10.1016/j.tim.2022.03.010

4. Bioactive fish collagen peptides weaken intestinal inflammation by orienting colonic macrophages phenotype through mannose receptor activation

Author:
Mouna Rahabi; Marie Salon; Christelle Bruno-Bonnet; Mélissa Prat; Godefroy Jacquemin; Khaddouj Benmoussa; Mohamad Alaeddine; Mélissa Parny; José Bernad; Bénédicte Bertrand; Yannick Auffret; Pascale Robert-Jolimaître; Laurent Alric; Hélène Authier; Agnès Coste
Source:
European journal of nutrition 2022 v.61 no.4 pp. 2051-2066
ISSN:
1436-6207
Subject:
CD8-positive T-lymphocytes; antioxidants; chemiluminescence; colitis; collagen; cytokines; dextran; fish; flow cytometry; functional foods; humans; immunomodulation; inflammation; intestinal microorganisms; intestines; macrophages; mannose; monocytes; myeloperoxidase; phenotype; sodium sulfate
Abstract:
... PURPOSE: Particular interest is now given to the potential of dietary supplements as alternative non-pharmacological approaches in intestinal inflammation handling. In this aim, this study evaluates the efficiency of fish collagen peptides, Naticol®Gut, on colonic inflammation. METHODS: Wild type and Mannose receptor-deficient in the myeloid lineage C57BL/6 mice were administered with Dextran Sodi ...
DOI:
10.1007/s00394-021-02787-7

5. CD4+ and CD8+ T-cell responses in bone marrow to fatty acids in high-fat diets

Author:
Mayte Medrano; Ana Lemus-Conejo; Sergio Lopez; Maria C. Millan-Linares; Maria A. Rosillo; Manuel Muñiz; Rocio Calderon; Sara Jaramillo; Jose A. Perez-Simon; Francisco J.G. Muriana; Rocio Abia
Source:
Journal of nutritional biochemistry 2022 v.107 pp. 109057
ISSN:
0955-2863
Subject:
CD8-positive T-lymphocytes; adaptive immunity; bone marrow; docosahexaenoic acid; eicosapentaenoic acid; obesity; oleic acid; spleen
Abstract:
... Obesity is associated with disruptions in the adaptive immune system; however, dietary fatty acids in high-fat diets (HFDs) that induce obesity have consequences that are currently unclear regarding T-cell maintenance in bone marrow (BM). C57BL/6J mice were randomly assigned to isocaloric HFDs formulated with dietary fats rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), o ...
DOI:
10.1016/j.jnutbio.2022.109057

6. CD8 as co-receptor: Not just the TCR

Author:
Jie Geng; Malini Raghavan
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; cell adhesion; education; humans; immunological synapse; major histocompatibility complex
Abstract:
... CD8αβ is a co-receptor for the T cell receptor (TCR), and is classically known to bind to the same cognate peptide-loaded major histocompatibility complex class I molecules (pMHC-I) as the TCR, thus enabling or augmenting T cell responses. Our recent findings show that peptide-deficient forms of MHC class I bind CD8 with high affinity. While peptide-deficient conformers of HLA-B*35:01 did not dire ...
DOI:
10.1016/j.molimm.2022.05.115

7. Cell-associated HIV cross-presentation by pDC is potentiated by non-cognate CD8+ T cell pre-activation

Author:
E.X. Hatton; S. Isnard; M. Iannetta; J-B. Guillerme; A. Hosmalin
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; HIV infections; apoptosis; cytokines; flow cytometry; humans; secretion
Abstract:
... Antigens (Ag) from apoptotic HIV-infected cells can be cross-presented by human plasmacytoid dendritic cells (pDC) to CD8⁺ T cells¹. We studied the mechanisms leading to this cross-presentation. For this, we generated HLA-A2-restricted HIV-Gag-specific CD8⁺ T cell clones. HLA-A2 negative, HIV-infected or uninfected, H9 cells were used as Ag donor cells. They were irradiated by UV-C to induce apopt ...
DOI:
10.1016/j.molimm.2022.05.107

8. Characterization of humoral and cell-mediated immunity induced by mRNA vaccines expressing influenza hemagglutinin stem and nucleoprotein in mice and nonhuman primates

Author:
Jessica A. Flynn; Teresa Weber; Pedro J. Cejas; Kara S. Cox; Sinoeun Touch; Lauren A. Austin; Yangsi Ou; Michael P. Citron; Bin Luo; Marian E. Gindy; Kapil Bahl; Giuseppe Ciaramella; Amy S. Espeseth; Lan Zhang
Source:
Vaccine 2022 v.40 no.32 pp. 4412-4423
ISSN:
0264-410X
Subject:
CD8-positive T-lymphocytes; Orthomyxoviridae; blood serum; cell-mediated immunity; cytotoxicity; hemagglutinins; immune response; immunogenicity; influenza; mice; morbidity; nucleoproteins; seroprevalence; vaccination; vaccines
Abstract:
... In response to immune pressure, influenza viruses evolve, producing drifted variants capable of escaping immune recognition. One strategy for inducing a broad-spectrum immune response capable of recognizing multiple antigenically diverse strains is to target conserved proteins or protein domains. To that end, we assessed the efficacy and immunogenicity of mRNA vaccines encoding either the conserve ...
DOI:
10.1016/j.vaccine.2022.03.063

9. Characterization of the cell-mediated immune response to Takeda’s live-attenuated tetravalent dengue vaccine in adolescents participating in a phase 2 randomized controlled trial conducted in a dengue-endemic setting

Author:
Vianney Tricou; Raphael Gottardo; Michael A. Egan; Frédéric Clement; Geert Leroux-Roels; Xavier Sáez-Llorens; Astrid Borkowski; Derek Wallace; Hansi J. Dean
Source:
Vaccine 2022 v.40 no.8 pp. 1143-1151
ISSN:
0264-410X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; cell-mediated immunity; cross reaction; dengue; flow cytometry; interleukin-2; live vaccines; serotypes; Panama
Abstract:
... As robust dengue-specific CD4+ and CD8+ T cell responses are essential for protective immunity, we assessed cell-mediated immune (CMI) responses to a DENV-2-based dengue tetravalent vaccine candidate (TAK-003) in adolescents living in Panama, a dengue-endemic country. Peripheral blood mononuclear cells were collected from a subset of 67 participants ≥ 10 years old included in a phase 2 clinical tr ...
DOI:
10.1016/j.vaccine.2022.01.016

10. Complete genome sequencing and evolutionary analysis of hepatitis C virus subtype 6a, including strains from Guangdong Province, China

Author:
Ru Xu; Hao Wang; Jieting Huang; Min Wang; Qiao Liao; Zhengang Shan; Huishan Zhong; Xia Rong; Yongshui Fu
Source:
Archives of virology 2022 v.167 no.2 pp. 591-596
ISSN:
0304-8608
Subject:
CD8-positive T-lymphocytes; Hepatitis C virus; epitopes; genome; nucleotide sequences; virology; viruses; China; Vietnam
Abstract:
... We performed an evolutionary analysis using whole genome sequence isolates of hepatitis C virus (HCV) 6a from Guangdong Province and reference sequences from various countries. Less than 5% of the HCV genome was found to be under positive selection. The E1 and E2 proteins had the highest proportion of positively selected sites both within and outside of CD8 T cell epitopes in all of the strains. R ...
DOI:
10.1007/s00705-021-05358-7

11. Constitutive immunoproteasome processing of cytomegalovirus antigenic peptides determines their capacity for memory inflation and immune protection

Author:
Luka Cicin-Sain
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; Cytomegalovirus; Murid betaherpesvirus 1; coculture; epitopes; genes; inflation; memory; peptides; phenotype; proteasome endopeptidase complex; viruses
Abstract:
... Cytomegalovirus antigenic epitopes are marked by a stark duality of outcomes - some induce conventional responses, marked by immune contraction and maintenance of central memory cells; other induce a life-long inflation of antigen-specific CD8 T-cells with effector phenotypes. Similarly, only some epitopes induce protective responses. We set to identify the role of proteasomal processing in this p ...
DOI:
10.1016/j.molimm.2022.05.099

12. CooperationSplenic CD169+ marginal zone macrophages directly cross-prime CD8+ T cells in vivo using a vacuolar processing pathway

Author:
Peter van Endert; François-Xavier Mauvais; Yamina Hamel; Julien Diana; Meriem Garfa
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; antigens; gene expression; macrophages; memory; microscopy; phenotype; proteasome endopeptidase complex; pulp; vacuoles
Abstract:
... Cross-priming of CD8+ T cells is of critical importance in triggering CD8+ T cell responses against pathogens and tumors. It is commonly thought that conventional type 1 dendritic cells (cDC1) cross-prime with unequalled efficacy, conferred to them by a proteasome and TAP-dependent pathway. Here we present data challenging the unique cross-priming efficacy of both the cDC1 subset and the proteasom ...
DOI:
10.1016/j.molimm.2022.05.112

13. Cross presentation: more exotic pathwaysEpigenetic repression of MHC class I antigen presentation enables immune evasion in cancer

Author:
Marian Burr; Christina Sparbier; Kah Lok Chan; Paul Lehner; Kate Sutherland; Mark Dawson
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; CRISPR-Cas systems; Sarcophilus harrisii; antigen presentation; antigens; epigenetics; genome; immune evasion; immunotherapy; lung neoplasms; mice; models; monitoring; transcription (genetics)
Abstract:
... Loss of MHC class I antigen presentation in cancer cells is a frequent cause of primary and acquired resistance to immunotherapy. Using a genome wide CRISPR/Cas9 screen we identify a highly conserved epigenetic repressive complex that mediates the coordinated transcriptional silencing of the MHC class I antigen processing and presentation pathway in a range of cancers, promoting immune evasion. Di ...
DOI:
10.1016/j.molimm.2022.05.060

14. Current Understanding of the Role of T Cells in Chikungunya, Dengue and Zika Infections

Author:
Maheshi Mapalagamage; Daniela Weiskopf; Alessandro Sette; Aruna Dharshan De Silva
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
B-lymphocytes; CD8-positive T-lymphocytes; burden of disease; cross reaction; cytokines; dengue; epitopes; humans; lymph; protective effect; vaccines
Abstract:
... Arboviral infections such as Chikungunya (CHIKV), Dengue (DENV) and Zika (ZIKV) are a major disease burden in tropical and sub-tropical countries, and there are no effective vaccinations or therapeutic drugs available at this time. Understanding the role of the T cell response is very important when designing effective vaccines. Currently, comprehensive identification of T cell epitopes during a D ...
DOI:
10.3390/v14020242

15. Development of an immunogen containing CD4+/CD8+ T-cell epitopes for the prophylaxis of tegumentary leishmaniasis

Author:
Isabela de Andrade Ferraz; Ana Maria Ravena Severino Carvalho; Rory Cristiane Fortes de Brito; Bruno Mendes Roatt; Vívian Tamietti Martins; Daniela Pagliara Lage; Luiza dos Reis Cruz; Fernanda Alvarenga Cardoso Medeiros; Denise Utsch Gonçalves; Manoel Otávio da Costa Rocha; Eduardo Antonio Ferraz Coelho; Tiago Antônio de Oliveira Mendes; Mariana Costa Duarte; Daniel Menezes-Souza
Source:
Applied microbiology and biotechnology 2022 v.106 no.12 pp. 4627-4641
ISSN:
0175-7598
Subject:
CD8-positive T-lymphocytes; Leishmania braziliensis; adjuvants; biomarkers; biotechnology; disease prevention; epitopes; etiological agents; genes; immunization; immunoinformatics; leishmaniasis; memory; mice; microbiology; models; parasites; recombinant fusion proteins; toxicity; vaccine development; vaccines; Brazil
Abstract:
... Tegumentary leishmaniasis (TL) is a disease of high severity and incidence in Brazil, and Leishmania braziliensis is its main etiological agent. The inefficiency of control measures, such as high toxicity and costs of current treatments and the lack of effective immunoprophylactic strategies, makes the development of vaccines indispensable and imminent. In this light, the present work developed a ...
DOI:
10.1007/s00253-022-12033-7

16. Distinct Plasma Concentrations of Acyl-CoA-Binding Protein (ACBP) in HIV Progressors and Elite Controllers

Author:
Stéphane Isnard; Léna Royston; John Lin; Brandon Fombuena; Simeng Bu; Sanket Kant; Tsoarello Mabanga; Carolina Berini; Mohamed El-Far; Madeleine Durand; Cécile L. Tremblay; Nicole F. Bernard; Guido Kroemer; Jean-Pierre Routy
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
CD8-positive T-lymphocytes; acyl coenzyme A; antiretroviral agents; autophagy; interleukin-6; interleukin-8; people; therapeutics; virus replication
Abstract:
... HIV elite controllers (ECs) are characterized by the spontaneous control of viral replication, and by metabolic and autophagic profiles which favor anti-HIV CD4 and CD8 T-cell responses. Extracellular acyl coenzyme A binding protein (ACBP) acts as a feedback inhibitor of autophagy. Herein, we assessed the circulating ACBP levels in ECs, compared to people living with HIV (PLWH) receiving antiretro ...
DOI:
10.3390/v14030453

17. ECTV-encoded protein C15 restricts CD4+ T cell activation

Author:
Katherine Forsyth; Nathan Roy; Devin Fisher; Adam Hersperger; Janis Burkhardt; Laurence Eisenlohr
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Orthopoxvirus; antigens; coevolution; disease progression; mechanism of action; peptides; smallpox; synapse; virulence; virus replication
Abstract:
... Orthopoxviruses encode many immunomodulatory proteins that profoundly interfere with various aspects of the immune system. Ectromelia (ECTV) is the orthopoxvirus that naturally infects mice, affording the opportunity to study viral-host interactions that have co-evolved. Importantly, disease progression closely mimics that of monkeypox and smallpox in humans. CD4+ T cells are crucial for the contr ...
DOI:
10.1016/j.molimm.2022.05.086

18. The Effect of Arginase on Canine T-Lymphocyte Functions and its Modulation by All-Trans Retinoid Acid (ATRA) in Canine Monocyte-Derived Macrophages

Author:
Aimee M. Soileau; Cally N. Quick; Cambri E. Moeller; Jessica C. Schaumburg; Sita S. Withers
Source:
Veterinary sciences 2022 v.9 no.7 pp. -
ISSN:
2306-7381
Subject:
CD8-positive T-lymphocytes; arginase; dogs; enzyme-linked immunosorbent assay; flow cytometry; immunosuppression; interleukin-10; interleukin-6; macrophages; neoplasms; phenotype; retinoic acid; reverse transcriptase polymerase chain reaction
Abstract:
... Immunosuppressive myeloid cells in the tumor microenvironment play a major role in suppressing tumor immunity via the production of arginase, IL-10, and others. The objectives of this study were to determine the ability of all-trans retinoic acid (ATRA) to decrease the expression of arginase and other soluble mediators by canine monocyte-derived macrophages (MDMs) and to determine the inhibitory a ...
DOI:
10.3390/vetsci9070374

19. Effectiveness of Booster Doses of the SARS-CoV-2 Inactivated Vaccine KCONVAC against the Mutant Strains

Author:
Chanchan Xiao; Jun Su; Chanjuan Zhang; Boya Huang; Lipeng Mao; Zhiyao Ren; Weibin Bai; Huayu Li; Guomin Lei; Jingshan Zheng; Guobing Chen; Xiaofeng Liang; Congling Qiu
Source:
Viruses 2022 v.14 no.9 pp. -
ISSN:
1999-4915
Subject:
CD8-positive T-lymphocytes; Lota; Severe acute respiratory syndrome coronavirus 2; cell-mediated immunity; mutants; secondary immunization; vaccines
Abstract:
... As the COVID-19 epidemic progresses with the emergence of different SARS-CoV-2 variants, it is important to know the effectiveness of inactivated SARS-CoV-2 vaccines against the variants. To maximize efficiency, a third boost injection of the high-dose SARS-CoV-2 inactivated vaccine KCONVAC was selected for investigation. In addition to the ancestral strain, KCONVAC boost vaccination induced neutr ...
DOI:
10.3390/v14092016

20. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope

Author:
Garry Dolton; Cristina Rius; Md Samiul Hasan; Aaron Wall; Barbara Szomolay; Enas Behiry; Thomas Whalley; Joel Southgate; Anna Fuller; Théo Morin; Katie Topley; Li Rong Tan; Philip J.R. Goulder; Owen B. Spiller; Pierre J. Rizkallah; Lucy C. Jones; Thomas R. Connor; Andrew K. Sewell; The COVID-19 Genomics UK (COG-UK) consortium
Source:
Cell 2022 v.185 no.16 pp. 2936-2951.e19
ISSN:
0092-8674
Subject:
CD8-positive T-lymphocytes; HLA antigens; Severe acute respiratory syndrome coronavirus 2; cytotoxicity; epitopes; immunity; mutation; vaccines
Abstract:
... We studied the prevalent cytotoxic CD8 T cell response mounted against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein₂₆₉₋₂₇₇ epitope (sequence YLQPRTFLL) via the most frequent human leukocyte antigen (HLA) class I worldwide, HLA A∗02. The Spike P272L mutation that has arisen in at least 112 different SARS-CoV-2 lineages to date, including in lineages classified as ...
DOI:
10.1016/j.cell.2022.07.002

21. Eomes and T‐bet, a dynamic duo regulating NK cell differentiation

Author:
Jiang Zhang; Noémi Rousseaux; Thierry Walzer
Source:
BioEssays 2022 v.44 no.3 pp. e2100281
ISSN:
0265-9247
Subject:
CD8-positive T-lymphocytes; DNA; cell differentiation; chromatin; cytotoxicity; epigenetics; gene expression; transcription (genetics)
Abstract:
... T‐bet and Eomes are two related transcription factors (TFs) that regulate the differentiation of cytotoxic lymphocytes such as Natural Killer (NK) cells and CD8 T cells. Recent genome‐wide analyses suggest they have complementary roles in instructing the transcriptional program of NK cells, although their DNA binding sites appear to be very similar. In this essay, we discuss the mechanisms that co ...
DOI:
10.1002/bies.202100281

22. Expression of Id3 represses exhaustion of anti-tumor CD8 T cells in liver cancer

Author:
Yun Jin; Pingping Hu; Haihang Sun; Chao Yang; Jianxin Zhai; Yi Wang; Xinyun Chu; Zhiwei Sun; Jia Wang; Jie Sun; Junfeng Wang
Source:
Molecular immunology 2022 v.144 pp. 117-126
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; DNA; homeostasis; immunology; liver neoplasms; memory
Abstract:
... Id3, an inhibitor of DNA binding protein, plays important roles in the function and homeostasis of effector and memory T cells. Recent evidence has shown that Id3 is also implicated in CD8 T cell exhaustion. However, whether and how Id3 might regulate effector function or exhaustion of CD8 T cells, especially in the tumor setting, is still unknown. Here, we first showed that Id3 expression was imp ...
DOI:
10.1016/j.molimm.2022.02.005

23. Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals

Author:
Katlyn Lederer; Emily Bettini; Kalpana Parvathaneni; Mark M. Painter; Divyansh Agarwal; Kendall A. Lundgreen; Madison Weirick; Kavitha Muralidharan; Diana Castaño; Rishi R. Goel; Xiaoming Xu; Elizabeth M. Drapeau; Sigrid Gouma; Jordan T. Ort; Moses Awofolaju; Allison R. Greenplate; Carole Le Coz; Neil Romberg; Jennifer Trofe-Clark; Gregory Malat; Lisa Jones; Mark Rosen; Daniela Weiskopf; Alessandro Sette; Behdad Besharatian; Mary Kaminiski; Scott E. Hensley; Paul Bates; E. John Wherry; Ali Naji; Vijay Bhoj; Michela Locci
Source:
Cell 2022 v.185 no.6 pp. 1008-1024.e15
ISSN:
0092-8674
Subject:
B-lymphocytes; CD8-positive T-lymphocytes; Severe acute respiratory syndrome coronavirus 2; humans; kidney transplant; lymph; lymph nodes; memory; vaccination
Abstract:
... Vaccine-mediated immunity often relies on the generation of protective antibodies and memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth comparison of the GC responses elicited by SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals has not yet been performed due to the challenge of directly probing human lymph nodes. Herein, through a fine-needle ...
DOI:
10.1016/j.cell.2022.01.027

24. Global Overview of Sars-Cov-2 Induced Covid-19 In 2020: Biological Characterization, Epidemiology with Social, Economic and Environmental Implications

Author:
Ayesha Batool; Ayesha Kashif; Muhammad Haq Nawaz; Ashfaq Ahmad Khan; Nafees Iqbal; Muhammad Kashif Shahid
Source:
RADS journal of biological research & applied science 2022 v.13 no.1 pp. -
ISSN:
2521-8573
Subject:
CD8-positive T-lymphocytes; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; adrenal cortex hormones; antibiotics; environmental impact; etiological agents; genome; herd immunity; mortality; nose; oxygen; pandemic; pharynx; protein subunits; research; society; vaccination; viruses
Abstract:
... Background: COVID-19 is a global pandemic initiated in January 2020 that caused 79 million cases and more than 1.7 million deaths worldwide. The causative agent of COVID-19 is Severe Acute Respiratory Syndrome Coronavirus-2, a member of Betacoronvirus. COVID-19 patients are classified into asymptomatic, mild symptomatic, and severe symptomatic cases. Objectives: To review the prevalence, therapeut ...
DOI:
10.37962/jbas.v13i1.391

25. Healthy myeloid-derived suppressor cells express the surface ectoenzyme Vanin-2 (VNN2)

Author:
David C. Soler; Amber Kerstetter-Fogle; Andrew B. Young; Pat Rayman; James H. Finke; Sarah M. Debanne; Kevin D. Cooper; Jill Barnholtz-Sloan; Andrew E. Sloan; Thomas S. McCormick
Source:
Molecular immunology 2022 v.142 pp. 1-10
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; biomarkers; cell proliferation; glioma; humans; immunology; microarray technology; monocytes; phenotype
Abstract:
... Study of human monocytic Myeloid-Derived Suppressor cells Mo-MDSC (CD14⁺ HLA-DRⁿᵉᵍ/ˡᵒʷ) has been hampered by the lack of positive cell-surface markers. In order to identify positive markers for Mo-MDSC, we performed microarray analysis comparing Mo-MDSC cells from healthy subjects versus CD14⁺ HLA-DRʰⁱᵍʰ monocytes. We have identified the surface ectoenzyme Vanin-2(VNN2) protein as a novel biomarke ...
DOI:
10.1016/j.molimm.2021.12.011

26. Heterogenous CD8+ T Cell Maturation and ‘Polarization’ in Acute and Convalescent COVID-19 Patients

Author:
Igor V. Kudryavtsev; Natalia A. Arsentieva; Zoia R. Korobova; Dmitry V. Isakov; Artem A. Rubinstein; Oleg K. Batsunov; Irina V. Khamitova; Raisa N. Kuznetsova; Tikhon V. Savin; Tatiana V. Akisheva; Oksana V. Stanevich; Aleksandra A. Lebedeva; Evgeny A. Vorobyov; Snejana V. Vorobyova; Alexander N. Kulikov; Maria A. Sharapova; Dmitrii E. Pevtsov; Areg A. Totolian
Source:
Viruses 2022 v.14 no.9 pp. -
ISSN:
1999-4915
Subject:
CD8-positive T-lymphocytes; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; blood serum; flow cytometry; immune response; lungs; memory; patients
Abstract:
... Background. The adaptive antiviral immune response requires interaction between CD8+ T cells, dendritic cells, and Th1 cells for controlling SARS-CoV-2 infection, but the data regarding the role of CD8+ T cells in the acute phase of COVID-19 and post-COVID-19 syndrome are still limited. Methods.. Peripheral blood samples collected from patients with acute COVID-19 (n = 71), convalescent subjects b ...
DOI:
10.3390/v14091906

27. Hierarchy of multiple viral CD8+ T-cell epitope mutations in sequential selection in simian immunodeficiency infection

Author:
Nana Afia Asante Ntim; Hiroshi Ishii; Moe Jomori; Hiroyuki Yamamoto; Tetsuro Matano; Takushi Nomura
Source:
Biochemical and biophysical research communications 2022 v.607 pp. 124-130
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; HIV infections; Simian immunodeficiency virus; disease progression; early selection; epitopes; haplotypes; immunosuppression; major histocompatibility complex; models; mutation; research; virus replication
Abstract:
... CD8⁺ T-cell responses exert strong suppressive pressure on viral replication and select for viral escape mutations in HIV infection. Multiple viral epitopes restricted by major histocompatibility complex class I (MHC-I) are targeted by CD8⁺ T cells. Sequential selection of viral escape mutations in individual epitope-coding regions could result in failure in CD8⁺ T cell-based viral control leading ...
DOI:
10.1016/j.bbrc.2022.03.108

28. Humoral and cellular immune memory response 12 years following single dose vaccination against hepatitis A in Argentinian children

Author:
A. Urueña; M.N. Badano; P. Baré; J. González; R. Vicentín; R. Calli; M.C. Cañero-Velasco; S. Fink; C. Vizzotti
Source:
Vaccine 2022 v.40 no.1 pp. 114-121
ISSN:
0264-410X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Hepatovirus A; antibodies; antigens; flow cytometry; hepatitis A; immunologic memory; memory; vaccination; vaccines; Argentina
Abstract:
... Infants’ universal hepatitis A virus (HAV) single-dose vaccination has been highly effective for controlling HAV infection in Argentina, and in other Latin-American countries that adopted that strategy. Although antibodies wane over time, this has not been associated with HAV outbreaks or breakthrough infections, suggesting a relevant role for memory immunity. This study assessed long term humoral ...
DOI:
10.1016/j.vaccine.2021.11.037

29. IRE1α activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8+ T cell Priming

Author:
Bernardita Medel; Cristobal Costoya; Dominique Fernandez; Fabiola Osorio
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; antigen presentation; antigens; bone marrow; cell proliferation; cytokines; dendritic cells; endoplasmic reticulum; homeostasis; immunotherapy; melanoma; mutants; proteome; ribonucleases; unfolded protein response
Abstract:
... The IRE1α/XBP1s signaling pathway is an arm of the unfolded protein response (UPR) that safe guards the fidelity of the cellular proteome during endoplasmic reticulum (ER) stress. IRE1α has also emerged as a key regulator of dendritic cell (DC) homeostasis where it controls key features including the cross-presentation of dead cell-associated antigens. This aspect is highly applicable to the field ...
DOI:
10.1016/j.molimm.2022.05.065

30. IRFE-mediated regulation of mCMV m152 expression

Author:
Sara Becker; Franziska Blaum; Julia Schmiedeke; Matthias Reddehase; Niels Lemmermann
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; flow cytometry; genes; immune evasion; immunology; loss-of-function mutation; mice; models; promoter regions; protein synthesis; viruses
Abstract:
... Cytomegaloviruses (CMVs) have evolved genes dedicated to subvert literally all components of the host´s immune system. The host in turn has evolved mechanisms to attenuate viral immune evasion to control the virus. The model of murine CMV (mCMV) has been pivotal to the discovery of CMV immune evasion genes and made it feasible to study their roles in vivo. Two of these genes are strong MHC class-I ...
DOI:
10.1016/j.molimm.2022.05.033

31. Icaritin inhibited cigarette smoke extract-induced CD8+ T cell chemotaxis enhancement by targeting the CXCL10/CXCR3 axis and TGF-β/Smad2 signaling

Author:
Qiuping Li; Jing Sun; Yuxue Cao; Baojun Liu; Zhengxiao Zhao; Lingli Hu; Hu Zhang; Qing Kong; Jinfeng Wu; Jingcheng Dong
Source:
Phytomedicine 2022 v.96 pp. 153907
ISSN:
0944-7113
Subject:
CD8-positive T-lymphocytes; RNA; apoptosis; chemotaxis; cigarettes; drugs; lung function; lungs; macrophages; models; respiratory tract diseases; secretion; sequence analysis; smoke; therapeutics
Abstract:
... Chronic obstructive pulmonary disease (COPD) is a disabling/fatal disease characterized by progressive pulmonary function decline, and there are currently few drugs that can effectively reverse the decline in lung function; therefore, it is necessary to find novel drug targets. CD8⁺ T cells might be a new therapeutic target for alleviating lung tissue destruction and improving pulmonary function i ...
DOI:
10.1016/j.phymed.2021.153907

32. Identification of potential immune/diagnosis related gene-immunocyte subtype networks in extracellular immune response to respiratory syncytial virus infection

Author:
Baohong Wang; Hongbo Liu
Source:
Virus research 2022 v.321 pp. 198906
ISSN:
0168-1702
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Respiratory syncytial virus; arachidonic acid; chemokines; dendritic cells; gene expression; gene expression regulation; genes; immune response; metabolism; models; natural killer cells; protein-protein interactions; research; respiratory tract diseases; therapeutics; viruses
Abstract:
... Respiratory syncytial virus (RSV) is one of the important pathogenic agents of pediatric respiratory tract infection. Weighted gene co-expression network analysis (WGCNA) is used to study autoimmune diseases, which can find potential hub genes. The diagnostic model based on hub genes and machine learning makes it possible to diagnose the extracellular immune response to RSV infection early. The ai ...
DOI:
10.1016/j.virusres.2022.198906

33. Identification of promising CD8 and CD4 T cell epitopes for peptide vaccine formulation against SARS-CoV-2

Author:
Supriyo Chakraborty; Bornali Deb; Durbba Nath; Deboja Monoswita
Source:
Archives of microbiology 2022 v.204 no.5 pp. 242
ISSN:
0302-8933
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; adjuvants; amino acids; cost effectiveness; epitopes; glycoproteins; glycosylation; humans; hydrophilicity; immunogenicity; immunoinformatics; membrane glycoproteins; pandemic; peptides; viruses
Abstract:
... The novel virus “severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)” has been responsible for the worldwide pandemic causing huge devastation and deaths since December 2019. The disease caused by this virus is known as COVID-19. The present study is based on immuno-informatics approach to develop a multi-epitope-loaded peptide vaccine to combat the COVID-19 menace. Here, we have reported ...
DOI:
10.1007/s00203-022-02845-6

34. Immunogenic epitope prediction to create a universal influenza vaccine

Author:
R.R. Mintaev; D.V. Glazkova; E.V. Bogoslovskaya; G.A. Shipulin
Source:
Heliyon 2022 v.8 no.5 pp. e09364
ISSN:
2405-8440
Subject:
B-lymphocytes; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Orthomyxoviridae; epitopes; humans; immunity; influenza; influenza vaccines; morbidity; mortality; prediction; viruses
Abstract:
... Influenza virus is one of the most rapidly evolving human pathogens and causes significant morbidity and mortality worldwide. This feature enables the virus to avoid natural or vaccine-induced immunity. For this reason, there is an intensive search for new approaches to create a universal influenza vaccine. Here, we propose pipelines based on modern prediction algorithms that allowed us to select ...
DOI:
10.1016/j.heliyon.2022.e09364

35. Immunoinformatics-based characterization of immunogenic CD8 T-cell epitopes for a broad-spectrum cell-mediated immunity against high-risk human papillomavirus infection

Author:
Alexandre Santos Matos; Fernanda Oliveira Prado; Paloma Aparecida Santos Rocha; Marcus Vinicius Aragão Batista
Source:
Microbial pathogenesis 2022 v.165 pp. 105462
ISSN:
0882-4010
Subject:
CD8-positive T-lymphocytes; Papillomaviridae; cell-mediated immunity; energy; epitopes; humans; hydrogen; immunogenicity; pathogenesis; pathogens; toxicity; vaccination; vaccines
Abstract:
... Human papillomavirus (HPV) represents the most prevalent sexually transmitted infectious agent worldwide. Vaccination has been an approach successfully used as a prophylactic measure against this infectious agent in patients without previous contact with the genotypes present in the vaccine. In this work, we use a computational approach to predict CD8 T cell epitopes from HPV proteins to promote c ...
DOI:
10.1016/j.micpath.2022.105462

36. In silico analysis of mutant epitopes in new SARS-CoV-2 lineages suggest global enhanced CD8+ T cell reactivity and also signs of immune response escape

Author:
Marco Antônio M. Pretti; Rômulo G. Galvani; Nicole M. Scherer; Alessandro S. Farias; Mariana Boroni
Source:
Infection, genetics, and evolution 2022 v.99 pp. 105236
ISSN:
1567-1348
Subject:
CD8-positive T-lymphocytes; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; antibodies; computer simulation; epitopes; evolution; immune response; infection; mutants; nucleocapsid; peptides; viral load; Brazil; South Africa
Abstract:
... SARS-CoV-2 variants of concern have emerged since the COVID-19 outburst, notably the lineages detected in the UK, South Africa, and Brazil. Their increased transmissibility and higher viral load put them in the spotlight. Much has been investigated on the ability of those new variants to evade antibody recognition. However, little attention has been given to pre-existing and induced SARS-CoV-2-spe ...
DOI:
10.1016/j.meegid.2022.105236

37. Increased angiopoietin-like 4 expression ameliorates inflammatory bowel diseases via suppressing CD8+ T cell activities

Author:
Xiaoyuan Zhang; Jing Tu; Shizhen Ding; Mei Wang; Yanbing Ding; Zhijie Lin; Guotao Lu; Weiming Xiao; Weijuan Gong
Source:
Biochemical and biophysical research communications 2022 v.612 pp. 37-43
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; Crohn disease; atherosclerosis; dextran sulfate; macrophages; noninsulin-dependent diabetes mellitus; pathogenesis; protective effect; research; respiratory tract diseases; rheumatoid arthritis; secretion; ulcerative colitis
Abstract:
... Angiopoietin-like 4 (ANGPTL4) is involved in inflammation-associated diseases, such as rheumatoid arthritis, type 2 diabetes, atherosclerosis, and chronic obstructive pulmonary disease. The role of ANGPTL4 in the pathogenesis of inflammatory bowel disease (IBD) remains unknown. Here, the plasma ANGPTL4 levels peaked on days 3 and 5, and expression of ANGPTL4 of inflamed colons peaked on days 5 and ...
DOI:
10.1016/j.bbrc.2022.03.153

38. Keynote Lecture 1A non-canonical pathway of cross-presentation disables self/non-self discrimination

Author:
J. Magarian Blander
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; Mycobacterium tuberculosis; Toll-like receptors; antigen presentation; ligands; malaria; peptides; phagosomes; phosphorylation; synaptosomes
Abstract:
... The classic pathway of MHC class I (MHC-I) presentation by dendritic cells (DC) is critical to initiate immunity against microbial pathogens. For viruses that do not infect DC or when the antigen presentation functions of infected DC have been compromised, cross-presentation ensures the mobilization of an antiviral CD8 T cell response. Cross-presentation is an adaptation of the classical pathway o ...
DOI:
10.1016/j.molimm.2022.05.056

39. Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate

Author:
Swantje Liedmann; Xueyan Liu; Clifford S. Guy; Jeremy Chase Crawford; Diego A. Rodriguez; Duygu Kuzuoğlu-Öztürk; Ao Guo; Katherine C. Verbist; Jamshid Temirov; Mark J. Chen; Davide Ruggero; Hui Zhang; Paul G. Thomas; Douglas R. Green
Source:
Molecular cell 2022 v.82 no.13 pp. 2401-2414.e9
ISSN:
1097-2765
Subject:
CD8-positive T-lymphocytes; polyribosomes; synapse; transcription (genetics)
Abstract:
... Activated CD8⁺ T lymphocytes differentiate into heterogeneous subsets. Using super-resolution imaging, we found that prior to the first division, dynein-dependent vesicular transport polarized active TORC1 toward the microtubule-organizing center (MTOC) at the proximal pole. This active TORC1 was physically associated with active eIF4F, required for the translation of c-myc mRNA. As a consequence, ...
DOI:
10.1016/j.molcel.2022.04.016

40. Magnesium sensing via LFA-1 regulates CD8+ T cell effector function

Author:
Jonas Lötscher; Adrià-Arnau Martí i Líndez; Nicole Kirchhammer; Elisabetta Cribioli; Greta Maria Paola Giordano Attianese; Marcel P. Trefny; Markus Lenz; Sacha I. Rothschild; Paolo Strati; Marco Künzli; Claudia Lotter; Susanne H. Schenk; Philippe Dehio; Jordan Löliger; Ludivine Litzler; David Schreiner; Victoria Koch; Nicolas Page; Dahye Lee; Jasmin Grählert; Dmitry Kuzmin; Anne-Valérie Burgener; Doron Merkler; Miklos Pless; Maria L. Balmer; Walter Reith; Jörg Huwyler; Melita Irving; Carolyn G. King; Alfred Zippelius; Christoph Hess
Source:
Cell 2022 v.185 no.4 pp. 585-602.e29
ISSN:
0092-8674
Subject:
CD8-positive T-lymphocytes; blood serum; calcium; cell-mediated immunity; cytotoxicity; disease progression; magnesium; signal transduction; synapse
Abstract:
... The relevance of extracellular magnesium in cellular immunity remains largely unknown. Here, we show that the co-stimulatory cell-surface molecule LFA-1 requires magnesium to adopt its active conformation on CD8⁺ T cells, thereby augmenting calcium flux, signal transduction, metabolic reprogramming, immune synapse formation, and, as a consequence, specific cytotoxicity. Accordingly, magnesium-suff ...
DOI:
10.1016/j.cell.2021.12.039

41. Memory CD8 T Cells Protect against Cytomegalovirus Disease by Formation of Nodular Inflammatory Foci Preventing Intra-Tissue Virus Spread

Author:
Rafaela Holtappels; Jürgen Podlech; Kirsten Freitag; Niels A. Lemmermann; Matthias J. Reddehase
Source:
Viruses 2022 v.14 no.6 pp. -
ISSN:
1999-4915
Subject:
CD8-positive T-lymphocytes; Cytomegalovirus; cell transplantation; histopathology; immunotherapy; mice; risk; viruses
Abstract:
... Cytomegaloviruses (CMVs) are controlled by innate and adaptive immune responses in an immunocompetent host while causing multiple organ diseases in an immunocompromised host. A risk group of high clinical relevance comprises transiently immunocompromised recipients of hematopoietic cell transplantation (HCT) in the “window of risk” between eradicative therapy of hematopoietic malignancies and comp ...
DOI:
10.3390/v14061145

42. Most viral peptides displayed by class I MHC on infected cells are immunogenic

Author:
Nathan Croft; Stewart Smith; John Sidney; Bjoern Peters; Pouya Faridi; Matthew Witney; Alex Sette; Nicole La Gruta; Anthony Purcell; David Tscharke
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; Vaccinia virus; epitopes; fibroblasts; immunogenicity; mass spectrometry; mice; peptides; splenocytes; viruses
Abstract:
... CD8+ T cells are essential effectors in antiviral immunity, recognizing short virus-derived peptides presented by MHC class I (pMHCI) on the surface of infected cells. However, the fraction of viral pMHCI on infected cells that are immunogenic has not been shown for any virus. To approach this fundamental question, we used peptide sequencing by high-resolution mass spectrometry to identify more th ...
DOI:
10.1016/j.molimm.2022.05.034

43. Mucormycosis co-infection in COVID-19 patients: An update

Author:
Abdullah S. Alkhamiss; Ahmed A. Ahmed; Zafar Rasheed; Ruqaih Alghsham; Ali Shariq; Thamir Alsaeed; Sami A. Althwab; Suliman Alsagaby; Abdullah S. M. Aljohani; Fahad A. Alhumaydhi; Sharifa K. Alduraibi; Alaa K. Alduraibi; Homaidan T. Alhomaidan; Khaled S. Allemailem; Raya A. Alharbi; Samar A. Alamro; Arwa M. Alqusayer; Sahim A. Alharbi; Thekra A. Alharby; Mona S. Almujaydil; Ayman M. Mousa; Sultan A. Alghaniam; Abdulrhman A. Alghunaim; Rana Alghamdi; Nelson Fernández; Waleed Al Abdulmonem
Source:
Open life sciences 2022 v.17 no.1 pp. 917-937
ISSN:
2391-5412
Subject:
CD8-positive T-lymphocytes; COVID-19 infection; adrenal cortex hormones; debridement; diabetes; ferritin; fungi; heme oxygenase (biliverdin-producing); iron absorption; ketosis; metabolism; mixed infection; phagocytosis; transferrin; zygomycosis
Abstract:
... Mucormycosis (MCM) is a rare fungal disorder that has recently been increased in parallel with novel COVID-19 infection. MCM with COVID-19 is extremely lethal, particularly in immunocompromised individuals. The collection of available scientific information helps in the management of this co-infection, but still, the main question on COVID-19, whether it is occasional, participatory, concurrent, o ...
DOI:
10.1515/biol-2022-0085

44. Multiparametric approach to assess the disease severity and progression of cutaneous leishmaniasis infection

Author:
Shumaila Naz; Aiman Aroosh; Naeem Raza; Arshad Islam; Yusuf Ozbel; Seray Toz; Haroon Ahmed; Shahid Waseem
Source:
Acta tropica 2022 v.235 pp. 106659
ISSN:
0001-706X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Leishmania major; Leishmania tropica; biomarkers; cutaneous leishmaniasis; disease progression; disease severity; immune response; interleukin-4; mitochondrial DNA; pathophysiology
Abstract:
... The pathophysiology of Cutaneous Leishmaniasis (CL), an infection caused by Leishmania tropica (L. tropica) and Leishmania major (L. major) is primarily determined by inflammation-mediated immune cells. The immune response mainly depends on cells and molecules related to T-cells that influence susceptibility and disease development. Understanding the immunological mechanisms that cause tissue inju ...
DOI:
10.1016/j.actatropica.2022.106659

45. Normal weight obesity is associated with hypercholesterolemia and low muscle mass in persons living with HIV on antiretroviral treatment

Author:
Ivan A. Osuna-Padilla; Nadia C. Rodríguez-Moguel; Adriana Aguilar-Vargas; Edna Rodríguez-Aguirre; Olivia Briceño; Santiago Ávila-Ríos
Source:
Nutrition 2022 v.94 pp. 111515
ISSN:
0899-9007
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; adults; antiretroviral agents; blood glucose; blood pressure; body fat; body mass index; bone density; cholesterol; clinical examination; dual-energy X-ray absorptiometry; high density lipoprotein; hypercholesterolemia; inflammation; interleukin-6; low density lipoprotein; morbidity; muscle tissues; necrosis; neoplasms; nutrition; obesity; triacylglycerols
Abstract:
... Objectives: Normal weight obesity (NWO) is defined as a condition of normal body weight, but with high body fat percentage. Clinical and immunologic implications of NWO in persons living with HIV (PLHIV) remain unknown. The aim of this study was to examine NWO prevalence and its associations with metabolic and immunologic measurements in a cohort of PLHIV on antiretroviral treatment (ART).Methods: ...
DOI:
10.1016/j.nut.2021.111515

46. Pan‐cancer multi‐omics analyses reveal crosstalk between the Hippo and immune signaling pathways in the tumor microenvironment

Author:
Chengyu Wang; Tong Zhu; Zhangxiang Zhao; Bo Chen; Tingting Chen; Qi Dong; Mingyue Liu; Shuping Zhuang; Fan Yang; Yaoyao Liu; Min Yang; Yunyan Gu; Haihai Liang
Source:
FEBS letters 2022 v.596 no.4 pp. 449-464
ISSN:
0014-5793
Subject:
CD8-positive T-lymphocytes; carcinogenesis; carcinoma; endometrium; genes; multiomics; prognosis; transcription factors
Abstract:
... The Hippo signaling pathway is critical for carcinogenesis. However, the roles of the Hippo signaling pathway in the tumor immune microenvironment have been rarely investigated. This study systematically analyzed the relationship between the Hippo signaling pathway and immune cell infiltration across 32 cancer types. Both bioinformatics analyses and biological experiments revealed that the downstr ...
DOI:
10.1002/1873-3468.14249

47. Presentation of HIV and Mtb derived peptides by HLA-E

Author:
Lucy Walters; Karl Harlos; Daniel Rozbesky; Yvonne Jones; Andrew McMichael; Geraldine Gillespie
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; epitopes; exposure profile; humans; hydrophobicity; immunogenicity; mutagenesis; peptides; signal peptide; solvents; tuberculosis; vaccination; vaccine development
Abstract:
... Unconventional, Mamu-E-restricted CD8+ T cell responses directed against a diverse range of epitopes have been implicated as immune correlates of sterile immune protection in rhesus CMV-vectored SIV vaccination. In light of these findings, we have re-explored the peptide binding specificity of the human ortholog, HLA-E, from the view of developing a parallel HIV vaccination strategy in humans. Giv ...
DOI:
10.1016/j.molimm.2022.05.070

48. Pyrimethamine inhibits cell growth by inducing cell senescence and boosting CD8+ T-cell mediated cytotoxicity in colorectal cancer

Author:
Haiyan Dong; Limei Hu; Weiqian Li; Mengchen Shi; Lingyuan He; Chen Wang; Yijia Hu; Huihui Wang; Chuangyu Wen; Huanliang Liu; Xiangling Yang
Source:
Molecular biology reports 2022 v.49 no.6 pp. 4281-4292
ISSN:
0301-4851
Subject:
CD8-positive T-lymphocytes; animals; antineoplastic activity; cell growth; cell senescence; colorectal neoplasms; cytotoxicity; drug therapy; flow cytometry; interphase; molecular biology; pyrimethamine; sequence analysis
Abstract:
... BACKGROUND: The emergence of nonresponse or resistance to traditional chemotherapeutic agents is one of the main challenges of colorectal cancer (CRC) therapies. Thus, novel therapeutic drugs that can improve the clinical outcomes of CRC patients are urgently needed. The purpose of this study was to investigate the effects and mechanisms of pyrimethamine in CRC. METHODS AND RESULTS: In this study, ...
DOI:
10.1007/s11033-022-07262-y

49. Pyroptosis-inducing active caspase-1 as a genetic adjuvant in anti-cancer DNA vaccination

Author:
Tsolere Arakelian; Koen Oosterhuis; Elena Tondini; Mandy Los; Jana Vree; Mariska van Geldorp; Marcel Camps; Bram Teunisse; Iris Zoutendijk; Ramon Arens; Gerben Zondag; Ferry Ossendorp; Jeroen van Bergen
Source:
Vaccine 2022 v.40 no.13 pp. 2087-2098
ISSN:
0264-410X
Subject:
CD8-positive T-lymphocytes; adjuvants; caspase-1; epitopes; interleukin-1beta; melanoma; necroptosis; ovalbumin; plasmids; pyroptosis; recombinant vaccines; transfection; vaccination
Abstract:
... Pyroptosis is a recently discovered form of inflammatory programmed necrosis characterized by caspase-1-mediated and gasdermin D-dependent cell death leading to the release of pro-inflammatory cytokines such as Interleukin-1 beta (IL-1β). Here, we evaluated whether pyroptosis could be exploited in DNA vaccination by incorporating a constitutively active variant of caspase-1 to the antigen-expressi ...
DOI:
10.1016/j.vaccine.2022.02.028

50. SARS-CoV-2 Accessory Protein ORF8 Decreases Antibody-Dependent Cellular Cytotoxicity

Author:
Guillaume Beaudoin-Bussières; Ariana Arduini; Catherine Bourassa; Halima Medjahed; Gabrielle Gendron-Lepage; Jonathan Richard; Qinghua Pan; Zhen Wang; Chen Liang; Andrés Finzi
Source:
Viruses 2022 v.14 no.6 pp. -
ISSN:
1999-4915
Subject:
CD8-positive T-lymphocytes; Severe acute respiratory syndrome coronavirus 2; cytotoxicity; immune evasion; monocytes
Abstract:
... Viruses use many different strategies to evade host immune responses. In the case of SARS-CoV-2, its Spike mutates rapidly to escape from neutralizing antibodies. In addition to this strategy, ORF8, a small accessory protein encoded by SARS-CoV-2, helps immune evasion by reducing the susceptibility of SARS-CoV-2-infected cells to the cytotoxic CD8+ T cell response. Interestingly, among all accesso ...
DOI:
10.3390/v14061237

51. Scientific policy session: European GrantAntigen-delivery through invariant chain boosts CD8 and CD4 T cell immunity

Author:
Nadia Mensali; Amalie Grenov; Niladri Bhusan Pati; Else Marit Inderberg; Sébastien Wächli; Oddmund Bakke
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; antigens; cytotoxicity; immunologic memory; issues and policy; peptides; vaccination; vaccines
Abstract:
... Eradication of tumors by the immune system relies on the efficient activation of a T-cell response. For many years, the main focus of cancer immunotherapy has been on cytotoxic CD8 T-cell. However, stimulation of CD4 helper T cells is critical for the promotion and maintenance of immune memory, thus a good vaccine should evoke a two-dimensional T-cell response. The invariant chain (Ii) is required ...
DOI:
10.1016/j.molimm.2022.05.028

52. Serum Leptin Levels, Nutritional Status, and the Risk of Healthcare-Associated Infections in Hospitalized Older Adults

Author:
Elena Paillaud; Johanne Poisson; Clemence Granier; Antonin Ginguay; Anne Plonquet; Catherine Conti; Amaury Broussier; Agathe Raynaud-Simon; Sylvie Bastuji-Garin
Source:
Nutrients 2022 v.14 no.1 pp. -
ISSN:
2072-6643
Subject:
C-reactive protein; CD8-positive T-lymphocytes; albumins; blood serum; confidence interval; leptin; malnutrition; nutrition assessment; nutritional status; odds ratio; regression analysis; risk
Abstract:
... We aimed to determine whether serum leptin levels are predictive of the occurrence of healthcare-associated infections (HAIs) in hospitalized older patients. In a prospective cohort, 232 patients had available data for leptin and were monitored for HAIs for 3 months. Admission data included comorbidities, invasive procedures, the Mini Nutritional Assessment (MNA), BMI, leptin, albumin and C-reacti ...
DOI:
10.3390/nu14010226

53. Sialic acid blockade in dendritic cells enhances CD8+ T cell responses by facilitating high-avidity interactions

Author:
N. Balneger; L. A. M. Cornelissen; M. Wassink; S. J. Moons; T. J. Boltje; Y. E. Bar-Ephraim; K. K. Das; J. N. Søndergaard; C. Büll; G. J. Adema
Source:
Cellular and molecular life sciences 2022 v.79 no.2 pp. 98
ISSN:
1420-682X
Subject:
CD8-positive T-lymphocytes; Toll-like receptors; cell adhesion; cell proliferation; gene expression; gene expression regulation; glycolipids; glycoproteins; mice; polysaccharides; sialic acid; viability
Abstract:
... Sialic acids are negatively charged carbohydrates that cap the glycans of glycoproteins and glycolipids. Sialic acids are involved in various biological processes including cell–cell adhesion and immune recognition. In dendritic cells (DCs), the major antigen-presenting cells of the immune system, sialic acids emerge as important regulators of maturation and interaction with other lymphocytes incl ...
DOI:
10.1007/s00018-021-04027-x

54. Spotlight on TAP and its vital role in antigen presentation and cross-presentation

Author:
Ian Mantel; Barzan A. Sadiq; J. Magarian Blander
Source:
Molecular immunology 2022 v.142 pp. 105-119
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; antigen presentation; antigens; cytotoxicity; endoplasmic reticulum; endosomes; major histocompatibility complex; peptides; phagosomes; therapeutics
Abstract:
... In the late 1980s and early 1990s, the hunt for a transporter molecule ostensibly responsible for the translocation of peptides across the endoplasmic reticulum (ER) membrane yielded the successful discovery of transporter associated with antigen processing (TAP) protein. TAP is a heterodimer complex comprised of TAP1 and TAP2, which utilizes ATP to transport cytosolic peptides into the ER across ...
DOI:
10.1016/j.molimm.2021.12.013

55. TIL expansion with high dose IL-2 or low dose IL-2 with anti-CD3/anti-CD28 stimulation provides different quality of TIL-expanded T cell clones

Author:
Thidarat Kongkaew; Rattapoom Thaiwong; Suparat Tudsamran; Thitiya Sae-jung; Panjana Sengprasert; Apichai Vasuratna; Koramit Suppipat; Rangsima Reantragoon
Source:
Journal of immunological methods 2022 v.503 pp. 113229
ISSN:
0022-1759
Subject:
CD8-positive T-lymphocytes; immunotherapy; interleukin-2; ovarian neoplasms
Abstract:
... Tumor infiltrating lymphocytes (TILs) are cells that are present inside the tumor environment, of which include T cells, B cells and natural killer (NK) cells. At present, TILs are used for immunotherapy in various cancers. Knowledge on adoptive transfer of TILs in ovarian cancer is still limited, especially regarding TIL expansion methods. Therefore, the aim of our study was to compare the qualit ...
DOI:
10.1016/j.jim.2022.113229

56. Targeting APC-Host Microbe interactions 1Antigen presentation for liver-stage immunity to Plasmodium Infection

Author:
William Heath
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
Anopheles; CD8-positive T-lymphocytes; Plasmodium; antibodies; females; hepatocytes; immunity; liver; malaria; merozoites; sporozoites; vaccination; vaccines
Abstract:
... Malaria is a highly prevalent parasitic disease, accounting for approximately 216 million infections and 445,000 deaths per annum. Disease is caused by Plasmodium spp. and is transmitted via female Anopheles mosquitoes. Following a bite from an infected mosquito, immature parasites (sporozoites) are released into the skin and migrate via the blood to the liver where they asymptomatically infect he ...
DOI:
10.1016/j.molimm.2022.05.067

57. Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer

Author:
Rodrigo Nalio Ramos; Yoann Missolo-Koussou; Yohan Gerber-Ferder; Christian P. Bromley; Mattia Bugatti; Nicolas Gonzalo Núñez; Jimena Tosello Boari; Wilfrid Richer; Laurie Menger; Jordan Denizeau; Christine Sedlik; Pamela Caudana; Fiorella Kotsias; Leticia L. Niborski; Sophie Viel; Mylène Bohec; Sonia Lameiras; Sylvain Baulande; Laëtitia Lesage; André Nicolas; Didier Meseure; Anne Vincent-Salomon; Fabien Reyal; Charles-Antoine Dutertre; Florent Ginhoux; Lene Vimeux; Emmanuel Donnadieu; Bénédicte Buttard; Jérôme Galon; Santiago Zelenay; William Vermi; Pierre Guermonprez; Eliane Piaggio; Julie Helft
Source:
Cell 2022 v.185 no.7 pp. 1189-1207.e25
ISSN:
0092-8674
Subject:
CD8-positive T-lymphocytes; breast neoplasms; humans; immunity; macrophages; mammary glands; neoplasm progression; patients; therapeutics
Abstract:
... Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage might be endowed with distinct roles on cancer progression and antitumor immunity. Here, we identify a d ...
DOI:
10.1016/j.cell.2022.02.021

58. Tripartite-Motif 21 (TRIM21) Deficiency Results in a Modest Loss of Herpes Simplex Virus (HSV)-1 Surveillance in the Trigeminal Ganglia Following Cornea Infection

Author:
Amanda Berube; Grzegorz B. Gmyrek; Derek J. Royer; Daniel J. J. Carr
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
CD8-positive T-lymphocytes; angiogenesis; cornea; gene expression; herpes simplex; immunoglobulins; interferons; monitoring; opacity; viruses; vision
Abstract:
... Tripartite-motif 21 (TRIM21) is thought to regulate the type I interferon (IFN) response to virus pathogens and serve as a cytosolic Fc receptor for immunoglobulin. Since herpes simplex virus (HSV)-1 is sensitive to type I IFN and neutralizing antibody, we investigated the role of TRIM21 in response to ocular HSV-1 infection in mice. In comparison to wild type (WT) mice, TRIM21 deficient (TRIM21 K ...
DOI:
10.3390/v14030589

59. Using RiboSeq to Correlate the Cancer Translatome with the Immunopeptidome

Author:
Jaroslav Holly; Jiajie Wei; Mina Seedhom; Paul Schaughency; Justin Lack; Louis Staudt; Jonathan Yewdell
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
B-cell lymphoma; B-lymphocytes; CD8-positive T-lymphocytes; adults; cell differentiation; immunology; immunotherapy; mass spectrometry; peptides
Abstract:
... Diffuse large B cell lymphoma (DLBCL) is the most common adult non-Hodgkin lymphoma, and comprises a number of distinct B cell differentiation states. For a significant fraction of patients, current treatments are ineffective. To enable rational CD8+ T cell immunotherapy in DLBCLs and delineate the basic rules of peptide generation in cancer and normal cells we are defining the translatome in norm ...
DOI:
10.1016/j.molimm.2022.05.088

60. VSIG4/CRIg directly regulates early CD8+ T cell activation through its counter-receptor in a narrow window

Author:
Amrita Widyagarini; Naoto Nishii; Yohei Kawano; Chenyang Zhang; Miyuki Azuma
Source:
Biochemical and biophysical research communications 2022 v.614 pp. 100-106
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; homeostasis; ligands; phenotype; research
Abstract:
... T-cell responses are fine-tuned by positive and negative co-signal molecules expressed on immune cells and adjacent tissues. VSIG4 is a newly identified member of the B7 family of ligands, which negatively regulates innate inflammatory and CD4⁺ T cell-mediated responses. However, little is known about the direct effects of VSIG4, which are exerted through an unidentified counter-receptor on CD8⁺ T ...
DOI:
10.1016/j.bbrc.2022.04.120

61. Vaccine protection against the SARS-CoV-2 Omicron variant in macaques

Author:
Abishek Chandrashekar; Jingyou Yu; Katherine McMahan; Catherine Jacob-Dolan; Jinyan Liu; Xuan He; David Hope; Tochi Anioke; Julia Barrett; Benjamin Chung; Nicole P. Hachmann; Michelle Lifton; Jessica Miller; Olivia Powers; Michaela Sciacca; Daniel Sellers; Mazuba Siamatu; Nehalee Surve; Haley VanWyk; Huahua Wan; Cindy Wu; Laurent Pessaint; Daniel Valentin; Alex Van Ry; Jeanne Muench; Mona Boursiquot; Anthony Cook; Jason Velasco; Elyse Teow; Adrianus C.M. Boon; Mehul S. Suthar; Neharika Jain; Amanda J. Martinot; Mark G. Lewis; Hanne Andersen; Dan H. Barouch
Source:
Cell 2022 v.185 no.9 pp. 1549-1555.e11
ISSN:
0092-8674
Subject:
CD8-positive T-lymphocytes; Severe acute respiratory syndrome coronavirus 2; antibodies; nose; vaccines; viruses
Abstract:
... The rapid spread of the SARS-CoV-2 Omicron (B.1.1.529) variant, including in highly vaccinated populations, has raised important questions about the efficacy of current vaccines. In this study, we show that the mRNA-based BNT162b2 vaccine and the adenovirus-vector-based Ad26.COV2.S vaccine provide robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in cynomolgus macaq ...
DOI:
10.1016/j.cell.2022.03.024

62. Vitexin alleviates breast tumor in mice via skewing TAMs toward an iNOS+ profile orchestrating effective CD8+ T cell activation

Author:
Yonger Chen; Xin Yuan; Chaoying Pei; Zilu Deng; Xianhua Du; Jian Liang; Lian He; Shaozhen Hou
Source:
Journal of functional foods 2022 v.95 pp. 105190
ISSN:
1756-4646
Subject:
CD8-positive T-lymphocytes; allografting; antineoplastic activity; apigenin; breast neoplasms; females; glycosides; immune response; inducible nitric oxide synthase; interferon-gamma; lipopolysaccharides; macrophages; mice; phenotype; spleen
Abstract:
... Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment (TME) and often induce an immunosuppressed state. Vitexin is an apigenin flavone glycoside found in food and medicinal plants. Vitexin inhibits the growth of many tumors including breast cancer. However, the exact mechanism of the immune response of vitexin in breast cancer growth is not known. In ...
DOI:
10.1016/j.jff.2022.105190

63. What drives ‘Memory Inflation’ of CD8 T cells during Cytomegalovirus Latency?

Author:
Sabine Scheller; Marion Grießl; Angelique Renzaho; Matthias J Reddehase; Niels A Lemmermann
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; Cytomegalovirus; epitopes; genes; genomics; homeostasis; mice; monitoring; peptides; phenotype; transcription (genetics)
Abstract:
... Cytomegalovirus (CMV) infection is controlled by virus-specific CD8 T cells. After clearance of productive CMV infection viral latency will be established in multiple host tissues and CD8 T cells persist at extra-lymphoid sites. Although the overall absolute number of tissue-infiltrating CD8 T cells declines over time, CD8 T cells specific for certain viral epitopes accumulate over time also in ab ...
DOI:
10.1016/j.molimm.2022.05.040

64. The enhanced cell cycle related to the response to adjuvant therapy in pancreatic ductal adenocarcinoma

Author:
Yize Mao; Weisheng Cheng; Qiuxia Yang; Liqin Li; Wanming Hu; Zeyu Shuang; Dejun Fan; Xinlei Jiang; Feng Gao; Shengping Li; Wei Wang
Source:
Genomics 2022 v.114 no.1 pp. 95-106
ISSN:
0888-7543
Subject:
CD8-positive T-lymphocytes; adenocarcinoma; adjuvants; biomarkers; cell cycle; drug therapy; gene expression regulation; genomics; hypoxia; macrophages; patients; statistical analysis; suppressor genes
Abstract:
... A major clinical challenge for treating patients with pancreatic ductal adenocarcinoma (PDAC) is identifying those that may benefit from adjuvant chemotherapy versus those that will not. Thus, there is a need for a robust and convenient biomarker for predicting chemotherapy response in PDAC patients. In this study, network inference was conducted by integrating the differentially expressed cell cy ...
DOI:
10.1016/j.ygeno.2021.11.036

65. The function of IRAP+ endosomes in T cells

Author:
Irini Evnouchidou; Pascal Chappert; Samira Benadda; Andres Zucchetti; Mirjana Weimershaus; Marcelle Bens; Peter van Endert; Pierre Guermonprez; Claire Hivroz; David Gross; Loredana Saveanu
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; adaptive immunity; cell lines; endocytosis; endosomes; fluorescent antibody technique; genetically modified organisms; humans; immunization; immunological synapse; interleukin-2; mice; neoplasm cells; neoplasms; signal transduction; synapse
Abstract:
... T lymphocytes form an immunological synapse with cells infected by pathogens or cancer cells, after recognition of MHC-epitope complexes by the TCR. The expression of the TCR on the T cell surface, its internalization and its recycling are essential for the TCR signaling pathway. While the proteins implicated in this pathway are well known, there is controversy on the role of TCR endocytosis and r ...
DOI:
10.1016/j.molimm.2022.05.051

66. A novel epithelial-mesenchymal transition-related gene signature for prognosis prediction in patients with lung adenocarcinoma

Author:
Shengyu Feng; Ce Huang; Liuling Guo; Hao Wang; Hailiang Liu
Source:
Heliyon 2022 v.8 no.1 pp. e08713
ISSN:
2405-8440
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Singapore; adenocarcinoma; cell movement; data collection; genes; immunity; immunotherapy; lungs; microarray technology; models; neoplasm cells; prediction; prognosis; regression analysis; risk; sequence analysis
Abstract:
... Traditional pathological diagnoses and clinical methods are insufficient to accurately predict the prognosis of lung adenocarcinoma (LUAD). Epithelial-mesenchymal transition (EMT) process is closely related to tumor cell migration. However, the prognostic value of EMT-related genes in LUAD is still unclear. In this study, we collected bulk RNA-sequencing (RNA-seq) and microarray data of LUAD patie ...
DOI:
10.1016/j.heliyon.2022.e08713

67. A promiscuous T cell epitope-based HIV vaccine providing redundant population coverage of the HLA class II elicits broad, polyfunctional T cell responses in nonhuman primates

Author:
Susan Pereira Ribeiro; Vania Gomes De Moura Mattaraia; Rafael Ribeiro Almeida; Elizabeth Juliana Ghiuro Valentine; Natiely Silva Sales; Luís Carlos S. Ferreira; Luiz Carlos Sa-Rocha; Lucas Cauê Jacintho; Vinicius Canato Santana; John Sidney; Alessandro Sette; Daniela Santoro Rosa; Jorge Kalil; Edecio Cunha-Neto
Source:
Vaccine 2022 v.40 no.2 pp. 239-246
ISSN:
0264-410X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; COVID-19 infection; HIV infections; cell-mediated immunity; electroporation; epitopes; genetically modified organisms; human population; humans; immunization; peptides; recombinant vaccines
Abstract:
... Over the last few decades, several emerging or reemerging viral diseases with no readily available vaccines have ravaged the world. A platform to fastly generate vaccines inducing potent and durable neutralizing antibody and T cell responses is sorely needed. Bioinformatically identified epitope-based vaccines can focus on immunodominant T cell epitopes and induce more potent immune responses than ...
DOI:
10.1016/j.vaccine.2021.11.076

68. Antibody-mediated delivery of T-cell epitopes to antigen-presenting cells induce strong CD4 and CD8 T-cell responses

Author:
Lene S. Høydahl; Terje Frigstad; Ingunn B. Rasmussen; Inger Øynebråten; Karoline W. Schjetne; Jan Terje Andersen; Terje E. Michaelsen; Elin Lunde; Bjarne Bogen; Inger Sandlie
Source:
Vaccine 2021 v.39 no.11 pp. 1583-1592
ISSN:
0264-410X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; antibodies; antigen presentation; cytokines; epitopes; immunoglobulins; intravenous injection; secretion; vaccination; vaccines
Abstract:
... Targeted delivery of antigen to antigen-presenting cells (APCs) enhances antigen presentation and thus, is a potent strategy for making more efficacious vaccines. This can be achieved by use of antibodies with specificity for endocytic surface molecules expressed on the APC. We aimed to compare two different antibody-antigen fusion modes in their ability to induce T-cell responses; first, exchange ...
DOI:
10.1016/j.vaccine.2021.02.012

69. Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

Author:
Megan L. Burger; Amanda M. Cruz; Grace E. Crossland; Giorgio Gaglia; Cecily C. Ritch; Sarah E. Blatt; Arjun Bhutkar; David Canner; Tamina Kienka; Sara Z. Tavana; Alexia L. Barandiaran; Andrea Garmilla; Jason M. Schenkel; Michelle Hillman; Izumi de los Rios Kobara; Amy Li; Alex M. Jaeger; William L. Hwang; Peter M.K. Westcott; Michael P. Manos; Marta M. Holovatska; F. Stephen Hodi; Aviv Regev; Sandro Santagata; Tyler Jacks
Source:
Cell 2021 v.184 no.19 pp. 4996-5014.e26
ISSN:
0092-8674
Subject:
CD8-positive T-lymphocytes; adenocarcinoma; antigens; data collection; humans; lungs; mice; phenotype; vaccination
Abstract:
... CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is known about the interplay between responses and its impact on T cell function and tumor control. In mouse lung adenocarcinoma, we found that immunodominance is established in tumors, wherein CD8 T cell expansion is predominantly driven by the antigen that most stably binds MHC. T cells responding to subdom ...
DOI:
10.1016/j.cell.2021.08.020

70. Assessment of the population coverage of an HIV-1 vaccine targeting sequences surrounding the viral protease cleavage sites in Gag, Pol, or all 12 protease cleavage sites

Author:
Mathew Daniel; Binhua Liang; Ma Luo
Source:
Vaccine 2021 v.39 no.19 pp. 2676-2683
ISSN:
0264-410X
Subject:
CD8-positive T-lymphocytes; databases; epitopes; proteinases; vaccines; world wide web
Abstract:
... Development of an effective HIV-1 vaccine has been a great challenge faced by the research community. Recently a novel strategy targeting the viral protease cleavage sites (PCSs) has been tested and shown promising results. This T cell-based vaccine strategy depends on individuals expressing certain HLA class I molecules and since each population has unique distributions of HLA class I alleles, po ...
DOI:
10.1016/j.vaccine.2021.03.068

71. B-Cell Control of Regulatory T Cells in Friend Virus Infection

Author:
Tyler C. Moore; Kim J. Hasenkrug
Source:
Journal of molecular biology 2021 v.433 no.1 pp. 166583
ISSN:
0022-2836
Subject:
B-lymphocytes; CD8-positive T-lymphocytes; antibodies; antibody formation; antigen-presenting cells; models
Abstract:
... B lymphocytes have well-established effector roles during viral infections, including production of antibodies and functioning as antigen-presenting cells for CD4+ and CD8+ T cells. B cells have also been shown to regulate immune responses and induce regulatory T cells (Tregs). In the Friend virus (FV) model, Tregs are known to inhibit effector CD8+ T-cell responses and contribute to virus persist ...
DOI:
10.1016/j.jmb.2020.06.022

72. Broad-Based Influenza-Specific CD8+ T Cell Response without the Typical Immunodominance Hierarchy and Its Potential Implication

Author:
Miaojuan Huang; Rong Xu; Cristina Triffon; Nicole Mifsud; Weisan Chen
Source:
Viruses 2021 v.13 no.6 pp. -
ISSN:
1999-4915
Subject:
CD8-positive T-lymphocytes; Influenza A virus; amino acids; epitopes; mice; models; prediction; Australia
Abstract:
... Syngeneic murine systems have pre-fixed MHC, making them an imperfect model for investigating the impact of MHC polymorphism on immunodominance in influenza A virus (IAV) infections. To date, there are few studies focusing on MHC allelic differences and its impact on immunodominance even though it is well documented that an individual’s HLA plays a significant role in determining immunodominance h ...
DOI:
10.3390/v13061080

73. CD4 T Cell-Mediated Immune Control of Cytomegalovirus Infection in Murine Salivary Glands

Author:
Nathan Zangger; Josua Oderbolz; Annette Oxenius
Source:
Pathogens 2021 v.10 no.12 pp. -
ISSN:
2076-0817
Subject:
B-lymphocytes; CD8-positive T-lymphocytes; Cytomegalovirus infections; Muromegalovirus; interferon-gamma; mechanism of action; mice; tumor necrosis factor-alpha
Abstract:
... CD4 T cells are well known for their supportive role in CD8 T cell and B cell responses during viral infection. However, during murine cytomegalovirus (MCMV) infection in the salivary glands (SGs), CD4 T cells exhibit direct antiviral effector functions to control the infection. In this mucosal organ, opposed to other infected tissues, MCMV establishes a sustained lytic replication that lasts for ...
DOI:
10.3390/pathogens10121531

74. CD4+ and CD8+ Circulating Memory T Cells Are Crucial in the Protection Induced by Vaccination with Salmonella Typhi Porins

Author:
Luis Ontiveros-Padilla; Alberto García-Lozano; Araceli Tepale-Segura; Tania Rivera-Hernández; Rodolfo Pastelin-Palacios; Armando Isibasi; Lourdes A. Arriaga-Pizano; Laura C. Bonifaz; Constantino López-Macías
Source:
Microorganisms 2021 v.9 no.4 pp. -
ISSN:
2076-2607
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Salmonella Typhi; immune response; lymph nodes; memory; microbial load; phenotype; porins; vaccination
Abstract:
... Salmonella enterica serovar Typhi (S. Typhi) porins, OmpC and OmpF, are potent inducers of the immune response against S. Typhi in mice and humans. Vaccination with porins induces the protection against 500 LD₅₀ of S. Typhi, life-lasting bactericidal antibodies and effector T cell responses in mice; however, the nature of the memory T cell compartment and its contribution to protection remains unk ...
DOI:
10.3390/microorganisms9040770

75. Cellular Immune Response Induced by DNA Immunization of Mice with Drug Resistant Integrases of HIV-1 Clade A Offers Partial Protection against Growth and Metastatic Activity of Integrase-Expressing Adenocarcinoma Cells

Author:
Maria Isaguliants; Olga Krotova; Stefan Petkov; Juris Jansons; Ekaterina Bayurova; Dzeina Mezale; Ilze Fridrihsone; Athina Kilpelainen; Philip Podschwadt; Yulia Agapkina; Olga Smirnova; Linda Kostic; Mina Saleem; Oleg Latyshev; Olesja Eliseeva; Anastasia Malkova; Tatiana Gorodnicheva; Britta Wahren; Ilya Gordeychuk; Elizaveta Starodubova; Anastasia Latanova
Source:
Microorganisms 2021 v.9 no.6 pp. -
ISSN:
2076-2607
Subject:
CD8-positive T-lymphocytes; DNA; adenocarcinoma; antigens; antiretroviral agents; carcinogenicity; cell-mediated immunity; drug resistance; immunization; immunogenicity; immunotoxicity; integrases; metastasis; oxidative stress; proteolysis
Abstract:
... Therapeutic DNA-vaccination against drug-resistant HIV-1 may hinder emergence and spread of drug-resistant HIV-1, allowing for longer successful antiretroviral treatment (ART) up-to relief of ART. We designed DNA-vaccines against drug-resistant HIV-1 based on consensus clade A integrase (IN) resistant to raltegravir: IN_in_r1 (L74M/E92Q/V151I/N155H/G163R) or IN_in_r2 (E138K/G140S/Q148K) carrying D ...
DOI:
10.3390/microorganisms9061219

76. Characterization of Immune Cell Subsets of Tumor Infiltrating Lymphocytes in Brain Metastases

Author:
Priyakshi Kalita-de Croft; Haarika Chittoory; Tam H. Nguyen; Jodi M. Saunus; Woo Gyeong Kim; Amy E. McCart Reed; Malcolm Lim; Xavier M. De Luca; Kaltin Ferguson; Colleen Niland; Roberta Mazzieri; Riccardo Dolcetti; Peter T. Simpson; Sunil R. Lakhani
Source:
Biology 2021 v.10 no.5 pp. -
ISSN:
2079-7737
Subject:
CD8-positive T-lymphocytes; RNA; brain; fluorescent antibody technique; immunosuppression; metastasis; monitoring; neoplasms; neuroglia; phenotype
Abstract:
... The heterogeneity of tumor infiltrating lymphocytes (TILs) is not well characterized in brain metastasis. To address this, we performed a targeted analysis of immune-cell subsets in brain metastasis tissues to test immunosuppressive routes involved in brain metastasis. We performed multiplex immunofluorescence (mIF), using commercially available validated antibodies on formalin-fixed paraffin embe ...
DOI:
10.3390/biology10050425

77. Comparative analysis of key immune protection factors in H9N2 avian influenza viruses infected and immunized specific pathogen–free chicken

Author:
Manman Dai; Shibing Li; Keyi Shi; Hui Sun; Li Zhao; Deshui Yu; Jiayu Liao; Chenggang Xu; Ming Liao
Source:
Poultry science 2021 v.100 no.1 pp. 39-46
ISSN:
0032-5791
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Influenza A virus; antibodies; chickens; cytokines; flocks; gene expression; genes; immune response; immunization; inactivated vaccines; lungs; China
Abstract:
... H9N2 avian influenza viruses (AIV) continue to circulate in vaccinated chicken flocks in China, which prompted us to investigate the differential immune protection factors induced by H9N2 AIV infection and immunization for analyzing the reason of protection deficiency of H9N2 AIV inactivated vaccine. In this study, we firstly explored virus-induced optimal immune responses in chicken after H9N2 AI ...
DOI:
10.1016/j.psj.2020.09.080

78. Creatine in T Cell Antitumor Immunity and Cancer Immunotherapy

Author:
Bo Li; Lili Yang
Source:
Nutrients 2021 v.13 no.5 pp. -
ISSN:
2072-6643
Subject:
CD8-positive T-lymphocytes; bioenergy; creatine; dietary supplements; immunity; immunotherapy; mice; muscles; neoplasms
Abstract:
... Creatine is a broadly used dietary supplement that has been extensively studied for its benefit on the musculoskeletal system. Yet, there is limited knowledge regarding the metabolic regulation of creatine in cells beyond the muscle. New insights concerning various regulatory functions for creatine in other physiological systems are developing. Here, we highlight the latest advances in understandi ...
DOI:
10.3390/nu13051633

79. Development of a long-term, IL7 dependent cell death rescue assay in CD4+ T-cells

Author:
Daniel Perez-Witzke; Rekha Parmar; Ileana Blancq; Marie-Alix Turpin; Frederique Ponchel
Source:
Journal of immunological methods 2021 v.493 pp. 113020
ISSN:
0022-1759
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; agonists; antagonism; antibodies; cell cycle; cell death; cell proliferation; cell viability; drugs; dyes; interleukin-7; long term effects; mitogens; phytohemagglutinin; therapeutics
Abstract:
... Interfering with signalling pathways by targeting cell surface proteins has become an important strategy in the development of novel therapeutic agents. Notably, interfering with cytokine signalling revolutionised the treatment of chronic diseases. Cytokines can induce a range of effects that are not always accounted for in assays detecting cytokine binding to cell surface receptors and/or proxima ...
DOI:
10.1016/j.jim.2021.113020

80. Development of a novel ZIKV vaccine comprised of immunodominant CD4+ and CD8+ T cell epitopes identified through comprehensive epitope mapping in Zika virus infected mice

Author:
Jin Sun; Zhihang Zheng; Min Li; Zhihua Liu; Xiao Su; Xia Jin
Source:
Vaccine 2021 v.39 no.36 pp. 5173-5186
ISSN:
0264-410X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Zika virus; antibodies; cytokines; cytotoxicity; humans; immunization; immunodominant epitopes; polyproteins; vaccines; viruses
Abstract:
... Zika virus (ZIKV) caused over two million human infections in more than 80 countries around 2015–2016. Current vaccines under development are mostly focused on inducing antibodies that despite capable of inhibiting the virus, may have the potential to trigger antibody dependent enhancement (ADE). T cell vaccines that do not induce antibodies targeting viral surface will unlikely cause ADE, but be ...
DOI:
10.1016/j.vaccine.2021.07.036

81. Development of thermosensitive resiquimod-loaded liposomes for enhanced cancer immunotherapy

Author:
Hua Zhang; Wei-Lun Tang; Azadeh Kheirolomoom; Brett Z. Fite; Bo Wu; Kenneth Lau; Mo Baikoghli; Marina Nura Raie; Spencer K. Tumbale; Josquin Foiret; Elizabeth S. Ingham; Lisa M. Mahakian; Sarah M. Tam; R. Holland Cheng; Alexander D. Borowsky; Katherine W. Ferrara
Source:
Journal of controlled release 2021 v.330 pp. 1080-1094
ISSN:
0168-3659
Subject:
CD8-positive T-lymphocytes; Toll-like receptor 7; agonists; animal models; breast neoplasms; ferrous sulfate; fever; hypertrophy; immunohistochemistry; immunostimulants; immunotherapy; intravenous injection; lipids; mammary neoplasms (animal); mice; neoplasm cells; remission; solubility; thermosensitivity; weight loss
Abstract:
... Resiquimod (R848) is a toll-like receptor 7 and 8 (TLR7/8) agonist with potent antitumor and immunostimulatory activity. However, systemic delivery of R848 is poorly tolerated because of its poor solubility in water and systemic immune activation. In order to address these limitations, we developed an intravenously-injectable formulation with R848 using thermosensitive liposomes (TSLs) as a delive ...
DOI:
10.1016/j.jconrel.2020.11.013

82. Dual role of immunomodulation by crude polysaccharide from okra against carcinogenic liver injury in mice

Author:
Suhailah Hayaza; Sri Puji Astuti Wahyuningsih; Raden Joko Kuncoroningrat Susilo; Saikhu Akhmad Husen; Dwi Winarni; Ruey-an Doong; Win Darmanto
Source:
Heliyon 2021 v.7 no.2 pp. e06183
ISSN:
2405-8440
Subject:
Abelmoschus esculentus; CD8-positive T-lymphocytes; body weight; carcinogenicity; diethylnitrosamine; doxorubicin; immunomodulation; interleukin-2; liver; macrophages; males; okra; polysaccharides; Indonesia
Abstract:
... Polysaccharides have long been recognized as the anticancer agent with low toxicity and slight side effects. Okra (Abelmoschus esculentus L.), a flowering plant from the Malvaceae family that is found in tropical, subtropical, and warm temperate regions around the world. Hence, no in vivo studies have addressed the anticancer and immunomodulatory potential of polysaccharides from okra pods grown i ...
DOI:
10.1016/j.heliyon.2021.e06183

83. ELISA based on peptide antigens reproducing cross-reactive viral epitopes to detect antibodies in latent autoimmune diabetes in adults vs. type 1 diabetes

Author:
Feliciana Real-Fernández; Alessandra Gallo; Francesca Nuti; Lorenzo Altamore; Gloria Giovanna Del Vescovo; Pietro Traldi; Eugenio Ragazzi; Paolo Rovero; Annunziata Lapolla; Anna Maria Papini
Source:
MethodsX 2021 v.8 pp. 101452
ISSN:
2215-0161
Subject:
CD8-positive T-lymphocytes; autoantibodies; autoimmunity; biomarkers; diagnostic techniques; disease diagnosis; epitopes; insulin-dependent diabetes mellitus; patients; synthetic peptides
Abstract:
... Diagnosis of Latent Autoimmune Diabetes in Adults (LADA) is based on the adult-age, anti-islet autoantibodies, and temporary insulin-independence. As in Type-1-Diabetes (T1DM), autoimmunity may trigger LADA and enteroviruses-infections can play a role. Anti-human Glutamic-Acid-Decarboxylase (hGAD) autoantibodies are accepted clinical biomarkers, but do not discriminate LADA vs. T1DM. The hypothesi ...
DOI:
10.1016/j.mex.2021.101452

84. Efficient Control of Zika Virus Infection Induced by a Non-Replicating Adenovector Encoding Zika Virus NS1/NS2 Antigens Fused to the MHC Class II-Associated Invariant Chain

Author:
Loulieta Nazerai; Søren Buus; Anette Stryhn; Allan Randrup Thomsen; Jan Pravsgaard Christensen
Source:
Viruses 2021 v.13 no.11 pp. -
ISSN:
1999-4915
Subject:
Adenoviridae; CD8-positive T-lymphocytes; Zika virus; immunogenicity; vaccination; vaccines
Abstract:
... It is generally believed that a successful Zika virus (ZIKV) vaccine should induce neutralizing antibodies against the ZIKV envelope (E) protein to efficiently halt viral infection. However, E-specific neutralizing antibodies have been implicated in a phenomenon called antibody-dependent enhancement, which represents an ongoing concern in the flavivirus-vaccinology field. In this report, we invest ...
DOI:
10.3390/v13112215

85. Employing hypoxia characterization to predict tumour immune microenvironment, treatment sensitivity and prognosis in hepatocellular carcinoma

Author:
Fanhong Zeng; Yue Zhang; Xu Han; Min Zeng; Yi Gao; Jun Weng
Source:
Computational and Structural Biotechnology Journal 2021 v.19 pp. 2775-2789
ISSN:
2001-0370
Subject:
CD8-positive T-lymphocytes; biotechnology; carcinogenesis; cytokines; hepatoma; hypoxia; immunosuppression; immunotherapy; landscapes; metabolism; models; neoplasm progression; patients; phenotype; prognosis; resection; risk; transcriptome
Abstract:
... The hypoxic microenvironment was recognized as a major driving force of the malignant phenotype in hepatocellular carcinoma (HCC), which contributes to tumour immune microenvironment (TIM) remodeling and tumor progression. Dysregulated hypoxia-related genes (HRGs) result in treatment resistance and poor prognosis by reshaping tumor cellular activities and metabolism. Approaches to identify the rel ...
DOI:
10.1016/j.csbj.2021.03.033

86. Evaluation of protection induced by in vitro maturated BMDCs presenting CD8+ T cell stimulating peptides after a heterologous vaccination regimen in BALB/c model against Leishmania major

Author:
Atefeh Sadeghi Shermeh; Farnaz Zahedifard; Sima Habibzadeh; Tahereh Taheri; Sima Rafati; Negar Seyed
Source:
Experimental parasitology 2021 v.223 pp. 108082
ISSN:
0014-4894
Subject:
CD8-positive T-lymphocytes; DNA; Leishmania major; cutaneous leishmaniasis; dendritic cells; epitopes; mice; models; oligodeoxyribonucleotides; parasites; parasitology; peptides; proteome; recombinant vaccines; vaccination; vector-borne diseases
Abstract:
... Leishmaniasis is a complex vector-borne disease mediated by Leishmania parasite and a strong and long-lasting CD4⁺ Th1 and CD8⁺-T cell immunity is required to control the infection. Thus far multivalent subunit vaccines have met this requirement more promisingly. However several full protein sequences cannot be easily arranged in one construct. Instead, new emerging immune-informatics based epitop ...
DOI:
10.1016/j.exppara.2021.108082

87. Experimental study of Forsythoside A on prevention and treatment of avian infectious bronchitis

Author:
Xuebing Wang; Xiao Li; Xuefang Wang; Ling Chen; Erjuan Ning; Yi Fan; Hao Wang; Tong Chen; Wei Wang
Source:
Research in veterinary science 2021 v.135 pp. 523-531
ISSN:
0034-5288
Subject:
CD8-positive T-lymphocytes; Forsythia suspensa; Infectious bronchitis virus; Oriental traditional medicine; active ingredients; histopathology; immunomodulation; infectious bronchitis; interleukin-2; research; therapeutics; veterinary medicine
Abstract:
... Forsythoside A is the main active ingredient in the Chinese medicine Forsythia suspensa, which has antiviral, anti-inflammatory, antioxidation, and immunoregulatory effects. It is reported that Forsythoside A can significantly inhibit the replication of the avian infectious bronchitis virus(IBV) in cells, but there is no report in chickens. The present study aimed to investigate the effect of Fors ...
DOI:
10.1016/j.rvsc.2020.11.009

88. Flt3-L enhances trans-epithelial migration and antigen presentation of dendritic cells adoptively transferred to genital mucosa

Author:
Jaehyung Park; Hannah Frizzell; Hangyu Zhang; Shijie Cao; Sean M. Hughes; Florian Hladik; David M. Koelle; Kim A. Woodrow
Source:
Journal of controlled release 2021 v.329 pp. 782-793
ISSN:
0168-3659
Subject:
CD8-positive T-lymphocytes; antigen presentation; chitosan; dendritic cells; enzymes; female genitalia; female reproductive system; intravenous injection; ligands; lymph nodes; mice; mucosa; tyrosine; vaccination
Abstract:
... Dendritic cells (DCs) play a critical role in shaping adaptive immunity. Systemic transfer of DCs by intravenous injection has been widely investigated to inform the development of immunogenic DCs for use as cellular therapies. Adoptive transfer of DCs to mucosal sites has been limited but serves as a valuable tool to understand the role of the microenvironment on mucosal DC activation, maturation ...
DOI:
10.1016/j.jconrel.2020.10.012

89. Germinated black soybean fermented with Lactobacillus pentosus SC65 alleviates DNFB-induced delayed-type hypersensitivity in C57BL/6N mice

Author:
Hye-Ji Lee; Ha-Eun Cho; Hye-Jin Park
Source:
Journal of ethnopharmacology 2021 v.265 pp. 113236
ISSN:
0378-8741
Subject:
2,2-diphenyl-1-picrylhydrazyl; CD8-positive T-lymphocytes; Lactobacillus pentosus; Oriental traditional medicine; Pediococcus pentosaceus; Rhynchosia; anti-inflammatory activity; antioxidant activity; chemokine CCL5; daidzein; delayed hypersensitivity; dexamethasone; diabetes; ears; ethanol; foods; genistein; glycitein; hyperplasia; hypertension; immunity; immunohistochemistry; inflammation; interleukin-10; interleukin-1beta; interleukin-6; lactic acid bacteria; lipopolysaccharides; macrophages; messenger RNA; mice; natural killer cells; osteoporosis; permeability; polyphenols; reverse transcriptase polymerase chain reaction; soybeans; tumor necrosis factors; East Asia
Abstract:
... Rhynchosia nulubilis (black soybean) has many applications in oriental medicine. It is traditionally used to treat disease related with high blood pressure, diabetes, inflammation, and osteoporosis. Furthermore, fermented soybean foods have traditionally been used for immunity enhancement in East Asia. However, the anti-inflammatory effects of germinated R. nulubilis (GR) against delayed-type hype ...
DOI:
10.1016/j.jep.2020.113236

90. Goose Nephritic Astrovirus Infection of Goslings Induces Lymphocyte Apoptosis, Reticular Fiber Destruction, and CD8 T-Cell Depletion in Spleen Tissue

Author:
Rui Ding; Han Huang; Hongyu Wang; Zewen Yi; Siyu Qiu; Yingjun Lv; Endong Bao
Source:
Viruses 2021 v.13 no.6 pp. -
ISSN:
1999-4915
Subject:
CD8-positive T-lymphocytes; apoptosis; chromatin; gout; industry; macrophages; mitochondria; mortality; necrosis; plasma membrane; protein synthesis; pulp; spleen; viral load
Abstract:
... The emergence of a novel goose nephritic astrovirus (GNAstV) has caused economic losses to the Chinese goose industry. High viral load is found in the spleen of goslings infected with GNAstV, but pathological injuries to the spleen due to GNAstV are largely unknown. In this study, 50 two-day-old goslings were infected orally with GNAstV, and 50 goslings were treated with PBS as control. Spleens we ...
DOI:
10.3390/v13061108

91. High CD169 Monocyte/Lymphocyte Ratio Reflects Immunophenotype Disruption and Oxygen Need in COVID-19 Patients

Author:
Antonella Minutolo; Vita Petrone; Marialaura Fanelli; Marco Iannetta; Martina Giudice; Ines Ait Belkacem; Marta Zordan; Pietro Vitale; Guido Rasi; Paola Sinibaldi-Vallebona; Loredana Sarmati; Massimo Andreoni; Fabrice Malergue; Emanuela Balestrieri; Sandro Grelli; Claudia Matteucci
Source:
Pathogens 2021 v.10 no.12 pp. -
ISSN:
2076-0817
Subject:
B-lymphocytes; CD8-positive T-lymphocytes; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; biomarkers; disease progression; dose response; flow cytometry; fluorescence; immunophenotype; immunophenotyping; interleukin-10; interleukin-6; lectins; monocytes; oxygen; pneumonia; transcription (genetics)
Abstract:
... Background: Sialoadhesin (CD169) has been found to be overexpressed in the blood of COVID-19 patients and identified as a biomarker in early disease. We analyzed CD169 in the blood cells of COVID-19 patients to assess its role as a predictive marker of disease progression and clinical outcomes. Methods: The ratio of the median fluorescence intensity of CD169 between monocytes and lymphocytes (CD16 ...
DOI:
10.3390/pathogens10121639

92. Identification of Novel Candidate CD8+ T Cell Epitopes of the SARS-CoV2 with Homology to Other Seasonal Coronaviruses

Author:
Pradeep Darshana Pushpakumara; Deshan Madhusanka; Saubhagya Dhanasekara; Chandima Jeewandara; Graham S. Ogg; Gathsaurie Neelika Malavige
Source:
Viruses 2021 v.13 no.6 pp. -
ISSN:
1999-4915
Subject:
CD8-positive T-lymphocytes; Orthocoronavirinae; databases; epitopes; immunity; immunopathology; nucleocapsid; pathogenesis; phenotype; viruses
Abstract:
... Cross-reactive T cell immunity to seasonal coronaviruses (HCoVs) may lead to immunopathology or protection during SARS-CoV2 infection. To understand the influence of cross-reactive T cell responses, we used IEDB (Immune epitope database) and NetMHCpan (ver. 4.1) to identify candidate CD8⁺ T cell epitopes, restricted through HLA-A and B alleles. Conservation analysis was carried out for these epito ...
DOI:
10.3390/v13060972

93. Immunoinformatics approach for multi-epitope vaccine design against P. falciparum malaria

Author:
Leah Maharaj; Victoria T. Adeleke; Abiodun J. Fatoba; Adebayo A. Adeniyi; Selaelo I. Tshilwane; Matthew A. Adeleke; Rajendra Maharaj; Moses Okpeku
Source:
Infection, genetics, and evolution 2021 v.92 pp. 104875
ISSN:
1567-1348
Subject:
B-lymphocytes; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; HLA antigens; Plasmodium falciparum; adjuvants; computer simulation; epitopes; etiological agents; evolution; falciparum malaria; genetics; immune response; immunogenicity; immunoinformatics; infection; infectious diseases; molecular dynamics; prediction; vaccine development; vaccines
Abstract:
... Plasmodium falciparum (P. falciparum) is a leading causative agent of malaria, an infectious disease that can be fatal. Unfortunately, control measures are becoming less effective over time. A vaccine is needed to effectively control malaria and lead towards the total elimination of the disease. There have been multiple attempts to develop a vaccine, but to date, none have been certified as approp ...
DOI:
10.1016/j.meegid.2021.104875

94. Immunoinformatics prediction of overlapping CD8+ T-cell, IFN-γ and IL-4 inducer CD4+ T-cell and linear B-cell epitopes based vaccines against COVID-19 (SARS-CoV-2)

Author:
Abiodun J. Fatoba; Leah Maharaj; Victoria T. Adeleke; Moses Okpeku; Adebayo A Adeniyi; Matthew A. Adeleke
Source:
Vaccine 2021 v.39 no.7 pp. 1111-1121
ISSN:
0264-410X
Subject:
B-lymphocytes; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; COVID-19 infection; HLA antigens; Severe acute respiratory syndrome coronavirus 2; Toll-like receptor 3; databases; epitopes; experimental design; glycoproteins; immunogenicity; immunoinformatics; interleukin-4; live vaccines; major histocompatibility complex; pandemic; prediction; structural proteins; vaccine development; viruses
Abstract:
... At the beginning of the year 2020, the world was struck with a global pandemic virus referred to as SARS-CoV-2 (COVID-19) which has left hundreds of thousands of people dead. To control this virus, vaccine design becomes imperative. In this study, potential epitopes-based vaccine candidates were explored. Six hundred (600) genomes of SARS-CoV-2 were retrieved from the viPR database to generate CD8 ...
DOI:
10.1016/j.vaccine.2021.01.003

95. Impairment of CD4+ T and Memory B Cell Responses but Normal Memory CD8+T-Cell Activation on Crohn’s Disease after COVID-19 Vaccination: A Twin Case

Author:
Fabiana Gil Melgaço; Tamiris Azamor; Livia Melo Villar; Ana Paula Dinis Ano Bom; Juliana Gil Melgaço
Source:
Viruses 2021 v.13 no.11 pp. -
ISSN:
1999-4915
Subject:
B-lymphocytes; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; antibody detection; antibody formation; autoimmune diseases; memory; patients; vaccination
Abstract:
... Vaccines to prevent the impact of SARS-CoV-2 are now available, including for patients with autoimmune diseases. However, there is no information about how inflammatory bowel disease (IBD) treatment could impact the cellular and humoral immune responses. This study evaluated SARS-CoV-2-specific humoral and cellular responses after vaccination with a two-dose schedule in a Crohn’s disease patient t ...
DOI:
10.3390/v13112143

96. Implementation of in silico methods to predict common epitopes for vaccine development against Chikungunya and Mayaro viruses

Author:
Hammadul Hoque; Rahatul Islam; Srijon Ghosh; Md. Mashiur Rahaman; Nurnabi Azad Jewel; Md. Abunasar Miah
Source:
Heliyon 2021 v.7 no.3 pp. e06396
ISSN:
2405-8440
Subject:
B-lymphocytes; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Chikungunya virus; Mayaro virus; Neotropics; computer simulation; epitopes; immunoinformatics; peptides; polyproteins; vaccine development; vaccines
Abstract:
... Being a Positive sense RNA virus the recent reemergence of Chikungunya and Mayaro virus has taken the concern of the leading scientific communities of the world. Though the outbreak of Mayaro virus is limited to Neotropical region only, Chikungunya is already identified in over 60 countries around the world. Besides, the lack of a strong protective treatment, misdiagnosis issue and co-circulation ...
DOI:
10.1016/j.heliyon.2021.e06396

97. Injectable shear-thinning polylysine hydrogels for localized immunotherapy of gastric cancer through repolarization of tumor-associated macrophages

Author:
Yan Yang; Yang Yang; Meili Chen; Jianquan Chen; Jinyan Wang; Yajun Ma; Hanqing Qian
Source:
Biomaterials science 2021 v.9 no.19 pp. 6597-6608
ISSN:
2047-4849
Subject:
CD8-positive T-lymphocytes; biocompatible materials; hydrogels; immunosuppression; immunotherapy; interleukin-6; macrophages; models; phenotype; polyethylene glycol; schiff bases; stomach neoplasms; xenotransplantation
Abstract:
... Immunotherapy has emerged as one of the most promising treatments for cancer in recent years. However, it works only for a small proportion of patients, which can in part be attributed to the immunosuppressive tumor microenvironment (TME). Tumor associated macrophages (TAMs) are the critical components of tumors and play an important role in the development of the immunosuppressive TME. The transi ...
DOI:
10.1039/d1bm01053k

98. Intrauterine Fetal Demise After Uncomplicated COVID-19: What Can We Learn from the Case?

Author:
Pavel Babal; Lucia Krivosikova; Lucia Sarvaicova; Ivan Deckov; Tomas Szemes; Tatiana Sedlackova; Michal Palkovic; Anna Kalinakova; Pavol Janega
Source:
Viruses 2021 v.13 no.12 pp. -
ISSN:
1999-4915
Subject:
B-lymphocytes; CD8-positive T-lymphocytes; COVID-19 infection; RNA; Severe acute respiratory syndrome coronavirus 2; case studies; death; disease course; fetus; hybridization; immunohistochemistry; ischemia; lungs; maternal immunity; necropsy; neutrophils; nucleocapsid; patients; pregnancy; transplacental transmission; trophoblast; viruses
Abstract:
... Background: SARS-CoV-2 infection in pregnant women can lead to placental damage and transplacental infection transfer, and intrauterine fetal demise is an unpredictable event. Case study: A 32-year-old patient in her 38th week of pregnancy reported loss of fetal movements. She overcame mild COVID-19 with positive PCR test 22 days before. A histology of the placenta showed deposition of intervillou ...
DOI:
10.3390/v13122545

99. In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer

Author:
Zeyu Chen; Eri Arai; Omar Khan; Zhen Zhang; Shin Foong Ngiow; Yuan He; Hua Huang; Sasikanth Manne; Zhendong Cao; Amy E. Baxter; Zhangying Cai; Elizabeth Freilich; Mohammed A. Ali; Josephine R. Giles; Jennifer E. Wu; Allison R. Greenplate; Mohamed A. Hakeem; Qingzhou Chen; Makoto Kurachi; Kito Nzingha; Viktoriya Ekshyyan; Divij Mathew; Zhuoyu Wen; Nancy A. Speck; Alexis Battle; Shelley L. Berger; E. John Wherry; Junwei Shi
Source:
Cell 2021 v.184 no.5 pp. 1262-1280.e22
ISSN:
0092-8674
Subject:
CD8-positive T-lymphocytes; Eragrostis tef; cell differentiation; chromatin; immunity; immunotherapy; memory; transcription (genetics)
Abstract:
... Improving effector activity of antigen-specific T cells is a major goal in cancer immunotherapy. Despite the identification of several effector T cell (TEFF)-driving transcription factors (TFs), the transcriptional coordination of TEFF biology remains poorly understood. We developed an in vivo T cell CRISPR screening platform and identified a key mechanism restraining TEFF biology through the ETS ...
DOI:
10.1016/j.cell.2021.02.019

100. In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions

Author:
Hongling Huang; Peipei Zhou; Jun Wei; Lingyun Long; Hao Shi; Yogesh Dhungana; Nicole M. Chapman; Guotong Fu; Jordy Saravia; Jana L. Raynor; Shaofeng Liu; Gustavo Palacios; Yong-Dong Wang; Chenxi Qian; Jiyang Yu; Hongbo Chi
Source:
Cell 2021 v.184 no.5 pp. 1245-1261.e21
ISSN:
0092-8674
Subject:
CD8-positive T-lymphocytes; Eragrostis tef; amino acids; cell cycle; nutrient uptake
Abstract:
... How early events in effector T cell (TEFF) subsets tune memory T cell (TMEM) responses remains incompletely understood. Here, we systematically investigated metabolic factors in fate determination of TEFF and TMEM cells using in vivo pooled CRISPR screening, focusing on negative regulators of TMEM responses. We found that amino acid transporters Slc7a1 and Slc38a2 dampened the magnitude of TMEM di ...
DOI:
10.1016/j.cell.2021.02.021