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1. Aeromonas salmonicida aptamer selection and construction for colorimetric and ratiometric fluorescence dual-model aptasensor combined with g-C3N4 and G-quadruplex

Author:
Qiujun Lu; Shengnan Zhang; Yuzhen Ouyang; Chun Zhang; Meiling Liu; Youyu Zhang; Le Deng
Source:
Talanta 2023 v.252 pp. 123857
ISSN:
0039-9140
Subject:
Aeromonas salmonicida; Danio rerio; aptasensors; aquaculture; color; colorimetry; detection limit; early diagnosis; fluorescence; food safety; oligonucleotides; opportunistic pathogens; rapid methods; single-stranded DNA; systematic evolution of ligands by exponential enrichment
Abstract:
... Aeromonas salmonicida (A. salmonicida) is an important opportunistic pathogen to aquatic animals that causes severe economic losses to aquaculture, which makes its rapid detection and prevention are critical. In this work, a single-stranded DNA (ssDNA) aptamer (A.s-2) with high specificity to the bacteria was selected by Systematic Evolution of Ligands by Exponential Enrichment (SELEX). The select ...
DOI:
10.1016/j.talanta.2022.123857

2. Anti-inflammatory and immunostimulant effect of different timing-related administration of dietary polyphenols on intestinal inflammation in zebrafish, Danio rerio

Author:
Roberta Imperatore; Graziella Orso; Serena Facchiano; Pierpaolo Scarano; Seyed Hossein Hoseinifar; Ghasem Ashouri; Carmine Guarino; Marina Paolucci
Source:
Aquaculture 2023 v.563 pp. 738878
ISSN:
0044-8486
Subject:
Castanea sativa; Danio rerio; Verbascum; adults; antioxidant activity; antioxidants; aquaculture; assets; catalase; diet; feed additives; flavonoids; gene expression; immunostimulants; inflammation; interleukin-10; intestines; mitogen-activated protein kinase; models; phosphorylation; polyphenols; prostaglandin synthase; superoxide dismutase; transcription factor NF-kappa B; tumor necrosis factors
Abstract:
... A short-term study was performed to assess the effects of diets supplemented with polyphenols (CSVP), extracted from the chestnut (Castanea sativa) shell, agri-food waste rich in tannins, and mullein (Verbascum macrurum), a perennial spontaneous plant rich in flavonoids, on a zebrafish (Danio rerio) model of k-carrageenan-induced intestinal inflammation. Morphological asset of intestine, immunoden ...
DOI:
10.1016/j.aquaculture.2022.738878

3. Developmental toxicity of TCBPA on the nervous and cardiovascular systems of zebrafish (Danio rerio): A combination of transcriptomic and metabolomics

Author:
Wentao Liu; Yifan Pan; Lu Yang; Yun Xie; Xuanyue Chen; Jing Chang; Weiyu Hao; Lifei Zhu; Bin Wan
Source:
Journal of environmental sciences (China) 2023 v.127 pp. 197-209
ISSN:
1001-0742
Subject:
Danio rerio; blood; developmental toxicity; flame retardants; focal adhesions; humans; metabolomics; transcriptomics; China
Abstract:
... Tetrachlorobisphenol A (TCBPA), a widely used halogenated flame retardant, is frequently detected in environmental compartments and human samples. However, unknown developmental toxicity and mechanisms limit the entire understanding of its effects. In this study, zebrafish (Danio rerio) embryos were exposed to various concentrations of TCBPA while a combination of transcriptomics, behavioral and b ...
DOI:
10.1016/j.jes.2022.04.022

4. Exposure of zebrafish (Danio rerio) to trans-2-hexenal induces oxidative stress and protein degeneration of the gill

Author:
Dicheng Ma; Haiyan Yu; Guangrui Cui; Jiamei Zhu; Bingyu Zhu; Wei Mu; Feng Liu
Source:
Science of the total environment 2023 v.854 pp. 158813
ISSN:
0048-9697
Subject:
Danio rerio; biopesticides; cell death; chronic toxicity; denaturation; environment; intravenous injection; malondialdehyde; methionine; mortality; oral administration; oxidative stress; protein denaturation; risk; risk assessment; succinate dehydrogenase (quinone)
Abstract:
... Trans-2-hexenal (T2H) has great commercial value for development as a biopesticide, but its toxicity risk to nontarget organisms is unknown. Here, the toxicity and underlying mechanism of T2H on zebrafish (Danio rerio) were investigated. The LC₅₀ (48 h) of T2H on zebrafish is 4.316 μg/mL, and the aldehyde group is essential to its toxicity. In 14-day chronic toxicity tests, 0.432 μg/mL T2H resulte ...
DOI:
10.1016/j.scitotenv.2022.158813

5. Global warming and glyphosate toxicity (II): Offspring zebrafish modelling with behavioral, morphological and immunohistochemical approaches

Author:
Ekrem Sulukan; Alper Baran; Meryem Kankaynar; Tuğba Kızıltan; İsmail Bolat; Serkan Yıldırım; Hacer Akgül Ceyhun; Saltuk Buğrahan Ceyhun
Source:
Science of the total environment 2023 v.856 pp. 158903
ISSN:
0048-9697
Subject:
Danio rerio; adults; apoptosis; aquatic ecosystems; blood flow; environment; fish; glyphosate; heart rate; immunohistochemistry; lipids; locomotion; models; mouth; progeny; reactive oxygen species; serotonin; survival rate; temperature; thigmotaxis; toxicity
Abstract:
... The increase in temperature due to global warming greatly affects the toxicity produced by pesticides in the aquatic ecosystem. Studies investigating the effects of such environmental stress factors on next generations are important in terms of the sustainability of ecosystems. In this study, the effects of parental synergistic exposure to glyphosate and temperature increase on the next generation ...
DOI:
10.1016/j.scitotenv.2022.158903

6. Mepanipyrim induces cardiotoxicity of zebrafish (Danio rerio) larvae via promoting AhR-regulated COX expression pathway

Author:
Chao Shen; Jing He; Kongyang Zhu; Naying Zheng; Yue Yu; Chengyong He; Chunyan Yang; Zhenghong Zuo
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 650-661
ISSN:
1001-0742
Subject:
Danio rerio; agonists; antagonists; bioassays; calcium; cardiomyocytes; cardiotoxicity; electron transport chain; gene expression; heart rate; human health; mepanipyrim; mitochondria; toxicity; viticulture; China
Abstract:
... The wide use of pesticides has seriously threatened human health and the survival of beneficial organisms. The fungicide mepanipyrim is widely used in viticulture practices. Studies of mepanipyrim-induced toxicity in organisms are still scarce, especially studies on cardiotoxicity. In this study, we aimed to investigate mepanipyrim-induced cardiotoxicity in zebrafish (Danio rerio) larvae. We found ...
DOI:
10.1016/j.jes.2022.01.012

7. Mepanipyrim induces visual developmental toxicity and vision-guided behavioral alteration in zebrafish larvae

Author:
Chao Shen; Yimei Cai; Jialing Li; Chengyong He; Zhenghong Zuo
Source:
Journal of environmental sciences (China) 2023 v.124 pp. 76-88
ISSN:
1001-0742
Subject:
Danio rerio; anilinopyrimidine fungicides; aryl hydrocarbon receptors; developmental toxicity; fruit growing; fungi; genes; light intensity; mepanipyrim; opsin; phototransduction; quantitative polymerase chain reaction; transcriptomics; wavelengths; China
Abstract:
... Mepanipyrim, an anilinopyrimidine fungicide, has been extensively used to prevent fungal diseases in fruit culture. Currently, research on mepanipyrim-induced toxicity in organisms is still very scarce, especially visual developmental toxicity. Here, zebrafish larvae were employed to investigate mepanipyrim-induced visual developmental toxicity. Intense light and monochromatic light stimuli-evoked ...
DOI:
10.1016/j.jes.2021.11.008

8. Nuclease treatment enhances the probiotic effect of Bacillus velezensis T23 on hepatic steatosis and inflammation induced by high-fat diet in zebrafish

Author:
Fengli Zhang; Yinyin Luan; Qiang Hao; Qingshuang Zhang; Yalin Yang; Chao Ran; Zhen Zhang; Zhigang Zhou
Source:
Aquaculture 2023 v.562 pp. 738801
ISSN:
0044-8486
Subject:
Bacillus velezensis; Danio rerio; antioxidant activity; aquaculture; complement; fatty liver; fermented foods; high fat diet; immunity; inflammation; interleukin-6; intestinal microorganisms; intestines; lipogenesis; liver; lysozyme; mucus; nucleotides; probiotics; weight gain
Abstract:
... Metabolic diseases caused by high-fat diet (HFD) have been a major problem currently in aquaculture. Nucleotides have been used as functional nutrients to improve the growth and health of fish，such as stimulating immune responses, such as immune cells and complement lytic activity. In this experiment, we supplemented solid fermentation product of Bacillus velezensis T23 and nuclease-treated Bacill ...
DOI:
10.1016/j.aquaculture.2022.738801

9. Nucleus-targeting pH-Responsive carbon dots for fast nucleus pH detection

Author:
Samran Durrani; Zihuayuan Yang; Jie Zhang; Zihao Wang; Haiyan Wang; Faran Durrani; Fu-Gen Wu; Fengming Lin
Source:
Talanta 2023 v.252 pp. 123855
ISSN:
0039-9140
Subject:
Alzheimer disease; Danio rerio; RNA; carbon; cell nucleolus; endocytosis; fluorescence; heart diseases; light intensity; lipids; pH; photoluminescence
Abstract:
... Nucleus pH is closely linked to many diseases such as aging, heart disease, skeletal myopathies, cancer, Alzheimer's disease, etc. Nevertheless, fluorescent sensors that can directly monitor nucleus pH changes have not yet been reported. Here, we first reported a green emissive carbon dots (CDs) for nucleus pH detection in living cells. CDs can selectively target nucleus with high accumulation at ...
DOI:
10.1016/j.talanta.2022.123855

10. Parental and transgenerational impairments of thyroid endocrine system in zebrafish by 2,4,6-tribromophenol

Author:
Yuxi Zhou; Juanjuan Fu; Min Wang; Yongyong Guo; Lihua Yang; Jian Han; Bingsheng Zhou
Source:
Journal of environmental sciences (China) 2023 v.124 pp. 291-299
ISSN:
1001-0742
Subject:
Danio rerio; adults; bioaccumulation; brain; chemical analysis; flame retardants; histopathology; humans; liver; pollution; progeny; toxicity; transcription (genetics); China
Abstract:
... Many environmental contaminants could be transmitted from parents and generate impairments to their progeny. The 2,4,6-tribromophenol (TBP), a novel brominated flame retardant which has been frequently detected in various organisms, was supposed to be bioaccumulated and intergenerational transmitted in human beings. Previous studies revealed that TBP could disrupt thyroid endocrine system in zebra ...
DOI:
10.1016/j.jes.2021.09.022

11. Pathogenic infection and microbial composition of yellow catfish (Pelteobagrus fulvidraco) challenged by Aeromonas veronii and Proteus mirabilis

Author:
Wanying Zhai; Qian Wang; Xinpeng Zhu; Xiaoying Jia; Liangbiao Chen
Source:
Aquaculture and fisheries 2023 v.8 no.2 pp. 166-173
ISSN:
2468-550X
Subject:
Aeromonas veronii; Danio rerio; Ictalurus punctatus; Moraxella; Proteus mirabilis; Tachysurus fulvidraco; Vibrio; bacterial communities; catfish; disease prevention; freshwater fish; intraperitoneal injection; microbiome; mortality; mucus; pathogenicity; China
Abstract:
... The catfishes are a group of economically important freshwater fish in China, which in recent years have suffered heavy losses as a result of bacterial outbreaks. In this study, we examined the diversity of the microbiome of infected skin mucus of yellow catfish (Pelteobagrus fulvidraco) and channel catfish (Ictalurus punctatus) and analyzed the bacterial pathogens. We found several common pathoge ...
DOI:
10.1016/j.aaf.2021.05.007

12. Silica crystals activate toll-like receptors and inflammasomes to promote local and systemic immune responses in zebrafish

Author:
Sylwia D. Tyrkalska; Annamaria Pedoto; Alicia Martínez-López; José A. Ros-Lucas; Pablo Mesa-del-Castillo; Sergio Candel; Victoriano Mulero
Source:
Developmental and comparative immunology 2023 v.138 pp. 104523
ISSN:
0145-305X
Subject:
Danio rerio; brain; immune system; immunology; inflammasomes; inflammation; models; pyroptosis; respiratory tract diseases; silica
Abstract:
... Silica crystals are potent activators of the inflammasome that cause a fibrotic lung disease, called silicosis, with no effective treatment available. We report here that injection of silica crystals into the hindbrain ventricle of zebrafish embryos led to the initiation of local and systemic immune responses driven through both Toll-like receptors (TLR)- and inflammasome-dependent signaling pathw ...
DOI:
10.1016/j.dci.2022.104523

13. TLR5M cooperates with TLR5S to activate NF-κB in Nile tilapia (Oreochromis niloticus)

Author:
Zijiong Dong; Jiadong Li; Ruhuang Deng; Zhenzhen Zhang; Jianlin Chen; Yang Lei; Liting Wu; Zheng Guo; Bei Wang; Bingxi Li; Fang Liang; Jianmin Ye
Source:
Aquaculture 2023 v.562 pp. 738775
ISSN:
0044-8486
Subject:
Aeromonas hydrophila; Danio rerio; Oreochromis niloticus; Toll-like receptor 5; aquaculture; brain; cell membranes; cytokines; disease prevention; fish; flagellin; kidneys; liver; macrophages; monocytes; pathogens; spleen
Abstract:
... The binding of flagellin to receptor TLR5 (Toll-like receptor 5) on the cell surface is a prerequisite for the pathogen infection to the body, which has important implication for disease prevention. Unlike mammals, teleost TLR5 exists in two different forms: membrane-bound TLR5M (membrane TLR5, TLR5M) and secreted TLR5S (soluble TLR5, TLR5S). In this study, TLR5M and TLR5S from Nile tilapia (Oreoc ...
DOI:
10.1016/j.aquaculture.2022.738775

14. Tocopherol-assisted magnetic Ag-Fe3O4-TiO2 nanocomposite for photocatalytic bacterial-inactivation with elucidation of mechanism and its hazardous level assessment with zebrafish model

Author:
Rajaiah Alexpandi; Gurusamy Abirami; Balaji Murugesan; Ravindran Durgadevi; Roshni Prithiviraj Swasthikka; Yurong Cai; Thennarasu Ragupathi; Arumugam Veera Ravi
Source:
Journal of hazardous materials 2023 v.442 pp. 130044
ISSN:
0304-3894
Subject:
Danio rerio; bacterial contamination; biochemical pathways; cell membranes; death; magnetism; models; nanocomposites; nanomaterials; oxidative stress; photocatalysis; photocatalysts; proteomics; seawater; solar radiation; toxicity; water treatment
Abstract:
... In recent years, many endeavours have been prompted with photocatalytic nanomaterials by the need to eradicate pathogenic microorganisms from water bodies. Herein, a tocopherol-assisted Ag-Fe₃O₄-TiO₂ nanocomposite (TAFTN) was synthesized for photocatalytic bacterial inactivation. The prepared TAFTN became active under sunlight due to its narrowed bandgap, inactivating the bacterial contaminants vi ...
DOI:
10.1016/j.jhazmat.2022.130044

15. Transcriptome reveals overview of Ca2+ dose-dependent metabolism disorders in zebrafish larvae after Cd2+ exposure

Author:
Biran Zhu; Ziniu Wang; Lei Lei; Yongyong Guo; Jian Han; Bingsheng Zhou
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 480-491
ISSN:
1001-0742
Subject:
Danio rerio; cadmium; calcium; dose response; gene expression regulation; heavy metals; lipid metabolism; remission; toxicity; toxicology; transcriptome; water hardness; China
Abstract:
... Cadmium (Cd), a ubiquitous environmental hazardous heavy metal, poses a significant threat to the health of aquatic organisms, including teleosts. Although the toxic profile of Cd is well recognized, little is known regarding the overall view of toxic responses to varying aquatic environmental parameters (e.g., water hardness) at an individual level. Herein, differences in water hardness were part ...
DOI:
10.1016/j.jes.2021.12.009

16. Variability in fecal metabolome depending on age, PFBS pollutant, and fecal transplantation in zebrafish: A non-invasive diagnosis of health

Author:
Baili Sun; Mengyuan Liu; Lizhu Tang; Xiangzhen Zhou; Chenyan Hu; Lianguo Chen
Source:
Journal of environmental sciences (China) 2023 v.127 pp. 530-540
ISSN:
1001-0742
Subject:
Danio rerio; absorption; adults; amino acids; carbohydrates; digestion; early diagnosis; feces; intestinal microorganisms; lipids; metabolites; metabolome; metabolomics; neurotransmitters; pollutants; prediction; steroid hormones; synaptic transmission; therapeutics; toxicity; toxicology; China
Abstract:
... To protect the wellbeing of research animals, certain non-invasive measures are in increasing need to facilitate an early diagnosis of health and toxicity. In this study, feces specimen was collected from adult zebrafish to profile the metabolome fingerprint. Variability in fecal metabolite composition was also distinguished as a result of aging, perfluorobutanesulfonate (PFBS) toxicant, and fecal ...
DOI:
10.1016/j.jes.2022.06.019

17. A new ratiometric AIE fluorescent probe for detecting cysteine in food samples and imaging in the biological system

Author:
Shuai Gong; Ahui Qin; Yan Zhang; Mingxin Li; Xiaoyi Chen; Yueyin Liang; Xu Xu; Zhonglong Wang; Shifa Wang
Source:
Food chemistry 2023 v.400 pp. 134108
ISSN:
0308-8146
Subject:
Danio rerio; apples; bamboos; cabbage; cysteine; detection limit; dried milk; fluorescence; fluorescent dyes; food chemistry; food industry; garlic; liquids; milk; pears; wavelengths
Abstract:
... l-Cysteine (Cys) plays a vital part in the food industry and biological processes. Herein, a novel ratiometric fluorescent probe NFA with aggregation-induced emission (AIE) property was developed to discriminate Cys from Hcy and GSH. The probe showed a ratiometric fluorescence response to Cys with the emission wavelength shifted from 450 nm to 495 nm. Probe NFA possessed good advantages in the det ...
DOI:
10.1016/j.foodchem.2022.134108

18. 1,6-epi-Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal α-Glucosidase Stabilizer for the Treatment of Pompe Disease

Author:
Ken Kok; Chi-Lin Kuo; Rebecca E. Katzy; Lindsey T. Lelieveld; Liang Wu; Véronique Roig-Zamboni; Gijsbert A. van der Marel; Jeroen D. C. Codée; Gerlind Sulzenbacher; Gideon J. Davies; Herman S. Overkleeft; Johannes M. F. G. Aerts; Marta Artola
Source:
Journal of the American Chemical Society 2022 v.144 no.32 pp. 14819-14827
ISSN:
1520-5126
Subject:
Danio rerio; ceramide glucosyltransferase; diabetes; enzyme inhibitors; humans; intestines; lysosomes; stabilizers; therapeutics
Abstract:
... α-Glucosidase inhibitors are potential therapeutics for the treatment of diabetes, viral infections, and Pompe disease. Herein, we report a 1,6-epi-cyclophellitol cyclosulfamidate as a new class of reversible α-glucosidase inhibitors that displays enzyme inhibitory activity by virtue of its conformational mimicry of the substrate when bound in the Michaelis complex. The α-d-glc-configured cyclophe ...
DOI:
10.1021/jacs.2c05666

19. 5-HMF affects cardiovascular development in zebrafish larvae via reactive oxygen species and Wnt signaling pathways

Author:
Yu Jiang; Nan Geng; Mingyong Wang; Wen Wu; Ninghan Feng; Xian Zhang
Source:
Comparative biochemistry and physiology 2022 v.262 pp. 109452
ISSN:
1532-0456
Subject:
Danio rerio; Maillard reaction; acetylcysteine; angiogenesis; apoptosis; cytotoxicity; edema; fluorescence; gene expression; genes; genetically modified organisms; genotoxicity; heart rate; histology; hydroxymethylfurfural; neoplasms; pericardium; phenotype; quantitative analysis; reactive oxygen species; toxicity testing
Abstract:
... 5-Hydroxymethylfurfural (5-HMF) is a small molecule aldehyde compound produced by the Maillard reaction. As 5-HMF exists in a variety of foods and drugs and is easily ingested by humans, it has attracted extensive toxicological attention in recent years. Relevant research showed that 5-HMF has cytotoxicity, genotoxicity, and tumor effects. However, the cardiovascular effects of 5-HMF are unknown. ...
DOI:
10.1016/j.cbpc.2022.109452

20. 5-Hydroxymethyl-2-furaldehyde induces developmental toxicology and decreases bone mineralization in zebrafish larvae

Author:
Yu Jiang; Zhaomin Zhong; Mingyong Wang; Xian Zhang
Source:
Comparative biochemistry and physiology 2022 v.254 pp. 109254
ISSN:
1532-0456
Subject:
Danio rerio; acetylcysteine; bone mineralization; cartilage; developmental toxicity; enzyme activity; gene expression; hydroxymethylfurfural; mortality; reactive oxygen species; skeletal development; toxicology
Abstract:
... In this study, we aimed to assess the developmental toxicity and effects of 5-HMF in zebrafish as a model organism for toxicology studies. To this end, we treated zebrafish embryos with 1–100 μg/ml 5-HMF and observed bone staining, gene expression, and reactive oxygen species levels in order to investigate the toxicological effects of 5-HMF. The results showed that high concentrations of 5-HMF cau ...
DOI:
10.1016/j.cbpc.2021.109254