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You searched for: Subject Leucojum aestivum Remove constraint Subject: Leucojum aestivum Subject term Alzheimer disease Remove constraint Subject term: Alzheimer disease Subject term Leucojum aestivum Remove constraint Subject term: Leucojum aestivum
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1. Seasonal variation in alkaloid content, phenolic constituent and biological activities of some Leucojum aestivum L. populations in Turkey

Author:
Sina Cafer Demir; Arzu Birinci Yildirim; Arzu Ucar Turker; Ismail Eker
Source:
South African journal of botany 2022 v.147 pp. 713-723
ISSN:
0254-6299
Subject:
Alzheimer disease; COVID-19 infection; Leucojum aestivum; Severe acute respiratory syndrome coronavirus 2; ambient temperature; antibacterial properties; antioxidant activity; antioxidants; genotype; harvest date; lycorine; methanol; organic matter; phenols; seasonal variation; secondary metabolites
Abstract:
... Summer snowflake (Leucojum aestivum L.), a bulbous plant in the Amaryllidaceae family, is a well-known source of two pharmaceutically significant alkaloids: galanthamine that is used to treat Alzheimer's disease and lycorine that has potent antiviral properties, especially against SARS-CoV-2 (COVID-19). Environmental factors such as temperature, light, soil, and so on, as well as harvest time and ...
DOI:
10.1016/j.sajb.2022.03.004

2. Enhancement of alkaloid content (galanthamine and lycorine) and antioxidant activities (enzymatic and non-enzymatic) unders salt stress in summer snowflake (Leucojum aestivum L.)

Author:
Muhammed Tural Ates; Arzu Birinci Yildirim; Arzu Ucar Turker
Source:
South African journal of botany 2021 v.140 pp. 182-188
ISSN:
0254-6299
Subject:
Alzheimer disease; Leucojum aestivum; antimalarials; antioxidant activity; bioactive compounds; bulbs; catalase; free radicals; growth and development; lycorine; methanol; salt stress; salt tolerance; summer; superoxide dismutase; water content
Abstract:
... Summer snowflake (Leucojum aestivum L.) is a bulbous plant to the Amaryllidaceae family. L. aestivum is a Euro-Mediterranean region plant and is a well-known source of pharmacologically important alkaloids. Galanthamine is the major bioactive compound that is widely used in the treatment of neurological disorders, including Alzheimer's disease. Another alkaloid lycorine has antitumor, antimalarial ...
DOI:
10.1016/j.sajb.2021.04.016

3. Alkaloid Variability in Leucojum aestivum from Wild Populations

Author:
Liliya Georgievaa; Strahil Berkov; Violeta Kondakova; Jaume Bastida; Francesc Viladomat; Atanas Atanassov; Carles Codina
Source:
Zeitschrift für Naturforschung 2014 v.62 no.9-10 pp. 627-635
ISSN:
1865-7125
Subject:
Alzheimer disease; Leucojum aestivum; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; lycorine; summer; Bulgaria
Abstract:
... Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied s ...
DOI:
10.1515/znc-2007-9-1002

4. Influence of auxins on somatic embryogenesis and alkaloid accumulation in Leucojum aestivum callus

Author:
Agata Ptak; Anna Tahchy; Edyta Skrzypek; Tomasz Wójtowicz; Dominique Laurain-Mattar
Source:
Open life sciences 2013 v.8 no.6 pp. 591-599
ISSN:
2391-5412
Subject:
2,4-D; Alzheimer disease; Leucojum aestivum; alkaloids; auxins; bulbs; callus; callus culture; dicamba; explants; growing media; phenolic compounds; picloram; polyethylene glycol; somatic embryogenesis
Abstract:
... In vitro cultures of Leucojum aestivum are considered as an alternative for the production of galanthamine, which is used for the symptomatic treatment of Alzheimer’s disease. We studied the effects of auxins 2,4-dichlorophenoxyacetic acid (2,4-D), 4-amino-3,5,6-trichloropicolinic acid (picloram), 3,6-dichloro-o-anisic acid (dicamba) at concentrations of 25 and 50 µM on the induction of embryogeni ...
DOI:
10.2478/s11535-013-0160-y

5. The geographic isolation of Leucojum aestivum populations leads to divergation of alkaloid biosynthesis

Author:
Strahil Berkov; Lilija Georgieva; Violeta Kondakova; Francesc Viladomat; Jaume Bastida; Atanas Atanassov; Carles Codina
Source:
Biochemical systematics and ecology 2013 v.46 pp. 152-161
ISSN:
0305-1978
Subject:
Alzheimer disease; Leucojum aestivum; acetylcholinesterase; biosynthesis; chemotypes; gas chromatography; lycorine; mass spectrometry; medicine; mountains; Balearic Islands; Bulgaria; Danube River
Abstract:
... Leucojum aestivum, an industrial source of the acetylcholinesterase inhibitor galanthamine, shows a great chemodiversity in its alkaloid synthesis. Samples from various geographically distinct populations from Bulgaria and the Balearic Islands were studied by GC–MS. The alkaloid pattern of the plants of L. aestivum (subsp. pulchellum) from the Balearic Islands were dominated by crinine type compou ...
DOI:
10.1016/j.bse.2012.10.002

6. Development and validation of a GC–MS method for rapid determination of galanthamine in Leucojum aestivum and Narcissus ssp.: A metabolomic approach

Author:
Strahil Berkov; Jaume Bastida; Francesc Viladomat; Carles Codina
Source:
Talanta 2011 v.83 no.5 pp. 1455-1465
ISSN:
0039-9140
Subject:
Alzheimer disease; Leucojum aestivum; Narcissus; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; high performance liquid chromatography; leaves; metabolomics; methanol; nuclear magnetic resonance spectroscopy; pharmaceutical industry; principal component analysis; quality control; rapid methods; raw materials
Abstract:
... Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt for the treatment of Alzheimer's disease, is obtained from some Amaryllidaceae plants. A new method was developed and validated for its quantification by GC–MS in different plant sources: bulbs and leaves from Narcissus confusus; bulbs from N. pseudonarcissus cv. Carlton; and leaves and in vitro cultures from L. aestiv ...
DOI:
10.1016/j.talanta.2010.11.029

7. Hairy root and tissue cultures of Leucojum aestivum L.--relationships to galanthamine content

Author:
Diop, M. F.; Hehn, A.; Ptak, A.; Chrétien, F.; Doerper, S.; Gontier, E.; Bourgaud, F.; Henry, M.; Chapleur, Y.; Laurain-Mattar, D.
Source:
Phytochemistry reviews 2007 v.6 no.1 pp. 137-141
ISSN:
1568-7767
Subject:
Alzheimer disease; Leucojum aestivum; Rhizobium rhizogenes; acetylcholinesterase; alkaloids; cell differentiation; growth regulators; metabolites; morphogenesis; roots; tissue culture
Abstract:
... Galanthamine, an isoquinoline alkaloid acetylcholinesterase inhibitor, is an important agent used all around the world for the symptomatic treatment of senile dementia of the Alzheimer's type. The production of this metabolite and the availability of the plant are limited and prompted the search for an alternative way to obtain this valuable metabolite using in vitro cultures of Leucojum aestivum ...
DOI:
10.1007/s11101-006-9043-z