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1. IL- 10 Augments Antibody Production in in Vitro Immunized Lymphocytes by Inducing a Th2-Type Response and B Cell Maturation

Author:
Qianghua XU; Yoshinori KATAKURA; Makiko YAMASHITA; Shengguo FANG; Takashi TAMURA; Shin-ei MATSUMOTO; Yoshihiro AIBA; Kiichiro TERUYA; Kazuhiro OSADA; Ryuhei NISHIKAWA; Sanetaka SHIRAHATA
Source:
Bioscience, biotechnology, and biochemistry 2004 v.68 no.11 pp. 2279-2284
ISSN:
1347-6947
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; antibody formation; antigens; cell differentiation; cell-mediated immunity; dipeptides; humans; immunization; interleukin-10; interleukin-2; interleukin-4; plasma cells
Abstract:
... An in vitro immunization (IVI) protocol enables antigen specific antibody production from L-Leucyl-L-Leucine methyl ester (LLME)-treated human peripheral blood lymphocytes (PBL) upon antigen stimulation in the presence of IL-2, IL-4, and muramyl dipeptide. In the course of our studies, we have found that IL-10 added at the antigen sensitization significantly augmented antibody production level fro ...
DOI:
10.1271/bbb.68.2279

2. IL- 10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection

Author:
Brooks, David G.; Walsh, Kevin B.; Elsaesser, Heidi; Oldstone, Michael B.A.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.7 pp. 3018-3023
ISSN:
0027-8424
Subject:
memory; adjuvants; vaccination; Lymphocytic choriomeningitis mammarenavirus; interleukin-10; immune response; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes
Abstract:
... Mounting effective T cell responses is critical for eliciting long-lasting immunity following viral infection and vaccination. A multitude of inhibitory and stimulatory factors are induced following infection, and it is the compilation of these signals that quantitatively and qualitatively program the ensuing effector and memory T cell response. In response to lymphocytic choriomeningitis virus (L ...
DOI:
10.1073/pnas.0914500107
PubMed:
20133700
PubMed Central:
PMC2840337

3. IL- 10 enhances T cell survival and is associated with faster relapse in patients with inactive ulcerative colitis

Author:
Shaoxuan Wang; JinXuan Wang; Ran Ma; Shaofeng Yang; Tingting Fan; Jing Cao; Yang Wang; Wenbin Ma; Wenxiu Yang; Fulai Wang; Honghao Zhang
Source:
Molecular immunology 2020 v.121 pp. 92-98
ISSN:
0161-5890
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; blood serum; cell proliferation; cell viability; interleukin-10; patients; relapse; remission; ulcerative colitis
Abstract:
... Ulcerative colitis (UC) is characterized by a relapsing and remitting pattern. The remission phase may last weeks to years. It remains unclear what specific factors can cause the disease to exist the remission phase and enter an activated state. IL-10 is a cytokine best known for its anti-inflammatory roles. We hypothesized that IL-10 might have a role in suppressing disease flares in UC remission ...
DOI:
10.1016/j.molimm.2020.03.001

4. IL- 15 induces strong but short-lived tumor-infiltrating CD8 T cell responses through the regulation of Tim-3 in breast cancer

Author:
Elise K. Heon; Hasi Wulan; Loch P. Macdonald; Adel O. Malek; Glenn H. Braunstein; Connie G. Eaves; Mark D. Schattner; Peter M. Allen; Michael O. Alexander; Cynthia A. Hawkins; Dermot W. McGovern; Richard L. Freeman; Eitan P. Amir; Jason D. Huse; Jeffrey S. Zaltzman; Noah P. Kauff; Paul G. Meyers; Michelle H. Gleason; Michael G. Overholtzer; Sam S. Wiseman; Catherine D. Streutker; Sylvia W. Asa; Timothy P. McAlindon; Polly O. Newcomb; Poul M. Sorensen; Oliver A. Press
Source:
Biochemical and biophysical research communications 2015 v.464 pp. 360-366
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; antibodies; apoptosis; breast neoplasms; cell culture; cell proliferation; interferon-gamma; interleukin-10; interleukin-15; interleukin-2; therapeutics
Abstract:
... IL-15 has pivotal roles in the control of CD8+ memory T cells and has been investigated as a therapeutic option in cancer therapy. Although IL-15 and IL-2 share many functions together, including the stimulation of CD8 T cell proliferation and IFN-γ production, the different in vivo roles of IL-15 and IL-2 have been increasingly recognized. Here, we explored the different effects of IL-15 and IL-2 ...
DOI:
10.1016/j.bbrc.2015.06.162

5. IL- 15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo

Author:
Huntington, Nicholas D.; Alves, Nuno L.; Legrand, Nicolas; Lim, Annick; Strick-Marchand, Helene; Mention, Jean-Jacques; Plet, Ariane; Weijer, Kees; Jacques, Yannick; Becker, Pablo D.; Guzman, Carlos; Soussan, Patrick; Kremsdorf, Dina; Spits, Hergen; Di Santo, James P.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.15 pp. 6217-6222
ISSN:
0027-8424
Subject:
B-lymphocytes; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; bioavailability; homeostasis; humans; immunization; interleukin-15; memory; mice; natural killer cells; neoplasms; neutralizing antibodies; phenotype; vaccines; viruses
Abstract:
... Cytokine immunotherapies targeting T lymphocytes are attractive clinical interventions against viruses and tumors. In the mouse, the homeostasis of memory α/β CD8⁺ T cells and natural killer (NK) cells is significantly improved with increased IL-15 bioavailability. In contrast, the role of "transpresented" IL-15 on human T-cell development and homeostasis in vivo is unknown. We found that both CD8 ...
DOI:
10.1073/pnas.1019167108
PubMed:
21444793
PubMed Central:
PMC3076818

6. IL- 15.IL-15Rα complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells

Author:
Fella Tamzalit; Isabelle Barbieux; Ariane Plet; Julie Heim; Steven Nedellec; Sébastien Morisseau; Yannick Jacques; Erwan Mortier
Source:
Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.23 pp. 8565-8570
ISSN:
0027-8424
Subject:
CD8-positive T-lymphocytes; interleukin-15; models; proteolysis
Abstract:
... Interleukin (IL)-15 and its specific receptor chain, IL-15Rα, support the development of various effector cells, including NK and CD8 T cells via a mechanism called trans -presentation. Whereas the dynamic of trans -presentation has been shown to involve the recycling of IL-15Rα by presenting cells, the way responding cells integrate, or take advantage of this process has not been evaluated yet. T ...
DOI:
10.1073/pnas.1405514111
PubMed:
24912180
PubMed Central:
PMC4060713

7. 16α-Bromo-epiandrosterone therapy modulates experimental feline immunodeficiency virus viremia: initial enhancement leading to long-term suppression

Author:
Pedersen, Niels C.; North, Thomas W.; Rigg, Richard; Reading, Chris; Higgins, Joanne; Leutenegger, Christian; Henderson, Gary L.
Source:
Veterinary immunology and immunopathology 2003 v.94 no.3-4 pp. 133-148
ISSN:
0165-2427
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Feline immunodeficiency virus; Human immunodeficiency virus 1; antibodies; antigens; antiviral properties; cats; chemokine CCL5; drugs; feces; hemocyanin; interferon-gamma; interleukin-10; interleukin-12; interleukin-4; interleukin-6; messenger RNA; metabolites; mice; mortality; neutrophils; pharmacokinetics; prasterone; therapeutics; urine; viral load; viremia; viruses
Abstract:
... 16α-Bromo-epiandrosterone (epiBr), a synthetic derivative of the natural hormone dehyroepiandrosterone (DHEA), was evaluated for its effects on feline immunodeficiency virus (FIV) infection in experimental cats. The rationale for this study was based on the ability of DHEA to significantly reduce the mortality to viral infections in mice. DHEA and epiBr also have demonstrable in vitro anti-viral a ...
DOI:
10.1016/S0165-2427(03)00081-3

8. IL‐ 1α and inflammasome‐independent IL‐1β promote neutrophil infiltration following alum vaccination

Author:
Ewa Oleszycka; Hannah B.T. Moran; Graham A. Tynan; Claire H. Hearnden; Graham Coutts; Matthew Campbell; Stuart M. Allan; Christopher J. Scott; Ed C. Lavelle
Source:
FEBS journal 2016 v.283 no.1 pp. 9-24
ISSN:
1742-464X
Subject:
CD8-positive T-lymphocytes; adaptive immunity; alum; antibodies; caspase-1; cathepsin S; dendritic cells; eosinophils; humans; injection site; innate immunity; interleukin-1alpha; interleukin-1beta; macrophages; monocytes; neutrophils; ovalbumin; secretion; vaccination; vaccines
Abstract:
... Despite its long record of successful use in human vaccines, the mechanisms underlying the immunomodulatory effects of alum are not fully understood. Alum is a potent inducer of interleukin‐1 (IL‐1) secretion in vitro in dendritic cells and macrophages via Nucleotide‐binding domain and leucine‐rich repeat‐containing (NLR) family, pyrin domain‐containing 3 (NLRP3) inflammasome activation. However, ...
DOI:
10.1111/febs.13546

9. IL- 2 immunotherapy in chronically SIV-infected Rhesus Macaques

Author:
Julie Garibal; Mireille Laforge; Ricardo Silvestre; Shahul Mouhamad; Laure Campillo-Gimenez; Yves Lévy; Jérôme Estaquier
Source:
Virology journal 2012 v.9 no.1 pp. 220
ISSN:
1743-422X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; HIV infections; Human immunodeficiency virus; Macaca mulatta; animals; antiretroviral agents; apoptosis; clinical trials; dose response; immunotherapy; interleukin-2; patients; viral load; wasting syndrome
Abstract:
... BACKGROUND: Despite inducing a sustained increase in CD4+ T cell counts, intermittent recombinant IL-2 (rIL-2) therapy did not confer a better clinical outcome in HIV-infected patients enrolled in large phase III clinical trials ESPRIT and SILCAAT. Several hypotheses were evoked to explain these discrepancies. Here, we investigated the impact of low and high doses of IL-2 in Rhesus macaques of Chi ...
DOI:
10.1186/1743-422X-9-220

10. IL- 21 Is Required to Control Chronic Viral Infection

Author:
Elsaesser, Heidi; Sauer, Karsten; Brooks, David G.
Source:
Science 2009 v.324 no.5934 pp. 1569-1572
ISSN:
0036-8075
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; animal models; chronic diseases; immunity; interleukin-21
Abstract:
... CD4⁺ and CD8⁺ T cell functions are rapidly aborted during chronic infection, preventing viral clearance. CD4⁺ T cell help is required throughout chronic infection so as to sustain CD8⁺ T cell responses; however, the necessary factor(s) provided by CD4⁺ T cells are currently unknown. Using a mouse model of chronic viral infection, we demonstrated that interleukin-21 (IL-21) is an essential componen ...
DOI:
10.1126/science.1174182
PubMed:
19423777
PubMed Central:
PMC2830017

11. IL- 21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

Author:
Fröhlich, Anja; Kisielow, Jan; Schmitz, Iwana; Freigang, Stefan; Shamshiev, Abdijapar T.; Weber, Jacqueline; Marsland, Benjamin J.; Oxenius, Annette; Kopf, Manfred
Source:
Science 2009 v.324 no.5934 pp. 1576-1580
ISSN:
0036-8075
Subject:
antigens; neoplasms; mice; Lymphocytic choriomeningitis mammarenavirus; viruses; homeostasis; immune response; interleukin-21; cell proliferation; CD8-positive T-lymphocytes
Abstract:
... Chronic viral infection is often associated with the dysfunction of virus-specific T cells. Our studies using Il21r-deficient (Il21r⁻/⁻) mice now suggest that interleukin-21 (IL-21) is critical for the long-term maintenance and functionality of CD8⁺ T cells and the control of chronic lymphocytic choriomeningitis virus infection in mice. Cell-autonomous IL-21 receptor (IL-21R)-dependent signaling b ...
DOI:
10.1126/science.1172815

12. IL- 23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis

Author:
Teng, Michele W.L.; Andrews, Daniel M.; McLaughlin, Nicole; von Scheidt, Bianca; Ngiow, Shin Foong; Möller, Andreas; Hill, Geoffrey R.; Iwakura, Yoichiro; Oft, Martin; Smyth, Mark J.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.18 pp. 8328-8333
ISSN:
0027-8424
Subject:
CD8-positive T-lymphocytes; adaptive immunity; animal models; carcinogenesis; fibrosarcoma; immune response; immunotherapy; inflammation; innate immunity; interferon-gamma; interleukin-12; interleukin-17; interleukin-2; interleukin-23; metastasis; mice; natural killer cells
Abstract:
... IL-23 is an important molecular driver of Th17 cells and has strong tumor-promoting proinflammatory activity postulated to occur via adaptive immunity. Conversely, more recently it has been reported that IL-17A elicits a protective inflammation that promotes the activation of tumor-specific CD8⁺ T cells. Here we show the much broader impact of IL-23 in antagonizing antitumor immune responses prima ...
DOI:
10.1073/pnas.1003251107
PubMed:
20404142
PubMed Central:
PMC2889517

13. 2B4⁺ CD8⁺ T cells play an inhibitory role against constrained HIV epitopes

Author:
Kim N. Aldy; Nathan C. Horton; Porunelloor A. Mathew; Stephen O. Mathew
Source:
Biochemical and biophysical research communications 2011 v.405 no.3 pp. 503-507
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; Human immunodeficiency virus; acquired immunodeficiency syndrome; cytotoxicity; disease course; epitopes; influenza; interferon-gamma; peptides; receptors; secretion; viruses
Abstract:
... Cytotoxic T cells play a critical role in the control of HIV and the progression of infected individuals to AIDS. 2B4 (CD244) is a member of the SLAM family of receptors that regulate lymphocyte development and function. The expression of 2B4 on CD8⁺ T cells was shown to increase during AIDS disease progression. However, the functional role of 2B4⁺ CD8⁺ T cells against HIV infection is not known. ...
DOI:
10.1016/j.bbrc.2011.01.062
PubMed:
21256826
PubMed Central:
PMC3063451

14. A 30-year journey of trial and error towards a tolerogenic AIDS vaccine

Author:
Jean-Marie Andrieu; Wei Lu
Source:
Archives of virology 2018 v.163 no.8 pp. 2025-2031
ISSN:
0304-8608
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; HIV infections; HIV long-term survivors; Human immunodeficiency virus; Lactobacillus plantarum; Lactobacillus rhamnosus; Macaca; Simian immunodeficiency virus; adjuvants; heterozygosity; humans; humoral immunity; immunosuppression; longevity; reverse transcription; therapeutics; vaccines; virus replication; viruses
Abstract:
... Since 1985, we have tested several immunological approaches to suppressing HIV replication in HIV-infected patients and to prevent HIV acquisition in uninfected people. Here, after briefly reviewing our studies on immunosuppressive treatments and therapeutic dendritic cell-based therapies, we examine in more detail our work on the tolerogenic vaccines we developed against AIDS in Chinese macaques. ...
DOI:
10.1007/s00705-018-3936-1
PubMed:
30043201
PubMed Central:
PMC6096718

15. IL- 32γ induces chemotaxis of activated T cells via dendritic cell-derived CCL5

Author:
Mi Hye Son; Mi Young Jung; Seulah Choi; Daeho Cho; Tae Sung Kim
Source:
Biochemical and biophysical research communications 2014 v.450 pp. 30-35
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; Crohn disease; antibodies; bioactive properties; cell movement; chemokine CCL2; chemokine CCL4; chemokine CCL5; chemotaxis; dose response; immune response; immunomodulators; interleukins; mitogen-activated protein kinase; neutralization; rheumatoid arthritis; transcription factor NF-kappa B; vasculitis
Abstract:
... Interleukin (IL)-32 has been associated with a variety of inflammatory diseases including rheumatoid arthritis, vasculitis and Crohn’s disease. We have previously reported that IL-32γ, the IL-32 isoform with the highest biological activity, could act as an immune modulator through regulation of dendritic cell (DC) functions in immune responses. Cell locomotion is crucial for induction of an effect ...
DOI:
10.1016/j.bbrc.2014.05.052

16. IL- 4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8+ T cell avidity following HIV-1 recombinant pox viral vaccination

Author:
Danushka K. Wijesundara; Ronald J. Jackson; David C. Tscharke; Charani Ranasinghe
Source:
Vaccine 2013 v.31 no.41 pp. 4548-4555
ISSN:
0264-410X
Subject:
CD8-positive T-lymphocytes; Human immunodeficiency virus 1; antibodies; interferon-gamma; interleukin-13; interleukin-2; interleukin-4; mice; neoplasms; signal transduction; transcription factors; tumor necrosis factors; vaccination; vaccines
Abstract:
... We have shown that mucosal HIV-1 recombinant pox viral vaccination can induce high, avidity HIV-specific CD8+ T cells with reduced interleukin (IL)-4 and IL-13 expression compared to, systemic vaccine delivery. In the current study how these cytokines act to regulate anti-viral CD8+ T, cell avidity following HIV-1 recombinant pox viral prime-boost vaccination was investigated. Out of a panel of T ...
DOI:
10.1016/j.vaccine.2013.07.062

17. IL- 6 induced proliferation and cytotoxic activity of CD8+ T cells is elevated by SUMO2 overexpression

Author:
Yun-Jung Lee; Tae Joon Won; Kyeong Eun Hyung; Ye Won Jang; Soo Jeong Kim; Do Ik Lee; So-Young Park; Kwang Woo Hwang
Source:
Archives of pharmacal research 2016 v.39 no.5 pp. 705-712
ISSN:
0253-6269
Subject:
CD8-positive T-lymphocytes; adaptive immunity; autoimmune diseases; cytotoxicity; gene expression; hypersensitivity; interleukin-6; neoplasm cells; neoplasms; pathogens; phosphatidylinositol 3-kinase; proteins; signal transduction
Abstract:
... T cells play an important role in adaptive immune responses that destroy pathogens or infected cells. Therefore, regulation of T cell activity is important in various diseases, such as autoimmune diseases, hypersensitivity, and cancer. The conjugation of small ubiquitin-related modifier (SUMO) is a post-translational protein modification that regulates activity, stability, and subcellular transloc ...
DOI:
10.1007/s12272-016-0736-6

18. IL- 6, NLR, and SII Markers and Their Relation with Alterations in CD8+ T-Lymphocyte Subpopulations in Patients Treated for Lung Adenocarcinoma

Author:
Lorenzo Islas-Vazquez; Dolores Aguilar-Cazares; Miriam Galicia-Velasco; Uriel Rumbo-Nava; Manuel Meneses-Flores; Cesar Luna-Rivero; Jose Sullivan Lopez-Gonzalez
Source:
Biology 2020 v.9 no.11 pp. -
ISSN:
2079-7737
Subject:
CD8-positive T-lymphocytes; adenocarcinoma; biopsy; carcinogenesis; drug therapy; flow cytometry; immunohistochemistry; interleukin-6; lungs; memory; neoplasm cells; nucleoproteins; patients; population
Abstract:
... Cytokines, key contributors to tumorigenesis, are mediators between inflammatory immune or nonimmune and cancer cells. Here, IL-6 production by tumor cells was assessed in a cohort of patients with lung adenocarcinoma treated with conventional therapy. IL-6 levels and neutrophil–lymphocyte ratio (NLR) or systemic immune-inflammation index (SII) markers were evaluated. Changes in pro- and anti-infl ...
DOI:
10.3390/biology9110376

19. IL- 7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity

Author:
Guoliang Cui; Matthew M. Staron; Simon M. Gray; Ping-Chih Ho; Robert A. Amezquita; Jingxia Wu; Susan M. Kaech
Source:
Cell 2015 v.161 pp. 750-761
ISSN:
0092-8674
Subject:
CD8-positive T-lymphocytes; aquaporins; cell viability; esterification; fatty acids; glycerol; humans; immunity; interleukin-7; longevity; metabolism; mice; triacylglycerols
Abstract:
... Memory T cells are critical for long-term immunity against reinfection and require interleukin-7 (IL-7), but the mechanisms by which IL-7 controls memory T cell survival, particularly metabolic fitness, remain elusive. We discover that IL-7 induces expression of the glycerol channel aquaporin 9 (AQP9) in virus-specific memory CD8+ T cells, but not naive cells, and that AQP9 is vitally required for ...
DOI:
10.1016/j.cell.2015.03.021
PubMed:
25957683
PubMed Central:
PMC4704440

20. 70-kDa heat shock protein coated magnetic nanocarriers as a nanovaccine for induction of anti-tumor immune response in experimental glioma

Author:
Maxim A. Shevtsov; Boris P. Nikolaev; Liudmila Y. Yakovleva; Marina A. Parr; Yaroslav Y. Marchenko; Igor Eliseev; Anna Yudenko; Anatolii V. Dobrodumov; Olga Zlobina; Alexander Zhakhov; Alexander M. Ischenko; Emil Pitkin; Gabriele Multhoff
Source:
Journal of Controlled Release 2015 v.220 pp. 329-340
ISSN:
0168-3659
Subject:
CD8-positive T-lymphocytes; adenosinetriphosphatase; blood serum; coatings; cytotoxicity; enzyme activity; heat-shock protein 70; immune response; immunization; immunostimulants; magnetic resonance imaging; magnetism; memory; nanocarriers; nanoparticles; neoplasms; nuclear magnetic resonance spectroscopy; peptides; phosphorus; rats; secretion; stable isotopes
Abstract:
... Nanovaccines based on superparamagnetic iron oxide nanoparticles (SPIONs) provide a novel approach to induce the humoral and cell-based immune system to fight cancer. Herein, we increased the immunostimulatory capacity of SPIONs by coating them with recombinant heat shock protein 70 (Hsp70) which is known to chaperone antigenic peptides. After binding, Hsp70–SPIONs deliver immunogenic peptides fro ...
DOI:
10.1016/j.jconrel.2015.10.051

21. IL- 9-producing CD8+ T cells represent a distinctive subset with different transcriptional characteristics from conventional CD8+ T cells, and partially infiltrate breast tumors

Author:
Pengpeng Ding; Rui Zhu; Bo Cai; Jun Zhang; Qingao Bu; Di-Wen Sun
Source:
international journal of biochemistry & cell biology 2019 pp. 105576
ISSN:
1357-2725
Subject:
CD8-positive T-lymphocytes; breast neoplasms; immunity; interferon-gamma; interleukin-17; interleukin-2; interleukin-9; patients; receptors; secretion; transcription (genetics)
Abstract:
... Accumulating evidence suggests that IL-9 and IL-9-producing cells exert various roles in antitumor immunity. Our study examined the IL-9 production in CD8+ T cells from breast cancer patients as compared to healthy controls. IL-9 secretion was undetectable in CD8+ T cells ex vivo, but could be readily detected following anti-TCR or PMA + ionomycin stimulation, and was higher in breast cancer patie ...
DOI:
10.1016/j.biocel.2019.105576

22. A24 Session 7: Advances in Thermal Medicine

Author:
Fumito Ito; Jason Muhitch; Mark Bucsek; Sharon S. Evans
Source:
Cryobiology 2014 v.69 no.1 pp. 190
ISSN:
0011-2240
Subject:
CD8-positive T-lymphocytes; adaptive immunity; adjuvants; antigens; apoptosis; colorectal neoplasms; drug therapy; immunotherapy; inflammation; lymph nodes; medicine; melanoma; mice; models; neoplasm cells; radiotherapy; temperature
Abstract:
... It is becoming increasingly clear that tumor control by standard chemotherapy and radiotherapy as well as high- and low-temperature ablative modalities depend on the CD8 T cell-mediated adaptive immune response. Unfortunately, in many cases the ability of these therapies to activate the endogenous CD8 T cell response is not sufficient to induce durable protection from tumor outgrowth. Here, we rep ...
DOI:
10.1016/j.cryobiol.2014.06.033

23. AKT/SGK-sensitive phosphorylation of GSK3 in the regulation of L-selectin and perforin expression as well as activation induced cell death of T-lymphocytes

Author:
Shefalee K. Bhavsar; Katja Merches; Diwakar Bobbala; Florian Lang
Source:
Biochemical and biophysical research communications 2012 v.425 no.1 pp. 6-12
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; alanine; cell death; cell viability; consensus sequence; cytokines; encephalitis; glycogen synthase kinases; lithium; mice; mutants; phosphorylation; serine
Abstract:
... Survival and function of T-lymphocytes critically depends on phosphoinositide (PI) 3 kinase. PI3 kinase signaling includes the PKB/Akt and SGK dependent phosphorylation and thus inhibition of glycogen synthase kinase GSK3α,β. Lithium, a known unspecific GSK3 inhibitor protects against experimental autoimmune encephalomyelitis. The present study explored, whether Akt/SGK-dependent regulation of GSK ...
DOI:
10.1016/j.bbrc.2012.07.030

24. ART-Treated Patients Exhibit an Adaptive Immune Response against the HFVAC Peptides, a Potential HIV-1 Therapeutic Vaccine (Provir/Latitude45 Study)

Author:
Hervé Fleury; Sabrina Caldato; Patricia Recordon-Pinson; Patricia Thebault; Gwenda-Line Guidicelli; Mojgan Hessamfar; Philippe Morlat; Fabrice Bonnet; Jonathan Visentin
Source:
Viruses 2020 v.12 no.11 pp. -
ISSN:
1999-4915
Subject:
CD8-positive T-lymphocytes; DNA; Human immunodeficiency virus 1; Whites; adaptive immunity; alleles; antiretroviral agents; cytotoxicity; epitopes; flow cytometry; immune response; patients; peptides; therapeutics; vaccines
Abstract:
... We proposed a new HIV-1 therapeutic vaccine based on conserved cytotoxic T lymphocyte (CTL) epitopes of archived HIV-1 DNA according to their affinity to the dominant HLA-A and -B alleles of the population investigated. Our proposal (Hla Fitted VAC, HFVAC) was composed of 15 peptides originating from the RT, gag and nef parts of proviral DNA. Our aim was to investigate baseline immune reactivity t ...
DOI:
10.3390/v12111256

25. AT₁ receptor-mediated angiotensin II activation and chemotaxis of T lymphocytes

Author:
João Luiz Silva-Filho; Mariana Conceição Souza; Maria das Graças Henriques; Alexandre Morrot; Wilson Savino; Marise Pinheiro Nunes; Celso Caruso-Neves; Ana Acacia Sá Pinheiro
Source:
Molecular immunology 2011 v.48 no.15-16 pp. 1835-1843
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; adhesion; angiotensin II; angiotensin-converting enzyme inhibitors; antagonists; cell adhesion; chemotaxis; fibronectins; immunity; laminin; receptors; renin-angiotensin system
Abstract:
... Angiotensin II (Ang II), a central renin–angiotensin system (RAS) effector molecule, and its receptors, AT₁ and AT₂, have been shown to be involved in the inflammatory aspects of different diseases, however the cellular mechanisms underlying the regulation of immunity are not fully understood. In this work, using spleen-derived CD4⁺ and CD8⁺ T lymphocytes activated in vitro, we tested the influenc ...
DOI:
10.1016/j.molimm.2011.05.008

26. Ablation of core fucosylation attenuates the signal transduction via T cell receptor to suppress the T cell development

Author:
Wei Liang; Shanshan Mao; Ming Li; Nianzhu Zhang; Shijie Sun; Hui Fang; Jianing Zhang; Jianguo Gu; Jingyu Wang; Wenzhe Li
Source:
Molecular immunology 2019 v.112 pp. 312-321
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; apoptosis; glycoproteins; glycosylation; mice; phosphorylation; receptors; signal transduction; thymocytes; thymus gland; transferases
Abstract:
... Precise glycosylation plays a crucial and distinctive role in thymic T cell development. The core fucosylation is dramatically up-regulated at the transition from CD4−CD8− (DN) to CD4+CD8+ (DP) in the thymic development. Ablation of core fucosylation in T cells did reduce the size of the thymus due to a significant loss of CD4+ SP, CD8+ SP and DP thymocytes in core fucosyltransferase (Fut8) knocko ...
DOI:
10.1016/j.molimm.2019.06.011

27. Ablation of thymic export causes accelerated decay of naïve CD4 T cells in the periphery because of activation by environmental antigen

Author:
Bourgeois, Christine; Hao, Zhenyue; Rajewsky, Klaus; Potocnik, Alexandre J.; Stockinger, Brigitta
Source:
Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.25 pp. 8691-8696
ISSN:
0027-8424
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; HIV infections; Human immunodeficiency virus; antigens; digestive system; homeostasis; microbial load; models; phenotype; thymus gland
Abstract:
... A model of chemical thymectomy by inducible Rag ablation was used to study peripheral T cell homeostasis. Induction of Rag ablation was efficient and complete, leading to cessation of thymic T cell production within 3-4 weeks. The decay of peripheral T cells became apparent with a delay of an additional 2-3 weeks and was entirely accounted for by loss of naïve T cells, whereas numbers of memory ph ...
DOI:
10.1073/pnas.0803732105
PubMed:
18562288
PubMed Central:
PMC2438401

28. Accumulation of Plasmodium berghei-Infected Red Blood Cells in the Brain Is Crucial for the Development of Cerebral Malaria in Mice

Author:
Baptista, Fernanda G.; Pamplona, Ana; Pena, Ana C.; Mota, Maria M.; Pied, Sylviane; Vigário, Ana M.
Source:
Infection and immunity 2010 v.78 no.9 pp. 4033-4039
ISSN:
0019-9567
Subject:
CD8-positive T-lymphocytes; Plasmodium berghei; Plasmodium falciparum; brain; death; drugs; erythrocytes; human diseases; humans; malaria; mice; models; neurodevelopment; parasites; parasitism; pathogenesis
Abstract:
... Cerebral malaria is the most severe complication of human infection with Plasmodium falciparum. It was shown that Plasmodium berghei ANKA-induced cerebral malaria was prevented in 100% of mice depleted of CD8⁺ T cells 1 day prior to the development of neurological signs. However, the importance of parasites in the brains of these mice was never clearly investigated. Moreover, the relevance of this ...
DOI:
10.1128/IAI.00079-10
PubMed:
20605973
PubMed Central:
PMC2937458

29. Acetalated Dextran: A Tunable and Acid-Labile Biopolymer with Facile Synthesis and a Range of Applications

Author:
Bachelder Eric M.; Pino Erica N.; Ainslie Kristy M.
Source:
Chemical Reviews 2017 v.117 no.3 pp. 1915-1926
ISSN:
1520-6890
Subject:
CD8-positive T-lymphocytes; biopolymers; dextran; immunomodulation; immunomodulators; microparticles; models; molecular weight; nucleotides; ovalbumin; pH; therapeutics; vaccines
Abstract:
... Acetalated dextran (Ac-DEX) is a tunable acid-labile biopolymer with facile synthesis, aptly designed for the formulation of microparticles for vaccines and immune modulation. Tunability of degradation is achieved based on the kinetics of reaction and the molecular weight of the parent dextran polymer. This tunability translated to differential rates of activation of CD8+ T cells in an in vitro ov ...
DOI:
10.1021/acs.chemrev.6b00532

30. Acquired immunity and vaccination against infectious pancreatic necrosis virus of salmon

Author:
Hetron Mweemba Munang’andu; Stephen Mutoloki; Øystein Evensen
Source:
Developmental and comparative immunology 2014 v.43 no.2 pp. 184-196
ISSN:
0145-305X
Subject:
CD8-positive T-lymphocytes; Infectious pancreatic necrosis virus; Salmonidae; cytotoxicity; gene expression; humoral immunity; immunoglobulin M; salmon; vaccination; vaccines; viruses
Abstract:
... Acquired immunity plays an important role in the protection of salmonids vaccinated against infectious pancreatic necrosis virus (IPNV) infections. In recent years, vaccine research has taken a functional approach to find the correlates of protective immunity against IPNV infections. Accumulating evidence suggests that the humoral response, specifically IgM is a correlate of vaccine protection aga ...
DOI:
10.1016/j.dci.2013.08.008

31. Acquisition of immunity to the protozoan parasite Eimeria adenoeides in turkey poults and the peripheral blood leukocyte response to a primary infection

Author:
Gadde, U.; Chapman, H.D.; Rathinam, T.R.; Erf, G.F.
Source:
Poultry science 2009 v.88 no.11 pp. 2346-2352
ISSN:
0032-5791
Subject:
temporal variation; poults; oocysts; coccidiosis; basophils; monocytes; cell-mediated immunity; poultry diseases; animal pathogens; fecal egg count; liveweight gain; eosinophils; immunization; CD4-positive T-lymphocytes; heterophils; Eimeria adenoeides; CD8-positive T-lymphocytes
Abstract:
... A primary infection of 12.5 x 10³ oocysts of Eimeria adenoeides , given to 20-d-old turkey poults, resulted in depression of weight gain, and the production of large numbers of oocysts in the feces, compared with uninfected controls. Poults were raised under conditions to prevent possible reinfection to determine the ability of the primary infection to confer protective immunity against a challeng ...
DOI:
10.3382/ps.2009-00320
PubMed:
19834085

32. Activation and exhaustion of antigen-specific CD8+ T cells occur in different splenic compartments during infection with Plasmodium berghei

Author:
Ganchimeg Bayarsaikhan; Mana Miyakoda; Kazuo Yamamoto; Daisuke Kimura; Masoud Akbari; Masao Yuda; Katsuyuki Yui
Source:
Parasitology international 2017 v.66 no.3 pp. 227-235
ISSN:
1383-5769
Subject:
CD8-positive T-lymphocytes; Listeria monocytogenes; Plasmodium berghei; antigens; apoptosis; cytokines; immune response; listeriosis; malaria; mice; models; ovalbumin; parasites; pulp; receptors; spleen
Abstract:
... The spleen is the major organ in which T cells are primed during infection with malaria parasites. However, little is known regarding the dynamics of the immune responses and their localization within the splenic tissue during malaria infection. We examined murine CD8⁺ T cell responses during infection with Plasmodium berghei using recombinant parasites expressing a model antigen ovalbumin (OVA) p ...
DOI:
10.1016/j.parint.2017.01.022

33. Activation of T-Lymphocytes by LDL-Cholesterol

Author:
Arneth, Borros
Source:
Lipids 2009 v.44 no.4 pp. 311-316
ISSN:
0024-4201
Subject:
low density lipoprotein; cholesterol; immune response; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; lymphocyte proliferation; ascorbic acid; hypercholesterolemia; hypertension; human diseases; human health
Abstract:
... Native LDL-cholesterol can be mechanically stressed by strong vortexing. According to one hypothesis, mechanical shear stress within the vessel can lead to an aggregation of LDL-cholesterol and subsequently to activation of CD4 and CD8 T-lymphocytes. The goal of this study was to determine the proportion of activated CD4 and CD8 T-lymphocytes that is induced by adding unstressed and mechanically s ...
DOI:
10.1007/s11745-008-3273-3
PubMed:
19089481

34. Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice

Author:
Huai, Jisen; Firat, Elke; Nil, Ahmed; Million, Daniele; Gaedicke, Simone; Kanzler, Benoit; Freudenberg, Marina; van Endert, Peter; Kohler, Gabriele; Pahl, Heike L.; Aichele, Peter; Eichmann, Klaus; Niedermann, Gabriele
Source:
Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.13 pp. 5177-5182
ISSN:
0027-8424
Subject:
CD8-positive T-lymphocytes; apoptosis; cell senescence; fibroblasts; hematopoiesis; inflammation; knockout mutants; longevity; mice; neoplasm cells; phenotype; proteinases; transcription factor NF-kappa B
Abstract:
... The giant cytosolic protease tripeptidyl peptidase II (TPPII) has been implicated in the regulation of proliferation and survival of malignant cells, particularly lymphoma cells. To address its functions in normal cellular and systemic physiology we have generated TPPII-deficient mice. TPPII deficiency activates cell type-specific death programs, including proliferative apoptosis in several T line ...
DOI:
10.1073/pnas.0801413105
PubMed:
18362329
PubMed Central:
PMC2278225

35. Activation of dendritic cell function by soypeptide lunasin as a novel vaccine adjuvant

Author:
Chun-Yu Tung; David E. Lewis; Ling Han; Morayo Jaja; Shuyu Yao; Fang Li; Michael J. Robertson; Baohua Zhou; Jie Sun; Hua-Chen Chang
Source:
Vaccine 2014 v.32 no.42 pp. 5411-5419
ISSN:
0264-410X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Influenza A virus; adaptive immunity; adjuvants; amino acids; antigens; chemokine CCL3; chemokine CCL4; dendritic cells; genes; growth retardation; humans; immune response; immunization; immunomodulators; innate immunity; interleukin-6; mice; ovalbumin; soybeans; vaccines
Abstract:
... The addition of an appropriate adjuvant that activates the innate immunity is essential to subsequent development of the adaptive immunity specific to the vaccine antigens. Thus, any innovation capable of improving the immune responses may lead to a more efficacious vaccine. We recently identified a novel immune modulator using a naturally occurring seed peptide called lunasin. Lunasin was origina ...
DOI:
10.1016/j.vaccine.2014.07.103

36. Activation of naturally occurring lung CD4⁺CD25⁺ regulatory T cells requires CD8 and MHC I interaction

Author:
Joetham, Anthony; Takeda, Katsuyuki; Miyahara, Nobuaki; Matsubara, Shigeki; Ohnishi, Hiroshi; Koya, Toshiyuki; Dakhama, Azzeddine; Gelfand, Erwin W.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.38 pp. 15057-15062
ISSN:
0027-8424
Subject:
CD8-positive T-lymphocytes; antibodies; coculture; inflammation; interleukin-10; lungs; mice; transforming growth factor beta
Abstract:
... Naturally occurring Foxp3⁺CD4⁺CD25⁺ T cells (nTregs) isolated from lungs of naive mice regulate allergic airway hyperresponsiveness (AHR) and inflammation. Here, we demonstrate the critical requirement for engagement of MHC class I on CD4⁺CD25⁺ T cells by CD8 for the functional activation of these nTregs. Suppression of allergen-induced AHR and inflammation by nTregs was abolished in mice treated ...
DOI:
10.1073/pnas.0706765104
PubMed:
17855564
PubMed Central:
PMC1986612

37. Activation of protective cell-mediated immune response in gastric mucosa during Cryptosporidium muris infection and re-infection in immunocompetent mice

Author:
Marie Jalovecká; Bohumil Sak; Martin Kváč; Dana Květoňová; Zuzana Kučerová; Jiří Salát
Source:
Parasitology research 2010 v.106 no.5 pp. 1159-1166
ISSN:
0932-0113
Subject:
CD8-positive T-lymphocytes; Cryptosporidium muris; cell-mediated immunity; cryptosporidiosis; enzyme-linked immunosorbent assay; flow cytometry; gastric mucosa; hosts; immune response; mice; parasites; splenocytes
Abstract:
... Gastric cryptosporidia only inhabit the glandular part of the stomach of all age categories of their hosts and can cause chronic life-long infections independent of a host's immune status. The immune response in the stomach mucosa during the primary infection and re-infection with Cryptosporidium muris (TS03 and CB03) in immunocompetent BALB/c mice was characterized using flow cytometry analysis a ...
DOI:
10.1007/s00436-010-1785-2
PubMed:
20155366

38. Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8⁺ T cell

Author:
James E. D. Thaventhiran; Anja Hoffmann; Lukasz Magiera; Maike de la Roche; Holger Lingel; Monika Brunner-Weinzierl; Douglas T. Fearon
Source:
Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.33 pp. E2223
ISSN:
0027-8424
Subject:
CD8-positive T-lymphocytes; antigens; cytotoxicity; interleukin-2; ligands; transcription (genetics)
Abstract:
... During the primary response, the commitment of the CD8 ⁺ T cell to Blimp-1 expression and the terminal differentiation that Blimp-1 induces must be timed so as not to impair the process of clonal expansion. We determined whether the Hippo pathway, which links cell–cell contact to differentiation in other cell lineages, controls Blimp-1 expression. Activating the CD8 ⁺ T cell with antigen and IL-2 ...
DOI:
10.1073/pnas.1209115109
PubMed:
22745171
PubMed Central:
PMC3421161

39. Actively induced antigen-specific CD8⁺ T cells by epitope-bearing parasite pre-infection but not prime/boost virus vector vaccination could ameliorate the course of Plasmodium yoelii blood-stage infection

Author:
Takeshi Ono; Yoko Yamaguchi; Takemi Oguma; Eiji Takayama; Yasuhiro Takashima; Takushi Tadakuma; Yasushi Miyahira
Source:
Vaccine 2012 v.30 no.44 pp. 6270-6278
ISSN:
0264-410X
Subject:
CD8-positive T-lymphocytes; Plasmodium yoelii; Trypanosoma; Vaccinia virus; epitopes; erythrocytes; malaria; mice; monoclonal antibodies; parasites; protective effect; secondary immunization; vaccination; vaccine development; vaccines; viruses
Abstract:
... The lack of MHC molecules on red blood cells (RBCs) has led to questions regarding the immunological function of CD8⁺ T cells against malarial blood-stage (MBS). However, several recent reports contradicting with this concept have suggested that they play an important role in the course of MBS infection. The present study generated genetically engineered murine malaria, Plasmodium yoelii, which ex ...
DOI:
10.1016/j.vaccine.2012.08.009

40. Acute in vivo exposure to interferon-γ enables resident brain dendritic cells to become effective antigen presenting cells

Author:
Gottfried-Blackmore, Andres; Kaunzner, Ulrike W.; Idoyaga, Juliana; Felger, Judit C.; McEwen, Bruce S.; Bulloch, Karen
Source:
Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.49 pp. 20918-20923
ISSN:
0027-8424
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; adaptive immunity; brain; chimerism; dendritic cells; interferon-gamma; interleukin-4; mice; neuroglia; transgenic animals
Abstract:
... Dendritic cells (DC) are the professional antigen presenting cells (APC) that bridge the innate and adaptive immune system. Previously, in a CD11c/EYFP transgenic mouse developed to study DC functions, we anatomically mapped and phenotypically characterized a discrete population of EYFP⁺ cells within the microglia that we termed brain dendritic cells (bDC). In this study, we advanced our knowledge ...
DOI:
10.1073/pnas.0911509106
PubMed:
19906988
PubMed Central:
PMC2791588

41. Adaptive Immune Responses, Immune Escape and Immune-Mediated Pathogenesis during HDV Infection

Author:
Valerie Oberhardt; Maike Hofmann; Robert Thimme; Christoph Neumann-Haefelin
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
CD8-positive T-lymphocytes; HLA antigens; Hepatitis B virus; Hepatitis C virus; Hepatitis delta virus; Human immunodeficiency virus; adaptive immunity; humans; interferons; liver cirrhosis; mixed infection; pathogenesis; satellite viruses; vertebrate viruses
Abstract:
... The hepatitis delta virus (HDV) is the smallest known human virus, yet it causes great harm to patients co-infected with hepatitis B virus (HBV). As a satellite virus of HBV, HDV requires the surface antigen of HBV (HBsAg) for sufficient viral packaging and spread. The special circumstance of co-infection, albeit only one partner depends on the other, raises many virological, immunological, and pa ...
DOI:
10.3390/v14020198

42. Addition of C3d-P28 adjuvant to a rabies DNA vaccine encoding the G5 linear epitope enhances the humoral immune response and confers protection

Author:
Guillermo Galvez-Romero; Mónica Salas-Rojas; Ericka N. Pompa-Mera; Karina Chávez-Rueda; Álvaro Aguilar-Setién
Source:
Vaccine 2018 v.36 no.2 pp. 292-298
ISSN:
0264-410X
Subject:
epitopes; neutralization; polypeptides; survival rate; Rabies lyssavirus; adjuvants; lethal dose 50; humoral immunity; rabies; models; mice; spleen; viruses; neutralizing antibodies; immune response; recombinant vaccines; glycoproteins; CD8-positive T-lymphocytes
Abstract:
... Rabies DNA vaccines based on full-length glycoprotein (G) induce virus neutralizing antibody (VNA) responses and protect against the virus challenge. Although conformational epitopes of G are the main target of VNAs, some studies have shown that a polypeptide linear epitope G5 is also able to induce VNAs. However, a G5 DNA vaccine has not been explored. While multiple doses of DNA vaccines are req ...
DOI:
10.1016/j.vaccine.2017.11.047

43. Adenovirus type 35-vectored tuberculosis vaccine has an acceptable safety and tolerability profile in healthy, BCG-vaccinated, QuantiFERON®-TB Gold (+) Kenyan adults without evidence of tuberculosis

Author:
Douglas S. Walsh; Victorine Owira; Mark Polhemus; Lucas Otieno; Ben Andagalu; Bernhards Ogutu; John Waitumbi; Anthony Hawkridge; Barbara Shepherd; Maria Grazia Pau; Jerald Sadoff; Macaya Douoguih; J. Bruce McClain; the Aeras C-012-402 Study Team
Source:
Vaccine 2016 v.34 no.21 pp. 2430-2436
ISSN:
0264-410X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Mycobacterium tuberculosis; adults; creatine kinase; cytokines; immunodominant epitopes; injection site; neutralizing antibodies; neutropenia; pain; screening; staining; throat; tuberculosis; urine; vaccination; vaccines
Abstract:
... In a Phase 1 trial, we evaluated the safety of AERAS-402, an adenovirus 35-vectored TB vaccine candidate expressing 3 Mycobacterium tuberculosis (Mtb) immunodominant antigens, in subjects with and without latent Mtb infection. HIV-negative, BCG-vaccinated Kenyan adults without evidence of tuberculosis, 10 QuantiFERON®-TB Gold In-Tube test (QFT-G)(−) and 10 QFT-G(+), were randomized 4:1 to receive ...
DOI:
10.1016/j.vaccine.2016.03.069

44. Adjuvant Treatment with Yupingfeng Formula for Recurrent Respiratory Tract Infections in Children: A Meta‐analysis of Randomized Controlled Trials

Author:
Tao Song; Xiaoli Hou; Xiaohui Yu; Zhen Wang; Ruiren Wang; Yanling Li; Dan Hu; Xiaohong Wang; Zhengzheng Xiao; Yong Sui; Chunhong Zhu; Jing Wang
Source:
Phytotherapy research 2016 v.30 no.7 pp. 1095-1103
ISSN:
0951-418X
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; adjuvants; blood serum; children; confidence interval; databases; immunoglobulin A; immunoglobulin G; immunoglobulin M; meta-analysis; patients; randomized clinical trials; relative risk; respiratory rate; respiratory tract diseases
Abstract:
... This meta‐analysis aimed to evaluate the immunomodulating function of Yupingfeng Formula (YPFF) in children with recurrent respiratory tract infections (RRTIs). The PubMed, EMBASE, Cochrane Library, CNKI and WanFang databases were searched for randomized controlled trials comparing with and without YPFF for RRTIs in children. Twelve trials with 1236 patients were identified. Adjuvant treatment wit ...
DOI:
10.1002/ptr.5628

45. Adjuvant potential of archaeal synthetic glycolipid mimetics critically depends on the glyco head group structure

Author:
Sprott, G. Dennis; Dicaire, Chantal J.; Côté, Jean-Philippe; Whitfield, Dennis M.
Source:
Glycobiology 2008 v.18 no.7 pp. 559-565
ISSN:
0959-6658
Subject:
Archaea; CD8-positive T-lymphocytes; adjuvants; antigens; cytotoxicity; disaccharides; glucose; glycolipids; immune response; isoprenoids; mammals; neoplasms; pathogens; subunit vaccines
Abstract:
... Subunit vaccines capable of providing protective immunity against the intracellular pathogens and cancers that kill millions of people annually require an adjuvant capable of directing a sufficiently potent cytotoxic T lymphocyte response to purified antigens, without toxicity issues. Archaeosome lipid vesicles, prepared from isoprenoid lipids extracted from archaea, are one such adjuvant in devel ...
DOI:
10.1093/glycob/cwn038

46. Adjuvanted inactivated influenza A(H3N2) vaccines induce stronger immunogenicity in mice and confer higher protection in ferrets than unadjuvanted inactivated vaccines

Author:
Julie Ann; Mukesh Samant; Chantal Rheaume; Carole Dumas; Edith Beaulieu; Audrey Morasse; Corey Mallett; Marie-Eve Hamelin; Barbara Papadopoulou; Guy Boivin
Source:
Vaccine 2014 v.32 no.43 pp. 5730-5739
ISSN:
0264-410X
Subject:
CD8-positive T-lymphocytes; Influenza A virus; adjuvants; antibodies; ferrets; humoral immunity; immune response; immunization; immunoglobulin A; immunoglobulin G; inactivated vaccines; influenza; interferon-gamma; interleukin-2; interleukin-4; mice; nose; pathogens; temperature; viral load; weight loss
Abstract:
... Influenza viruses are major respiratory pathogens and the development of improved vaccines to prevent these infections is of high priority. Here, we evaluated split inactivated A(H3N2) vaccines (A/Uruguay/716/2007) combined or not with adjuvants (AS03, AS25 and Protollin) and administered by three different routes, intramuscular (i.m.), intranasal (i.n.) or intradermal (i.d.), both in BALB/c mice ...
DOI:
10.1016/j.vaccine.2014.08.029

47. Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii

Author:
Kamal El Bissati; Aziz A. Chentoufi; Paulette A. Krishack; Ying Zhou; Stuart Woods; Jitender P. Dubey; Lo Vang; Joseph Lykins; Kate E. Broderick; Ernest Mui; Yasuhiro Suzuki; Qila Sa; Stephanie Bi; Nestor Cardona; Shiv K. Verma; Laura Frazeck; Catherine A. Reardon; John Sidney; Jeff Alexander; Alessandro Sette; Tom Vedvick; Chris Fox; Jeffrey A. Guderian; Steven Reed; Craig W. Roberts; Rima McLeod
Source:
JCI insight 2016 v.1 no.15 pp. 1-18
ISSN:
2379-3708
Subject:
CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; HLA antigens; Toll-like receptor 4; Toxoplasma gondii; antigen presentation; disease prevention; emulsions; endocytosis; epitopes; immune response; immunogenicity; interferon-gamma; ligands; major histocompatibility complex; mice; parasite load; protective effect; protozoan antigens; protozoan vaccines; recombinant vaccines; toxoplasmosis; transgenic animals; vaccination; vaccine adjuvants
Abstract:
... We created and tested multi-epitope DNA or protein vaccines with TLR4 ligand emulsion adjuvant (gluco glucopyranosyl lipid adjuvant in a stable emulsion [GLA-SE]) for their ability to protect against Toxoplasma gondii in HLA transgenic mice. Our constructs each included 5 of our best down-selected CD8+ T cell–eliciting epitopes, a universal CD4+ helper T lymphocyte epitope (PADRE), and a secretory ...
Handle:
10113/6961195
DOI:
10.1172/jci.insight.85955

48. Adjuvanticity of aqueous extracts of Artemisia rupestris L. for inactivated foot-and-mouth disease vaccine in mice

Author:
Danyang Wang; Hui Cao; Jinyao Li; Bin Zhao; Yan Wang; Ailian Zhang; Jiong Huang
Source:
Research in veterinary science 2019 v.124 pp. 191-199
ISSN:
0034-5288
Subject:
Artemisia rupestris; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Foot-and-mouth disease virus; abnormal behavior; adjuvants; adverse effects; antibody formation; cell-mediated immunity; death; dendritic cells; foot-and-mouth disease; immunoglobulin G; interferon-gamma; interleukin-4; mice; splenocytes; vaccines
Abstract:
... Several methods have been developed to improve the efficacy of foot-and-mouth disease virus (FMDV) vaccine. The study aims to determine whether aqueous extracts of Artemisia rupestris L. (AEAR) as an immunoactivator in combination with inactivated FMDV vaccine can promote immune responses in mice. Intramuscular co-immunization in ICR mice with different doses of AEAR plus FMDV vaccine could substa ...
DOI:
10.1016/j.rvsc.2019.03.016

49. Adjuvants targeting innate and adaptive immunity synergize to enhance tumor immunotherapy

Author:
Verdeil, Grégory; Marquardt, Kristi; Surh, Charles D.; Sherman, Linda A.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.43 pp. 16683-16688
ISSN:
0027-8424
Subject:
CD8-positive T-lymphocytes; adaptive immunity; adjuvants; antigens; cytokines; immunotherapy; innate immunity; irradiation; neoplasms; vaccines
Abstract:
... Because of mechanisms of self-tolerance, many tumor-specific CD8 T cells exhibit low avidity for tumor antigens and would benefit from strategies that enhance their numbers and effector function. Here we demonstrate that the combined use of two different types of immune adjuvants, one that directly targets the CD8 cell, IL-2/anti-IL-2 mAb complexes, and one that targets the innate immune system, p ...
DOI:
10.1073/pnas.0805054105
PubMed:
18936481
PubMed Central:
PMC2575480

50. Adjuvants that stimulate TLR3 or NLPR3 pathways enhance the efficiency of influenza virus-like particle vaccines in aged mice

Author:
Kirsten Schneider-Ohrum; Brendan M. Giles; Heather K. Weirback; Brianne L. Williams; Dilhari R. DeAlmeida; Ted M. Ross
Source:
Vaccine 2011 v.29 no.48 pp. 9081-9092
ISSN:
0264-410X
Subject:
CD8-positive T-lymphocytes; Orthomyxoviridae; Toll-like receptors; adjuvants; alum; blood serum; dendritic cells; elderly; immune response; influenza; lungs; mice; vaccination; virus-like particle vaccines; virus-like particles
Abstract:
... There is intense interest in the design and use of vaccine strategies against influenza to enhance protective immune responses in the elderly. To address the need for improved influenza vaccines for the aged, two inflammatory adjuvants, Imject® alum (a stimulator of the Nod-like receptor, Nalp3) and poly I:C (a toll-like receptor type 3 ligand), were used during vaccination with novel influenza vi ...
DOI:
10.1016/j.vaccine.2011.09.051
PubMed:
21963872
PubMed Central:
PMC6690196