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1. Applications of lemon or cinnamon essential oils in strawberry fruit preservation: A review

Author:
Elise Freche; John Gieng; Giselle Pignotti; Salam A. Ibrahim; Xi Feng
Source:
Journal of food processing and preservation 2022 v.46 no.9 pp. e16526
ISSN:
0145-8892
Subject:
Botrytis cinerea; GRAS substances; cinnamon; essential oils; food loss; food preservation; fruits; lemons; strawberries; vapors; wastes
Abstract:
... Essential oils are currently being investigated for their potential role as fruit preservatives. They contain a mixture of bioactive compounds that would help preserve fruits without using synthetic chemicals. They can slow or inhibit many fungi and bacteria growth, including Botrytis cinerea, one of the primary pathogens responsible for fruit waste. Lemon and cinnamon essential oils are particula ...
DOI:
10.1111/jfpp.16526

2. Harnessing lactic acid bacteria in synthetic microbial consortia

Author:
Jian-Ming Liu; Christian Solem; Ting Lu; Peter Ruhdal Jensen
Source:
Trends in biotechnology 2022 v.40 no.1 pp. 8-11
ISSN:
0167-7799
Subject:
GRAS substances; biochemical pathways; biotechnology; exhibitions; lactic acid bacteria; sustainable agriculture
Abstract:
... Lactic acid bacteria (LAB) are important members in synthetic microbial consortia due to their ‘generally recognized as safe’ status and diverse metabolic activities. Defined communities with LAB show great potential in elucidating metabolic interactions that drive their assembly and demonstrating power to address sustainability challenges in food, environment, and health. ...
DOI:
10.1016/j.tibtech.2021.09.002

3. Process optimization for mass production of 2,3-butanediol by Bacillus subtilis CS13

Author:
Dexin Wang; Baek-Rock Oh; Sungbeom Lee; Dae-Hyuk Kim; Min-Ho Joe
Source:
Biotechnology for biofuels 2021 v.14 no.1 pp. 15
ISSN:
1754-6834
Subject:
Bacillus subtilis; GRAS substances; aeration; agitation; ammonium; batch fermentation; biofuels; biotechnology; carbon; citrates; glutamic acid; mass; molasses; pharmaceutical industry; response surface methodology; sucrose
Abstract:
... BACKGROUND: Bacillus subtilis CS13 was previously isolated for 2,3-butanediol (2,3-BD) and poly-γ-glutamic acid (γ-PGA) co-production. When culturing this strain without L-glutamic acid in the medium, 2,3-BD is the main metabolic product. 2,3-BD is an important substance and fuel with applications in the chemical, food, and pharmaceutical industries. However, the yield and productivity for the B. ...
DOI:
10.1186/s13068-020-01859-w

4. Accurate glutamate monitoring in foodstuffs by a sensitive and interference-free glutamate oxidase based disposable amperometric biosensor

Author:
Annalisa Mentana; Donatella Nardiello; Carmen Palermo; Diego Centonze
Source:
Analytica chimica acta 2020 v.1115 pp. 16-22
ISSN:
0003-2670
Subject:
GRAS substances; L-glutamate oxidase; analytical chemistry; biosensors; bovine serum albumin; detection limit; electrodes; flavor; food matrix; foods; glutamic acid; glutaraldehyde; immobilized enzymes; monitoring; platinum; pyrroles
Abstract:
... L-Glutamate (L-Glu) is a well-known flavour enhancer that is present in several foodstuffs. Although L-Glu is generally recognized as safe, the use in foodstuffs remains controversial and then its fast and accurate monitoring represents an important issue. In this work a sensitive and interference-free disposable amperometric biosensor for glutamate monitoring in foodstuffs was developed. The bios ...
DOI:
10.1016/j.aca.2020.04.020

5. Aggregation-prone peptides modulate activity of bovine interferon gamma released from naturally occurring protein nanoparticles

Author:
José Vicente Carratalá; Olivia Cano-Garrido; Julieta Sánchez; Cristina Membrado; Eudald Pérez; Oscar Conchillo-Solé; Xavier Daura; Alejandro Sánchez-Chardi; Antonio Villaverde; Anna Arís; Elena Garcia-Fruitós; Neus Ferrer-Miralles
Source:
New biotechnology 2020 v.57 pp. 11-19
ISSN:
1871-6784
Subject:
GRAS substances; Lactococcus lactis; bioactive properties; biopharmaceuticals; cattle; interferon-gamma; microorganisms; models; nanoparticles; peptides; physicochemical properties; protein aggregates; protein content; recombinant proteins; therapeutics
Abstract:
... Efficient protocols for the production of recombinant proteins are indispensable for the development of the biopharmaceutical sector. Accumulation of recombinant proteins in naturally-occurring protein aggregates is detrimental to biopharmaceutical development. In recent years, the view of protein aggregates has changed with the recognition that they are a valuable source of functional recombinant ...
DOI:
10.1016/j.nbt.2020.02.001

6. Biocatalytic strategies for the production of ginsenosides using glycosidase: current state and perspectives

Author:
Wei-Na Li; Dai-Di Fan
Source:
Applied microbiology and biotechnology 2020 v.104 no.9 pp. 3807-3823
ISSN:
0175-7598
Subject:
Escherichia coli; GRAS substances; Oriental traditional medicine; Panax ginseng; Saccharomyces cerevisiae; aerobic conditions; antineoplastic activity; antineoplastic agents; biocatalysis; biotransformation; engineering; enzymes; fermentation; food industry; fungi; genes; ginsenosides; health services; industrial applications; moieties; pharmaceutical industry; probiotics; protein engineering; solvents
Abstract:
... Panax ginseng is a traditional Chinese medicine with significant pharmaceutical effects and broad application. Rare ginsenosides with high antitumor activities can be generated via oriented modification of their glycosyl moiety. For this purpose, suitable microorganisms and their enzymatic systems can be used. In this review, we address several issues associated with these systems. Under aerobic c ...
DOI:
10.1007/s00253-020-10455-9

7. The Biosynthesis Mechanism Involving 2,3-Pentanedione and Aminoacetone Describes the Production of 2-Ethyl-3,5-dimethylpyrazine and 2-Ethyl-3,6-dimethylpyrazine by Bacillus subtilis

Author:
Huaizhi Zhang; Lijie Zhang; Xiaowei Yu; Yan Xu
Source:
Journal of agricultural and food chemistry 2020 v.68 no.11 pp. 3558-3567
ISSN:
1520-5118
Subject:
Bacillus subtilis; GRAS substances; ambient temperature; biosynthesis; fermentation; glucose; industrial applications; isotope labeling; metabolites; nuts; odors; pyrazines; threonine
Abstract:
... 2-Ethyl-3,5(3,6)-dimethylpyrazines (EDMPs) have a pleasant aroma of roasted cocoa or nuts with an extreme low odor threshold that have potential in industrial applications as food fragrances. The food fermentation process can accumulate EDMPs, and this might be the chance to study the biosynthesis mechanism of EDMPs under mild conditions for “natural” EDMPs’ production. In this study, an EDMP-prod ...
DOI:
10.1021/acs.jafc.9b07809

8. Caenorhabditis elegans as an in vivo model to assess fucoidan bioactivity preventing Helicobacter pylori infection

Author:
Carla Palacios-Gorba; Raquel Pina; Miguel Tortajada-Girbés; Ana Jiménez-Belenguer; Érica Siguemoto; Maria Antonia Ferrús; Dolores Rodrigo; Maria Consuelo Pina-Pérez
Source:
Food & function 2020 v.11 no.5 pp. 4525-4534
ISSN:
2042-650X
Subject:
Caenorhabditis elegans; Fucus vesiculosus; GRAS substances; Helicobacter pylori; Macrocystis pyrifera; Undaria pinnatifida; algae; antibacterial properties; antibiotics; carcinogens; dietary supplements; digestive tract; exposure duration; fucoidan; infection; longevity; models; oviposition; pathogens; research; therapeutics
Abstract:
... Currently, Helicobacter pylori is the unique biological carcinogenic agent. The search for antimicrobial alternatives to antibiotics against this pathogen has been categorized as a priority due to the drastic failure associated with current applied antibiotic therapy. The present study assessed the bioactive antimicrobial capability of fucoidan (“Generally Recognized as Safe” approval – European C ...
DOI:
10.1039/d0fo00768d

9. Changes in China’s carbon footprint and driving factors based on newly constructed time series input–output tables from 2009 to 2016

Author:
Hao Cai; Shaojian Qu; Meng Wang
Source:
Science of the total environment 2020 v.711 pp. 134555
ISSN:
0048-9697
Subject:
GRAS substances; carbon; carbon dioxide; carbon footprint; emissions factor; energy; entropy; exports; greenhouse gas emissions; international trade; issues and policy; system optimization; technological change; time series analysis; China
Abstract:
... China is the country with the most carbon emissions and the largest foreign trade volume worldwide. China’s carbon footprint, especially the carbon footprint of exports, must be studied to clarify China's responsibility for carbon emissions, avoid “carbon leakage” and develop more reasonable emission reduction policies. By comparing 6 update models, this paper adopts the GRAS, which is a typical e ...
DOI:
10.1016/j.scitotenv.2019.134555

10. Conjugated linoleic acid improves endothelial Ca2+ signaling by blocking growth factor and cytokine-mediated Cx43 phosphorylation

Author:
Amanda K. Mauro; Danielle M. Berdahl; Nauman Khurshid; Luca Clemente; Amanda C. Ampey; Dinesh M. Shah; Ian M. Bird; Derek S. Boeldt
Source:
Molecular and cellular endocrinology 2020 v.510 pp. 110814
ISSN:
0303-7207
Subject:
GRAS substances; adenosine triphosphate; calcium; calcium signaling; conjugated linoleic acid; connexins; growth factors; interleukin-6; phosphorylation; pre-eclampsia; pregnancy; tumor necrosis factor-alpha
Abstract:
... Sustained Ca²⁺ burst signaling is crucial for endothelial vasodilator production and is disrupted by growth factors and cytokines. Conjugated linoleic acid (CLA), a Src inhibitor in certain preparations, is generally regarded as safe during pregnancy by the FDA. Multiple CLA preparations; t10, c12 or c9, t11 CLA, or a 1:1 mixture of the two were administered before growth factor or cytokine treatm ...
DOI:
10.1016/j.mce.2020.110814

11. Development of Selenized Lactic Acid Bacteria and their Selenium Bioaccummulation Capacity

Author:
Gabriela Krausova; Antonin Kana; Ivana Hyrslova; Iva Mrvikova; Miloslava Kavkova
Source:
Fermentation 2020 v.6 no.3 pp. -
ISSN:
2311-5637
Subject:
Enterococcus faecium; GRAS substances; Streptococcus thermophilus; antioxidant activity; bioaccumulation; bioavailability; biotransformation; fermented dairy products; food industry; functional foods; human health; hydrophobicity; in vivo studies; industrial applications; knowledge; lactic acid bacteria; lactic fermentation; selenium; sodium selenite; strains; toxicity
Abstract:
... Selenized lactic acid bacteria (LAB) represent potentially safe and effective sources of selenium (Se), essential for human health, as lactic acid fermentation improves Se bioavailability and reduces its toxicity. LAB are generally recognized as safe (GRAS) and widely used in fermented dairy products. To facilitate selenized LAB implementation as a functional food, we developed and characterized n ...
DOI:
10.3390/fermentation6030091

12. Development of a low-temperature extrusion process for production of GRAS bioactive-polymer loaded compounds for targeting antimicrobial-resistant (AMR) bacteria

Author:
Kevin Masterson; Elaine Meade; Mary Garvey; Mark Lynch; Ian Major; Neil J. Rowan
Source:
Science of the total environment 2021 v.800 pp. 149545
ISSN:
0048-9697
Subject:
Escherichia coli; GRAS substances; Staphylococcus epidermidis; antibiotic resistance; bioactive compounds; chitosan; composite polymers; environment; extrusion; growth retardation; industry; methicillin-resistant Staphylococcus aureus; nisin; silver nitrate; temperature
Abstract:
... Antimicrobial resistance (AMR) is recognised globally as one of the greatest threats to human and animal health; thus, discovery of alternative antibacterial agents to address AMR is a priority challenge. This study constitutes the first report of a low-melting temperature, polymer- extrusion process for the smart delivery of thermally-sensitive antimicrobial bioactives, including generally-regard ...
DOI:
10.1016/j.scitotenv.2021.149545

13. Effect of N-terminal modification on the antimicrobial activity of nisin

Author:
Xuejian Yu; Naiyan Lu; Jiyue Wang; Zhe Chen; Chen Chen; Joe Mac Regenstein; Peng Zhou
Source:
Food control 2020 v.114 pp. 107227
ISSN:
0956-7135
Subject:
GRAS substances; Staphylococcus aureus; World Health Organization; antimicrobial peptides; antimicrobial properties; bacteria; chitosan; crosslinking; lipids; nisin
Abstract:
... Nisin, the only antimicrobial peptide that has GRAS (generally considered as safe) status from both WHO and FDA, has the potential to become an important natural antibiotic as bacteria become more resistant to traditional antibiotics. Many studies have focused on how modification of nisin affects antimicrobial activity. In this study, nisin and chitosan were crosslinked using genipin to modify the ...
DOI:
10.1016/j.foodcont.2020.107227

14. Effect of benzyl isothiocyanate encapsulated biocompatible nanoemulsion prepared via ultrasonication on microbial strains and breast cancer cell line MDA MB 231

Author:
Shivani Uppal; Pratibha Sharma; Rajendra Kumar; Khushwinder Kaur; Alka Bhatia; S.K. Mehta
Source:
Colloids and surfaces 2020 v.596 pp. 124732
ISSN:
0927-7757
Subject:
Brassicaceae; Escherichia coli; Fourier transform infrared spectroscopy; GRAS substances; Staphylococcus aureus; antimicrobial properties; benzyl isothiocyanate; bioavailability; biocompatibility; breast neoplasms; cell lines; cytotoxicity; dietary supplements; encapsulation; flow cytometry; hemolysis; hydrophobicity; ingredients; nanocarriers; nanoemulsions; neoplasm cells; odors; pH; rhamnolipids; toxicity testing; transmission electron microscopy; ultrasonic treatment; ultraviolet-visible spectroscopy
Abstract:
... Benzyl Isothiocyanate (BITC), a nutraceutical belonging to the mustard family exhibits excellent antitumor and antimicrobial properties. Despite its prodigious potential, the lacuna in the practical application is due to hydrophobicity, high volatility, receded bioavailability, and acute odor. Owing to the entrenched advantages of the nanostructured colloidal systems, a new rhamnolipid based nanoe ...
DOI:
10.1016/j.colsurfa.2020.124732

15. Effect of slightly acidic electrolyzed water on natural Enterobacteriaceae reduction and seed germination in the production of alfalfa sprouts

Author:
Chunling Zhang; Zhiyi Zhao; Gaoji Yang; Yiqi Shi; Yuyu Zhang; Chao Shi; Xiaodong Xia
Source:
Food microbiology 2021 v.97 pp. 103414
ISSN:
0740-0020
Subject:
GRAS substances; Salmonella; acidity; adverse effects; alfalfa; bacterial growth; chlorine; crop production; decontamination; disinfectants; electrolyzed water; microbial contamination; pH; pathogens; seed germination; seeds; soaking; sprouting; sprouts (food); water uptake
Abstract:
... Microbial contamination of sprouts commonly occurs because of the pathogens present on and in the seeds and the optimal conditions for bacteria growth provided during the germination and sprouting processes. This study examined the decontamination effect of slightly acidic electrolyzed water (SAEW), a ‘generally recognized as safe’ (GRAS) disinfectant, in the production process of alfalfa sprouts. ...
DOI:
10.1016/j.fm.2020.103414

16. Emulsion-filled hydrogels for food applications: influence of pH on emulsion stability and a coating on microgel protection

Author:
Karen Cristina Guedes Silva; Ana Isabel Bourbon; Lorenzo Pastrana; Ana Carla Kawazoe Sato
Source:
Food & function 2020 v.11 no.9 pp. 8331-8341
ISSN:
2042-650X
Subject:
GRAS substances; alginates; assays; bioactive compounds; biopolymers; digestion; droplets; electrostatic interactions; emulsions; encapsulation; gelatin; gelation; hydrogels; in vitro digestion; lipids; microgels; microparticles; mouth; oral administration; pH; pharmaceutical industry; phosphates; potato starch; quartz crystal microbalance
Abstract:
... Encapsulation structures for oral administration have been widely employed by the food, personal care, and pharmaceutical industries. Emulsion-filled microgels can be used to encapsulate bioactive compounds, allowing the entrapment of lipid droplets in biopolymer networks and promoting bioactive protection. The influence of pH and biopolymer concentration on the formation and structure of emulsion ...
DOI:
10.1039/d0fo01198c

17. Encapsulation of lycopene in emulsions and hydrogel beads using dual modified rice starch: Characterization, stability analysis and release behaviour during in-vitro digestion

Author:
Surangna Jain; Thunnalin Winuprasith; Manop Suphantharika
Source:
Food hydrocolloids 2020 v.104 pp. 105730
ISSN:
0268-005X
Subject:
GRAS substances; adsorption; alginates; antioxidants; bioavailability; emulsions; encapsulation; gastrointestinal system; hydrocolloids; hydrogels; hydrophobicity; in vitro digestion; lipid metabolism; lycopene; models; oil-water interface; oils; rice starch; storage temperature
Abstract:
... The application of lycopene, a potent antioxidant, is limited because of its hydrophobic nature and low chemical stability. To overcome this, different delivery systems, i.e. oil-in-water emulsions and alginate beads, have been synthesized in this study using modified rice starch for improving the stability of lycopene. Lycopene solution (in oil) was used as a control. Modified rice starch was use ...
DOI:
10.1016/j.foodhyd.2020.105730

18. Engineering a newly isolated Bacillus licheniformis strain for the production of (2R,3R)-butanediol

Author:
Chan Woo Song; Rathnasingh Chelladurai; Jong Myoung Park; Hyohak Song
Source:
Journal of industrial microbiology & biotechnology 2020 v.47 no.1 pp. 97-108
ISSN:
1367-5435
Subject:
Bacillus licheniformis; GRAS substances; batch fermentation; engineering; gene deletion; genes; homologous recombination; isomers; microorganisms; mutagenesis; mutants; plasmids; soil
Abstract:
... Several microorganisms can produce 2,3-butanediol (BDO), an industrially promising chemical. In this study, a Bacillus licheniformis named as 4071, was isolated from soil sample. It is a GRAS (generally recognized as safe) strain and could over-produce 2,3-BDO. Due to its mucoid forming characteristics, UV-random mutagenesis was carried out to obtain a mucoid-free strain, 4071-15. As a result, cap ...
DOI:
10.1007/s10295-019-02249-4

19. Enhancing production of microalgal biopigments through metabolic and genetic engineering

Author:
Dinesh Kumar Saini; Hillol Chakdar; Sunil Pabbi; Pratyoosh Shukla
Source:
Critical reviews in food science and nutrition 2020 v.60 no.3 pp. 391-405
ISSN:
1549-7852
Subject:
Cyanobacteria; GRAS substances; anti-inflammatory activity; antioxidants; biotic factors; carotenoids; genetic engineering; hormones; metabolites; microalgae; nutrition; pharmaceutical industry; temperature; ultraviolet radiation; vitamins
Abstract:
... The versatile use of biopigments in food, feed, cosmetic, pharmaceutical and analytical industries emphasized to find different and renewable sources of biopigments. Microalgae, including cyanobacteria, are becoming a potential candidate for pigment production as these have fast-growing ability, high pigment content, highly variable and also have “Generally recognized as safe” status. These algal ...
DOI:
10.1080/10408398.2018.1533518

20. Evaluation of pullulan‐based edible active coating methods on Rastali and Chakkarakeli bananas and their shelf‐life extension parameters studies

Author:
V. S. Ramakrishna Ganduri
Source:
Journal of food processing and preservation 2020 v.44 no.4 pp. e14378
ISSN:
0145-8892
Subject:
GRAS substances; Musa acuminata; Musa balbisiana; ascorbic acid; bananas; calcium chloride; color; edible coatings; edible films; emulsions; exopolysaccharides; fresh produce; fruit quality; fruits; fungi; growers; ingredients; lemon juice; markets; physicochemical properties; postharvest technology; profits and margins; pullulan; shelf life; sugar content; vegetables; weight loss
Abstract:
... Pullulan, a bio‐polysaccharide, is being currently known as an edible coating shelf‐life extension of fruits and vegetables. In this examination, edible coating method was optimized using the RSM technique and pullulan‐based active edible coating formulations with Calcium chloride (1% w/v) and lemon juice (2% v/v) were coated on the Rastali and Chakkarakeli bananas and put away at 25 ± 1°C, 70% RH ...
DOI:
10.1111/jfpp.14378